SIMILAR PATTERNS OF AMINO ACIDS FOR 5K9D_A_CE9A402

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eys PHOTOSYNTHETIC
REACTION CENTER

(Thermochromatium
tepidum) 		PF00124
(Photo_RC) 		5 ALA L 180
HIS L 181
LEU L 183
ALA L 184
PHE L 187
 None
BCL  L 602 (-4.0A)
BGL  L 701 (-3.3A)
BCL  L 602 (-3.5A)
None
 0.67A 5k9dA-1eysL:
0.0		 5k9dA-1eysL:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fch PEROXISOMAL
TARGETING SIGNAL 1
RECEPTOR

(Homo sapiens) 		PF13374
(TPR_10)
PF13432
(TPR_16) 		5 ALA A 373
LEU A 372
ALA A 371
THR A 340
LEU A 486
 None
 1.18A 5k9dA-1fchA:
0.0		 5k9dA-1fchA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ltm 36 KDA SOLUBLE LYTIC
TRANSGLYCOSYLASE

(Escherichia
coli) 		PF13406
(SLT_2) 		5 ALA A 220
ALA A 218
PHE A 217
PHE A 192
TYR A 191
 BCN  A 401 ( 3.9A)
EDO  A 402 ( 3.8A)
None
None
EDO  A 402 (-4.9A)
 1.14A 5k9dA-1ltmA:
undetectable		 5k9dA-1ltmA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ny5 TRANSCRIPTIONAL
REGULATOR (NTRC
FAMILY)

(Aquifex
aeolicus) 		PF00072
(Response_reg)
PF00158
(Sigma54_activat) 		5 LEU A 320
ALA A 321
PHE A 324
PHE A 339
LEU A 380
 None
 1.05A 5k9dA-1ny5A:
1.8		 5k9dA-1ny5A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o9j ALDEHYDE
DEHYDROGENASE,
CYTOSOLIC 1

(Elephantulus
edwardii) 		PF00171
(Aldedh) 		5 ALA A 281
ALA A 286
PHE A 289
PHE A 318
LEU A 308
 None
 1.19A 5k9dA-1o9jA:
0.6		 5k9dA-1o9jA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qvr CLPB PROTEIN

(Thermus
thermophilus) 		PF00004
(AAA)
PF02861
(Clp_N)
PF07724
(AAA_2)
PF10431
(ClpB_D2-small) 		5 ALA A 605
LEU A 608
ALA A 609
PHE A 613
THR A 615
 None
 1.05A 5k9dA-1qvrA:
1.2		 5k9dA-1qvrA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r0l 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE

(Zymomonas
mobilis) 		PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C) 		5 ALA A 123
LEU A 122
ALA A 121
THR A 119
THR A  20
 None
 1.14A 5k9dA-1r0lA:
1.3		 5k9dA-1r0lA:
21.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1uuo DIHYDROOROTATE
DEHYDROGENASE

(Rattus rattus) 		PF01180
(DHO_dh) 		10 MET A  43
ALA A  55
HIS A  56
LEU A  58
ALA A  59
THR A  63
PHE A  98
TYR A 356
LEU A 359
PRO A 364
 BRF  A1397 (-4.1A)
BRF  A1397 (-3.2A)
BRF  A1397 (-4.0A)
None
BRF  A1397 (-3.5A)
BRF  A1397 ( 4.7A)
None
FMN  A1398 ( 4.2A)
None
BRF  A1397 (-4.6A)
 0.64A 5k9dA-1uuoA:
60.9		 5k9dA-1uuoA:
87.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vg0 RAB PROTEINS
GERANYLGERANYLTRANSF
ERASE COMPONENT A 1

(Rattus
norvegicus) 		PF00996
(GDI) 		5 ALA A 339
PHE A 358
THR A 355
PHE A 317
LEU A 321
 None
 1.09A 5k9dA-1vg0A:
0.0		 5k9dA-1vg0A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xbz 3-KETO-L-GULONATE
6-PHOSPHATE
DECARBOXYLASE

(Escherichia
coli) 		PF00215
(OMPdecase) 		5 ALA A 102
LEU A  99
ALA A  98
THR A  94
LEU A  72
 None
 1.12A 5k9dA-1xbzA:
8.2		 5k9dA-1xbzA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zk7 MERCURIC REDUCTASE

(Pseudomonas
aeruginosa) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 ALA A 188
LEU A 191
ALA A 192
PHE A 195
PHE A 226
 None
 1.03A 5k9dA-1zk7A:
undetectable		 5k9dA-1zk7A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a1x PHYTANOYL-COA
DIOXYGENASE

(Homo sapiens) 		PF05721
(PhyH) 		5 MET A 250
LEU A  67
PHE A  66
TYR A 133
THR A 194
 None
 1.19A 5k9dA-2a1xA:
undetectable		 5k9dA-2a1xA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2adv GLUTARYL 7-
AMINOCEPHALOSPORANIC
ACID ACYLASE
GLUTARYL 7-
AMINOCEPHALOSPORANIC
ACID ACYLASE

(Pseudomonas sp.
SY-77-1;
Pseudomonas sp.
SY-77-1) 		PF01804
(Penicil_amidase)
PF01804
(Penicil_amidase) 		5 ALA B  16
LEU B  17
ALA B   5
THR C 187
PRO C 235
 None
 1.19A 5k9dA-2advB:
undetectable		 5k9dA-2advB:
7.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c0l PEROXISOMAL
TARGETING SIGNAL 1
RECEPTOR

(Homo sapiens) 		PF00515
(TPR_1)
PF13432
(TPR_16) 		5 ALA A 410
LEU A 409
ALA A 408
THR A 377
LEU A 523
 None
 1.21A 5k9dA-2c0lA:
undetectable		 5k9dA-2c0lA:
25.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hcs RNA-DIRECTED RNA
POLYMERASE (NS5)

(West Nile virus) 		PF00972
(Flavi_NS5) 		5 ALA A 388
LEU A 387
PHE A 615
PHE A 493
LEU A 559
 None
 1.18A 5k9dA-2hcsA:
undetectable		 5k9dA-2hcsA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iml HYPOTHETICAL PROTEIN

(Archaeoglobus
fulgidus) 		PF04289
(DUF447) 		5 MET A 185
ALA A 143
HIS A 142
LEU A 140
ALA A 139
 None
None
None
FMN  A 200 (-3.9A)
None
 1.04A 5k9dA-2imlA:
undetectable		 5k9dA-2imlA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o0h DNA PACKAGING
PROTEIN GP17

(Escherichia
virus T4) 		PF03237
(Terminase_6) 		5 ALA A 171
LEU A 174
ALA A 175
PHE A 120
LEU A 210
 None
 1.02A 5k9dA-2o0hA:
undetectable		 5k9dA-2o0hA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oew PROGRAMMED CELL
DEATH 6-INTERACTING
PROTEIN

(Homo sapiens) 		PF03097
(BRO1) 		5 ALA A 131
LEU A 130
ALA A 129
PHE A 125
LEU A 187
 None
 1.20A 5k9dA-2oewA:
undetectable		 5k9dA-2oewA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2owo DNA LIGASE

(Escherichia
coli) 		PF01653
(DNA_ligase_aden)
PF03119
(DNA_ligase_ZBD)
PF03120
(DNA_ligase_OB)
PF12826
(HHH_2)
PF14520
(HHH_5) 		5 ALA A 525
LEU A 528
ALA A 529
PHE A 532
THR A 507
 None
None
None
None
SO4  A 674 ( 4.1A)
 1.13A 5k9dA-2owoA:
undetectable		 5k9dA-2owoA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qxy RESPONSE REGULATOR

(Thermotoga
maritima) 		PF00072
(Response_reg) 		5 LEU A  18
ALA A  19
PHE A  17
PHE A 106
LEU A 111
 None
 1.19A 5k9dA-2qxyA:
2.9		 5k9dA-2qxyA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r6i UNCHARACTERIZED
PROTEIN ATU1473

(Agrobacterium
fabrum) 		PF07542
(ATP12) 		5 ALA A 207
LEU A 204
ALA A 205
TYR A 183
LEU A 180
 None
 1.15A 5k9dA-2r6iA:
undetectable		 5k9dA-2r6iA:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rfo NUCLEOPORIN NIC96

(Saccharomyces
cerevisiae) 		PF04097
(Nic96) 		5 ALA A 503
HIS A 505
LEU A 506
TYR A 556
LEU A 538
 None
 1.11A 5k9dA-2rfoA:
undetectable		 5k9dA-2rfoA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rhq PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN

(Staphylococcus
haemolyticus) 		PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5) 		5 ALA B 322
HIS B 272
LEU B 321
ALA B 320
PHE B 274
 None
 1.21A 5k9dA-2rhqB:
undetectable		 5k9dA-2rhqB:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vou 2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE

(Paenarthrobacter
nicotinovorans) 		PF00070
(Pyr_redox) 		5 ALA A 326
LEU A 329
ALA A 330
PHE A 333
THR A 334
 None
 0.66A 5k9dA-2vouA:
undetectable		 5k9dA-2vouA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vyf REPLICATIVE DNA
HELICASE

(Geobacillus
kaustophilus) 		PF00772
(DnaB)
PF03796
(DnaB_C) 		5 ALA A  30
LEU A  33
ALA A  34
PHE A  52
LEU A  21
 None
 1.09A 5k9dA-2vyfA:
undetectable		 5k9dA-2vyfA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xqy ENVELOPE
GLYCOPROTEIN H

(Suid
alphaherpesvirus
1) 		PF02489
(Herpes_glycop_H)
PF17488
(Herpes_glycoH_C) 		5 ALA A 252
HIS A 251
LEU A 255
ALA A 254
LEU A 273
 None
 1.21A 5k9dA-2xqyA:
undetectable		 5k9dA-2xqyA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b33 SENSOR PROTEIN

(Vibrio
parahaemolyticus) 		PF00989
(PAS) 		5 MET A 108
ALA A  32
LEU A  35
TYR A  28
THR A  17
 None
 1.04A 5k9dA-3b33A:
undetectable		 5k9dA-3b33A:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bfj 1,3-PROPANEDIOL
OXIDOREDUCTASE

(Klebsiella
pneumoniae) 		PF00465
(Fe-ADH) 		5 ALA A 203
HIS A 202
LEU A 200
ALA A 199
THR A 195
 None
FE2  A1388 (-3.4A)
None
None
None
 1.08A 5k9dA-3bfjA:
undetectable		 5k9dA-3bfjA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bjr PUTATIVE
CARBOXYLESTERASE

(Lactobacillus
plantarum) 		PF07859
(Abhydrolase_3) 		5 ALA A  50
LEU A  53
ALA A  54
PHE A  57
THR A  16
 None
 0.62A 5k9dA-3bjrA:
undetectable		 5k9dA-3bjrA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c0k UPF0064 PROTEIN YCCW

(Escherichia
coli) 		PF10672
(Methyltrans_SAM) 		5 ALA A 325
LEU A 328
PHE A 294
LEU A 336
THR A 337
 None
 0.96A 5k9dA-3c0kA:
undetectable		 5k9dA-3c0kA:
24.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ci6 PHOSPHOENOLPYRUVATE-
PROTEIN
PHOSPHOTRANSFERASE

(Acinetobacter
sp. ADP1) 		PF01590
(GAF) 		5 ALA A  34
ALA A  36
THR A   8
PHE A 146
LEU A 150
 None
P4G  A 169 ( 4.3A)
P4G  A 169 (-3.6A)
P4G  A 169 ( 4.2A)
None
 1.18A 5k9dA-3ci6A:
undetectable		 5k9dA-3ci6A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cjd TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY

(Jannaschia sp.
CCS1) 		PF00440
(TetR_N)
PF13305
(WHG) 		5 ALA A 129
HIS A 128
LEU A 133
ALA A 131
PHE A 134
 None
None
STE  A 203 (-4.0A)
None
None
 1.11A 5k9dA-3cjdA:
undetectable		 5k9dA-3cjdA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cjy PUTATIVE
THIOESTERASE

(Novosphingobium
aromaticivorans) 		PF13622
(4HBT_3) 		5 ALA A  43
LEU A  44
ALA A  41
PHE A   5
LEU A  24
 None
 1.16A 5k9dA-3cjyA:
undetectable		 5k9dA-3cjyA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cs3 SUGAR-BINDING
TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY

(Enterococcus
faecalis) 		PF13377
(Peripla_BP_3) 		5 LEU A  66
ALA A  67
THR A 118
THR A 210
PRO A 178
 None
 1.18A 5k9dA-3cs3A:
undetectable		 5k9dA-3cs3A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e0u GLUTATHIONE
PEROXIDASE

(Trypanosoma
cruzi) 		PF00255
(GSHPx) 		5 LEU A  73
ALA A  74
PHE A  75
PHE A  99
TYR A  55
 None
None
NH4  A   1 (-4.7A)
None
None
 1.21A 5k9dA-3e0uA:
undetectable		 5k9dA-3e0uA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e53 FATTY-ACID-COA
LIGASE FADD28

(Mycobacterium
tuberculosis) 		PF00501
(AMP-binding) 		5 ALA A 272
LEU A 275
ALA A 276
THR A 280
PHE A 315
 None
 0.83A 5k9dA-3e53A:
undetectable		 5k9dA-3e53A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3efz 14-3-3 PROTEIN

(Cryptosporidium
parvum) 		PF00244
(14-3-3) 		5 ALA A 178
ALA A 142
PHE A 143
PHE A 185
LEU A 186
 None
 1.14A 5k9dA-3efzA:
undetectable		 5k9dA-3efzA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egw RESPIRATORY NITRATE
REDUCTASE 1 ALPHA
CHAIN

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF14710
(Nitr_red_alph_N) 		5 ALA A 308
LEU A 307
ALA A 304
THR A 301
PRO A 297
 None
 1.17A 5k9dA-3egwA:
undetectable		 5k9dA-3egwA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hum PENICILLIN-BINDING
PROTEIN 4

(Staphylococcus
aureus) 		PF00768
(Peptidase_S11)
PF09211
(DUF1958) 		5 ALA A 143
LEU A 147
PHE A 158
THR A 155
LEU A 187
 None
 1.17A 5k9dA-3humA:
undetectable		 5k9dA-3humA:
23.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3i6r DIHYDROOROTATE
DEHYDROGENASE
HOMOLOG,
MITOCHONDRIAL

(Plasmodium
falciparum) 		PF01180
(DHO_dh) 		5 HIS A 185
LEU A 187
PHE A 227
TYR A 528
LEU A 531
 J5Z  A1001 (-4.0A)
None
J5Z  A1001 (-4.4A)
FMN  A1002 (-3.9A)
J5Z  A1001 (-4.4A)
 1.08A 5k9dA-3i6rA:
52.9		 5k9dA-3i6rA:
37.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ipi GERANYLTRANSTRANSFER
ASE

(Methanosarcina
mazei) 		PF00348
(polyprenyl_synt) 		5 ALA A  76
LEU A  77
ALA A  78
PHE A 128
PHE A 140
 None
 1.10A 5k9dA-3ipiA:
undetectable		 5k9dA-3ipiA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k17 LIN0012 PROTEIN

(Listeria
innocua) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		5 ALA A 326
THR A  35
PHE A 351
THR A 216
PRO A 213
 None
 1.02A 5k9dA-3k17A:
undetectable		 5k9dA-3k17A:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l5k HALOACID
DEHALOGENASE-LIKE
HYDROLASE
DOMAIN-CONTAINING
PROTEIN 1A

(Homo sapiens) 		PF13419
(HAD_2) 		5 ALA A 112
LEU A 111
ALA A 110
PHE A 134
PHE A 162
 None
 1.12A 5k9dA-3l5kA:
undetectable		 5k9dA-3l5kA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m0e TRANSCRIPTIONAL
REGULATOR (NTRC
FAMILY)

(Aquifex
aeolicus) 		PF00158
(Sigma54_activat) 		5 LEU A 320
ALA A 321
PHE A 324
PHE A 339
LEU A 380
 None
 1.02A 5k9dA-3m0eA:
undetectable		 5k9dA-3m0eA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1c ENVELOPE
GLYCOPROTEIN H

(Human
alphaherpesvirus
2) 		PF02489
(Herpes_glycop_H)
PF17488
(Herpes_glycoH_C) 		5 MET A 514
ALA A 471
HIS A 470
LEU A 472
ALA A 469
 None
 1.09A 5k9dA-3m1cA:
undetectable		 5k9dA-3m1cA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nra ASPARTATE
AMINOTRANSFERASE

(Rhodobacter
sphaeroides) 		PF00155
(Aminotran_1_2) 		5 ALA A 113
LEU A 116
ALA A 117
THR A 121
THR A 246
 None
 0.93A 5k9dA-3nraA:
undetectable		 5k9dA-3nraA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qe7 URACIL PERMEASE

(Escherichia
coli) 		PF00860
(Xan_ur_permease) 		5 ALA A  44
LEU A  47
TYR A 219
LEU A 218
THR A 217
 None
 1.11A 5k9dA-3qe7A:
undetectable		 5k9dA-3qe7A:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rha PUTRESCINE OXIDASE

(Paenarthrobacter
aurescens) 		PF01593
(Amino_oxidase) 		5 MET A 175
ALA A 192
HIS A 200
ALA A 195
PHE A 206
 None
 1.16A 5k9dA-3rhaA:
undetectable		 5k9dA-3rhaA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s29 SUCROSE SYNTHASE 1

(Arabidopsis
thaliana) 		PF00534
(Glycos_transf_1)
PF00862
(Sucrose_synth) 		5 ALA A 721
LEU A 724
ALA A 725
PHE A 728
THR A 729
 None
 0.41A 5k9dA-3s29A:
undetectable		 5k9dA-3s29A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s29 SUCROSE SYNTHASE 1

(Arabidopsis
thaliana) 		PF00534
(Glycos_transf_1)
PF00862
(Sucrose_synth) 		5 LEU A 724
ALA A 725
PHE A 728
THR A 729
THR A 598
 None
 0.97A 5k9dA-3s29A:
undetectable		 5k9dA-3s29A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wwt PROTEIN C'

(Murine
respirovirus) 		PF01692
(Paramyxo_C) 		5 ALA B 194
LEU B 197
ALA B 198
PHE B 170
THR B 158
 None
 0.91A 5k9dA-3wwtB:
undetectable		 5k9dA-3wwtB:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bub UDP-N-ACETYLMURAMOYL
-L-ALANYL-D-GLUTAMAT
E--LD-LYSINE LIGASE

(Thermotoga
maritima) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		5 ALA A 393
LEU A 392
ALA A 389
PHE A 371
LEU A 398
 None
 1.10A 5k9dA-4bubA:
undetectable		 5k9dA-4bubA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dnv AT5G63860/MGI19_6

(Arabidopsis
thaliana) 		PF00415
(RCC1) 		5 LEU A 291
ALA A 290
THR A 288
LEU A 270
PRO A 319
 None
 1.15A 5k9dA-4dnvA:
undetectable		 5k9dA-4dnvA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dol AT1G53520

(Arabidopsis
thaliana) 		PF02431
(Chalcone) 		5 ALA A 120
LEU A 117
ALA A 116
PHE A 113
THR A 112
 PLM  A 301 ( 3.7A)
PLM  A 301 ( 4.7A)
PLM  A 301 (-3.5A)
PLM  A 301 (-4.8A)
None
 0.97A 5k9dA-4dolA:
undetectable		 5k9dA-4dolA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4egv ACETYL-COA
ACETYLTRANSFERASE

(Mycolicibacterium
smegmatis) 		no annotation 5 ALA A 203
LEU A 207
ALA A 205
PHE A 208
PRO A 247
 None
 1.13A 5k9dA-4egvA:
undetectable		 5k9dA-4egvA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f6t MOLYBDENUM STORAGE
PROTEIN SUBUNIT
ALPHA

(Azotobacter
vinelandii) 		PF00696
(AA_kinase) 		5 ALA A 174
LEU A 177
ALA A 178
PHE A 181
THR A 187
 None
 1.13A 5k9dA-4f6tA:
undetectable		 5k9dA-4f6tA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4glx DNA LIGASE

(Escherichia
coli) 		PF01653
(DNA_ligase_aden)
PF03119
(DNA_ligase_ZBD)
PF03120
(DNA_ligase_OB)
PF12826
(HHH_2)
PF14520
(HHH_5) 		5 ALA A 525
LEU A 528
ALA A 529
PHE A 532
THR A 507
 None
None
None
None
SO4  A 602 ( 3.9A)
 1.15A 5k9dA-4glxA:
undetectable		 5k9dA-4glxA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h8a UREIDOGLYCOLATE
DEHYDROGENASE

(Escherichia
coli) 		PF02615
(Ldh_2) 		5 ALA A 160
LEU A 159
LEU A 171
THR A 172
PRO A 305
 None
None
None
None
NAI  A 401 ( 4.7A)
 1.19A 5k9dA-4h8aA:
undetectable		 5k9dA-4h8aA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hts SEC-INDEPENDENT
PROTEIN TRANSLOCASE
PROTEIN TATC

(Aquifex
aeolicus) 		PF00902
(TatC) 		5 ALA A 126
PHE A 129
THR A 208
PHE A 152
LEU A 156
 None
 1.06A 5k9dA-4htsA:
undetectable		 5k9dA-4htsA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i3u ALDEHYDE
DEHYDROGENASE (NAD+)

(Sinorhizobium
meliloti) 		PF00171
(Aldedh) 		5 ALA A  79
LEU A  80
ALA A  77
PHE A 113
THR A 114
 None
 1.16A 5k9dA-4i3uA:
undetectable		 5k9dA-4i3uA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mca GLYCEROL
DEHYDROGENASE

(Serratia
plymuthica) 		PF00465
(Fe-ADH) 		5 MET A 339
ALA A 255
HIS A 254
ALA A 253
THR A 279
 None
None
ZN  A1000 (-3.1A)
None
None
 1.06A 5k9dA-4mcaA:
undetectable		 5k9dA-4mcaA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n4r LPS-ASSEMBLY PROTEIN
LPTD
LPS-ASSEMBLY
LIPOPROTEIN LPTE

(Salmonella
enterica;
Salmonella
enterica) 		PF04453
(OstA_C)
PF04390
(LptE) 		5 ALA A 638
ALA A 661
PHE B 127
LEU A 670
THR A 669
 None
 1.21A 5k9dA-4n4rA:
undetectable		 5k9dA-4n4rA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n7w TRANSPORTER,
SODIUM/BILE ACID
SYMPORTER FAMILY

(Yersinia
frederiksenii) 		PF01758
(SBF) 		5 ALA A  79
LEU A  82
ALA A  83
PHE A  86
PRO A  89
 None
 1.15A 5k9dA-4n7wA:
undetectable		 5k9dA-4n7wA:
26.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q22 GLYCOSIDE HYDROLASE
FAMILY 18

(Serratia
proteamaculans) 		PF00704
(Glyco_hydro_18) 		5 ALA A 406
HIS A 407
LEU A 409
ALA A 410
THR A  49
 None
 0.70A 5k9dA-4q22A:
5.0		 5k9dA-4q22A:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qp0 ENDO-BETA-MANNANASE

(Rhizomucor
miehei) 		PF00150
(Cellulase) 		5 ALA A 279
HIS A 278
ALA A 281
PHE A 223
TYR A 233
 None
 1.17A 5k9dA-4qp0A:
7.8		 5k9dA-4qp0A:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tq5 PRENYLTRANSFERASE

(Archaeoglobus
fulgidus) 		PF01040
(UbiA) 		5 MET A  61
ALA A 159
LEU A 162
ALA A 163
LEU A  30
 None
 1.08A 5k9dA-4tq5A:
undetectable		 5k9dA-4tq5A:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4upi SULFATASE FAMILY
PROTEIN

(Ruegeria
pomeroyi) 		PF00884
(Sulfatase) 		5 MET A  94
ALA A 226
HIS A 227
LEU A   8
LEU A  85
 None
 1.19A 5k9dA-4upiA:
undetectable		 5k9dA-4upiA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wky BETA-KETOACYL
SYNTHASE

(Streptomyces
albus) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 ALA A 439
HIS A 198
ALA A 437
PHE A 430
THR A 435
 None
 1.11A 5k9dA-4wkyA:
undetectable		 5k9dA-4wkyA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wv3 ANTHRANILATE-COA
LIGASE

(Stigmatella
aurantiaca) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 ALA A 216
ALA A 214
PHE A 213
THR A 212
THR A 224
 None
 1.20A 5k9dA-4wv3A:
undetectable		 5k9dA-4wv3A:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zv9 UNCHARACTERIZED
PROTEIN

(Escherichia
coli) 		PF01738
(DLH) 		6 ALA A 278
HIS A 267
LEU A 281
ALA A 282
THR A 286
PHE A 208
 None
 1.42A 5k9dA-4zv9A:
undetectable		 5k9dA-4zv9A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zv9 UNCHARACTERIZED
PROTEIN

(Escherichia
coli) 		PF01738
(DLH) 		6 ALA A 278
LEU A 281
ALA A 282
THR A 286
PHE A 208
TYR A 209
 None
None
None
None
None
CME  A 186 ( 4.8A)
 1.48A 5k9dA-4zv9A:
undetectable		 5k9dA-4zv9A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a89 RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBF

(Corynebacterium
ammoniagenes) 		PF01687
(Flavokinase) 		5 MET A 242
LEU A 272
ALA A 250
PHE A 270
THR A 230
 None
None
None
ADP  A 501 ( 4.9A)
None
 1.21A 5k9dA-5a89A:
undetectable		 5k9dA-5a89A:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5chh ARAC FAMILY
TRANSCRIPTIONAL
REGULATOR

(Pseudomonas
aeruginosa) 		PF12625
(Arabinose_bd)
PF12833
(HTH_18) 		5 ALA A 136
LEU A 139
ALA A 140
PHE A 176
TYR A 172
 None
 1.19A 5k9dA-5chhA:
undetectable		 5k9dA-5chhA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cju ISOBUTYRYL-COA
MUTASE FUSED

(Cupriavidus
metallidurans) 		PF01642
(MM_CoA_mutase)
PF02310
(B12-binding)
PF03308
(ArgK) 		5 ALA A 793
LEU A 796
ALA A 797
PHE A 800
THR A 801
 None
 0.40A 5k9dA-5cjuA:
1.7		 5k9dA-5cjuA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5da8 60 KDA CHAPERONIN

(Chlorobaculum
tepidum) 		PF00118
(Cpn60_TCP1) 		5 ALA A  78
ALA A 504
THR A 501
THR A  90
PRO A 450
 None
None
None
SO4  A 601 (-3.6A)
None
 1.19A 5k9dA-5da8A:
undetectable		 5k9dA-5da8A:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ez3 ACYL-COA
DEHYDROGENASE

(Brucella
melitensis) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M) 		5 ALA A 152
LEU A 151
ALA A 149
THR A 145
THR A 304
 None
None
None
MRD  A 601 (-3.7A)
MPD  A 602 ( 4.6A)
 1.16A 5k9dA-5ez3A:
undetectable		 5k9dA-5ez3A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fql IDURONATE-2-SULFATAS
E

(Homo sapiens) 		PF00884
(Sulfatase) 		5 ALA A 222
LEU A  41
THR A 327
PHE A 219
LEU A 209
 None
 1.19A 5k9dA-5fqlA:
undetectable		 5k9dA-5fqlA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hss LINALOOL
DEHYDRATASE/ISOMERAS
E

(Castellaniella
defragrans) 		no annotation 5 LEU A 294
ALA A 295
PHE A 298
THR A 299
THR A 282
 None
 0.95A 5k9dA-5hssA:
undetectable		 5k9dA-5hssA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i61 POTENTIAL
RNA-DEPENDENT RNA
POLYMERASE

(Human
picobirnavirus) 		no annotation 5 ALA B 182
ALA B 307
PHE B  23
TYR B  22
LEU B  19
 None
 1.06A 5k9dA-5i61B:
undetectable		 5k9dA-5i61B:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i7q PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A,FKBP-TYPE 16
KDA PEPTIDYL-PROLYL
CIS-TRANS
ISOMERASE,PEPTIDYL-P
ROLYL CIS-TRANS
ISOMERASE FKBP1A

(Escherichia
coli;
Homo sapiens) 		PF00254
(FKBP_C) 		5 LEU A 152
PHE A  48
LEU A  50
THR A  21
PRO A  16
 None
 1.20A 5k9dA-5i7qA:
undetectable		 5k9dA-5i7qA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j9g GLYCERALDEHYDE-3-P
DEHYDROGENASE

(Lactobacillus
acidophilus) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		5 ALA A  46
HIS A  47
LEU A  49
PHE A  58
THR A  57
 None
 0.75A 5k9dA-5j9gA:
undetectable		 5k9dA-5j9gA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lq3 CMEB

(Campylobacter
jejuni) 		PF00873
(ACR_tran) 		5 ALA A 403
LEU A 402
ALA A 399
LEU A 385
THR A 381
 None
 1.17A 5k9dA-5lq3A:
undetectable		 5k9dA-5lq3A:
15.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mvd DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL

(Homo sapiens) 		PF01180
(DHO_dh) 		11 MET A  43
ALA A  55
HIS A  56
ALA A  59
PHE A  62
THR A  63
PHE A  98
TYR A 356
LEU A 359
THR A 360
PRO A 364
 U91  A 403 (-4.1A)
U91  A 403 (-3.6A)
U91  A 403 (-4.1A)
U91  A 403 (-3.3A)
None
U91  A 403 ( 4.9A)
None
FMN  A 401 ( 4.2A)
U91  A 403 ( 4.3A)
U91  A 403 (-3.9A)
U91  A 403 ( 4.3A)
 0.15A 5k9dA-5mvdA:
62.3		 5k9dA-5mvdA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mvd DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL

(Homo sapiens) 		PF01180
(DHO_dh) 		11 MET A  43
ALA A  55
HIS A  56
LEU A  58
ALA A  59
THR A  63
PHE A  98
TYR A 356
LEU A 359
THR A 360
PRO A 364
 U91  A 403 (-4.1A)
U91  A 403 (-3.6A)
U91  A 403 (-4.1A)
None
U91  A 403 (-3.3A)
U91  A 403 ( 4.9A)
None
FMN  A 401 ( 4.2A)
U91  A 403 ( 4.3A)
U91  A 403 (-3.9A)
U91  A 403 ( 4.3A)
 0.38A 5k9dA-5mvdA:
62.3		 5k9dA-5mvdA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n6m APOLIPOPROTEIN
N-ACYLTRANSFERASE

(Pseudomonas
aeruginosa) 		PF00795
(CN_hydrolase) 		5 ALA A 133
LEU A 130
ALA A 129
PHE A 173
LEU A 488
 None
 1.09A 5k9dA-5n6mA:
undetectable		 5k9dA-5n6mA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5npr UDP-N-ACETYLGLUCOSAM
INE--PEPTIDE
N-ACETYLGLUCOSAMINYL
TRANSFERASE 110 KDA
SUBUNIT

(Homo sapiens) 		no annotation 5 ALA A 946
HIS A 920
THR A 940
LEU A 916
THR A 914
 None
 1.01A 5k9dA-5nprA:
undetectable		 5k9dA-5nprA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tce DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL

(Homo sapiens) 		no annotation 5 ALA A  23
HIS A  24
ALA A  27
PHE A  30
THR A  31
 None
 1.04A 5k9dA-5tceA:
undetectable		 5k9dA-5tceA:
97.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tce DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL

(Homo sapiens) 		no annotation 5 ALA A  23
HIS A  24
LEU A  26
ALA A  27
THR A  31
 None
 0.64A 5k9dA-5tceA:
undetectable		 5k9dA-5tceA:
97.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ty7 PENICILLIN-BINDING
PROTEIN 4

(Staphylococcus
aureus) 		no annotation 5 ALA A 143
LEU A 147
PHE A 158
THR A 155
LEU A 187
 None
 1.19A 5k9dA-5ty7A:
undetectable		 5k9dA-5ty7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v36 GLUTATHIONE
REDUCTASE

(Streptococcus
mutans) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 ALA A 138
LEU A 301
ALA A 300
THR A 293
LEU A 272
 FAD  A 501 (-4.8A)
None
None
None
None
 1.21A 5k9dA-5v36A:
undetectable		 5k9dA-5v36A:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5van BETA-KLOTHO

(Homo sapiens) 		no annotation 5 ALA A 718
HIS A 719
LEU A 721
ALA A 722
LEU A 641
 None
 0.79A 5k9dA-5vanA:
7.2		 5k9dA-5vanA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vmt GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Neisseria
gonorrhoeae) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		5 ALA A 232
HIS A 178
TYR A 313
LEU A 242
THR A 243
 None
 1.15A 5k9dA-5vmtA:
undetectable		 5k9dA-5vmtA:
25.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vrc BIFUNCTIONAL
COENZYME PQQ
SYNTHESIS PROTEIN
C/D

(Methylobacterium
extorquens) 		no annotation 5 ALA A  58
LEU A  59
ALA A  56
PHE A  40
LEU A  49
 None
 1.20A 5k9dA-5vrcA:
undetectable		 5k9dA-5vrcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w21 KLOTHO

(Homo sapiens) 		no annotation 5 ALA A 706
HIS A 707
LEU A 709
ALA A 710
LEU A 637
 None
 0.97A 5k9dA-5w21A:
3.2		 5k9dA-5w21A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x6x MRNA CAPPING ENZYME
P5

(Rice dwarf
virus) 		no annotation 5 HIS C 704
LEU C 625
PHE C 629
THR C 630
LEU C 706
 None
None
None
EDO  C 901 (-4.0A)
None
 1.09A 5k9dA-5x6xC:
undetectable		 5k9dA-5x6xC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xn8 GLYCEROL
DEHYDROGENASE

(unidentified) 		PF00465
(Fe-ADH) 		5 MET A 339
ALA A 255
HIS A 254
ALA A 253
THR A 279
 None
None
ZN  A 401 (-3.4A)
None
None
 1.08A 5k9dA-5xn8A:
3.0		 5k9dA-5xn8A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z06 BDI_3064 PROTEIN

(Parabacteroides
distasonis) 		no annotation 5 LEU A 634
ALA A 635
PHE A 637
TYR A 556
LEU A 559
 None
 1.10A 5k9dA-5z06A:
undetectable		 5k9dA-5z06A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bev THIOSULFATE
SULFURTRANSFERASE/RH
ODANESE-LIKE
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		no annotation 5 ALA A  88
LEU A  91
ALA A  92
LEU A  75
PRO A  68
 None
 1.01A 5k9dA-6bevA:
undetectable		 5k9dA-6bevA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cy1 SIGNAL RECOGNITION
PARTICLE RECEPTOR
FTSY

(Elizabethkingia
anophelis) 		no annotation 5 ALA A 248
ALA A 252
PHE A 255
THR A 256
PHE A 285
 None
 0.89A 5k9dA-6cy1A:
undetectable		 5k9dA-6cy1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cza -

(-) 		no annotation 5 ALA A 505
HIS A 506
ALA A 479
PHE A 514
LEU A 498
 None
MGD  A 903 ( 4.4A)
None
None
None
 1.18A 5k9dA-6czaA:
undetectable		 5k9dA-6czaA:
undetectable