SIMILAR PATTERNS OF AMINO ACIDS FOR 5K7U_A_SAMA601_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cjy PROTEIN (CYTOSOLIC
PHOSPHOLIPASE A2)


(Homo sapiens)
PF00168
(C2)
PF01735
(PLA2_B)
3 ASP A 143
ASN A 497
GLN A  15
None
0.68A 5k7uA-1cjyA:
0.8
5k7uA-1cjyA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f9p CONNECTIVE TISSUE
ACTIVATING
PEPTIDE-III


(Homo sapiens)
PF00048
(IL8)
3 ASP A  18
ASN A  52
GLN A  53
None
0.82A 5k7uA-1f9pA:
undetectable
5k7uA-1f9pA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h79 ANAEROBIC
RIBONUCLEOTIDE-TRIPH
OSPHATE REDUCTASE
LARGE CHAIN


(Escherichia
virus T4)
PF13597
(NRDD)
3 ASP A 170
ASN A 217
GLN A 176
None
0.68A 5k7uA-1h79A:
0.3
5k7uA-1h79A:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1idu VANADIUM
CHLOROPEROXIDASE


(Curvularia
inaequalis)
PF01569
(PAP2)
3 ASP A 456
ASN A 132
GLN A 136
None
0.71A 5k7uA-1iduA:
undetectable
5k7uA-1iduA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jhd SULFATE
ADENYLYLTRANSFERASE


(Sulfur-oxidizing
endosymbiont of
Riftia
pachyptila)
PF01747
(ATP-sulfurylase)
PF14306
(PUA_2)
3 ASP A   8
ASN A 286
GLN A 285
SO4  A1001 (-3.8A)
None
None
0.56A 5k7uA-1jhdA:
undetectable
5k7uA-1jhdA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kwc 2,3-DIHYDROXYBIPHENY
L DIOXYGENASE


(Pseudomonas sp.
KKS102)
PF00903
(Glyoxalase)
3 ASP B 243
ASN B 190
GLN B 141
BPY  B 401 (-3.9A)
None
None
0.79A 5k7uA-1kwcB:
0.7
5k7uA-1kwcB:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lkd BIPHENYL-2,3-DIOL
1,2-DIOXYGENASE


(Paraburkholderia
xenovorans)
PF00903
(Glyoxalase)
3 ASP A 244
ASN A 191
GLN A 142
BP6  A 300 ( 4.4A)
None
None
0.83A 5k7uA-1lkdA:
undetectable
5k7uA-1lkdA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s70 130 KDA
MYOSIN-BINDING
SUBUNIT OF SMOOTH
MUSCLE MYOSIN
PHOPHATASE (M130)


(Gallus gallus)
PF12796
(Ank_2)
3 ASP B 257
ASN B 288
GLN B 284
None
0.83A 5k7uA-1s70B:
undetectable
5k7uA-1s70B:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t4b ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE


(Escherichia
coli)
PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC)
3 ASP A 154
ASN A 250
GLN A 246
None
0.65A 5k7uA-1t4bA:
undetectable
5k7uA-1t4bA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v71 HYPOTHETICAL PROTEIN
C320.14 IN
CHROMOSOME III


(Schizosaccharomyces
pombe)
PF00291
(PALP)
3 ASP A 228
ASN A 213
GLN A 217
None
0.65A 5k7uA-1v71A:
0.2
5k7uA-1v71A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xdq BACTERIAL SULFITE
OXIDASE


(Escherichia
coli)
PF00174
(Oxidored_molyb)
3 ASP A  38
ASN A  44
GLN A 188
None
MTE  A 301 (-4.0A)
None
0.83A 5k7uA-1xdqA:
undetectable
5k7uA-1xdqA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xvt CROTONOBETAINYL-COA:
CARNITINE
COA-TRANSFERASE


(Escherichia
coli)
PF02515
(CoA_transf_3)
3 ASP A 230
ASN A 154
GLN A 153
None
0.81A 5k7uA-1xvtA:
undetectable
5k7uA-1xvtA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z68 FIBROBLAST
ACTIVATION PROTEIN,
ALPHA SUBUNIT


(Homo sapiens)
PF00326
(Peptidase_S9)
PF00930
(DPPIV_N)
3 ASP A 478
ASN A  80
GLN A  65
None
0.71A 5k7uA-1z68A:
undetectable
5k7uA-1z68A:
14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2adc POLYPYRIMIDINE
TRACT-BINDING
PROTEIN 1


(Homo sapiens)
PF00076
(RRM_1)
PF13893
(RRM_5)
3 ASP A 383
ASN A 413
GLN A 412
None
0.77A 5k7uA-2adcA:
undetectable
5k7uA-2adcA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bxy MALTOOLIGOSYLTREHALO
SE TREHALOHYDROLASE


(Deinococcus
radiodurans)
PF00128
(Alpha-amylase)
PF02922
(CBM_48)
PF11941
(DUF3459)
3 ASP A 329
ASN A 398
GLN A 401
None
BME  A1608 (-4.3A)
None
0.75A 5k7uA-2bxyA:
undetectable
5k7uA-2bxyA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d4y FLAGELLAR
HOOK-ASSOCIATED
PROTEIN 1


(Salmonella
enterica)
no annotation 3 ASP A 180
ASN A 225
GLN A 219
None
0.77A 5k7uA-2d4yA:
undetectable
5k7uA-2d4yA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2et6 (3R)-HYDROXYACYL-COA
DEHYDROGENASE


(Candida
tropicalis)
PF00106
(adh_short)
3 ASP A 279
ASN A 586
GLN A 553
None
0.65A 5k7uA-2et6A:
undetectable
5k7uA-2et6A:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i6t UBIQUITIN-CONJUGATIN
G ENZYME E2-LIKE
ISOFORM A


(Homo sapiens)
PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C)
3 ASP A 399
ASN A 320
GLN A 324
None
0.81A 5k7uA-2i6tA:
undetectable
5k7uA-2i6tA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iik 3-KETOACYL-COA
THIOLASE,
PEROXISOMAL


(Homo sapiens)
PF00108
(Thiolase_N)
PF02803
(Thiolase_C)
3 ASP A 281
ASN A  90
GLN A  93
None
0.63A 5k7uA-2iikA:
undetectable
5k7uA-2iikA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j04 HYPOTHETICAL PROTEIN
YPL007C


(Saccharomyces
cerevisiae)
PF12660
(zf-TFIIIC)
3 ASP A  70
ASN A 105
GLN A  83
None
0.78A 5k7uA-2j04A:
undetectable
5k7uA-2j04A:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jfe CYTOSOLIC
BETA-GLUCOSIDASE


(Homo sapiens)
PF00232
(Glyco_hydro_1)
3 ASP X 302
ASN X 410
GLN X 412
None
0.79A 5k7uA-2jfeX:
undetectable
5k7uA-2jfeX:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ox8 SCAVENGER RECEPTOR
WITH C-TYPE LECTIN
TYPE I


(Homo sapiens)
PF00059
(Lectin_C)
3 ASP A 707
ASN A 718
GLN A 694
ZN  A   4 (-2.8A)
None
None
0.73A 5k7uA-2ox8A:
undetectable
5k7uA-2ox8A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pi5 DNA-DIRECTED RNA
POLYMERASE


(Escherichia
virus T7)
PF00940
(RNA_pol)
PF14700
(RPOL_N)
3 ASP A 770
ASN A 762
GLN A 744
None
0.70A 5k7uA-2pi5A:
undetectable
5k7uA-2pi5A:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qmx PREPHENATE
DEHYDRATASE


(Chlorobaculum
tepidum)
PF00800
(PDT)
3 ASP A  34
ASN A  62
GLN A  61
None
0.79A 5k7uA-2qmxA:
undetectable
5k7uA-2qmxA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rem DISULFIDE
OXIDOREDUCTASE


(Xylella
fastidiosa)
PF13462
(Thioredoxin_4)
3 ASP A  73
ASN A 109
GLN A 108
None
0.80A 5k7uA-2remA:
undetectable
5k7uA-2remA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v24 SPRY
DOMAIN-CONTAINING
SOCS BOX PROTEIN 4


(Homo sapiens)
PF00622
(SPRY)
3 ASP A 193
ASN A 103
GLN A 101
None
0.76A 5k7uA-2v24A:
undetectable
5k7uA-2v24A:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v6u PTERIN-4A-CARBINOLAM
INE DEHYDRATASE


(Toxoplasma
gondii)
PF01329
(Pterin_4a)
3 ASP A  73
ASN A  70
GLN A  38
None
0.72A 5k7uA-2v6uA:
undetectable
5k7uA-2v6uA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yk0 ERYTHROCYTE MEMBRANE
PROTEIN 1


(Plasmodium
falciparum)
PF03011
(PFEMP)
PF05424
(Duffy_binding)
PF15447
(NTS)
3 ASP A 353
ASN A 362
GLN A 363
None
0.66A 5k7uA-2yk0A:
undetectable
5k7uA-2yk0A:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bkh LYTIC
TRANSGLYCOSYLASE


(Pseudomonas
virus phiKZ)
PF01464
(SLT)
PF01471
(PG_binding_1)
3 ASP A 195
ASN A 249
GLN A 245
None
0.83A 5k7uA-3bkhA:
undetectable
5k7uA-3bkhA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3czc RMPB

(Streptococcus
mutans)
PF02302
(PTS_IIB)
3 ASP A  80
ASN A  24
GLN A  28
None
0.81A 5k7uA-3czcA:
undetectable
5k7uA-3czcA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dqq PUTATIVE TRNA
SYNTHASE


(Salmonella
enterica)
PF07005
(DUF1537)
PF17042
(DUF1357_C)
3 ASP A   9
ASN A  32
GLN A  30
None
0.76A 5k7uA-3dqqA:
undetectable
5k7uA-3dqqA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fqd PROTEIN DIN1

(Schizosaccharomyces
pombe)
PF08652
(RAI1)
3 ASP B 118
ASN B  87
GLN B  85
None
0.82A 5k7uA-3fqdB:
undetectable
5k7uA-3fqdB:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gbw E3 UBIQUITIN-PROTEIN
LIGASE MYCBP2


(Mus musculus)
PF08005
(PHR)
3 ASP A1343
ASN A1235
GLN A1381
None
0.78A 5k7uA-3gbwA:
undetectable
5k7uA-3gbwA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i0m DNA REPAIR AND
TELOMERE MAINTENANCE
PROTEIN NBS1


(Schizosaccharomyces
pombe)
PF00498
(FHA)
3 ASP A  74
ASN A  89
GLN A  88
None
0.83A 5k7uA-3i0mA:
undetectable
5k7uA-3i0mA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3igz COFACTOR-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE


(Leishmania
mexicana)
PF01676
(Metalloenzyme)
PF06415
(iPGM_N)
3 ASP B 170
ASN B 391
GLN B 389
None
0.70A 5k7uA-3igzB:
undetectable
5k7uA-3igzB:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ldf PUTATIVE
UNCHARACTERIZED
PROTEIN SMU.776


(Streptococcus
mutans)
PF10672
(Methyltrans_SAM)
3 ASP A 372
ASN A 101
GLN A 102
None
0.48A 5k7uA-3ldfA:
undetectable
5k7uA-3ldfA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m07 PUTATIVE ALPHA
AMYLASE


(Salmonella
enterica)
PF00128
(Alpha-amylase)
PF11941
(DUF3459)
3 ASP A 323
ASN A 391
GLN A 394
None
0.82A 5k7uA-3m07A:
undetectable
5k7uA-3m07A:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mg3 ORANGE
CAROTENOID-BINDING
PROTEIN


(Synechocystis
sp. PCC 6803)
PF02136
(NTF2)
PF09150
(Carot_N)
3 ASP A 209
ASN A 247
GLN A 246
None
0.73A 5k7uA-3mg3A:
undetectable
5k7uA-3mg3A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mwn PHYCOERYTHRIN

(Phormidium
tenue)
PF00502
(Phycobilisome)
3 ASP A1057
ASN A1080
GLN A1076
None
0.79A 5k7uA-3mwnA:
undetectable
5k7uA-3mwnA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oo9 ABC TRANSPORTER
BINDING PROTEIN ACBH


(Actinoplanes
sp. SE50/110)
PF01547
(SBP_bac_1)
3 ASP A 286
ASN A 254
GLN A 255
None
None
GOL  A 414 (-3.8A)
0.80A 5k7uA-3oo9A:
undetectable
5k7uA-3oo9A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opw DNA
DAMAGE-RESPONSIVE
TRANSCRIPTIONAL
REPRESSOR RPH1


(Saccharomyces
cerevisiae)
PF02373
(JmjC)
PF02375
(JmjN)
3 ASP A 186
ASN A  89
GLN A  76
None
0.76A 5k7uA-3opwA:
undetectable
5k7uA-3opwA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pc3 CG1753, ISOFORM A

(Drosophila
melanogaster)
PF00291
(PALP)
PF00571
(CBS)
3 ASP A  89
ASN A 197
GLN A 191
None
P1T  A 702 ( 4.7A)
P1T  A 702 (-2.9A)
0.78A 5k7uA-3pc3A:
undetectable
5k7uA-3pc3A:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pqh GENE PRODUCT 138

(unidentified
phage)
no annotation 3 ASP A 169
ASN A 173
GLN A 188
None
0.79A 5k7uA-3pqhA:
undetectable
5k7uA-3pqhA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pqi GENE PRODUCT 138

(unidentified
phage)
no annotation 3 ASP A 169
ASN A 173
GLN A 188
None
0.81A 5k7uA-3pqiA:
undetectable
5k7uA-3pqiA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s51 FANCONI ANEMIA GROUP
I PROTEIN HOMOLOG


(Mus musculus)
PF14674
(FANCI_S1-cap)
PF14675
(FANCI_S1)
PF14676
(FANCI_S2)
PF14677
(FANCI_S3)
PF14678
(FANCI_S4)
PF14679
(FANCI_HD1)
PF14680
(FANCI_HD2)
3 ASP A 610
ASN A 545
GLN A 503
None
0.80A 5k7uA-3s51A:
undetectable
5k7uA-3s51A:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3syj ADHESION AND
PENETRATION PROTEIN
AUTOTRANSPORTER


(Haemophilus
influenzae)
PF02395
(Peptidase_S6)
PF03212
(Pertactin)
3 ASP A 487
ASN A 530
GLN A 533
None
0.78A 5k7uA-3syjA:
undetectable
5k7uA-3syjA:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wme ATP-BINDING
CASSETTE, SUB-FAMILY
B, MEMBER 1


(Cyanidioschyzon
merolae)
PF00005
(ABC_tran)
PF00664
(ABC_membrane)
3 ASP A 402
ASN A 244
GLN A 395
None
0.80A 5k7uA-3wmeA:
undetectable
5k7uA-3wmeA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4akm LYSOSOME-ASSOCIATED
MEMBRANE
GLYCOPROTEIN 3


(Homo sapiens)
PF01299
(Lamp)
3 ASP A 357
ASN A 262
GLN A 245
None
0.75A 5k7uA-4akmA:
undetectable
5k7uA-4akmA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4amc GLUCANSUCRASE

(Lactobacillus
reuteri)
PF01473
(CW_binding_1)
PF02324
(Glyco_hydro_70)
3 ASP A1165
ASN A1179
GLN A1171
None
0.71A 5k7uA-4amcA:
undetectable
5k7uA-4amcA:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bq4 B-AGARASE

(Saccharophagus
degradans)
PF02449
(Glyco_hydro_42)
3 ASP A 755
ASN A 533
GLN A 534
None
GAL  A1795 ( 3.3A)
AAL  A1796 ( 3.1A)
0.78A 5k7uA-4bq4A:
undetectable
5k7uA-4bq4A:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0e NOT1

(Chaetomium
thermophilum)
PF04054
(Not1)
3 ASP A2065
ASN A2110
GLN A2114
None
0.77A 5k7uA-4c0eA:
undetectable
5k7uA-4c0eA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dnx SULFATE
ADENYLYLTRANSFERASE


(Allochromatium
vinosum)
PF01747
(ATP-sulfurylase)
PF14306
(PUA_2)
3 ASP A   8
ASN A 286
GLN A 285
None
0.64A 5k7uA-4dnxA:
1.0
5k7uA-4dnxA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ew9 PECTATE LYASE

(Caldicellulosiruptor
bescii)
PF03211
(Pectate_lyase)
3 ASP A 162
ASN A 113
GLN A 111
None
DGU  A 210 (-3.4A)
UNG  A 209 ( 3.4A)
0.69A 5k7uA-4ew9A:
undetectable
5k7uA-4ew9A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fgv CHROMOSOME REGION
MAINTENANCE 1 (CRM1)
OR EXPORTIN 1 (XPO1)


(Chaetomium
thermophilum)
PF03810
(IBN_N)
PF08389
(Xpo1)
PF08767
(CRM1_C)
3 ASP A 713
ASN A 692
GLN A 706
None
0.59A 5k7uA-4fgvA:
undetectable
5k7uA-4fgvA:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gk5 DNA REPAIR PROTEIN
REV1


(Homo sapiens)
PF16727
(REV1_C)
3 ASP E1234
ASN E1226
GLN E1218
None
0.82A 5k7uA-4gk5E:
undetectable
5k7uA-4gk5E:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gkl ALPHA-AMYLASE

(Thermotoga
neapolitana)
PF00128
(Alpha-amylase)
3 ASP A 214
ASN A 255
GLN A 258
None
0.77A 5k7uA-4gklA:
undetectable
5k7uA-4gklA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i62 AMINO ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING
PROTEIN, PUTATIVE


(Streptococcus
pneumoniae)
PF00497
(SBP_bac_3)
3 ASP A 166
ASN A 129
GLN A 160
None
None
ARG  A 301 (-3.7A)
0.68A 5k7uA-4i62A:
undetectable
5k7uA-4i62A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4im9 DNA PRIMASE

(Vibrio cholerae)
PF08278
(DnaG_DnaB_bind)
3 ASP A  16
ASN A  24
GLN A  94
None
0.80A 5k7uA-4im9A:
undetectable
5k7uA-4im9A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ka8 OLIGOPEPTIDASE A

(Arabidopsis
thaliana)
PF01432
(Peptidase_M3)
3 ASP A 496
ASN A 750
GLN A 746
None
0.76A 5k7uA-4ka8A:
undetectable
5k7uA-4ka8A:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l27 CYSTATHIONINE
BETA-SYNTHASE


(Homo sapiens)
no annotation 3 ASP B 120
ASN B 228
GLN B 222
None
PLP  B 601 ( 4.9A)
None
0.64A 5k7uA-4l27B:
undetectable
5k7uA-4l27B:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l9a PUTATIVE
UNCHARACTERIZED
PROTEIN SMU.1393C


(Streptococcus
mutans)
no annotation 3 ASP A 207
ASN A 112
GLN A 113
None
0.80A 5k7uA-4l9aA:
2.0
5k7uA-4l9aA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lor COMPLEMENT C1S
SUBCOMPONENT HEAVY
CHAIN


(Homo sapiens)
PF00431
(CUB)
PF14670
(FXa_inhibition)
3 ASP A  43
ASN A  12
GLN A  15
None
0.83A 5k7uA-4lorA:
undetectable
5k7uA-4lorA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qlb PROBABLE GLYCOGEN
[STARCH] SYNTHASE


(Caenorhabditis
elegans)
PF05693
(Glycogen_syn)
3 ASP A  24
ASN A 621
GLN A 620
None
0.73A 5k7uA-4qlbA:
undetectable
5k7uA-4qlbA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r04 TOXIN A

(Clostridioides
difficile)
PF11713
(Peptidase_C80)
PF12918
(TcdB_N)
PF12919
(TcdA_TcdB)
PF12920
(TcdA_TcdB_pore)
3 ASP A 590
ASN A 613
GLN A 611
None
0.74A 5k7uA-4r04A:
undetectable
5k7uA-4r04A:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4sli INTRAMOLECULAR
TRANS-SIALIDASE


(Macrobdella
decora)
PF02973
(Sialidase)
PF13088
(BNR_2)
3 ASP A 732
ASN A 155
GLN A 708
None
0.79A 5k7uA-4sliA:
undetectable
5k7uA-4sliA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tqx SORTASE

(Streptococcus
mutans)
PF04203
(Sortase)
3 ASP A 100
ASN A 104
GLN A 239
None
0.80A 5k7uA-4tqxA:
undetectable
5k7uA-4tqxA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v3q YIII_M4_AII

(synthetic
construct)
PF00514
(Arm)
PF16186
(Arm_3)
3 ASP A  24
ASN A  66
GLN A  68
None
0.79A 5k7uA-4v3qA:
undetectable
5k7uA-4v3qA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wd9 NISIN BIOSYNTHESIS
PROTEIN NISB


(Lactococcus
lactis)
PF04738
(Lant_dehydr_N)
PF14028
(Lant_dehydr_C)
3 ASP A 607
ASN A 325
GLN A 419
None
0.83A 5k7uA-4wd9A:
undetectable
5k7uA-4wd9A:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wy4 VESICLE-ASSOCIATED
MEMBRANE PROTEIN 8
SYNAPTOSOMAL-ASSOCIA
TED PROTEIN 29


(Homo sapiens;
Homo sapiens)
PF00957
(Synaptobrevin)
no annotation
3 ASP D 218
ASN A  30
GLN D 224
None
0.76A 5k7uA-4wy4D:
undetectable
5k7uA-4wy4D:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xb0 SERINE/THREONINE-PRO
TEIN KINASE PLK2


(Homo sapiens)
PF00659
(POLO_box)
3 ASP A 585
ASN A 624
GLN A 622
None
0.78A 5k7uA-4xb0A:
undetectable
5k7uA-4xb0A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z3y BENZOYL-COA
REDUCTASE, PUTATIVE


(Geobacter
metallireducens)
PF01314
(AFOR_C)
PF02730
(AFOR_N)
3 ASP A 352
ASN A 426
GLN A 433
MTE  A 703 (-3.7A)
None
None
0.81A 5k7uA-4z3yA:
undetectable
5k7uA-4z3yA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5awf PROBABLE
ATP-DEPENDENT
TRANSPORTER SUFC


(Escherichia
coli)
PF00005
(ABC_tran)
3 ASP C 119
ASN C 104
GLN C 100
None
0.77A 5k7uA-5awfC:
1.5
5k7uA-5awfC:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cnx AMINOPEPTIDASE YPDF

(Escherichia
coli)
PF00557
(Peptidase_M24)
PF01321
(Creatinase_N)
3 ASP A 301
ASN A  26
GLN A  25
None
0.82A 5k7uA-5cnxA:
undetectable
5k7uA-5cnxA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hgr ORANGE CAROTENOID
PROTEIN (OCP)


(Nostoc sp. PCC
7120)
PF02136
(NTF2)
PF09150
(Carot_N)
3 ASP A 211
ASN A 249
GLN A 248
None
0.77A 5k7uA-5hgrA:
undetectable
5k7uA-5hgrA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hmq 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE


(Pseudomonas
putida)
PF00903
(Glyoxalase)
PF01261
(AP_endonuc_2)
PF14696
(Glyoxalase_5)
3 ASP A 109
ASN A 150
GLN A 154
None
0.77A 5k7uA-5hmqA:
undetectable
5k7uA-5hmqA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i4k MANGANESE-BINDING
LIPOPROTEIN MNTA


(Listeria
monocytogenes)
PF01297
(ZnuA)
3 ASP A 194
ASN A 198
GLN A 199
None
0.76A 5k7uA-5i4kA:
undetectable
5k7uA-5i4kA:
19.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5il0 METTL3

(Homo sapiens)
PF05063
(MT-A70)
3 ASP A 395
ASN A 549
GLN A 550
None
0.39A 5k7uA-5il0A:
35.0
5k7uA-5il0A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k3h ACYL-COENZYME A
OXIDASE


(Caenorhabditis
elegans)
PF01756
(ACOX)
PF02770
(Acyl-CoA_dh_M)
PF14749
(Acyl-CoA_ox_N)
3 ASP A 565
ASN A 572
GLN A 599
None
0.73A 5k7uA-5k3hA:
undetectable
5k7uA-5k3hA:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k3j ACYL-COENZYME A
OXIDASE


(Caenorhabditis
elegans)
PF01756
(ACOX)
PF02770
(Acyl-CoA_dh_M)
PF14749
(Acyl-CoA_ox_N)
3 ASP A 557
ASN A 564
GLN A 589
None
0.76A 5k7uA-5k3jA:
undetectable
5k7uA-5k3jA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lgx PENTAERYTHRITOL
TETRANITRATE
REDUCTASE


(Enterobacter
cloacae)
PF00724
(Oxidored_FMN)
3 ASP A 144
ASN A 242
GLN A 241
None
0.76A 5k7uA-5lgxA:
undetectable
5k7uA-5lgxA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m11 IMMUNOREACTIVE 84KD
ANTIGEN PG93


(Porphyromonas
gingivalis)
no annotation 3 ASP A 610
ASN A 653
GLN A 624
GOL  A 817 (-3.1A)
None
None
0.77A 5k7uA-5m11A:
undetectable
5k7uA-5m11A:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mg5 HYDROXYMETHYLGLUTARY
L-COA SYNTHASE


(Pseudomonas
protegens)
no annotation 3 ASP A  33
ASN A  27
GLN A  23
None
0.61A 5k7uA-5mg5A:
undetectable
5k7uA-5mg5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n9v NAD(P)(+)--ARGININE
ADP-RIBOSYLTRANSFERA
SE


(Tetrahymena
thermophila)
no annotation 3 ASP A  60
ASN A  54
GLN A  55
None
0.82A 5k7uA-5n9vA:
undetectable
5k7uA-5n9vA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oc1 ARYL-ALCOHOL OXIDASE

(Pleurotus
eryngii)
no annotation 3 ASP A 470
ASN A 325
GLN A 326
None
0.65A 5k7uA-5oc1A:
undetectable
5k7uA-5oc1A:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ohx CYSTATHIONINE
BETA-SYNTHASE


(Apis mellifera)
no annotation 3 ASP A  79
ASN A 187
GLN A 181
None
PLP  A 702 ( 4.1A)
None
0.73A 5k7uA-5ohxA:
undetectable
5k7uA-5ohxA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tey N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT


(Homo sapiens)
PF05063
(MT-A70)
3 ASP A 395
ASN A 549
GLN A 550
SAH  A 601 (-3.8A)
SAH  A 601 (-3.1A)
SAH  A 601 (-3.7A)
0.14A 5k7uA-5teyA:
32.5
5k7uA-5teyA:
37.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tj3 ALKALINE PHOSPHATASE
PAFA


(Elizabethkingia
meningoseptica)
PF01663
(Phosphodiest)
3 ASP A 320
ASN A 225
GLN A 226
None
0.61A 5k7uA-5tj3A:
1.4
5k7uA-5tj3A:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tj7 NEDD4-LIKE E3
UBIQUITIN-PROTEIN
LIGASE WWP2


(Homo sapiens)
PF00397
(WW)
PF00632
(HECT)
3 ASP A 600
ASN A 534
GLN A 530
None
0.63A 5k7uA-5tj7A:
undetectable
5k7uA-5tj7A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ui2 ORANGE
CAROTENOID-BINDING
PROTEIN


(Arthrospira
maxima)
PF02136
(NTF2)
PF09150
(Carot_N)
3 ASP A 211
ASN A 249
GLN A 248
None
SUC  A 401 (-3.6A)
None
0.80A 5k7uA-5ui2A:
undetectable
5k7uA-5ui2A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wi8 TUMOR NECROSIS
FACTOR RECEPTOR
SUPERFAMILY MEMBER 9


(Mus musculus)
no annotation 3 ASP A 104
ASN A 125
GLN A 127
None
0.80A 5k7uA-5wi8A:
undetectable
5k7uA-5wi8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wq8 TYPE II SECRETION
SYSTEM PROTEIN D


(Vibrio cholerae)
PF00263
(Secretin)
PF03958
(Secretin_N)
3 ASP A 631
ASN A 601
GLN A 597
None
0.75A 5k7uA-5wq8A:
undetectable
5k7uA-5wq8A:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
TRANSCRIPTION
ELONGATION FACTOR 1
HOMOLOG


(Komagataella
phaffii;
Komagataella
pastoris)
PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4)
PF05129
(Elf1)
3 ASP A 178
ASN M  32
GLN M  22
None
0.78A 5k7uA-5xogA:
undetectable
5k7uA-5xogA:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yfp EXOCYST COMPLEX
COMPONENT EXO84


(Saccharomyces
cerevisiae)
no annotation 3 ASP H 696
ASN H 638
GLN H 634
None
0.75A 5k7uA-5yfpH:
undetectable
5k7uA-5yfpH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z5c CYSTEINE SYNTHASE

(Fusobacterium
nucleatum)
no annotation 3 ASP A  47
ASN A 153
GLN A 147
None
PLP  A 401 ( 4.7A)
CL  A 402 (-3.5A)
0.75A 5k7uA-5z5cA:
undetectable
5k7uA-5z5cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b4h NUCLEOPORIN GLE1

(Chaetomium
thermophilum)
no annotation 3 ASP A 523
ASN A 475
GLN A 474
None
0.50A 5k7uA-6b4hA:
undetectable
5k7uA-6b4hA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c2h CYSTATHIONINE
BETA-SYNTHASE


(Saccharomyces
cerevisiae)
no annotation 3 ASP A  54
ASN A 163
GLN A 157
None
PLP  A 401 ( 4.8A)
ACT  A 402 (-3.0A)
0.75A 5k7uA-6c2hA:
undetectable
5k7uA-6c2hA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c66 CRISPR-ASSOCIATED
PROTEIN, CSE4 FAMILY


(Thermobifida
fusca)
no annotation 3 ASP B 345
ASN B 320
GLN B 316
None
0.83A 5k7uA-6c66B:
undetectable
5k7uA-6c66B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cwx RIBONUCLEASE P
PROTEIN SUBUNIT P20


(Homo sapiens)
no annotation 3 ASP A  44
ASN A  83
GLN A  87
None
FMT  A 201 (-3.9A)
None
0.62A 5k7uA-6cwxA:
2.8
5k7uA-6cwxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6v TELOMERASE
HOLOENZYME TEB
HETEROTRIMER TEB3
SUBUNIT


(Tetrahymena
thermophila)
no annotation 3 ASP F  57
ASN F  79
GLN F  80
None
0.45A 5k7uA-6d6vF:
undetectable
5k7uA-6d6vF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gh2 LAMINARIBIOSE
PHOSPHORYLASE


(Paenibacillus
sp. YM1)
no annotation 3 ASP A 432
ASN A 504
GLN A 503
None
0.82A 5k7uA-6gh2A:
undetectable
5k7uA-6gh2A:
undetectable