SIMILAR PATTERNS OF AMINO ACIDS FOR 5KB6_A_ADNA401
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1a5l | UREASE (ALPHASUBUNIT) (Klebsiellaaerogenes) |
PF00449(Urease_alpha)PF01979(Amidohydro_1) | 6 | GLY C 129THR C 153ILE C 424ALA C 430GLY C 450ILE C 93 | None | 1.28A | 5kb6A-1a5lC:3.5 | 5kb6A-1a5lC:21.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1a5l | UREASE (ALPHASUBUNIT) (Klebsiellaaerogenes) |
PF00449(Urease_alpha)PF01979(Amidohydro_1) | 6 | THR C 152GLY C 129THR C 153ALA C 430GLY C 450ILE C 93 | None | 1.32A | 5kb6A-1a5lC:3.5 | 5kb6A-1a5lC:21.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1aor | ALDEHYDE FERREDOXINOXIDOREDUCTASE (Pyrococcusfuriosus) |
PF01314(AFOR_C)PF02730(AFOR_N) | 5 | GLY A 190ILE A 61ALA A 184GLY A 185ALA A 92 | NoneNoneNonePTE A 609 (-3.7A)PTE A 609 (-3.0A) | 0.91A | 5kb6A-1aorA:undetectable | 5kb6A-1aorA:22.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1b3n | PROTEIN (KETOACYLACYL CARRIER PROTEINSYNTHASE 2) (Escherichiacoli) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C) | 5 | GLY A 171ILE A 177ALA A 187GLY A 188ALA A 103 | None | 0.89A | 5kb6A-1b3nA:undetectable | 5kb6A-1b3nA:23.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bu2 | CYCLIN HOMOLOG (Saimiriinegammaherpesvirus2) |
PF00134(Cyclin_N)PF09241(Herp-Cyclin) | 5 | THR A 205GLY A 201THR A 206ALA A 184ILE A 190 | None | 0.89A | 5kb6A-1bu2A:undetectable | 5kb6A-1bu2A:20.27 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1dgm | ADENOSINE KINASE (Toxoplasmagondii) |
PF00294(PfkB) | 8 | THR A 278GLY A 280VAL A 302ILE A 310ALA A 316GLY A 317ALA A 345ILE A 349 | NoneNoneNoneNoneACY A 370 (-4.0A)ACY A 370 (-3.5A)NoneNone | 0.63A | 5kb6A-1dgmA:47.3 | 5kb6A-1dgmA:32.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dih | DIHYDRODIPICOLINATEREDUCTASE (Escherichiacoli) |
PF01113(DapB_N)PF05173(DapB_C) | 5 | VAL A 31ILE A 10ALA A 247GLY A 246ILE A 77 | None | 0.82A | 5kb6A-1dihA:5.8 | 5kb6A-1dihA:21.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1im8 | YECO (Haemophilusinfluenzae) |
PF13649(Methyltransf_25) | 5 | THR A 133ALA A 68GLY A 67ALA A 69ILE A 42 | SAI A 302 ( 3.7A)SAI A 302 ( 4.0A)NoneSAI A 302 ( 3.9A)None | 0.87A | 5kb6A-1im8A:3.7 | 5kb6A-1im8A:21.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1j3n | 3-OXOACYL-(ACYL-CARRIER PROTEIN)SYNTHASE II (Thermusthermophilus) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C) | 5 | GLY A 186THR A 163ALA A 75ALA A 140ILE A 144 | None | 0.87A | 5kb6A-1j3nA:undetectable | 5kb6A-1j3nA:22.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ofu | CELL DIVISIONPROTEIN FTSZ (Pseudomonasaeruginosa) |
PF00091(Tubulin)PF12327(FtsZ_C) | 6 | GLY A 20ILE A 17ALA A 113GLY A 112ALA A 114ILE A 117 | GDP A1318 (-3.5A)NoneNoneNoneNoneNone | 1.31A | 5kb6A-1ofuA:8.3 | 5kb6A-1ofuA:21.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ojg | SENSOR PROTEIN DCUS (Escherichiacoli) |
PF17203(sCache_3_2) | 5 | THR A 150ILE A 82ALA A 60ALA A 64ILE A 85 | None | 0.84A | 5kb6A-1ojgA:undetectable | 5kb6A-1ojgA:16.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1p74 | SHIKIMATE5-DEHYDROGENASE (Haemophilusinfluenzae) |
PF01488(Shikimate_DH)PF08501(Shikimate_dh_N) | 5 | GLY A 133ALA A 127GLY A 128ALA A 187ILE A 124 | None | 0.86A | 5kb6A-1p74A:4.0 | 5kb6A-1p74A:21.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pl8 | HUMAN SORBITOLDEHYDROGENASE (Homo sapiens) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 6 | THR A 246ILE A 223ALA A 258GLY A 259ALA A 232ILE A 231 | NoneNAD A 400 ( 4.0A)NoneNoneNoneNone | 1.22A | 5kb6A-1pl8A:5.9 | 5kb6A-1pl8A:24.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pl8 | HUMAN SORBITOLDEHYDROGENASE (Homo sapiens) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 6 | THR A 246VAL A 200ILE A 223ALA A 258GLY A 259ILE A 231 | NoneNoneNAD A 400 ( 4.0A)NoneNoneNone | 1.19A | 5kb6A-1pl8A:5.9 | 5kb6A-1pl8A:24.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rk2 | RIBOKINASE (Escherichiacoli) |
PF00294(PfkB) | 6 | THR A 223GLY A 225ALA A 253GLY A 254HIS A 279ALA A 282 | ADP A 310 (-3.4A)ADP A 310 (-3.7A)ADP A 310 (-3.5A)ADP A 310 (-3.3A)ADP A 310 (-3.6A)ADP A 310 (-3.3A) | 0.36A | 5kb6A-1rk2A:30.8 | 5kb6A-1rk2A:28.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rmg | RHAMNOGALACTURONASEA (Aspergillusaculeatus) |
PF00295(Glyco_hydro_28) | 6 | THR A 64VAL A 66ILE A 55ALA A 28ALA A 39ILE A 23 | None | 1.00A | 5kb6A-1rmgA:undetectable | 5kb6A-1rmgA:19.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1t5o | TRANSLATIONINITIATION FACTOREIF2B, SUBUNIT DELTA (Archaeoglobusfulgidus) |
PF01008(IF-2B) | 5 | GLY A 46GLN A 17ALA A 52ALA A 53ILE A 6 | None | 0.80A | 5kb6A-1t5oA:2.1 | 5kb6A-1t5oA:21.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1td2 | PYRIDOXAMINE KINASE (Escherichiacoli) |
PF08543(Phos_pyr_kin) | 5 | GLY A 223ILE A 254ALA A 21GLY A 18ALA A 22 | NoneNoneNonePXL A 288 ( 4.1A)None | 0.86A | 5kb6A-1td2A:18.3 | 5kb6A-1td2A:22.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1u7w | COENZYME ABIOSYNTHESISBIFUNCTIONAL PROTEINCOABC (Escherichiacoli) |
PF04127(DFP) | 5 | ILE A 270ALA A 229GLY A 228ALA A 224ILE A 191 | None | 0.87A | 5kb6A-1u7wA:3.7 | 5kb6A-1u7wA:23.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v5f | PYRUVATE OXIDASE (Aerococcusviridans) |
PF00205(TPP_enzyme_M)PF02775(TPP_enzyme_C)PF02776(TPP_enzyme_N) | 5 | GLY A 222ALA A 214GLY A 215ALA A 278ILE A 212 | NoneNoneFAD A1601 (-2.9A)NoneNone | 0.91A | 5kb6A-1v5fA:3.0 | 5kb6A-1v5fA:22.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vic | 3-DEOXY-MANNO-OCTULOSONATECYTIDYLYLTRANSFERASE (Haemophilusinfluenzae) |
PF02348(CTP_transf_3) | 5 | ILE A 7ALA A 63GLY A 62ALA A 58ILE A 47 | None | 0.84A | 5kb6A-1vicA:undetectable | 5kb6A-1vicA:21.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vl8 | GLUCONATE5-DEHYDROGENASE (Thermotogamaritima) |
PF13561(adh_short_C2) | 5 | GLY A 24ILE A 188ALA A 94GLY A 16ILE A 144 | NoneNoneNAP A 274 (-4.5A)NAP A 274 (-3.2A)NAP A 274 (-4.4A) | 0.87A | 5kb6A-1vl8A:6.7 | 5kb6A-1vl8A:21.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1z82 | GLYCEROL-3-PHOSPHATEDEHYDROGENASE (Thermotogamaritima) |
PF01210(NAD_Gly3P_dh_N)PF07479(NAD_Gly3P_dh_C) | 6 | GLY A 226THR A 143ILE A 207GLY A 171ALA A 175ILE A 210 | None | 1.26A | 5kb6A-1z82A:3.5 | 5kb6A-1z82A:23.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2alb | PROTEINDISULFIDE-ISOMERASEA3 (Homo sapiens) |
PF00085(Thioredoxin) | 6 | THR A 18GLY A 22VAL A 54GLN A 107GLY A 85ILE A 81 | None | 1.21A | 5kb6A-2albA:undetectable | 5kb6A-2albA:14.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bb0 | IMIDAZOLONEPROPIONASE (Bacillussubtilis) |
PF01979(Amidohydro_1) | 5 | GLY A 257ALA A 262GLY A 263ALA A 270ILE A 248 | None | 0.88A | 5kb6A-2bb0A:undetectable | 5kb6A-2bb0A:22.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2c49 | SUGAR KINASE MJ0406 (Methanocaldococcusjannaschii) |
PF00294(PfkB) | 5 | THR A 214GLY A 216ALA A 245GLY A 246ALA A 274 | ANP A1304 (-3.4A)ANP A1304 (-3.4A)ANP A1304 (-3.5A)ANP A1304 (-3.2A)ANP A1304 (-3.1A) | 0.38A | 5kb6A-2c49A:25.4 | 5kb6A-2c49A:27.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2c5a | GDP-MANNOSE-3',5'-EPIMERASE (Arabidopsisthaliana) |
PF01370(Epimerase) | 5 | ALA A 35GLY A 36HIS A 42ALA A 40ILE A 32 | NoneNAD A1378 (-4.1A)NoneNoneNone | 0.89A | 5kb6A-2c5aA:6.0 | 5kb6A-2c5aA:21.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2d1q | LUCIFERIN4-MONOOXYGENASE (Luciolacruciata) |
PF00501(AMP-binding)PF13193(AMP-binding_C) | 5 | GLY A 317THR A 529VAL A 243ALA A 350GLY A 343 | AMP A1001 ( 4.3A)AMP A1001 ( 4.7A)NoneNoneNone | 0.91A | 5kb6A-2d1qA:undetectable | 5kb6A-2d1qA:21.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2i14 | NICOTINATE-NUCLEOTIDE PYROPHOSPHORYLASE (Pyrococcusfuriosus) |
PF01729(QRPTase_C)PF02749(QRPTase_N) | 5 | GLY A 58ILE A 374ALA A 150ALA A 116ILE A 153 | None | 0.91A | 5kb6A-2i14A:undetectable | 5kb6A-2i14A:23.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2i5b | PHOSPHOMETHYLPYRIMIDINE KINASE (Bacillussubtilis) |
PF08543(Phos_pyr_kin) | 5 | THR A 178GLY A 180ALA A 214GLY A 215ILE A 247 | ADP A 301 (-3.5A)ADP A 301 (-3.5A)ADP A 301 (-3.6A)ADP A 301 (-3.2A)ADP A 301 (-4.3A) | 0.79A | 5kb6A-2i5bA:18.8 | 5kb6A-2i5bA:24.67 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2i6b | ADENOSINE KINASE (Homo sapiens) |
PF00294(PfkB) | 8 | THR A 265GLY A 267THR A 271VAL A 284ILE A 293ALA A 298HIS A 324ALA A 327 | None | 0.82A | 5kb6A-2i6bA:52.0 | 5kb6A-2i6bA:86.98 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2i6b | ADENOSINE KINASE (Homo sapiens) |
PF00294(PfkB) | 8 | THR A 265THR A 271VAL A 284ILE A 293ALA A 298GLY A 299HIS A 324ALA A 327 | None | 0.77A | 5kb6A-2i6bA:52.0 | 5kb6A-2i6bA:86.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2is8 | MOLYBDOPTERINBIOSYNTHESIS ENZYME,MOAB (Thermusthermophilus) |
PF00994(MoCF_biosynth) | 6 | GLY A 70ASP A 20ILE A 6ALA A 135GLY A 134ILE A 26 | NoneFMT A1003 (-3.7A)NoneNoneNoneNone | 1.31A | 5kb6A-2is8A:undetectable | 5kb6A-2is8A:18.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2iwz | 3-OXOACYL-[ACYL-CARRIER-PROTEIN]SYNTHASE (Homo sapiens) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C) | 6 | GLY A 217ILE A 223ALA A 233GLY A 234HIS A 203ALA A 149 | None | 1.11A | 5kb6A-2iwzA:undetectable | 5kb6A-2iwzA:23.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2mt4 | TRANSCRIPTIONTERMINATION/ANTITERMINATION PROTEIN NUSA (Bacillussubtilis) |
PF08529(NusA_N) | 5 | GLY A 54ILE A 27ALA A 106GLY A 103ALA A 107 | None | 0.91A | 5kb6A-2mt4A:undetectable | 5kb6A-2mt4A:20.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2n76 | DE NOVO DESIGNEDPROTEIN LFR1 (syntheticconstruct) |
no annotation | 6 | THR A 97VAL A 6ILE A 42ALA A 61ALA A 67ILE A 70 | None | 1.46A | 5kb6A-2n76A:undetectable | 5kb6A-2n76A:16.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2r6r | CELL DIVISIONPROTEIN FTSZ (Aquifexaeolicus) |
PF00091(Tubulin)PF12327(FtsZ_C) | 6 | GLY 1 16ILE 1 13ALA 1 109GLY 1 108ALA 1 110ILE 1 113 | GDP 1 339 (-3.5A)NoneNoneNoneNoneNone | 1.32A | 5kb6A-2r6r1:8.1 | 5kb6A-2r6r1:23.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2r9v | ATP SYNTHASE SUBUNITALPHA (Thermotogamaritima) |
PF00006(ATP-synt_ab)PF00306(ATP-synt_ab_C)PF02874(ATP-synt_ab_N) | 6 | GLY A 113ILE A 96ALA A 242GLY A 243ALA A 245ILE A 130 | None | 1.16A | 5kb6A-2r9vA:2.1 | 5kb6A-2r9vA:21.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rbc | SUGAR KINASE (Agrobacteriumfabrum) |
PF00294(PfkB) | 6 | THR A 220GLY A 222GLN A 243ALA A 252GLY A 253ALA A 281 | EDO A 331 (-3.9A)EDO A 331 (-3.1A)NoneNoneNoneEDO A 331 ( 3.7A) | 1.02A | 5kb6A-2rbcA:29.5 | 5kb6A-2rbcA:24.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vaw | CELL DIVISIONPROTEIN FTSZ (Pseudomonasaeruginosa) |
PF00091(Tubulin)PF12327(FtsZ_C) | 6 | GLY A 20ILE A 17ALA A 113GLY A 112ALA A 114ILE A 117 | GDP A1317 (-3.4A)NoneNoneNoneNoneNone | 1.46A | 5kb6A-2vawA:8.1 | 5kb6A-2vawA:24.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2y6g | XYLANASE (Rhodothermusmarinus) |
PF02018(CBM_4_9) | 5 | GLY A 154ALA A 99GLY A 98ALA A 94ILE A 157 | None | 0.91A | 5kb6A-2y6gA:undetectable | 5kb6A-2y6gA:20.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bf5 | RIBOKINASE RELATEDPROTEIN (Thermoplasmaacidophilum) |
PF00294(PfkB) | 5 | GLY A 198ALA A 225GLY A 226ALA A 254ILE A 258 | PGO A 290 (-3.8A)PGO A 290 ( 4.1A)PGO A 290 ( 4.6A)PGO A 290 ( 3.8A)None | 0.57A | 5kb6A-3bf5A:22.4 | 5kb6A-3bf5A:21.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bf5 | RIBOKINASE RELATEDPROTEIN (Thermoplasmaacidophilum) |
PF00294(PfkB) | 5 | THR A 196GLY A 198ALA A 225GLY A 226ALA A 254 | PGO A 290 (-4.0A)PGO A 290 (-3.8A)PGO A 290 ( 4.1A)PGO A 290 ( 4.6A)PGO A 290 ( 3.8A) | 0.51A | 5kb6A-3bf5A:22.4 | 5kb6A-3bf5A:21.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3d1c | FLAVIN-CONTAININGPUTATIVEMONOOXYGENASE (Staphylococcusaureus) |
PF13738(Pyr_redox_3) | 6 | THR A 128ILE A 302ALA A 7HIS A 130ALA A 131ILE A 134 | None | 1.37A | 5kb6A-3d1cA:undetectable | 5kb6A-3d1cA:20.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3da1 | GLYCEROL-3-PHOSPHATEDEHYDROGENASE (Bacillushalodurans) |
PF01266(DAO)PF16901(DAO_C) | 5 | GLY A 32THR A 173ALA A 227GLY A 25ILE A 369 | NoneNoneNoneFAD A 609 ( 4.0A)None | 0.84A | 5kb6A-3da1A:3.4 | 5kb6A-3da1A:21.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3eq1 | PORPHOBILINOGENDEAMINASE (Homo sapiens) |
PF01379(Porphobil_deam)PF03900(Porphobil_deamC) | 6 | THR A 109GLY A 317GLN A 332ILE A 248GLY A 111ALA A 320 | None | 1.34A | 5kb6A-3eq1A:undetectable | 5kb6A-3eq1A:21.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ewm | UNCHARACTERIZEDSUGAR KINASE PH1459 (Pyrococcushorikoshii) |
PF00294(PfkB) | 5 | THR A 215GLY A 217ALA A 245GLY A 246ALA A 276 | None | 0.56A | 5kb6A-3ewmA:28.3 | 5kb6A-3ewmA:22.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ffs | INOSINE-5-MONOPHOSPHATE DEHYDROGENASE (Cryptosporidiumparvum) |
PF00478(IMPDH) | 5 | GLY A 262ILE A 232ALA A 269ALA A 251ILE A 235 | None | 0.82A | 5kb6A-3ffsA:undetectable | 5kb6A-3ffsA:20.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hea | ARYLESTERASE (Pseudomonasfluorescens) |
PF00561(Abhydrolase_1) | 5 | ILE A 210ALA A 234GLY A 231ALA A 235ILE A 238 | None | 0.90A | 5kb6A-3heaA:undetectable | 5kb6A-3heaA:22.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hpf | MUCONATECYCLOISOMERASE (Oceanobacillusiheyensis) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | ILE A 3GLY A 99HIS A 105ALA A 103ILE A 28 | None | 0.86A | 5kb6A-3hpfA:undetectable | 5kb6A-3hpfA:22.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hs3 | RIBOSE OPERONREPRESSOR (Lactobacillusacidophilus) |
PF13377(Peripla_BP_3) | 6 | GLY A 80VAL A 84ILE A 64HIS A 291ALA A 289ILE A 121 | None | 1.12A | 5kb6A-3hs3A:3.6 | 5kb6A-3hs3A:21.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i3y | CARBOHYDRATE KINASE (Klebsiellapneumoniae) |
PF00294(PfkB) | 5 | THR A 200GLY A 202ALA A 230GLY A 231ALA A 261 | None | 0.58A | 5kb6A-3i3yA:26.0 | 5kb6A-3i3yA:23.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kd6 | CARBOHYDRATE KINASE,PFKB FAMILY (Chlorobaculumtepidum) |
PF00294(PfkB) | 5 | GLY A 206ILE A 229ALA A 235GLY A 236ALA A 269 | NoneNoneNoneGOL A 501 ( 3.2A)None | 0.61A | 5kb6A-3kd6A:26.2 | 5kb6A-3kd6A:25.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lhx | KETODEOXYGLUCONOKINASE (Shigellaflexneri) |
PF00294(PfkB) | 6 | GLY A 303ALA A 335GLY A 336HIS A 361ALA A 364ILE A 368 | None | 0.50A | 5kb6A-3lhxA:31.4 | 5kb6A-3lhxA:23.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lm6 | STAGE V SPORULATIONPROTEIN AD (Bacillussubtilis) |
PF07451(SpoVAD) | 6 | GLY A 202THR A 162ILE A 195ALA A 309GLY A 308ILE A 322 | None | 1.35A | 5kb6A-3lm6A:undetectable | 5kb6A-3lm6A:21.55 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3loo | ANOPHELES GAMBIAEADENOSINE KINASE (Anophelesgambiae) |
PF00294(PfkB) | 7 | THR A 263GLY A 265VAL A 284ALA A 298GLY A 299ALA A 327ILE A 331 | B4P A 349 (-3.5A)B4P A 349 (-3.6A)NoneB4P A 349 (-3.3A)B4P A 349 (-3.3A)B4P A 349 (-3.4A)None | 0.48A | 5kb6A-3looA:46.2 | 5kb6A-3looA:48.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3m1a | PUTATIVEDEHYDROGENASE (Streptomycesavermitilis) |
PF00106(adh_short) | 5 | GLY A 18VAL A 10ILE A 232ALA A 24ALA A 25 | None | 0.84A | 5kb6A-3m1aA:6.0 | 5kb6A-3m1aA:24.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mnd | SUPEROXIDE DISMUTASE[CU-ZN] (Taenia solium) |
PF00080(Sod_Cu) | 5 | GLY A 34ILE A 116ALA A 86GLY A 87ALA A 92 | None | 0.91A | 5kb6A-3mndA:undetectable | 5kb6A-3mndA:20.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3oq0 | DBF4 (Saccharomycescerevisiae) |
PF08630(Dfp1_Him1_M) | 5 | GLY A 154ILE A 174ALA A 160GLY A 159ILE A 126 | None | 0.91A | 5kb6A-3oq0A:undetectable | 5kb6A-3oq0A:18.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3oq4 | DBF4 (Saccharomycescerevisiae) |
PF08630(Dfp1_Him1_M) | 5 | GLY A 154ILE A 174ALA A 160GLY A 159ILE A 126 | None | 0.90A | 5kb6A-3oq4A:undetectable | 5kb6A-3oq4A:16.21 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3otx | ADENOSINE KINASE,PUTATIVE (Trypanosomabrucei) |
PF00294(PfkB) | 9 | THR A 264THR A 270VAL A 283GLN A 288ALA A 297GLY A 298HIS A 323ALA A 326ILE A 330 | AP5 A 346 (-3.6A)AP5 A 346 (-4.5A)AP5 A 346 (-4.1A)AP5 A 346 (-3.1A)AP5 A 346 (-3.4A)AP5 A 346 (-3.2A)AP5 A 346 (-3.8A)AP5 A 346 (-3.0A)AP5 A 346 (-4.9A) | 0.51A | 5kb6A-3otxA:44.6 | 5kb6A-3otxA:40.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qe3 | SORBITOLDEHYDROGENASE (Ovis aries) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 6 | THR A 245ILE A 222ALA A 257GLY A 258ALA A 231ILE A 230 | None | 1.13A | 5kb6A-3qe3A:5.4 | 5kb6A-3qe3A:23.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qe3 | SORBITOLDEHYDROGENASE (Ovis aries) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 6 | THR A 245VAL A 199ILE A 222ALA A 257GLY A 258ILE A 230 | None | 1.16A | 5kb6A-3qe3A:5.4 | 5kb6A-3qe3A:23.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ry7 | RIBOKINASE (Staphylococcusaureus) |
PF00294(PfkB) | 5 | THR A 222GLY A 224THR A 228ALA A 252GLY A 253 | None | 0.70A | 5kb6A-3ry7A:27.6 | 5kb6A-3ry7A:26.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tgw | V-TYPE ATP SYNTHASEBETA CHAIN (Methanosarcinamazei) |
PF00006(ATP-synt_ab)PF02874(ATP-synt_ab_N) | 5 | GLY A 35THR A 38ILE A 110ALA A 114ALA A 113 | GOL A 463 (-3.5A)NoneNoneGOL A 463 (-4.2A)GOL A 465 ( 3.5A) | 0.85A | 5kb6A-3tgwA:undetectable | 5kb6A-3tgwA:22.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tqd | 3-DEOXY-MANNO-OCTULOSONATECYTIDYLYLTRANSFERASE (Coxiellaburnetii) |
PF02348(CTP_transf_3) | 5 | ILE A 7ALA A 63GLY A 62ALA A 58ILE A 47 | None | 0.82A | 5kb6A-3tqdA:undetectable | 5kb6A-3tqdA:22.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ubo | ADENOSINE KINASE (Sinorhizobiummeliloti) |
PF00294(PfkB) | 5 | THR A 245ALA A 276GLY A 277ALA A 305ILE A 309 | ADP A 354 (-3.3A)ADP A 354 (-3.4A)ADP A 354 (-3.4A)ADP A 354 (-2.7A)None | 0.59A | 5kb6A-3uboA:35.5 | 5kb6A-3uboA:26.85 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3vas | PUTATIVE ADENOSINEKINASE (Schistosomamansoni) |
PF00294(PfkB) | 7 | THR A 265GLY A 267ILE A 294ALA A 300GLY A 301ALA A 329ILE A 333 | None | 0.65A | 5kb6A-3vasA:45.2 | 5kb6A-3vasA:37.20 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3vas | PUTATIVE ADENOSINEKINASE (Schistosomamansoni) |
PF00294(PfkB) | 7 | THR A 265GLY A 267VAL A 286ALA A 300GLY A 301ALA A 329ILE A 333 | None | 0.39A | 5kb6A-3vasA:45.2 | 5kb6A-3vasA:37.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4e3a | SUGAR KINASE PROTEIN (Rhizobium etli) |
PF00294(PfkB) | 5 | THR A 243ALA A 274GLY A 275ALA A 303ILE A 307 | None | 0.36A | 5kb6A-4e3aA:36.7 | 5kb6A-4e3aA:27.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4e69 | 2-DEHYDRO-3-DEOXYGLUCONOKINASE (Oceanicolagranulosus) |
PF00294(PfkB) | 5 | GLY A 225VAL A 242ALA A 254GLY A 255ALA A 283 | None | 0.31A | 5kb6A-4e69A:14.7 | 5kb6A-4e69A:22.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fr2 | 1,3-PROPANEDIOLDEHYDROGENASE (Oenococcus oeni) |
PF00465(Fe-ADH) | 5 | GLY A 145ILE A 227ALA A 254GLY A 255HIS A 267 | NoneNoneNoneNone NI A 501 (-3.4A) | 0.88A | 5kb6A-4fr2A:3.6 | 5kb6A-4fr2A:21.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gek | TRNA(CMO5U34)-METHYLTRANSFERASE (Escherichiacoli) |
PF13649(Methyltransf_25) | 5 | THR A 134ALA A 69GLY A 68ALA A 70ILE A 43 | GEK A 302 ( 3.8A)SO4 A 301 (-3.7A)NoneGEK A 302 ( 4.1A)None | 0.86A | 5kb6A-4gekA:3.9 | 5kb6A-4gekA:20.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4iwn | TRNA(CMO5U34)-METHYLTRANSFERASE (Escherichiacoli) |
PF13649(Methyltransf_25) | 5 | THR A 134ALA A 69GLY A 68ALA A 70ILE A 43 | GEK A 301 ( 3.8A)GEK A 301 (-3.6A)NoneGEK A 301 ( 4.1A)None | 0.90A | 5kb6A-4iwnA:3.8 | 5kb6A-4iwnA:20.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jhy | HYPOTHETICAL PROTEIN (Parabacteroidesdistasonis) |
PF14730(DUF4468) | 5 | THR A 47ILE A 106ALA A 178ALA A 55ILE A 56 | None | 0.89A | 5kb6A-4jhyA:undetectable | 5kb6A-4jhyA:18.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jrm | 3-OXOACYL-[ACYL-CARRIER-PROTEIN]SYNTHASE 2 (Vibrio cholerae) |
no annotation | 5 | GLY D 172ILE D 178ALA D 188GLY D 189ALA D 104 | None | 0.89A | 5kb6A-4jrmD:undetectable | 5kb6A-4jrmD:22.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kys | THIAMINEPYRIDINYLASE I (Clostridiumbotulinum) |
PF01547(SBP_bac_1) | 5 | ILE A 267ALA A 237GLY A 238ALA A 242ILE A 187 | None | 0.89A | 5kb6A-4kysA:undetectable | 5kb6A-4kysA:21.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lb0 | UNCHARACTERIZEDPROTEIN (Agrobacteriumvitis) |
PF05544(Pro_racemase) | 5 | THR A 257GLY A 173VAL A 147ALA A 91ILE A 222 | ACT A 401 (-2.8A)NoneNoneNoneNone | 0.86A | 5kb6A-4lb0A:undetectable | 5kb6A-4lb0A:24.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lmp | ALANINEDEHYDROGENASE (Mycobacteriumtuberculosis) |
PF01262(AlaDh_PNT_C)PF05222(AlaDh_PNT_N) | 5 | GLY A 22ILE A 5ALA A 55GLY A 54ILE A 35 | None | 0.73A | 5kb6A-4lmpA:5.3 | 5kb6A-4lmpA:21.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ls5 | 3-OXOACYL-[ACYL-CARRIER-PROTEIN]SYNTHASE 2 (Bacillussubtilis) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C) | 5 | GLY A 188THR A 165ALA A 77ALA A 142ILE A 146 | None | 0.72A | 5kb6A-4ls5A:undetectable | 5kb6A-4ls5A:21.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ls5 | 3-OXOACYL-[ACYL-CARRIER-PROTEIN]SYNTHASE 2 (Bacillussubtilis) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C) | 5 | GLY A 231ALA A 343GLY A 342ALA A 344ILE A 347 | None | 0.85A | 5kb6A-4ls5A:undetectable | 5kb6A-4ls5A:21.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4my0 | GCN5-RELATEDN-ACETYLTRANSFERASE (Kribbellaflavida) |
PF13527(Acetyltransf_9)PF13530(SCP2_2) | 6 | THR A 352GLY A 134GLN A 70ILE A 115ALA A 346GLY A 344 | None | 1.46A | 5kb6A-4my0A:undetectable | 5kb6A-4my0A:22.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mzy | NICOTINATEPHOSPHORIBOSYLTRANSFERASE (Enterococcusfaecalis) |
PF04095(NAPRTase) | 5 | GLY A 55ILE A 436ALA A 177ALA A 142ILE A 180 | NoneGOL A 504 ( 4.3A)NoneNoneNone | 0.81A | 5kb6A-4mzyA:2.9 | 5kb6A-4mzyA:23.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pvv | ADENOSINE KINASE (Mycobacteriumtuberculosis) |
PF00294(PfkB) | 5 | THR A 223GLY A 225VAL A 243GLY A 256ALA A 284 | None | 0.67A | 5kb6A-4pvvA:26.2 | 5kb6A-4pvvA:22.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q2h | PROLINE RACEMASEPROTEIN (Agrobacteriumtumefaciens) |
PF05544(Pro_racemase) | 5 | THR A 257GLY A 173VAL A 147ALA A 91ILE A 222 | BCT A 401 (-2.8A)NoneNoneNoneNone | 0.88A | 5kb6A-4q2hA:undetectable | 5kb6A-4q2hA:23.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rk6 | GLUCOSE-RESISTANCEAMYLASE REGULATOR (Weissellaparamesenteroides) |
PF13377(Peripla_BP_3) | 5 | GLY A 225VAL A 229ALA A 245ALA A 243ILE A 271 | None | 0.83A | 5kb6A-4rk6A:6.0 | 5kb6A-4rk6A:19.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wjm | RIBOKINASE:CARBOHYDRATE KINASE, PFKB (Brucellaabortus) |
PF00294(PfkB) | 5 | THR A 217GLY A 219ALA A 247GLY A 248ALA A 289 | ANP A 401 (-3.5A)ANP A 401 (-3.6A)ANP A 401 (-3.3A)ANP A 401 (-3.4A)ANP A 401 (-3.5A) | 0.28A | 5kb6A-4wjmA:28.8 | 5kb6A-4wjmA:25.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4x8f | RIBOKINASE (Vibrio cholerae) |
PF00294(PfkB) | 6 | THR A 220GLY A 222ALA A 250GLY A 251HIS A 276ALA A 279 | None | 0.64A | 5kb6A-4x8fA:29.2 | 5kb6A-4x8fA:25.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yji | ARYL ACYLAMIDASE (bacteriumCSBL00001) |
PF01425(Amidase) | 6 | THR A 142GLY A 162ALA A 167GLY A 166ALA A 168ILE A 227 | None | 1.14A | 5kb6A-4yjiA:undetectable | 5kb6A-4yjiA:22.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yji | ARYL ACYLAMIDASE (bacteriumCSBL00001) |
PF01425(Amidase) | 6 | THR A 142GLY A 162ILE A 188ALA A 167GLY A 166ALA A 168 | None | 1.26A | 5kb6A-4yjiA:undetectable | 5kb6A-4yjiA:22.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5c41 | RIBOKINASE (Homo sapiens) |
PF00294(PfkB) | 5 | THR A 235GLY A 237ALA A 267GLY A 268ALA A 298 | ACP A 401 (-3.2A)ACP A 401 (-3.3A)ACP A 401 (-3.5A)ACP A 401 (-3.4A)ACP A 401 (-3.3A) | 0.36A | 5kb6A-5c41A:31.5 | 5kb6A-5c41A:28.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cvo | WD REPEAT-CONTAININGPROTEIN 48 (Homo sapiens) |
PF00400(WD40) | 5 | GLY A 186THR A 188ALA A 135GLY A 136ILE A 141 | None | 0.91A | 5kb6A-5cvoA:undetectable | 5kb6A-5cvoA:20.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dx5 | METHIONINEGAMMA-LYASE (Clostridiumsporogenes) |
PF01053(Cys_Met_Meta_PP) | 6 | THR A 244GLY A 239ILE A 232ALA A 91GLY A 90ALA A 85 | None | 1.10A | 5kb6A-5dx5A:undetectable | 5kb6A-5dx5A:20.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h6s | AMIDASE (Microbacteriumsp. HM58-2) |
PF01425(Amidase) | 6 | GLY A 154THR A 151ILE A 180GLY A 158ALA A 160ILE A 223 | None | 1.45A | 5kb6A-5h6sA:undetectable | 5kb6A-5h6sA:21.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jy9 | PUTATIVE SALICYLATESYNTHETASE (Yersiniaenterocolitica) |
PF00425(Chorismate_bind) | 6 | THR A 258VAL A 319ILE A 428ALA A 404GLY A 405HIS A 321 | ACT A 503 (-3.7A)NoneNoneACT A 502 (-3.8A)ACT A 502 (-3.4A)ACT A 503 ( 4.1A) | 1.44A | 5kb6A-5jy9A:undetectable | 5kb6A-5jy9A:22.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m5j | THIOREDOXINREDUCTASE (Giardiaintestinalis) |
PF07992(Pyr_redox_2) | 5 | THR A 32GLY A 10ALA A 21GLY A 22ALA A 303 | None | 0.79A | 5kb6A-5m5jA:3.6 | 5kb6A-5m5jA:20.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uju | NAD-DEPENDENTALDEHYDEDEHYDROGENASE (Burkholderiamultivorans) |
PF00171(Aldedh) | 6 | THR A 321THR A 358ILE A 349ALA A 328ALA A 371ILE A 372 | None | 1.31A | 5kb6A-5ujuA:undetectable | 5kb6A-5ujuA:22.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xbf | HARMONIN (Homo sapiens) |
PF00595(PDZ) | 5 | ILE B 533ALA B 489GLY B 488ALA B 490ILE B 458 | None | 0.84A | 5kb6A-5xbfB:undetectable | 5kb6A-5xbfB:18.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5y9p | - (-) |
no annotation | 6 | GLN A 180ILE A 169ALA A 156GLY A 133ALA A 93ILE A 77 | None | 1.47A | 5kb6A-5y9pA:undetectable | 5kb6A-5y9pA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6h7x | - (-) |
no annotation | 5 | GLY A 89VAL A 295ILE A 75ALA A 56GLY A 57 | EDO A1008 ( 4.2A)NoneNoneNoneNone | 0.90A | 5kb6A-6h7xA:undetectable | 5kb6A-6h7xA:undetectable |