SIMILAR PATTERNS OF AMINO ACIDS FOR 5KB6_B_ADNB401_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1aor | ALDEHYDE FERREDOXINOXIDOREDUCTASE (Pyrococcusfuriosus) |
PF01314(AFOR_C)PF02730(AFOR_N) | 5 | GLY A 190ILE A 61ALA A 184GLY A 185ALA A 92 | NoneNoneNonePTE A 609 (-3.7A)PTE A 609 (-3.0A) | 0.87A | 5kb6B-1aorA:undetectable | 5kb6B-1aorA:22.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1b3n | PROTEIN (KETOACYLACYL CARRIER PROTEINSYNTHASE 2) (Escherichiacoli) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C) | 5 | GLY A 171ILE A 177ALA A 187GLY A 188ALA A 103 | None | 0.87A | 5kb6B-1b3nA:undetectable | 5kb6B-1b3nA:23.58 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1dgm | ADENOSINE KINASE (Toxoplasmagondii) |
PF00294(PfkB) | 8 | THR A 278GLY A 280VAL A 302ILE A 310ALA A 316GLY A 317ALA A 345ILE A 349 | NoneNoneNoneNoneACY A 370 (-4.0A)ACY A 370 (-3.5A)NoneNone | 0.59A | 5kb6B-1dgmA:47.4 | 5kb6B-1dgmA:32.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dih | DIHYDRODIPICOLINATEREDUCTASE (Escherichiacoli) |
PF01113(DapB_N)PF05173(DapB_C) | 5 | VAL A 31ILE A 10ALA A 247GLY A 246ILE A 77 | None | 0.82A | 5kb6B-1dihA:5.2 | 5kb6B-1dihA:21.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ofu | CELL DIVISIONPROTEIN FTSZ (Pseudomonasaeruginosa) |
PF00091(Tubulin)PF12327(FtsZ_C) | 6 | GLY A 20ILE A 17ALA A 113GLY A 112ALA A 114ILE A 117 | GDP A1318 (-3.5A)NoneNoneNoneNoneNone | 1.32A | 5kb6B-1ofuA:7.7 | 5kb6B-1ofuA:21.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ojg | SENSOR PROTEIN DCUS (Escherichiacoli) |
PF17203(sCache_3_2) | 5 | THR A 150ILE A 82ALA A 60ALA A 64ILE A 85 | None | 0.86A | 5kb6B-1ojgA:undetectable | 5kb6B-1ojgA:16.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1p74 | SHIKIMATE5-DEHYDROGENASE (Haemophilusinfluenzae) |
PF01488(Shikimate_DH)PF08501(Shikimate_dh_N) | 6 | GLY A 133ILE A 145ALA A 127GLY A 128ALA A 187ILE A 124 | None | 1.13A | 5kb6B-1p74A:undetectable | 5kb6B-1p74A:21.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pl8 | HUMAN SORBITOLDEHYDROGENASE (Homo sapiens) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 6 | THR A 246ILE A 223ALA A 258GLY A 259ALA A 232ILE A 231 | NoneNAD A 400 ( 4.0A)NoneNoneNoneNone | 1.22A | 5kb6B-1pl8A:4.5 | 5kb6B-1pl8A:24.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pl8 | HUMAN SORBITOLDEHYDROGENASE (Homo sapiens) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 6 | THR A 246VAL A 200ILE A 223ALA A 258GLY A 259ILE A 231 | NoneNoneNAD A 400 ( 4.0A)NoneNoneNone | 1.19A | 5kb6B-1pl8A:4.5 | 5kb6B-1pl8A:24.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qhb | HALOPEROXIDASE (Corallinaofficinalis) |
PF01569(PAP2) | 6 | ARG A 29VAL A 142ILE A 570ALA A 491GLY A 490ALA A 390 | None | 1.37A | 5kb6B-1qhbA:undetectable | 5kb6B-1qhbA:21.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rk2 | RIBOKINASE (Escherichiacoli) |
PF00294(PfkB) | 6 | THR A 223GLY A 225ALA A 253GLY A 254HIS A 279ALA A 282 | ADP A 310 (-3.4A)ADP A 310 (-3.7A)ADP A 310 (-3.5A)ADP A 310 (-3.3A)ADP A 310 (-3.6A)ADP A 310 (-3.3A) | 0.35A | 5kb6B-1rk2A:30.9 | 5kb6B-1rk2A:28.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1t5o | TRANSLATIONINITIATION FACTOREIF2B, SUBUNIT DELTA (Archaeoglobusfulgidus) |
PF01008(IF-2B) | 5 | GLY A 46GLN A 17ALA A 52ALA A 53ILE A 6 | None | 0.82A | 5kb6B-1t5oA:3.3 | 5kb6B-1t5oA:21.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1td2 | PYRIDOXAMINE KINASE (Escherichiacoli) |
PF08543(Phos_pyr_kin) | 5 | GLY A 223ILE A 254ALA A 21GLY A 18ALA A 22 | NoneNoneNonePXL A 288 ( 4.1A)None | 0.84A | 5kb6B-1td2A:18.2 | 5kb6B-1td2A:22.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1to5 | SUPEROXIDE DISMUTASE (Schistosomamansoni) |
PF00080(Sod_Cu) | 5 | GLY A 36ILE A 118ALA A 88GLY A 89ALA A 94 | None | 0.92A | 5kb6B-1to5A:undetectable | 5kb6B-1to5A:19.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1u7w | COENZYME ABIOSYNTHESISBIFUNCTIONAL PROTEINCOABC (Escherichiacoli) |
PF04127(DFP) | 5 | ILE A 270ALA A 229GLY A 228ALA A 224ILE A 191 | None | 0.90A | 5kb6B-1u7wA:3.4 | 5kb6B-1u7wA:23.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v5f | PYRUVATE OXIDASE (Aerococcusviridans) |
PF00205(TPP_enzyme_M)PF02775(TPP_enzyme_C)PF02776(TPP_enzyme_N) | 5 | GLY A 222ALA A 214GLY A 215ALA A 278ILE A 212 | NoneNoneFAD A1601 (-2.9A)NoneNone | 0.92A | 5kb6B-1v5fA:undetectable | 5kb6B-1v5fA:22.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vic | 3-DEOXY-MANNO-OCTULOSONATECYTIDYLYLTRANSFERASE (Haemophilusinfluenzae) |
PF02348(CTP_transf_3) | 5 | ILE A 7ALA A 63GLY A 62ALA A 58ILE A 47 | None | 0.86A | 5kb6B-1vicA:undetectable | 5kb6B-1vicA:21.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vl8 | GLUCONATE5-DEHYDROGENASE (Thermotogamaritima) |
PF13561(adh_short_C2) | 5 | GLY A 24ILE A 188ALA A 94GLY A 16ILE A 144 | NoneNoneNAP A 274 (-4.5A)NAP A 274 (-3.2A)NAP A 274 (-4.4A) | 0.87A | 5kb6B-1vl8A:6.1 | 5kb6B-1vl8A:21.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ysj | PROTEIN YXEP (Bacillussubtilis) |
PF01546(Peptidase_M20)PF07687(M20_dimer) | 6 | ARG A 269ILE A 184ALA A 276GLY A 278ALA A 281ILE A 186 | None | 1.45A | 5kb6B-1ysjA:undetectable | 5kb6B-1ysjA:21.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zcz | BIFUNCTIONAL PURINEBIOSYNTHESIS PROTEINPURH (Thermotogamaritima) |
PF01808(AICARFT_IMPCHas)PF02142(MGS) | 5 | GLY A 97VAL A 85ALA A 103ALA A 104ILE A 73 | None | 0.94A | 5kb6B-1zczA:undetectable | 5kb6B-1zczA:22.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2alb | PROTEINDISULFIDE-ISOMERASEA3 (Homo sapiens) |
PF00085(Thioredoxin) | 6 | THR A 18GLY A 22VAL A 54GLN A 107GLY A 85ILE A 81 | None | 1.18A | 5kb6B-2albA:undetectable | 5kb6B-2albA:14.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bb0 | IMIDAZOLONEPROPIONASE (Bacillussubtilis) |
PF01979(Amidohydro_1) | 5 | GLY A 257ALA A 262GLY A 263ALA A 270ILE A 248 | None | 0.89A | 5kb6B-2bb0A:undetectable | 5kb6B-2bb0A:22.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2c49 | SUGAR KINASE MJ0406 (Methanocaldococcusjannaschii) |
PF00294(PfkB) | 5 | THR A 214GLY A 216ALA A 245GLY A 246ALA A 274 | ANP A1304 (-3.4A)ANP A1304 (-3.4A)ANP A1304 (-3.5A)ANP A1304 (-3.2A)ANP A1304 (-3.1A) | 0.38A | 5kb6B-2c49A:27.4 | 5kb6B-2c49A:27.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2d2e | SUFC PROTEIN (Thermusthermophilus) |
PF00005(ABC_tran) | 5 | GLY A 46VAL A 166ILE A 6GLY A 51ILE A 62 | NoneNoneNoneGOL A 801 (-3.8A)None | 0.91A | 5kb6B-2d2eA:undetectable | 5kb6B-2d2eA:22.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2e3j | EPOXIDE HYDROLASEEPHB (Mycobacteriumtuberculosis) |
PF00561(Abhydrolase_1) | 5 | GLY A 138VAL A 129GLN A 165ILE A 275GLY A 133 | NoneNoneNoneACT A2004 ( 4.2A)None | 0.92A | 5kb6B-2e3jA:3.8 | 5kb6B-2e3jA:21.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hi1 | 4-HYDROXYTHREONINE-4-PHOSPHATEDEHYDROGENASE 2 (Salmonellaenterica) |
PF04166(PdxA) | 5 | THR A 193VAL A 198ALA A 288GLY A 289ILE A 286 | None | 0.91A | 5kb6B-2hi1A:undetectable | 5kb6B-2hi1A:23.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2i14 | NICOTINATE-NUCLEOTIDE PYROPHOSPHORYLASE (Pyrococcusfuriosus) |
PF01729(QRPTase_C)PF02749(QRPTase_N) | 5 | GLY A 58ILE A 374ALA A 150ALA A 116ILE A 153 | None | 0.92A | 5kb6B-2i14A:undetectable | 5kb6B-2i14A:23.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2i5b | PHOSPHOMETHYLPYRIMIDINE KINASE (Bacillussubtilis) |
PF08543(Phos_pyr_kin) | 5 | THR A 178GLY A 180ALA A 214GLY A 215ILE A 247 | ADP A 301 (-3.5A)ADP A 301 (-3.5A)ADP A 301 (-3.6A)ADP A 301 (-3.2A)ADP A 301 (-4.3A) | 0.80A | 5kb6B-2i5bA:19.0 | 5kb6B-2i5bA:24.67 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2i6b | ADENOSINE KINASE (Homo sapiens) |
PF00294(PfkB) | 8 | THR A 265GLY A 267VAL A 284ILE A 293ALA A 298GLY A 299HIS A 324ALA A 327 | None | 0.84A | 5kb6B-2i6bA:52.1 | 5kb6B-2i6bA:86.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2is8 | MOLYBDOPTERINBIOSYNTHESIS ENZYME,MOAB (Thermusthermophilus) |
PF00994(MoCF_biosynth) | 6 | GLY A 70ASP A 20ILE A 6ALA A 135GLY A 134ILE A 26 | NoneFMT A1003 (-3.7A)NoneNoneNoneNone | 1.29A | 5kb6B-2is8A:undetectable | 5kb6B-2is8A:18.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2iwz | 3-OXOACYL-[ACYL-CARRIER-PROTEIN]SYNTHASE (Homo sapiens) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C) | 6 | GLY A 217ILE A 223ALA A 233GLY A 234HIS A 203ALA A 149 | None | 1.09A | 5kb6B-2iwzA:undetectable | 5kb6B-2iwzA:23.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2mt4 | TRANSCRIPTIONTERMINATION/ANTITERMINATION PROTEIN NUSA (Bacillussubtilis) |
PF08529(NusA_N) | 5 | GLY A 54ILE A 27ALA A 106GLY A 103ALA A 107 | None | 0.93A | 5kb6B-2mt4A:undetectable | 5kb6B-2mt4A:20.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2r6r | CELL DIVISIONPROTEIN FTSZ (Aquifexaeolicus) |
PF00091(Tubulin)PF12327(FtsZ_C) | 6 | GLY 1 16ILE 1 13ALA 1 109GLY 1 108ALA 1 110ILE 1 113 | GDP 1 339 (-3.5A)NoneNoneNoneNoneNone | 1.32A | 5kb6B-2r6r1:7.6 | 5kb6B-2r6r1:23.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2r9v | ATP SYNTHASE SUBUNITALPHA (Thermotogamaritima) |
PF00006(ATP-synt_ab)PF00306(ATP-synt_ab_C)PF02874(ATP-synt_ab_N) | 6 | GLY A 113ILE A 96ALA A 242GLY A 243ALA A 245ILE A 130 | None | 1.16A | 5kb6B-2r9vA:undetectable | 5kb6B-2r9vA:21.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rbc | SUGAR KINASE (Agrobacteriumfabrum) |
PF00294(PfkB) | 6 | THR A 220GLY A 222GLN A 243ALA A 252GLY A 253ALA A 281 | EDO A 331 (-3.9A)EDO A 331 (-3.1A)NoneNoneNoneEDO A 331 ( 3.7A) | 1.01A | 5kb6B-2rbcA:29.7 | 5kb6B-2rbcA:24.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vaw | CELL DIVISIONPROTEIN FTSZ (Pseudomonasaeruginosa) |
PF00091(Tubulin)PF12327(FtsZ_C) | 6 | GLY A 20ILE A 17ALA A 113GLY A 112ALA A 114ILE A 117 | GDP A1317 (-3.4A)NoneNoneNoneNoneNone | 1.46A | 5kb6B-2vawA:7.4 | 5kb6B-2vawA:24.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2y6g | XYLANASE (Rhodothermusmarinus) |
PF02018(CBM_4_9) | 5 | GLY A 154ALA A 99GLY A 98ALA A 94ILE A 157 | None | 0.92A | 5kb6B-2y6gA:undetectable | 5kb6B-2y6gA:20.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3anw | PUTATIVEUNCHARACTERIZEDPROTEIN (Thermococcuskodakarensis) |
no annotation | 5 | GLY A 157ILE A 171GLY A 85ALA A 165ILE A 167 | None | 0.89A | 5kb6B-3anwA:undetectable | 5kb6B-3anwA:22.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bf5 | RIBOKINASE RELATEDPROTEIN (Thermoplasmaacidophilum) |
PF00294(PfkB) | 5 | GLY A 198ALA A 225GLY A 226ALA A 254ILE A 258 | PGO A 290 (-3.8A)PGO A 290 ( 4.1A)PGO A 290 ( 4.6A)PGO A 290 ( 3.8A)None | 0.54A | 5kb6B-3bf5A:22.6 | 5kb6B-3bf5A:21.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bf5 | RIBOKINASE RELATEDPROTEIN (Thermoplasmaacidophilum) |
PF00294(PfkB) | 5 | THR A 196GLY A 198ALA A 225GLY A 226ALA A 254 | PGO A 290 (-4.0A)PGO A 290 (-3.8A)PGO A 290 ( 4.1A)PGO A 290 ( 4.6A)PGO A 290 ( 3.8A) | 0.50A | 5kb6B-3bf5A:22.6 | 5kb6B-3bf5A:21.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cnj | CHOLESTEROL OXIDASE (Streptomycessp. SA-COO) |
PF00732(GMC_oxred_N)PF05199(GMC_oxred_C) | 5 | GLY A 114ILE A 244ALA A 22GLY A 21ALA A 23 | FAD A 510 (-3.0A)NoneNoneFAD A 510 (-4.2A)None | 0.93A | 5kb6B-3cnjA:2.4 | 5kb6B-3cnjA:21.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ewm | UNCHARACTERIZEDSUGAR KINASE PH1459 (Pyrococcushorikoshii) |
PF00294(PfkB) | 5 | THR A 215GLY A 217ALA A 245GLY A 246ALA A 276 | None | 0.57A | 5kb6B-3ewmA:28.4 | 5kb6B-3ewmA:22.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ffs | INOSINE-5-MONOPHOSPHATE DEHYDROGENASE (Cryptosporidiumparvum) |
PF00478(IMPDH) | 5 | GLY A 262ILE A 232ALA A 269ALA A 251ILE A 235 | None | 0.83A | 5kb6B-3ffsA:undetectable | 5kb6B-3ffsA:20.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fy5 | SEGMENT POLARITYPROTEIN DISHEVELLEDHOMOLOG DVL-2 (Xenopus laevis) |
PF00595(PDZ) | 5 | GLY A 296VAL A 255ILE A 283GLY A 290ILE A 267 | None | 0.94A | 5kb6B-3fy5A:undetectable | 5kb6B-3fy5A:13.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hea | ARYLESTERASE (Pseudomonasfluorescens) |
PF00561(Abhydrolase_1) | 5 | ILE A 210ALA A 234GLY A 231ALA A 235ILE A 238 | None | 0.88A | 5kb6B-3heaA:4.4 | 5kb6B-3heaA:22.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hee | RIBOSE-5-PHOSPHATEISOMERASE (Ruminiclostridiumthermocellum) |
PF02502(LacAB_rpiB) | 5 | GLY A 61ARG A 60GLY A 46ALA A 75ILE A 81 | None | 0.92A | 5kb6B-3heeA:undetectable | 5kb6B-3heeA:16.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hs3 | RIBOSE OPERONREPRESSOR (Lactobacillusacidophilus) |
PF13377(Peripla_BP_3) | 6 | GLY A 80VAL A 84ILE A 64HIS A 291ALA A 289ILE A 121 | None | 1.12A | 5kb6B-3hs3A:3.3 | 5kb6B-3hs3A:21.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i3y | CARBOHYDRATE KINASE (Klebsiellapneumoniae) |
PF00294(PfkB) | 5 | THR A 200GLY A 202ALA A 230GLY A 231ALA A 261 | None | 0.57A | 5kb6B-3i3yA:25.9 | 5kb6B-3i3yA:23.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3iqd | OCTOPINEDEHYDROGENASE (Pecten maximus) |
PF02317(Octopine_DH) | 5 | GLY B 397ILE B 171ALA B 133GLY B 130ALA B 134 | None | 0.94A | 5kb6B-3iqdB:3.4 | 5kb6B-3iqdB:23.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kd6 | CARBOHYDRATE KINASE,PFKB FAMILY (Chlorobaculumtepidum) |
PF00294(PfkB) | 5 | GLY A 206ILE A 229ALA A 235GLY A 236ALA A 269 | NoneNoneNoneGOL A 501 ( 3.2A)None | 0.62A | 5kb6B-3kd6A:26.3 | 5kb6B-3kd6A:25.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lhx | KETODEOXYGLUCONOKINASE (Shigellaflexneri) |
PF00294(PfkB) | 6 | GLY A 303ALA A 335GLY A 336HIS A 361ALA A 364ILE A 368 | None | 0.47A | 5kb6B-3lhxA:31.6 | 5kb6B-3lhxA:23.44 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3loo | ANOPHELES GAMBIAEADENOSINE KINASE (Anophelesgambiae) |
PF00294(PfkB) | 7 | THR A 263GLY A 265VAL A 284ALA A 298GLY A 299ALA A 327ILE A 331 | B4P A 349 (-3.5A)B4P A 349 (-3.6A)NoneB4P A 349 (-3.3A)B4P A 349 (-3.3A)B4P A 349 (-3.4A)None | 0.45A | 5kb6B-3looA:46.4 | 5kb6B-3looA:48.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lws | AROMATIC AMINO ACIDBETA-ELIMINATINGLYASE/THREONINEALDOLASE (Exiguobacteriumsibiricum) |
PF01212(Beta_elim_lyase) | 6 | GLY A 60ILE A 201ALA A 216GLY A 217ALA A 64ILE A 214 | None | 1.42A | 5kb6B-3lwsA:undetectable | 5kb6B-3lwsA:22.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3m1a | PUTATIVEDEHYDROGENASE (Streptomycesavermitilis) |
PF00106(adh_short) | 5 | GLY A 18VAL A 10ILE A 232ALA A 24ALA A 25 | None | 0.87A | 5kb6B-3m1aA:5.5 | 5kb6B-3m1aA:24.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3m8y | PHOSPHOPENTOMUTASE (Bacillus cereus) |
PF01676(Metalloenzyme) | 5 | GLY A 329ASP A 32ILE A 34GLY A 290HIS A 334 | NoneGOL A 400 ( 4.4A)NoneNone MN A 397 (-3.4A) | 0.93A | 5kb6B-3m8yA:undetectable | 5kb6B-3m8yA:22.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mnd | SUPEROXIDE DISMUTASE[CU-ZN] (Taenia solium) |
PF00080(Sod_Cu) | 5 | GLY A 34ILE A 116ALA A 86GLY A 87ALA A 92 | None | 0.91A | 5kb6B-3mndA:undetectable | 5kb6B-3mndA:20.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3oq0 | DBF4 (Saccharomycescerevisiae) |
PF08630(Dfp1_Him1_M) | 5 | GLY A 154ILE A 174ALA A 160GLY A 159ILE A 126 | None | 0.87A | 5kb6B-3oq0A:undetectable | 5kb6B-3oq0A:18.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3oq4 | DBF4 (Saccharomycescerevisiae) |
PF08630(Dfp1_Him1_M) | 5 | GLY A 154ILE A 174ALA A 160GLY A 159ILE A 126 | None | 0.87A | 5kb6B-3oq4A:undetectable | 5kb6B-3oq4A:16.21 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3otx | ADENOSINE KINASE,PUTATIVE (Trypanosomabrucei) |
PF00294(PfkB) | 8 | THR A 264VAL A 283GLN A 288ALA A 297GLY A 298HIS A 323ALA A 326ILE A 330 | AP5 A 346 (-3.6A)AP5 A 346 (-4.1A)AP5 A 346 (-3.1A)AP5 A 346 (-3.4A)AP5 A 346 (-3.2A)AP5 A 346 (-3.8A)AP5 A 346 (-3.0A)AP5 A 346 (-4.9A) | 0.54A | 5kb6B-3otxA:44.8 | 5kb6B-3otxA:40.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ph3 | RIBOSE-5-PHOSPHATEISOMERASE (Ruminiclostridiumthermocellum) |
PF02502(LacAB_rpiB) | 5 | GLY A 61ARG A 60GLY A 46ALA A 75ILE A 81 | None | 0.91A | 5kb6B-3ph3A:undetectable | 5kb6B-3ph3A:20.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qe3 | SORBITOLDEHYDROGENASE (Ovis aries) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 6 | THR A 245ILE A 222ALA A 257GLY A 258ALA A 231ILE A 230 | None | 1.14A | 5kb6B-3qe3A:4.1 | 5kb6B-3qe3A:23.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qe3 | SORBITOLDEHYDROGENASE (Ovis aries) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 6 | THR A 245VAL A 199ILE A 222ALA A 257GLY A 258ILE A 230 | None | 1.15A | 5kb6B-3qe3A:4.1 | 5kb6B-3qe3A:23.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3r0v | ALPHA/BETA HYDROLASEFOLD PROTEIN (Sphaerobacterthermophilus) |
PF12697(Abhydrolase_6) | 5 | GLY A 96ILE A 229ALA A 102ALA A 103ILE A 202 | None | 0.91A | 5kb6B-3r0vA:4.5 | 5kb6B-3r0vA:20.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tqd | 3-DEOXY-MANNO-OCTULOSONATECYTIDYLYLTRANSFERASE (Coxiellaburnetii) |
PF02348(CTP_transf_3) | 5 | ILE A 7ALA A 63GLY A 62ALA A 58ILE A 47 | None | 0.84A | 5kb6B-3tqdA:undetectable | 5kb6B-3tqdA:22.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ubo | ADENOSINE KINASE (Sinorhizobiummeliloti) |
PF00294(PfkB) | 5 | THR A 245ALA A 276GLY A 277ALA A 305ILE A 309 | ADP A 354 (-3.3A)ADP A 354 (-3.4A)ADP A 354 (-3.4A)ADP A 354 (-2.7A)None | 0.58A | 5kb6B-3uboA:35.7 | 5kb6B-3uboA:26.85 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3vas | PUTATIVE ADENOSINEKINASE (Schistosomamansoni) |
PF00294(PfkB) | 7 | THR A 265GLY A 267ILE A 294ALA A 300GLY A 301ALA A 329ILE A 333 | None | 0.61A | 5kb6B-3vasA:45.4 | 5kb6B-3vasA:37.20 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3vas | PUTATIVE ADENOSINEKINASE (Schistosomamansoni) |
PF00294(PfkB) | 7 | THR A 265GLY A 267VAL A 286ALA A 300GLY A 301ALA A 329ILE A 333 | None | 0.40A | 5kb6B-3vasA:45.4 | 5kb6B-3vasA:37.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4e3a | SUGAR KINASE PROTEIN (Rhizobium etli) |
PF00294(PfkB) | 6 | THR A 243ILE A 265ALA A 274GLY A 275ALA A 303ILE A 307 | None | 1.33A | 5kb6B-4e3aA:36.8 | 5kb6B-4e3aA:27.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4e69 | 2-DEHYDRO-3-DEOXYGLUCONOKINASE (Oceanicolagranulosus) |
PF00294(PfkB) | 5 | GLY A 225VAL A 242ALA A 254GLY A 255ALA A 283 | None | 0.35A | 5kb6B-4e69A:31.9 | 5kb6B-4e69A:22.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4f32 | 3-OXOACYL-[ACYL-CARRIER-PROTEIN]SYNTHASE 2 (Burkholderiavietnamiensis) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C) | 5 | GLY A 242ALA A 353GLY A 352ALA A 354ILE A 357 | NoneNoneCSU A 172 ( 4.7A)CSU A 172 ( 4.7A)None | 0.93A | 5kb6B-4f32A:undetectable | 5kb6B-4f32A:22.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fr2 | 1,3-PROPANEDIOLDEHYDROGENASE (Oenococcus oeni) |
PF00465(Fe-ADH) | 5 | GLY A 145ILE A 227ALA A 254GLY A 255HIS A 267 | NoneNoneNoneNone NI A 501 (-3.4A) | 0.90A | 5kb6B-4fr2A:2.5 | 5kb6B-4fr2A:21.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4g1j | SORTASE FAMILYPROTEIN (Streptococcusagalactiae) |
PF04203(Sortase) | 5 | GLY A 181ASP A 252GLN A 258GLY A 239ILE A 242 | None | 0.85A | 5kb6B-4g1jA:undetectable | 5kb6B-4g1jA:22.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4is2 | BILE ACID 3-ALPHAHYDROXYSTEROIDDEHYDROGENASE ([Clostridium]scindens) |
PF00106(adh_short) | 5 | GLY A 17ARG A 16ALA A 22ALA A 23ILE A 11 | None | 0.91A | 5kb6B-4is2A:5.9 | 5kb6B-4is2A:23.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jhy | HYPOTHETICAL PROTEIN (Parabacteroidesdistasonis) |
PF14730(DUF4468) | 5 | THR A 47ILE A 106ALA A 178ALA A 55ILE A 56 | None | 0.87A | 5kb6B-4jhyA:undetectable | 5kb6B-4jhyA:18.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jrm | 3-OXOACYL-[ACYL-CARRIER-PROTEIN]SYNTHASE 2 (Vibrio cholerae) |
no annotation | 5 | GLY D 172ILE D 178ALA D 188GLY D 189ALA D 104 | None | 0.86A | 5kb6B-4jrmD:undetectable | 5kb6B-4jrmD:22.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kpg | MEMBRANE-ANCHOREDMYCOSIN MYCP1 (Mycolicibacteriumsmegmatis) |
PF00082(Peptidase_S8) | 5 | GLY A 195ALA A 231GLY A 230ALA A 225ILE A 199 | None | 0.91A | 5kb6B-4kpgA:3.8 | 5kb6B-4kpgA:22.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kys | THIAMINEPYRIDINYLASE I (Clostridiumbotulinum) |
PF01547(SBP_bac_1) | 5 | ILE A 267ALA A 237GLY A 238ALA A 242ILE A 187 | None | 0.88A | 5kb6B-4kysA:undetectable | 5kb6B-4kysA:21.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lb0 | UNCHARACTERIZEDPROTEIN (Agrobacteriumvitis) |
PF05544(Pro_racemase) | 5 | THR A 257GLY A 173VAL A 147ALA A 91ILE A 222 | ACT A 401 (-2.8A)NoneNoneNoneNone | 0.85A | 5kb6B-4lb0A:undetectable | 5kb6B-4lb0A:24.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lmp | ALANINEDEHYDROGENASE (Mycobacteriumtuberculosis) |
PF01262(AlaDh_PNT_C)PF05222(AlaDh_PNT_N) | 5 | GLY A 22ILE A 5ALA A 55GLY A 54ILE A 35 | None | 0.77A | 5kb6B-4lmpA:5.2 | 5kb6B-4lmpA:21.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ls5 | 3-OXOACYL-[ACYL-CARRIER-PROTEIN]SYNTHASE 2 (Bacillussubtilis) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C) | 5 | GLY A 231ALA A 343GLY A 342ALA A 344ILE A 347 | None | 0.84A | 5kb6B-4ls5A:undetectable | 5kb6B-4ls5A:21.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4m1z | MEMBRANE-ANCHOREDMYCOSIN MYCP1 (Mycolicibacteriumsmegmatis) |
PF00082(Peptidase_S8) | 5 | GLY A 195ALA A 231GLY A 230ALA A 225ILE A 199 | None | 0.92A | 5kb6B-4m1zA:3.7 | 5kb6B-4m1zA:22.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4my0 | GCN5-RELATEDN-ACETYLTRANSFERASE (Kribbellaflavida) |
PF13527(Acetyltransf_9)PF13530(SCP2_2) | 6 | THR A 352GLY A 134GLN A 70ILE A 115ALA A 346GLY A 344 | None | 1.46A | 5kb6B-4my0A:undetectable | 5kb6B-4my0A:22.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mzy | NICOTINATEPHOSPHORIBOSYLTRANSFERASE (Enterococcusfaecalis) |
PF04095(NAPRTase) | 5 | GLY A 55ILE A 436ALA A 177ALA A 142ILE A 180 | NoneGOL A 504 ( 4.3A)NoneNoneNone | 0.82A | 5kb6B-4mzyA:undetectable | 5kb6B-4mzyA:23.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ns4 | ALPHA/BETA HYDROLASEFOLD PROTEIN (Psychrobactercryohalolentis) |
PF00561(Abhydrolase_1) | 5 | VAL A 216ILE A 253ALA A 126ALA A 127ILE A 223 | None | 0.94A | 5kb6B-4ns4A:undetectable | 5kb6B-4ns4A:24.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4olq | ENOYL-COAHYDRATASE/ISOMERASEFAMILY PROTEIN (Hyphomonasneptunium) |
PF00378(ECH_1) | 5 | GLY A 113ILE A 35ALA A 119ALA A 120ILE A 94 | None | 0.91A | 5kb6B-4olqA:undetectable | 5kb6B-4olqA:23.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pvv | ADENOSINE KINASE (Mycobacteriumtuberculosis) |
PF00294(PfkB) | 5 | THR A 223GLY A 225VAL A 243GLY A 256ALA A 284 | None | 0.69A | 5kb6B-4pvvA:26.3 | 5kb6B-4pvvA:22.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q2h | PROLINE RACEMASEPROTEIN (Agrobacteriumtumefaciens) |
PF05544(Pro_racemase) | 5 | THR A 257GLY A 173VAL A 147ALA A 91ILE A 222 | BCT A 401 (-2.8A)NoneNoneNoneNone | 0.88A | 5kb6B-4q2hA:undetectable | 5kb6B-4q2hA:23.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r8e | 3-OXOACYL-[ACYL-CARRIER-PROTEIN]SYNTHASE 2 (Yersinia pestis) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C) | 5 | GLY A 171ILE A 177ALA A 187GLY A 188ALA A 103 | None | 0.91A | 5kb6B-4r8eA:undetectable | 5kb6B-4r8eA:22.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rk6 | GLUCOSE-RESISTANCEAMYLASE REGULATOR (Weissellaparamesenteroides) |
PF13377(Peripla_BP_3) | 5 | GLY A 225VAL A 229ALA A 245ALA A 243ILE A 271 | None | 0.83A | 5kb6B-4rk6A:5.0 | 5kb6B-4rk6A:19.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wjm | RIBOKINASE:CARBOHYDRATE KINASE, PFKB (Brucellaabortus) |
PF00294(PfkB) | 5 | THR A 217GLY A 219ALA A 247GLY A 248ALA A 289 | ANP A 401 (-3.5A)ANP A 401 (-3.6A)ANP A 401 (-3.3A)ANP A 401 (-3.4A)ANP A 401 (-3.5A) | 0.27A | 5kb6B-4wjmA:28.9 | 5kb6B-4wjmA:25.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4x8f | RIBOKINASE (Vibrio cholerae) |
PF00294(PfkB) | 6 | THR A 220GLY A 222ALA A 250GLY A 251HIS A 276ALA A 279 | None | 0.63A | 5kb6B-4x8fA:29.2 | 5kb6B-4x8fA:25.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yji | ARYL ACYLAMIDASE (bacteriumCSBL00001) |
PF01425(Amidase) | 7 | THR A 142GLY A 162ILE A 188ALA A 167GLY A 166ALA A 168ILE A 227 | None | 1.30A | 5kb6B-4yjiA:undetectable | 5kb6B-4yjiA:22.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5c41 | RIBOKINASE (Homo sapiens) |
PF00294(PfkB) | 5 | THR A 235GLY A 237ALA A 267GLY A 268ALA A 298 | ACP A 401 (-3.2A)ACP A 401 (-3.3A)ACP A 401 (-3.5A)ACP A 401 (-3.4A)ACP A 401 (-3.3A) | 0.33A | 5kb6B-5c41A:31.5 | 5kb6B-5c41A:28.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ema | SORTING NEXIN-27 (Rattusnorvegicus) |
PF00595(PDZ) | 5 | GLY A 52ALA A 89GLY A 88ALA A 90ILE A 46 | None | 0.94A | 5kb6B-5emaA:undetectable | 5kb6B-5emaA:16.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5koj | NITROGENASE PROTEINALPHA CHAIN (Gluconacetobacterdiazotrophicus) |
PF00148(Oxidored_nitro) | 5 | GLY A 407ARG A 377ALA A 40GLY A 41ILE A 416 | None | 0.91A | 5kb6B-5kojA:2.5 | 5kb6B-5kojA:22.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m5j | THIOREDOXINREDUCTASE (Giardiaintestinalis) |
PF07992(Pyr_redox_2) | 5 | THR A 32GLY A 10ALA A 21GLY A 22ALA A 303 | None | 0.79A | 5kb6B-5m5jA:undetectable | 5kb6B-5m5jA:20.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xbf | HARMONIN (Homo sapiens) |
PF00595(PDZ) | 5 | ILE B 533ALA B 489GLY B 488ALA B 490ILE B 458 | None | 0.85A | 5kb6B-5xbfB:undetectable | 5kb6B-5xbfB:18.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5y9p | - (-) |
no annotation | 6 | GLN A 180ILE A 169ALA A 156GLY A 133ALA A 93ILE A 77 | None | 1.47A | 5kb6B-5y9pA:undetectable | 5kb6B-5y9pA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6ci7 | YCAO (Methanopyruskandleri) |
no annotation | 5 | GLY A 256VAL A 43ASP A 41ALA A 63ILE A 50 | None | 0.94A | 5kb6B-6ci7A:undetectable | 5kb6B-6ci7A:12.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6h7x | - (-) |
no annotation | 5 | GLY A 89VAL A 295ILE A 75ALA A 56GLY A 57 | EDO A1008 ( 4.2A)NoneNoneNoneNone | 0.90A | 5kb6B-6h7xA:undetectable | 5kb6B-6h7xA:undetectable |