SIMILAR PATTERNS OF AMINO ACIDS FOR 5JWA_A_ACTA613

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p87 PRE-MRNA-SPLICING
FACTOR PRP8

(Caenorhabditis
elegans) 		PF01398
(JAB)
PF08084
(PROCT) 		4 ASP A2200
LYS A2203
THR A2204
PRO A2167
 None
 1.39A 5jwaA-2p87A:
0.0		 5jwaA-2p87A:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v1u LYND

(Lyngbya
aestuarii) 		PF02624
(YcaO) 		4 ASP A 299
LYS A 301
THR A 292
PRO A 361
 None
 1.16A 5jwaA-4v1uA:
0.0		 5jwaA-4v1uA:
20.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jwb TYPE II
NADH:UBIQUINONE
OXIDOREDUCTASE

(Plasmodium
falciparum) 		PF07992
(Pyr_redox_2) 		4 ASP A 520
LYS A 523
THR A 524
PRO A 530
 ACT  A 612 (-3.3A)
ACT  A 612 (-3.7A)
ACT  A 612 (-4.5A)
None
 0.21A 5jwaA-5jwbA:
56.9		 5jwaA-5jwbA:
100.00