SIMILAR PATTERNS OF AMINO ACIDS FOR 5KB6_A_ADNA401

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a5l UREASE (ALPHA
SUBUNIT)


(Klebsiella
aerogenes)
PF00449
(Urease_alpha)
PF01979
(Amidohydro_1)
6 GLY C 129
THR C 153
ILE C 424
ALA C 430
GLY C 450
ILE C  93
None
1.28A 5kb6A-1a5lC:
3.5
5kb6A-1a5lC:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a5l UREASE (ALPHA
SUBUNIT)


(Klebsiella
aerogenes)
PF00449
(Urease_alpha)
PF01979
(Amidohydro_1)
6 THR C 152
GLY C 129
THR C 153
ALA C 430
GLY C 450
ILE C  93
None
1.32A 5kb6A-1a5lC:
3.5
5kb6A-1a5lC:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aor ALDEHYDE FERREDOXIN
OXIDOREDUCTASE


(Pyrococcus
furiosus)
PF01314
(AFOR_C)
PF02730
(AFOR_N)
5 GLY A 190
ILE A  61
ALA A 184
GLY A 185
ALA A  92
None
None
None
PTE  A 609 (-3.7A)
PTE  A 609 (-3.0A)
0.91A 5kb6A-1aorA:
undetectable
5kb6A-1aorA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b3n PROTEIN (KETOACYL
ACYL CARRIER PROTEIN
SYNTHASE 2)


(Escherichia
coli)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
5 GLY A 171
ILE A 177
ALA A 187
GLY A 188
ALA A 103
None
0.89A 5kb6A-1b3nA:
undetectable
5kb6A-1b3nA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bu2 CYCLIN HOMOLOG

(Saimiriine
gammaherpesvirus
2)
PF00134
(Cyclin_N)
PF09241
(Herp-Cyclin)
5 THR A 205
GLY A 201
THR A 206
ALA A 184
ILE A 190
None
0.89A 5kb6A-1bu2A:
undetectable
5kb6A-1bu2A:
20.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1dgm ADENOSINE KINASE

(Toxoplasma
gondii)
PF00294
(PfkB)
8 THR A 278
GLY A 280
VAL A 302
ILE A 310
ALA A 316
GLY A 317
ALA A 345
ILE A 349
None
None
None
None
ACY  A 370 (-4.0A)
ACY  A 370 (-3.5A)
None
None
0.63A 5kb6A-1dgmA:
47.3
5kb6A-1dgmA:
32.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dih DIHYDRODIPICOLINATE
REDUCTASE


(Escherichia
coli)
PF01113
(DapB_N)
PF05173
(DapB_C)
5 VAL A  31
ILE A  10
ALA A 247
GLY A 246
ILE A  77
None
0.82A 5kb6A-1dihA:
5.8
5kb6A-1dihA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1im8 YECO

(Haemophilus
influenzae)
PF13649
(Methyltransf_25)
5 THR A 133
ALA A  68
GLY A  67
ALA A  69
ILE A  42
SAI  A 302 ( 3.7A)
SAI  A 302 ( 4.0A)
None
SAI  A 302 ( 3.9A)
None
0.87A 5kb6A-1im8A:
3.7
5kb6A-1im8A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j3n 3-OXOACYL-(ACYL-CARR
IER PROTEIN)
SYNTHASE II


(Thermus
thermophilus)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
5 GLY A 186
THR A 163
ALA A  75
ALA A 140
ILE A 144
None
0.87A 5kb6A-1j3nA:
undetectable
5kb6A-1j3nA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ofu CELL DIVISION
PROTEIN FTSZ


(Pseudomonas
aeruginosa)
PF00091
(Tubulin)
PF12327
(FtsZ_C)
6 GLY A  20
ILE A  17
ALA A 113
GLY A 112
ALA A 114
ILE A 117
GDP  A1318 (-3.5A)
None
None
None
None
None
1.31A 5kb6A-1ofuA:
8.3
5kb6A-1ofuA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ojg SENSOR PROTEIN DCUS

(Escherichia
coli)
PF17203
(sCache_3_2)
5 THR A 150
ILE A  82
ALA A  60
ALA A  64
ILE A  85
None
0.84A 5kb6A-1ojgA:
undetectable
5kb6A-1ojgA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p74 SHIKIMATE
5-DEHYDROGENASE


(Haemophilus
influenzae)
PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N)
5 GLY A 133
ALA A 127
GLY A 128
ALA A 187
ILE A 124
None
0.86A 5kb6A-1p74A:
4.0
5kb6A-1p74A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pl8 HUMAN SORBITOL
DEHYDROGENASE


(Homo sapiens)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
6 THR A 246
ILE A 223
ALA A 258
GLY A 259
ALA A 232
ILE A 231
None
NAD  A 400 ( 4.0A)
None
None
None
None
1.22A 5kb6A-1pl8A:
5.9
5kb6A-1pl8A:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pl8 HUMAN SORBITOL
DEHYDROGENASE


(Homo sapiens)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
6 THR A 246
VAL A 200
ILE A 223
ALA A 258
GLY A 259
ILE A 231
None
None
NAD  A 400 ( 4.0A)
None
None
None
1.19A 5kb6A-1pl8A:
5.9
5kb6A-1pl8A:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rk2 RIBOKINASE

(Escherichia
coli)
PF00294
(PfkB)
6 THR A 223
GLY A 225
ALA A 253
GLY A 254
HIS A 279
ALA A 282
ADP  A 310 (-3.4A)
ADP  A 310 (-3.7A)
ADP  A 310 (-3.5A)
ADP  A 310 (-3.3A)
ADP  A 310 (-3.6A)
ADP  A 310 (-3.3A)
0.36A 5kb6A-1rk2A:
30.8
5kb6A-1rk2A:
28.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rmg RHAMNOGALACTURONASE
A


(Aspergillus
aculeatus)
PF00295
(Glyco_hydro_28)
6 THR A  64
VAL A  66
ILE A  55
ALA A  28
ALA A  39
ILE A  23
None
1.00A 5kb6A-1rmgA:
undetectable
5kb6A-1rmgA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t5o TRANSLATION
INITIATION FACTOR
EIF2B, SUBUNIT DELTA


(Archaeoglobus
fulgidus)
PF01008
(IF-2B)
5 GLY A  46
GLN A  17
ALA A  52
ALA A  53
ILE A   6
None
0.80A 5kb6A-1t5oA:
2.1
5kb6A-1t5oA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1td2 PYRIDOXAMINE KINASE

(Escherichia
coli)
PF08543
(Phos_pyr_kin)
5 GLY A 223
ILE A 254
ALA A  21
GLY A  18
ALA A  22
None
None
None
PXL  A 288 ( 4.1A)
None
0.86A 5kb6A-1td2A:
18.3
5kb6A-1td2A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u7w COENZYME A
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
COABC


(Escherichia
coli)
PF04127
(DFP)
5 ILE A 270
ALA A 229
GLY A 228
ALA A 224
ILE A 191
None
0.87A 5kb6A-1u7wA:
3.7
5kb6A-1u7wA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v5f PYRUVATE OXIDASE

(Aerococcus
viridans)
PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
5 GLY A 222
ALA A 214
GLY A 215
ALA A 278
ILE A 212
None
None
FAD  A1601 (-2.9A)
None
None
0.91A 5kb6A-1v5fA:
3.0
5kb6A-1v5fA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vic 3-DEOXY-MANNO-OCTULO
SONATE
CYTIDYLYLTRANSFERASE


(Haemophilus
influenzae)
PF02348
(CTP_transf_3)
5 ILE A   7
ALA A  63
GLY A  62
ALA A  58
ILE A  47
None
0.84A 5kb6A-1vicA:
undetectable
5kb6A-1vicA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vl8 GLUCONATE
5-DEHYDROGENASE


(Thermotoga
maritima)
PF13561
(adh_short_C2)
5 GLY A  24
ILE A 188
ALA A  94
GLY A  16
ILE A 144
None
None
NAP  A 274 (-4.5A)
NAP  A 274 (-3.2A)
NAP  A 274 (-4.4A)
0.87A 5kb6A-1vl8A:
6.7
5kb6A-1vl8A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z82 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE


(Thermotoga
maritima)
PF01210
(NAD_Gly3P_dh_N)
PF07479
(NAD_Gly3P_dh_C)
6 GLY A 226
THR A 143
ILE A 207
GLY A 171
ALA A 175
ILE A 210
None
1.26A 5kb6A-1z82A:
3.5
5kb6A-1z82A:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2alb PROTEIN
DISULFIDE-ISOMERASE
A3


(Homo sapiens)
PF00085
(Thioredoxin)
6 THR A  18
GLY A  22
VAL A  54
GLN A 107
GLY A  85
ILE A  81
None
1.21A 5kb6A-2albA:
undetectable
5kb6A-2albA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bb0 IMIDAZOLONEPROPIONAS
E


(Bacillus
subtilis)
PF01979
(Amidohydro_1)
5 GLY A 257
ALA A 262
GLY A 263
ALA A 270
ILE A 248
None
0.88A 5kb6A-2bb0A:
undetectable
5kb6A-2bb0A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c49 SUGAR KINASE MJ0406

(Methanocaldococcus
jannaschii)
PF00294
(PfkB)
5 THR A 214
GLY A 216
ALA A 245
GLY A 246
ALA A 274
ANP  A1304 (-3.4A)
ANP  A1304 (-3.4A)
ANP  A1304 (-3.5A)
ANP  A1304 (-3.2A)
ANP  A1304 (-3.1A)
0.38A 5kb6A-2c49A:
25.4
5kb6A-2c49A:
27.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c5a GDP-MANNOSE-3',
5'-EPIMERASE


(Arabidopsis
thaliana)
PF01370
(Epimerase)
5 ALA A  35
GLY A  36
HIS A  42
ALA A  40
ILE A  32
None
NAD  A1378 (-4.1A)
None
None
None
0.89A 5kb6A-2c5aA:
6.0
5kb6A-2c5aA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d1q LUCIFERIN
4-MONOOXYGENASE


(Luciola
cruciata)
PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
5 GLY A 317
THR A 529
VAL A 243
ALA A 350
GLY A 343
AMP  A1001 ( 4.3A)
AMP  A1001 ( 4.7A)
None
None
None
0.91A 5kb6A-2d1qA:
undetectable
5kb6A-2d1qA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i14 NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE


(Pyrococcus
furiosus)
PF01729
(QRPTase_C)
PF02749
(QRPTase_N)
5 GLY A  58
ILE A 374
ALA A 150
ALA A 116
ILE A 153
None
0.91A 5kb6A-2i14A:
undetectable
5kb6A-2i14A:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i5b PHOSPHOMETHYLPYRIMID
INE KINASE


(Bacillus
subtilis)
PF08543
(Phos_pyr_kin)
5 THR A 178
GLY A 180
ALA A 214
GLY A 215
ILE A 247
ADP  A 301 (-3.5A)
ADP  A 301 (-3.5A)
ADP  A 301 (-3.6A)
ADP  A 301 (-3.2A)
ADP  A 301 (-4.3A)
0.79A 5kb6A-2i5bA:
18.8
5kb6A-2i5bA:
24.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2i6b ADENOSINE KINASE

(Homo sapiens)
PF00294
(PfkB)
8 THR A 265
GLY A 267
THR A 271
VAL A 284
ILE A 293
ALA A 298
HIS A 324
ALA A 327
None
0.82A 5kb6A-2i6bA:
52.0
5kb6A-2i6bA:
86.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2i6b ADENOSINE KINASE

(Homo sapiens)
PF00294
(PfkB)
8 THR A 265
THR A 271
VAL A 284
ILE A 293
ALA A 298
GLY A 299
HIS A 324
ALA A 327
None
0.77A 5kb6A-2i6bA:
52.0
5kb6A-2i6bA:
86.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2is8 MOLYBDOPTERIN
BIOSYNTHESIS ENZYME,
MOAB


(Thermus
thermophilus)
PF00994
(MoCF_biosynth)
6 GLY A  70
ASP A  20
ILE A   6
ALA A 135
GLY A 134
ILE A  26
None
FMT  A1003 (-3.7A)
None
None
None
None
1.31A 5kb6A-2is8A:
undetectable
5kb6A-2is8A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iwz 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE


(Homo sapiens)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
6 GLY A 217
ILE A 223
ALA A 233
GLY A 234
HIS A 203
ALA A 149
None
1.11A 5kb6A-2iwzA:
undetectable
5kb6A-2iwzA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mt4 TRANSCRIPTION
TERMINATION/ANTITERM
INATION PROTEIN NUSA


(Bacillus
subtilis)
PF08529
(NusA_N)
5 GLY A  54
ILE A  27
ALA A 106
GLY A 103
ALA A 107
None
0.91A 5kb6A-2mt4A:
undetectable
5kb6A-2mt4A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n76 DE NOVO DESIGNED
PROTEIN LFR1


(synthetic
construct)
no annotation 6 THR A  97
VAL A   6
ILE A  42
ALA A  61
ALA A  67
ILE A  70
None
1.46A 5kb6A-2n76A:
undetectable
5kb6A-2n76A:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r6r CELL DIVISION
PROTEIN FTSZ


(Aquifex
aeolicus)
PF00091
(Tubulin)
PF12327
(FtsZ_C)
6 GLY 1  16
ILE 1  13
ALA 1 109
GLY 1 108
ALA 1 110
ILE 1 113
GDP  1 339 (-3.5A)
None
None
None
None
None
1.32A 5kb6A-2r6r1:
8.1
5kb6A-2r6r1:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r9v ATP SYNTHASE SUBUNIT
ALPHA


(Thermotoga
maritima)
PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N)
6 GLY A 113
ILE A  96
ALA A 242
GLY A 243
ALA A 245
ILE A 130
None
1.16A 5kb6A-2r9vA:
2.1
5kb6A-2r9vA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rbc SUGAR KINASE

(Agrobacterium
fabrum)
PF00294
(PfkB)
6 THR A 220
GLY A 222
GLN A 243
ALA A 252
GLY A 253
ALA A 281
EDO  A 331 (-3.9A)
EDO  A 331 (-3.1A)
None
None
None
EDO  A 331 ( 3.7A)
1.02A 5kb6A-2rbcA:
29.5
5kb6A-2rbcA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vaw CELL DIVISION
PROTEIN FTSZ


(Pseudomonas
aeruginosa)
PF00091
(Tubulin)
PF12327
(FtsZ_C)
6 GLY A  20
ILE A  17
ALA A 113
GLY A 112
ALA A 114
ILE A 117
GDP  A1317 (-3.4A)
None
None
None
None
None
1.46A 5kb6A-2vawA:
8.1
5kb6A-2vawA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y6g XYLANASE

(Rhodothermus
marinus)
PF02018
(CBM_4_9)
5 GLY A 154
ALA A  99
GLY A  98
ALA A  94
ILE A 157
None
0.91A 5kb6A-2y6gA:
undetectable
5kb6A-2y6gA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bf5 RIBOKINASE RELATED
PROTEIN


(Thermoplasma
acidophilum)
PF00294
(PfkB)
5 GLY A 198
ALA A 225
GLY A 226
ALA A 254
ILE A 258
PGO  A 290 (-3.8A)
PGO  A 290 ( 4.1A)
PGO  A 290 ( 4.6A)
PGO  A 290 ( 3.8A)
None
0.57A 5kb6A-3bf5A:
22.4
5kb6A-3bf5A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bf5 RIBOKINASE RELATED
PROTEIN


(Thermoplasma
acidophilum)
PF00294
(PfkB)
5 THR A 196
GLY A 198
ALA A 225
GLY A 226
ALA A 254
PGO  A 290 (-4.0A)
PGO  A 290 (-3.8A)
PGO  A 290 ( 4.1A)
PGO  A 290 ( 4.6A)
PGO  A 290 ( 3.8A)
0.51A 5kb6A-3bf5A:
22.4
5kb6A-3bf5A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d1c FLAVIN-CONTAINING
PUTATIVE
MONOOXYGENASE


(Staphylococcus
aureus)
PF13738
(Pyr_redox_3)
6 THR A 128
ILE A 302
ALA A   7
HIS A 130
ALA A 131
ILE A 134
None
1.37A 5kb6A-3d1cA:
undetectable
5kb6A-3d1cA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3da1 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE


(Bacillus
halodurans)
PF01266
(DAO)
PF16901
(DAO_C)
5 GLY A  32
THR A 173
ALA A 227
GLY A  25
ILE A 369
None
None
None
FAD  A 609 ( 4.0A)
None
0.84A 5kb6A-3da1A:
3.4
5kb6A-3da1A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eq1 PORPHOBILINOGEN
DEAMINASE


(Homo sapiens)
PF01379
(Porphobil_deam)
PF03900
(Porphobil_deamC)
6 THR A 109
GLY A 317
GLN A 332
ILE A 248
GLY A 111
ALA A 320
None
1.34A 5kb6A-3eq1A:
undetectable
5kb6A-3eq1A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ewm UNCHARACTERIZED
SUGAR KINASE PH1459


(Pyrococcus
horikoshii)
PF00294
(PfkB)
5 THR A 215
GLY A 217
ALA A 245
GLY A 246
ALA A 276
None
0.56A 5kb6A-3ewmA:
28.3
5kb6A-3ewmA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ffs INOSINE-5-MONOPHOSPH
ATE DEHYDROGENASE


(Cryptosporidium
parvum)
PF00478
(IMPDH)
5 GLY A 262
ILE A 232
ALA A 269
ALA A 251
ILE A 235
None
0.82A 5kb6A-3ffsA:
undetectable
5kb6A-3ffsA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hea ARYLESTERASE

(Pseudomonas
fluorescens)
PF00561
(Abhydrolase_1)
5 ILE A 210
ALA A 234
GLY A 231
ALA A 235
ILE A 238
None
0.90A 5kb6A-3heaA:
undetectable
5kb6A-3heaA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hpf MUCONATE
CYCLOISOMERASE


(Oceanobacillus
iheyensis)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
5 ILE A   3
GLY A  99
HIS A 105
ALA A 103
ILE A  28
None
0.86A 5kb6A-3hpfA:
undetectable
5kb6A-3hpfA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hs3 RIBOSE OPERON
REPRESSOR


(Lactobacillus
acidophilus)
PF13377
(Peripla_BP_3)
6 GLY A  80
VAL A  84
ILE A  64
HIS A 291
ALA A 289
ILE A 121
None
1.12A 5kb6A-3hs3A:
3.6
5kb6A-3hs3A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i3y CARBOHYDRATE KINASE

(Klebsiella
pneumoniae)
PF00294
(PfkB)
5 THR A 200
GLY A 202
ALA A 230
GLY A 231
ALA A 261
None
0.58A 5kb6A-3i3yA:
26.0
5kb6A-3i3yA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kd6 CARBOHYDRATE KINASE,
PFKB FAMILY


(Chlorobaculum
tepidum)
PF00294
(PfkB)
5 GLY A 206
ILE A 229
ALA A 235
GLY A 236
ALA A 269
None
None
None
GOL  A 501 ( 3.2A)
None
0.61A 5kb6A-3kd6A:
26.2
5kb6A-3kd6A:
25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lhx KETODEOXYGLUCONOKINA
SE


(Shigella
flexneri)
PF00294
(PfkB)
6 GLY A 303
ALA A 335
GLY A 336
HIS A 361
ALA A 364
ILE A 368
None
0.50A 5kb6A-3lhxA:
31.4
5kb6A-3lhxA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm6 STAGE V SPORULATION
PROTEIN AD


(Bacillus
subtilis)
PF07451
(SpoVAD)
6 GLY A 202
THR A 162
ILE A 195
ALA A 309
GLY A 308
ILE A 322
None
1.35A 5kb6A-3lm6A:
undetectable
5kb6A-3lm6A:
21.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3loo ANOPHELES GAMBIAE
ADENOSINE KINASE


(Anopheles
gambiae)
PF00294
(PfkB)
7 THR A 263
GLY A 265
VAL A 284
ALA A 298
GLY A 299
ALA A 327
ILE A 331
B4P  A 349 (-3.5A)
B4P  A 349 (-3.6A)
None
B4P  A 349 (-3.3A)
B4P  A 349 (-3.3A)
B4P  A 349 (-3.4A)
None
0.48A 5kb6A-3looA:
46.2
5kb6A-3looA:
48.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1a PUTATIVE
DEHYDROGENASE


(Streptomyces
avermitilis)
PF00106
(adh_short)
5 GLY A  18
VAL A  10
ILE A 232
ALA A  24
ALA A  25
None
0.84A 5kb6A-3m1aA:
6.0
5kb6A-3m1aA:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mnd SUPEROXIDE DISMUTASE
[CU-ZN]


(Taenia solium)
PF00080
(Sod_Cu)
5 GLY A  34
ILE A 116
ALA A  86
GLY A  87
ALA A  92
None
0.91A 5kb6A-3mndA:
undetectable
5kb6A-3mndA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oq0 DBF4

(Saccharomyces
cerevisiae)
PF08630
(Dfp1_Him1_M)
5 GLY A 154
ILE A 174
ALA A 160
GLY A 159
ILE A 126
None
0.91A 5kb6A-3oq0A:
undetectable
5kb6A-3oq0A:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oq4 DBF4

(Saccharomyces
cerevisiae)
PF08630
(Dfp1_Him1_M)
5 GLY A 154
ILE A 174
ALA A 160
GLY A 159
ILE A 126
None
0.90A 5kb6A-3oq4A:
undetectable
5kb6A-3oq4A:
16.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3otx ADENOSINE KINASE,
PUTATIVE


(Trypanosoma
brucei)
PF00294
(PfkB)
9 THR A 264
THR A 270
VAL A 283
GLN A 288
ALA A 297
GLY A 298
HIS A 323
ALA A 326
ILE A 330
AP5  A 346 (-3.6A)
AP5  A 346 (-4.5A)
AP5  A 346 (-4.1A)
AP5  A 346 (-3.1A)
AP5  A 346 (-3.4A)
AP5  A 346 (-3.2A)
AP5  A 346 (-3.8A)
AP5  A 346 (-3.0A)
AP5  A 346 (-4.9A)
0.51A 5kb6A-3otxA:
44.6
5kb6A-3otxA:
40.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qe3 SORBITOL
DEHYDROGENASE


(Ovis aries)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
6 THR A 245
ILE A 222
ALA A 257
GLY A 258
ALA A 231
ILE A 230
None
1.13A 5kb6A-3qe3A:
5.4
5kb6A-3qe3A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qe3 SORBITOL
DEHYDROGENASE


(Ovis aries)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
6 THR A 245
VAL A 199
ILE A 222
ALA A 257
GLY A 258
ILE A 230
None
1.16A 5kb6A-3qe3A:
5.4
5kb6A-3qe3A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ry7 RIBOKINASE

(Staphylococcus
aureus)
PF00294
(PfkB)
5 THR A 222
GLY A 224
THR A 228
ALA A 252
GLY A 253
None
0.70A 5kb6A-3ry7A:
27.6
5kb6A-3ry7A:
26.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tgw V-TYPE ATP SYNTHASE
BETA CHAIN


(Methanosarcina
mazei)
PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N)
5 GLY A  35
THR A  38
ILE A 110
ALA A 114
ALA A 113
GOL  A 463 (-3.5A)
None
None
GOL  A 463 (-4.2A)
GOL  A 465 ( 3.5A)
0.85A 5kb6A-3tgwA:
undetectable
5kb6A-3tgwA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqd 3-DEOXY-MANNO-OCTULO
SONATE
CYTIDYLYLTRANSFERASE


(Coxiella
burnetii)
PF02348
(CTP_transf_3)
5 ILE A   7
ALA A  63
GLY A  62
ALA A  58
ILE A  47
None
0.82A 5kb6A-3tqdA:
undetectable
5kb6A-3tqdA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ubo ADENOSINE KINASE

(Sinorhizobium
meliloti)
PF00294
(PfkB)
5 THR A 245
ALA A 276
GLY A 277
ALA A 305
ILE A 309
ADP  A 354 (-3.3A)
ADP  A 354 (-3.4A)
ADP  A 354 (-3.4A)
ADP  A 354 (-2.7A)
None
0.59A 5kb6A-3uboA:
35.5
5kb6A-3uboA:
26.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vas PUTATIVE ADENOSINE
KINASE


(Schistosoma
mansoni)
PF00294
(PfkB)
7 THR A 265
GLY A 267
ILE A 294
ALA A 300
GLY A 301
ALA A 329
ILE A 333
None
0.65A 5kb6A-3vasA:
45.2
5kb6A-3vasA:
37.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vas PUTATIVE ADENOSINE
KINASE


(Schistosoma
mansoni)
PF00294
(PfkB)
7 THR A 265
GLY A 267
VAL A 286
ALA A 300
GLY A 301
ALA A 329
ILE A 333
None
0.39A 5kb6A-3vasA:
45.2
5kb6A-3vasA:
37.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e3a SUGAR KINASE PROTEIN

(Rhizobium etli)
PF00294
(PfkB)
5 THR A 243
ALA A 274
GLY A 275
ALA A 303
ILE A 307
None
0.36A 5kb6A-4e3aA:
36.7
5kb6A-4e3aA:
27.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e69 2-DEHYDRO-3-DEOXYGLU
CONOKINASE


(Oceanicola
granulosus)
PF00294
(PfkB)
5 GLY A 225
VAL A 242
ALA A 254
GLY A 255
ALA A 283
None
0.31A 5kb6A-4e69A:
14.7
5kb6A-4e69A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fr2 1,3-PROPANEDIOL
DEHYDROGENASE


(Oenococcus oeni)
PF00465
(Fe-ADH)
5 GLY A 145
ILE A 227
ALA A 254
GLY A 255
HIS A 267
None
None
None
None
NI  A 501 (-3.4A)
0.88A 5kb6A-4fr2A:
3.6
5kb6A-4fr2A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gek TRNA
(CMO5U34)-METHYLTRAN
SFERASE


(Escherichia
coli)
PF13649
(Methyltransf_25)
5 THR A 134
ALA A  69
GLY A  68
ALA A  70
ILE A  43
GEK  A 302 ( 3.8A)
SO4  A 301 (-3.7A)
None
GEK  A 302 ( 4.1A)
None
0.86A 5kb6A-4gekA:
3.9
5kb6A-4gekA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iwn TRNA
(CMO5U34)-METHYLTRAN
SFERASE


(Escherichia
coli)
PF13649
(Methyltransf_25)
5 THR A 134
ALA A  69
GLY A  68
ALA A  70
ILE A  43
GEK  A 301 ( 3.8A)
GEK  A 301 (-3.6A)
None
GEK  A 301 ( 4.1A)
None
0.90A 5kb6A-4iwnA:
3.8
5kb6A-4iwnA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jhy HYPOTHETICAL PROTEIN

(Parabacteroides
distasonis)
PF14730
(DUF4468)
5 THR A  47
ILE A 106
ALA A 178
ALA A  55
ILE A  56
None
0.89A 5kb6A-4jhyA:
undetectable
5kb6A-4jhyA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jrm 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2


(Vibrio cholerae)
no annotation 5 GLY D 172
ILE D 178
ALA D 188
GLY D 189
ALA D 104
None
0.89A 5kb6A-4jrmD:
undetectable
5kb6A-4jrmD:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kys THIAMINE
PYRIDINYLASE I


(Clostridium
botulinum)
PF01547
(SBP_bac_1)
5 ILE A 267
ALA A 237
GLY A 238
ALA A 242
ILE A 187
None
0.89A 5kb6A-4kysA:
undetectable
5kb6A-4kysA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lb0 UNCHARACTERIZED
PROTEIN


(Agrobacterium
vitis)
PF05544
(Pro_racemase)
5 THR A 257
GLY A 173
VAL A 147
ALA A  91
ILE A 222
ACT  A 401 (-2.8A)
None
None
None
None
0.86A 5kb6A-4lb0A:
undetectable
5kb6A-4lb0A:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lmp ALANINE
DEHYDROGENASE


(Mycobacterium
tuberculosis)
PF01262
(AlaDh_PNT_C)
PF05222
(AlaDh_PNT_N)
5 GLY A  22
ILE A   5
ALA A  55
GLY A  54
ILE A  35
None
0.73A 5kb6A-4lmpA:
5.3
5kb6A-4lmpA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ls5 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2


(Bacillus
subtilis)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
5 GLY A 188
THR A 165
ALA A  77
ALA A 142
ILE A 146
None
0.72A 5kb6A-4ls5A:
undetectable
5kb6A-4ls5A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ls5 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2


(Bacillus
subtilis)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
5 GLY A 231
ALA A 343
GLY A 342
ALA A 344
ILE A 347
None
0.85A 5kb6A-4ls5A:
undetectable
5kb6A-4ls5A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4my0 GCN5-RELATED
N-ACETYLTRANSFERASE


(Kribbella
flavida)
PF13527
(Acetyltransf_9)
PF13530
(SCP2_2)
6 THR A 352
GLY A 134
GLN A  70
ILE A 115
ALA A 346
GLY A 344
None
1.46A 5kb6A-4my0A:
undetectable
5kb6A-4my0A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mzy NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE


(Enterococcus
faecalis)
PF04095
(NAPRTase)
5 GLY A  55
ILE A 436
ALA A 177
ALA A 142
ILE A 180
None
GOL  A 504 ( 4.3A)
None
None
None
0.81A 5kb6A-4mzyA:
2.9
5kb6A-4mzyA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pvv ADENOSINE KINASE

(Mycobacterium
tuberculosis)
PF00294
(PfkB)
5 THR A 223
GLY A 225
VAL A 243
GLY A 256
ALA A 284
None
0.67A 5kb6A-4pvvA:
26.2
5kb6A-4pvvA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q2h PROLINE RACEMASE
PROTEIN


(Agrobacterium
tumefaciens)
PF05544
(Pro_racemase)
5 THR A 257
GLY A 173
VAL A 147
ALA A  91
ILE A 222
BCT  A 401 (-2.8A)
None
None
None
None
0.88A 5kb6A-4q2hA:
undetectable
5kb6A-4q2hA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rk6 GLUCOSE-RESISTANCE
AMYLASE REGULATOR


(Weissella
paramesenteroides)
PF13377
(Peripla_BP_3)
5 GLY A 225
VAL A 229
ALA A 245
ALA A 243
ILE A 271
None
0.83A 5kb6A-4rk6A:
6.0
5kb6A-4rk6A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wjm RIBOKINASE:CARBOHYDR
ATE KINASE, PFKB


(Brucella
abortus)
PF00294
(PfkB)
5 THR A 217
GLY A 219
ALA A 247
GLY A 248
ALA A 289
ANP  A 401 (-3.5A)
ANP  A 401 (-3.6A)
ANP  A 401 (-3.3A)
ANP  A 401 (-3.4A)
ANP  A 401 (-3.5A)
0.28A 5kb6A-4wjmA:
28.8
5kb6A-4wjmA:
25.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x8f RIBOKINASE

(Vibrio cholerae)
PF00294
(PfkB)
6 THR A 220
GLY A 222
ALA A 250
GLY A 251
HIS A 276
ALA A 279
None
0.64A 5kb6A-4x8fA:
29.2
5kb6A-4x8fA:
25.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yji ARYL ACYLAMIDASE

(bacterium
CSBL00001)
PF01425
(Amidase)
6 THR A 142
GLY A 162
ALA A 167
GLY A 166
ALA A 168
ILE A 227
None
1.14A 5kb6A-4yjiA:
undetectable
5kb6A-4yjiA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yji ARYL ACYLAMIDASE

(bacterium
CSBL00001)
PF01425
(Amidase)
6 THR A 142
GLY A 162
ILE A 188
ALA A 167
GLY A 166
ALA A 168
None
1.26A 5kb6A-4yjiA:
undetectable
5kb6A-4yjiA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c41 RIBOKINASE

(Homo sapiens)
PF00294
(PfkB)
5 THR A 235
GLY A 237
ALA A 267
GLY A 268
ALA A 298
ACP  A 401 (-3.2A)
ACP  A 401 (-3.3A)
ACP  A 401 (-3.5A)
ACP  A 401 (-3.4A)
ACP  A 401 (-3.3A)
0.36A 5kb6A-5c41A:
31.5
5kb6A-5c41A:
28.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cvo WD REPEAT-CONTAINING
PROTEIN 48


(Homo sapiens)
PF00400
(WD40)
5 GLY A 186
THR A 188
ALA A 135
GLY A 136
ILE A 141
None
0.91A 5kb6A-5cvoA:
undetectable
5kb6A-5cvoA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dx5 METHIONINE
GAMMA-LYASE


(Clostridium
sporogenes)
PF01053
(Cys_Met_Meta_PP)
6 THR A 244
GLY A 239
ILE A 232
ALA A  91
GLY A  90
ALA A  85
None
1.10A 5kb6A-5dx5A:
undetectable
5kb6A-5dx5A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h6s AMIDASE

(Microbacterium
sp. HM58-2)
PF01425
(Amidase)
6 GLY A 154
THR A 151
ILE A 180
GLY A 158
ALA A 160
ILE A 223
None
1.45A 5kb6A-5h6sA:
undetectable
5kb6A-5h6sA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jy9 PUTATIVE SALICYLATE
SYNTHETASE


(Yersinia
enterocolitica)
PF00425
(Chorismate_bind)
6 THR A 258
VAL A 319
ILE A 428
ALA A 404
GLY A 405
HIS A 321
ACT  A 503 (-3.7A)
None
None
ACT  A 502 (-3.8A)
ACT  A 502 (-3.4A)
ACT  A 503 ( 4.1A)
1.44A 5kb6A-5jy9A:
undetectable
5kb6A-5jy9A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m5j THIOREDOXIN
REDUCTASE


(Giardia
intestinalis)
PF07992
(Pyr_redox_2)
5 THR A  32
GLY A  10
ALA A  21
GLY A  22
ALA A 303
None
0.79A 5kb6A-5m5jA:
3.6
5kb6A-5m5jA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uju NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE


(Burkholderia
multivorans)
PF00171
(Aldedh)
6 THR A 321
THR A 358
ILE A 349
ALA A 328
ALA A 371
ILE A 372
None
1.31A 5kb6A-5ujuA:
undetectable
5kb6A-5ujuA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xbf HARMONIN

(Homo sapiens)
PF00595
(PDZ)
5 ILE B 533
ALA B 489
GLY B 488
ALA B 490
ILE B 458
None
0.84A 5kb6A-5xbfB:
undetectable
5kb6A-5xbfB:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y9p -

(-)
no annotation 6 GLN A 180
ILE A 169
ALA A 156
GLY A 133
ALA A  93
ILE A  77
None
1.47A 5kb6A-5y9pA:
undetectable
5kb6A-5y9pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6h7x -

(-)
no annotation 5 GLY A  89
VAL A 295
ILE A  75
ALA A  56
GLY A  57
EDO  A1008 ( 4.2A)
None
None
None
None
0.90A 5kb6A-6h7xA:
undetectable
5kb6A-6h7xA:
undetectable