SIMILAR PATTERNS OF AMINO ACIDS FOR 5JQB_B_IBPB706

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a0p SITE-SPECIFIC
RECOMBINASE XERD

(Escherichia
coli) 		PF00589
(Phage_integrase)
PF02899
(Phage_int_SAM_1) 		5 ALA A 137
LEU A 181
LEU A 193
TYR A 192
LEU A 162
 None
 1.47A 5jqbA-1a0pA:
0.0
5jqbB-1a0pA:
0.2		 5jqbA-1a0pA:
23.88
5jqbB-1a0pA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1au8 CATHEPSIN G

(Homo sapiens) 		PF00089
(Trypsin) 		5 ARG A 239
LEU A 123
LEU A 235
LEU A 105
LEU A  53
 None
 1.47A 5jqbA-1au8A:
0.0
5jqbB-1au8A:
0.0		 5jqbA-1au8A:
19.51
5jqbB-1au8A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1awc PROTEIN (GA BINDING
PROTEIN ALPHA)

(Mus musculus) 		PF00178
(Ets) 		5 ALA A 357
LEU A 322
LEU A 350
TYR A 371
LEU A 326
 None
 1.35A 5jqbA-1awcA:
0.0
5jqbB-1awcA:
0.7		 5jqbA-1awcA:
17.16
5jqbB-1awcA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bix AP ENDONUCLEASE 1

(Homo sapiens) 		PF03372
(Exo_endo_phos) 		5 ALA A 170
LEU A 205
LEU A 199
LEU A 243
LEU A 249
 None
 1.30A 5jqbA-1bixA:
0.0
5jqbB-1bixA:
0.0		 5jqbA-1bixA:
21.81
5jqbB-1bixA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bou 4,5-DIOXYGENASE
ALPHA CHAIN

(Sphingomonas
paucimobilis) 		PF07746
(LigA) 		5 ARG A  77
LEU A  92
LEU A  95
LEU A  66
LEU A  37
 None
 1.41A 5jqbA-1bouA:
undetectable
5jqbB-1bouA:
undetectable		 5jqbA-1bouA:
18.18
5jqbB-1bouA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c3r HDLP (HISTONE
DEACETYLASE-LIKE
PROTEIN)

(Aquifex
aeolicus) 		PF00850
(Hist_deacetyl) 		5 ALA A  37
LEU A 322
LEU A 351
LEU A  30
LEU A 330
 None
 1.35A 5jqbA-1c3rA:
0.0
5jqbB-1c3rA:
undetectable		 5jqbA-1c3rA:
21.52
5jqbB-1c3rA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cp2 NITROGENASE IRON
PROTEIN

(Clostridium
pasteurianum) 		PF00142
(Fer4_NifH) 		5 ALA A 154
LEU A 192
LEU A 193
LEU A 261
LEU A 265
 None
 1.38A 5jqbA-1cp2A:
0.0
5jqbB-1cp2A:
undetectable		 5jqbA-1cp2A:
24.20
5jqbB-1cp2A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dl7 PROTEIN (ANTIBODY
M3C65 (HEAVY CHAIN))

(Mus musculus) 		PF07686
(V-set) 		5 ALA H  91
LEU H  18
LEU H  85
LEU H  48
LEU H  80
 None
 1.10A 5jqbA-1dl7H:
0.0
5jqbB-1dl7H:
0.0		 5jqbA-1dl7H:
15.68
5jqbB-1dl7H:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dml DNA POLYMERASE
PROCESSIVITY FACTOR

(Human
alphaherpesvirus
1) 		PF02282
(Herpes_UL42) 		5 ALA A 311
LEU A 185
LEU A 189
LEU A 299
LEU A 288
 None
 1.18A 5jqbA-1dmlA:
0.0
5jqbB-1dmlA:
0.0		 5jqbA-1dmlA:
22.58
5jqbB-1dmlA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ee8 MUTM (FPG) PROTEIN

(Thermus
thermophilus) 		PF01149
(Fapy_DNA_glyco)
PF06827
(zf-FPG_IleRS)
PF06831
(H2TH) 		4 ALA A 171
LEU A 146
LEU A 150
LEU A 182
 None
 0.68A 5jqbA-1ee8A:
0.0
5jqbB-1ee8A:
0.0		 5jqbA-1ee8A:
23.43
5jqbB-1ee8A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eh6 O6-ALKYLGUANINE-DNA
ALKYLTRANSFERASE

(Homo sapiens) 		PF01035
(DNA_binding_1)
PF02870
(Methyltransf_1N) 		5 ALA A  64
LEU A  28
LEU A 142
LEU A  12
LEU A  21
 None
 1.38A 5jqbA-1eh6A:
undetectable
5jqbB-1eh6A:
0.0		 5jqbA-1eh6A:
19.23
5jqbB-1eh6A:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g0v PROTEINASE A

(Saccharomyces
cerevisiae) 		PF00026
(Asp) 		5 LEU A   6
LEU A 155
LEU A 123
TYR A 313
LEU A  31
 None
 1.21A 5jqbA-1g0vA:
undetectable
5jqbB-1g0vA:
0.0		 5jqbA-1g0vA:
23.94
5jqbB-1g0vA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g55 DNA CYTOSINE
METHYLTRANSFERASE
DNMT2

(Homo sapiens) 		PF00145
(DNA_methylase) 		5 ALA A 167
LEU A 106
LEU A 118
MET A  75
LEU A 133
 None
 1.26A 5jqbA-1g55A:
undetectable
5jqbB-1g55A:
undetectable		 5jqbA-1g55A:
22.72
5jqbB-1g55A:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hbx ETS-DOMAIN PROTEIN
ELK-4

(Homo sapiens) 		PF00178
(Ets) 		5 ALA G  42
LEU G   7
LEU G  35
TYR G  56
LEU G  11
 None
 1.28A 5jqbA-1hbxG:
undetectable
5jqbB-1hbxG:
undetectable		 5jqbA-1hbxG:
17.95
5jqbB-1hbxG:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hxn HEMOPEXIN

(Oryctolagus
cuniculus) 		PF00045
(Hemopexin) 		5 ALA A 282
LEU A 317
LEU A 329
LEU A 344
LEU A 321
 CL  A   3 ( 4.0A)
None
None
None
None
 1.23A 5jqbA-1hxnA:
undetectable
5jqbB-1hxnA:
undetectable		 5jqbA-1hxnA:
20.43
5jqbB-1hxnA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hxn HEMOPEXIN

(Oryctolagus
cuniculus) 		PF00045
(Hemopexin) 		5 ALA A 335
LEU A 317
LEU A 329
LEU A 355
LEU A 321
 CL  A   3 ( 4.7A)
None
None
None
None
 1.45A 5jqbA-1hxnA:
undetectable
5jqbB-1hxnA:
undetectable		 5jqbA-1hxnA:
20.43
5jqbB-1hxnA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i7q TRPG

(Serratia
marcescens) 		PF00117
(GATase) 		5 ARG B  74
ALA B  37
LEU B  75
LEU B   7
LEU B  53
 None
 1.29A 5jqbA-1i7qB:
1.3
5jqbB-1i7qB:
undetectable		 5jqbA-1i7qB:
20.61
5jqbB-1i7qB:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iuh 2'-5' RNA LIGASE

(Thermus
thermophilus) 		PF02834
(LigT_PEase) 		4 ALA A  72
LEU A 101
LEU A  42
LEU A 179
 None
 0.72A 5jqbA-1iuhA:
undetectable
5jqbB-1iuhA:
undetectable		 5jqbA-1iuhA:
20.97
5jqbB-1iuhA:
25.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jqo PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Zea mays) 		PF00311
(PEPcase) 		5 ALA A 164
LEU A 267
LEU A 147
LEU A 282
LEU A 276
 None
 1.39A 5jqbA-1jqoA:
undetectable
5jqbB-1jqoA:
undetectable		 5jqbA-1jqoA:
15.31
5jqbB-1jqoA:
9.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE

(Lactococcus
lactis) 		PF02129
(Peptidase_S15)
PF08530
(PepX_C)
PF09168
(PepX_N) 		5 ALA A  78
LEU A  37
LEU A  69
LEU A  51
LEU A  41
 None
 1.23A 5jqbA-1lnsA:
undetectable
5jqbB-1lnsA:
undetectable		 5jqbA-1lnsA:
17.80
5jqbB-1lnsA:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lpe APOLIPOPROTEIN E3

(Homo sapiens) 		PF01442
(Apolipoprotein) 		5 ARG A 114
LEU A 141
LEU A 137
LEU A  60
LEU A  37
 None
 1.14A 5jqbA-1lpeA:
undetectable
5jqbB-1lpeA:
0.8		 5jqbA-1lpeA:
18.79
5jqbB-1lpeA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mbx ATP-DEPENDENT CLP
PROTEASE ATP-BINDING
SUBUNIT CLP A

(Escherichia
coli) 		PF02861
(Clp_N) 		5 ALA A  43
LEU A  31
LEU A 124
LEU A  51
LEU A  35
 None
 1.43A 5jqbA-1mbxA:
undetectable
5jqbB-1mbxA:
undetectable		 5jqbA-1mbxA:
17.34
5jqbB-1mbxA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mbx ATP-DEPENDENT CLP
PROTEASE ATP-BINDING
SUBUNIT CLP A

(Escherichia
coli) 		PF02861
(Clp_N) 		5 ALA A  91
LEU A  30
LEU A  34
LEU A   2
LEU A  10
 None
 1.08A 5jqbA-1mbxA:
undetectable
5jqbB-1mbxA:
undetectable		 5jqbA-1mbxA:
17.34
5jqbB-1mbxA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1miv TRNA CCA-ADDING
ENZYME

(Geobacillus
stearothermophilus) 		PF01743
(PolyA_pol)
PF12627
(PolyA_pol_RNAbd)
PF13735
(tRNA_NucTran2_2) 		5 ARG A 163
ALA A 161
LEU A 202
LEU A 220
LEU A 215
 None
 1.29A 5jqbA-1mivA:
undetectable
5jqbB-1mivA:
undetectable		 5jqbA-1mivA:
21.03
5jqbB-1mivA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nox NADH OXIDASE

(Thermus
thermophilus) 		PF00881
(Nitroreductase) 		5 ALA A  40
LEU A 140
LEU A  85
LEU A 147
LEU A 144
 None
 1.40A 5jqbA-1noxA:
undetectable
5jqbB-1noxA:
undetectable		 5jqbA-1noxA:
21.36
5jqbB-1noxA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ojl TRANSCRIPTIONAL
REGULATORY PROTEIN
ZRAR

(Salmonella
enterica) 		PF00158
(Sigma54_activat)
PF02954
(HTH_8) 		5 ARG A 228
ALA A 232
LEU A 210
LEU A 196
LEU A 277
 None
 1.24A 5jqbA-1ojlA:
undetectable
5jqbB-1ojlA:
undetectable		 5jqbA-1ojlA:
23.38
5jqbB-1ojlA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ozn RETICULON 4 RECEPTOR

(Homo sapiens) 		PF13855
(LRR_8) 		5 ALA A 100
LEU A 107
LEU A 129
LEU A  88
LEU A  86
 None
 1.16A 5jqbA-1oznA:
undetectable
5jqbB-1oznA:
undetectable		 5jqbA-1oznA:
21.58
5jqbB-1oznA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ozn RETICULON 4 RECEPTOR

(Homo sapiens) 		PF13855
(LRR_8) 		5 ALA A 197
LEU A 204
LEU A 225
LEU A 185
LEU A 183
 None
 1.29A 5jqbA-1oznA:
undetectable
5jqbB-1oznA:
undetectable		 5jqbA-1oznA:
21.58
5jqbB-1oznA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ozn RETICULON 4 RECEPTOR

(Homo sapiens) 		PF13855
(LRR_8) 		5 ALA A 221
LEU A 228
LEU A 249
LEU A 209
LEU A 207
 None
 1.25A 5jqbA-1oznA:
undetectable
5jqbB-1oznA:
undetectable		 5jqbA-1oznA:
21.58
5jqbB-1oznA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ozn RETICULON 4 RECEPTOR

(Homo sapiens) 		PF13855
(LRR_8) 		5 ALA A 221
LEU A 231
LEU A 249
LEU A 241
LEU A 233
 None
 1.48A 5jqbA-1oznA:
undetectable
5jqbB-1oznA:
undetectable		 5jqbA-1oznA:
21.58
5jqbB-1oznA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p4i ANTIBODY VARIABLE
HEAVY CHAIN

(Mus musculus) 		PF07686
(V-set) 		5 ALA H 102
LEU H  19
LEU H  96
LEU H  55
LEU H  91
 None
 1.23A 5jqbA-1p4iH:
undetectable
5jqbB-1p4iH:
undetectable		 5jqbA-1p4iH:
14.55
5jqbB-1p4iH:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q3s THERMOSOME ALPHA
SUBUNIT

(Thermococcus
sp. JCM 11816) 		PF00118
(Cpn60_TCP1) 		5 ALA A 504
LEU A 139
LEU A 408
LEU A 444
LEU A 418
 None
 1.36A 5jqbA-1q3sA:
undetectable
5jqbB-1q3sA:
undetectable		 5jqbA-1q3sA:
19.29
5jqbB-1q3sA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Escherichia
coli) 		PF00311
(PEPcase) 		5 ARG A 785
LEU A  56
LEU A  60
LEU A 778
TYR A 782
 None
 1.30A 5jqbA-1qb4A:
undetectable
5jqbB-1qb4A:
undetectable		 5jqbA-1qb4A:
16.87
5jqbB-1qb4A:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qd1 FORMIMINOTRANSFERASE
-CYCLODEAMINASE

(Sus scrofa) 		PF02971
(FTCD)
PF07837
(FTCD_N) 		5 ALA A 281
LEU A 183
LEU A 238
LEU A 309
LEU A 269
 None
 1.34A 5jqbA-1qd1A:
undetectable
5jqbB-1qd1A:
undetectable		 5jqbA-1qd1A:
22.66
5jqbB-1qd1A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qnt METHYLATED-DNA--PROT
EIN-CYSTEINE
METHYLTRANSFERASE

(Homo sapiens) 		PF01035
(DNA_binding_1)
PF02870
(Methyltransf_1N) 		5 ALA A  64
LEU A  28
LEU A 142
LEU A  12
LEU A  21
 None
 1.37A 5jqbA-1qntA:
undetectable
5jqbB-1qntA:
undetectable		 5jqbA-1qntA:
18.71
5jqbB-1qntA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qpo QUINOLINATE ACID
PHOSPHORIBOSYL
TRANSFERASE

(Mycobacterium
tuberculosis) 		PF01729
(QRPTase_C)
PF02749
(QRPTase_N) 		5 LEU A 283
LEU A  45
LEU A  67
TYR A  72
LEU A 100
 None
 1.47A 5jqbA-1qpoA:
undetectable
5jqbB-1qpoA:
0.0		 5jqbA-1qpoA:
22.00
5jqbB-1qpoA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6b CLPA PROTEIN

(Escherichia
coli) 		PF00004
(AAA)
PF02861
(Clp_N)
PF07724
(AAA_2)
PF10431
(ClpB_D2-small) 		5 ALA X  91
LEU X  30
LEU X  34
LEU X   2
LEU X  10
 None
 1.18A 5jqbA-1r6bX:
undetectable
5jqbB-1r6bX:
undetectable		 5jqbA-1r6bX:
19.13
5jqbB-1r6bX:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ser PROTEIN (SERYL-TRNA
SYNTHETASE
(E.C.6.1.1.11))

(Thermus
thermophilus) 		PF00587
(tRNA-synt_2b)
PF02403
(Seryl_tRNA_N) 		4 ALA A 171
LEU A 165
LEU A 417
LEU A 388
 None
 0.63A 5jqbA-1serA:
undetectable
5jqbB-1serA:
undetectable		 5jqbA-1serA:
20.65
5jqbB-1serA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sky F1-ATPASE

(Bacillus sp.
PS3) 		PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N) 		5 ARG B 415
LEU B 440
LEU B 386
TYR B 389
LEU B 382
 None
 1.50A 5jqbA-1skyB:
undetectable
5jqbB-1skyB:
undetectable		 5jqbA-1skyB:
20.82
5jqbB-1skyB:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1slm STROMELYSIN-1

(Homo sapiens) 		PF00413
(Peptidase_M10)
PF01471
(PG_binding_1) 		5 ALA A 120
LEU A 207
LEU A 218
MET A 219
LEU A 234
 None
 1.21A 5jqbA-1slmA:
1.0
5jqbB-1slmA:
undetectable		 5jqbA-1slmA:
21.26
5jqbB-1slmA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t3i PROBABLE CYSTEINE
DESULFURASE

(Synechocystis
sp.) 		PF00266
(Aminotran_5) 		5 ALA A 388
LEU A 406
LEU A 403
LEU A 329
LEU A 327
 None
 1.32A 5jqbA-1t3iA:
undetectable
5jqbB-1t3iA:
0.0		 5jqbA-1t3iA:
22.65
5jqbB-1t3iA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t4k IMMUNOGLOBULIN IGG1,
HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 ALA B  88
LEU B  18
LEU B  83
LEU B  48
LEU B  80
 None
 1.11A 5jqbA-1t4kB:
undetectable
5jqbB-1t4kB:
undetectable		 5jqbA-1t4kB:
21.66
5jqbB-1t4kB:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tdj BIOSYNTHETIC
THREONINE DEAMINASE

(Escherichia
coli) 		PF00291
(PALP)
PF00585
(Thr_dehydrat_C) 		4 ALA A 339
LEU A 359
LEU A 396
LEU A 399
 None
 0.71A 5jqbA-1tdjA:
undetectable
5jqbB-1tdjA:
undetectable		 5jqbA-1tdjA:
21.69
5jqbB-1tdjA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u05 ORF, CONSERVED
HYPOTHETICAL PROTEIN

(Shigella
flexneri) 		PF02578
(Cu-oxidase_4) 		4 ALA A 101
LEU A  36
LEU A  60
LEU A  54
 None
 0.66A 5jqbA-1u05A:
undetectable
5jqbB-1u05A:
undetectable		 5jqbA-1u05A:
21.45
5jqbB-1u05A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u0o VON WILLEBRAND
FACTOR

(Mus musculus) 		PF00092
(VWA) 		5 ARG C 686
LEU C 683
LEU C 677
LEU C 619
LEU C 621
 None
 1.35A 5jqbA-1u0oC:
0.9
5jqbB-1u0oC:
undetectable		 5jqbA-1u0oC:
20.44
5jqbB-1u0oC:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ua2 CELL DIVISION
PROTEIN KINASE 7

(Homo sapiens) 		PF00069
(Pkinase) 		4 ALA A 116
LEU A 206
LEU A 145
LEU A  98
 None
 0.74A 5jqbA-1ua2A:
undetectable
5jqbB-1ua2A:
undetectable		 5jqbA-1ua2A:
21.07
5jqbB-1ua2A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v2d GLUTAMINE
AMINOTRANSFERASE

(Thermus
thermophilus) 		PF00155
(Aminotran_1_2) 		5 ALA A 360
LEU A 322
LEU A 294
MET A 297
LEU A 314
 None
 1.44A 5jqbA-1v2dA:
undetectable
5jqbB-1v2dA:
undetectable		 5jqbA-1v2dA:
20.62
5jqbB-1v2dA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ve2 UROPORPHYRIN-III
C-METHYLTRANSFERASE

(Thermus
thermophilus) 		PF00590
(TP_methylase) 		4 LEU A 122
LEU A 129
LEU A 159
LEU A 215
 None
 0.66A 5jqbA-1ve2A:
undetectable
5jqbB-1ve2A:
undetectable		 5jqbA-1ve2A:
20.35
5jqbB-1ve2A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w66 LIPOYLTRANSFERASE

(Mycobacterium
tuberculosis) 		PF03099
(BPL_LplA_LipB) 		5 ALA A 206
LEU A  88
LEU A 161
LEU A  44
LEU A  46
 None
 1.47A 5jqbA-1w66A:
undetectable
5jqbB-1w66A:
undetectable		 5jqbA-1w66A:
22.85
5jqbB-1w66A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w6f ARYLAMINE
N-ACETYLTRANSFERASE

(Mycolicibacterium
smegmatis) 		PF00797
(Acetyltransf_2) 		5 ARG A 268
ALA A 267
LEU A  45
LEU A  44
LEU A 246
 None
 1.19A 5jqbA-1w6fA:
undetectable
5jqbB-1w6fA:
undetectable		 5jqbA-1w6fA:
20.18
5jqbB-1w6fA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wa5 IMPORTIN ALPHA
RE-EXPORTER

(Saccharomyces
cerevisiae) 		PF03378
(CAS_CSE1)
PF03810
(IBN_N)
PF08506
(Cse1) 		4 LEU C 839
LEU C 835
LEU C 953
LEU C 926
 None
 0.70A 5jqbA-1wa5C:
undetectable
5jqbB-1wa5C:
1.2		 5jqbA-1wa5C:
14.81
5jqbB-1wa5C:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wcn TRANSCRIPTION
ELONGATION PROTEIN
NUSA

(Escherichia
coli) 		PF14520
(HHH_5) 		5 ALA A 484
LEU A 467
LEU A 473
LEU A 434
LEU A 448
 None
 1.33A 5jqbA-1wcnA:
undetectable
5jqbB-1wcnA:
undetectable		 5jqbA-1wcnA:
15.31
5jqbB-1wcnA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wcx UROPORPHYRINOGEN III
SYNTHASE

(Thermus
thermophilus) 		PF02602
(HEM4) 		5 ALA A 188
LEU A 179
LEU A 175
LEU A 229
LEU A 212
 None
 1.14A 5jqbA-1wcxA:
undetectable
5jqbB-1wcxA:
undetectable		 5jqbA-1wcxA:
22.36
5jqbB-1wcxA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wid DNA-BINDING PROTEIN
RAV1

(Arabidopsis
thaliana) 		PF02362
(B3) 		5 ALA A 210
LEU A 228
LEU A 253
LEU A 187
LEU A 284
 None
 1.22A 5jqbA-1widA:
undetectable
5jqbB-1widA:
undetectable		 5jqbA-1widA:
17.38
5jqbB-1widA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus) 		PF00348
(polyprenyl_synt) 		5 ARG A 252
ALA A 247
LEU A 256
LEU A 278
LEU A 274
 None
 1.37A 5jqbA-1wmwA:
undetectable
5jqbB-1wmwA:
undetectable		 5jqbA-1wmwA:
24.05
5jqbB-1wmwA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wru 43 KDA TAIL PROTEIN

(Escherichia
virus Mu) 		PF05954
(Phage_GPD) 		4 LEU A 143
LEU A  93
TYR A 121
LEU A 153
 None
 0.64A 5jqbA-1wruA:
undetectable
5jqbB-1wruA:
undetectable		 5jqbA-1wruA:
20.76
5jqbB-1wruA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yaa ASPARTATE
AMINOTRANSFERASE

(Saccharomyces
cerevisiae) 		PF00155
(Aminotran_1_2) 		5 ALA A 403
LEU A 392
LEU A  35
LEU A 341
LEU A 337
 None
 1.47A 5jqbA-1yaaA:
undetectable
5jqbB-1yaaA:
0.0		 5jqbA-1yaaA:
23.13
5jqbB-1yaaA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yt3 RIBONUCLEASE D

(Escherichia
coli) 		PF00570
(HRDC)
PF01612
(DNA_pol_A_exo1) 		5 ALA A 329
LEU A 337
LEU A 338
LEU A 313
LEU A 366
 None
 1.29A 5jqbA-1yt3A:
undetectable
5jqbB-1yt3A:
undetectable		 5jqbA-1yt3A:
22.19
5jqbB-1yt3A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yvl SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION
1-ALPHA/BETA

(Homo sapiens) 		PF00017
(SH2)
PF01017
(STAT_alpha)
PF02864
(STAT_bind)
PF02865
(STAT_int) 		5 ARG A  31
LEU A  34
LEU A  38
LEU A  90
LEU A  64
 None
 1.49A 5jqbA-1yvlA:
undetectable
5jqbB-1yvlA:
undetectable		 5jqbA-1yvlA:
17.53
5jqbB-1yvlA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yx1 HYPOTHETICAL PROTEIN
PA2260

(Pseudomonas
aeruginosa) 		PF01261
(AP_endonuc_2) 		5 ARG A 118
LEU A 115
LEU A  80
LEU A  99
LEU A 126
 None
 1.33A 5jqbA-1yx1A:
undetectable
5jqbB-1yx1A:
undetectable		 5jqbA-1yx1A:
21.51
5jqbB-1yx1A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zud ADENYLYLTRANSFERASE
THIF

(Escherichia
coli) 		PF00899
(ThiF) 		4 ALA 1  43
LEU 1  73
LEU 1  55
LEU 1  91
 None
 0.69A 5jqbA-1zud1:
undetectable
5jqbB-1zud1:
undetectable		 5jqbA-1zud1:
19.94
5jqbB-1zud1:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a8q U8 SNORNA-BINDING
PROTEIN X29

(Xenopus laevis) 		PF00293
(NUDIX) 		5 ALA A 144
LEU A  98
LEU A  90
LEU A 154
MET A  61
 None
 1.48A 5jqbA-2a8qA:
undetectable
5jqbB-2a8qA:
undetectable		 5jqbA-2a8qA:
21.49
5jqbB-2a8qA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2amc PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN

(Thermus
thermophilus) 		PF01409
(tRNA-synt_2d)
PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5) 		5 ALA B 717
LEU B 747
LEU B 725
LEU B 772
LEU B 697
 None
 1.29A 5jqbA-2amcB:
undetectable
5jqbB-2amcB:
undetectable		 5jqbA-2amcB:
18.06
5jqbB-2amcB:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bq8 TARTRATE-RESISTANT
ACID PHOSPHATASE
TYPE 5

(Homo sapiens) 		PF00149
(Metallophos) 		5 LEU X 164
LEU X 139
LEU X 207
TYR X 215
LEU X 206
 None
 1.42A 5jqbA-2bq8X:
undetectable
5jqbB-2bq8X:
undetectable		 5jqbA-2bq8X:
23.10
5jqbB-2bq8X:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bxy MALTOOLIGOSYLTREHALO
SE TREHALOHYDROLASE

(Deinococcus
radiodurans) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48)
PF11941
(DUF3459) 		4 ALA A 357
LEU A 535
LEU A 428
LEU A 432
 None
 0.71A 5jqbA-2bxyA:
undetectable
5jqbB-2bxyA:
undetectable		 5jqbA-2bxyA:
19.40
5jqbB-2bxyA:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ctz O-ACETYL-L-HOMOSERIN
E SULFHYDRYLASE

(Thermus
thermophilus) 		PF01053
(Cys_Met_Meta_PP) 		5 ALA A 374
LEU A 416
LEU A 412
LEU A 340
LEU A 305
 None
 1.36A 5jqbA-2ctzA:
undetectable
5jqbB-2ctzA:
undetectable		 5jqbA-2ctzA:
19.82
5jqbB-2ctzA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cuy MALONYL COA-[ACYL
CARRIER PROTEIN]
TRANSACYLASE

(Thermus
thermophilus) 		PF00698
(Acyl_transf_1) 		5 ALA A  66
LEU A 108
LEU A 104
LEU A  42
LEU A  41
 None
 1.35A 5jqbA-2cuyA:
undetectable
5jqbB-2cuyA:
undetectable		 5jqbA-2cuyA:
21.17
5jqbB-2cuyA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d9j REGULATOR OF
G-PROTEIN SIGNALLING
7

(Homo sapiens) 		PF00615
(RGS) 		5 ARG A  29
ALA A  22
LEU A  49
MET A 115
LEU A  36
 None
 1.10A 5jqbA-2d9jA:
undetectable
5jqbB-2d9jA:
undetectable		 5jqbA-2d9jA:
21.59
5jqbB-2d9jA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e6k TRANSKETOLASE

(Thermus
thermophilus) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 ALA A 358
LEU A 366
LEU A 369
LEU A 499
LEU A 338
 None
 1.22A 5jqbA-2e6kA:
undetectable
5jqbB-2e6kA:
0.0		 5jqbA-2e6kA:
19.60
5jqbB-2e6kA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ef0 ORNITHINE
CARBAMOYLTRANSFERASE

(Thermus
thermophilus) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		5 ALA A 216
LEU A 152
LEU A 170
TYR A 218
LEU A 179
 None
 1.42A 5jqbA-2ef0A:
undetectable
5jqbB-2ef0A:
undetectable		 5jqbA-2ef0A:
21.69
5jqbB-2ef0A:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ehp AQ_1627 PROTEIN

(Aquifex
aeolicus) 		no annotation 4 LEU A 103
LEU A 107
LEU A  59
LEU A  32
 None
 0.73A 5jqbA-2ehpA:
undetectable
5jqbB-2ehpA:
undetectable		 5jqbA-2ehpA:
17.82
5jqbB-2ehpA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ehw HYPOTHETICAL PROTEIN
TTHB059

(Thermus
thermophilus) 		PF11483
(DUF3209) 		5 ALA A  86
LEU A  57
LEU A  61
LEU A   6
LEU A   9
 None
 1.27A 5jqbA-2ehwA:
undetectable
5jqbB-2ehwA:
undetectable		 5jqbA-2ehwA:
18.63
5jqbB-2ehwA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2epk N-ACETYL-BETA-D-GLUC
OSAMINIDASE

(Streptococcus
gordonii) 		PF00728
(Glyco_hydro_20) 		5 ALA X   2
LEU X  31
LEU X   7
LEU X  22
LEU X  62
 None
 1.42A 5jqbA-2epkX:
undetectable
5jqbB-2epkX:
0.3		 5jqbA-2epkX:
18.96
5jqbB-2epkX:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2esn PROBABLE
TRANSCRIPTIONAL
REGULATOR

(Pseudomonas
aeruginosa) 		PF00126
(HTH_1)
PF03466
(LysR_substrate) 		4 LEU A 299
LEU A 280
LEU A 130
LEU A 117
 None
 0.73A 5jqbA-2esnA:
undetectable
5jqbB-2esnA:
undetectable		 5jqbA-2esnA:
21.61
5jqbB-2esnA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fef HYPOTHETICAL PROTEIN
PA2201

(Pseudomonas
aeruginosa) 		PF08929
(DUF1911) 		5 ALA A 257
LEU A 180
LEU A 184
LEU A 222
LEU A 207
 None
 1.20A 5jqbA-2fefA:
undetectable
5jqbB-2fefA:
undetectable		 5jqbA-2fefA:
23.82
5jqbB-2fefA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gb3 ASPARTATE
AMINOTRANSFERASE

(Thermotoga
maritima) 		PF00155
(Aminotran_1_2) 		4 LEU A 168
LEU A 120
TYR A 186
LEU A 198
 None
 0.64A 5jqbA-2gb3A:
undetectable
5jqbB-2gb3A:
undetectable		 5jqbA-2gb3A:
20.72
5jqbB-2gb3A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hx0 PUTATIVE DNA-BINDING
PROTEIN

(Salmonella
enterica) 		PF03479
(DUF296) 		5 LEU A 113
LEU A 111
LEU A  85
MET A 101
LEU A  28
 None
 1.39A 5jqbA-2hx0A:
undetectable
5jqbB-2hx0A:
undetectable		 5jqbA-2hx0A:
16.92
5jqbB-2hx0A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2id5 LEUCINE RICH REPEAT
NEURONAL 6A

(Homo sapiens) 		PF07679
(I-set)
PF13306
(LRR_5)
PF13855
(LRR_8) 		5 ALA A 171
LEU A 178
LEU A 199
LEU A 159
LEU A 157
 None
 1.18A 5jqbA-2id5A:
undetectable
5jqbB-2id5A:
undetectable		 5jqbA-2id5A:
19.84
5jqbB-2id5A:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ifg HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF13855
(LRR_8)
PF16920
(TPKR_C2) 		5 ALA A 110
LEU A 103
LEU A  79
LEU A  96
LEU A 122
 None
 1.35A 5jqbA-2ifgA:
undetectable
5jqbB-2ifgA:
undetectable		 5jqbA-2ifgA:
19.57
5jqbB-2ifgA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ifg HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF13855
(LRR_8)
PF16920
(TPKR_C2) 		5 ALA A 110
LEU A 103
LEU A  79
LEU A 120
LEU A 122
 None
 1.14A 5jqbA-2ifgA:
undetectable
5jqbB-2ifgA:
undetectable		 5jqbA-2ifgA:
19.57
5jqbB-2ifgA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0n INVASIN IPAD

(Shigella
flexneri) 		PF06511
(IpaD) 		5 ALA A 198
LEU A 174
LEU A 171
LEU A 260
MET A 256
 None
 1.40A 5jqbA-2j0nA:
undetectable
5jqbB-2j0nA:
undetectable		 5jqbA-2j0nA:
20.17
5jqbB-2j0nA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jsc TRANSCRIPTIONAL
REGULATOR
RV1994C/MT2050

(Mycobacterium
tuberculosis) 		PF01022
(HTH_5) 		5 ALA A  19
LEU A  27
LEU A  86
LEU A  14
LEU A  63
 None
 1.33A 5jqbA-2jscA:
undetectable
5jqbB-2jscA:
undetectable		 5jqbA-2jscA:
15.41
5jqbB-2jscA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k7l GENERAL
TRANSCRIPTION FACTOR
IIF SUBUNIT 1

(Homo sapiens) 		PF05793
(TFIIF_alpha) 		5 ARG A 460
ALA A 458
LEU A 463
LEU A 493
LEU A 473
 None
 1.44A 5jqbA-2k7lA:
undetectable
5jqbB-2k7lA:
undetectable		 5jqbA-2k7lA:
12.77
5jqbB-2k7lA:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2km6 NACHT, LRR AND PYD
DOMAINS-CONTAINING
PROTEIN 7

(Homo sapiens) 		PF02758
(PYRIN) 		4 LEU A  24
LEU A  19
LEU A  60
LEU A  56
 None
 0.71A 5jqbA-2km6A:
undetectable
5jqbB-2km6A:
undetectable		 5jqbA-2km6A:
16.61
5jqbB-2km6A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kzb AUTOPHAGY-RELATED
PROTEIN 19

(Saccharomyces
cerevisiae) 		PF12744
(ATG19_autophagy) 		5 LEU A 358
LEU A 262
LEU A 291
TYR A 320
MET A 307
 None
 1.14A 5jqbA-2kzbA:
undetectable
5jqbB-2kzbA:
undetectable		 5jqbA-2kzbA:
17.17
5jqbB-2kzbA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nn6 EXOSOME COMPLEX
EXONUCLEASE RRP43
EXOSOME COMPONENT 6

(Homo sapiens) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		5 ALA F 164
LEU F 149
LEU F 151
LEU F  46
LEU C  88
 None
 1.24A 5jqbA-2nn6F:
undetectable
5jqbB-2nn6F:
undetectable		 5jqbA-2nn6F:
20.29
5jqbB-2nn6F:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o6q VARIABLE LYMPHOCYTE
RECEPTOR A

(Eptatretus
burgeri) 		PF13855
(LRR_8) 		5 ALA A 198
LEU A 205
LEU A 226
LEU A 186
LEU A 184
 None
 1.11A 5jqbA-2o6qA:
undetectable
5jqbB-2o6qA:
undetectable		 5jqbA-2o6qA:
23.62
5jqbB-2o6qA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o8e DNA MISMATCH REPAIR
PROTEIN MSH6

(Homo sapiens) 		PF00488
(MutS_V)
PF01624
(MutS_I)
PF05188
(MutS_II)
PF05190
(MutS_IV)
PF05192
(MutS_III) 		4 LEU B1209
LEU B1211
LEU B1091
LEU B1089
 None
 0.67A 5jqbA-2o8eB:
undetectable
5jqbB-2o8eB:
undetectable		 5jqbA-2o8eB:
15.83
5jqbB-2o8eB:
10.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o8v PHOSPHOADENOSINE
PHOSPHOSULFATE
REDUCTASE

(Escherichia
coli) 		PF01507
(PAPS_reduct) 		4 LEU A  93
LEU A  97
LEU A 194
TYR A 193
 None
 0.71A 5jqbA-2o8vA:
undetectable
5jqbB-2o8vA:
undetectable		 5jqbA-2o8vA:
20.92
5jqbB-2o8vA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2okc TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF02384
(N6_Mtase)
PF12161
(HsdM_N) 		5 ALA A 302
LEU A 289
LEU A 306
LEU A 330
LEU A 324
 None
 1.39A 5jqbA-2okcA:
undetectable
5jqbB-2okcA:
undetectable		 5jqbA-2okcA:
20.44
5jqbB-2okcA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2omv INTERNALIN-A

(Listeria
monocytogenes) 		PF08191
(LRR_adjacent)
PF12354
(Internalin_N)
PF12799
(LRR_4) 		5 ALA A 181
LEU A 188
LEU A 206
LEU A 171
LEU A 169
 None
 1.30A 5jqbA-2omvA:
undetectable
5jqbB-2omvA:
undetectable		 5jqbA-2omvA:
21.78
5jqbB-2omvA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2otu FV HEAVY CHAIN
VARIABLE DOMAIN

(Mus musculus) 		PF07686
(V-set) 		4 ALA B  92
LEU B  86
LEU B  20
LEU B  18
 None
 0.71A 5jqbA-2otuB:
undetectable
5jqbB-2otuB:
undetectable		 5jqbA-2otuB:
17.53
5jqbB-2otuB:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oy4 NEUTROPHIL
COLLAGENASE

(Homo sapiens) 		PF00413
(Peptidase_M10) 		5 ALA A 116
LEU A 203
LEU A 214
MET A 215
LEU A 229
 None
 1.16A 5jqbA-2oy4A:
1.2
5jqbB-2oy4A:
undetectable		 5jqbA-2oy4A:
17.55
5jqbB-2oy4A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ozg GCN5-RELATED
N-ACETYLTRANSFERASE

(Trichormus
variabilis) 		PF13527
(Acetyltransf_9)
PF13530
(SCP2_2) 		5 ALA A 380
LEU A 351
LEU A 346
LEU A 327
LEU A 296
 None
 1.23A 5jqbA-2ozgA:
undetectable
5jqbB-2ozgA:
undetectable		 5jqbA-2ozgA:
22.20
5jqbB-2ozgA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p1n TRANSPORT INHIBITOR
RESPONSE 1 PROTEIN

(Arabidopsis
thaliana) 		PF12937
(F-box-like) 		5 ALA B 283
LEU B 240
LEU B 270
LEU B 224
LEU B 227
 None
 1.28A 5jqbA-2p1nB:
undetectable
5jqbB-2p1nB:
undetectable		 5jqbA-2p1nB:
20.73
5jqbB-2p1nB:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p9b POSSIBLE PROLIDASE

(Bifidobacterium
longum) 		PF01979
(Amidohydro_1) 		4 ALA A 416
LEU A 360
LEU A 404
LEU A  73
 None
 0.68A 5jqbA-2p9bA:
undetectable
5jqbB-2p9bA:
0.3		 5jqbA-2p9bA:
21.72
5jqbB-2p9bA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2po4 VIRION RNA
POLYMERASE

(Escherichia
virus N4) 		no annotation 5 ALA A 522
LEU A 361
LEU A 535
MET A 502
LEU A 532
 None
 1.36A 5jqbA-2po4A:
undetectable
5jqbB-2po4A:
0.4		 5jqbA-2po4A:
14.77
5jqbB-2po4A:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pok PEPTIDASE,
M20/M25/M40 FAMILY

(Streptococcus
pneumoniae) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 ALA A 329
LEU A 239
LEU A 305
LEU A 362
LEU A 352
 None
 1.20A 5jqbA-2pokA:
0.1
5jqbB-2pokA:
undetectable		 5jqbA-2pokA:
20.56
5jqbB-2pokA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qhs LIPOYLTRANSFERASE

(Thermus
thermophilus) 		PF03099
(BPL_LplA_LipB) 		5 ALA A 200
LEU A  87
LEU A 155
LEU A  36
LEU A  38
 None
 1.42A 5jqbA-2qhsA:
undetectable
5jqbB-2qhsA:
undetectable		 5jqbA-2qhsA:
21.69
5jqbB-2qhsA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qhu LIPOYLTRANSFERASE

(Thermus
thermophilus) 		PF03099
(BPL_LplA_LipB) 		5 ALA A 200
LEU A  87
LEU A 155
LEU A  36
LEU A  38
 None
 1.41A 5jqbA-2qhuA:
undetectable
5jqbB-2qhuA:
undetectable		 5jqbA-2qhuA:
21.43
5jqbB-2qhuA:
18.31