SIMILAR PATTERNS OF AMINO ACIDS FOR 5JRA_A_ASCA202_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gqa CYTOCHROME C'

(Rhodobacter
sphaeroides) 		PF01322
(Cytochrom_C_2) 		4 GLY A 116
CYH A 119
LYS A 120
HIS A 123
 None
HEC  A 131 (-1.8A)
None
HEC  A 131 (-3.1A)
 0.20A 5jraA-1gqaA:
17.5		 5jraA-1gqaA:
39.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gqa CYTOCHROME C'

(Rhodobacter
sphaeroides) 		PF01322
(Cytochrom_C_2) 		4 GLY A 117
CYH A 119
LYS A 120
HIS A 123
 None
HEC  A 131 (-1.8A)
None
HEC  A 131 (-3.1A)
 1.01A 5jraA-1gqaA:
17.5		 5jraA-1gqaA:
39.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mqv CYTOCHROME C'

(Rhodopseudomonas
palustris) 		PF01322
(Cytochrom_C_2) 		4 GLY A 111
CYH A 113
LYS A 114
HIS A 117
 None
HEM  A 150 (-1.9A)
None
HEM  A 150 (-3.3A)
 0.86A 5jraA-1mqvA:
14.7		 5jraA-1mqvA:
35.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nbb CYTOCHROME C'

(Rhodobacter
capsulatus) 		PF01322
(Cytochrom_C_2) 		4 GLY A 115
CYH A 118
LYS A 119
HIS A 122
 None
HEM  A 130 (-1.7A)
None
HEM  A 130 (-3.2A)
 0.28A 5jraA-1nbbA:
17.5		 5jraA-1nbbA:
31.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nbb CYTOCHROME C'

(Rhodobacter
capsulatus) 		PF01322
(Cytochrom_C_2) 		4 GLY A 116
CYH A 118
LYS A 119
HIS A 122
 None
HEM  A 130 (-1.7A)
None
HEM  A 130 (-3.2A)
 1.05A 5jraA-1nbbA:
17.5		 5jraA-1nbbA:
31.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ccy CYTOCHROME C

(Phaeospirillum
molischianum) 		PF01322
(Cytochrom_C_2) 		4 GLY A 115
CYH A 118
LYS A 119
HIS A 122
 None
HEM  A 129 (-1.7A)
None
HEM  A 129 (-3.2A)
 0.90A 5jraA-2ccyA:
16.2		 5jraA-2ccyA:
34.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h65 PYRIMIDINE PRECURSOR
BIOSYNTHESIS ENZYME
THI5

(Saccharomyces
cerevisiae) 		PF09084
(NMT1) 		4 GLY A 331
CYH A 327
LYS A 326
HIS A 323
 None
 1.40A 5jraA-4h65A:
undetectable		 5jraA-4h65A:
17.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5gyr CYTOCHROME C'

(Allochromatium
vinosum) 		PF01322
(Cytochrom_C_2) 		4 GLY A 118
CYH A 121
LYS A 122
HIS A 125
 None
HEM  A 201 (-2.2A)
None
HEM  A 201 (-3.4A)
 0.55A 5jraA-5gyrA:
5.2		 5jraA-5gyrA:
32.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jt4 CYTOCHROME C'

(Achromobacter
xylosoxidans) 		PF01322
(Cytochrom_C_2) 		4 GLY A 113
CYH A 116
LYS A 117
HIS A 120
 ASC  A 202 (-3.9A)
HEC  A 201 (-1.9A)
None
HEC  A 201 (-3.2A)
 0.12A 5jraA-5jt4A:
24.6		 5jraA-5jt4A:
99.20