SIMILAR PATTERNS OF AMINO ACIDS FOR 5K7U_A_SAMA601

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b0a PROTEIN (FOLD
BIFUNCTIONAL
PROTEIN)

(Escherichia
coli) 		PF00763
(THF_DHG_CYH)
PF02882
(THF_DHG_CYH_C) 		5 ILE A 272
PRO A  34
LEU A 276
GLU A  59
PHE A  63
 None
 1.36A 5k7uA-1b0aA:
undetectable		 5k7uA-1b0aA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bkh MUCONATE LACTONIZING
ENZYME

(Pseudomonas
putida) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ILE A 220
ARG A 196
PRO A 245
LEU A 222
GLY A 219
 None
 1.20A 5k7uA-1bkhA:
undetectable		 5k7uA-1bkhA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c7j PROTEIN
(PARA-NITROBENZYL
ESTERASE)

(Bacillus
subtilis) 		PF00135
(COesterase) 		5 ILE A 212
LEU A 302
GLU A 402
HIS A 399
GLY A 187
 None
 1.19A 5k7uA-1c7jA:
undetectable		 5k7uA-1c7jA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cby DELTA-ENDOTOXIN CYTB

(Bacillus
thuringiensis) 		PF01338
(Bac_thur_toxin) 		5 ILE A  83
PRO A 188
LEU A 220
PHE A  64
GLY A  66
 None
 0.97A 5k7uA-1cbyA:
undetectable		 5k7uA-1cbyA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dct PROTEIN
(MODIFICATION
METHYLASE HAEIII)

(Haemophilus
influenzae) 		PF00145
(DNA_methylase) 		5 ASP A  50
ILE A  51
PRO A  70
LEU A  90
PHE A   7
 None
 1.00A 5k7uA-1dctA:
5.2		 5k7uA-1dctA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hgx HYPOXANTHINE-GUANINE
-XANTHINE
PHOSPHORIBOSYLTRANSF
ERASE

(Tritrichomonas
suis) 		PF00156
(Pribosyltran) 		5 ILE A 174
LEU A 131
PHE A 162
ARG A 169
GLY A 159
 None
None
5GP  A 600 ( 4.9A)
None
None
 1.35A 5k7uA-1hgxA:
undetectable		 5k7uA-1hgxA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1im8 YECO

(Haemophilus
influenzae) 		PF13649
(Methyltransf_25) 		5 ASP A 116
ILE A 117
ARG A 118
LEU A 137
GLY A  63
 SAI  A 302 (-3.1A)
SAI  A 302 (-4.1A)
SAI  A 302 ( 4.5A)
None
SAI  A 302 (-3.8A)
 1.13A 5k7uA-1im8A:
1.5		 5k7uA-1im8A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oe5 SINGLE-STRAND
SELECTIVE
MONOFUNCTIONAL
URACIL DNA
GLYCOSYLASE

(Xenopus laevis) 		no annotation 5 ILE A 222
LEU A 270
PHE A  92
ASN A 174
GLY A 223
 None
None
None
URA  A1282 (-3.0A)
None
 1.26A 5k7uA-1oe5A:
undetectable		 5k7uA-1oe5A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ukv GTP-BINDING PROTEIN
YPT1

(Saccharomyces
cerevisiae) 		PF00071
(Ras) 		5 ILE Y  61
LEU Y  13
GLU Y 159
PHE Y 162
ARG Y  27
 None
 1.30A 5k7uA-1ukvY:
undetectable		 5k7uA-1ukvY:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vey PEPTIDE DEFORMYLASE

(Leptospira
interrogans) 		PF01327
(Pep_deformylase) 		5 ILE A  60
PRO A  85
LEU A 148
GLU A 124
ARG A  80
 None
 1.31A 5k7uA-1veyA:
undetectable		 5k7uA-1veyA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vlm SAM-DEPENDENT
METHYLTRANSFERASE

(Thermotoga
maritima) 		PF08241
(Methyltransf_11) 		5 ILE A  42
PRO A  85
LEU A  86
GLU A  82
HIS A   0
 None
 1.30A 5k7uA-1vlmA:
undetectable		 5k7uA-1vlmA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w1k VANILLYL-ALCOHOL
OXIDASE

(Penicillium
simplicissimum) 		PF01565
(FAD_binding_4)
PF02913
(FAD-oxidase_C) 		5 ILE A 296
ARG A 300
LEU A 305
PHE A 353
ARG A 312
 None
 1.36A 5k7uA-1w1kA:
undetectable		 5k7uA-1w1kA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z1w TRICORN PROTEASE
INTERACTING FACTOR
F3

(Thermoplasma
acidophilum) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		5 LEU A 358
GLU A 369
PHE A 370
ARG A 371
GLY A 373
 None
 1.24A 5k7uA-1z1wA:
undetectable		 5k7uA-1z1wA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2azn PUTATIVE
5-AMINO-6-(5-PHOSPHO
RIBOSYLAMINO)URACIL
REDUCTASE

(Methanocaldococcus
jannaschii) 		PF01872
(RibD_C) 		5 ILE A 151
LEU A 139
GLU A 154
ARG A  78
GLY A  50
 None
 1.24A 5k7uA-2aznA:
undetectable		 5k7uA-2aznA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dpm PROTEIN
(ADENINE-SPECIFIC
METHYLTRANSFERASE
DPNII 1)

(Streptococcus
pneumoniae) 		PF02086
(MethyltransfD12) 		5 ASP A 177
PRO A 196
LYS A  21
GLU A  41
PHE A  43
 SAM  A 300 (-4.1A)
SAM  A 300 ( 4.1A)
SAM  A 300 (-4.8A)
None
SAM  A 300 (-4.2A)
 1.21A 5k7uA-2dpmA:
undetectable		 5k7uA-2dpmA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eke SUMO-CONJUGATING
ENZYME UBC9

(Saccharomyces
cerevisiae) 		PF00179
(UQ_con) 		5 ILE A  45
PRO A  21
LEU A 114
PHE A  24
GLY A  44
 None
 1.36A 5k7uA-2ekeA:
undetectable		 5k7uA-2ekeA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ffi 2-PYRONE-4,6-DICARBO
XYLIC ACID
HYDROLASE, PUTATIVE

(Pseudomonas
putida) 		PF04909
(Amidohydro_2) 		5 ILE A 133
LEU A 129
ARG A 110
HIS A  18
GLY A 108
 None
None
PO4  A 301 (-2.3A)
PO4  A 301 (-4.1A)
None
 1.27A 5k7uA-2ffiA:
undetectable		 5k7uA-2ffiA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i9k MODIFICATION
METHYLASE HHAI

(Haemophilus
haemolyticus) 		PF00145
(DNA_methylase) 		5 ASP A  60
ILE A  61
PRO A  80
LEU A 100
PHE A  18
 SAH  A 328 (-3.6A)
SAH  A 328 (-4.3A)
SAH  A 328 (-4.0A)
SAH  A 328 ( 4.9A)
SAH  A 328 (-4.9A)
 0.88A 5k7uA-2i9kA:
undetectable		 5k7uA-2i9kA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2inr DNA TOPOISOMERASE 4
SUBUNIT A

(Staphylococcus
aureus) 		PF00521
(DNA_topoisoIV) 		5 ILE A 179
PRO A 212
ARG A  96
HIS A  97
GLY A 167
 None
 1.05A 5k7uA-2inrA:
undetectable		 5k7uA-2inrA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j3m PROLYL-TRNA
SYNTHETASE

(Enterococcus
faecalis) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF04073
(tRNA_edit) 		5 ILE A 278
PRO A 378
PHE A 376
ASN A 337
GLY A 334
 None
 1.22A 5k7uA-2j3mA:
undetectable		 5k7uA-2j3mA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j8x URACIL-DNA
GLYCOSYLASE

(Human
gammaherpesvirus
4) 		PF03167
(UDG) 		5 ASP A 252
ARG A 254
PRO A 127
GLU A 121
ASN A 234
 None
 1.23A 5k7uA-2j8xA:
undetectable		 5k7uA-2j8xA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ltm NFU1 IRON-SULFUR
CLUSTER SCAFFOLD
HOMOLOG,
MITOCHONDRIAL

(Homo sapiens) 		PF08712
(Nfu_N) 		5 ILE A  71
LEU A  51
PHE A  66
ARG A  36
GLY A  67
 None
 1.24A 5k7uA-2ltmA:
undetectable		 5k7uA-2ltmA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nsm CARBOXYPEPTIDASE N
CATALYTIC CHAIN

(Homo sapiens) 		PF00246
(Peptidase_M14)
PF13620
(CarboxypepD_reg) 		5 ASP A  47
ILE A  98
GLU A  86
ARG A  88
ASN A  89
 None
 1.34A 5k7uA-2nsmA:
undetectable		 5k7uA-2nsmA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN

(Porphyromonas
gingivalis) 		PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C) 		5 ILE A 358
PRO A 469
LEU A 460
PHE A 359
HIS A 417
 ILE  A 358 ( 0.7A)
PRO  A 469 ( 1.1A)
LEU  A 460 ( 0.6A)
PHE  A 359 ( 1.3A)
HIS  A 417 (-1.0A)
 1.34A 5k7uA-2nvvA:
undetectable		 5k7uA-2nvvA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nx9 OXALOACETATE
DECARBOXYLASE 2,
SUBUNIT ALPHA

(Vibrio cholerae) 		PF00682
(HMGL-like)
PF02436
(PYC_OADA) 		5 ILE A 328
ARG A 332
PRO A 301
LEU A 340
GLU A 309
 None
 1.27A 5k7uA-2nx9A:
undetectable		 5k7uA-2nx9A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2okx RHAMNOSIDASE B

(Bacillus sp.
GL1) 		PF05592
(Bac_rhamnosid)
PF08531
(Bac_rhamnosid_N)
PF17389
(Bac_rhamnosid6H)
PF17390
(Bac_rhamnosid_C) 		5 PRO A 430
LEU A 211
GLU A 433
PHE A 432
GLY A 435
 None
 1.32A 5k7uA-2okxA:
undetectable		 5k7uA-2okxA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rci TYPE-2BA CYTOLYTIC
DELTA-ENDOTOXIN

(Bacillus
thuringiensis) 		PF01338
(Bac_thur_toxin) 		5 ILE A  83
PRO A 188
LEU A 220
PHE A  64
GLY A  66
 ILE  A  83 ( 0.7A)
PRO  A 188 ( 1.1A)
LEU  A 220 ( 0.6A)
PHE  A  64 ( 1.3A)
GLY  A  66 ( 0.0A)
 0.90A 5k7uA-2rciA:
undetectable		 5k7uA-2rciA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vd9 ALANINE RACEMASE

(Bacillus
anthracis) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		5 ILE A 337
PRO A 248
LEU A 232
GLU A  13
GLY A 338
 None
None
None
MLY  A 333 ( 3.7A)
None
 1.19A 5k7uA-2vd9A:
undetectable		 5k7uA-2vd9A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2we8 XANTHINE
DEHYDROGENASE

(Mycolicibacterium
smegmatis) 		PF02625
(XdhC_CoxI)
PF13478
(XdhC_C) 		5 ASP A 270
ILE A 269
PRO A 296
GLU A 265
GLY A 267
 None
 1.35A 5k7uA-2we8A:
undetectable		 5k7uA-2we8A:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xh6 HEAT-LABILE
ENTEROTOXIN B CHAIN

(Clostridium
perfringens) 		PF03505
(Clenterotox) 		5 ASP A 151
ILE A 142
ARG A 143
LEU A  41
GLY A 153
 None
 1.32A 5k7uA-2xh6A:
undetectable		 5k7uA-2xh6A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z95 GDP-D-MANNOSE
DEHYDRATASE

(Aquifex
aeolicus) 		PF16363
(GDP_Man_Dehyd) 		5 ILE A 288
LEU A 199
GLU A 269
ARG A 254
GLY A 279
 None
 1.35A 5k7uA-2z95A:
undetectable		 5k7uA-2z95A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zqp PREPROTEIN
TRANSLOCASE SECY
SUBUNIT

(Thermus
thermophilus) 		PF00344
(SecY) 		5 ILE Y 314
PRO Y 284
PHE Y 304
ASN Y 302
GLY Y 311
 None
 1.21A 5k7uA-2zqpY:
undetectable		 5k7uA-2zqpY:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ak1 SUPEROXIDE DISMUTASE
[MN/FE]

(Aeropyrum
pernix) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		5 ILE A 104
LEU A 133
GLU A 112
PHE A 114
GLY A 110
 None
 1.30A 5k7uA-3ak1A:
undetectable		 5k7uA-3ak1A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayx MEMBRANE-BOUND
HYDROGENASE LARGE
SUBUNIT

(Hydrogenovibrio
marinus) 		PF00374
(NiFeSe_Hases) 		6 ILE A 182
ARG A  26
PRO A 134
LEU A 129
PHE A 183
GLY A 181
 None
 1.31A 5k7uA-3ayxA:
undetectable		 5k7uA-3ayxA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3baz HYDROXYPHENYLPYRUVAT
E REDUCTASE

(Plectranthus
scutellarioides) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 PRO A 265
LEU A 268
PHE A 258
ARG A 260
GLY A 233
 None
 1.25A 5k7uA-3bazA:
undetectable		 5k7uA-3bazA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ccq 50S RIBOSOMAL
PROTEIN L4P

(Haloarcula
marismortui) 		PF00573
(Ribosomal_L4) 		5 ASP C  29
ILE C  31
ARG C  27
GLU C 221
GLY C  32
 None
None
G  0 657 ( 3.3A)
None
None
 1.27A 5k7uA-3ccqC:
undetectable		 5k7uA-3ccqC:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fqd 5'-3'
EXORIBONUCLEASE 2

(Schizosaccharomyces
pombe) 		PF03159
(XRN_N) 		5 ARG A 194
LEU A  98
PHE A 213
ARG A 218
HIS A 847
 None
 1.17A 5k7uA-3fqdA:
undetectable		 5k7uA-3fqdA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gux PUTATIVE
ZN-DEPENDENT
EXOPEPTIDASE

(Bacteroides
vulgatus) 		PF04389
(Peptidase_M28) 		5 ASP A 174
ILE A 119
ARG A 118
GLU A 245
GLY A 219
 None
 1.36A 5k7uA-3guxA:
2.3		 5k7uA-3guxA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3htn PUTATIVE DNA BINDING
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF03479
(DUF296) 		5 ILE A  88
LEU A 148
GLU A 110
ARG A 109
GLY A  89
 None
 1.34A 5k7uA-3htnA:
undetectable		 5k7uA-3htnA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3htz ALANYL-TRNA
SYNTHETASE

(Aquifex
aeolicus) 		PF01411
(tRNA-synt_2c) 		5 ILE A 225
LEU A 118
GLU A 191
ASN A 194
GLY A 221
 None
 1.33A 5k7uA-3htzA:
undetectable		 5k7uA-3htzA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jyf 2',3'-CYCLIC
NUCLEOTIDE
2'-PHOSPHODIESTERASE
/3'-NUCLEOTIDASE
BIFUNCTIONAL
PERIPLASMIC PROTEIN

(Klebsiella
pneumoniae) 		PF00149
(Metallophos) 		5 ASP A 278
ILE A 306
GLU A 318
HIS A 330
GLY A  36
 None
 1.11A 5k7uA-3jyfA:
undetectable		 5k7uA-3jyfA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k5j SUPPRESSOR OF FUSED
FAMILY PROTEIN

(Neisseria
gonorrhoeae) 		PF05076
(SUFU) 		5 ILE A 167
LEU A 140
GLU A 164
PHE A 162
GLY A 166
 None
 1.36A 5k7uA-3k5jA:
undetectable		 5k7uA-3k5jA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kxy EXOENZYME S
SYNTHESIS PROTEIN C

(Pseudomonas
aeruginosa) 		PF05932
(CesT) 		5 ILE A  18
LEU A  33
GLU A  13
PHE A  14
GLY A  16
 None
 1.22A 5k7uA-3kxyA:
undetectable		 5k7uA-3kxyA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kzx HAD-SUPERFAMILY
HYDROLASE, SUBFAMILY
IA, VARIANT 1

(Ehrlichia
chaffeensis) 		PF13419
(HAD_2) 		5 ILE A 162
LEU A  15
PHE A 197
ARG A 201
ASN A 202
 None
 1.05A 5k7uA-3kzxA:
undetectable		 5k7uA-3kzxA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lpx DNA GYRASE, A
SUBUNIT

(Colwellia
psychrerythraea) 		PF00521
(DNA_topoisoIV) 		5 ILE A 182
PRO A 215
LEU A 332
ARG A  99
GLY A 170
 None
 1.33A 5k7uA-3lpxA:
undetectable		 5k7uA-3lpxA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m62 UBIQUITIN
CONJUGATION FACTOR
E4

(Saccharomyces
cerevisiae) 		PF04564
(U-box)
PF10408
(Ufd2P_core) 		5 ILE A 120
LEU A 102
GLU A  58
PHE A  57
GLY A 119
 None
 1.27A 5k7uA-3m62A:
undetectable		 5k7uA-3m62A:
12.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m7a UNCHARACTERIZED
PROTEIN

(Novosphingobium
aromaticivorans) 		PF02643
(DUF192) 		5 ILE A 147
GLU A  85
PHE A  61
ARG A  62
GLY A  87
 None
 1.22A 5k7uA-3m7aA:
undetectable		 5k7uA-3m7aA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nul PROFILIN I

(Arabidopsis
thaliana) 		PF00235
(Profilin) 		5 PRO A  40
LEU A  42
PHE A  39
HIS A  19
GLY A 104
 None
 1.12A 5k7uA-3nulA:
undetectable		 5k7uA-3nulA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3obi FORMYLTETRAHYDROFOLA
TE DEFORMYLASE

(Rhodopseudomonas
palustris) 		PF00551
(Formyl_trans_N) 		5 ILE A  72
LEU A  10
PHE A  69
ARG A  66
GLY A  70
 None
 1.32A 5k7uA-3obiA:
undetectable		 5k7uA-3obiA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3one ADENOSYLHOMOCYSTEINA
SE

(Lupinus luteus) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		5 ILE A 387
LEU A 360
PHE A 380
ASN A 384
GLY A 386
 None
 1.13A 5k7uA-3oneA:
undetectable		 5k7uA-3oneA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qxi ENOYL-COA HYDRATASE
ECHA1

(Mycobacterium
marinum) 		PF00378
(ECH_1) 		5 PRO A  96
LEU A 100
GLU A  93
PHE A  91
GLY A  90
 None
 1.20A 5k7uA-3qxiA:
undetectable		 5k7uA-3qxiA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r2i EXOTOXIN 5

(Staphylococcus
aureus) 		PF02876
(Stap_Strp_tox_C)
PF09199
(SSL_OB) 		5 ASP A 169
ILE A 172
ARG A 173
LEU A 206
ASN A 226
 None
 0.81A 5k7uA-3r2iA:
undetectable		 5k7uA-3r2iA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r2t PUTATIVE
UNCHARACTERIZED
PROTEIN

(Staphylococcus
aureus) 		PF02876
(Stap_Strp_tox_C)
PF09199
(SSL_OB) 		5 ASP A 169
ILE A 172
ARG A 173
LEU A 206
ASN A 226
 None
 0.83A 5k7uA-3r2tA:
undetectable		 5k7uA-3r2tA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rg1 CD180 MOLECULE

(Bos taurus) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		5 ILE A 143
PRO A 171
LEU A 148
PHE A 170
ASN A 165
 None
 1.25A 5k7uA-3rg1A:
undetectable		 5k7uA-3rg1A:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w21 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Burkholderia
ambifaria) 		no annotation 5 ILE A 127
LEU A 170
GLU A 134
PHE A 135
ASN A 104
 None
 1.26A 5k7uA-3w21A:
undetectable		 5k7uA-3w21A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bx9 VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 33A

(Homo sapiens) 		PF00995
(Sec1) 		5 ILE A 111
LEU A 125
GLU A 139
PHE A 113
HIS A 174
 None
 1.31A 5k7uA-4bx9A:
undetectable		 5k7uA-4bx9A:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4emb 2,3-BISPHOSPHOGLYCER
ATE-DEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Borreliella
burgdorferi) 		PF00300
(His_Phos_1) 		5 ASP A  35
ILE A  38
ARG A  65
HIS A 187
GLY A  37
 None
 1.00A 5k7uA-4embA:
1.9		 5k7uA-4embA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fdj N-ACETYLGALACTOSAMIN
E-6-SULFATASE

(Homo sapiens) 		PF00884
(Sulfatase)
PF14707
(Sulfatase_C) 		5 ILE A 137
PRO A 125
LEU A  87
GLU A 158
PHE A 156
 None
 1.34A 5k7uA-4fdjA:
undetectable		 5k7uA-4fdjA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gek TRNA
(CMO5U34)-METHYLTRAN
SFERASE

(Escherichia
coli) 		PF13649
(Methyltransf_25) 		5 ASP A 117
ILE A 118
ARG A 119
ASN A 132
GLY A  64
 GEK  A 302 (-3.2A)
GEK  A 302 (-3.8A)
None
GEK  A 302 (-3.7A)
GEK  A 302 (-3.7A)
 1.16A 5k7uA-4gekA:
1.4		 5k7uA-4gekA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gek TRNA
(CMO5U34)-METHYLTRAN
SFERASE

(Escherichia
coli) 		PF13649
(Methyltransf_25) 		5 ASP A 117
ILE A 118
ARG A 119
LEU A 138
GLY A  64
 GEK  A 302 (-3.2A)
GEK  A 302 (-3.8A)
None
None
GEK  A 302 (-3.7A)
 1.09A 5k7uA-4gekA:
1.4		 5k7uA-4gekA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hxq ARGINASE-1

(Homo sapiens) 		PF00491
(Arginase) 		5 ILE A 208
LEU A 252
GLU A 214
ARG A 205
GLY A 207
 None
 1.24A 5k7uA-4hxqA:
1.8		 5k7uA-4hxqA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hzp BIFUNCTIONAL
METHYLMALONYL-COA:AC
P
ACYLTRANSFERASE/DECA
RBOXYLASE

(Streptomyces
atroolivaceus) 		no annotation 5 ASP A 255
ARG A  69
PRO A 128
GLU A  75
GLY A  73
 None
SO4  A 404 (-3.0A)
None
None
None
 1.18A 5k7uA-4hzpA:
undetectable		 5k7uA-4hzpA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i3h TOPOISOMERASE IV
SUBUNIT B, DNA
TOPOISOMERASE 4
SUBUNIT A CHIMERA

(Streptococcus
pneumoniae) 		PF00204
(DNA_gyraseB)
PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim)
PF02518
(HATPase_c) 		5 ASP A1177
ILE A1178
PRO A1211
ARG A1095
GLY A1166
 None
 1.20A 5k7uA-4i3hA:
undetectable		 5k7uA-4i3hA:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kh3 ANTIGEN 43

(Escherichia
coli) 		PF16168
(AIDA) 		5 ASP A 312
ARG A 310
LEU A 277
ASN A 239
GLY A 260
 None
 1.14A 5k7uA-4kh3A:
undetectable		 5k7uA-4kh3A:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l0y RUNT-RELATED
TRANSCRIPTION FACTOR
1

(Mus musculus) 		PF00853
(Runt) 		5 ILE A 166
LEU A  85
PHE A 136
ARG A 139
ASN A 112
 None
 1.17A 5k7uA-4l0yA:
undetectable		 5k7uA-4l0yA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m8s PUTATIVE
3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE

(Neisseria
meningitidis) 		PF13561
(adh_short_C2) 		5 ILE A 178
ARG A 136
GLU A 172
ARG A 171
GLY A 174
 None
 1.21A 5k7uA-4m8sA:
2.0		 5k7uA-4m8sA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m9x CELL DEATH PROTEIN 4

(Caenorhabditis
elegans) 		PF00619
(CARD)
PF00931
(NB-ARC) 		5 ILE A 323
LEU A 302
GLU A 294
HIS A 136
GLY A 328
 None
 1.36A 5k7uA-4m9xA:
undetectable		 5k7uA-4m9xA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ov6 PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
ADNECTIN

(Homo sapiens;
Homo sapiens) 		PF00082
(Peptidase_S8)
PF00041
(fn3) 		5 ASP B 238
ARG B 194
LYS F  -1
HIS F  85
GLY B 370
 None
 1.35A 5k7uA-4ov6B:
undetectable		 5k7uA-4ov6B:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p4s INTERFERON-INDUCED
GTP-BINDING PROTEIN
MX1

(Homo sapiens) 		PF00350
(Dynamin_N)
PF01031
(Dynamin_M) 		5 ILE A 245
LEU A 327
HIS A 270
ASN A 266
GLY A 244
 None
 1.23A 5k7uA-4p4sA:
undetectable		 5k7uA-4p4sA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q2w PUTATIVE
ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE

(Streptococcus
pneumoniae) 		PF01832
(Glucosaminidase) 		5 ILE A 229
LEU A 162
GLU A 173
PHE A 169
ASN A 179
 None
None
GOL  A 303 ( 4.9A)
None
None
 1.32A 5k7uA-4q2wA:
undetectable		 5k7uA-4q2wA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qbu ZMAA

(Bacillus cereus) 		PF00698
(Acyl_transf_1) 		5 ILE A 358
LEU A 381
PHE A 354
ARG A 353
GLY A 357
 None
 1.30A 5k7uA-4qbuA:
undetectable		 5k7uA-4qbuA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qrj PUTATIVE
6-PHOSPHOGLUCONOLACT
ONASE

(Bacteroides
uniformis) 		PF10282
(Lactonase) 		5 ASP A 357
ILE A 358
PRO A 363
HIS A 274
ASN A 321
 None
 1.25A 5k7uA-4qrjA:
undetectable		 5k7uA-4qrjA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r7y MINICHROMOSOME
MAINTENANCE PROTEIN
MCM, CELL DIVISION
CONTROL PROTEIN 21

(Pyrococcus
furiosus;
Sulfolobus
solfataricus) 		PF00493
(MCM)
PF14551
(MCM_N)
PF17207
(MCM_OB) 		5 ASP A1837
ILE A1836
PRO A1804
PHE A1809
ARG A1811
 None
 1.31A 5k7uA-4r7yA:
undetectable		 5k7uA-4r7yA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u7t DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3A

(Homo sapiens) 		PF00145
(DNA_methylase) 		5 ASP A 686
ARG A 688
PRO A 709
LEU A 730
PHE A 640
 SAH  A1004 (-3.0A)
SAH  A1004 (-4.4A)
SAH  A1004 ( 3.9A)
SAH  A1004 ( 4.9A)
SAH  A1004 (-4.6A)
 0.81A 5k7uA-4u7tA:
undetectable		 5k7uA-4u7tA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4upe NICKEL-DEPENDENT
HYDROGENASE LARGE
SUBUNIT

(Desulfovibrio
fructosivorans) 		PF00374
(NiFeSe_Hases) 		5 ILE Q 178
ARG Q  23
LEU Q 125
PHE Q 179
GLY Q 177
 None
 1.34A 5k7uA-4upeQ:
undetectable		 5k7uA-4upeQ:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zgq CELL DIVISION CYCLE
PROTEIN 123

(Schizosaccharomyces
pombe) 		PF07065
(D123) 		5 ASP A 141
PRO A 154
PHE A 146
HIS A  12
ASN A   8
 None
 1.33A 5k7uA-4zgqA:
undetectable		 5k7uA-4zgqA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a89 RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBF

(Corynebacterium
ammoniagenes) 		PF01687
(Flavokinase) 		5 ILE A 252
GLU A 286
PHE A 287
HIS A 325
GLY A 227
 None
None
None
ZN  A 343 (-3.3A)
None
 1.01A 5k7uA-5a89A:
undetectable		 5k7uA-5a89A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a89 RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBF

(Corynebacterium
ammoniagenes) 		PF01687
(Flavokinase) 		5 ILE A 252
PRO A 220
GLU A 286
PHE A 287
GLY A 227
 None
 1.19A 5k7uA-5a89A:
undetectable		 5k7uA-5a89A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dvj BINDING PROTEIN
COMPONENT OF ABC
SUGAR TRANSPORTER

(Pseudomonas
putida) 		PF01547
(SBP_bac_1) 		5 ILE A 266
PRO A 292
LEU A 169
GLU A 198
PHE A 291
 GOL  A 502 (-3.9A)
None
None
None
None
 1.32A 5k7uA-5dvjA:
undetectable		 5k7uA-5dvjA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eqv BIFUNCTIONAL
2',3'-CYCLIC
NUCLEOTIDE
2'-PHOSPHODIESTERASE
/3'-NUCLEOTIDASE
PERIPLASMIC
PRECURSOR PROTEIN

(Yersinia pestis) 		PF00149
(Metallophos) 		5 ASP A 301
ILE A 329
GLU A 341
HIS A 353
GLY A  59
 None
 1.06A 5k7uA-5eqvA:
undetectable		 5k7uA-5eqvA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ic7 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum) 		no annotation 5 ILE A 338
LEU A 300
PHE A 330
ARG A 285
GLY A 336
 None
 1.32A 5k7uA-5ic7A:
undetectable		 5k7uA-5ic7A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iic MALTOSE-BINDING
PERIPLASMIC
PROTEIN,VITELLINE
ENVELOPE SPERM LYSIN
RECEPTOR

(Escherichia
coli;
Haliotis
rufescens) 		PF11386
(VERL)
PF13416
(SBP_bac_8) 		5 ILE A4317
ARG A4323
LEU A4422
LYS A4011
GLU A4122
 None
None
None
None
MAL  A4501 (-3.8A)
 1.35A 5k7uA-5iicA:
undetectable		 5k7uA-5iicA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikz OXALATE BIOSYNTHETIC
COMPONENT 1

(Burkholderia
thailandensis) 		PF05853
(BKACE) 		5 ASP A 384
ARG A 406
PRO A 453
GLU A 350
HIS A 227
 None
None
None
MG  A1201 (-3.8A)
MG  A1201 (-4.1A)
 1.19A 5k7uA-5ikzA:
undetectable		 5k7uA-5ikzA:
10.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5il0 METTL3

(Homo sapiens) 		PF05063
(MT-A70) 		7 ASP A 377
ILE A 378
ARG A 379
GLU A 532
ARG A 536
ASN A 539
GLY A 548
 None
 0.82A 5k7uA-5il0A:
35.0		 5k7uA-5il0A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5il0 METTL3

(Homo sapiens) 		PF05063
(MT-A70) 		9 ASP A 377
ILE A 378
ARG A 379
PRO A 397
LEU A 409
GLU A 532
PHE A 534
ASN A 539
GLY A 548
 None
 0.39A 5k7uA-5il0A:
35.0		 5k7uA-5il0A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j98 VP3

(Slow bee
paralysis virus) 		PF00073
(Rhv) 		5 ILE C 232
LEU C 145
GLU C 179
PHE C 135
GLY C 136
 None
 1.33A 5k7uA-5j98C:
undetectable		 5k7uA-5j98C:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxk ASP/GLU-SPECIFIC
DIPEPTIDYL-PEPTIDASE

(Porphyromonas
endodontalis) 		PF10459
(Peptidase_S46) 		5 ASP A 126
ILE A 124
PRO A 240
PHE A 195
ARG A 196
 None
 1.26A 5k7uA-5jxkA:
undetectable		 5k7uA-5jxkA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k7m N6-ADENOSINE-METHYLT
RANSFERASE SUBUNIT
METTL14

(Homo sapiens) 		PF05063
(MT-A70) 		6 ASP B 173
ILE B 174
PRO B 194
LYS B 326
PHE B 347
GLY B 361
 None
 0.71A 5k7uA-5k7mB:
21.0		 5k7uA-5k7mB:
25.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kuf GLUTAMATE RECEPTOR
IONOTROPIC, KAINATE
2

(Rattus
norvegicus) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		5 ILE A 789
PRO A 527
LEU A 624
PHE A 524
GLY A 520
 None
 1.14A 5k7uA-5kufA:
undetectable		 5k7uA-5kufA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l6e N6-ADENOSINE-METHYLT
RANSFERASE SUBUNIT
METTL14

(Homo sapiens) 		PF05063
(MT-A70) 		6 ASP B 173
ILE B 174
PRO B 194
LYS B 326
PHE B 347
GLY B 361
 None
 1.19A 5k7uA-5l6eB:
20.0		 5k7uA-5l6eB:
26.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tey N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT

(Homo sapiens) 		PF05063
(MT-A70) 		12 ASP A 377
ILE A 378
ARG A 379
PRO A 397
LEU A 409
LYS A 513
GLU A 532
PHE A 534
ARG A 536
HIS A 538
ASN A 539
GLY A 548
 SAH  A 601 (-3.2A)
SAH  A 601 (-3.9A)
SAH  A 601 ( 4.7A)
SAH  A 601 (-4.3A)
None
SAH  A 601 (-4.9A)
SAH  A 601 ( 4.9A)
SAH  A 601 (-4.7A)
SAH  A 601 (-3.7A)
SAH  A 601 (-4.0A)
SAH  A 601 (-3.1A)
SAH  A 601 ( 3.8A)
 0.42A 5k7uA-5teyA:
32.5		 5k7uA-5teyA:
37.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tey N6-ADENOSINE-METHYLT
RANSFERASE SUBUNIT
METTL14

(Homo sapiens) 		PF05063
(MT-A70) 		6 ASP B 173
ILE B 174
PRO B 194
LYS B 326
PHE B 347
GLY B 361
 None
UNX  B 407 ( 4.2A)
None
None
None
None
 1.16A 5k7uA-5teyB:
19.8		 5k7uA-5teyB:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tu4 PAGF
PRENYLTRANSFERASE

(Planktothrix
agardhii) 		no annotation 5 ILE A  19
LEU A  34
GLU A  51
PHE A  66
HIS A 138
 None
None
B1C  A 403 (-2.9A)
None
B1C  A 403 ( 3.5A)
 1.21A 5k7uA-5tu4A:
undetectable		 5k7uA-5tu4A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ucy TUBULIN ALPHA CHAIN

(Tetrahymena
thermophila) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		5 ILE A  30
PRO A  63
LEU A  86
GLU A  55
ASN A  50
 None
 1.24A 5k7uA-5ucyA:
undetectable		 5k7uA-5ucyA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xnc -

(-) 		no annotation 5 ASP A 206
ARG A 208
PRO A 227
LEU A 342
PHE A 236
 MTA  A 401 (-3.6A)
MTA  A 401 ( 4.3A)
MTA  A 401 (-3.7A)
None
MTA  A 401 (-4.8A)
 1.32A 5k7uA-5xncA:
undetectable		 5k7uA-5xncA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6brr DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3A

(Homo sapiens) 		no annotation 5 ASP A 686
ARG A 688
PRO A 709
LEU A 730
PHE A 640
 SAH  A1001 (-3.0A)
None
SAH  A1001 (-3.7A)
SAH  A1001 (-4.8A)
SAH  A1001 (-4.4A)
 0.73A 5k7uA-6brrA:
undetectable		 5k7uA-6brrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ehs HYDROGENASE-2 LARGE
CHAIN

(Escherichia
coli) 		no annotation 5 ILE L 166
ARG L  12
LEU L 114
PHE L 167
GLY L 165
 None
 1.35A 5k7uA-6ehsL:
undetectable		 5k7uA-6ehsL:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fd5 -

(-) 		no annotation 5 ASP A  65
ILE A  86
ARG A  87
LEU A  92
GLU A 141
 None
 1.04A 5k7uA-6fd5A:
2.2		 5k7uA-6fd5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fdy -

(-) 		no annotation 5 PRO U 237
LEU U 239
PHE U 208
ARG U 107
GLY U 209
 None
 1.08A 5k7uA-6fdyU:
undetectable		 5k7uA-6fdyU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6flz -

(-) 		no annotation 5 ASP A  39
ILE A  38
LEU A  91
GLU A 110
GLY A 108
 MMA  A 201 (-2.7A)
None
None
None
None
 1.31A 5k7uA-6flzA:
undetectable		 5k7uA-6flzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cjy PROTEIN (CYTOSOLIC
PHOSPHOLIPASE A2)

(Homo sapiens) 		PF00168
(C2)
PF01735
(PLA2_B) 		3 ASP A 143
ASN A 497
GLN A  15
 None
 0.68A 5k7uA-1cjyA:
0.8		 5k7uA-1cjyA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f9p CONNECTIVE TISSUE
ACTIVATING
PEPTIDE-III

(Homo sapiens) 		PF00048
(IL8) 		3 ASP A  18
ASN A  52
GLN A  53
 None
 0.82A 5k7uA-1f9pA:
undetectable		 5k7uA-1f9pA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h79 ANAEROBIC
RIBONUCLEOTIDE-TRIPH
OSPHATE REDUCTASE
LARGE CHAIN

(Escherichia
virus T4) 		PF13597
(NRDD) 		3 ASP A 170
ASN A 217
GLN A 176
 None
 0.68A 5k7uA-1h79A:
0.3		 5k7uA-1h79A:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1idu VANADIUM
CHLOROPEROXIDASE

(Curvularia
inaequalis) 		PF01569
(PAP2) 		3 ASP A 456
ASN A 132
GLN A 136
 None
 0.71A 5k7uA-1iduA:
undetectable		 5k7uA-1iduA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jhd SULFATE
ADENYLYLTRANSFERASE

(Sulfur-oxidizing
endosymbiont of
Riftia
pachyptila) 		PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		3 ASP A   8
ASN A 286
GLN A 285
 SO4  A1001 (-3.8A)
None
None
 0.56A 5k7uA-1jhdA:
undetectable		 5k7uA-1jhdA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kwc 2,3-DIHYDROXYBIPHENY
L DIOXYGENASE

(Pseudomonas sp.
KKS102) 		PF00903
(Glyoxalase) 		3 ASP B 243
ASN B 190
GLN B 141
 BPY  B 401 (-3.9A)
None
None
 0.79A 5k7uA-1kwcB:
0.7		 5k7uA-1kwcB:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lkd BIPHENYL-2,3-DIOL
1,2-DIOXYGENASE

(Paraburkholderia
xenovorans) 		PF00903
(Glyoxalase) 		3 ASP A 244
ASN A 191
GLN A 142
 BP6  A 300 ( 4.4A)
None
None
 0.83A 5k7uA-1lkdA:
undetectable		 5k7uA-1lkdA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s70 130 KDA
MYOSIN-BINDING
SUBUNIT OF SMOOTH
MUSCLE MYOSIN
PHOPHATASE (M130)

(Gallus gallus) 		PF12796
(Ank_2) 		3 ASP B 257
ASN B 288
GLN B 284
 None
 0.83A 5k7uA-1s70B:
undetectable		 5k7uA-1s70B:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t4b ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Escherichia
coli) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		3 ASP A 154
ASN A 250
GLN A 246
 None
 0.65A 5k7uA-1t4bA:
undetectable		 5k7uA-1t4bA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v71 HYPOTHETICAL PROTEIN
C320.14 IN
CHROMOSOME III

(Schizosaccharomyces
pombe) 		PF00291
(PALP) 		3 ASP A 228
ASN A 213
GLN A 217
 None
 0.65A 5k7uA-1v71A:
0.2		 5k7uA-1v71A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xdq BACTERIAL SULFITE
OXIDASE

(Escherichia
coli) 		PF00174
(Oxidored_molyb) 		3 ASP A  38
ASN A  44
GLN A 188
 None
MTE  A 301 (-4.0A)
None
 0.83A 5k7uA-1xdqA:
undetectable		 5k7uA-1xdqA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xvt CROTONOBETAINYL-COA:
CARNITINE
COA-TRANSFERASE

(Escherichia
coli) 		PF02515
(CoA_transf_3) 		3 ASP A 230
ASN A 154
GLN A 153
 None
 0.81A 5k7uA-1xvtA:
undetectable		 5k7uA-1xvtA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z68 FIBROBLAST
ACTIVATION PROTEIN,
ALPHA SUBUNIT

(Homo sapiens) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		3 ASP A 478
ASN A  80
GLN A  65
 None
 0.71A 5k7uA-1z68A:
undetectable		 5k7uA-1z68A:
14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2adc POLYPYRIMIDINE
TRACT-BINDING
PROTEIN 1

(Homo sapiens) 		PF00076
(RRM_1)
PF13893
(RRM_5) 		3 ASP A 383
ASN A 413
GLN A 412
 None
 0.77A 5k7uA-2adcA:
undetectable		 5k7uA-2adcA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bxy MALTOOLIGOSYLTREHALO
SE TREHALOHYDROLASE

(Deinococcus
radiodurans) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48)
PF11941
(DUF3459) 		3 ASP A 329
ASN A 398
GLN A 401
 None
BME  A1608 (-4.3A)
None
 0.75A 5k7uA-2bxyA:
undetectable		 5k7uA-2bxyA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d4y FLAGELLAR
HOOK-ASSOCIATED
PROTEIN 1

(Salmonella
enterica) 		no annotation 3 ASP A 180
ASN A 225
GLN A 219
 None
 0.77A 5k7uA-2d4yA:
undetectable		 5k7uA-2d4yA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2et6 (3R)-HYDROXYACYL-COA
DEHYDROGENASE

(Candida
tropicalis) 		PF00106
(adh_short) 		3 ASP A 279
ASN A 586
GLN A 553
 None
 0.65A 5k7uA-2et6A:
undetectable		 5k7uA-2et6A:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i6t UBIQUITIN-CONJUGATIN
G ENZYME E2-LIKE
ISOFORM A

(Homo sapiens) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		3 ASP A 399
ASN A 320
GLN A 324
 None
 0.81A 5k7uA-2i6tA:
undetectable		 5k7uA-2i6tA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iik 3-KETOACYL-COA
THIOLASE,
PEROXISOMAL

(Homo sapiens) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		3 ASP A 281
ASN A  90
GLN A  93
 None
 0.63A 5k7uA-2iikA:
undetectable		 5k7uA-2iikA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j04 HYPOTHETICAL PROTEIN
YPL007C

(Saccharomyces
cerevisiae) 		PF12660
(zf-TFIIIC) 		3 ASP A  70
ASN A 105
GLN A  83
 None
 0.78A 5k7uA-2j04A:
undetectable		 5k7uA-2j04A:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jfe CYTOSOLIC
BETA-GLUCOSIDASE

(Homo sapiens) 		PF00232
(Glyco_hydro_1) 		3 ASP X 302
ASN X 410
GLN X 412
 None
 0.79A 5k7uA-2jfeX:
undetectable		 5k7uA-2jfeX:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ox8 SCAVENGER RECEPTOR
WITH C-TYPE LECTIN
TYPE I

(Homo sapiens) 		PF00059
(Lectin_C) 		3 ASP A 707
ASN A 718
GLN A 694
 ZN  A   4 (-2.8A)
None
None
 0.73A 5k7uA-2ox8A:
undetectable		 5k7uA-2ox8A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pi5 DNA-DIRECTED RNA
POLYMERASE

(Escherichia
virus T7) 		PF00940
(RNA_pol)
PF14700
(RPOL_N) 		3 ASP A 770
ASN A 762
GLN A 744
 None
 0.70A 5k7uA-2pi5A:
undetectable		 5k7uA-2pi5A:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qmx PREPHENATE
DEHYDRATASE

(Chlorobaculum
tepidum) 		PF00800
(PDT) 		3 ASP A  34
ASN A  62
GLN A  61
 None
 0.79A 5k7uA-2qmxA:
undetectable		 5k7uA-2qmxA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rem DISULFIDE
OXIDOREDUCTASE

(Xylella
fastidiosa) 		PF13462
(Thioredoxin_4) 		3 ASP A  73
ASN A 109
GLN A 108
 None
 0.80A 5k7uA-2remA:
undetectable		 5k7uA-2remA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v24 SPRY
DOMAIN-CONTAINING
SOCS BOX PROTEIN 4

(Homo sapiens) 		PF00622
(SPRY) 		3 ASP A 193
ASN A 103
GLN A 101
 None
 0.76A 5k7uA-2v24A:
undetectable		 5k7uA-2v24A:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v6u PTERIN-4A-CARBINOLAM
INE DEHYDRATASE

(Toxoplasma
gondii) 		PF01329
(Pterin_4a) 		3 ASP A  73
ASN A  70
GLN A  38
 None
 0.72A 5k7uA-2v6uA:
undetectable		 5k7uA-2v6uA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yk0 ERYTHROCYTE MEMBRANE
PROTEIN 1

(Plasmodium
falciparum) 		PF03011
(PFEMP)
PF05424
(Duffy_binding)
PF15447
(NTS) 		3 ASP A 353
ASN A 362
GLN A 363
 None
 0.66A 5k7uA-2yk0A:
undetectable		 5k7uA-2yk0A:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bkh LYTIC
TRANSGLYCOSYLASE

(Pseudomonas
virus phiKZ) 		PF01464
(SLT)
PF01471
(PG_binding_1) 		3 ASP A 195
ASN A 249
GLN A 245
 None
 0.83A 5k7uA-3bkhA:
undetectable		 5k7uA-3bkhA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3czc RMPB

(Streptococcus
mutans) 		PF02302
(PTS_IIB) 		3 ASP A  80
ASN A  24
GLN A  28
 None
 0.81A 5k7uA-3czcA:
undetectable		 5k7uA-3czcA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dqq PUTATIVE TRNA
SYNTHASE

(Salmonella
enterica) 		PF07005
(DUF1537)
PF17042
(DUF1357_C) 		3 ASP A   9
ASN A  32
GLN A  30
 None
 0.76A 5k7uA-3dqqA:
undetectable		 5k7uA-3dqqA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fqd PROTEIN DIN1

(Schizosaccharomyces
pombe) 		PF08652
(RAI1) 		3 ASP B 118
ASN B  87
GLN B  85
 None
 0.82A 5k7uA-3fqdB:
undetectable		 5k7uA-3fqdB:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gbw E3 UBIQUITIN-PROTEIN
LIGASE MYCBP2

(Mus musculus) 		PF08005
(PHR) 		3 ASP A1343
ASN A1235
GLN A1381
 None
 0.78A 5k7uA-3gbwA:
undetectable		 5k7uA-3gbwA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i0m DNA REPAIR AND
TELOMERE MAINTENANCE
PROTEIN NBS1

(Schizosaccharomyces
pombe) 		PF00498
(FHA) 		3 ASP A  74
ASN A  89
GLN A  88
 None
 0.83A 5k7uA-3i0mA:
undetectable		 5k7uA-3i0mA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3igz COFACTOR-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Leishmania
mexicana) 		PF01676
(Metalloenzyme)
PF06415
(iPGM_N) 		3 ASP B 170
ASN B 391
GLN B 389
 None
 0.70A 5k7uA-3igzB:
undetectable		 5k7uA-3igzB:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ldf PUTATIVE
UNCHARACTERIZED
PROTEIN SMU.776

(Streptococcus
mutans) 		PF10672
(Methyltrans_SAM) 		3 ASP A 372
ASN A 101
GLN A 102
 None
 0.48A 5k7uA-3ldfA:
undetectable		 5k7uA-3ldfA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m07 PUTATIVE ALPHA
AMYLASE

(Salmonella
enterica) 		PF00128
(Alpha-amylase)
PF11941
(DUF3459) 		3 ASP A 323
ASN A 391
GLN A 394
 None
 0.82A 5k7uA-3m07A:
undetectable		 5k7uA-3m07A:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mg3 ORANGE
CAROTENOID-BINDING
PROTEIN

(Synechocystis
sp. PCC 6803) 		PF02136
(NTF2)
PF09150
(Carot_N) 		3 ASP A 209
ASN A 247
GLN A 246
 None
 0.73A 5k7uA-3mg3A:
undetectable		 5k7uA-3mg3A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mwn PHYCOERYTHRIN

(Phormidium
tenue) 		PF00502
(Phycobilisome) 		3 ASP A1057
ASN A1080
GLN A1076
 None
 0.79A 5k7uA-3mwnA:
undetectable		 5k7uA-3mwnA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oo9 ABC TRANSPORTER
BINDING PROTEIN ACBH

(Actinoplanes
sp. SE50/110) 		PF01547
(SBP_bac_1) 		3 ASP A 286
ASN A 254
GLN A 255
 None
None
GOL  A 414 (-3.8A)
 0.80A 5k7uA-3oo9A:
undetectable		 5k7uA-3oo9A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opw DNA
DAMAGE-RESPONSIVE
TRANSCRIPTIONAL
REPRESSOR RPH1

(Saccharomyces
cerevisiae) 		PF02373
(JmjC)
PF02375
(JmjN) 		3 ASP A 186
ASN A  89
GLN A  76
 None
 0.76A 5k7uA-3opwA:
undetectable		 5k7uA-3opwA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pc3 CG1753, ISOFORM A

(Drosophila
melanogaster) 		PF00291
(PALP)
PF00571
(CBS) 		3 ASP A  89
ASN A 197
GLN A 191
 None
P1T  A 702 ( 4.7A)
P1T  A 702 (-2.9A)
 0.78A 5k7uA-3pc3A:
undetectable		 5k7uA-3pc3A:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pqh GENE PRODUCT 138

(unidentified
phage) 		no annotation 3 ASP A 169
ASN A 173
GLN A 188
 None
 0.79A 5k7uA-3pqhA:
undetectable		 5k7uA-3pqhA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pqi GENE PRODUCT 138

(unidentified
phage) 		no annotation 3 ASP A 169
ASN A 173
GLN A 188
 None
 0.81A 5k7uA-3pqiA:
undetectable		 5k7uA-3pqiA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s51 FANCONI ANEMIA GROUP
I PROTEIN HOMOLOG

(Mus musculus) 		PF14674
(FANCI_S1-cap)
PF14675
(FANCI_S1)
PF14676
(FANCI_S2)
PF14677
(FANCI_S3)
PF14678
(FANCI_S4)
PF14679
(FANCI_HD1)
PF14680
(FANCI_HD2) 		3 ASP A 610
ASN A 545
GLN A 503
 None
 0.80A 5k7uA-3s51A:
undetectable		 5k7uA-3s51A:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3syj ADHESION AND
PENETRATION PROTEIN
AUTOTRANSPORTER

(Haemophilus
influenzae) 		PF02395
(Peptidase_S6)
PF03212
(Pertactin) 		3 ASP A 487
ASN A 530
GLN A 533
 None
 0.78A 5k7uA-3syjA:
undetectable		 5k7uA-3syjA:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wme ATP-BINDING
CASSETTE, SUB-FAMILY
B, MEMBER 1

(Cyanidioschyzon
merolae) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		3 ASP A 402
ASN A 244
GLN A 395
 None
 0.80A 5k7uA-3wmeA:
undetectable		 5k7uA-3wmeA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4akm LYSOSOME-ASSOCIATED
MEMBRANE
GLYCOPROTEIN 3

(Homo sapiens) 		PF01299
(Lamp) 		3 ASP A 357
ASN A 262
GLN A 245
 None
 0.75A 5k7uA-4akmA:
undetectable		 5k7uA-4akmA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4amc GLUCANSUCRASE

(Lactobacillus
reuteri) 		PF01473
(CW_binding_1)
PF02324
(Glyco_hydro_70) 		3 ASP A1165
ASN A1179
GLN A1171
 None
 0.71A 5k7uA-4amcA:
undetectable		 5k7uA-4amcA:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bq4 B-AGARASE

(Saccharophagus
degradans) 		PF02449
(Glyco_hydro_42) 		3 ASP A 755
ASN A 533
GLN A 534
 None
GAL  A1795 ( 3.3A)
AAL  A1796 ( 3.1A)
 0.78A 5k7uA-4bq4A:
undetectable		 5k7uA-4bq4A:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0e NOT1

(Chaetomium
thermophilum) 		PF04054
(Not1) 		3 ASP A2065
ASN A2110
GLN A2114
 None
 0.77A 5k7uA-4c0eA:
undetectable		 5k7uA-4c0eA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dnx SULFATE
ADENYLYLTRANSFERASE

(Allochromatium
vinosum) 		PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		3 ASP A   8
ASN A 286
GLN A 285
 None
 0.64A 5k7uA-4dnxA:
1.0		 5k7uA-4dnxA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ew9 PECTATE LYASE

(Caldicellulosiruptor
bescii) 		PF03211
(Pectate_lyase) 		3 ASP A 162
ASN A 113
GLN A 111
 None
DGU  A 210 (-3.4A)
UNG  A 209 ( 3.4A)
 0.69A 5k7uA-4ew9A:
undetectable		 5k7uA-4ew9A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fgv CHROMOSOME REGION
MAINTENANCE 1 (CRM1)
OR EXPORTIN 1 (XPO1)

(Chaetomium
thermophilum) 		PF03810
(IBN_N)
PF08389
(Xpo1)
PF08767
(CRM1_C) 		3 ASP A 713
ASN A 692
GLN A 706
 None
 0.59A 5k7uA-4fgvA:
undetectable		 5k7uA-4fgvA:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gk5 DNA REPAIR PROTEIN
REV1

(Homo sapiens) 		PF16727
(REV1_C) 		3 ASP E1234
ASN E1226
GLN E1218
 None
 0.82A 5k7uA-4gk5E:
undetectable		 5k7uA-4gk5E:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gkl ALPHA-AMYLASE

(Thermotoga
neapolitana) 		PF00128
(Alpha-amylase) 		3 ASP A 214
ASN A 255
GLN A 258
 None
 0.77A 5k7uA-4gklA:
undetectable		 5k7uA-4gklA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i62 AMINO ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING
PROTEIN, PUTATIVE

(Streptococcus
pneumoniae) 		PF00497
(SBP_bac_3) 		3 ASP A 166
ASN A 129
GLN A 160
 None
None
ARG  A 301 (-3.7A)
 0.68A 5k7uA-4i62A:
undetectable		 5k7uA-4i62A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4im9 DNA PRIMASE

(Vibrio cholerae) 		PF08278
(DnaG_DnaB_bind) 		3 ASP A  16
ASN A  24
GLN A  94
 None
 0.80A 5k7uA-4im9A:
undetectable		 5k7uA-4im9A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ka8 OLIGOPEPTIDASE A

(Arabidopsis
thaliana) 		PF01432
(Peptidase_M3) 		3 ASP A 496
ASN A 750
GLN A 746
 None
 0.76A 5k7uA-4ka8A:
undetectable		 5k7uA-4ka8A:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l27 CYSTATHIONINE
BETA-SYNTHASE

(Homo sapiens) 		no annotation 3 ASP B 120
ASN B 228
GLN B 222
 None
PLP  B 601 ( 4.9A)
None
 0.64A 5k7uA-4l27B:
undetectable		 5k7uA-4l27B:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l9a PUTATIVE
UNCHARACTERIZED
PROTEIN SMU.1393C

(Streptococcus
mutans) 		no annotation 3 ASP A 207
ASN A 112
GLN A 113
 None
 0.80A 5k7uA-4l9aA:
2.0		 5k7uA-4l9aA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lor COMPLEMENT C1S
SUBCOMPONENT HEAVY
CHAIN

(Homo sapiens) 		PF00431
(CUB)
PF14670
(FXa_inhibition) 		3 ASP A  43
ASN A  12
GLN A  15
 None
 0.83A 5k7uA-4lorA:
undetectable		 5k7uA-4lorA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qlb PROBABLE GLYCOGEN
[STARCH] SYNTHASE

(Caenorhabditis
elegans) 		PF05693
(Glycogen_syn) 		3 ASP A  24
ASN A 621
GLN A 620
 None
 0.73A 5k7uA-4qlbA:
undetectable		 5k7uA-4qlbA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r04 TOXIN A

(Clostridioides
difficile) 		PF11713
(Peptidase_C80)
PF12918
(TcdB_N)
PF12919
(TcdA_TcdB)
PF12920
(TcdA_TcdB_pore) 		3 ASP A 590
ASN A 613
GLN A 611
 None
 0.74A 5k7uA-4r04A:
undetectable		 5k7uA-4r04A:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4sli INTRAMOLECULAR
TRANS-SIALIDASE

(Macrobdella
decora) 		PF02973
(Sialidase)
PF13088
(BNR_2) 		3 ASP A 732
ASN A 155
GLN A 708
 None
 0.79A 5k7uA-4sliA:
undetectable		 5k7uA-4sliA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tqx SORTASE

(Streptococcus
mutans) 		PF04203
(Sortase) 		3 ASP A 100
ASN A 104
GLN A 239
 None
 0.80A 5k7uA-4tqxA:
undetectable		 5k7uA-4tqxA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v3q YIII_M4_AII

(synthetic
construct) 		PF00514
(Arm)
PF16186
(Arm_3) 		3 ASP A  24
ASN A  66
GLN A  68
 None
 0.79A 5k7uA-4v3qA:
undetectable		 5k7uA-4v3qA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wd9 NISIN BIOSYNTHESIS
PROTEIN NISB

(Lactococcus
lactis) 		PF04738
(Lant_dehydr_N)
PF14028
(Lant_dehydr_C) 		3 ASP A 607
ASN A 325
GLN A 419
 None
 0.83A 5k7uA-4wd9A:
undetectable		 5k7uA-4wd9A:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wy4 VESICLE-ASSOCIATED
MEMBRANE PROTEIN 8
SYNAPTOSOMAL-ASSOCIA
TED PROTEIN 29

(Homo sapiens;
Homo sapiens) 		PF00957
(Synaptobrevin)
no annotation 		3 ASP D 218
ASN A  30
GLN D 224
 None
 0.76A 5k7uA-4wy4D:
undetectable		 5k7uA-4wy4D:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xb0 SERINE/THREONINE-PRO
TEIN KINASE PLK2

(Homo sapiens) 		PF00659
(POLO_box) 		3 ASP A 585
ASN A 624
GLN A 622
 None
 0.78A 5k7uA-4xb0A:
undetectable		 5k7uA-4xb0A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z3y BENZOYL-COA
REDUCTASE, PUTATIVE

(Geobacter
metallireducens) 		PF01314
(AFOR_C)
PF02730
(AFOR_N) 		3 ASP A 352
ASN A 426
GLN A 433
 MTE  A 703 (-3.7A)
None
None
 0.81A 5k7uA-4z3yA:
undetectable		 5k7uA-4z3yA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5awf PROBABLE
ATP-DEPENDENT
TRANSPORTER SUFC

(Escherichia
coli) 		PF00005
(ABC_tran) 		3 ASP C 119
ASN C 104
GLN C 100
 None
 0.77A 5k7uA-5awfC:
1.5		 5k7uA-5awfC:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cnx AMINOPEPTIDASE YPDF

(Escherichia
coli) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		3 ASP A 301
ASN A  26
GLN A  25
 None
 0.82A 5k7uA-5cnxA:
undetectable		 5k7uA-5cnxA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hgr ORANGE CAROTENOID
PROTEIN (OCP)

(Nostoc sp. PCC
7120) 		PF02136
(NTF2)
PF09150
(Carot_N) 		3 ASP A 211
ASN A 249
GLN A 248
 None
 0.77A 5k7uA-5hgrA:
undetectable		 5k7uA-5hgrA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hmq 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE

(Pseudomonas
putida) 		PF00903
(Glyoxalase)
PF01261
(AP_endonuc_2)
PF14696
(Glyoxalase_5) 		3 ASP A 109
ASN A 150
GLN A 154
 None
 0.77A 5k7uA-5hmqA:
undetectable		 5k7uA-5hmqA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i4k MANGANESE-BINDING
LIPOPROTEIN MNTA

(Listeria
monocytogenes) 		PF01297
(ZnuA) 		3 ASP A 194
ASN A 198
GLN A 199
 None
 0.76A 5k7uA-5i4kA:
undetectable		 5k7uA-5i4kA:
19.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5il0 METTL3

(Homo sapiens) 		PF05063
(MT-A70) 		3 ASP A 395
ASN A 549
GLN A 550
 None
 0.39A 5k7uA-5il0A:
35.0		 5k7uA-5il0A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k3h ACYL-COENZYME A
OXIDASE

(Caenorhabditis
elegans) 		PF01756
(ACOX)
PF02770
(Acyl-CoA_dh_M)
PF14749
(Acyl-CoA_ox_N) 		3 ASP A 565
ASN A 572
GLN A 599
 None
 0.73A 5k7uA-5k3hA:
undetectable		 5k7uA-5k3hA:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k3j ACYL-COENZYME A
OXIDASE

(Caenorhabditis
elegans) 		PF01756
(ACOX)
PF02770
(Acyl-CoA_dh_M)
PF14749
(Acyl-CoA_ox_N) 		3 ASP A 557
ASN A 564
GLN A 589
 None
 0.76A 5k7uA-5k3jA:
undetectable		 5k7uA-5k3jA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lgx PENTAERYTHRITOL
TETRANITRATE
REDUCTASE

(Enterobacter
cloacae) 		PF00724
(Oxidored_FMN) 		3 ASP A 144
ASN A 242
GLN A 241
 None
 0.76A 5k7uA-5lgxA:
undetectable		 5k7uA-5lgxA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m11 IMMUNOREACTIVE 84KD
ANTIGEN PG93

(Porphyromonas
gingivalis) 		no annotation 3 ASP A 610
ASN A 653
GLN A 624
 GOL  A 817 (-3.1A)
None
None
 0.77A 5k7uA-5m11A:
undetectable		 5k7uA-5m11A:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mg5 HYDROXYMETHYLGLUTARY
L-COA SYNTHASE

(Pseudomonas
protegens) 		no annotation 3 ASP A  33
ASN A  27
GLN A  23
 None
 0.61A 5k7uA-5mg5A:
undetectable		 5k7uA-5mg5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n9v NAD(P)(+)--ARGININE
ADP-RIBOSYLTRANSFERA
SE

(Tetrahymena
thermophila) 		no annotation 3 ASP A  60
ASN A  54
GLN A  55
 None
 0.82A 5k7uA-5n9vA:
undetectable		 5k7uA-5n9vA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oc1 ARYL-ALCOHOL OXIDASE

(Pleurotus
eryngii) 		no annotation 3 ASP A 470
ASN A 325
GLN A 326
 None
 0.65A 5k7uA-5oc1A:
undetectable		 5k7uA-5oc1A:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ohx CYSTATHIONINE
BETA-SYNTHASE

(Apis mellifera) 		no annotation 3 ASP A  79
ASN A 187
GLN A 181
 None
PLP  A 702 ( 4.1A)
None
 0.73A 5k7uA-5ohxA:
undetectable		 5k7uA-5ohxA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tey N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT

(Homo sapiens) 		PF05063
(MT-A70) 		3 ASP A 395
ASN A 549
GLN A 550
 SAH  A 601 (-3.8A)
SAH  A 601 (-3.1A)
SAH  A 601 (-3.7A)
 0.14A 5k7uA-5teyA:
32.5		 5k7uA-5teyA:
37.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tj3 ALKALINE PHOSPHATASE
PAFA

(Elizabethkingia
meningoseptica) 		PF01663
(Phosphodiest) 		3 ASP A 320
ASN A 225
GLN A 226
 None
 0.61A 5k7uA-5tj3A:
1.4		 5k7uA-5tj3A:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tj7 NEDD4-LIKE E3
UBIQUITIN-PROTEIN
LIGASE WWP2

(Homo sapiens) 		PF00397
(WW)
PF00632
(HECT) 		3 ASP A 600
ASN A 534
GLN A 530
 None
 0.63A 5k7uA-5tj7A:
undetectable		 5k7uA-5tj7A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ui2 ORANGE
CAROTENOID-BINDING
PROTEIN

(Arthrospira
maxima) 		PF02136
(NTF2)
PF09150
(Carot_N) 		3 ASP A 211
ASN A 249
GLN A 248
 None
SUC  A 401 (-3.6A)
None
 0.80A 5k7uA-5ui2A:
undetectable		 5k7uA-5ui2A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wi8 TUMOR NECROSIS
FACTOR RECEPTOR
SUPERFAMILY MEMBER 9

(Mus musculus) 		no annotation 3 ASP A 104
ASN A 125
GLN A 127
 None
 0.80A 5k7uA-5wi8A:
undetectable		 5k7uA-5wi8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wq8 TYPE II SECRETION
SYSTEM PROTEIN D

(Vibrio cholerae) 		PF00263
(Secretin)
PF03958
(Secretin_N) 		3 ASP A 631
ASN A 601
GLN A 597
 None
 0.75A 5k7uA-5wq8A:
undetectable		 5k7uA-5wq8A:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
TRANSCRIPTION
ELONGATION FACTOR 1
HOMOLOG

(Komagataella
phaffii;
Komagataella
pastoris) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4)
PF05129
(Elf1) 		3 ASP A 178
ASN M  32
GLN M  22
 None
 0.78A 5k7uA-5xogA:
undetectable		 5k7uA-5xogA:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yfp EXOCYST COMPLEX
COMPONENT EXO84

(Saccharomyces
cerevisiae) 		no annotation 3 ASP H 696
ASN H 638
GLN H 634
 None
 0.75A 5k7uA-5yfpH:
undetectable		 5k7uA-5yfpH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z5c CYSTEINE SYNTHASE

(Fusobacterium
nucleatum) 		no annotation 3 ASP A  47
ASN A 153
GLN A 147
 None
PLP  A 401 ( 4.7A)
CL  A 402 (-3.5A)
 0.75A 5k7uA-5z5cA:
undetectable		 5k7uA-5z5cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b4h NUCLEOPORIN GLE1

(Chaetomium
thermophilum) 		no annotation 3 ASP A 523
ASN A 475
GLN A 474
 None
 0.50A 5k7uA-6b4hA:
undetectable		 5k7uA-6b4hA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c2h CYSTATHIONINE
BETA-SYNTHASE

(Saccharomyces
cerevisiae) 		no annotation 3 ASP A  54
ASN A 163
GLN A 157
 None
PLP  A 401 ( 4.8A)
ACT  A 402 (-3.0A)
 0.75A 5k7uA-6c2hA:
undetectable		 5k7uA-6c2hA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c66 CRISPR-ASSOCIATED
PROTEIN, CSE4 FAMILY

(Thermobifida
fusca) 		no annotation 3 ASP B 345
ASN B 320
GLN B 316
 None
 0.83A 5k7uA-6c66B:
undetectable		 5k7uA-6c66B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cwx RIBONUCLEASE P
PROTEIN SUBUNIT P20

(Homo sapiens) 		no annotation 3 ASP A  44
ASN A  83
GLN A  87
 None
FMT  A 201 (-3.9A)
None
 0.62A 5k7uA-6cwxA:
2.8		 5k7uA-6cwxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6v TELOMERASE
HOLOENZYME TEB
HETEROTRIMER TEB3
SUBUNIT

(Tetrahymena
thermophila) 		no annotation 3 ASP F  57
ASN F  79
GLN F  80
 None
 0.45A 5k7uA-6d6vF:
undetectable		 5k7uA-6d6vF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gh2 LAMINARIBIOSE
PHOSPHORYLASE

(Paenibacillus
sp. YM1) 		no annotation 3 ASP A 432
ASN A 504
GLN A 503
 None
 0.82A 5k7uA-6gh2A:
undetectable		 5k7uA-6gh2A:
undetectable