SIMILAR PATTERNS OF AMINO ACIDS FOR 5JVZ_A_FLPA601_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b9h PROTEIN
(3-AMINO-5-HYDROXYBE
NZOIC ACID SYNTHASE)

(Amycolatopsis
mediterranei) 		PF01041
(DegT_DnrJ_EryC1) 		5 LEU A 362
VAL A 276
GLY A 271
SER A 267
LEU A 266
 None
 1.05A 5jvzA-1b9hA:
0.0		 5jvzA-1b9hA:
21.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ebv PROSTAGLANDIN H2
SYNTHASE

(Ovis aries) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		10 ARG A 120
VAL A 349
LEU A 352
TYR A 355
LEU A 359
TYR A 385
TRP A 387
GLY A 526
ALA A 527
LEU A 531
 SCL  A 700 (-3.9A)
SCL  A 700 ( 4.6A)
SCL  A 700 ( 4.8A)
SCL  A 700 (-4.3A)
None
None
None
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
OAS  A 530 (-4.1A)
 0.56A 5jvzA-1ebvA:
58.5		 5jvzA-1ebvA:
64.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g01 ENDOGLUCANASE

(Bacillus sp.
KSM-635) 		PF00150
(Cellulase)
PF03424
(CBM_17_28) 		5 LEU A 544
LEU A 282
GLY A 529
ALA A 530
SER A 520
 None
 1.09A 5jvzA-1g01A:
0.0		 5jvzA-1g01A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hbr PROTEIN (HEMOGLOBIN
D)

(Gallus gallus) 		PF00042
(Globin) 		5 VAL A 132
LEU A  76
LEU A 136
GLY A  67
ALA A  65
 None
None
None
None
HEM  A 142 ( 3.9A)
 1.10A 5jvzA-1hbrA:
0.8		 5jvzA-1hbrA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i8d RIBOFLAVIN SYNTHASE

(Escherichia
coli) 		PF00677
(Lum_binding) 		5 VAL A  59
LEU A  28
GLY A  39
ALA A  40
LEU A  36
 None
 1.05A 5jvzA-1i8dA:
undetectable		 5jvzA-1i8dA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1itk CATALASE-PEROXIDASE

(Haloarcula
marismortui) 		PF00141
(peroxidase) 		5 VAL A 507
LEU A 511
LEU A 504
GLY A 538
ALA A 467
 None
 1.05A 5jvzA-1itkA:
1.1		 5jvzA-1itkA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jy1 TYROSYL-DNA
PHOSPHODIESTERASE

(Homo sapiens) 		PF06087
(Tyr-DNA_phospho) 		5 VAL A 227
TYR A 537
ALA A 332
SER A 334
LEU A 335
 None
 0.93A 5jvzA-1jy1A:
0.0		 5jvzA-1jy1A:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nvt SHIKIMATE
5'-DEHYDROGENASE

(Methanocaldococcus
jannaschii) 		PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N) 		5 VAL A 226
TYR A 134
LEU A 238
VAL A 194
LEU A 220
 None
 0.92A 5jvzA-1nvtA:
undetectable		 5jvzA-1nvtA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1otk PHENYLACETIC ACID
DEGRADATION PROTEIN
PAAC

(Escherichia
coli) 		PF05138
(PaaA_PaaC) 		5 LEU A   5
LEU A  12
GLY A 184
SER A 115
LEU A 112
 None
 1.04A 5jvzA-1otkA:
undetectable		 5jvzA-1otkA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q77 HYPOTHETICAL PROTEIN
AQ_178

(Aquifex
aeolicus) 		PF00582
(Usp) 		5 VAL A 102
LEU A   4
VAL A 123
GLY A 126
LEU A 129
 None
 0.93A 5jvzA-1q77A:
undetectable		 5jvzA-1q77A:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sez PROTOPORPHYRINOGEN
OXIDASE,
MITOCHONDRIAL

(Nicotiana
tabacum) 		PF01593
(Amino_oxidase) 		5 VAL A 332
VAL A 173
GLY A 175
ALA A 174
LEU A 369
 None
None
OMN  A 601 (-3.6A)
None
OMN  A 601 (-3.7A)
 1.06A 5jvzA-1sezA:
0.0		 5jvzA-1sezA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tqh CARBOXYLESTERASE
PRECURSOR

(Geobacillus
stearothermophilus) 		PF12146
(Hydrolase_4) 		5 LEU A 234
VAL A 113
GLY A  92
ALA A  91
LEU A  21
 None
 1.10A 5jvzA-1tqhA:
undetectable		 5jvzA-1tqhA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wdv HYPOTHETICAL PROTEIN
APE2540

(Aeropyrum
pernix) 		PF04073
(tRNA_edit) 		5 VAL A 101
LEU A 139
VAL A  98
GLY A 126
LEU A 132
 None
 1.01A 5jvzA-1wdvA:
undetectable		 5jvzA-1wdvA:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xm9 PLAKOPHILIN 1

(Homo sapiens) 		PF00514
(Arm) 		5 VAL A 619
LEU A 623
VAL A 591
GLY A 594
ALA A 595
 None
 1.04A 5jvzA-1xm9A:
undetectable		 5jvzA-1xm9A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zch HYPOTHETICAL
OXIDOREDUCTASE YCND

(Bacillus
subtilis) 		PF00881
(Nitroreductase) 		5 LEU A 240
VAL A 247
GLY A 103
SER A 106
LEU A 108
 None
 1.00A 5jvzA-1zchA:
undetectable		 5jvzA-1zchA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aiz OUTER MEMBRANE
PROTEIN P6

(Haemophilus
influenzae) 		PF00691
(OmpA) 		5 VAL P  90
LEU P  49
GLY P  68
ALA P 130
LEU P 132
 None
 1.06A 5jvzA-2aizP:
undetectable		 5jvzA-2aizP:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ayz SENSOR KINASE
PROTEIN RCSC

(Escherichia
coli) 		PF00072
(Response_reg) 		5 VAL A 899
LEU A 897
GLY A 857
ALA A 860
SER A 874
 None
 1.09A 5jvzA-2ayzA:
undetectable		 5jvzA-2ayzA:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cu5 CONSERVED
HYPOTHETICAL PROTEIN
TT1486

(Thermus
thermophilus) 		PF01894
(UPF0047) 		5 VAL A  34
LEU A 128
LEU A  36
GLY A 101
LEU A 103
 None
 0.91A 5jvzA-2cu5A:
undetectable		 5jvzA-2cu5A:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d4g HYPOTHETICAL PROTEIN
BSU11850

(Bacillus
subtilis) 		PF13563
(2_5_RNA_ligase2) 		5 LEU A  99
LEU A   7
ALA A  59
SER A  62
LEU A 167
 None
 1.05A 5jvzA-2d4gA:
undetectable		 5jvzA-2d4gA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gk9 PHOSPHATIDYLINOSITOL
-4-PHOSPHATE
5-KINASE, TYPE II,
GAMMA

(Homo sapiens) 		PF01504
(PIP5K) 		5 LEU A 126
TYR A 189
GLY A  54
ALA A  56
SER A  58
 None
 1.00A 5jvzA-2gk9A:
undetectable		 5jvzA-2gk9A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2huj LIN2004 PROTEIN

(Listeria
innocua) 		PF08807
(DUF1798) 		5 VAL A 110
LEU A 114
LEU A 107
ALA A  55
LEU A  72
 None
 1.04A 5jvzA-2hujA:
undetectable		 5jvzA-2hujA:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i34 ACID PHOSPHATASE

(Bacillus
anthracis) 		PF03767
(Acid_phosphat_B) 		5 VAL A  70
LEU A  71
GLY A 142
ALA A 143
LEU A 110
 None
 0.97A 5jvzA-2i34A:
undetectable		 5jvzA-2i34A:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2izp PUTATIVE MEMBRANE
ANTIGEN

(Burkholderia
pseudomallei) 		PF06511
(IpaD) 		5 VAL A1292
GLY A1295
ALA A1296
SER A1298
LEU A1300
 None
 1.00A 5jvzA-2izpA:
undetectable		 5jvzA-2izpA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j8k NP275-NP276

(Nostoc
punctiforme) 		PF00805
(Pentapeptide) 		5 LEU A 112
LEU A  77
GLY A  89
ALA A  90
LEU A  67
 None
 1.07A 5jvzA-2j8kA:
undetectable		 5jvzA-2j8kA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ols PHOSPHOENOLPYRUVATE
SYNTHASE

(Neisseria
meningitidis) 		PF00391
(PEP-utilizers)
PF01326
(PPDK_N)
PF02896
(PEP-utilizers_C) 		5 LEU A 100
VAL A 190
GLY A 189
ALA A 188
SER A 187
 None
 0.97A 5jvzA-2olsA:
0.3		 5jvzA-2olsA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ppl PANCREATIC
LIPASE-RELATED
PROTEIN 1

(Homo sapiens) 		PF00151
(Lipase)
PF01477
(PLAT) 		5 LEU A  25
VAL A 176
GLY A 178
ALA A 180
SER A 182
 None
None
CA  A 478 ( 4.9A)
None
None
 0.99A 5jvzA-2pplA:
undetectable		 5jvzA-2pplA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtk STE20-RELATED KINASE
ADAPTER PROTEIN
ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL B 121
LEU B 124
LEU B 214
GLY B 190
SER B 219
 None
 1.03A 5jvzA-2wtkB:
undetectable		 5jvzA-2wtkB:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x7j 2-SUCCINYL-5-ENOLPYR
UVYL-6-HYDROXY-3-CYC
LOHEXENE
-1-CARBOXYLATE
SYNTHASE

(Bacillus
subtilis) 		PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
PF16582
(TPP_enzyme_M_2) 		5 VAL A 437
LEU A 453
LEU A 467
GLY A 456
SER A 459
 None
None
None
TPP  A 601 (-3.4A)
TPP  A 601 (-4.6A)
 0.86A 5jvzA-2x7jA:
undetectable		 5jvzA-2x7jA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xec PUTATIVE MALEATE
ISOMERASE

(Nocardia
farcinica) 		no annotation 5 LEU A 158
VAL A 174
ALA A 178
SER A 180
LEU A 181
 None
 1.08A 5jvzA-2xecA:
undetectable		 5jvzA-2xecA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xn8 PUTATIVE CYTOCHROME
P450 125

(Mycobacterium
tuberculosis) 		PF00067
(p450) 		5 VAL A 313
LEU A 415
VAL A 267
GLY A 269
ALA A 268
 HEM  A1434 ( 4.9A)
None
None
HEM  A1434 (-3.3A)
HEM  A1434 (-3.5A)
 1.01A 5jvzA-2xn8A:
undetectable		 5jvzA-2xn8A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yxz THIAMIN-MONOPHOSPHAT
E KINASE

(Thermus
thermophilus) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		5 VAL A 134
LEU A 132
VAL A 105
GLY A 107
ALA A 108
 None
 1.09A 5jvzA-2yxzA:
undetectable		 5jvzA-2yxzA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aam ENDONUCLEASE IV

(Thermus
thermophilus) 		PF01261
(AP_endonuc_2) 		5 VAL A 107
VAL A 117
GLY A 120
ALA A 121
LEU A 136
 None
 1.09A 5jvzA-3aamA:
undetectable		 5jvzA-3aamA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dhn NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E

(Bacteroides
thetaiotaomicron) 		PF13460
(NAD_binding_10) 		5 VAL A  31
LEU A  25
VAL A  35
GLY A  11
ALA A  12
 None
 1.09A 5jvzA-3dhnA:
undetectable		 5jvzA-3dhnA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ele AMINO TRANSFERASE

([Eubacterium]
rectale) 		PF00155
(Aminotran_1_2) 		5 TYR A 219
GLY A 106
ALA A 107
SER A 110
LEU A 111
 PLP  A 500 (-4.4A)
PLP  A 500 (-3.6A)
PLP  A 500 (-3.2A)
None
None
 0.96A 5jvzA-3eleA:
undetectable		 5jvzA-3eleA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eyk HEMAGGLUTININ HA1
CHAIN
HEMAGGLUTININ HA2
CHAIN

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		5 LEU B  52
LEU A  42
GLY A 323
ALA A 321
SER A  38
 None
 1.05A 5jvzA-3eykB:
undetectable		 5jvzA-3eykB:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhf TRANSCRIPTIONAL
REGULATOR, LYSR
FAMILY

(Neisseria
meningitidis) 		no annotation 5 VAL B 237
LEU B 191
LEU B 239
GLY B 233
LEU B 253
 None
 1.07A 5jvzA-3hhfB:
undetectable		 5jvzA-3hhfB:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhg TRANSCRIPTIONAL
REGULATOR, LYSR
FAMILY

(Neisseria
meningitidis) 		PF00126
(HTH_1)
PF03466
(LysR_substrate) 		5 VAL A 237
LEU A 191
LEU A 239
GLY A 233
LEU A 253
 None
 1.07A 5jvzA-3hhgA:
undetectable		 5jvzA-3hhgA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i5p NUCLEOPORIN NUP170

(Saccharomyces
cerevisiae) 		PF03177
(Nucleoporin_C) 		5 LEU A1307
VAL A1268
GLY A1270
ALA A1269
LEU A1229
 None
 0.99A 5jvzA-3i5pA:
undetectable		 5jvzA-3i5pA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jr7 UNCHARACTERIZED EGV
FAMILY PROTEIN
COG1307

([Ruminococcus]
gnavus) 		PF02645
(DegV) 		5 VAL A 263
LEU A 230
LEU A 267
VAL A 179
GLY A 293
 None
 1.09A 5jvzA-3jr7A:
undetectable		 5jvzA-3jr7A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ktc XYLOSE ISOMERASE

(Pectobacterium
atrosepticum) 		PF01261
(AP_endonuc_2) 		6 VAL A  50
LEU A  47
LEU A  13
GLY A  73
ALA A  72
LEU A  69
 None
 1.47A 5jvzA-3ktcA:
undetectable		 5jvzA-3ktcA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3la2 GLOBAL NITROGEN
REGULATOR

(Nostoc sp. PCC
7120) 		PF00027
(cNMP_binding)
PF13545
(HTH_Crp_2) 		5 VAL A 108
LEU A 112
GLY A  76
SER A  79
LEU A  80
 None
None
AKG  A 224 (-3.1A)
None
None
 0.95A 5jvzA-3la2A:
undetectable		 5jvzA-3la2A:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nfq TRANSCRIPTION FACTOR
IWS1

(Saccharomyces
cerevisiae) 		PF08711
(Med26) 		5 VAL A  81
LEU A  85
VAL A  60
ALA A 105
LEU A 106
 None
 1.05A 5jvzA-3nfqA:
undetectable		 5jvzA-3nfqA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nix FLAVOPROTEIN/DEHYDRO
GENASE

(Cytophaga
hutchinsonii) 		PF01494
(FAD_binding_3) 		5 ARG A 105
LEU A  56
GLY A 307
ALA A 308
LEU A  48
 FAD  A 501 (-2.6A)
None
FAD  A 501 (-3.0A)
FAD  A 501 (-3.0A)
None
 0.98A 5jvzA-3nixA:
undetectable		 5jvzA-3nixA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oak TRANSCRIPTION FACTOR
IWS1

(Saccharomyces
cerevisiae) 		PF08711
(Med26) 		5 VAL A 221
LEU A 225
VAL A 200
ALA A 245
LEU A 246
 None
 1.08A 5jvzA-3oakA:
undetectable		 5jvzA-3oakA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p41 GERANYLTRANSTRANSFER
ASE

(Pseudomonas
protegens) 		PF00348
(polyprenyl_synt) 		5 LEU A 283
VAL A 189
GLY A 192
ALA A 193
LEU A  58
 None
 0.96A 5jvzA-3p41A:
undetectable		 5jvzA-3p41A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tfy N-ALPHA-ACETYLTRANSF
ERASE 50, NATE
CATALYTIC SUBUNIT

(Homo sapiens) 		PF00583
(Acetyltransf_1) 		5 VAL A  11
TYR A  36
TYR A  50
GLY A  57
ALA A  58
 None
 1.02A 5jvzA-3tfyA:
undetectable		 5jvzA-3tfyA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u4a JMB19063

(compost
metagenome) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		6 VAL A 518
LEU A 555
VAL A 386
GLY A 387
ALA A 390
LEU A 412
 None
 1.36A 5jvzA-3u4aA:
undetectable		 5jvzA-3u4aA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uw2 PHOSPHOGLUCOMUTASE/P
HOSPHOMANNOMUTASE
FAMILY PROTEIN

(Burkholderia
thailandensis) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		5 TYR A 338
TRP A 337
VAL A  82
ALA A  86
LEU A  91
 None
 1.06A 5jvzA-3uw2A:
undetectable		 5jvzA-3uw2A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v42 FOLLICULIN

(Homo sapiens) 		PF16692
(Folliculin_C) 		5 VAL A 439
VAL A 355
GLY A 357
SER A 360
LEU A 364
 None
 1.09A 5jvzA-3v42A:
undetectable		 5jvzA-3v42A:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxo CATALASE-PEROXIDASE

(Synechococcus
elongatus) 		PF00141
(peroxidase) 		5 VAL A 506
LEU A 510
LEU A 503
GLY A 529
ALA A 466
 None
 1.09A 5jvzA-3wxoA:
0.8		 5jvzA-3wxoA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zok 3-DEHYDROQUINATE
SYNTHASE

(Actinidia
chinensis) 		PF01761
(DHQ_synthase) 		5 LEU A 187
LEU A 229
ALA A 193
SER A 194
LEU A 196
 NAD  A1381 (-4.5A)
None
None
None
None
 0.99A 5jvzA-3zokA:
undetectable		 5jvzA-3zokA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4axv MPAA

(Vibrio
campbellii) 		PF04952
(AstE_AspA) 		6 VAL A 153
LEU A 229
TYR A 188
VAL A 162
ALA A 171
LEU A 170
 None
 1.45A 5jvzA-4axvA:
undetectable		 5jvzA-4axvA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b4o EPIMERASE FAMILY
PROTEIN SDR39U1

(Homo sapiens) 		PF01370
(Epimerase)
PF08338
(DUF1731) 		5 VAL A  56
LEU A 206
TRP A  41
GLY A   8
LEU A  16
 None
 1.09A 5jvzA-4b4oA:
undetectable		 5jvzA-4b4oA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c13 UDP-N-ACETYLMURAMOYL
-L-ALANYL-D-GLUTAMAT
E--L-LYSINE LIGASE

(Staphylococcus
aureus) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		5 TYR A 247
GLY A 216
ALA A 218
SER A 220
LEU A 221
 None
KCX  A 219 ( 4.5A)
KCX  A 219 ( 3.1A)
KCX  A 219 ( 4.3A)
None
 0.98A 5jvzA-4c13A:
undetectable		 5jvzA-4c13A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d2j FRUCTOSE-BISPHOSPHAT
E ALDOLASE

(Toxoplasma
gondii) 		PF00274
(Glycolytic) 		5 VAL A 258
LEU A 300
VAL A 238
GLY A 241
LEU A 288
 None
 1.02A 5jvzA-4d2jA:
undetectable		 5jvzA-4d2jA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dwq TRNA-SPLICING LIGASE
RTCB

(Pyrococcus
horikoshii) 		PF01139
(RtcB) 		5 VAL A 147
LEU A 148
GLY A 191
ALA A 192
LEU A 139
 None
 1.04A 5jvzA-4dwqA:
undetectable		 5jvzA-4dwqA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fwg TTC1975 PEPTIDASE

(Meiothermus
taiwanensis) 		PF05362
(Lon_C)
PF13654
(AAA_32) 		5 LEU A 310
VAL A 335
GLY A 333
ALA A 329
LEU A 330
 None
 1.01A 5jvzA-4fwgA:
undetectable		 5jvzA-4fwgA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hq1 PROBABLE RECEPTOR
PROTEIN KINASE TMK1

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8) 		5 VAL A 237
LEU A 239
VAL A 211
GLY A 233
LEU A 228
 None
 1.06A 5jvzA-4hq1A:
undetectable		 5jvzA-4hq1A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j9u TRK SYSTEM POTASSIUM
UPTAKE PROTEIN TRKH

(Vibrio
parahaemolyticus) 		PF02386
(TrkH) 		5 VAL A  79
GLY A  81
ALA A  83
SER A  85
LEU A  86
 None
 0.89A 5jvzA-4j9uA:
3.4		 5jvzA-4j9uA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jxb INVASION-ASSOCIATED
PROTEIN

(Mycobacterium
tuberculosis) 		PF00877
(NLPC_P60) 		5 VAL A 166
LEU A 167
LEU A 122
GLY A  95
LEU A  98
 None
 0.91A 5jvzA-4jxbA:
undetectable		 5jvzA-4jxbA:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kc5 RHIE PROTEIN

(Paraburkholderia
rhizoxinica) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 VAL A3299
LEU A3063
LEU A3301
TYR A3067
GLY A3413
 None
 0.93A 5jvzA-4kc5A:
undetectable		 5jvzA-4kc5A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kl0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Xanthomonas
oryzae) 		PF01156
(IU_nuc_hydro) 		5 VAL A 253
LEU A 227
GLY A 246
ALA A 245
LEU A 241
 None
 1.06A 5jvzA-4kl0A:
undetectable		 5jvzA-4kl0A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o1m ENOYL-ACYL CARRIER
REDUCTASE

(Toxoplasma
gondii) 		PF13561
(adh_short_C2) 		5 LEU A 286
VAL A 266
GLY A 268
ALA A 270
LEU A 274
 None
 0.99A 5jvzA-4o1mA:
undetectable		 5jvzA-4o1mA:
20.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ph9 PROSTAGLANDIN G/H
SYNTHASE 2

(Mus musculus) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		12 ARG A 121
VAL A 350
LEU A 353
TYR A 356
LEU A 360
TYR A 386
TRP A 388
VAL A 524
GLY A 527
ALA A 528
SER A 531
LEU A 532
 BOG  A 604 ( 3.7A)
IBP  A 601 (-4.3A)
IBP  A 601 ( 4.7A)
IBP  A 601 (-4.5A)
IBP  A 601 ( 4.7A)
IBP  A 601 (-4.8A)
None
IBP  A 601 ( 4.0A)
IBP  A 601 (-3.9A)
IBP  A 601 (-3.4A)
IBP  A 601 ( 3.3A)
IBP  A 601 ( 4.9A)
 0.47A 5jvzA-4ph9A:
64.0		 5jvzA-4ph9A:
99.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pj6 LEUCYL-CYSTINYL
AMINOPEPTIDASE

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		5 VAL A1006
LEU A 524
VAL A 967
GLY A 969
ALA A 968
 None
 1.00A 5jvzA-4pj6A:
undetectable		 5jvzA-4pj6A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rnw NADPH DEHYDROGENASE
1

(Saccharomyces
pastorianus) 		PF00724
(Oxidored_FMN) 		6 VAL A 384
LEU A 341
LEU A 386
VAL A 367
GLY A 369
ALA A 368
 None
 1.37A 5jvzA-4rnwA:
undetectable		 5jvzA-4rnwA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wb0 BROAD SPECIFICITY
AMINOTRANSFERASE

(Leishmania
mexicana) 		PF00155
(Aminotran_1_2) 		5 LEU A 121
TYR A  93
ALA A 252
SER A 270
LEU A 269
 None
 0.99A 5jvzA-4wb0A:
undetectable		 5jvzA-4wb0A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wuj GLYCOSIDE HYDROLASE
FAMILY 15, CELLULOSE
SIGNALING ASSOCIATED
PROTEIN ENVOY

(Trichoderma
reesei) 		PF13426
(PAS_9) 		5 VAL A 201
LEU A 102
LEU A 203
VAL A  74
GLY A  76
 FMN  A5201 (-4.2A)
None
None
None
None
 0.91A 5jvzA-4wujA:
undetectable		 5jvzA-4wujA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yei BETA1MUT

(synthetic
construct) 		PF00805
(Pentapeptide) 		5 LEU A 172
LEU A 137
GLY A 149
ALA A 150
LEU A 127
 None
 1.02A 5jvzA-4yeiA:
undetectable		 5jvzA-4yeiA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yxm DNA INTEGRITY
SCANNING PROTEIN
DISA

(Thermotoga
maritima) 		PF00633
(HHH)
PF02457
(DisA_N)
PF10635
(DisA-linker) 		5 LEU A  24
VAL A 126
GLY A  37
ALA A  38
SER A  72
 None
 1.05A 5jvzA-4yxmA:
undetectable		 5jvzA-4yxmA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zoy SQT1

(Chaetomium
thermophilum) 		PF00400
(WD40) 		5 LEU A 445
GLY A 396
ALA A 395
SER A 383
LEU A 384
 None
 1.07A 5jvzA-4zoyA:
undetectable		 5jvzA-4zoyA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a62 PUTATIVE ALPHA/BETA
HYDROLASE FOLD
PROTEIN

(Candidatus
Nitrososphaera
gargensis) 		PF00561
(Abhydrolase_1) 		5 ARG A 207
VAL A 213
VAL A 203
GLY A 205
SER A 209
 None
 0.98A 5jvzA-5a62A:
undetectable		 5jvzA-5a62A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cwv NUCLEOPORIN NUP192

(Chaetomium
thermophilum) 		PF11894
(Nup192) 		5 LEU A1665
LEU A1671
VAL A1646
ALA A1643
LEU A1722
 None
 1.06A 5jvzA-5cwvA:
undetectable		 5jvzA-5cwvA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dus ORF1A

(Middle East
respiratory
syndrome-related
coronavirus) 		PF01661
(Macro) 		5 VAL A 158
LEU A 162
GLY A 128
ALA A 127
LEU A 124
 None
None
APR  A 201 (-3.3A)
APR  A 201 (-3.9A)
None
 0.91A 5jvzA-5dusA:
undetectable		 5jvzA-5dusA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e2g BETA-LACTAMASE

(Burkholderia
cenocepacia) 		PF00144
(Beta-lactamase) 		5 LEU A 126
LEU A  91
VAL A 148
GLY A 151
LEU A 156
 None
 0.96A 5jvzA-5e2gA:
undetectable		 5jvzA-5e2gA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ecu CELLULASE

(Caldicellulosiruptor
saccharolyticus) 		PF00150
(Cellulase)
PF03424
(CBM_17_28) 		5 LEU A 344
LEU A 100
GLY A 329
ALA A 330
SER A 320
 None
 1.04A 5jvzA-5ecuA:
undetectable		 5jvzA-5ecuA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f4z EPOXIDE HYDROLASE

(Streptomyces
carzinostaticus) 		PF06441
(EHN) 		5 LEU A 328
GLY A 177
ALA A 178
SER A 181
LEU A 182
 None
 0.91A 5jvzA-5f4zA:
undetectable		 5jvzA-5f4zA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g1d SYNTENIN-1

(Rattus
norvegicus) 		PF00595
(PDZ) 		5 LEU A 131
VAL A 143
GLY A 128
ALA A 149
LEU A 119
 None
 1.07A 5jvzA-5g1dA:
undetectable		 5jvzA-5g1dA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i47 RIMK DOMAIN PROTEIN
ATP-GRASP

(Sphaerobacter
thermophilus) 		PF08443
(RimK) 		5 ARG A  25
VAL A   4
LEU A   6
ALA A 269
LEU A 273
 None
 1.10A 5jvzA-5i47A:
undetectable		 5jvzA-5i47A:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5idt GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E

(Burkholderia
vietnamiensis) 		PF00483
(NTP_transferase) 		5 LEU A  28
LEU A  68
GLY A  11
ALA A  10
SER A  56
 None
None
THM  A 301 (-2.9A)
None
None
 1.06A 5jvzA-5idtA:
undetectable		 5jvzA-5idtA:
20.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ikr PROSTAGLANDIN G/H
SYNTHASE 2

(Homo sapiens) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		12 ARG A 120
VAL A 349
LEU A 352
TYR A 355
LEU A 359
TYR A 385
TRP A 387
VAL A 523
GLY A 526
ALA A 527
SER A 530
LEU A 531
 ID8  A 601 ( 4.4A)
ID8  A 601 (-3.9A)
ID8  A 601 (-4.1A)
ID8  A 601 (-3.8A)
None
ID8  A 601 ( 3.5A)
COH  A 602 (-4.5A)
ID8  A 601 (-3.6A)
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-2.7A)
ID8  A 601 (-3.5A)
 0.61A 5jvzA-5ikrA:
62.5		 5jvzA-5ikrA:
87.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ipx ORF49 PROTEIN

(Human
gammaherpesvirus
8) 		PF04793
(Herpes_BBRF1) 		5 ARG A 160
VAL A 153
GLY A 154
ALA A 155
LEU A 159
 SO4  A 402 (-4.1A)
None
None
None
None
 1.00A 5jvzA-5ipxA:
undetectable		 5jvzA-5ipxA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jry NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE

(Burkholderia
multivorans) 		PF00171
(Aldedh) 		5 LEU A 301
TYR A 376
VAL A 288
ALA A 385
LEU A 365
 None
 1.10A 5jvzA-5jryA:
undetectable		 5jvzA-5jryA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jvb PHOSPHONATE ABC
TRANSPORTER,
PERIPLASMIC
PHOSPHONATE-BINDING
PROTEIN

(Trichodesmium
erythraeum) 		no annotation 6 LEU A 185
TYR A  55
VAL A 157
GLY A 126
SER A 133
LEU A 177
 None
2PO  A 301 (-4.5A)
None
None
2PO  A 301 ( 4.4A)
None
 1.29A 5jvzA-5jvbA:
undetectable		 5jvzA-5jvbA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kdx METALLOPEPTIDASE

(Pseudomonas
aeruginosa) 		PF13402
(Peptidase_M60) 		5 VAL A 162
LEU A 247
GLY A 198
ALA A 197
LEU A 194
 None
 1.10A 5jvzA-5kdxA:
0.7		 5jvzA-5kdxA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lb8 ATP-DEPENDENT DNA
HELICASE Q5

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF16124
(RecQ_Zn_bind) 		5 LEU A  93
GLY A  55
ALA A  56
SER A  59
LEU A  60
 None
 0.78A 5jvzA-5lb8A:
undetectable		 5jvzA-5lb8A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lfn CHONDROADHERIN

(Homo sapiens) 		PF00560
(LRR_1)
PF01462
(LRRNT)
PF13855
(LRR_8) 		5 LEU A  82
LEU A 101
VAL A  90
ALA A  94
SER A  70
 None
 1.07A 5jvzA-5lfnA:
undetectable		 5jvzA-5lfnA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mpd 26S PROTEASOME
REGULATORY SUBUNIT
RPN7

(Saccharomyces
cerevisiae) 		PF01399
(PCI)
PF10602
(RPN7) 		5 LEU R 243
LEU R 172
TYR R 321
GLY R 215
LEU R 191
 None
 1.03A 5jvzA-5mpdR:
undetectable		 5jvzA-5mpdR:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n3u PHYCOCYANOBILIN
LYASE SUBUNIT ALPHA

(Nostoc sp. PCC
7120) 		no annotation 5 LEU A  59
VAL A 104
ALA A 108
SER A 111
LEU A 112
 None
 0.87A 5jvzA-5n3uA:
undetectable		 5jvzA-5n3uA:
9.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ohs -

(-) 		no annotation 5 LEU A 450
VAL A 469
GLY A 472
ALA A 473
SER A 476
 None
 1.04A 5jvzA-5ohsA:
undetectable		 5jvzA-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tp4 AMIDASE,
HYDANTOINASE/CARBAMO
YLASE FAMILY

(Burkholderia
ambifaria) 		PF01546
(Peptidase_M20) 		5 ARG A  93
VAL A  97
LEU A 101
TRP A  49
ALA A  20
 EDO  A 506 (-3.6A)
None
None
None
EDO  A 506 ( 4.9A)
 1.09A 5jvzA-5tp4A:
undetectable		 5jvzA-5tp4A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ue0 CT622 PROTEIN

(Chlamydia
trachomatis) 		no annotation 5 LEU A 396
LEU A 403
VAL A 440
ALA A 443
LEU A 356
 None
 1.09A 5jvzA-5ue0A:
undetectable		 5jvzA-5ue0A:
8.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ver KYNURENINE--OXOGLUTA
RATE TRANSAMINASE 3

(Mus musculus) 		no annotation 5 TYR A 250
GLY A 134
ALA A 135
SER A 138
LEU A 139
 PLP  A 701 (-4.1A)
PLP  A 701 (-3.2A)
PLP  A 701 (-3.4A)
None
None
 1.07A 5jvzA-5verA:
undetectable		 5jvzA-5verA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vym BETA-GALACTOSIDASE
BGAB

(Bifidobacterium
adolescentis) 		PF08532
(Glyco_hydro_42M) 		6 LEU A 119
LEU A  77
TYR A 107
GLY A 109
ALA A 110
LEU A  69
 None
 1.32A 5jvzA-5vymA:
undetectable		 5jvzA-5vymA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wml -

(-) 		no annotation 5 TYR A 275
GLY A 167
ALA A 168
SER A 171
LEU A 172
 PMP  A 501 (-4.3A)
PMP  A 501 (-3.4A)
PMP  A 501 (-3.6A)
None
None
 1.08A 5jvzA-5wmlA:
undetectable		 5jvzA-5wmlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wu3 SPECKLE TARGETED
PIP5K1A-REGULATED
POLY(A) POLYMERASE

(Homo sapiens) 		PF03828
(PAP_assoc) 		6 LEU A 422
LEU A 437
VAL A 559
GLY A 561
ALA A 560
LEU A 507
 None
 1.26A 5jvzA-5wu3A:
0.0		 5jvzA-5wu3A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wu6 SPECKLE TARGETED
PIP5K1A-REGULATED
POLY(A) POLYMERASE

(Homo sapiens) 		PF00076
(RRM_1)
PF03828
(PAP_assoc) 		6 LEU A 422
LEU A 437
VAL A 559
GLY A 561
ALA A 560
LEU A 507
 None
 1.27A 5jvzA-5wu6A:
undetectable		 5jvzA-5wu6A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xil PUTATIVE PROLYL-TRNA
SYNTHETASE

(Leishmania
major) 		no annotation 5 VAL A 434
LEU A 303
VAL A 463
GLY A 476
ALA A 477
 None
 1.08A 5jvzA-5xilA:
undetectable		 5jvzA-5xilA:
8.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6k POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE

(Acinetobacter
baumannii) 		no annotation 5 LEU A 380
LEU A 417
VAL A 445
GLY A 447
SER A 451
 None
 1.06A 5jvzA-6d6kA:
undetectable		 5jvzA-6d6kA:
9.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6en4 SPLICING FACTOR 3B
SUBUNIT 1

(Homo sapiens) 		no annotation 5 LEU C1098
VAL C1143
GLY C1146
SER C1150
LEU C1151
 None
 1.06A 5jvzA-6en4C:
undetectable		 5jvzA-6en4C:
10.97