SIMILAR PATTERNS OF AMINO ACIDS FOR 5JSD_C_1GNC608

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a3g BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE

(Escherichia
coli) 		PF01063
(Aminotran_4) 		3 THR A 117
SER A 116
TYR A 115
 None
 0.62A 5jsdC-1a3gA:
0.0		 5jsdC-1a3gA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens) 		PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b)
PF03173
(CHB_HEX)
PF03174
(CHB_HEX_C) 		3 THR A 846
SER A 845
TYR A 844
 None
 0.84A 5jsdC-1c7tA:
0.8		 5jsdC-1c7tA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fh5 MONOCLONAL ANTIBODY
MAK33

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 THR H  25
SER H  28
TYR H  29
 None
 0.87A 5jsdC-1fh5H:
0.0		 5jsdC-1fh5H:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h0d ANTIBODY FAB
FRAGMENT, HEAVY
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 THR B  28
SER B  31
TYR B  32
 None
 0.85A 5jsdC-1h0dB:
0.0		 5jsdC-1h0dB:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h5b MURINE T CELL
RECEPTOR (TCR)
VALPHA DOMAIN

(Mus musculus) 		PF07686
(V-set) 		3 THR A  72
SER A  71
TYR A  70
 None
 0.85A 5jsdC-1h5bA:
0.0		 5jsdC-1h5bA:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h6h NEUTROPHIL CYTOSOL
FACTOR 4

(Homo sapiens) 		PF00787
(PX) 		3 THR A  47
SER A  51
TYR A  53
 None
 0.79A 5jsdC-1h6hA:
0.0		 5jsdC-1h6hA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hzo BETA-LACTAMASE

(Proteus
vulgaris) 		PF13354
(Beta-lactamase2) 		3 THR A 181
SER A 182
TYR A 264
 None
 0.69A 5jsdC-1hzoA:
0.0		 5jsdC-1hzoA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jhl IGG1-KAPPA D11.15 FV
(HEAVY CHAIN)

(Mus musculus) 		PF07686
(V-set) 		3 THR H  28
SER H  31
TYR H  32
 None
 0.83A 5jsdC-1jhlH:
2.7		 5jsdC-1jhlH:
10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m33 BIOH PROTEIN

(Escherichia
coli) 		PF00561
(Abhydrolase_1) 		3 THR A 104
SER A 107
TYR A 203
 None
 0.83A 5jsdC-1m33A:
0.9		 5jsdC-1m33A:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pby QUINOHEMOPROTEIN
AMINE DEHYDROGENASE
40 KDA SUBUNIT

(Paracoccus
denitrificans) 		no annotation 3 THR B 115
SER B 101
TYR B  99
 None
 0.87A 5jsdC-1pbyB:
undetectable		 5jsdC-1pbyB:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pvj PYROGENIC EXOTOXIN B

(Streptococcus
pyogenes) 		PF01640
(Peptidase_C10)
PF13734
(Inhibitor_I69) 		3 THR A 105
SER A 104
TYR A 103
 None
 0.65A 5jsdC-1pvjA:
undetectable		 5jsdC-1pvjA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qfw ANTIBODY (ANTI ALPHA
SUBUNIT) (HEAVY
CHAIN)

(Mus musculus) 		PF07686
(V-set) 		3 THR H  28
SER H  31
TYR H  32
 None
 0.77A 5jsdC-1qfwH:
undetectable		 5jsdC-1qfwH:
10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qle HEAVY CHAIN ANTIBODY
FV FRAGMENT

(Mus musculus) 		PF07686
(V-set) 		3 THR H  28
SER H  31
TYR H  32
 None
 0.86A 5jsdC-1qleH:
2.5		 5jsdC-1qleH:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1upx HYDROXYLAMINE
REDUCTASE

(Desulfovibrio
desulfuricans) 		PF03063
(Prismane) 		3 THR A 533
SER A 534
TYR A 408
 None
 0.83A 5jsdC-1upxA:
undetectable		 5jsdC-1upxA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v0b CELL DIVISION
CONTROL PROTEIN 2
HOMOLOG

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		3 THR A 180
SER A 179
TYR A 178
 None
 0.75A 5jsdC-1v0bA:
undetectable		 5jsdC-1v0bA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xc6 BETA-GALACTOSIDASE

(Penicillium sp.) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		3 THR A 491
SER A 490
TYR A 489
 None
 0.80A 5jsdC-1xc6A:
undetectable		 5jsdC-1xc6A:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xru 4-DEOXY-L-THREO-5-HE
XOSULOSE-URONATE
KETOL-ISOMERASE

(Escherichia
coli) 		PF04962
(KduI) 		3 THR A 192
SER A 246
TYR A 205
 None
 0.80A 5jsdC-1xruA:
1.9		 5jsdC-1xruA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ybf AMP NUCLEOSIDASE

(Bacteroides
thetaiotaomicron) 		PF01048
(PNP_UDP_1) 		3 THR A 190
SER A 122
TYR A 125
 None
 0.86A 5jsdC-1ybfA:
undetectable		 5jsdC-1ybfA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yqf HYPOTHETICAL PROTEIN
LMAJ011689

(Leishmania
major) 		PF02330
(MAM33) 		3 THR A  74
SER A  73
TYR A  72
 None
 0.87A 5jsdC-1yqfA:
undetectable		 5jsdC-1yqfA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2emp ZINC FINGER PROTEIN
347

(Homo sapiens) 		PF00096
(zf-C2H2) 		3 THR A  29
SER A  26
TYR A  25
 None
 0.74A 5jsdC-2empA:
undetectable		 5jsdC-2empA:
6.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g28 PYRUVATE
DEHYDROGENASE E1
COMPONENT

(Escherichia
coli) 		PF00456
(Transketolase_N) 		3 THR A 494
SER A 493
TYR A 696
 None
 0.79A 5jsdC-2g28A:
undetectable		 5jsdC-2g28A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gki NUCLEASE

(Mus musculus) 		PF07686
(V-set) 		3 THR A  50
SER A  53
TYR A  54
 None
 0.82A 5jsdC-2gkiA:
undetectable		 5jsdC-2gkiA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		3 THR A 247
SER A 248
TYR A  90
 None
 0.73A 5jsdC-2h8hA:
1.7		 5jsdC-2h8hA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o36 THIMET
OLIGOPEPTIDASE

(Homo sapiens) 		PF01432
(Peptidase_M3) 		3 THR A 527
SER A 529
TYR A 359
 None
 0.84A 5jsdC-2o36A:
undetectable		 5jsdC-2o36A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p62 HYPOTHETICAL PROTEIN
PH0156

(Pyrococcus
horikoshii) 		PF11536
(DUF3226) 		3 THR A  12
SER A 205
TYR A 208
 None
 0.87A 5jsdC-2p62A:
undetectable		 5jsdC-2p62A:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xa8 OMALIZUMAB HEAVY
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 THR H  53
SER H  34
TYR H  33
 None
 0.88A 5jsdC-2xa8H:
2.6		 5jsdC-2xa8H:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zjs FAB56 (HEAVY CHAIN)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 THR H  28
SER H  31
TYR H  32
 None
 0.80A 5jsdC-2zjsH:
2.7		 5jsdC-2zjsH:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zux YESW PROTEIN

(Bacillus
subtilis) 		no annotation 3 THR A 395
SER A 394
TYR A 393
 None
 0.77A 5jsdC-2zuxA:
2.3		 5jsdC-2zuxA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zuy YESX PROTEIN

(Bacillus
subtilis) 		PF01839
(FG-GAP) 		3 THR A 362
SER A 361
TYR A 360
 None
 0.81A 5jsdC-2zuyA:
undetectable		 5jsdC-2zuyA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bfg CLASS A
BETA-LACTAMASE SED1

(Citrobacter
sedlakii) 		PF13354
(Beta-lactamase2) 		3 THR A 181
SER A 182
TYR A 264
 None
 0.71A 5jsdC-3bfgA:
undetectable		 5jsdC-3bfgA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bwh CUCURMOSIN

(Cucurbita
moschata) 		PF00161
(RIP) 		3 THR A  76
SER A  75
TYR A  74
 None
 0.79A 5jsdC-3bwhA:
undetectable		 5jsdC-3bwhA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c6a TERMINASE LARGE
SUBUNIT

(Escherichia
virus RB49) 		PF17289
(Terminase_6C) 		3 THR A 430
SER A 428
TYR A 407
 None
 0.87A 5jsdC-3c6aA:
undetectable		 5jsdC-3c6aA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fo8 TAIL SHEATH PROTEIN
GP18

(Escherichia
virus T4) 		PF17481
(Phage_sheath_1N) 		3 THR D 297
SER D 277
TYR D 279
 None
 0.87A 5jsdC-3fo8D:
undetectable		 5jsdC-3fo8D:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gsz RNA-DIRECTED RNA
POLYMERASE

(Hepacivirus C) 		PF00998
(RdRP_3) 		3 THR A  40
SER A  39
TYR A  38
 None
 0.85A 5jsdC-3gszA:
undetectable		 5jsdC-3gszA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i09 PERIPLASMIC
BRANCHED-CHAIN AMINO
ACID-BINDING PROTEIN

(Burkholderia
mallei) 		PF13458
(Peripla_BP_6) 		3 THR A 311
SER A 308
TYR A 307
 None
 0.83A 5jsdC-3i09A:
1.6		 5jsdC-3i09A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i58 O-METHYLTRANSFERASE

(Streptomyces
carzinostaticus) 		PF00891
(Methyltransf_2) 		3 THR A 130
SER A 131
TYR A 124
 None
 0.58A 5jsdC-3i58A:
undetectable		 5jsdC-3i58A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mbe TCR 21.3 ALPHA CHAIN

(Mus musculus) 		PF07686
(V-set)
PF09291
(DUF1968) 		3 THR C  88
SER C  87
TYR C  86
 None
 0.84A 5jsdC-3mbeC:
undetectable		 5jsdC-3mbeC:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mbf FRUCTOSE-BISPHOSPHAT
E ALDOLASE

(Encephalitozoon
cuniculi) 		PF00274
(Glycolytic) 		3 THR A 226
SER A 227
TYR A 188
 None
 0.75A 5jsdC-3mbfA:
undetectable		 5jsdC-3mbfA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mkr COATOMER SUBUNIT
EPSILON

(Bos taurus) 		PF04733
(Coatomer_E) 		3 THR A 215
SER A  30
TYR A  31
 None
 0.87A 5jsdC-3mkrA:
undetectable		 5jsdC-3mkrA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ogg BOTULINUM NEUROTOXIN
TYPE D

(Clostridium
botulinum) 		PF07951
(Toxin_R_bind_C)
PF07953
(Toxin_R_bind_N) 		3 THR A 999
SER A 990
TYR A 989
 None
 0.86A 5jsdC-3oggA:
undetectable		 5jsdC-3oggA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ogr BETA-GALACTOSIDASE

(Trichoderma
reesei) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		3 THR A 488
SER A 487
TYR A 486
 None
 0.83A 5jsdC-3ogrA:
undetectable		 5jsdC-3ogrA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qiu TCR 226 ALPHA CHAIN

(Mus musculus) 		PF07686
(V-set)
PF09291
(DUF1968) 		3 THR C  70
SER C  69
TYR C  68
 None
 0.85A 5jsdC-3qiuC:
undetectable		 5jsdC-3qiuC:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qph TRMB, A GLOBAL
TRANSCRIPTION
REGULATOR

(Pyrococcus
furiosus) 		PF01978
(TrmB)
PF11495
(Regulator_TrmB) 		3 THR A  40
SER A  39
TYR A  72
 None
 0.88A 5jsdC-3qphA:
undetectable		 5jsdC-3qphA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rle GOLGI
REASSEMBLY-STACKING
PROTEIN 2

(Homo sapiens) 		PF04495
(GRASP55_65) 		3 THR A 168
SER A 133
TYR A 135
 None
 0.75A 5jsdC-3rleA:
undetectable		 5jsdC-3rleA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ta6 TRIOSEPHOSPHATE
ISOMERASE

(Mycobacterium
tuberculosis) 		PF00121
(TIM) 		3 THR A  65
SER A  94
TYR A  95
 None
 0.85A 5jsdC-3ta6A:
undetectable		 5jsdC-3ta6A:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3teu FIBCON

(-) 		PF00041
(fn3) 		3 THR A  35
SER A  71
TYR A  73
 None
 0.87A 5jsdC-3teuA:
undetectable		 5jsdC-3teuA:
8.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zny CTX-M-12A ENZYME

(Klebsiella
pneumoniae) 		PF13354
(Beta-lactamase2) 		3 THR A 181
SER A 182
TYR A 264
 None
 0.77A 5jsdC-3znyA:
undetectable		 5jsdC-3znyA:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a5w COMPLEMENT C5

(Homo sapiens) 		PF00207
(A2M)
PF01759
(NTR)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2) 		3 THR A1511
SER A1510
TYR A1509
 None
 0.87A 5jsdC-4a5wA:
undetectable		 5jsdC-4a5wA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b93 ANKYRIN REPEAT
DOMAIN-CONTAINING
PROTEIN 27

(Homo sapiens) 		PF12796
(Ank_2)
PF13857
(Ank_5) 		3 THR B 740
SER B 741
TYR B 667
 None
 0.73A 5jsdC-4b93B:
undetectable		 5jsdC-4b93B:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cag POLYSACCHARIDE LYASE
FAMILY 11 PROTEIN

(Bacillus
licheniformis) 		PF01839
(FG-GAP) 		3 THR A 365
SER A 364
TYR A 363
 None
 0.86A 5jsdC-4cagA:
undetectable		 5jsdC-4cagA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dws CHI2

(Yersinia
entomophaga) 		PF00704
(Glyco_hydro_18) 		3 THR A 132
SER A 130
TYR A 113
 MLZ  A 518 ( 4.6A)
None
None
 0.84A 5jsdC-4dwsA:
undetectable		 5jsdC-4dwsA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ezi UNCHARACTERIZED
PROTEIN

(Legionella
pneumophila) 		no annotation 3 THR A 257
SER A 254
TYR A 253
 None
 0.88A 5jsdC-4eziA:
undetectable		 5jsdC-4eziA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fe9 OUTER MEMBRANE
PROTEIN SUSF

(Bacteroides
thetaiotaomicron) 		PF16411
(SusF_SusE)
PF17142
(DUF5115) 		3 THR A 309
SER A 370
TYR A 368
 None
 0.83A 5jsdC-4fe9A:
undetectable		 5jsdC-4fe9A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gdn PROTEIN FLP

(Staphylococcus
aureus) 		PF00144
(Beta-lactamase) 		3 THR A 271
SER A 270
TYR A  92
 None
 0.84A 5jsdC-4gdnA:
undetectable		 5jsdC-4gdnA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gr5 NON-RIBOSOMAL
PEPTIDE SYNTHETASE

(Streptomyces
lydicus) 		PF00501
(AMP-binding)
PF03621
(MbtH) 		3 THR A 175
SER A 176
TYR A 190
 None
 0.70A 5jsdC-4gr5A:
undetectable		 5jsdC-4gr5A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hjj ANTI-IL12 ANTI-IL18
DFAB HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 THR H 153
SER H 156
TYR H 157
 None
 0.74A 5jsdC-4hjjH:
undetectable		 5jsdC-4hjjH:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iug BETA-GALACTOSIDASE A

(Aspergillus
oryzae) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		3 THR A 488
SER A 487
TYR A 486
 None
 0.84A 5jsdC-4iugA:
undetectable		 5jsdC-4iugA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		3 THR A 247
SER A 248
TYR A  90
 None
 0.74A 5jsdC-4k11A:
undetectable		 5jsdC-4k11A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ki5 MURINE MONOCLONAL
G99 FAB HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 THR E  28
SER E  31
TYR E  32
 THR  E  28 ( 0.8A)
SER  E  31 ( 0.0A)
TYR  E  32 ( 1.3A)
 0.84A 5jsdC-4ki5E:
undetectable		 5jsdC-4ki5E:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4leh BILE ACID 7-ALPHA
DEHYDRATASE, BAIE

([Clostridium]
scindens) 		PF13577
(SnoaL_4) 		3 THR A  55
SER A  56
TYR A  57
 None
None
SO4  A 203 (-4.6A)
 0.85A 5jsdC-4lehA:
undetectable		 5jsdC-4lehA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lri MSL-109 HEAVY CHAIN

(Homo sapiens) 		no annotation 3 THR P  28
SER P  30
TYR P  32
 None
 0.75A 5jsdC-4lriP:
undetectable		 5jsdC-4lriP:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nmw PIMELYL-[ACYL-CARRIE
R PROTEIN] METHYL
ESTER ESTERASE

(Salmonella
enterica) 		PF00561
(Abhydrolase_1) 		3 THR A 104
SER A 107
TYR A 203
 None
 0.80A 5jsdC-4nmwA:
undetectable		 5jsdC-4nmwA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4odh CAP256-VRC26.UCA
HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 THR H  28
SER H  31
TYR H  32
 None
 0.77A 5jsdC-4odhH:
undetectable		 5jsdC-4odhH:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qf1 INFERRED UNMUTATED
ANCESTOR (UA) OF
ANTI-HIV ANTIBODY
CH59

(Homo sapiens) 		no annotation 3 THR L  91
SER L  90
TYR L  89
 None
 0.81A 5jsdC-4qf1L:
undetectable		 5jsdC-4qf1L:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u8t ZYRO0G01672P

(Zygosaccharomyces
rouxii) 		PF04146
(YTH) 		3 THR A 203
SER A 202
TYR A 260
 G  O  -1 ( 3.5A)
None
None
 0.81A 5jsdC-4u8tA:
undetectable		 5jsdC-4u8tA:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wxu MYOCILIN

(Homo sapiens) 		PF02191
(OLF) 		3 THR A 394
SER A 393
TYR A 392
 None
 0.70A 5jsdC-4wxuA:
undetectable		 5jsdC-4wxuA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xh3 ACTIN-BINDING
PROTEIN ANILLIN

(Homo sapiens) 		PF08174
(Anillin) 		3 THR A 140
SER A 139
TYR A 121
 None
 0.84A 5jsdC-4xh3A:
undetectable		 5jsdC-4xh3A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ymk ACYL-COA DESATURASE
1

(Mus musculus) 		PF00487
(FA_desaturase) 		3 THR A 317
SER A 305
TYR A 304
 None
 0.87A 5jsdC-4ymkA:
undetectable		 5jsdC-4ymkA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z0b ANTIBODY HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 THR H  28
SER H  31
TYR H  32
 None
 0.71A 5jsdC-4z0bH:
undetectable		 5jsdC-4z0bH:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zso ANTIBODY HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 THR B  28
SER B  31
TYR B  32
 None
 0.82A 5jsdC-4zsoB:
undetectable		 5jsdC-4zsoB:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zyo ACYL-COA DESATURASE

(Homo sapiens) 		no annotation 3 THR A 321
SER A 309
TYR A 308
 None
 0.79A 5jsdC-4zyoA:
undetectable		 5jsdC-4zyoA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b3j FAB, HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 THR E  28
SER E  31
TYR E  32
 None
 0.81A 5jsdC-5b3jE:
undetectable		 5jsdC-5b3jE:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bop NANOBODY

(Lama glama) 		PF07686
(V-set) 		3 THR A  54
SER A  52
TYR A  32
 None
 0.75A 5jsdC-5bopA:
undetectable		 5jsdC-5bopA:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bz4 BETA-KETOTHIOLASE

(Mycolicibacterium
smegmatis) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		3 THR A 128
SER A 127
TYR A 126
 None
 0.79A 5jsdC-5bz4A:
undetectable		 5jsdC-5bz4A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dq9 S55-3 FAB (IGG2B)
HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 THR A  28
SER A  30
TYR A  32
 None
 0.82A 5jsdC-5dq9A:
undetectable		 5jsdC-5dq9A:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5flw EXO-BETA-1,3-GALACTA
NASE

(Bifidobacterium
bifidum) 		PF04616
(Glyco_hydro_43) 		3 THR A 219
SER A 218
TYR A 217
 None
 0.79A 5jsdC-5flwA:
undetectable		 5jsdC-5flwA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gs2 ANTI-REPEBODY

(Mus musculus) 		PF07686
(V-set) 		3 THR D  28
SER D  31
TYR D  32
 None
 0.77A 5jsdC-5gs2D:
undetectable		 5jsdC-5gs2D:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hp7 REACTIVE
INTERMEDIATE
DEAMINASE A,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF01042
(Ribonuc_L-PSP) 		3 THR A 138
SER A 166
TYR A 168
 None
 0.75A 5jsdC-5hp7A:
undetectable		 5jsdC-5hp7A:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ifh HEAVY CHAIN OF THE
FAB FRAGMENT FROM
BCR DERIVED FROM THE
P11475 CLL CLONE

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 THR H  28
SER H  31
TYR H  32
 None
 0.69A 5jsdC-5ifhH:
undetectable		 5jsdC-5ifhH:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ihr PROBABLE
BETA-GALACTOSIDASE A

(Aspergillus
niger) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		3 THR A 488
SER A 487
TYR A 486
 None
 0.79A 5jsdC-5ihrA:
undetectable		 5jsdC-5ihrA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iml NANOBODY

(Camelidae) 		PF07686
(V-set) 		3 THR B  27
SER B  30
TYR B  31
 None
 0.74A 5jsdC-5imlB:
undetectable		 5jsdC-5imlB:
9.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ivo BC2-NANOBODY

(Vicugna pacos) 		PF07686
(V-set) 		3 THR A  23
SER A  21
TYR A  80
 None
 0.86A 5jsdC-5ivoA:
undetectable		 5jsdC-5ivoA:
10.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jse PHIAB6 TAILSPIKE

(unidentified
phage) 		PF12708
(Pectate_lyase_3) 		3 THR A 301
SER A 331
TYR A 333
 1GN  A 608 (-3.8A)
1GN  A 608 (-2.6A)
BGC  A 604 (-3.5A)
 0.05A 5jsdC-5jseA:
53.2		 5jsdC-5jseA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mpd 26S PROTEASOME
REGULATORY SUBUNIT
RPN7

(Saccharomyces
cerevisiae) 		PF01399
(PCI)
PF10602
(RPN7) 		3 THR R 244
SER R 248
TYR R 252
 None
 0.84A 5jsdC-5mpdR:
undetectable		 5jsdC-5mpdR:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5my0 FATTY ACID SYNTHASE

(Mus musculus) 		no annotation 3 THR B  74
SER B 131
TYR B 130
 None
 0.79A 5jsdC-5my0B:
undetectable		 5jsdC-5my0B:
7.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n2k BRIAKINUMAB FAB
HEAVY CHAIN

(Homo sapiens) 		no annotation 3 THR B  28
SER B  31
TYR B  32
 None
 0.82A 5jsdC-5n2kB:
undetectable		 5jsdC-5n2kB:
7.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ov3 RETINOBLASTOMA-BINDI
NG PROTEIN 5

(Mus musculus) 		no annotation 3 THR A 252
SER A 270
TYR A 277
 None
 0.87A 5jsdC-5ov3A:
undetectable		 5jsdC-5ov3A:
6.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ovn POL PROTEIN

(Feline
immunodeficiency
virus) 		no annotation 3 THR B 393
SER B 394
TYR B 417
 None
 0.84A 5jsdC-5ovnB:
undetectable		 5jsdC-5ovnB:
7.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tul TETRACYCLINE
DESTRUCTASE TET(55)

(uncultured
bacterium) 		PF01494
(FAD_binding_3) 		3 THR A  39
SER A  38
TYR A 123
 None
 0.88A 5jsdC-5tulA:
undetectable		 5jsdC-5tulA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u68 MPE8

(Homo sapiens) 		PF07686
(V-set) 		3 THR E  47
SER E  50
TYR E  51
 None
 0.80A 5jsdC-5u68E:
undetectable		 5jsdC-5u68E:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vg1 CHITINASE

(Jonesia
denitrificans) 		PF03067
(LPMO_10) 		3 THR A  72
SER A  74
TYR A 165
 None
 0.82A 5jsdC-5vg1A:
undetectable		 5jsdC-5vg1A:
11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vpq BETA-LACTAMASE

(Paraburkholderia
phymatum) 		PF13354
(Beta-lactamase2) 		3 THR A 170
SER A 171
TYR A 253
 None
 0.72A 5jsdC-5vpqA:
undetectable		 5jsdC-5vpqA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wym ANTI-CONNEXIN26
SCFV,IG HEAVY
CHAIN,LINKER,ANTI-CO
NNEXIN26 SCFV,IG
LIGHT CHAIN

(Homo sapiens;
synthetic
construct) 		no annotation 3 THR A  28
SER A  31
TYR A  32
 None
 0.86A 5jsdC-5wymA:
undetectable		 5jsdC-5wymA:
8.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp. 598K) 		PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF16990
(CBM_35)
PF17137
(DUF5110) 		3 THR A 205
SER A 204
TYR A 166
 None
 0.83A 5jsdC-5x7sA:
undetectable		 5jsdC-5x7sA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xj3 IPILIMUMAB-VH

(Homo sapiens) 		no annotation 3 THR A  28
SER A  31
TYR A  32
 None
 0.87A 5jsdC-5xj3A:
undetectable		 5jsdC-5xj3A:
8.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zq6 SIDE

(Legionella
pneumophila) 		no annotation 3 THR A 818
SER A 817
TYR A 858
 None
 0.87A 5jsdC-5zq6A:
undetectable		 5jsdC-5zq6A:
8.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6amj CAT192 FAB HEAVY
CHAIN

(Homo sapiens) 		no annotation 3 THR H  28
SER H  31
TYR H  32
 None
 0.83A 5jsdC-6amjH:
undetectable		 5jsdC-6amjH:
7.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cl5 TAIL FIBER PROTEIN

(Pseudomonas
aeruginosa) 		no annotation 3 THR A 506
SER A 510
TYR A 512
 None
 0.86A 5jsdC-6cl5A:
undetectable		 5jsdC-6cl5A:
8.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fe4 NB113

(Vicugna pacos) 		no annotation 3 THR F  28
SER F  31
TYR F  32
 None
 0.86A 5jsdC-6fe4F:
undetectable		 5jsdC-6fe4F:
7.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6h20 -

(-) 		no annotation 3 THR A 177
SER A  71
TYR A 326
 None
 0.81A 5jsdC-6h20A:
undetectable		 5jsdC-6h20A:
undetectable