SIMILAR PATTERNS OF AMINO ACIDS FOR 5KB6_B_ADNB401_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aor ALDEHYDE FERREDOXIN
OXIDOREDUCTASE


(Pyrococcus
furiosus)
PF01314
(AFOR_C)
PF02730
(AFOR_N)
5 GLY A 190
ILE A  61
ALA A 184
GLY A 185
ALA A  92
None
None
None
PTE  A 609 (-3.7A)
PTE  A 609 (-3.0A)
0.87A 5kb6B-1aorA:
undetectable
5kb6B-1aorA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b3n PROTEIN (KETOACYL
ACYL CARRIER PROTEIN
SYNTHASE 2)


(Escherichia
coli)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
5 GLY A 171
ILE A 177
ALA A 187
GLY A 188
ALA A 103
None
0.87A 5kb6B-1b3nA:
undetectable
5kb6B-1b3nA:
23.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1dgm ADENOSINE KINASE

(Toxoplasma
gondii)
PF00294
(PfkB)
8 THR A 278
GLY A 280
VAL A 302
ILE A 310
ALA A 316
GLY A 317
ALA A 345
ILE A 349
None
None
None
None
ACY  A 370 (-4.0A)
ACY  A 370 (-3.5A)
None
None
0.59A 5kb6B-1dgmA:
47.4
5kb6B-1dgmA:
32.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dih DIHYDRODIPICOLINATE
REDUCTASE


(Escherichia
coli)
PF01113
(DapB_N)
PF05173
(DapB_C)
5 VAL A  31
ILE A  10
ALA A 247
GLY A 246
ILE A  77
None
0.82A 5kb6B-1dihA:
5.2
5kb6B-1dihA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ofu CELL DIVISION
PROTEIN FTSZ


(Pseudomonas
aeruginosa)
PF00091
(Tubulin)
PF12327
(FtsZ_C)
6 GLY A  20
ILE A  17
ALA A 113
GLY A 112
ALA A 114
ILE A 117
GDP  A1318 (-3.5A)
None
None
None
None
None
1.32A 5kb6B-1ofuA:
7.7
5kb6B-1ofuA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ojg SENSOR PROTEIN DCUS

(Escherichia
coli)
PF17203
(sCache_3_2)
5 THR A 150
ILE A  82
ALA A  60
ALA A  64
ILE A  85
None
0.86A 5kb6B-1ojgA:
undetectable
5kb6B-1ojgA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p74 SHIKIMATE
5-DEHYDROGENASE


(Haemophilus
influenzae)
PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N)
6 GLY A 133
ILE A 145
ALA A 127
GLY A 128
ALA A 187
ILE A 124
None
1.13A 5kb6B-1p74A:
undetectable
5kb6B-1p74A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pl8 HUMAN SORBITOL
DEHYDROGENASE


(Homo sapiens)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
6 THR A 246
ILE A 223
ALA A 258
GLY A 259
ALA A 232
ILE A 231
None
NAD  A 400 ( 4.0A)
None
None
None
None
1.22A 5kb6B-1pl8A:
4.5
5kb6B-1pl8A:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pl8 HUMAN SORBITOL
DEHYDROGENASE


(Homo sapiens)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
6 THR A 246
VAL A 200
ILE A 223
ALA A 258
GLY A 259
ILE A 231
None
None
NAD  A 400 ( 4.0A)
None
None
None
1.19A 5kb6B-1pl8A:
4.5
5kb6B-1pl8A:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qhb HALOPEROXIDASE

(Corallina
officinalis)
PF01569
(PAP2)
6 ARG A  29
VAL A 142
ILE A 570
ALA A 491
GLY A 490
ALA A 390
None
1.37A 5kb6B-1qhbA:
undetectable
5kb6B-1qhbA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rk2 RIBOKINASE

(Escherichia
coli)
PF00294
(PfkB)
6 THR A 223
GLY A 225
ALA A 253
GLY A 254
HIS A 279
ALA A 282
ADP  A 310 (-3.4A)
ADP  A 310 (-3.7A)
ADP  A 310 (-3.5A)
ADP  A 310 (-3.3A)
ADP  A 310 (-3.6A)
ADP  A 310 (-3.3A)
0.35A 5kb6B-1rk2A:
30.9
5kb6B-1rk2A:
28.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t5o TRANSLATION
INITIATION FACTOR
EIF2B, SUBUNIT DELTA


(Archaeoglobus
fulgidus)
PF01008
(IF-2B)
5 GLY A  46
GLN A  17
ALA A  52
ALA A  53
ILE A   6
None
0.82A 5kb6B-1t5oA:
3.3
5kb6B-1t5oA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1td2 PYRIDOXAMINE KINASE

(Escherichia
coli)
PF08543
(Phos_pyr_kin)
5 GLY A 223
ILE A 254
ALA A  21
GLY A  18
ALA A  22
None
None
None
PXL  A 288 ( 4.1A)
None
0.84A 5kb6B-1td2A:
18.2
5kb6B-1td2A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1to5 SUPEROXIDE DISMUTASE

(Schistosoma
mansoni)
PF00080
(Sod_Cu)
5 GLY A  36
ILE A 118
ALA A  88
GLY A  89
ALA A  94
None
0.92A 5kb6B-1to5A:
undetectable
5kb6B-1to5A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u7w COENZYME A
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
COABC


(Escherichia
coli)
PF04127
(DFP)
5 ILE A 270
ALA A 229
GLY A 228
ALA A 224
ILE A 191
None
0.90A 5kb6B-1u7wA:
3.4
5kb6B-1u7wA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v5f PYRUVATE OXIDASE

(Aerococcus
viridans)
PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
5 GLY A 222
ALA A 214
GLY A 215
ALA A 278
ILE A 212
None
None
FAD  A1601 (-2.9A)
None
None
0.92A 5kb6B-1v5fA:
undetectable
5kb6B-1v5fA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vic 3-DEOXY-MANNO-OCTULO
SONATE
CYTIDYLYLTRANSFERASE


(Haemophilus
influenzae)
PF02348
(CTP_transf_3)
5 ILE A   7
ALA A  63
GLY A  62
ALA A  58
ILE A  47
None
0.86A 5kb6B-1vicA:
undetectable
5kb6B-1vicA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vl8 GLUCONATE
5-DEHYDROGENASE


(Thermotoga
maritima)
PF13561
(adh_short_C2)
5 GLY A  24
ILE A 188
ALA A  94
GLY A  16
ILE A 144
None
None
NAP  A 274 (-4.5A)
NAP  A 274 (-3.2A)
NAP  A 274 (-4.4A)
0.87A 5kb6B-1vl8A:
6.1
5kb6B-1vl8A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ysj PROTEIN YXEP

(Bacillus
subtilis)
PF01546
(Peptidase_M20)
PF07687
(M20_dimer)
6 ARG A 269
ILE A 184
ALA A 276
GLY A 278
ALA A 281
ILE A 186
None
1.45A 5kb6B-1ysjA:
undetectable
5kb6B-1ysjA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zcz BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH


(Thermotoga
maritima)
PF01808
(AICARFT_IMPCHas)
PF02142
(MGS)
5 GLY A  97
VAL A  85
ALA A 103
ALA A 104
ILE A  73
None
0.94A 5kb6B-1zczA:
undetectable
5kb6B-1zczA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2alb PROTEIN
DISULFIDE-ISOMERASE
A3


(Homo sapiens)
PF00085
(Thioredoxin)
6 THR A  18
GLY A  22
VAL A  54
GLN A 107
GLY A  85
ILE A  81
None
1.18A 5kb6B-2albA:
undetectable
5kb6B-2albA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bb0 IMIDAZOLONEPROPIONAS
E


(Bacillus
subtilis)
PF01979
(Amidohydro_1)
5 GLY A 257
ALA A 262
GLY A 263
ALA A 270
ILE A 248
None
0.89A 5kb6B-2bb0A:
undetectable
5kb6B-2bb0A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c49 SUGAR KINASE MJ0406

(Methanocaldococcus
jannaschii)
PF00294
(PfkB)
5 THR A 214
GLY A 216
ALA A 245
GLY A 246
ALA A 274
ANP  A1304 (-3.4A)
ANP  A1304 (-3.4A)
ANP  A1304 (-3.5A)
ANP  A1304 (-3.2A)
ANP  A1304 (-3.1A)
0.38A 5kb6B-2c49A:
27.4
5kb6B-2c49A:
27.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d2e SUFC PROTEIN

(Thermus
thermophilus)
PF00005
(ABC_tran)
5 GLY A  46
VAL A 166
ILE A   6
GLY A  51
ILE A  62
None
None
None
GOL  A 801 (-3.8A)
None
0.91A 5kb6B-2d2eA:
undetectable
5kb6B-2d2eA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e3j EPOXIDE HYDROLASE
EPHB


(Mycobacterium
tuberculosis)
PF00561
(Abhydrolase_1)
5 GLY A 138
VAL A 129
GLN A 165
ILE A 275
GLY A 133
None
None
None
ACT  A2004 ( 4.2A)
None
0.92A 5kb6B-2e3jA:
3.8
5kb6B-2e3jA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hi1 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE 2


(Salmonella
enterica)
PF04166
(PdxA)
5 THR A 193
VAL A 198
ALA A 288
GLY A 289
ILE A 286
None
0.91A 5kb6B-2hi1A:
undetectable
5kb6B-2hi1A:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i14 NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE


(Pyrococcus
furiosus)
PF01729
(QRPTase_C)
PF02749
(QRPTase_N)
5 GLY A  58
ILE A 374
ALA A 150
ALA A 116
ILE A 153
None
0.92A 5kb6B-2i14A:
undetectable
5kb6B-2i14A:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i5b PHOSPHOMETHYLPYRIMID
INE KINASE


(Bacillus
subtilis)
PF08543
(Phos_pyr_kin)
5 THR A 178
GLY A 180
ALA A 214
GLY A 215
ILE A 247
ADP  A 301 (-3.5A)
ADP  A 301 (-3.5A)
ADP  A 301 (-3.6A)
ADP  A 301 (-3.2A)
ADP  A 301 (-4.3A)
0.80A 5kb6B-2i5bA:
19.0
5kb6B-2i5bA:
24.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2i6b ADENOSINE KINASE

(Homo sapiens)
PF00294
(PfkB)
8 THR A 265
GLY A 267
VAL A 284
ILE A 293
ALA A 298
GLY A 299
HIS A 324
ALA A 327
None
0.84A 5kb6B-2i6bA:
52.1
5kb6B-2i6bA:
86.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2is8 MOLYBDOPTERIN
BIOSYNTHESIS ENZYME,
MOAB


(Thermus
thermophilus)
PF00994
(MoCF_biosynth)
6 GLY A  70
ASP A  20
ILE A   6
ALA A 135
GLY A 134
ILE A  26
None
FMT  A1003 (-3.7A)
None
None
None
None
1.29A 5kb6B-2is8A:
undetectable
5kb6B-2is8A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iwz 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE


(Homo sapiens)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
6 GLY A 217
ILE A 223
ALA A 233
GLY A 234
HIS A 203
ALA A 149
None
1.09A 5kb6B-2iwzA:
undetectable
5kb6B-2iwzA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mt4 TRANSCRIPTION
TERMINATION/ANTITERM
INATION PROTEIN NUSA


(Bacillus
subtilis)
PF08529
(NusA_N)
5 GLY A  54
ILE A  27
ALA A 106
GLY A 103
ALA A 107
None
0.93A 5kb6B-2mt4A:
undetectable
5kb6B-2mt4A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r6r CELL DIVISION
PROTEIN FTSZ


(Aquifex
aeolicus)
PF00091
(Tubulin)
PF12327
(FtsZ_C)
6 GLY 1  16
ILE 1  13
ALA 1 109
GLY 1 108
ALA 1 110
ILE 1 113
GDP  1 339 (-3.5A)
None
None
None
None
None
1.32A 5kb6B-2r6r1:
7.6
5kb6B-2r6r1:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r9v ATP SYNTHASE SUBUNIT
ALPHA


(Thermotoga
maritima)
PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N)
6 GLY A 113
ILE A  96
ALA A 242
GLY A 243
ALA A 245
ILE A 130
None
1.16A 5kb6B-2r9vA:
undetectable
5kb6B-2r9vA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rbc SUGAR KINASE

(Agrobacterium
fabrum)
PF00294
(PfkB)
6 THR A 220
GLY A 222
GLN A 243
ALA A 252
GLY A 253
ALA A 281
EDO  A 331 (-3.9A)
EDO  A 331 (-3.1A)
None
None
None
EDO  A 331 ( 3.7A)
1.01A 5kb6B-2rbcA:
29.7
5kb6B-2rbcA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vaw CELL DIVISION
PROTEIN FTSZ


(Pseudomonas
aeruginosa)
PF00091
(Tubulin)
PF12327
(FtsZ_C)
6 GLY A  20
ILE A  17
ALA A 113
GLY A 112
ALA A 114
ILE A 117
GDP  A1317 (-3.4A)
None
None
None
None
None
1.46A 5kb6B-2vawA:
7.4
5kb6B-2vawA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y6g XYLANASE

(Rhodothermus
marinus)
PF02018
(CBM_4_9)
5 GLY A 154
ALA A  99
GLY A  98
ALA A  94
ILE A 157
None
0.92A 5kb6B-2y6gA:
undetectable
5kb6B-2y6gA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3anw PUTATIVE
UNCHARACTERIZED
PROTEIN


(Thermococcus
kodakarensis)
no annotation 5 GLY A 157
ILE A 171
GLY A  85
ALA A 165
ILE A 167
None
0.89A 5kb6B-3anwA:
undetectable
5kb6B-3anwA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bf5 RIBOKINASE RELATED
PROTEIN


(Thermoplasma
acidophilum)
PF00294
(PfkB)
5 GLY A 198
ALA A 225
GLY A 226
ALA A 254
ILE A 258
PGO  A 290 (-3.8A)
PGO  A 290 ( 4.1A)
PGO  A 290 ( 4.6A)
PGO  A 290 ( 3.8A)
None
0.54A 5kb6B-3bf5A:
22.6
5kb6B-3bf5A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bf5 RIBOKINASE RELATED
PROTEIN


(Thermoplasma
acidophilum)
PF00294
(PfkB)
5 THR A 196
GLY A 198
ALA A 225
GLY A 226
ALA A 254
PGO  A 290 (-4.0A)
PGO  A 290 (-3.8A)
PGO  A 290 ( 4.1A)
PGO  A 290 ( 4.6A)
PGO  A 290 ( 3.8A)
0.50A 5kb6B-3bf5A:
22.6
5kb6B-3bf5A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cnj CHOLESTEROL OXIDASE

(Streptomyces
sp. SA-COO)
PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C)
5 GLY A 114
ILE A 244
ALA A  22
GLY A  21
ALA A  23
FAD  A 510 (-3.0A)
None
None
FAD  A 510 (-4.2A)
None
0.93A 5kb6B-3cnjA:
2.4
5kb6B-3cnjA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ewm UNCHARACTERIZED
SUGAR KINASE PH1459


(Pyrococcus
horikoshii)
PF00294
(PfkB)
5 THR A 215
GLY A 217
ALA A 245
GLY A 246
ALA A 276
None
0.57A 5kb6B-3ewmA:
28.4
5kb6B-3ewmA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ffs INOSINE-5-MONOPHOSPH
ATE DEHYDROGENASE


(Cryptosporidium
parvum)
PF00478
(IMPDH)
5 GLY A 262
ILE A 232
ALA A 269
ALA A 251
ILE A 235
None
0.83A 5kb6B-3ffsA:
undetectable
5kb6B-3ffsA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fy5 SEGMENT POLARITY
PROTEIN DISHEVELLED
HOMOLOG DVL-2


(Xenopus laevis)
PF00595
(PDZ)
5 GLY A 296
VAL A 255
ILE A 283
GLY A 290
ILE A 267
None
0.94A 5kb6B-3fy5A:
undetectable
5kb6B-3fy5A:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hea ARYLESTERASE

(Pseudomonas
fluorescens)
PF00561
(Abhydrolase_1)
5 ILE A 210
ALA A 234
GLY A 231
ALA A 235
ILE A 238
None
0.88A 5kb6B-3heaA:
4.4
5kb6B-3heaA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hee RIBOSE-5-PHOSPHATE
ISOMERASE


(Ruminiclostridium
thermocellum)
PF02502
(LacAB_rpiB)
5 GLY A  61
ARG A  60
GLY A  46
ALA A  75
ILE A  81
None
0.92A 5kb6B-3heeA:
undetectable
5kb6B-3heeA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hs3 RIBOSE OPERON
REPRESSOR


(Lactobacillus
acidophilus)
PF13377
(Peripla_BP_3)
6 GLY A  80
VAL A  84
ILE A  64
HIS A 291
ALA A 289
ILE A 121
None
1.12A 5kb6B-3hs3A:
3.3
5kb6B-3hs3A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i3y CARBOHYDRATE KINASE

(Klebsiella
pneumoniae)
PF00294
(PfkB)
5 THR A 200
GLY A 202
ALA A 230
GLY A 231
ALA A 261
None
0.57A 5kb6B-3i3yA:
25.9
5kb6B-3i3yA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iqd OCTOPINE
DEHYDROGENASE


(Pecten maximus)
PF02317
(Octopine_DH)
5 GLY B 397
ILE B 171
ALA B 133
GLY B 130
ALA B 134
None
0.94A 5kb6B-3iqdB:
3.4
5kb6B-3iqdB:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kd6 CARBOHYDRATE KINASE,
PFKB FAMILY


(Chlorobaculum
tepidum)
PF00294
(PfkB)
5 GLY A 206
ILE A 229
ALA A 235
GLY A 236
ALA A 269
None
None
None
GOL  A 501 ( 3.2A)
None
0.62A 5kb6B-3kd6A:
26.3
5kb6B-3kd6A:
25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lhx KETODEOXYGLUCONOKINA
SE


(Shigella
flexneri)
PF00294
(PfkB)
6 GLY A 303
ALA A 335
GLY A 336
HIS A 361
ALA A 364
ILE A 368
None
0.47A 5kb6B-3lhxA:
31.6
5kb6B-3lhxA:
23.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3loo ANOPHELES GAMBIAE
ADENOSINE KINASE


(Anopheles
gambiae)
PF00294
(PfkB)
7 THR A 263
GLY A 265
VAL A 284
ALA A 298
GLY A 299
ALA A 327
ILE A 331
B4P  A 349 (-3.5A)
B4P  A 349 (-3.6A)
None
B4P  A 349 (-3.3A)
B4P  A 349 (-3.3A)
B4P  A 349 (-3.4A)
None
0.45A 5kb6B-3looA:
46.4
5kb6B-3looA:
48.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lws AROMATIC AMINO ACID
BETA-ELIMINATING
LYASE/THREONINE
ALDOLASE


(Exiguobacterium
sibiricum)
PF01212
(Beta_elim_lyase)
6 GLY A  60
ILE A 201
ALA A 216
GLY A 217
ALA A  64
ILE A 214
None
1.42A 5kb6B-3lwsA:
undetectable
5kb6B-3lwsA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1a PUTATIVE
DEHYDROGENASE


(Streptomyces
avermitilis)
PF00106
(adh_short)
5 GLY A  18
VAL A  10
ILE A 232
ALA A  24
ALA A  25
None
0.87A 5kb6B-3m1aA:
5.5
5kb6B-3m1aA:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m8y PHOSPHOPENTOMUTASE

(Bacillus cereus)
PF01676
(Metalloenzyme)
5 GLY A 329
ASP A  32
ILE A  34
GLY A 290
HIS A 334
None
GOL  A 400 ( 4.4A)
None
None
MN  A 397 (-3.4A)
0.93A 5kb6B-3m8yA:
undetectable
5kb6B-3m8yA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mnd SUPEROXIDE DISMUTASE
[CU-ZN]


(Taenia solium)
PF00080
(Sod_Cu)
5 GLY A  34
ILE A 116
ALA A  86
GLY A  87
ALA A  92
None
0.91A 5kb6B-3mndA:
undetectable
5kb6B-3mndA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oq0 DBF4

(Saccharomyces
cerevisiae)
PF08630
(Dfp1_Him1_M)
5 GLY A 154
ILE A 174
ALA A 160
GLY A 159
ILE A 126
None
0.87A 5kb6B-3oq0A:
undetectable
5kb6B-3oq0A:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oq4 DBF4

(Saccharomyces
cerevisiae)
PF08630
(Dfp1_Him1_M)
5 GLY A 154
ILE A 174
ALA A 160
GLY A 159
ILE A 126
None
0.87A 5kb6B-3oq4A:
undetectable
5kb6B-3oq4A:
16.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3otx ADENOSINE KINASE,
PUTATIVE


(Trypanosoma
brucei)
PF00294
(PfkB)
8 THR A 264
VAL A 283
GLN A 288
ALA A 297
GLY A 298
HIS A 323
ALA A 326
ILE A 330
AP5  A 346 (-3.6A)
AP5  A 346 (-4.1A)
AP5  A 346 (-3.1A)
AP5  A 346 (-3.4A)
AP5  A 346 (-3.2A)
AP5  A 346 (-3.8A)
AP5  A 346 (-3.0A)
AP5  A 346 (-4.9A)
0.54A 5kb6B-3otxA:
44.8
5kb6B-3otxA:
40.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ph3 RIBOSE-5-PHOSPHATE
ISOMERASE


(Ruminiclostridium
thermocellum)
PF02502
(LacAB_rpiB)
5 GLY A  61
ARG A  60
GLY A  46
ALA A  75
ILE A  81
None
0.91A 5kb6B-3ph3A:
undetectable
5kb6B-3ph3A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qe3 SORBITOL
DEHYDROGENASE


(Ovis aries)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
6 THR A 245
ILE A 222
ALA A 257
GLY A 258
ALA A 231
ILE A 230
None
1.14A 5kb6B-3qe3A:
4.1
5kb6B-3qe3A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qe3 SORBITOL
DEHYDROGENASE


(Ovis aries)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
6 THR A 245
VAL A 199
ILE A 222
ALA A 257
GLY A 258
ILE A 230
None
1.15A 5kb6B-3qe3A:
4.1
5kb6B-3qe3A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r0v ALPHA/BETA HYDROLASE
FOLD PROTEIN


(Sphaerobacter
thermophilus)
PF12697
(Abhydrolase_6)
5 GLY A  96
ILE A 229
ALA A 102
ALA A 103
ILE A 202
None
0.91A 5kb6B-3r0vA:
4.5
5kb6B-3r0vA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqd 3-DEOXY-MANNO-OCTULO
SONATE
CYTIDYLYLTRANSFERASE


(Coxiella
burnetii)
PF02348
(CTP_transf_3)
5 ILE A   7
ALA A  63
GLY A  62
ALA A  58
ILE A  47
None
0.84A 5kb6B-3tqdA:
undetectable
5kb6B-3tqdA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ubo ADENOSINE KINASE

(Sinorhizobium
meliloti)
PF00294
(PfkB)
5 THR A 245
ALA A 276
GLY A 277
ALA A 305
ILE A 309
ADP  A 354 (-3.3A)
ADP  A 354 (-3.4A)
ADP  A 354 (-3.4A)
ADP  A 354 (-2.7A)
None
0.58A 5kb6B-3uboA:
35.7
5kb6B-3uboA:
26.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vas PUTATIVE ADENOSINE
KINASE


(Schistosoma
mansoni)
PF00294
(PfkB)
7 THR A 265
GLY A 267
ILE A 294
ALA A 300
GLY A 301
ALA A 329
ILE A 333
None
0.61A 5kb6B-3vasA:
45.4
5kb6B-3vasA:
37.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vas PUTATIVE ADENOSINE
KINASE


(Schistosoma
mansoni)
PF00294
(PfkB)
7 THR A 265
GLY A 267
VAL A 286
ALA A 300
GLY A 301
ALA A 329
ILE A 333
None
0.40A 5kb6B-3vasA:
45.4
5kb6B-3vasA:
37.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e3a SUGAR KINASE PROTEIN

(Rhizobium etli)
PF00294
(PfkB)
6 THR A 243
ILE A 265
ALA A 274
GLY A 275
ALA A 303
ILE A 307
None
1.33A 5kb6B-4e3aA:
36.8
5kb6B-4e3aA:
27.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e69 2-DEHYDRO-3-DEOXYGLU
CONOKINASE


(Oceanicola
granulosus)
PF00294
(PfkB)
5 GLY A 225
VAL A 242
ALA A 254
GLY A 255
ALA A 283
None
0.35A 5kb6B-4e69A:
31.9
5kb6B-4e69A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f32 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2


(Burkholderia
vietnamiensis)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
5 GLY A 242
ALA A 353
GLY A 352
ALA A 354
ILE A 357
None
None
CSU  A 172 ( 4.7A)
CSU  A 172 ( 4.7A)
None
0.93A 5kb6B-4f32A:
undetectable
5kb6B-4f32A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fr2 1,3-PROPANEDIOL
DEHYDROGENASE


(Oenococcus oeni)
PF00465
(Fe-ADH)
5 GLY A 145
ILE A 227
ALA A 254
GLY A 255
HIS A 267
None
None
None
None
NI  A 501 (-3.4A)
0.90A 5kb6B-4fr2A:
2.5
5kb6B-4fr2A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g1j SORTASE FAMILY
PROTEIN


(Streptococcus
agalactiae)
PF04203
(Sortase)
5 GLY A 181
ASP A 252
GLN A 258
GLY A 239
ILE A 242
None
0.85A 5kb6B-4g1jA:
undetectable
5kb6B-4g1jA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4is2 BILE ACID 3-ALPHA
HYDROXYSTEROID
DEHYDROGENASE


([Clostridium]
scindens)
PF00106
(adh_short)
5 GLY A  17
ARG A  16
ALA A  22
ALA A  23
ILE A  11
None
0.91A 5kb6B-4is2A:
5.9
5kb6B-4is2A:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jhy HYPOTHETICAL PROTEIN

(Parabacteroides
distasonis)
PF14730
(DUF4468)
5 THR A  47
ILE A 106
ALA A 178
ALA A  55
ILE A  56
None
0.87A 5kb6B-4jhyA:
undetectable
5kb6B-4jhyA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jrm 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2


(Vibrio cholerae)
no annotation 5 GLY D 172
ILE D 178
ALA D 188
GLY D 189
ALA D 104
None
0.86A 5kb6B-4jrmD:
undetectable
5kb6B-4jrmD:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpg MEMBRANE-ANCHORED
MYCOSIN MYCP1


(Mycolicibacterium
smegmatis)
PF00082
(Peptidase_S8)
5 GLY A 195
ALA A 231
GLY A 230
ALA A 225
ILE A 199
None
0.91A 5kb6B-4kpgA:
3.8
5kb6B-4kpgA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kys THIAMINE
PYRIDINYLASE I


(Clostridium
botulinum)
PF01547
(SBP_bac_1)
5 ILE A 267
ALA A 237
GLY A 238
ALA A 242
ILE A 187
None
0.88A 5kb6B-4kysA:
undetectable
5kb6B-4kysA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lb0 UNCHARACTERIZED
PROTEIN


(Agrobacterium
vitis)
PF05544
(Pro_racemase)
5 THR A 257
GLY A 173
VAL A 147
ALA A  91
ILE A 222
ACT  A 401 (-2.8A)
None
None
None
None
0.85A 5kb6B-4lb0A:
undetectable
5kb6B-4lb0A:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lmp ALANINE
DEHYDROGENASE


(Mycobacterium
tuberculosis)
PF01262
(AlaDh_PNT_C)
PF05222
(AlaDh_PNT_N)
5 GLY A  22
ILE A   5
ALA A  55
GLY A  54
ILE A  35
None
0.77A 5kb6B-4lmpA:
5.2
5kb6B-4lmpA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ls5 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2


(Bacillus
subtilis)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
5 GLY A 231
ALA A 343
GLY A 342
ALA A 344
ILE A 347
None
0.84A 5kb6B-4ls5A:
undetectable
5kb6B-4ls5A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m1z MEMBRANE-ANCHORED
MYCOSIN MYCP1


(Mycolicibacterium
smegmatis)
PF00082
(Peptidase_S8)
5 GLY A 195
ALA A 231
GLY A 230
ALA A 225
ILE A 199
None
0.92A 5kb6B-4m1zA:
3.7
5kb6B-4m1zA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4my0 GCN5-RELATED
N-ACETYLTRANSFERASE


(Kribbella
flavida)
PF13527
(Acetyltransf_9)
PF13530
(SCP2_2)
6 THR A 352
GLY A 134
GLN A  70
ILE A 115
ALA A 346
GLY A 344
None
1.46A 5kb6B-4my0A:
undetectable
5kb6B-4my0A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mzy NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE


(Enterococcus
faecalis)
PF04095
(NAPRTase)
5 GLY A  55
ILE A 436
ALA A 177
ALA A 142
ILE A 180
None
GOL  A 504 ( 4.3A)
None
None
None
0.82A 5kb6B-4mzyA:
undetectable
5kb6B-4mzyA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ns4 ALPHA/BETA HYDROLASE
FOLD PROTEIN


(Psychrobacter
cryohalolentis)
PF00561
(Abhydrolase_1)
5 VAL A 216
ILE A 253
ALA A 126
ALA A 127
ILE A 223
None
0.94A 5kb6B-4ns4A:
undetectable
5kb6B-4ns4A:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4olq ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN


(Hyphomonas
neptunium)
PF00378
(ECH_1)
5 GLY A 113
ILE A  35
ALA A 119
ALA A 120
ILE A  94
None
0.91A 5kb6B-4olqA:
undetectable
5kb6B-4olqA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pvv ADENOSINE KINASE

(Mycobacterium
tuberculosis)
PF00294
(PfkB)
5 THR A 223
GLY A 225
VAL A 243
GLY A 256
ALA A 284
None
0.69A 5kb6B-4pvvA:
26.3
5kb6B-4pvvA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q2h PROLINE RACEMASE
PROTEIN


(Agrobacterium
tumefaciens)
PF05544
(Pro_racemase)
5 THR A 257
GLY A 173
VAL A 147
ALA A  91
ILE A 222
BCT  A 401 (-2.8A)
None
None
None
None
0.88A 5kb6B-4q2hA:
undetectable
5kb6B-4q2hA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r8e 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2


(Yersinia pestis)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
5 GLY A 171
ILE A 177
ALA A 187
GLY A 188
ALA A 103
None
0.91A 5kb6B-4r8eA:
undetectable
5kb6B-4r8eA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rk6 GLUCOSE-RESISTANCE
AMYLASE REGULATOR


(Weissella
paramesenteroides)
PF13377
(Peripla_BP_3)
5 GLY A 225
VAL A 229
ALA A 245
ALA A 243
ILE A 271
None
0.83A 5kb6B-4rk6A:
5.0
5kb6B-4rk6A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wjm RIBOKINASE:CARBOHYDR
ATE KINASE, PFKB


(Brucella
abortus)
PF00294
(PfkB)
5 THR A 217
GLY A 219
ALA A 247
GLY A 248
ALA A 289
ANP  A 401 (-3.5A)
ANP  A 401 (-3.6A)
ANP  A 401 (-3.3A)
ANP  A 401 (-3.4A)
ANP  A 401 (-3.5A)
0.27A 5kb6B-4wjmA:
28.9
5kb6B-4wjmA:
25.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x8f RIBOKINASE

(Vibrio cholerae)
PF00294
(PfkB)
6 THR A 220
GLY A 222
ALA A 250
GLY A 251
HIS A 276
ALA A 279
None
0.63A 5kb6B-4x8fA:
29.2
5kb6B-4x8fA:
25.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yji ARYL ACYLAMIDASE

(bacterium
CSBL00001)
PF01425
(Amidase)
7 THR A 142
GLY A 162
ILE A 188
ALA A 167
GLY A 166
ALA A 168
ILE A 227
None
1.30A 5kb6B-4yjiA:
undetectable
5kb6B-4yjiA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c41 RIBOKINASE

(Homo sapiens)
PF00294
(PfkB)
5 THR A 235
GLY A 237
ALA A 267
GLY A 268
ALA A 298
ACP  A 401 (-3.2A)
ACP  A 401 (-3.3A)
ACP  A 401 (-3.5A)
ACP  A 401 (-3.4A)
ACP  A 401 (-3.3A)
0.33A 5kb6B-5c41A:
31.5
5kb6B-5c41A:
28.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ema SORTING NEXIN-27

(Rattus
norvegicus)
PF00595
(PDZ)
5 GLY A  52
ALA A  89
GLY A  88
ALA A  90
ILE A  46
None
0.94A 5kb6B-5emaA:
undetectable
5kb6B-5emaA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5koj NITROGENASE PROTEIN
ALPHA CHAIN


(Gluconacetobacter
diazotrophicus)
PF00148
(Oxidored_nitro)
5 GLY A 407
ARG A 377
ALA A  40
GLY A  41
ILE A 416
None
0.91A 5kb6B-5kojA:
2.5
5kb6B-5kojA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m5j THIOREDOXIN
REDUCTASE


(Giardia
intestinalis)
PF07992
(Pyr_redox_2)
5 THR A  32
GLY A  10
ALA A  21
GLY A  22
ALA A 303
None
0.79A 5kb6B-5m5jA:
undetectable
5kb6B-5m5jA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xbf HARMONIN

(Homo sapiens)
PF00595
(PDZ)
5 ILE B 533
ALA B 489
GLY B 488
ALA B 490
ILE B 458
None
0.85A 5kb6B-5xbfB:
undetectable
5kb6B-5xbfB:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y9p -

(-)
no annotation 6 GLN A 180
ILE A 169
ALA A 156
GLY A 133
ALA A  93
ILE A  77
None
1.47A 5kb6B-5y9pA:
undetectable
5kb6B-5y9pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ci7 YCAO

(Methanopyrus
kandleri)
no annotation 5 GLY A 256
VAL A  43
ASP A  41
ALA A  63
ILE A  50
None
0.94A 5kb6B-6ci7A:
undetectable
5kb6B-6ci7A:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6h7x -

(-)
no annotation 5 GLY A  89
VAL A 295
ILE A  75
ALA A  56
GLY A  57
EDO  A1008 ( 4.2A)
None
None
None
None
0.90A 5kb6B-6h7xA:
undetectable
5kb6B-6h7xA:
undetectable