SIMILAR PATTERNS OF AMINO ACIDS FOR 5JS5_A_ASCA202_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1by9 REGULATORY PROTEIN
E2

(Alphapapillomavirus
9) 		PF00511
(PPV_E2_C) 		3 CYH A 307
LYS A 305
HIS A 306
 None
 1.08A 5js5A-1by9A:
undetectable		 5js5A-1by9A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d6m DNA TOPOISOMERASE
III

(Escherichia
coli) 		PF01131
(Topoisom_bac)
PF01751
(Toprim) 		3 CYH A 475
LYS A 477
HIS A 227
 None
 1.28A 5js5A-1d6mA:
0.0		 5js5A-1d6mA:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dut DUTP PYROPHOSPHATASE

(Feline
immunodeficiency
virus) 		PF00692
(dUTPase) 		3 CYH A 106
LYS A 107
HIS A 108
 None
 1.24A 5js5A-1dutA:
undetectable		 5js5A-1dutA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ezf FARNESYL-DIPHOSPHATE
FARNESYLTRANSFERASE

(Homo sapiens) 		PF00494
(SQS_PSY) 		3 CYH A 172
LYS A 170
HIS A 173
 None
 1.26A 5js5A-1ezfA:
2.7		 5js5A-1ezfA:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kbl PYRUVATE PHOSPHATE
DIKINASE

([Clostridium]
symbiosum) 		PF00391
(PEP-utilizers)
PF01326
(PPDK_N)
PF02896
(PEP-utilizers_C) 		3 CYH A 844
LYS A 846
HIS A 845
 None
 1.03A 5js5A-1kblA:
0.5		 5js5A-1kblA:
9.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ku1 ARF
GUANINE-NUCLEOTIDE
EXCHANGE FACTOR 2

(Saccharomyces
cerevisiae) 		PF01369
(Sec7) 		3 CYH A 734
LYS A 737
HIS A 736
 None
 1.12A 5js5A-1ku1A:
undetectable		 5js5A-1ku1A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lur ALDOSE 1-EPIMERASE

(Caenorhabditis
elegans) 		PF01263
(Aldose_epim) 		3 CYH A1277
LYS A1278
HIS A1284
 None
 1.00A 5js5A-1lurA:
undetectable		 5js5A-1lurA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mk7 TALIN

(Gallus gallus) 		PF00373
(FERM_M)
PF02174
(IRS) 		3 CYH B 286
LYS B 284
HIS B 250
 None
 1.20A 5js5A-1mk7B:
1.3		 5js5A-1mk7B:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n21 (+)-BORNYL
DIPHOSPHATE SYNTHASE

(Salvia
officinalis) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		3 CYH A 139
LYS A 138
HIS A 141
 None
 1.15A 5js5A-1n21A:
1.1		 5js5A-1n21A:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qye ENDOPLASMIN

(Canis lupus) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		3 CYH A 138
LYS A 137
HIS A 146
 None
 1.25A 5js5A-1qyeA:
undetectable		 5js5A-1qyeA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s7a LUPUS LA PROTEIN

(Homo sapiens) 		PF05383
(La) 		3 CYH A  18
LYS A  16
HIS A  19
 None
 1.05A 5js5A-1s7aA:
undetectable		 5js5A-1s7aA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sum PHOSPHATE TRANSPORT
SYSTEM PROTEIN PHOU
HOMOLOG 2

(Thermotoga
maritima) 		PF01895
(PhoU) 		3 CYH B  97
LYS B  96
HIS B  98
 None
 1.11A 5js5A-1sumB:
4.2		 5js5A-1sumB:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wia HYPOTHETICAL
UBIQUITIN-LIKE
PROTEIN (RIKEN CDNA
2010008E23)

(Mus musculus) 		PF00240
(ubiquitin) 		3 CYH A 229
LYS A 201
HIS A 230
 None
 1.27A 5js5A-1wiaA:
undetectable		 5js5A-1wiaA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wrb DJVLGB

(Dugesia
japonica) 		PF00270
(DEAD) 		3 CYH A 264
LYS A 263
HIS A 313
 None
 1.08A 5js5A-1wrbA:
undetectable		 5js5A-1wrbA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x4f MATRIN 3

(Mus musculus) 		PF00076
(RRM_1) 		3 CYH A  82
LYS A  85
HIS A  81
 None
 1.14A 5js5A-1x4fA:
undetectable		 5js5A-1x4fA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xfa CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR

(Mus musculus) 		PF00005
(ABC_tran)
PF14396
(CFTR_R) 		3 CYH A 434
LYS A 429
HIS A 432
 None
 1.22A 5js5A-1xfaA:
undetectable		 5js5A-1xfaA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xls RETINOIC ACID
RECEPTOR RXR-ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		3 CYH A 404
LYS A 407
HIS A 406
 None
 1.22A 5js5A-1xlsA:
0.5		 5js5A-1xlsA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yke RNA POLYMERASE II
MEDIATOR COMPLEX
PROTEIN MED7

(Saccharomyces
cerevisiae) 		PF05983
(Med7) 		3 CYH A 196
LYS A 197
HIS A 200
 None
 1.06A 5js5A-1ykeA:
2.6		 5js5A-1ykeA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z5v TUBULIN GAMMA-1
CHAIN

(Homo sapiens) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		3 CYH A 316
LYS A 313
HIS A 315
 None
 1.28A 5js5A-1z5vA:
undetectable		 5js5A-1z5vA:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aff ANTIGEN KI-67

(Homo sapiens) 		PF00498
(FHA) 		3 CYH A  49
LYS A  50
HIS A  61
 None
 0.91A 5js5A-2affA:
undetectable		 5js5A-2affA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cu8 CYSTEINE-RICH
PROTEIN 2

(Homo sapiens) 		PF00412
(LIM) 		3 CYH A  60
LYS A  62
HIS A  61
 ZN  A 401 (-2.3A)
None
None
 1.18A 5js5A-2cu8A:
undetectable		 5js5A-2cu8A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2div TRNA SELENOCYSTEINE
ASSOCIATED PROTEIN

(Homo sapiens) 		PF00076
(RRM_1) 		3 CYH A  68
LYS A  67
HIS A  70
 None
 1.09A 5js5A-2divA:
undetectable		 5js5A-2divA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2elu ZINC FINGER PROTEIN
406

(Homo sapiens) 		PF02892
(zf-BED) 		3 CYH A  12
LYS A  16
HIS A  11
 ZN  A 181 (-2.3A)
None
None
 1.12A 5js5A-2eluA:
undetectable		 5js5A-2eluA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hxr HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CYNR

(Escherichia
coli) 		PF03466
(LysR_substrate) 		3 CYH A 208
LYS A 210
HIS A 206
 None
 1.19A 5js5A-2hxrA:
undetectable		 5js5A-2hxrA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jtn LIM DOMAIN-BINDING
PROTEIN 1,
LIM/HOMEOBOX PROTEIN
LHX3

(Mus musculus) 		PF00412
(LIM) 		3 CYH A  90
LYS A  89
HIS A  94
 ZN  A 184 (-2.3A)
None
None
 1.18A 5js5A-2jtnA:
undetectable		 5js5A-2jtnA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k31 PHOSPHODIESTERASE
5A, CGMP-SPECIFIC

(Mus musculus) 		PF01590
(GAF) 		3 CYH A 159
LYS A 161
HIS A 160
 None
 1.11A 5js5A-2k31A:
undetectable		 5js5A-2k31A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mjw PROTEIN S100-P

(Homo sapiens) 		PF01023
(S_100) 		3 CYH B  85
LYS B  87
HIS B  86
 None
 1.19A 5js5A-2mjwB:
undetectable		 5js5A-2mjwB:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nq9 ENDONUCLEASE 4

(Escherichia
coli) 		PF01261
(AP_endonuc_2) 		3 CYH A  56
LYS A  58
HIS A  60
 None
 1.26A 5js5A-2nq9A:
undetectable		 5js5A-2nq9A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1w ENDOPLASMIN

(Canis lupus) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		3 CYH A 138
LYS A 137
HIS A 146
 None
 1.21A 5js5A-2o1wA:
undetectable		 5js5A-2o1wA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oqb HISTONE-ARGININE
METHYLTRANSFERASE
CARM1

(Rattus
norvegicus) 		PF11531
(CARM1) 		3 CYH A 128
LYS A 126
HIS A 131
 None
 1.19A 5js5A-2oqbA:
undetectable		 5js5A-2oqbA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p82 CYSTEINE PROTEASE
ATG4A

(Homo sapiens) 		PF03416
(Peptidase_C54) 		3 CYH A 124
LYS A 122
HIS A 129
 None
 0.99A 5js5A-2p82A:
undetectable		 5js5A-2p82A:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ptz ENOLASE

(Trypanosoma
brucei) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		3 CYH A 279
LYS A 280
HIS A 283
 None
 0.56A 5js5A-2ptzA:
undetectable		 5js5A-2ptzA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q3x REGULATING SYNAPTIC
MEMBRANE EXOCYTOSIS
PROTEIN 1

(Rattus
norvegicus) 		PF00168
(C2) 		3 CYH A1557
LYS A1556
HIS A1555
 None
SO4  A 201 ( 2.7A)
None
 1.06A 5js5A-2q3xA:
undetectable		 5js5A-2q3xA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qop HTH-TYPE
TRANSCRIPTIONAL
REGULATOR ACRR

(Escherichia
coli) 		PF00440
(TetR_N)
PF08361
(TetR_C_2) 		3 CYH A 117
LYS A 116
HIS A 115
 None
 0.89A 5js5A-2qopA:
undetectable		 5js5A-2qopA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r5j MAJOR CAPSID PROTEIN
L1

(Alphapapillomavirus
9) 		PF00500
(Late_protein_L1) 		3 CYH A 229
LYS A 230
HIS A 168
 None
 1.13A 5js5A-2r5jA:
undetectable		 5js5A-2r5jA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uwq APOPTOSIS-STIMULATIN
G OF P53 PROTEIN 2

(Homo sapiens) 		no annotation 3 CYH A  35
LYS A  36
HIS A  82
 None
 1.28A 5js5A-2uwqA:
undetectable		 5js5A-2uwqA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uxo HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR

(Pseudomonas
putida) 		PF00440
(TetR_N)
PF08361
(TetR_C_2) 		3 CYH A 117
LYS A 116
HIS A 115
 None
 0.94A 5js5A-2uxoA:
3.6		 5js5A-2uxoA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x0s PYRUVATE PHOSPHATE
DIKINASE

(Trypanosoma
brucei) 		PF00391
(PEP-utilizers)
PF01326
(PPDK_N)
PF02896
(PEP-utilizers_C) 		3 CYH A 868
LYS A 870
HIS A 869
 None
 1.21A 5js5A-2x0sA:
undetectable		 5js5A-2x0sA:
8.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y35 LD22664P

(Drosophila
melanogaster) 		PF03159
(XRN_N) 		3 CYH A1106
LYS A1107
HIS A1086
 None
 1.26A 5js5A-2y35A:
undetectable		 5js5A-2y35A:
7.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ys8 RAB-RELATED
GTP-BINDING PROTEIN
RABJ

(Homo sapiens) 		PF00226
(DnaJ) 		3 CYH A  60
LYS A  59
HIS A  56
 None
 1.07A 5js5A-2ys8A:
undetectable		 5js5A-2ys8A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bil PROBABLE LACI-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Corynebacterium
glutamicum) 		PF13407
(Peripla_BP_4) 		3 CYH A 259
LYS A 261
HIS A 260
 None
 1.21A 5js5A-3bilA:
undetectable		 5js5A-3bilA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3epm THIAMINE
BIOSYNTHESIS PROTEIN
THIC

(Caulobacter
vibrioides) 		PF01964
(ThiC_Rad_SAM)
PF13667
(ThiC-associated) 		3 CYH A 343
LYS A 348
HIS A 346
 None
 0.98A 5js5A-3epmA:
undetectable		 5js5A-3epmA:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g5b NETRIN RECEPTOR
UNC5B

(Rattus
norvegicus) 		PF00531
(Death)
PF00791
(ZU5)
PF17217
(UPA) 		3 CYH A 808
LYS A 809
HIS A 759
 None
 1.24A 5js5A-3g5bA:
undetectable		 5js5A-3g5bA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g9w TALIN-2

(Mus musculus) 		PF00373
(FERM_M)
PF02174
(IRS) 		3 CYH A 289
LYS A 287
HIS A 252
 None
 1.14A 5js5A-3g9wA:
undetectable		 5js5A-3g9wA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ggr CELL CYCLE
CHECKPOINT CONTROL
PROTEIN RAD9A

(Homo sapiens) 		PF04139
(Rad9) 		3 CYH A  97
LYS A  96
HIS A 113
 None
 1.00A 5js5A-3ggrA:
undetectable		 5js5A-3ggrA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhd FATTY ACID SYNTHASE

(Homo sapiens) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		3 CYH A 212
LYS A 213
HIS A 358
 None
 1.17A 5js5A-3hhdA:
undetectable		 5js5A-3hhdA:
9.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ism CG8862

(Drosophila
melanogaster) 		PF01223
(Endonuclease_NS) 		3 CYH A 169
LYS A 167
HIS A 168
 None
 1.26A 5js5A-3ismA:
undetectable		 5js5A-3ismA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iv7 ALCOHOL
DEHYDROGENASE IV

(Corynebacterium
glutamicum) 		PF00465
(Fe-ADH) 		3 CYH A 244
LYS A 242
HIS A 245
 None
 0.97A 5js5A-3iv7A:
2.3		 5js5A-3iv7A:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ivf TALIN-1

(Mus musculus) 		PF00373
(FERM_M)
PF02174
(IRS)
PF09379
(FERM_N)
PF16511
(FERM_f0) 		3 CYH A 286
LYS A 284
HIS A 250
 None
 1.16A 5js5A-3ivfA:
undetectable		 5js5A-3ivfA:
14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jzd IRON-CONTAINING
ALCOHOL
DEHYDROGENASE

(Cupriavidus
pinatubonensis) 		PF00465
(Fe-ADH) 		3 CYH A 245
LYS A 243
HIS A 246
 None
 1.01A 5js5A-3jzdA:
2.5		 5js5A-3jzdA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kyl TELOMERASE REVERSE
TRANSCRIPTASE

(Tribolium
castaneum) 		PF00078
(RVT_1)
PF12009
(Telomerase_RBD) 		3 CYH A  37
LYS A  38
HIS A  40
 None
 1.04A 5js5A-3kylA:
undetectable		 5js5A-3kylA:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kyl TELOMERASE REVERSE
TRANSCRIPTASE

(Tribolium
castaneum) 		PF00078
(RVT_1)
PF12009
(Telomerase_RBD) 		3 CYH A  37
LYS A  39
HIS A  40
 None
 0.98A 5js5A-3kylA:
undetectable		 5js5A-3kylA:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lhq ACRAB OPERON
REPRESSOR (TETR/ACRR
FAMILY)

(Salmonella
enterica) 		PF00440
(TetR_N)
PF08361
(TetR_C_2) 		3 CYH A 117
LYS A 116
HIS A 115
 None
 0.89A 5js5A-3lhqA:
2.2		 5js5A-3lhqA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nnk UREIDOGLYCINE-GLYOXY
LATE
AMINOTRANSFERASE

(Klebsiella
pneumoniae) 		PF00266
(Aminotran_5) 		3 CYH A 375
LYS A 373
HIS A 298
 None
 1.09A 5js5A-3nnkA:
undetectable		 5js5A-3nnkA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ofl L1

(Alphapapillomavirus
7) 		PF00500
(Late_protein_L1) 		3 CYH A 229
LYS A 230
HIS A 168
 None
 1.12A 5js5A-3oflA:
undetectable		 5js5A-3oflA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pds FUSION PROTEIN
BETA-2 ADRENERGIC
RECEPTOR/LYSOZYME

(Homo sapiens;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		3 CYH A 265
LYS A 263
HIS A 269
 None
 1.12A 5js5A-3pdsA:
4.9		 5js5A-3pdsA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pmq DECAHEME CYTOCHROME
C MTRF

(Shewanella
oneidensis) 		no annotation 3 CYH A 115
LYS A 123
HIS A 122
 None
 1.12A 5js5A-3pmqA:
undetectable		 5js5A-3pmqA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qc3 D-RIBULOSE-5-PHOSPHA
TE-3-EPIMERASE

(Homo sapiens) 		PF00834
(Ribul_P_3_epim) 		3 CYH A 186
LYS A 185
HIS A 184
 None
 1.04A 5js5A-3qc3A:
undetectable		 5js5A-3qc3A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a01 PROTON
PYROPHOSPHATASE

(Vigna radiata) 		PF03030
(H_PPase) 		3 CYH A 715
LYS A 717
HIS A 716
 None
 1.23A 5js5A-4a01A:
1.4		 5js5A-4a01A:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c1s GLYCOSIDE HYDROLASE
FAMILY 76
MANNOSIDASE

(Bacteroides
thetaiotaomicron) 		PF03663
(Glyco_hydro_76) 		3 CYH A 418
LYS A 420
HIS A 419
 None
 1.25A 5js5A-4c1sA:
undetectable		 5js5A-4c1sA:
18.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4cx9 CYTOCHROME C, CLASS
II

(Shewanella
frigidimarina) 		PF01322
(Cytochrom_C_2) 		3 CYH A 118
LYS A 119
HIS A 122
 HEC  A1129 (-1.9A)
None
NO  A1130 (-4.8A)
 0.31A 5js5A-4cx9A:
19.8		 5js5A-4cx9A:
42.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dix PLECTIN-RELATED
PROTEIN

(Arabidopsis
thaliana) 		PF16709
(SCAB-IgPH) 		3 CYH A 414
LYS A 415
HIS A 402
 None
 1.06A 5js5A-4dixA:
undetectable		 5js5A-4dixA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ea1 DEHYDROSQUALENE
SYNTHASE

(Staphylococcus
aureus) 		PF00494
(SQS_PSY) 		3 CYH A  11
LYS A   9
HIS A  12
 None
 1.13A 5js5A-4ea1A:
2.9		 5js5A-4ea1A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fgw GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
[NAD(+)] 1

(Saccharomyces
cerevisiae) 		PF01210
(NAD_Gly3P_dh_N)
PF07479
(NAD_Gly3P_dh_C) 		3 CYH A 344
LYS A 345
HIS A 348
 None
 0.77A 5js5A-4fgwA:
undetectable		 5js5A-4fgwA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jrl PUTATIVE GLYCOSIDE
HYDROLASE

(Bacteroides
ovatus) 		PF13201
(PCMD) 		3 CYH A 373
LYS A 374
HIS A 242
 None
 1.14A 5js5A-4jrlA:
undetectable		 5js5A-4jrlA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4le5 S-ADENOSYLMETHIONINE
SYNTHETASE

(Campylobacter
jejuni) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		3 CYH A  17
LYS A  16
HIS A  13
 None
 1.26A 5js5A-4le5A:
undetectable		 5js5A-4le5A:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mz0 CURL

(Moorea
producens) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		3 CYH A 260
LYS A 261
HIS A 411
 None
 1.23A 5js5A-4mz0A:
undetectable		 5js5A-4mz0A:
8.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ohs FAR-RED FLUORESCENT
PROTEIN AQ143

(Actinia equina) 		PF01353
(GFP) 		3 CYH A 164
LYS A 163
HIS A 169
 None
 1.24A 5js5A-4ohsA:
undetectable		 5js5A-4ohsA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ppm AMINOTRANSFERASE

(Serratia sp.
FS14) 		PF00202
(Aminotran_3) 		3 CYH A 804
LYS A 802
HIS A 807
 None
 0.99A 5js5A-4ppmA:
undetectable		 5js5A-4ppmA:
9.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rlv ANKYRIN-1, ANKYRIN-2

(Homo sapiens;
Mus musculus) 		PF00023
(Ank)
PF12796
(Ank_2)
PF13637
(Ank_4)
PF13857
(Ank_5) 		3 CYH A2406
LYS A2407
HIS A2443
 None
SO4  A2908 (-2.5A)
None
 1.11A 5js5A-4rlvA:
undetectable		 5js5A-4rlvA:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4upk PHOSPHONATE
MONOESTER HYDROLASE

(Ruegeria
pomeroyi) 		PF00884
(Sulfatase) 		3 CYH A 350
LYS A 351
HIS A 354
 None
 1.17A 5js5A-4upkA:
undetectable		 5js5A-4upkA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		3 CYH A2547
LYS A2548
HIS A2698
 None
 1.13A 5js5A-4z37A:
undetectable		 5js5A-4z37A:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zdl O-PHOSPHOSERYL-TRNA(
SEC) SELENIUM
TRANSFERASE

(Homo sapiens) 		PF05889
(SepSecS) 		3 CYH A 262
LYS A 261
HIS A 264
 None
 1.00A 5js5A-4zdlA:
undetectable		 5js5A-4zdlA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zwo ORGANOPHOSPHATE
ANHYDROLASE/PROLIDAS
E

(Alteromonas sp.) 		PF00557
(Peptidase_M24) 		3 CYH A 368
LYS A 365
HIS A 296
 None
 1.20A 5js5A-4zwoA:
undetectable		 5js5A-4zwoA:
15.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c3o THYMINE DIOXYGENASE

(Neurospora
crassa) 		PF03171
(2OG-FeII_Oxy)
PF14226
(DIOX_N) 		3 CYH A 156
LYS A 157
HIS A 160
 None
 0.43A 5js5A-5c3oA:
undetectable		 5js5A-5c3oA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dpd PROTEIN LYSINE
METHYLTRANSFERASE 1

(Rickettsia
prowazekii) 		PF10119
(MethyTransf_Reg)
PF13847
(Methyltransf_31) 		3 CYH A 164
LYS A 162
HIS A 272
 None
 0.95A 5js5A-5dpdA:
undetectable		 5js5A-5dpdA:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dst PROTEIN ARGININE
N-METHYLTRANSFERASE
8

(Homo sapiens) 		PF06325
(PrmA) 		3 CYH A 318
LYS A 320
HIS A 319
 None
 1.07A 5js5A-5dstA:
undetectable		 5js5A-5dstA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e7o DMSO REDUCTASE
FAMILY TYPE II
ENZYME, IRON-SULFUR
SUBUNIT

(Azospira oryzae) 		PF13247
(Fer4_11) 		3 CYH B 170
LYS B 169
HIS B 166
 F3S  B 402 (-2.8A)
None
None
 1.28A 5js5A-5e7oB:
undetectable		 5js5A-5e7oB:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fz5 TRANSCRIPTION
INITIATION FACTOR
IIB

(Saccharomyces
cerevisiae) 		PF00382
(TFIIB)
PF08271
(TF_Zn_Ribbon) 		3 CYH M 157
LYS M 155
HIS M 158
 None
 1.03A 5js5A-5fz5M:
undetectable		 5js5A-5fz5M:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hou CELLULAR TUMOR
ANTIGEN
P53,CREB-BINDING
PROTEIN FUSION
PROTEIN

(Homo sapiens;
Mus musculus) 		PF02135
(zf-TAZ)
PF08563
(P53_TAD) 		3 CYH A3366
LYS A3365
HIS A3364
 ZN  A5001 ( 2.2A)
None
None
 0.97A 5js5A-5houA:
undetectable		 5js5A-5houA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iig VACUOLAR TRANSPORTER
CHAPERONE 4

(Saccharomyces
cerevisiae) 		PF03105
(SPX)
PF09359
(VTC) 		3 CYH A  63
LYS A  64
HIS A  67
 None
 0.72A 5js5A-5iigA:
undetectable		 5js5A-5iigA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lw7 ABC TRANSPORTER
ATP-BINDING PROTEIN

(Pyrococcus
abyssi) 		PF00005
(ABC_tran)
PF00037
(Fer4)
PF04068
(RLI) 		3 CYH B  61
LYS B  64
HIS B  63
 SF4  B 601 (-2.7A)
None
None
 1.22A 5js5A-5lw7B:
undetectable		 5js5A-5lw7B:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lw7 ABC TRANSPORTER
ATP-BINDING PROTEIN

(Pyrococcus
abyssi) 		PF00005
(ABC_tran)
PF00037
(Fer4)
PF04068
(RLI) 		3 CYH B  65
LYS B  64
HIS B  63
 SF4  B 602 (-2.8A)
None
None
 1.17A 5js5A-5lw7B:
undetectable		 5js5A-5lw7B:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mkw DNA ANNEALING
HELICASE AND
ENDONUCLEASE ZRANB3

(Homo sapiens) 		PF01844
(HNH) 		3 CYH A  99
LYS A 101
HIS A 100
 ZN  A 201 (-2.3A)
None
None
 1.10A 5js5A-5mkwA:
undetectable		 5js5A-5mkwA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o9w THEBAINE
6-O-DEMETHYLASE

(Papaver
somniferum) 		no annotation 3 CYH A  82
LYS A  83
HIS A 291
 None
 1.21A 5js5A-5o9wA:
undetectable		 5js5A-5o9wA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5suj UNCHARACTERIZED
PROTEIN

(Legionella
pneumophila) 		no annotation 3 CYH A  73
LYS A  71
HIS A  74
 None
 1.11A 5js5A-5sujA:
undetectable		 5js5A-5sujA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sva MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 7

(Saccharomyces
cerevisiae) 		PF05983
(Med7) 		3 CYH U 196
LYS U 197
HIS U 200
 None
 1.05A 5js5A-5svaU:
3.2		 5js5A-5svaU:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v1m U6 SNRNA
PHOSPHODIESTERASE

(Homo sapiens) 		PF09749
(HVSL) 		3 CYH A 253
LYS A 254
HIS A  84
 None
GOL  A 303 (-3.5A)
GOL  A 303 (-3.4A)
 1.12A 5js5A-5v1mA:
undetectable		 5js5A-5v1mA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y4d ANKYRIN-1,ANKYRIN-2,
ANKYRIN-2

(Homo sapiens;
Mus musculus) 		PF00023
(Ank)
PF12796
(Ank_2)
PF13637
(Ank_4) 		3 CYH A2406
LYS A2407
HIS A2443
 None
 1.21A 5js5A-5y4dA:
undetectable		 5js5A-5y4dA:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y9c MAJOR CAPSID PROTEIN
L1

(Alphapapillomavirus
9) 		no annotation 3 CYH A 229
LYS A 230
HIS A 169
 None
 1.16A 5js5A-5y9cA:
undetectable		 5js5A-5y9cA:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z95 -

(-) 		no annotation 3 CYH A  89
LYS A  88
HIS A 113
 None
 0.99A 5js5A-5z95A:
undetectable		 5js5A-5z95A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6aom ENDOPLASMIN

(Canis lupus) 		no annotation 3 CYH A 138
LYS A 137
HIS A 146
 None
P33  A 402 (-2.6A)
P33  A 402 ( 4.0A)
 1.18A 5js5A-6aomA:
undetectable		 5js5A-6aomA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bsp MAJOR CAPSID PROTEIN
L1

(Alphapapillomavirus
9) 		no annotation 3 CYH C 229
LYS C 230
HIS C 168
 None
 1.04A 5js5A-6bspC:
undetectable		 5js5A-6bspC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9m N-ALPHA-ACETYLTRANSF
ERASE 15, NATA
AUXILIARY SUBUNIT

(Homo sapiens) 		no annotation 3 CYH A 828
LYS A 830
HIS A 829
 None
 1.27A 5js5A-6c9mA:
undetectable		 5js5A-6c9mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6q EXOSOME COMPLEX
COMPONENT RRP42

(Homo sapiens) 		no annotation 3 CYH E 204
LYS E 205
HIS E 210
 None
 1.02A 5js5A-6d6qE:
undetectable		 5js5A-6d6qE:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6q EXOSOME RNA HELICASE
MTR4

(Homo sapiens) 		no annotation 3 CYH M 911
LYS M 963
HIS M 965
 None
 0.95A 5js5A-6d6qM:
undetectable		 5js5A-6d6qM:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6r EXOSOME COMPLEX
COMPONENT CSL4

(Homo sapiens) 		no annotation 3 CYH I  73
LYS I  74
HIS I  86
 None
 0.66A 5js5A-6d6rI:
undetectable		 5js5A-6d6rI:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ez8 HUNTINGTIN

(Homo sapiens) 		no annotation 3 CYH A1591
LYS A1593
HIS A1592
 None
 0.97A 5js5A-6ez8A:
undetectable		 5js5A-6ez8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f42 DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC1

(Saccharomyces
cerevisiae) 		no annotation 3 CYH A 738
LYS A 737
HIS A 736
 None
 1.22A 5js5A-6f42A:
undetectable		 5js5A-6f42A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6h25 -

(-) 		no annotation 3 CYH A 115
LYS A 114
HIS A 188
 None
 0.88A 5js5A-6h25A:
undetectable		 5js5A-6h25A:
undetectable