SIMILAR PATTERNS OF AMINO ACIDS FOR 5JW1_B_CELB602_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6v METHYL-COENZYME M
REDUCTASE I ALPHA
SUBUNIT

(Methanopyrus
kandleri) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N) 		5 ALA A 246
VAL A 148
GLY A 146
ALA A 142
LEU A 143
 F43  A1553 (-3.6A)
F43  A1553 (-3.6A)
None
None
None
 1.03A 5jw1B-1e6vA:
0.0		 5jw1B-1e6vA:
18.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ebv PROSTAGLANDIN H2
SYNTHASE

(Ovis aries) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		8 ARG A 120
GLN A 192
LEU A 352
TYR A 355
LEU A 359
TRP A 387
GLY A 526
ALA A 527
 SCL  A 700 (-3.9A)
None
SCL  A 700 ( 4.8A)
SCL  A 700 (-4.3A)
None
None
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
 0.84A 5jw1B-1ebvA:
57.4		 5jw1B-1ebvA:
64.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ebv PROSTAGLANDIN H2
SYNTHASE

(Ovis aries) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		9 HIS A  90
GLN A 192
LEU A 352
TYR A 355
LEU A 359
TRP A 387
GLY A 526
ALA A 527
LEU A 531
 None
None
SCL  A 700 ( 4.8A)
SCL  A 700 (-4.3A)
None
None
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
OAS  A 530 (-4.1A)
 0.36A 5jw1B-1ebvA:
57.4		 5jw1B-1ebvA:
64.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hyg L-LACTATE/MALATE
DEHYDROGENASE

(Methanocaldococcus
jannaschii) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 LEU A  19
LEU A  29
ALA A 235
VAL A  12
LEU A  44
 None
None
None
NAP  A 900 (-4.3A)
None
 1.09A 5jw1B-1hygA:
0.4		 5jw1B-1hygA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mzj BETA-KETOACYLSYNTHAS
E III

(Streptomyces
sp. R1128) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 LEU A 128
LEU A 117
VAL A 186
GLY A 326
ALA A 325
 None
 0.98A 5jw1B-1mzjA:
0.0		 5jw1B-1mzjA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n61 CARBON MONOXIDE
DEHYDROGENASE MEDIUM
CHAIN

(Oligotropha
carboxidovorans) 		PF00941
(FAD_binding_5)
PF03450
(CO_deh_flav_C) 		5 LEU C  21
ALA C  46
GLY C  33
ALA C  32
LEU C  54
 None
None
FAD  C3932 (-3.4A)
FAD  C3932 (-3.5A)
None
 1.03A 5jw1B-1n61C:
0.0		 5jw1B-1n61C:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n61 CARBON MONOXIDE
DEHYDROGENASE MEDIUM
CHAIN

(Oligotropha
carboxidovorans) 		PF00941
(FAD_binding_5)
PF03450
(CO_deh_flav_C) 		5 LEU C  51
LEU C  21
ALA C  46
GLY C  33
ALA C  32
 None
None
None
FAD  C3932 (-3.4A)
FAD  C3932 (-3.5A)
 1.00A 5jw1B-1n61C:
0.0		 5jw1B-1n61C:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sc6 D-3-PHOSPHOGLYCERATE
DEHYDROGENASE

(Escherichia
coli) 		PF00389
(2-Hacid_dh)
PF01842
(ACT)
PF02826
(2-Hacid_dh_C) 		5 LEU A  65
ALA A  93
VAL A 101
GLY A  80
ALA A  81
 None
 0.92A 5jw1B-1sc6A:
undetectable		 5jw1B-1sc6A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1thg LIPASE 2

(Galactomyces
candidus) 		PF00135
(COesterase) 		5 LEU A  91
ALA A 218
GLY A 355
ALA A 357
LEU A 459
 None
 1.07A 5jw1B-1thgA:
0.0		 5jw1B-1thgA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vc9 NDX1

(Thermus
thermophilus) 		PF00293
(NUDIX) 		5 LEU A  58
ALA A 120
VAL A   9
GLY A  83
ALA A  55
 None
 1.09A 5jw1B-1vc9A:
undetectable		 5jw1B-1vc9A:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vhn PUTATIVE FLAVIN
OXIDOREDUCTASE

(Thermotoga
maritima) 		PF01207
(Dus) 		5 LEU A  73
ALA A  62
GLY A  92
ALA A  91
LEU A 107
 None
None
SO4  A 319 (-3.6A)
None
None
 1.10A 5jw1B-1vhnA:
0.0		 5jw1B-1vhnA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vyv CALCIUM CHANNEL
BETA-4SUBUNIT

(Rattus
norvegicus) 		PF00625
(Guanylate_kin)
PF12052
(VGCC_beta4Aa_N) 		5 LEU A 305
LEU A 307
ALA A  95
VAL A 141
ALA A 400
 None
 1.09A 5jw1B-1vyvA:
undetectable		 5jw1B-1vyvA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x3l HYPOTHETICAL PROTEIN
PH0495

(Pyrococcus
horikoshii) 		PF05161
(MOFRL)
PF13660
(DUF4147) 		5 LEU A 107
LEU A 146
ALA A 112
VAL A  79
ALA A  96
 None
 1.06A 5jw1B-1x3lA:
undetectable		 5jw1B-1x3lA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yoa PUTATIVE
FLAVOPROTEIN

(Thermus
thermophilus) 		PF01613
(Flavin_Reduct) 		5 LEU A 106
LEU A 116
ALA A  29
VAL A  60
GLY A  64
 None
None
FAD  A 401 (-3.1A)
None
None
 0.98A 5jw1B-1yoaA:
undetectable		 5jw1B-1yoaA:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cxn GLUCOSE-6-PHOSPHATE
ISOMERASE

(Mus musculus) 		PF00342
(PGI) 		5 ARG A 104
LEU A 490
ALA A 170
GLY A 299
ALA A 300
 None
 0.90A 5jw1B-2cxnA:
undetectable		 5jw1B-2cxnA:
25.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dws COPPER-CONTAINING
NITRITE REDUCTASE

(Rhodobacter
sphaeroides) 		PF00394
(Cu-oxidase)
PF07732
(Cu-oxidase_3) 		5 HIS A  60
TYR A 204
LEU A 324
ALA A  57
GLY A 161
 None
 0.93A 5jw1B-2dwsA:
undetectable		 5jw1B-2dwsA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ebd 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Aquifex
aeolicus) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 LEU A  97
ALA A 117
VAL A 163
GLY A   7
ALA A  61
 None
 1.07A 5jw1B-2ebdA:
undetectable		 5jw1B-2ebdA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE

(Pseudomonas
aeruginosa) 		PF00682
(HMGL-like) 		5 LEU A 297
ALA A  40
VAL A 234
GLY A 236
ALA A 235
 None
 1.08A 5jw1B-2ftpA:
undetectable		 5jw1B-2ftpA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gfp MULTIDRUG RESISTANCE
PROTEIN D

(Escherichia
coli) 		PF07690
(MFS_1) 		6 LEU A 136
ALA A 307
VAL A 115
GLY A 114
ALA A 117
LEU A  13
 None
 1.49A 5jw1B-2gfpA:
undetectable		 5jw1B-2gfpA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hfs MEVALONATE KINASE,
PUTATIVE

(Leishmania
major) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		5 LEU A 242
ALA A 289
VAL A  19
ALA A  36
LEU A 164
 None
 1.03A 5jw1B-2hfsA:
undetectable		 5jw1B-2hfsA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2inp PHENOL HYDROXYLASE
COMPONENT PHL

(Pseudomonas
stutzeri) 		PF02332
(Phenol_Hydrox) 		5 ARG C 160
ALA C 296
VAL C 129
GLY C 132
ALA C 133
 None
 0.87A 5jw1B-2inpC:
undetectable		 5jw1B-2inpC:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k4k GENERAL STRESS
PROTEIN 13

(Bacillus
subtilis) 		PF00575
(S1) 		5 ALA A  78
VAL A  35
GLY A  22
ALA A  23
LEU A  18
 None
 0.93A 5jw1B-2k4kA:
undetectable		 5jw1B-2k4kA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o5r GLUTAMYL-TRNA
SYNTHETASE 1

(Thermotoga
maritima) 		PF00749
(tRNA-synt_1c) 		5 ALA A 257
VAL A  16
GLY A  18
ALA A  19
LEU A  65
 None
 1.08A 5jw1B-2o5rA:
undetectable		 5jw1B-2o5rA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r94 2-KETO-3-DEOXY-(6-PH
OSPHO-)GLUCONATE
ALDOLASE

(Thermoproteus
tenax) 		PF00701
(DHDPS) 		5 LEU A  36
ALA A  84
GLY A  60
ALA A  59
LEU A  68
 None
None
PYR  A 999 (-3.0A)
None
None
 1.07A 5jw1B-2r94A:
0.5		 5jw1B-2r94A:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rdc UNCHARACTERIZED
PROTEIN

(Geobacter
sulfurreducens) 		PF11554
(DUF3232) 		5 ARG A  52
LEU A  98
TRP A 138
GLY A  50
ALA A  49
 None
 1.00A 5jw1B-2rdcA:
undetectable		 5jw1B-2rdcA:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wjv REGULATOR OF
NONSENSE TRANSCRIPTS
1

(Homo sapiens) 		PF04851
(ResIII)
PF09416
(UPF1_Zn_bind)
PF13086
(AAA_11)
PF13087
(AAA_12) 		5 LEU A 518
LEU A 509
VAL A 650
GLY A 653
ALA A 654
 None
 1.09A 5jw1B-2wjvA:
undetectable		 5jw1B-2wjvA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wjv REGULATOR OF
NONSENSE TRANSCRIPTS
1

(Homo sapiens) 		PF04851
(ResIII)
PF09416
(UPF1_Zn_bind)
PF13086
(AAA_11)
PF13087
(AAA_12) 		5 LEU A 659
ALA A 299
VAL A 437
GLY A 653
ALA A 654
 None
 0.89A 5jw1B-2wjvA:
undetectable		 5jw1B-2wjvA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wsx L-CARNITINE/GAMMA-BU
TYROBETAINE
ANTIPORTER

(Escherichia
coli) 		PF02028
(BCCT) 		5 LEU A  79
ALA A 148
VAL A  70
GLY A  72
ALA A  75
 None
 1.02A 5jw1B-2wsxA:
undetectable		 5jw1B-2wsxA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xgt ASPARAGINYL-TRNA
SYNTHETASE,
CYTOPLASMIC

(Brugia malayi) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		5 ALA A 223
VAL A 235
GLY A 238
ALA A 241
LEU A 244
 None
 1.02A 5jw1B-2xgtA:
undetectable		 5jw1B-2xgtA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xzo REGULATOR OF
NONSENSE TRANSCRIPTS
1

(Homo sapiens) 		PF04851
(ResIII)
PF13086
(AAA_11)
PF13087
(AAA_12) 		5 LEU A 659
ALA A 299
VAL A 437
GLY A 653
ALA A 654
 None
 1.04A 5jw1B-2xzoA:
undetectable		 5jw1B-2xzoA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yr5 PRO-ENZYME OF
L-PHENYLALANINE
OXIDASE

(Pseudomonas sp.
P-501) 		no annotation 5 ALA A 236
VAL A 214
GLY A 211
ALA A 210
LEU A 206
 None
 0.98A 5jw1B-2yr5A:
undetectable		 5jw1B-2yr5A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ywd GLUTAMINE
AMIDOTRANSFERASE
SUBUNIT PDXT

(Thermus
thermophilus) 		PF01174
(SNO) 		5 LEU A 160
LEU A 144
GLY A  79
ALA A  84
LEU A 103
 None
 1.09A 5jw1B-2ywdA:
undetectable		 5jw1B-2ywdA:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a71 EXO-ARABINANASE

(Penicillium
chrysogenum) 		no annotation 5 LEU A 108
ALA A 340
GLY A 127
ALA A 126
LEU A 141
 None
 1.08A 5jw1B-3a71A:
undetectable		 5jw1B-3a71A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3at7 ALGINATE-BINDING
FLAGELLIN

(Sphingomonas
sp. A1) 		PF09375
(Peptidase_M75) 		5 LEU A  87
VAL A 158
GLY A 160
ALA A 162
LEU A 165
 None
 1.07A 5jw1B-3at7A:
undetectable		 5jw1B-3at7A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gdn R-OXYNITRILE LYASE
ISOENZYME 1

(Prunus dulcis) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 TYR A 457
ALA A 495
VAL A 113
GLY A 112
ALA A 111
 HBX  A 530 (-4.3A)
None
FAD  A 522 (-3.7A)
FAD  A 522 (-3.9A)
FAD  A 522 ( 3.0A)
 0.96A 5jw1B-3gdnA:
undetectable		 5jw1B-3gdnA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gxo MMCR

(Streptomyces
lavendulae) 		PF00891
(Methyltransf_2) 		5 LEU A 224
ALA A 186
GLY A 172
ALA A 171
LEU A 168
 None
 1.05A 5jw1B-3gxoA:
undetectable		 5jw1B-3gxoA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hdi PROCESSING PROTEASE

(Bacillus
halodurans) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		5 LEU A 400
LEU A 142
ALA A 410
GLY A 301
ALA A 300
 None
 1.05A 5jw1B-3hdiA:
undetectable		 5jw1B-3hdiA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjb GLUCOSE-6-PHOSPHATE
ISOMERASE

(Vibrio cholerae) 		PF00342
(PGI) 		5 ARG A 103
LEU A 486
ALA A 169
GLY A 297
ALA A 298
 None
 0.93A 5jw1B-3hjbA:
undetectable		 5jw1B-3hjbA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i83 2-DEHYDROPANTOATE
2-REDUCTASE

(Methylococcus
capsulatus) 		PF02558
(ApbA)
PF08546
(ApbA_C) 		5 GLN A 264
VAL A  80
GLY A  82
ALA A  83
LEU A  88
 None
 1.04A 5jw1B-3i83A:
undetectable		 5jw1B-3i83A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iwa FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE

(Desulfovibrio
vulgaris) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 HIS A  96
TYR A 113
GLY A 266
ALA A 265
LEU A 261
 None
 1.02A 5jw1B-3iwaA:
undetectable		 5jw1B-3iwaA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k1l FANCL

(Drosophila
melanogaster) 		no annotation 5 GLN B 211
LEU B 378
LEU B 343
GLY B 252
LEU B 371
 None
 1.08A 5jw1B-3k1lB:
undetectable		 5jw1B-3k1lB:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kc2 UNCHARACTERIZED
PROTEIN YKR070W

(Saccharomyces
cerevisiae) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		5 LEU A  50
ALA A 210
GLY A  33
ALA A  34
LEU A  38
 None
 1.08A 5jw1B-3kc2A:
undetectable		 5jw1B-3kc2A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l4d STEROL 14-ALPHA
DEMETHYLASE

(Leishmania
infantum) 		PF00067
(p450) 		5 LEU A 260
LEU A 187
VAL A 280
GLY A 282
LEU A 235
 None
 1.07A 5jw1B-3l4dA:
undetectable		 5jw1B-3l4dA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lvv GLUTAMATE--CYSTEINE
LIGASE

(Saccharomyces
cerevisiae) 		PF03074
(GCS) 		5 LEU A 186
ALA A 308
VAL A 316
GLY A 319
ALA A 320
 None
 0.91A 5jw1B-3lvvA:
undetectable		 5jw1B-3lvvA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n29 CARBOXYNORSPERMIDINE
DECARBOXYLASE

(Campylobacter
jejuni) 		PF00278
(Orn_DAP_Arg_deC) 		5 LEU A  56
ALA A  34
GLY A 235
ALA A  39
LEU A  40
 None
None
PLP  A1001 (-3.3A)
PLP  A1001 (-3.3A)
None
 1.02A 5jw1B-3n29A:
undetectable		 5jw1B-3n29A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r0z D-SERINE DEHYDRATASE

(Salmonella
enterica) 		PF00291
(PALP) 		5 LEU A  42
LEU A  37
ALA A  50
GLY A 283
LEU A 354
 None
 0.98A 5jw1B-3r0zA:
0.2		 5jw1B-3r0zA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r5g CYAB

(Pseudomonas
aeruginosa) 		PF00211
(Guanylate_cyc) 		5 LEU A 228
TYR A 336
GLY A 291
ALA A 292
LEU A 381
 None
 1.10A 5jw1B-3r5gA:
undetectable		 5jw1B-3r5gA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3skd PUTATIVE
UNCHARACTERIZED
PROTEIN TTHB187

(Thermus
thermophilus) 		no annotation 5 LEU A  59
LEU A 176
VAL A  35
ALA A  34
LEU A 230
 None
 0.93A 5jw1B-3skdA:
undetectable		 5jw1B-3skdA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3slk POLYKETIDE SYNTHASE
EXTENDER MODULE 2

(Saccharopolyspora
spinosa) 		PF08240
(ADH_N)
PF08659
(KR)
PF13602
(ADH_zinc_N_2) 		5 LEU A 663
ALA A 658
VAL A 622
GLY A 624
LEU A 629
 None
 0.92A 5jw1B-3slkA:
undetectable		 5jw1B-3slkA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sqg METHYL COENZYME M
REDUCTASE, ALPHA
SUBUNIT

(uncultured
archaeon) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N) 		5 ALA A 257
VAL A 153
GLY A 151
ALA A 147
LEU A 148
 M43  A1001 (-3.4A)
M43  A1001 (-3.5A)
None
None
None
 1.02A 5jw1B-3sqgA:
undetectable		 5jw1B-3sqgA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ss7 D-SERINE DEHYDRATASE

(Escherichia
coli) 		PF00291
(PALP) 		5 LEU X  44
LEU X  39
ALA X  52
GLY X 285
LEU X 356
 None
 0.93A 5jw1B-3ss7X:
0.0		 5jw1B-3ss7X:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tox SHORT CHAIN
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF13561
(adh_short_C2) 		5 LEU A 232
LEU A 187
ALA A  33
GLY A 238
ALA A 239
 None
 1.03A 5jw1B-3toxA:
undetectable		 5jw1B-3toxA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ugv ENOLASE

(alpha
proteobacterium
BAL199) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 LEU A 352
ALA A 117
GLY A 310
ALA A 311
LEU A 344
 None
 1.09A 5jw1B-3ugvA:
undetectable		 5jw1B-3ugvA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zz1 BETA-D-GLUCOSIDE
GLUCOHYDROLASE

(Trichoderma
reesei) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 LEU A 334
LEU A 341
VAL A 480
GLY A 504
ALA A 503
 None
 1.01A 5jw1B-3zz1A:
undetectable		 5jw1B-3zz1A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a5a NUCLEOSIDE-TRIPHOSPH
ATASE 1

(Toxoplasma
gondii) 		PF01150
(GDA1_CD39) 		5 ARG A 388
LEU A 357
ALA A 496
ALA A 333
LEU A 337
 None
None
ANP  A 700 (-3.5A)
None
None
 0.93A 5jw1B-4a5aA:
undetectable		 5jw1B-4a5aA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a6e HYDROXYINDOLE
O-METHYLTRANSFERASE

(Homo sapiens) 		PF00891
(Methyltransf_2)
PF16864
(Dimerisation2) 		5 HIS A 264
LEU A 250
GLY A 325
ALA A 324
LEU A 321
 None
 1.06A 5jw1B-4a6eA:
undetectable		 5jw1B-4a6eA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4em6 GLUCOSE-6-PHOSPHATE
ISOMERASE

(Brucella
melitensis) 		no annotation 5 ARG D   3
LEU D 317
VAL D  74
ALA D  72
LEU D   8
 None
 0.95A 5jw1B-4em6D:
undetectable		 5jw1B-4em6D:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g3j STEROL
14-ALPHA-DEMETHYLASE

(Trypanosoma
brucei) 		PF00067
(p450) 		5 LEU A 261
LEU A 188
VAL A 281
GLY A 283
LEU A 236
 None
 1.01A 5jw1B-4g3jA:
undetectable		 5jw1B-4g3jA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hqn SPOROZOITE SURFACE
PROTEIN 2

(Plasmodium
vivax) 		PF00090
(TSP_1)
PF00092
(VWA) 		5 LEU A 168
LEU A 133
GLY A 200
ALA A 199
LEU A 181
 None
 1.07A 5jw1B-4hqnA:
undetectable		 5jw1B-4hqnA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4idm DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF00171
(Aldedh) 		5 HIS A 262
ALA A 201
VAL A 183
GLY A 181
ALA A 259
 None
 1.08A 5jw1B-4idmA:
0.5		 5jw1B-4idmA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jb1 UDP-N-ACETYLENOLPYRU
VOYLGLUCOSAMINE
REDUCTASE

(Pseudomonas
aeruginosa) 		PF01565
(FAD_binding_4)
PF02873
(MurB_C) 		5 TYR A 165
LEU A 245
ALA A 131
GLY A 276
ALA A 275
 None
None
NAP  A 402 ( 3.3A)
None
None
 0.98A 5jw1B-4jb1A:
undetectable		 5jw1B-4jb1A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mdy PERIPLASMIC BINDING
PROTEIN

(Mycolicibacterium
smegmatis) 		PF01497
(Peripla_BP_2) 		5 LEU A  66
ALA A 166
GLY A  59
ALA A  58
LEU A 103
 None
 1.08A 5jw1B-4mdyA:
undetectable		 5jw1B-4mdyA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mfz DBV8 PROTEIN

(Nonomuraea
gerenzanensis) 		no annotation 5 TYR A 209
LEU A 204
ALA A 216
GLY A 234
LEU A 238
 None
MFK  A 401 (-4.6A)
None
MFK  A 401 ( 3.9A)
MFK  A 401 (-4.6A)
 0.86A 5jw1B-4mfzA:
undetectable		 5jw1B-4mfzA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nng 30S RIBOSOMAL
PROTEIN S1

(Mycobacterium
tuberculosis) 		PF00575
(S1) 		5 ALA A 365
VAL A 321
GLY A 308
ALA A 309
LEU A 304
 None
 0.99A 5jw1B-4nngA:
undetectable		 5jw1B-4nngA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o1m ENOYL-ACYL CARRIER
REDUCTASE

(Toxoplasma
gondii) 		PF13561
(adh_short_C2) 		5 LEU A 286
VAL A 266
GLY A 268
ALA A 270
LEU A 274
 None
 0.80A 5jw1B-4o1mA:
undetectable		 5jw1B-4o1mA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p9k TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Verminephrobacter
eiseniae) 		PF03480
(DctP) 		5 ARG A 278
GLN A 264
LEU A 139
GLY A 273
ALA A 274
 None
 0.94A 5jw1B-4p9kA:
undetectable		 5jw1B-4p9kA:
18.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ph9 PROSTAGLANDIN G/H
SYNTHASE 2

(Mus musculus) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		11 HIS A  90
ARG A 121
GLN A 193
LEU A 353
TYR A 356
LEU A 360
TRP A 388
ALA A 517
VAL A 524
GLY A 527
ALA A 528
 None
BOG  A 604 ( 3.7A)
None
IBP  A 601 ( 4.7A)
IBP  A 601 (-4.5A)
IBP  A 601 ( 4.7A)
None
None
IBP  A 601 ( 4.0A)
IBP  A 601 (-3.9A)
IBP  A 601 (-3.4A)
 0.76A 5jw1B-4ph9A:
62.7		 5jw1B-4ph9A:
99.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ph9 PROSTAGLANDIN G/H
SYNTHASE 2

(Mus musculus) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		11 HIS A  90
GLN A 193
LEU A 353
TYR A 356
LEU A 360
TRP A 388
ALA A 517
VAL A 524
GLY A 527
ALA A 528
LEU A 532
 None
None
IBP  A 601 ( 4.7A)
IBP  A 601 (-4.5A)
IBP  A 601 ( 4.7A)
None
None
IBP  A 601 ( 4.0A)
IBP  A 601 (-3.9A)
IBP  A 601 (-3.4A)
IBP  A 601 ( 4.9A)
 0.35A 5jw1B-4ph9A:
62.7		 5jw1B-4ph9A:
99.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r1d UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		no annotation 5 HIS A 279
LEU A 418
TYR A 423
ALA A 262
GLY A 286
 None
 1.00A 5jw1B-4r1dA:
undetectable		 5jw1B-4r1dA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rnc ESTERASE

(Rhodococcus sp.
ECU1013) 		PF12697
(Abhydrolase_6) 		5 LEU A 209
ALA A  95
VAL A  82
GLY A  80
ALA A  79
 None
 1.02A 5jw1B-4rncA:
undetectable		 5jw1B-4rncA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tqv ALGM1
ALGM2

(Sphingomonas
sp.) 		PF00528
(BPD_transp_1) 		5 LEU B 232
TYR B 213
VAL B 237
GLY A 150
ALA A 149
 None
 1.06A 5jw1B-4tqvB:
undetectable		 5jw1B-4tqvB:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wmj GLUCOSE-6-PHOSPHATE
ISOMERASE

(Colias
eurytheme) 		PF00342
(PGI) 		5 ARG A 108
LEU A 493
ALA A 174
GLY A 302
ALA A 303
 None
 0.98A 5jw1B-4wmjA:
undetectable		 5jw1B-4wmjA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xwu INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE

(Eremothecium
gossypii) 		PF00478
(IMPDH) 		5 ARG A 111
LEU A 263
ALA A 252
GLY A 270
ALA A 269
 None
 0.89A 5jw1B-4xwuA:
undetectable		 5jw1B-4xwuA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z19 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Yersinia pestis) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 LEU A  98
ALA A 122
VAL A 164
GLY A   7
ALA A  62
 None
 1.02A 5jw1B-4z19A:
undetectable		 5jw1B-4z19A:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ziu UNCHARACTERIZED
LIPOPROTEIN YFHM

(Escherichia
coli) 		PF07678
(A2M_comp) 		5 LEU A1401
ALA A1313
GLY A1340
ALA A1366
LEU A1367
 None
 1.02A 5jw1B-4ziuA:
undetectable		 5jw1B-4ziuA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8r METHYL-COENZYME M
REDUCTASE II SUBUNIT
ALPHA

(Methanothermobacter
marburgensis) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N) 		5 ALA A 246
VAL A 148
GLY A 146
ALA A 142
LEU A 143
 F43  A 603 (-3.3A)
F43  A 603 (-3.5A)
None
None
None
 1.10A 5jw1B-5a8rA:
undetectable		 5jw1B-5a8rA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5co4 PUTATIVE TRNA
(CYTIDINE(34)-2'-O)-
METHYLTRANSFERASE

(Thermus
thermophilus) 		no annotation 6 LEU B  98
LEU B 107
ALA B  90
GLY B 136
ALA B 134
LEU B 131
 None
None
None
None
MTA  B 401 (-3.5A)
MTA  B 401 ( 4.2A)
 1.30A 5jw1B-5co4B:
undetectable		 5jw1B-5co4B:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL

(Homo sapiens) 		PF00117
(GATase)
PF00988
(CPSase_sm_chain)
PF02142
(MGS)
PF02786
(CPSase_L_D2)
PF02787
(CPSase_L_D3) 		5 GLN A 375
LEU A 290
GLY A 305
ALA A 304
LEU A 282
 None
 1.05A 5jw1B-5dotA:
undetectable		 5jw1B-5dotA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dxi TREHALOSE-6-PHOSPHAT
E PHOSPHATASE

(Candida
albicans) 		PF02358
(Trehalose_PPase) 		5 LEU A  11
LEU A 226
GLY A 296
ALA A 295
LEU A  53
 None
 1.01A 5jw1B-5dxiA:
undetectable		 5jw1B-5dxiA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e24 SUPPRESSOR OF
HAIRLESS PROTEIN

(Drosophila
melanogaster) 		PF09270
(BTD)
PF09271
(LAG1-DNAbind) 		5 LEU E 125
LEU E 215
ALA E 262
ALA E 198
LEU E 189
 EDO  E 604 (-4.9A)
None
None
EDO  E 623 ( 3.9A)
None
 1.03A 5jw1B-5e24E:
undetectable		 5jw1B-5e24E:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fbz ENZYME SUBTILASE
SUBHAL FROM BACILLUS
HALMAPALUS

(Bacillus
halmapalus) 		PF00082
(Peptidase_S8)
PF04151
(PPC) 		5 ALA A 158
VAL A  72
GLY A  74
ALA A  73
LEU A  91
 None
None
5VV  A   1 ( 4.8A)
None
None
 0.94A 5jw1B-5fbzA:
undetectable		 5jw1B-5fbzA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ffn ENZYME SUBTILASE
SUBTY FROM BACILLUS
SP. TY145

(Bacillus sp.
(in: Bacteria)) 		PF00082
(Peptidase_S8) 		5 ALA A 167
VAL A  76
GLY A  78
ALA A  77
LEU A 100
 None
 1.02A 5jw1B-5ffnA:
undetectable		 5jw1B-5ffnA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h5z MHC CLASS I ANTIGEN

(Ctenopharyngodon
idella) 		no annotation 5 GLN A 152
TYR A  97
VAL A  65
GLY A  68
ALA A  69
 None
 1.07A 5jw1B-5h5zA:
undetectable		 5jw1B-5h5zA:
10.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ikr PROSTAGLANDIN G/H
SYNTHASE 2

(Homo sapiens) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		9 HIS A  90
ARG A 120
GLN A 192
TYR A 355
LEU A 359
TRP A 387
ALA A 516
GLY A 526
ALA A 527
 None
ID8  A 601 ( 4.4A)
None
ID8  A 601 (-3.8A)
None
COH  A 602 (-4.5A)
None
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
 0.82A 5jw1B-5ikrA:
61.1		 5jw1B-5ikrA:
87.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ikr PROSTAGLANDIN G/H
SYNTHASE 2

(Homo sapiens) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		11 HIS A  90
GLN A 192
LEU A 352
TYR A 355
LEU A 359
TRP A 387
ALA A 516
VAL A 523
GLY A 526
ALA A 527
LEU A 531
 None
None
ID8  A 601 (-4.1A)
ID8  A 601 (-3.8A)
None
COH  A 602 (-4.5A)
None
ID8  A 601 (-3.6A)
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
 0.49A 5jw1B-5ikrA:
61.1		 5jw1B-5ikrA:
87.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kei 2,3-DIHYDROXYBENZOAT
E-AMP LIGASE

(Mycolicibacterium
smegmatis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 LEU A 266
ALA A 106
GLY A 273
ALA A 274
LEU A 243
 None
 1.01A 5jw1B-5keiA:
undetectable		 5jw1B-5keiA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m32 PROTEASOME SUBUNIT
BETA TYPE-2

(Homo sapiens) 		PF00227
(Proteasome) 		5 LEU J   4
TYR J 117
GLY J 135
ALA J 136
LEU J 140
 None
 1.08A 5jw1B-5m32J:
undetectable		 5jw1B-5m32J:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mhk RS1

(Human
alphaherpesvirus
1) 		PF03584
(Herpes_ICP4_N) 		5 LEU A 432
LEU A 328
ALA A 446
GLY A 439
ALA A 438
 None
 1.07A 5jw1B-5mhkA:
undetectable		 5jw1B-5mhkA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n6m APOLIPOPROTEIN
N-ACYLTRANSFERASE

(Pseudomonas
aeruginosa) 		PF00795
(CN_hydrolase) 		5 LEU A  21
LEU A  26
ALA A  40
GLY A  64
ALA A  65
 None
 1.06A 5jw1B-5n6mA:
1.4		 5jw1B-5n6mA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tc3 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Eremothecium
gossypii) 		PF00478
(IMPDH)
PF00571
(CBS) 		5 ARG A 111
LEU A 263
ALA A 252
GLY A 270
ALA A 269
 None
 0.90A 5jw1B-5tc3A:
undetectable		 5jw1B-5tc3A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tkw TYPE II SECRETION
SYSTEM PROTEIN L

(Klebsiella
pneumoniae) 		PF05134
(T2SSL) 		5 LEU A  52
LEU A 135
ALA A  29
GLY A  39
LEU A  23
 None
 1.08A 5jw1B-5tkwA:
undetectable		 5jw1B-5tkwA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u4h UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Acinetobacter
baumannii) 		PF00275
(EPSP_synthase) 		5 LEU A 240
LEU A 379
VAL A  16
GLY A  14
LEU A  12
 None
 1.09A 5jw1B-5u4hA:
undetectable		 5jw1B-5u4hA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ug1 ACYLTRANSFERASE

(Streptococcus
pneumoniae) 		no annotation 5 LEU A 515
LEU A 434
ALA A 535
ALA A 593
LEU A 594
 None
 1.06A 5jw1B-5ug1A:
undetectable		 5jw1B-5ug1A:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uld TRANSPORTER, NADC
FAMILY

(Vibrio cholerae) 		PF00939
(Na_sulph_symp) 		5 LEU A 270
VAL A 295
GLY A 298
ALA A 299
LEU A 303
 None
 0.79A 5jw1B-5uldA:
undetectable		 5jw1B-5uldA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v2m MEVALONATE
DIPHOSPHATE
DECARBOXYLASE

(Enterococcus
faecalis) 		no annotation 5 LEU A 121
LEU A 133
VAL A  46
GLY A   4
ALA A 116
 None
 1.06A 5jw1B-5v2mA:
undetectable		 5jw1B-5v2mA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wu6 SPECKLE TARGETED
PIP5K1A-REGULATED
POLY(A) POLYMERASE

(Homo sapiens) 		PF00076
(RRM_1)
PF03828
(PAP_assoc) 		6 LEU A 422
LEU A 437
VAL A 559
GLY A 561
ALA A 560
LEU A 507
 None
 1.31A 5jw1B-5wu6A:
undetectable		 5jw1B-5wu6A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y09 PROTEASE DO-LIKE 9

(Arabidopsis
thaliana) 		no annotation 5 ALA A 565
VAL A 540
GLY A 538
ALA A 537
LEU A 586
 None
 1.09A 5jw1B-5y09A:
undetectable		 5jw1B-5y09A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yvs ALCOHOL
DEHYDROGENASE

(candidate
divison MSBL1
archaeon
SCGC-AAA259E19) 		no annotation 5 ALA A 160
VAL A  77
GLY A  80
ALA A  81
LEU A  85
 None
 0.68A 5jw1B-5yvsA:
undetectable		 5jw1B-5yvsA:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bac ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Neisseria
gonorrhoeae) 		no annotation 5 LEU A 147
LEU A 253
ALA A 345
GLY A 298
ALA A 299
 None
 0.87A 5jw1B-6bacA:
undetectable		 5jw1B-6bacA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6byq TYROSINE--TRNA
LIGASE

(Helicobacter
pylori) 		no annotation 5 LEU A  76
LEU A  63
TRP A 130
GLY A 186
ALA A 187
 None
 0.98A 5jw1B-6byqA:
undetectable		 5jw1B-6byqA:
9.28