SIMILAR PATTERNS OF AMINO ACIDS FOR 5JW1_B_CELB602

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6v METHYL-COENZYME M
REDUCTASE I ALPHA
SUBUNIT

(Methanopyrus
kandleri) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N) 		5 ALA A 246
VAL A 148
GLY A 146
ALA A 142
LEU A 143
 F43  A1553 (-3.6A)
F43  A1553 (-3.6A)
None
None
None
 1.03A 5jw1B-1e6vA:
0.0		 5jw1B-1e6vA:
18.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ebv PROSTAGLANDIN H2
SYNTHASE

(Ovis aries) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		8 ARG A 120
GLN A 192
LEU A 352
TYR A 355
LEU A 359
TRP A 387
GLY A 526
ALA A 527
 SCL  A 700 (-3.9A)
None
SCL  A 700 ( 4.8A)
SCL  A 700 (-4.3A)
None
None
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
 0.84A 5jw1B-1ebvA:
57.4		 5jw1B-1ebvA:
64.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ebv PROSTAGLANDIN H2
SYNTHASE

(Ovis aries) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		9 HIS A  90
GLN A 192
LEU A 352
TYR A 355
LEU A 359
TRP A 387
GLY A 526
ALA A 527
LEU A 531
 None
None
SCL  A 700 ( 4.8A)
SCL  A 700 (-4.3A)
None
None
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
OAS  A 530 (-4.1A)
 0.36A 5jw1B-1ebvA:
57.4		 5jw1B-1ebvA:
64.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hyg L-LACTATE/MALATE
DEHYDROGENASE

(Methanocaldococcus
jannaschii) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 LEU A  19
LEU A  29
ALA A 235
VAL A  12
LEU A  44
 None
None
None
NAP  A 900 (-4.3A)
None
 1.09A 5jw1B-1hygA:
0.4		 5jw1B-1hygA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mzj BETA-KETOACYLSYNTHAS
E III

(Streptomyces
sp. R1128) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 LEU A 128
LEU A 117
VAL A 186
GLY A 326
ALA A 325
 None
 0.98A 5jw1B-1mzjA:
0.0		 5jw1B-1mzjA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n61 CARBON MONOXIDE
DEHYDROGENASE MEDIUM
CHAIN

(Oligotropha
carboxidovorans) 		PF00941
(FAD_binding_5)
PF03450
(CO_deh_flav_C) 		5 LEU C  21
ALA C  46
GLY C  33
ALA C  32
LEU C  54
 None
None
FAD  C3932 (-3.4A)
FAD  C3932 (-3.5A)
None
 1.03A 5jw1B-1n61C:
0.0		 5jw1B-1n61C:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n61 CARBON MONOXIDE
DEHYDROGENASE MEDIUM
CHAIN

(Oligotropha
carboxidovorans) 		PF00941
(FAD_binding_5)
PF03450
(CO_deh_flav_C) 		5 LEU C  51
LEU C  21
ALA C  46
GLY C  33
ALA C  32
 None
None
None
FAD  C3932 (-3.4A)
FAD  C3932 (-3.5A)
 1.00A 5jw1B-1n61C:
0.0		 5jw1B-1n61C:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sc6 D-3-PHOSPHOGLYCERATE
DEHYDROGENASE

(Escherichia
coli) 		PF00389
(2-Hacid_dh)
PF01842
(ACT)
PF02826
(2-Hacid_dh_C) 		5 LEU A  65
ALA A  93
VAL A 101
GLY A  80
ALA A  81
 None
 0.92A 5jw1B-1sc6A:
undetectable		 5jw1B-1sc6A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1thg LIPASE 2

(Galactomyces
candidus) 		PF00135
(COesterase) 		5 LEU A  91
ALA A 218
GLY A 355
ALA A 357
LEU A 459
 None
 1.07A 5jw1B-1thgA:
0.0		 5jw1B-1thgA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vc9 NDX1

(Thermus
thermophilus) 		PF00293
(NUDIX) 		5 LEU A  58
ALA A 120
VAL A   9
GLY A  83
ALA A  55
 None
 1.09A 5jw1B-1vc9A:
undetectable		 5jw1B-1vc9A:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vhn PUTATIVE FLAVIN
OXIDOREDUCTASE

(Thermotoga
maritima) 		PF01207
(Dus) 		5 LEU A  73
ALA A  62
GLY A  92
ALA A  91
LEU A 107
 None
None
SO4  A 319 (-3.6A)
None
None
 1.10A 5jw1B-1vhnA:
0.0		 5jw1B-1vhnA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vyv CALCIUM CHANNEL
BETA-4SUBUNIT

(Rattus
norvegicus) 		PF00625
(Guanylate_kin)
PF12052
(VGCC_beta4Aa_N) 		5 LEU A 305
LEU A 307
ALA A  95
VAL A 141
ALA A 400
 None
 1.09A 5jw1B-1vyvA:
undetectable		 5jw1B-1vyvA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x3l HYPOTHETICAL PROTEIN
PH0495

(Pyrococcus
horikoshii) 		PF05161
(MOFRL)
PF13660
(DUF4147) 		5 LEU A 107
LEU A 146
ALA A 112
VAL A  79
ALA A  96
 None
 1.06A 5jw1B-1x3lA:
undetectable		 5jw1B-1x3lA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yoa PUTATIVE
FLAVOPROTEIN

(Thermus
thermophilus) 		PF01613
(Flavin_Reduct) 		5 LEU A 106
LEU A 116
ALA A  29
VAL A  60
GLY A  64
 None
None
FAD  A 401 (-3.1A)
None
None
 0.98A 5jw1B-1yoaA:
undetectable		 5jw1B-1yoaA:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cxn GLUCOSE-6-PHOSPHATE
ISOMERASE

(Mus musculus) 		PF00342
(PGI) 		5 ARG A 104
LEU A 490
ALA A 170
GLY A 299
ALA A 300
 None
 0.90A 5jw1B-2cxnA:
undetectable		 5jw1B-2cxnA:
25.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dws COPPER-CONTAINING
NITRITE REDUCTASE

(Rhodobacter
sphaeroides) 		PF00394
(Cu-oxidase)
PF07732
(Cu-oxidase_3) 		5 HIS A  60
TYR A 204
LEU A 324
ALA A  57
GLY A 161
 None
 0.93A 5jw1B-2dwsA:
undetectable		 5jw1B-2dwsA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ebd 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Aquifex
aeolicus) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 LEU A  97
ALA A 117
VAL A 163
GLY A   7
ALA A  61
 None
 1.07A 5jw1B-2ebdA:
undetectable		 5jw1B-2ebdA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE

(Pseudomonas
aeruginosa) 		PF00682
(HMGL-like) 		5 LEU A 297
ALA A  40
VAL A 234
GLY A 236
ALA A 235
 None
 1.08A 5jw1B-2ftpA:
undetectable		 5jw1B-2ftpA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gfp MULTIDRUG RESISTANCE
PROTEIN D

(Escherichia
coli) 		PF07690
(MFS_1) 		6 LEU A 136
ALA A 307
VAL A 115
GLY A 114
ALA A 117
LEU A  13
 None
 1.49A 5jw1B-2gfpA:
undetectable		 5jw1B-2gfpA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hfs MEVALONATE KINASE,
PUTATIVE

(Leishmania
major) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		5 LEU A 242
ALA A 289
VAL A  19
ALA A  36
LEU A 164
 None
 1.03A 5jw1B-2hfsA:
undetectable		 5jw1B-2hfsA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2inp PHENOL HYDROXYLASE
COMPONENT PHL

(Pseudomonas
stutzeri) 		PF02332
(Phenol_Hydrox) 		5 ARG C 160
ALA C 296
VAL C 129
GLY C 132
ALA C 133
 None
 0.87A 5jw1B-2inpC:
undetectable		 5jw1B-2inpC:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k4k GENERAL STRESS
PROTEIN 13

(Bacillus
subtilis) 		PF00575
(S1) 		5 ALA A  78
VAL A  35
GLY A  22
ALA A  23
LEU A  18
 None
 0.93A 5jw1B-2k4kA:
undetectable		 5jw1B-2k4kA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o5r GLUTAMYL-TRNA
SYNTHETASE 1

(Thermotoga
maritima) 		PF00749
(tRNA-synt_1c) 		5 ALA A 257
VAL A  16
GLY A  18
ALA A  19
LEU A  65
 None
 1.08A 5jw1B-2o5rA:
undetectable		 5jw1B-2o5rA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r94 2-KETO-3-DEOXY-(6-PH
OSPHO-)GLUCONATE
ALDOLASE

(Thermoproteus
tenax) 		PF00701
(DHDPS) 		5 LEU A  36
ALA A  84
GLY A  60
ALA A  59
LEU A  68
 None
None
PYR  A 999 (-3.0A)
None
None
 1.07A 5jw1B-2r94A:
0.5		 5jw1B-2r94A:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rdc UNCHARACTERIZED
PROTEIN

(Geobacter
sulfurreducens) 		PF11554
(DUF3232) 		5 ARG A  52
LEU A  98
TRP A 138
GLY A  50
ALA A  49
 None
 1.00A 5jw1B-2rdcA:
undetectable		 5jw1B-2rdcA:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wjv REGULATOR OF
NONSENSE TRANSCRIPTS
1

(Homo sapiens) 		PF04851
(ResIII)
PF09416
(UPF1_Zn_bind)
PF13086
(AAA_11)
PF13087
(AAA_12) 		5 LEU A 518
LEU A 509
VAL A 650
GLY A 653
ALA A 654
 None
 1.09A 5jw1B-2wjvA:
undetectable		 5jw1B-2wjvA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wjv REGULATOR OF
NONSENSE TRANSCRIPTS
1

(Homo sapiens) 		PF04851
(ResIII)
PF09416
(UPF1_Zn_bind)
PF13086
(AAA_11)
PF13087
(AAA_12) 		5 LEU A 659
ALA A 299
VAL A 437
GLY A 653
ALA A 654
 None
 0.89A 5jw1B-2wjvA:
undetectable		 5jw1B-2wjvA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wsx L-CARNITINE/GAMMA-BU
TYROBETAINE
ANTIPORTER

(Escherichia
coli) 		PF02028
(BCCT) 		5 LEU A  79
ALA A 148
VAL A  70
GLY A  72
ALA A  75
 None
 1.02A 5jw1B-2wsxA:
undetectable		 5jw1B-2wsxA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xgt ASPARAGINYL-TRNA
SYNTHETASE,
CYTOPLASMIC

(Brugia malayi) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		5 ALA A 223
VAL A 235
GLY A 238
ALA A 241
LEU A 244
 None
 1.02A 5jw1B-2xgtA:
undetectable		 5jw1B-2xgtA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xzo REGULATOR OF
NONSENSE TRANSCRIPTS
1

(Homo sapiens) 		PF04851
(ResIII)
PF13086
(AAA_11)
PF13087
(AAA_12) 		5 LEU A 659
ALA A 299
VAL A 437
GLY A 653
ALA A 654
 None
 1.04A 5jw1B-2xzoA:
undetectable		 5jw1B-2xzoA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yr5 PRO-ENZYME OF
L-PHENYLALANINE
OXIDASE

(Pseudomonas sp.
P-501) 		no annotation 5 ALA A 236
VAL A 214
GLY A 211
ALA A 210
LEU A 206
 None
 0.98A 5jw1B-2yr5A:
undetectable		 5jw1B-2yr5A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ywd GLUTAMINE
AMIDOTRANSFERASE
SUBUNIT PDXT

(Thermus
thermophilus) 		PF01174
(SNO) 		5 LEU A 160
LEU A 144
GLY A  79
ALA A  84
LEU A 103
 None
 1.09A 5jw1B-2ywdA:
undetectable		 5jw1B-2ywdA:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a71 EXO-ARABINANASE

(Penicillium
chrysogenum) 		no annotation 5 LEU A 108
ALA A 340
GLY A 127
ALA A 126
LEU A 141
 None
 1.08A 5jw1B-3a71A:
undetectable		 5jw1B-3a71A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3at7 ALGINATE-BINDING
FLAGELLIN

(Sphingomonas
sp. A1) 		PF09375
(Peptidase_M75) 		5 LEU A  87
VAL A 158
GLY A 160
ALA A 162
LEU A 165
 None
 1.07A 5jw1B-3at7A:
undetectable		 5jw1B-3at7A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gdn R-OXYNITRILE LYASE
ISOENZYME 1

(Prunus dulcis) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 TYR A 457
ALA A 495
VAL A 113
GLY A 112
ALA A 111
 HBX  A 530 (-4.3A)
None
FAD  A 522 (-3.7A)
FAD  A 522 (-3.9A)
FAD  A 522 ( 3.0A)
 0.96A 5jw1B-3gdnA:
undetectable		 5jw1B-3gdnA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gxo MMCR

(Streptomyces
lavendulae) 		PF00891
(Methyltransf_2) 		5 LEU A 224
ALA A 186
GLY A 172
ALA A 171
LEU A 168
 None
 1.05A 5jw1B-3gxoA:
undetectable		 5jw1B-3gxoA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hdi PROCESSING PROTEASE

(Bacillus
halodurans) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		5 LEU A 400
LEU A 142
ALA A 410
GLY A 301
ALA A 300
 None
 1.05A 5jw1B-3hdiA:
undetectable		 5jw1B-3hdiA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjb GLUCOSE-6-PHOSPHATE
ISOMERASE

(Vibrio cholerae) 		PF00342
(PGI) 		5 ARG A 103
LEU A 486
ALA A 169
GLY A 297
ALA A 298
 None
 0.93A 5jw1B-3hjbA:
undetectable		 5jw1B-3hjbA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i83 2-DEHYDROPANTOATE
2-REDUCTASE

(Methylococcus
capsulatus) 		PF02558
(ApbA)
PF08546
(ApbA_C) 		5 GLN A 264
VAL A  80
GLY A  82
ALA A  83
LEU A  88
 None
 1.04A 5jw1B-3i83A:
undetectable		 5jw1B-3i83A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iwa FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE

(Desulfovibrio
vulgaris) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 HIS A  96
TYR A 113
GLY A 266
ALA A 265
LEU A 261
 None
 1.02A 5jw1B-3iwaA:
undetectable		 5jw1B-3iwaA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k1l FANCL

(Drosophila
melanogaster) 		no annotation 5 GLN B 211
LEU B 378
LEU B 343
GLY B 252
LEU B 371
 None
 1.08A 5jw1B-3k1lB:
undetectable		 5jw1B-3k1lB:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kc2 UNCHARACTERIZED
PROTEIN YKR070W

(Saccharomyces
cerevisiae) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		5 LEU A  50
ALA A 210
GLY A  33
ALA A  34
LEU A  38
 None
 1.08A 5jw1B-3kc2A:
undetectable		 5jw1B-3kc2A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l4d STEROL 14-ALPHA
DEMETHYLASE

(Leishmania
infantum) 		PF00067
(p450) 		5 LEU A 260
LEU A 187
VAL A 280
GLY A 282
LEU A 235
 None
 1.07A 5jw1B-3l4dA:
undetectable		 5jw1B-3l4dA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lvv GLUTAMATE--CYSTEINE
LIGASE

(Saccharomyces
cerevisiae) 		PF03074
(GCS) 		5 LEU A 186
ALA A 308
VAL A 316
GLY A 319
ALA A 320
 None
 0.91A 5jw1B-3lvvA:
undetectable		 5jw1B-3lvvA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n29 CARBOXYNORSPERMIDINE
DECARBOXYLASE

(Campylobacter
jejuni) 		PF00278
(Orn_DAP_Arg_deC) 		5 LEU A  56
ALA A  34
GLY A 235
ALA A  39
LEU A  40
 None
None
PLP  A1001 (-3.3A)
PLP  A1001 (-3.3A)
None
 1.02A 5jw1B-3n29A:
undetectable		 5jw1B-3n29A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r0z D-SERINE DEHYDRATASE

(Salmonella
enterica) 		PF00291
(PALP) 		5 LEU A  42
LEU A  37
ALA A  50
GLY A 283
LEU A 354
 None
 0.98A 5jw1B-3r0zA:
0.2		 5jw1B-3r0zA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r5g CYAB

(Pseudomonas
aeruginosa) 		PF00211
(Guanylate_cyc) 		5 LEU A 228
TYR A 336
GLY A 291
ALA A 292
LEU A 381
 None
 1.10A 5jw1B-3r5gA:
undetectable		 5jw1B-3r5gA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3skd PUTATIVE
UNCHARACTERIZED
PROTEIN TTHB187

(Thermus
thermophilus) 		no annotation 5 LEU A  59
LEU A 176
VAL A  35
ALA A  34
LEU A 230
 None
 0.93A 5jw1B-3skdA:
undetectable		 5jw1B-3skdA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3slk POLYKETIDE SYNTHASE
EXTENDER MODULE 2

(Saccharopolyspora
spinosa) 		PF08240
(ADH_N)
PF08659
(KR)
PF13602
(ADH_zinc_N_2) 		5 LEU A 663
ALA A 658
VAL A 622
GLY A 624
LEU A 629
 None
 0.92A 5jw1B-3slkA:
undetectable		 5jw1B-3slkA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sqg METHYL COENZYME M
REDUCTASE, ALPHA
SUBUNIT

(uncultured
archaeon) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N) 		5 ALA A 257
VAL A 153
GLY A 151
ALA A 147
LEU A 148
 M43  A1001 (-3.4A)
M43  A1001 (-3.5A)
None
None
None
 1.02A 5jw1B-3sqgA:
undetectable		 5jw1B-3sqgA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ss7 D-SERINE DEHYDRATASE

(Escherichia
coli) 		PF00291
(PALP) 		5 LEU X  44
LEU X  39
ALA X  52
GLY X 285
LEU X 356
 None
 0.93A 5jw1B-3ss7X:
0.0		 5jw1B-3ss7X:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tox SHORT CHAIN
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF13561
(adh_short_C2) 		5 LEU A 232
LEU A 187
ALA A  33
GLY A 238
ALA A 239
 None
 1.03A 5jw1B-3toxA:
undetectable		 5jw1B-3toxA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ugv ENOLASE

(alpha
proteobacterium
BAL199) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 LEU A 352
ALA A 117
GLY A 310
ALA A 311
LEU A 344
 None
 1.09A 5jw1B-3ugvA:
undetectable		 5jw1B-3ugvA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zz1 BETA-D-GLUCOSIDE
GLUCOHYDROLASE

(Trichoderma
reesei) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 LEU A 334
LEU A 341
VAL A 480
GLY A 504
ALA A 503
 None
 1.01A 5jw1B-3zz1A:
undetectable		 5jw1B-3zz1A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a5a NUCLEOSIDE-TRIPHOSPH
ATASE 1

(Toxoplasma
gondii) 		PF01150
(GDA1_CD39) 		5 ARG A 388
LEU A 357
ALA A 496
ALA A 333
LEU A 337
 None
None
ANP  A 700 (-3.5A)
None
None
 0.93A 5jw1B-4a5aA:
undetectable		 5jw1B-4a5aA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a6e HYDROXYINDOLE
O-METHYLTRANSFERASE

(Homo sapiens) 		PF00891
(Methyltransf_2)
PF16864
(Dimerisation2) 		5 HIS A 264
LEU A 250
GLY A 325
ALA A 324
LEU A 321
 None
 1.06A 5jw1B-4a6eA:
undetectable		 5jw1B-4a6eA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4em6 GLUCOSE-6-PHOSPHATE
ISOMERASE

(Brucella
melitensis) 		no annotation 5 ARG D   3
LEU D 317
VAL D  74
ALA D  72
LEU D   8
 None
 0.95A 5jw1B-4em6D:
undetectable		 5jw1B-4em6D:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g3j STEROL
14-ALPHA-DEMETHYLASE

(Trypanosoma
brucei) 		PF00067
(p450) 		5 LEU A 261
LEU A 188
VAL A 281
GLY A 283
LEU A 236
 None
 1.01A 5jw1B-4g3jA:
undetectable		 5jw1B-4g3jA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hqn SPOROZOITE SURFACE
PROTEIN 2

(Plasmodium
vivax) 		PF00090
(TSP_1)
PF00092
(VWA) 		5 LEU A 168
LEU A 133
GLY A 200
ALA A 199
LEU A 181
 None
 1.07A 5jw1B-4hqnA:
undetectable		 5jw1B-4hqnA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4idm DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF00171
(Aldedh) 		5 HIS A 262
ALA A 201
VAL A 183
GLY A 181
ALA A 259
 None
 1.08A 5jw1B-4idmA:
0.5		 5jw1B-4idmA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jb1 UDP-N-ACETYLENOLPYRU
VOYLGLUCOSAMINE
REDUCTASE

(Pseudomonas
aeruginosa) 		PF01565
(FAD_binding_4)
PF02873
(MurB_C) 		5 TYR A 165
LEU A 245
ALA A 131
GLY A 276
ALA A 275
 None
None
NAP  A 402 ( 3.3A)
None
None
 0.98A 5jw1B-4jb1A:
undetectable		 5jw1B-4jb1A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mdy PERIPLASMIC BINDING
PROTEIN

(Mycolicibacterium
smegmatis) 		PF01497
(Peripla_BP_2) 		5 LEU A  66
ALA A 166
GLY A  59
ALA A  58
LEU A 103
 None
 1.08A 5jw1B-4mdyA:
undetectable		 5jw1B-4mdyA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mfz DBV8 PROTEIN

(Nonomuraea
gerenzanensis) 		no annotation 5 TYR A 209
LEU A 204
ALA A 216
GLY A 234
LEU A 238
 None
MFK  A 401 (-4.6A)
None
MFK  A 401 ( 3.9A)
MFK  A 401 (-4.6A)
 0.86A 5jw1B-4mfzA:
undetectable		 5jw1B-4mfzA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nng 30S RIBOSOMAL
PROTEIN S1

(Mycobacterium
tuberculosis) 		PF00575
(S1) 		5 ALA A 365
VAL A 321
GLY A 308
ALA A 309
LEU A 304
 None
 0.99A 5jw1B-4nngA:
undetectable		 5jw1B-4nngA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o1m ENOYL-ACYL CARRIER
REDUCTASE

(Toxoplasma
gondii) 		PF13561
(adh_short_C2) 		5 LEU A 286
VAL A 266
GLY A 268
ALA A 270
LEU A 274
 None
 0.80A 5jw1B-4o1mA:
undetectable		 5jw1B-4o1mA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p9k TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Verminephrobacter
eiseniae) 		PF03480
(DctP) 		5 ARG A 278
GLN A 264
LEU A 139
GLY A 273
ALA A 274
 None
 0.94A 5jw1B-4p9kA:
undetectable		 5jw1B-4p9kA:
18.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ph9 PROSTAGLANDIN G/H
SYNTHASE 2

(Mus musculus) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		11 HIS A  90
ARG A 121
GLN A 193
LEU A 353
TYR A 356
LEU A 360
TRP A 388
ALA A 517
VAL A 524
GLY A 527
ALA A 528
 None
BOG  A 604 ( 3.7A)
None
IBP  A 601 ( 4.7A)
IBP  A 601 (-4.5A)
IBP  A 601 ( 4.7A)
None
None
IBP  A 601 ( 4.0A)
IBP  A 601 (-3.9A)
IBP  A 601 (-3.4A)
 0.76A 5jw1B-4ph9A:
62.7		 5jw1B-4ph9A:
99.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ph9 PROSTAGLANDIN G/H
SYNTHASE 2

(Mus musculus) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		11 HIS A  90
GLN A 193
LEU A 353
TYR A 356
LEU A 360
TRP A 388
ALA A 517
VAL A 524
GLY A 527
ALA A 528
LEU A 532
 None
None
IBP  A 601 ( 4.7A)
IBP  A 601 (-4.5A)
IBP  A 601 ( 4.7A)
None
None
IBP  A 601 ( 4.0A)
IBP  A 601 (-3.9A)
IBP  A 601 (-3.4A)
IBP  A 601 ( 4.9A)
 0.35A 5jw1B-4ph9A:
62.7		 5jw1B-4ph9A:
99.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r1d UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		no annotation 5 HIS A 279
LEU A 418
TYR A 423
ALA A 262
GLY A 286
 None
 1.00A 5jw1B-4r1dA:
undetectable		 5jw1B-4r1dA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rnc ESTERASE

(Rhodococcus sp.
ECU1013) 		PF12697
(Abhydrolase_6) 		5 LEU A 209
ALA A  95
VAL A  82
GLY A  80
ALA A  79
 None
 1.02A 5jw1B-4rncA:
undetectable		 5jw1B-4rncA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tqv ALGM1
ALGM2

(Sphingomonas
sp.) 		PF00528
(BPD_transp_1) 		5 LEU B 232
TYR B 213
VAL B 237
GLY A 150
ALA A 149
 None
 1.06A 5jw1B-4tqvB:
undetectable		 5jw1B-4tqvB:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wmj GLUCOSE-6-PHOSPHATE
ISOMERASE

(Colias
eurytheme) 		PF00342
(PGI) 		5 ARG A 108
LEU A 493
ALA A 174
GLY A 302
ALA A 303
 None
 0.98A 5jw1B-4wmjA:
undetectable		 5jw1B-4wmjA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xwu INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE

(Eremothecium
gossypii) 		PF00478
(IMPDH) 		5 ARG A 111
LEU A 263
ALA A 252
GLY A 270
ALA A 269
 None
 0.89A 5jw1B-4xwuA:
undetectable		 5jw1B-4xwuA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z19 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Yersinia pestis) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 LEU A  98
ALA A 122
VAL A 164
GLY A   7
ALA A  62
 None
 1.02A 5jw1B-4z19A:
undetectable		 5jw1B-4z19A:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ziu UNCHARACTERIZED
LIPOPROTEIN YFHM

(Escherichia
coli) 		PF07678
(A2M_comp) 		5 LEU A1401
ALA A1313
GLY A1340
ALA A1366
LEU A1367
 None
 1.02A 5jw1B-4ziuA:
undetectable		 5jw1B-4ziuA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8r METHYL-COENZYME M
REDUCTASE II SUBUNIT
ALPHA

(Methanothermobacter
marburgensis) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N) 		5 ALA A 246
VAL A 148
GLY A 146
ALA A 142
LEU A 143
 F43  A 603 (-3.3A)
F43  A 603 (-3.5A)
None
None
None
 1.10A 5jw1B-5a8rA:
undetectable		 5jw1B-5a8rA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5co4 PUTATIVE TRNA
(CYTIDINE(34)-2'-O)-
METHYLTRANSFERASE

(Thermus
thermophilus) 		no annotation 6 LEU B  98
LEU B 107
ALA B  90
GLY B 136
ALA B 134
LEU B 131
 None
None
None
None
MTA  B 401 (-3.5A)
MTA  B 401 ( 4.2A)
 1.30A 5jw1B-5co4B:
undetectable		 5jw1B-5co4B:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL

(Homo sapiens) 		PF00117
(GATase)
PF00988
(CPSase_sm_chain)
PF02142
(MGS)
PF02786
(CPSase_L_D2)
PF02787
(CPSase_L_D3) 		5 GLN A 375
LEU A 290
GLY A 305
ALA A 304
LEU A 282
 None
 1.05A 5jw1B-5dotA:
undetectable		 5jw1B-5dotA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dxi TREHALOSE-6-PHOSPHAT
E PHOSPHATASE

(Candida
albicans) 		PF02358
(Trehalose_PPase) 		5 LEU A  11
LEU A 226
GLY A 296
ALA A 295
LEU A  53
 None
 1.01A 5jw1B-5dxiA:
undetectable		 5jw1B-5dxiA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e24 SUPPRESSOR OF
HAIRLESS PROTEIN

(Drosophila
melanogaster) 		PF09270
(BTD)
PF09271
(LAG1-DNAbind) 		5 LEU E 125
LEU E 215
ALA E 262
ALA E 198
LEU E 189
 EDO  E 604 (-4.9A)
None
None
EDO  E 623 ( 3.9A)
None
 1.03A 5jw1B-5e24E:
undetectable		 5jw1B-5e24E:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fbz ENZYME SUBTILASE
SUBHAL FROM BACILLUS
HALMAPALUS

(Bacillus
halmapalus) 		PF00082
(Peptidase_S8)
PF04151
(PPC) 		5 ALA A 158
VAL A  72
GLY A  74
ALA A  73
LEU A  91
 None
None
5VV  A   1 ( 4.8A)
None
None
 0.94A 5jw1B-5fbzA:
undetectable		 5jw1B-5fbzA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ffn ENZYME SUBTILASE
SUBTY FROM BACILLUS
SP. TY145

(Bacillus sp.
(in: Bacteria)) 		PF00082
(Peptidase_S8) 		5 ALA A 167
VAL A  76
GLY A  78
ALA A  77
LEU A 100
 None
 1.02A 5jw1B-5ffnA:
undetectable		 5jw1B-5ffnA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h5z MHC CLASS I ANTIGEN

(Ctenopharyngodon
idella) 		no annotation 5 GLN A 152
TYR A  97
VAL A  65
GLY A  68
ALA A  69
 None
 1.07A 5jw1B-5h5zA:
undetectable		 5jw1B-5h5zA:
10.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ikr PROSTAGLANDIN G/H
SYNTHASE 2

(Homo sapiens) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		9 HIS A  90
ARG A 120
GLN A 192
TYR A 355
LEU A 359
TRP A 387
ALA A 516
GLY A 526
ALA A 527
 None
ID8  A 601 ( 4.4A)
None
ID8  A 601 (-3.8A)
None
COH  A 602 (-4.5A)
None
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
 0.82A 5jw1B-5ikrA:
61.1		 5jw1B-5ikrA:
87.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ikr PROSTAGLANDIN G/H
SYNTHASE 2

(Homo sapiens) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		11 HIS A  90
GLN A 192
LEU A 352
TYR A 355
LEU A 359
TRP A 387
ALA A 516
VAL A 523
GLY A 526
ALA A 527
LEU A 531
 None
None
ID8  A 601 (-4.1A)
ID8  A 601 (-3.8A)
None
COH  A 602 (-4.5A)
None
ID8  A 601 (-3.6A)
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
 0.49A 5jw1B-5ikrA:
61.1		 5jw1B-5ikrA:
87.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kei 2,3-DIHYDROXYBENZOAT
E-AMP LIGASE

(Mycolicibacterium
smegmatis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 LEU A 266
ALA A 106
GLY A 273
ALA A 274
LEU A 243
 None
 1.01A 5jw1B-5keiA:
undetectable		 5jw1B-5keiA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m32 PROTEASOME SUBUNIT
BETA TYPE-2

(Homo sapiens) 		PF00227
(Proteasome) 		5 LEU J   4
TYR J 117
GLY J 135
ALA J 136
LEU J 140
 None
 1.08A 5jw1B-5m32J:
undetectable		 5jw1B-5m32J:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mhk RS1

(Human
alphaherpesvirus
1) 		PF03584
(Herpes_ICP4_N) 		5 LEU A 432
LEU A 328
ALA A 446
GLY A 439
ALA A 438
 None
 1.07A 5jw1B-5mhkA:
undetectable		 5jw1B-5mhkA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n6m APOLIPOPROTEIN
N-ACYLTRANSFERASE

(Pseudomonas
aeruginosa) 		PF00795
(CN_hydrolase) 		5 LEU A  21
LEU A  26
ALA A  40
GLY A  64
ALA A  65
 None
 1.06A 5jw1B-5n6mA:
1.4		 5jw1B-5n6mA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tc3 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Eremothecium
gossypii) 		PF00478
(IMPDH)
PF00571
(CBS) 		5 ARG A 111
LEU A 263
ALA A 252
GLY A 270
ALA A 269
 None
 0.90A 5jw1B-5tc3A:
undetectable		 5jw1B-5tc3A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tkw TYPE II SECRETION
SYSTEM PROTEIN L

(Klebsiella
pneumoniae) 		PF05134
(T2SSL) 		5 LEU A  52
LEU A 135
ALA A  29
GLY A  39
LEU A  23
 None
 1.08A 5jw1B-5tkwA:
undetectable		 5jw1B-5tkwA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u4h UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Acinetobacter
baumannii) 		PF00275
(EPSP_synthase) 		5 LEU A 240
LEU A 379
VAL A  16
GLY A  14
LEU A  12
 None
 1.09A 5jw1B-5u4hA:
undetectable		 5jw1B-5u4hA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ug1 ACYLTRANSFERASE

(Streptococcus
pneumoniae) 		no annotation 5 LEU A 515
LEU A 434
ALA A 535
ALA A 593
LEU A 594
 None
 1.06A 5jw1B-5ug1A:
undetectable		 5jw1B-5ug1A:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uld TRANSPORTER, NADC
FAMILY

(Vibrio cholerae) 		PF00939
(Na_sulph_symp) 		5 LEU A 270
VAL A 295
GLY A 298
ALA A 299
LEU A 303
 None
 0.79A 5jw1B-5uldA:
undetectable		 5jw1B-5uldA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v2m MEVALONATE
DIPHOSPHATE
DECARBOXYLASE

(Enterococcus
faecalis) 		no annotation 5 LEU A 121
LEU A 133
VAL A  46
GLY A   4
ALA A 116
 None
 1.06A 5jw1B-5v2mA:
undetectable		 5jw1B-5v2mA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wu6 SPECKLE TARGETED
PIP5K1A-REGULATED
POLY(A) POLYMERASE

(Homo sapiens) 		PF00076
(RRM_1)
PF03828
(PAP_assoc) 		6 LEU A 422
LEU A 437
VAL A 559
GLY A 561
ALA A 560
LEU A 507
 None
 1.31A 5jw1B-5wu6A:
undetectable		 5jw1B-5wu6A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y09 PROTEASE DO-LIKE 9

(Arabidopsis
thaliana) 		no annotation 5 ALA A 565
VAL A 540
GLY A 538
ALA A 537
LEU A 586
 None
 1.09A 5jw1B-5y09A:
undetectable		 5jw1B-5y09A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yvs ALCOHOL
DEHYDROGENASE

(candidate
divison MSBL1
archaeon
SCGC-AAA259E19) 		no annotation 5 ALA A 160
VAL A  77
GLY A  80
ALA A  81
LEU A  85
 None
 0.68A 5jw1B-5yvsA:
undetectable		 5jw1B-5yvsA:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bac ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Neisseria
gonorrhoeae) 		no annotation 5 LEU A 147
LEU A 253
ALA A 345
GLY A 298
ALA A 299
 None
 0.87A 5jw1B-6bacA:
undetectable		 5jw1B-6bacA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6byq TYROSINE--TRNA
LIGASE

(Helicobacter
pylori) 		no annotation 5 LEU A  76
LEU A  63
TRP A 130
GLY A 186
ALA A 187
 None
 0.98A 5jw1B-6byqA:
undetectable		 5jw1B-6byqA:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1amu GRAMICIDIN
SYNTHETASE 1

(Brevibacillus
brevis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 VAL A 317
VAL A 284
ILE A 259
PHE A 229
 None
 0.87A 5jw1B-1amuA:
0.0		 5jw1B-1amuA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1avw TRYPSIN INHIBITOR

(Glycine max) 		PF00197
(Kunitz_legume) 		4 VAL B 670
SER B 521
ILE B 519
PHE B 673
 None
 1.03A 5jw1B-1avwB:
0.0		 5jw1B-1avwB:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c0w DIPHTHERIA TOXIN
REPRESSOR

(Corynebacterium
diphtheriae) 		PF01325
(Fe_dep_repress)
PF02742
(Fe_dep_repr_C) 		4 VAL A  56
SER A  61
ARG A  29
ILE A  15
 None
 1.00A 5jw1B-1c0wA:
0.0		 5jw1B-1c0wA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cfr RESTRICTION
ENDONUCLEASE

(Citrobacter
freundii) 		PF07832
(Bse634I) 		4 VAL A  22
SER A  26
ILE A  30
PHE A 156
 None
 0.93A 5jw1B-1cfrA:
0.0		 5jw1B-1cfrA:
18.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ebv PROSTAGLANDIN H2
SYNTHASE

(Ovis aries) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		4 VAL A 116
VAL A 349
SER A 353
ILE A 517
 None
SCL  A 700 ( 4.6A)
None
None
 0.25A 5jw1B-1ebvA:
57.4		 5jw1B-1ebvA:
64.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ebv PROSTAGLANDIN H2
SYNTHASE

(Ovis aries) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		4 VAL A 349
SER A 353
ILE A 517
PHE A 518
 SCL  A 700 ( 4.6A)
None
None
None
 0.78A 5jw1B-1ebvA:
57.4		 5jw1B-1ebvA:
64.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1es6 MATRIX PROTEIN VP40

(Ebola virus sp.) 		PF07447
(VP40) 		4 VAL A 162
SER A 316
ARG A 214
ILE A 216
 None
 0.95A 5jw1B-1es6A:
0.0		 5jw1B-1es6A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f5t DIPHTHERIA TOXIN
REPRESSOR

(Corynebacterium
diphtheriae) 		PF01325
(Fe_dep_repress)
PF02742
(Fe_dep_repr_C) 		4 VAL A1056
SER A1061
ARG A1029
ILE A1015
 None
 1.06A 5jw1B-1f5tA:
undetectable		 5jw1B-1f5tA:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f82 BOTULINUM NEUROTOXIN
TYPE B

(Clostridium
botulinum) 		PF01742
(Peptidase_M27) 		4 VAL A 205
VAL A 201
SER A 221
ILE A 382
 None
 1.07A 5jw1B-1f82A:
0.0		 5jw1B-1f82A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hyb NICOTINAMIDE
MONONUCLEOTIDE
ADENYLYLTRANSFERASE

(Methanothermobacter
thermautotrophicus) 		PF01467
(CTP_transf_like) 		4 VAL A 153
VAL A 135
ARG A 165
ILE A  46
 None
 1.06A 5jw1B-1hybA:
undetectable		 5jw1B-1hybA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mhy METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylosinus
trichosporium) 		PF02332
(Phenol_Hydrox) 		4 VAL B 380
VAL B 254
ILE B 298
PHE B 302
 None
 1.00A 5jw1B-1mhyB:
undetectable		 5jw1B-1mhyB:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mkp PYST1

(Homo sapiens) 		PF00782
(DSPc) 		4 VAL A 323
VAL A 291
SER A 300
ILE A 260
 None
 0.99A 5jw1B-1mkpA:
undetectable		 5jw1B-1mkpA:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ozh ACETOLACTATE
SYNTHASE, CATABOLIC

(Klebsiella
pneumoniae) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 VAL A 148
VAL A  26
ILE A  52
PHE A  30
 None
 0.75A 5jw1B-1ozhA:
0.0		 5jw1B-1ozhA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qon ACETYLCHOLINESTERASE

(Drosophila
melanogaster) 		PF00135
(COesterase) 		4 VAL A 304
SER A 306
ARG A  45
PHE A  44
 None
 1.02A 5jw1B-1qonA:
undetectable		 5jw1B-1qonA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qs2 ADP-RIBOSYLTRANSFERA
SE

(Bacillus cereus) 		PF03496
(ADPrib_exo_Tox) 		4 VAL A 442
ARG A 180
ILE A 182
PHE A 177
 None
 1.01A 5jw1B-1qs2A:
undetectable		 5jw1B-1qs2A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rvk ISOMERASE/LACTONIZIN
G ENZYME

(Agrobacterium
fabrum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 VAL A   8
ARG A  12
ILE A 376
PHE A  11
 None
 0.93A 5jw1B-1rvkA:
undetectable		 5jw1B-1rvkA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ukc ESTA

(Aspergillus
niger) 		PF00135
(COesterase) 		4 VAL A 328
VAL A 236
ILE A 447
PHE A 477
 None
 0.96A 5jw1B-1ukcA:
undetectable		 5jw1B-1ukcA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uqw PUTATIVE BINDING
PROTEIN YLIB

(Escherichia
coli) 		PF00496
(SBP_bac_5) 		4 VAL A 421
VAL A 290
ARG A 263
ILE A 455
 None
 1.05A 5jw1B-1uqwA:
undetectable		 5jw1B-1uqwA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wod MODA

(Escherichia
coli) 		PF13531
(SBP_bac_11) 		4 VAL A 175
VAL A  88
ILE A 100
PHE A 186
 None
 1.00A 5jw1B-1wodA:
undetectable		 5jw1B-1wodA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z1w TRICORN PROTEASE
INTERACTING FACTOR
F3

(Thermoplasma
acidophilum) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		4 VAL A 486
VAL A 447
ARG A 359
ILE A 361
 None
 0.88A 5jw1B-1z1wA:
1.0		 5jw1B-1z1wA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ztv HYPOTHETICAL PROTEIN

(Enterococcus
faecalis) 		PF01904
(DUF72) 		4 VAL A  62
VAL A 165
SER A 163
ARG A 127
 None
 0.90A 5jw1B-1ztvA:
undetectable		 5jw1B-1ztvA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ag1 BENZALDEHYDE LYASE

(Pseudomonas
fluorescens) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 VAL A 142
VAL A  19
ILE A  45
PHE A  23
 None
 1.00A 5jw1B-2ag1A:
undetectable		 5jw1B-2ag1A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eve HYPOTHETICAL PROTEIN
PSPTO5229

(Pseudomonas
syringae group
genomosp. 3) 		PF01878
(EVE) 		4 VAL A  66
VAL A 102
ILE A  59
PHE A  48
 None
 1.03A 5jw1B-2eveA:
undetectable		 5jw1B-2eveA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g3n ALPHA-GLUCOSIDASE

(Sulfolobus
solfataricus) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		4 VAL A 491
VAL A 206
ILE A 247
PHE A 210
 None
 1.09A 5jw1B-2g3nA:
undetectable		 5jw1B-2g3nA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gm5 TRANSPOSON
GAMMA-DELTA
RESOLVASE

(Escherichia
coli) 		PF00239
(Resolvase) 		4 VAL A 107
ARG A  91
ILE A  90
PHE A  92
 None
 0.95A 5jw1B-2gm5A:
undetectable		 5jw1B-2gm5A:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gsr CLASS PI GST
GLUTATHIONE
S-TRANSFERASE

(Sus scrofa) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		4 VAL A 178
VAL A 162
ARG A  98
ILE A 105
 None
 1.06A 5jw1B-2gsrA:
undetectable		 5jw1B-2gsrA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2haw MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE

(Bacillus
subtilis) 		PF01368
(DHH)
PF02833
(DHHA2) 		4 VAL A 302
VAL A 253
ILE A 238
PHE A 250
 None
 1.04A 5jw1B-2hawA:
undetectable		 5jw1B-2hawA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iph THIOL PROTEASE P3C

(Norwalk virus) 		PF05416
(Peptidase_C37) 		4 VAL A1153
ARG A1059
ILE A1047
PHE A1060
 None
 0.80A 5jw1B-2iphA:
undetectable		 5jw1B-2iphA:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o56 PUTATIVE MANDELATE
RACEMASE

(Salmonella
enterica) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 VAL A 263
VAL A 248
ILE A 273
PHE A 282
 None
 0.93A 5jw1B-2o56A:
0.0		 5jw1B-2o56A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o9a ACETATE OPERON
REPRESSOR

(Escherichia
coli) 		PF01614
(IclR) 		4 VAL A 172
VAL A  26
ILE A 153
PHE A 161
 None
 1.07A 5jw1B-2o9aA:
undetectable		 5jw1B-2o9aA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pjp SELENOCYSTEINE-SPECI
FIC ELONGATION
FACTOR

(Escherichia
coli) 		PF09107
(SelB-wing_3) 		4 VAL A 578
ARG A 546
ILE A 536
PHE A 502
 None
 0.97A 5jw1B-2pjpA:
undetectable		 5jw1B-2pjpA:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4

(Saccharopolyspora
erythraea) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 VAL A 749
VAL A 722
SER A 724
PHE A 733
 None
 0.95A 5jw1B-2qo3A:
undetectable		 5jw1B-2qo3A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v26 MYOSIN VI

(Sus scrofa) 		PF00063
(Myosin_head) 		4 VAL A 164
SER A 664
ILE A 488
PHE A 484
 None
 0.90A 5jw1B-2v26A:
undetectable		 5jw1B-2v26A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x30 PHOSPHORIBOSYL
ISOMERASE A

(Streptomyces
coelicolor) 		PF00977
(His_biosynth) 		4 VAL A  52
VAL A 164
SER A 196
ILE A 208
 None
None
SO4  A1242 ( 4.8A)
None
 0.90A 5jw1B-2x30A:
undetectable		 5jw1B-2x30A:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xro HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGV

(Pseudomonas
putida) 		PF01614
(IclR)
PF09339
(HTH_IclR) 		4 VAL A 140
VAL A 223
SER A 109
ILE A 124
 None
 1.09A 5jw1B-2xroA:
undetectable		 5jw1B-2xroA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y89 PHOSPHORIBOSYL
ISOMERASE A

(Mycobacterium
tuberculosis) 		PF00977
(His_biosynth) 		4 VAL A  52
VAL A 168
SER A 200
ILE A 212
 None
 0.83A 5jw1B-2y89A:
undetectable		 5jw1B-2y89A:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yyt OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE

(Geobacillus
kaustophilus) 		PF00215
(OMPdecase) 		4 VAL A  81
VAL A  86
ILE A   8
PHE A  32
 None
 1.06A 5jw1B-2yytA:
undetectable		 5jw1B-2yytA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ddu PROLYL ENDOPEPTIDASE

(Homo sapiens) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		4 VAL A 455
VAL A 379
SER A 400
ILE A 382
 ACT  A 802 ( 4.3A)
None
None
None
 1.09A 5jw1B-3dduA:
undetectable		 5jw1B-3dduA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dh4 SODIUM/GLUCOSE
COTRANSPORTER

(Vibrio
parahaemolyticus) 		PF00474
(SSF) 		4 VAL A 460
VAL A 132
ILE A 139
PHE A 140
 None
 0.87A 5jw1B-3dh4A:
undetectable		 5jw1B-3dh4A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dm0 MALTOSE-BINDING
PERIPLASMIC PROTEIN
FUSED WITH RACK1

(Arabidopsis
thaliana;
Escherichia
coli) 		PF00400
(WD40)
PF01547
(SBP_bac_1) 		4 SER A1122
ARG A1157
ILE A1167
PHE A1158
 None
 0.90A 5jw1B-3dm0A:
undetectable		 5jw1B-3dm0A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gwq D-SERINE DEAMINASE

(Paraburkholderia
xenovorans) 		PF01168
(Ala_racemase_N)
PF14031
(D-ser_dehydrat) 		4 VAL A 410
ARG A  87
ILE A  97
PHE A  86
 None
GOL  A 426 (-3.6A)
None
None
 1.08A 5jw1B-3gwqA:
undetectable		 5jw1B-3gwqA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hcz POSSIBLE
THIOL-DISULFIDE
ISOMERASE

(Cytophaga
hutchinsonii) 		PF00578
(AhpC-TSA) 		4 VAL A 355
VAL A 420
ILE A 398
PHE A 429
 None
 1.06A 5jw1B-3hczA:
undetectable		 5jw1B-3hczA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hfq UNCHARACTERIZED
PROTEIN LP_2219

(Lactobacillus
plantarum) 		PF10282
(Lactonase) 		4 VAL A 302
ARG A 338
ILE A   5
PHE A 339
 None
 0.93A 5jw1B-3hfqA:
undetectable		 5jw1B-3hfqA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhg TRANSCRIPTIONAL
REGULATOR, LYSR
FAMILY

(Neisseria
meningitidis) 		PF00126
(HTH_1)
PF03466
(LysR_substrate) 		4 VAL A 127
SER A 125
ARG A 281
PHE A 285
 None
 1.08A 5jw1B-3hhgA:
undetectable		 5jw1B-3hhgA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i27 HEMAGGLUTININ-ESTERA
SE

(Bovine
torovirus) 		PF02710
(Hema_HEFG)
PF03996
(Hema_esterase) 		4 VAL A  81
SER A  37
ILE A  52
PHE A  60
 None
 1.05A 5jw1B-3i27A:
undetectable		 5jw1B-3i27A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihy PHOSPHATIDYLINOSITOL
3-KINASE CATALYTIC
SUBUNIT TYPE 3

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka) 		4 VAL A 381
SER A 481
ARG A 523
PHE A 524
 None
 0.98A 5jw1B-3ihyA:
undetectable		 5jw1B-3ihyA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k2b GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
A, CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 VAL A  57
SER A  41
ILE A  30
PHE A   8
 None
 1.06A 5jw1B-3k2bA:
undetectable		 5jw1B-3k2bA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k4w UNCHARACTERIZED
PROTEIN BB4693

(Bordetella
bronchiseptica) 		PF04909
(Amidohydro_2) 		5 VAL A 133
VAL A 184
SER A 186
ARG A   7
PHE A   6
 None
 1.24A 5jw1B-3k4wA:
undetectable		 5jw1B-3k4wA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k70 EXODEOXYRIBONUCLEASE
V ALPHA CHAIN

(Escherichia
coli) 		PF13538
(UvrD_C_2)
PF13604
(AAA_30) 		4 VAL D 292
SER D 167
ILE D 313
PHE D 123
 None
 1.07A 5jw1B-3k70D:
undetectable		 5jw1B-3k70D:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ke6 PROTEIN
RV1364C/MT1410

(Mycobacterium
tuberculosis) 		PF07228
(SpoIIE)
PF13581
(HATPase_c_2) 		4 VAL A 450
VAL A 417
SER A 443
ILE A 438
 None
 0.99A 5jw1B-3ke6A:
undetectable		 5jw1B-3ke6A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l09 PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Jannaschia sp.
CCS1) 		PF07848
(PaaX) 		4 VAL A 172
SER A 221
ARG A 219
ILE A 217
 None
 0.98A 5jw1B-3l09A:
undetectable		 5jw1B-3l09A:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lv4 GLYCOSIDE HYDROLASE
YXIA

(Bacillus
licheniformis) 		PF04616
(Glyco_hydro_43)
PF16369
(GH43_C) 		4 VAL A 362
VAL A 260
ILE A 227
PHE A 247
 None
 0.91A 5jw1B-3lv4A:
undetectable		 5jw1B-3lv4A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pfn NAD KINASE

(Homo sapiens) 		PF01513
(NAD_kinase) 		4 VAL A 157
VAL A 109
ILE A 171
PHE A 164
 None
 1.06A 5jw1B-3pfnA:
undetectable		 5jw1B-3pfnA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qnk PUTATIVE LIPOPROTEIN

(Bacteroides
fragilis) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 VAL A 108
VAL A 153
ARG A 531
ILE A 529
 None
 1.04A 5jw1B-3qnkA:
undetectable		 5jw1B-3qnkA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r4v PUTATIVE
UNCHARACTERIZED
PROTEIN

(Pseudomonas
phage 201phi2-1) 		PF00091
(Tubulin) 		4 VAL A 208
VAL A 117
SER A 115
ILE A 172
 None
 1.08A 5jw1B-3r4vA:
undetectable		 5jw1B-3r4vA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rfy PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
CYP38, CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00160
(Pro_isomerase) 		4 VAL A 295
VAL A  93
ARG A 290
ILE A 288
 None
 1.03A 5jw1B-3rfyA:
undetectable		 5jw1B-3rfyA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s8d COENZYME A
TRANSFERASE

(Yersinia pestis) 		PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C) 		4 VAL A 302
ARG A 353
ILE A 311
PHE A 351
 None
 1.05A 5jw1B-3s8dA:
undetectable		 5jw1B-3s8dA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t8l ADENINE DEAMINASE 2

(Agrobacterium
fabrum) 		PF01979
(Amidohydro_1)
PF13382
(Adenine_deam_C) 		4 VAL A 109
VAL A 291
SER A  98
PHE A 538
 None
 0.94A 5jw1B-3t8lA:
0.0		 5jw1B-3t8lA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqh QUINONE
OXIDOREDUCTASE

(Coxiella
burnetii) 		PF08240
(ADH_N)
PF13602
(ADH_zinc_N_2) 		4 VAL A 314
VAL A  37
SER A  73
ILE A 116
 None
 1.01A 5jw1B-3tqhA:
undetectable		 5jw1B-3tqhA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tzw POLYKETIDE SYNTHASE
PKS13

(Mycobacterium
tuberculosis) 		PF00698
(Acyl_transf_1) 		4 VAL A 940
SER A 807
ILE A 781
PHE A 777
 None
 1.09A 5jw1B-3tzwA:
undetectable		 5jw1B-3tzwA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x1l CMR4

(Archaeoglobus
fulgidus) 		PF03787
(RAMPs) 		4 VAL C  19
VAL C  53
ILE C 295
PHE C  11
 None
G  I   8 ( 4.3A)
None
None
 0.98A 5jw1B-3x1lC:
undetectable		 5jw1B-3x1lC:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4anj UNCONVENTIONAL
MYOSIN-VI, GREEN
FLUORESCENT PROTEIN

(Aequorea
victoria;
Sus scrofa) 		PF00063
(Myosin_head)
PF01353
(GFP) 		4 VAL A 164
SER A 664
ILE A 488
PHE A 484
 None
 0.89A 5jw1B-4anjA:
undetectable		 5jw1B-4anjA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cyf PANTETHEINASE

(Homo sapiens) 		PF00795
(CN_hydrolase) 		4 VAL A 248
SER A 252
ILE A 214
PHE A 234
 None
None
CSO  A 211 ( 3.9A)
CSO  A 211 ( 4.0A)
 0.99A 5jw1B-4cyfA:
undetectable		 5jw1B-4cyfA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d6v G PROTEIN BETA
SUBUNIT GIB2

(Cryptococcus
neoformans) 		PF00400
(WD40) 		4 SER A 122
ARG A 155
ILE A 165
PHE A 156
 None
 0.90A 5jw1B-4d6vA:
undetectable		 5jw1B-4d6vA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h14 SPIKE GLYCOPROTEIN

(Betacoronavirus
1) 		PF16451
(Spike_NTD) 		4 VAL A 191
VAL A 139
SER A 137
PHE A 219
 None
 1.08A 5jw1B-4h14A:
undetectable		 5jw1B-4h14A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ifa EXTRACELLULAR
PROTEIN CONTAINING A
SCP DOMAIN

(Bacillus
anthracis) 		PF00188
(CAP)
PF14504
(CAP_assoc_N) 		4 VAL A 130
VAL A 185
ARG A 239
ILE A 235
 None
None
TRS  A 406 (-3.1A)
None
 0.80A 5jw1B-4ifaA:
undetectable		 5jw1B-4ifaA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iug BETA-GALACTOSIDASE A

(Aspergillus
oryzae) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		4 VAL A 479
VAL A 474
SER A 487
ILE A 456
 None
 1.07A 5jw1B-4iugA:
undetectable		 5jw1B-4iugA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lct COP9 SIGNALOSOME
COMPLEX SUBUNIT 1

(Arabidopsis
thaliana) 		PF01399
(PCI)
PF10602
(RPN7) 		4 VAL A 252
VAL A 195
ILE A 163
PHE A 159
 None
 1.07A 5jw1B-4lctA:
undetectable		 5jw1B-4lctA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lhb MOLYBDOPTERIN
ADENYLYLTRANSFERASE

(Pyrococcus
furiosus) 		PF00994
(MoCF_biosynth) 		4 VAL A  61
VAL A 139
SER A 141
ILE A 156
 None
 1.05A 5jw1B-4lhbA:
undetectable		 5jw1B-4lhbA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lp2 HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CYSB

(Salmonella
enterica) 		PF03466
(LysR_substrate) 		4 VAL B 171
SER B 169
ILE B 264
PHE B 265
 None
 1.03A 5jw1B-4lp2B:
undetectable		 5jw1B-4lp2B:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m7e PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF12799
(LRR_4)
PF13516
(LRR_6)
PF13855
(LRR_8) 		4 VAL A 282
SER A 258
ILE A 276
PHE A 261
 None
 0.98A 5jw1B-4m7eA:
undetectable		 5jw1B-4m7eA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o1s V-TYPE ATP SYNTHASE
ALPHA CHAIN

(Thermoplasma
volcanium) 		PF14890
(Intein_splicing) 		4 VAL A  58
VAL A 151
SER A  65
ILE A  52
 None
 1.08A 5jw1B-4o1sA:
undetectable		 5jw1B-4o1sA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oya ADENYLATE CYCLASE
TYPE 10

(Homo sapiens) 		PF00211
(Guanylate_cyc) 		4 VAL A 167
ARG A  33
ILE A 314
PHE A 157
 1VE  A 501 (-3.7A)
None
None
None
 1.05A 5jw1B-4oyaA:
undetectable		 5jw1B-4oyaA:
20.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ph9 PROSTAGLANDIN G/H
SYNTHASE 2

(Mus musculus) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		6 VAL A 117
VAL A 350
SER A 354
ARG A 514
ILE A 518
PHE A 519
 BOG  A 604 (-3.9A)
IBP  A 601 (-4.3A)
None
None
None
None
 0.30A 5jw1B-4ph9A:
62.7		 5jw1B-4ph9A:
99.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4psm SSDNA BINDING
PROTEIN

(Pyrococcus
furiosus) 		PF10015
(DUF2258) 		4 VAL A   9
VAL A  21
ILE A  74
PHE A  67
 None
 1.04A 5jw1B-4psmA:
undetectable		 5jw1B-4psmA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4puf E3 UBIQUITIN-PROTEIN
LIGASE SLRP

(Salmonella
enterica) 		PF12468
(TTSSLRR)
PF14496
(NEL) 		4 VAL A 550
VAL A 599
ILE A 639
PHE A 614
 None
 1.07A 5jw1B-4pufA:
undetectable		 5jw1B-4pufA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rjk ACETOLACTATE
SYNTHASE

(Bacillus
subtilis) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 VAL A 152
VAL A  30
ILE A  56
PHE A  34
 None
 0.87A 5jw1B-4rjkA:
undetectable		 5jw1B-4rjkA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tw0 SCAVENGER RECEPTOR
CLASS B MEMBER 2

(Homo sapiens) 		PF01130
(CD36) 		4 VAL A 173
VAL A 408
ILE A  75
PHE A 168
 None
 1.04A 5jw1B-4tw0A:
undetectable		 5jw1B-4tw0A:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u28 PHOSPHORIBOSYL
ISOMERASE A

(Streptomyces
sviceus) 		PF00977
(His_biosynth) 		4 VAL A  56
VAL A 168
SER A 200
ILE A 212
 None
None
PO4  A 301 ( 4.4A)
None
 0.85A 5jw1B-4u28A:
undetectable		 5jw1B-4u28A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wwv AMINOPEPTIDASE FROM
FAMILY M42

(Desulfurococcus
amylolyticus) 		PF05343
(Peptidase_M42) 		4 VAL A 106
SER A  18
ARG A 186
ILE A  13
 None
 1.08A 5jw1B-4wwvA:
undetectable		 5jw1B-4wwvA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xdt FAD:PROTEIN FMN
TRANSFERASE

(Treponema
pallidum) 		PF02424
(ApbE) 		4 VAL A 229
SER A 231
ILE A 325
PHE A 276
 None
None
EDO  A 410 ( 4.4A)
None
 0.95A 5jw1B-4xdtA:
undetectable		 5jw1B-4xdtA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y18 BREAST CANCER TYPE 1
SUSCEPTIBILITY
PROTEIN

(Homo sapiens) 		PF00533
(BRCT) 		4 VAL A1833
SER A1841
ARG A1699
ILE A1707
 None
 0.97A 5jw1B-4y18A:
undetectable		 5jw1B-4y18A:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zwj CHIMERA PROTEIN OF
HUMAN RHODOPSIN,
MOUSE S-ARRESTIN,
AND T4 ENDOLYSIN

(Escherichia
virus T4;
Homo sapiens;
Mus musculus) 		PF00001
(7tm_1)
PF00339
(Arrestin_N)
PF00959
(Phage_lysozyme)
PF02752
(Arrestin_C)
PF10413
(Rhodopsin_N) 		4 VAL A 157
SER A 127
ARG A 135
ILE A 133
 None
 0.98A 5jw1B-4zwjA:
undetectable		 5jw1B-4zwjA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b6k UNCHARACTERIZED
PROTEIN CGKR1

([Candida]
glabrata) 		PF01370
(Epimerase) 		4 VAL A 207
SER A 134
ARG A 272
ILE A 204
 None
 1.08A 5jw1B-5b6kA:
undetectable		 5jw1B-5b6kA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5far 7,8-DIHYDRONEOPTERIN
ALDOLASE

(Bacillus cereus) 		PF02152
(FolB) 		4 VAL A  72
SER A  74
ARG A 117
ILE A  79
 None
 0.93A 5jw1B-5farA:
undetectable		 5jw1B-5farA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h08 RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE ZETA

(Homo sapiens) 		PF00102
(Y_phosphatase) 		4 VAL A1931
VAL A1945
SER A1948
ILE A1953
 None
 1.08A 5jw1B-5h08A:
undetectable		 5jw1B-5h08A:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h9d HEPTAPRENYL
DIPHOSPHATE SYNTHASE
(HEPPP SYNTHASE)
SUBUNIT 1 FAMILY
PROTEIN

(Staphylococcus
aureus) 		PF07307
(HEPPP_synt_1) 		4 VAL C 102
SER C  98
ILE C  51
PHE C 132
 None
 0.94A 5jw1B-5h9dC:
undetectable		 5jw1B-5h9dC:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ihr PROBABLE
BETA-GALACTOSIDASE A

(Aspergillus
niger) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		4 VAL A 479
VAL A 474
SER A 487
ILE A 456
 None
 1.05A 5jw1B-5ihrA:
undetectable		 5jw1B-5ihrA:
18.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ikr PROSTAGLANDIN G/H
SYNTHASE 2

(Homo sapiens) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		6 VAL A 116
VAL A 349
SER A 353
ARG A 513
ILE A 517
PHE A 518
 None
ID8  A 601 (-3.9A)
ID8  A 601 ( 4.7A)
None
None
None
 0.35A 5jw1B-5ikrA:
61.1		 5jw1B-5ikrA:
87.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lon KLLA0E01827P

(Kluyveromyces
lactis) 		PF06058
(DCP1) 		4 VAL B  17
VAL B  53
ILE B 171
PHE B  30
 None
 1.02A 5jw1B-5lonB:
undetectable		 5jw1B-5lonB:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oyd CELLULASE, PUTATIVE,
CEL5D

(Cellvibrio
japonicus) 		no annotation 4 VAL A 192
VAL A 164
ILE A 444
PHE A 445
 None
 1.05A 5jw1B-5oydA:
undetectable		 5jw1B-5oydA:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5szr PROTEIN PCDHGB2

(Mus musculus) 		PF00028
(Cadherin) 		4 VAL A 258
VAL A 289
SER A 302
PHE A 217
 None
 1.05A 5jw1B-5szrA:
undetectable		 5jw1B-5szrA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xh9 EXTRACELLULAR
INVERTASE

(Aspergillus
kawachii) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		4 VAL A 588
SER A 590
ARG A 533
ILE A 538
 None
 1.04A 5jw1B-5xh9A:
undetectable		 5jw1B-5xh9A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xni MCYF

(Microcystis
aeruginosa) 		no annotation 4 VAL A  18
VAL A  10
ILE A 230
PHE A 226
 None
 0.95A 5jw1B-5xniA:
undetectable		 5jw1B-5xniA:
8.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zvs VP2

(Aquareovirus C) 		no annotation 4 VAL 2 398
SER 2 684
ARG 2 666
PHE 2 681
 None
 0.97A 5jw1B-5zvs2:
undetectable		 5jw1B-5zvs2:
9.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6etz BETA-GALACTOSIDASE

(Arthrobacter
sp. 32cB) 		no annotation 4 VAL A 387
VAL A 477
SER A 479
ILE A 491
 None
 1.03A 5jw1B-6etzA:
undetectable		 5jw1B-6etzA:
8.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fk6 RHODOPSIN

(Bos taurus) 		no annotation 4 VAL A 157
SER A 127
ARG A 135
ILE A 133
 None
 1.07A 5jw1B-6fk6A:
undetectable		 5jw1B-6fk6A:
8.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g8r NUCLEAR BODY PROTEIN
SP140

(Homo sapiens) 		no annotation 4 VAL B 857
ARG B 824
ILE B 826
PHE B 827
 None
 1.01A 5jw1B-6g8rB:
undetectable		 5jw1B-6g8rB:
8.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gct NEUTRAL AMINO ACID
TRANSPORTER B(0)

(Homo sapiens) 		no annotation 4 VAL A 270
SER A 111
ILE A 113
PHE A 259
 None
 1.04A 5jw1B-6gctA:
undetectable		 5jw1B-6gctA:
9.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gng -

(-) 		no annotation 4 VAL A 529
VAL A 166
ARG A  99
ILE A  59
 None
 1.08A 5jw1B-6gngA:
0.0		 5jw1B-6gngA:
undetectable