SIMILAR PATTERNS OF AMINO ACIDS FOR 5JQ7_B_T0RB705_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a88 CHLOROPEROXIDASE L

(Streptomyces
lividans) 		PF00561
(Abhydrolase_1) 		4 LEU A 219
THR A 224
ASP A 226
LEU A 269
 None
 0.92A 5jq7B-1a88A:
undetectable		 5jq7B-1a88A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1brt BROMOPEROXIDASE A2

(Kitasatospora
aureofaciens) 		PF00561
(Abhydrolase_1) 		4 LEU A 221
THR A 226
ASP A 228
LEU A 271
 None
 0.93A 5jq7B-1brtA:
undetectable		 5jq7B-1brtA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6b GLUTATHIONE
S-TRANSFERASE

(Arabidopsis
thaliana) 		PF13409
(GST_N_2)
PF14497
(GST_C_3) 		4 LEU A  80
TYR A  79
ASP A  67
LEU A  32
 None
 1.01A 5jq7B-1e6bA:
undetectable		 5jq7B-1e6bA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hkh GAMMA LACTAMASE

(Microbacterium) 		PF00561
(Abhydrolase_1) 		4 LEU A 223
THR A 228
ASP A 230
LEU A 273
 None
 0.89A 5jq7B-1hkhA:
undetectable		 5jq7B-1hkhA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j2q PROTEASOME BETA
SUBUNIT

(Archaeoglobus
fulgidus) 		PF00227
(Proteasome) 		4 LEU H 138
THR H   2
THR H   1
LEU H   6
 None
None
CIB  H1001 (-1.9A)
None
 1.05A 5jq7B-1j2qH:
undetectable		 5jq7B-1j2qH:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1knb ADENOVIRUS TYPE 5
FIBER PROTEIN

(Human
mastadenovirus
C) 		PF00541
(Adeno_knob) 		4 LEU A 457
THR A 403
THR A 404
LEU A 413
 None
 0.89A 5jq7B-1knbA:
undetectable		 5jq7B-1knbA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ks9 2-DEHYDROPANTOATE
2-REDUCTASE

(Escherichia
coli) 		PF02558
(ApbA)
PF08546
(ApbA_C) 		4 LEU A  68
THR A 118
THR A 119
LEU A  19
 None
 1.11A 5jq7B-1ks9A:
undetectable		 5jq7B-1ks9A:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qhf PROTEIN
(PHOSPHOGLYCERATE
MUTASE)

(Saccharomyces
cerevisiae) 		PF00300
(His_Phos_1) 		4 LEU A  84
TYR A  53
THR A 175
LEU A 158
 None
 1.09A 5jq7B-1qhfA:
0.0		 5jq7B-1qhfA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qvr CLPB PROTEIN

(Thermus
thermophilus) 		PF00004
(AAA)
PF02861
(Clp_N)
PF07724
(AAA_2)
PF10431
(ClpB_D2-small) 		4 LEU A 302
THR A 306
THR A 307
LEU A 291
 None
 0.82A 5jq7B-1qvrA:
0.0		 5jq7B-1qvrA:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT

(Thauera
aromatica) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 LEU A 207
THR A 211
THR A 212
LEU A 227
 None
 0.85A 5jq7B-1sb3A:
0.0		 5jq7B-1sb3A:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cnd NADH-DEPENDENT
NITRATE REDUCTASE

(Zea mays) 		PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		4 LEU A 187
TYR A 152
THR A  65
LEU A 198
 None
None
FAD  A 271 (-4.3A)
None
 1.11A 5jq7B-2cndA:
0.0		 5jq7B-2cndA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dwu GLUTAMATE RACEMASE

(Bacillus
anthracis) 		PF01177
(Asp_Glu_race) 		4 TYR A 130
THR A 124
THR A  79
LEU A 184
 None
None
DGL  A 278 (-3.7A)
None
 1.11A 5jq7B-2dwuA:
undetectable		 5jq7B-2dwuA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ehh DIHYDRODIPICOLINATE
SYNTHASE

(Aquifex
aeolicus) 		PF00701
(DHDPS) 		4 LEU A 259
THR A  44
MET A 258
LEU A 290
 None
 1.04A 5jq7B-2ehhA:
0.0		 5jq7B-2ehhA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fcd MYOSIN LIGHT CHAIN 1

(Saccharomyces
cerevisiae) 		no annotation 4 LEU A  31
TYR A  30
THR A  60
LEU A  75
 None
 0.92A 5jq7B-2fcdA:
undetectable		 5jq7B-2fcdA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2frv PERIPLASMIC
HYDROGENASE

(Desulfovibrio
gigas) 		no annotation 4 LEU L 490
TYR L 527
THR L 411
LEU L  21
 None
 0.97A 5jq7B-2frvL:
0.0		 5jq7B-2frvL:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jfq GLUTAMATE RACEMASE

(Staphylococcus
aureus) 		PF01177
(Asp_Glu_race) 		4 TYR A 125
THR A 119
THR A  74
LEU A 112
 None
None
DGL  A1267 (-3.7A)
None
 1.03A 5jq7B-2jfqA:
undetectable		 5jq7B-2jfqA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jhe TRANSCRIPTION
REGULATOR TYRR

(Escherichia
coli) 		PF13188
(PAS_8) 		4 LEU A  54
THR A  14
MET A  55
LEU A  46
 None
AE3  A1191 (-4.3A)
None
None
 1.08A 5jq7B-2jheA:
undetectable		 5jq7B-2jheA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2no5 (S)-2-HALOACID
DEHALOGENASE IVA

(Burkholderia
cepacia) 		PF13419
(HAD_2) 		4 LEU A 105
THR A  15
ASP A 181
LEU A 139
 None
ASL  A  11 ( 3.6A)
ASL  A  11 ( 4.5A)
None
 1.05A 5jq7B-2no5A:
undetectable		 5jq7B-2no5A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pjd RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE C

(Escherichia
coli) 		PF05175
(MTS)
PF08468
(MTS_N) 		4 LEU A  11
THR A 106
ASP A  78
LEU A  33
 None
 1.08A 5jq7B-2pjdA:
undetectable		 5jq7B-2pjdA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pma UNCHARACTERIZED
PROTEIN

(Legionella
pneumophila) 		PF05618
(Zn_protease) 		4 LEU A  55
THR A  77
THR A  79
LEU A 118
 None
ACT  A 203 ( 3.8A)
ACT  A 203 (-2.9A)
None
 1.09A 5jq7B-2pmaA:
undetectable		 5jq7B-2pmaA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pw6 UNCHARACTERIZED
PROTEIN YGID

(Escherichia
coli) 		PF02900
(LigB) 		4 LEU A 159
TYR A 240
MET A 155
LEU A 101
 None
 1.00A 5jq7B-2pw6A:
undetectable		 5jq7B-2pw6A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r8r SENSOR PROTEIN

(Pseudomonas
syringae group
genomosp. 3) 		PF02702
(KdpD) 		4 LEU A 110
THR A 119
THR A 120
LEU A  74
 None
 1.02A 5jq7B-2r8rA:
undetectable		 5jq7B-2r8rA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v40 ADENYLOSUCCINATE
SYNTHETASE ISOZYME 2

(Homo sapiens) 		PF00709
(Adenylsucc_synt) 		4 LEU A 343
THR A 301
THR A 302
LEU A 436
 None
 0.90A 5jq7B-2v40A:
undetectable		 5jq7B-2v40A:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vvt GLUTAMATE RACEMASE

(Enterococcus
faecalis) 		PF01177
(Asp_Glu_race) 		4 LEU A 260
THR A 240
THR A 241
LEU A 255
 None
 0.78A 5jq7B-2vvtA:
undetectable		 5jq7B-2vvtA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vvt GLUTAMATE RACEMASE

(Enterococcus
faecalis) 		PF01177
(Asp_Glu_race) 		4 TYR A 127
THR A 121
THR A  76
LEU A 181
 None
None
DGL  A1270 (-3.8A)
None
 1.13A 5jq7B-2vvtA:
undetectable		 5jq7B-2vvtA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x4g NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE

(Pseudomonas
aeruginosa) 		PF01370
(Epimerase) 		4 LEU A 250
THR A 193
THR A 192
LEU A 322
 None
 1.05A 5jq7B-2x4gA:
undetectable		 5jq7B-2x4gA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y9e MYOSIN-2

(Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		4 LEU X 421
THR X 609
ASP X 605
LEU X 393
 None
 0.97A 5jq7B-2y9eX:
undetectable		 5jq7B-2y9eX:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a2b SERINE
PALMITOYLTRANSFERASE

(Sphingobacterium
multivorum) 		PF00155
(Aminotran_1_2) 		4 LEU A 263
THR A 241
ASP A 211
LEU A 124
 None
PLP  A 400 (-3.8A)
None
None
 1.02A 5jq7B-3a2bA:
undetectable		 5jq7B-3a2bA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bit FACT COMPLEX SUBUNIT
SPT16

(Saccharomyces
cerevisiae) 		PF00557
(Peptidase_M24)
PF14826
(FACT-Spt16_Nlob) 		4 LEU A  18
TYR A  22
THR A 130
LEU A  51
 None
 1.13A 5jq7B-3bitA:
undetectable		 5jq7B-3bitA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bzj UV ENDONUCLEASE

(Thermus
thermophilus) 		PF03851
(UvdE) 		4 LEU A 133
THR A  17
THR A  16
LEU A 130
 None
 0.81A 5jq7B-3bzjA:
undetectable		 5jq7B-3bzjA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cio TYROSINE-PROTEIN
KINASE ETK

(Escherichia
coli) 		PF13614
(AAA_31) 		4 LEU A 587
THR A 648
THR A 537
LEU A 633
 None
 1.11A 5jq7B-3cioA:
undetectable		 5jq7B-3cioA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cqf THIOL-ACTIVATED
CYTOLYSIN

(Bacillus
anthracis) 		PF01289
(Thiol_cytolysin)
PF17440
(Thiol_cytolys_C) 		4 LEU A 257
THR A 378
THR A 385
LEU A 142
 None
 0.77A 5jq7B-3cqfA:
undetectable		 5jq7B-3cqfA:
16.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3csy ENVELOPE
GLYCOPROTEIN GP2

(Zaire
ebolavirus) 		no annotation 5 LEU J 515
TYR J 517
THR J 519
THR J 520
LEU J 558
 None
 0.40A 5jq7B-3csyJ:
9.5		 5jq7B-3csyJ:
99.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dip ENOLASE

(unidentified) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LEU A 334
THR A 295
THR A  35
LEU A 109
 None
 1.11A 5jq7B-3dipA:
undetectable		 5jq7B-3dipA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ep1 PGRP-HD -
PEPTIDOGLYCAN
RECOGNITION PROTEIN
HOMOLOGUE

(Alvinella
pompejana) 		PF01510
(Amidase_2) 		4 LEU A 205
THR A 226
THR A 227
LEU A 201
 None
 1.12A 5jq7B-3ep1A:
undetectable		 5jq7B-3ep1A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fk2 GLUCOCORTICOID
RECEPTOR DNA-BINDING
FACTOR 1

(Homo sapiens) 		PF00620
(RhoGAP) 		4 LEU A1341
THR A1403
MET A1337
LEU A1361
 None
 1.07A 5jq7B-3fk2A:
undetectable		 5jq7B-3fk2A:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g48 CHAPERONE CSAA

(Bacillus
anthracis) 		PF01588
(tRNA_bind) 		4 LEU A  58
TYR A  53
ASP A  92
LEU A  33
 None
EDO  A2001 ( 4.9A)
None
None
 1.14A 5jq7B-3g48A:
undetectable		 5jq7B-3g48A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gq2 GENERAL VESICULAR
TRANSPORT FACTOR
P115

(Bos taurus) 		PF04869
(Uso1_p115_head) 		4 LEU A 458
THR A 500
ASP A 610
LEU A 474
 None
 1.10A 5jq7B-3gq2A:
undetectable		 5jq7B-3gq2A:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lat BIFUNCTIONAL
AUTOLYSIN

(Staphylococcus
epidermidis) 		PF01510
(Amidase_2) 		4 LEU A 184
TYR A 183
THR A  62
LEU A 194
 None
 0.80A 5jq7B-3latA:
undetectable		 5jq7B-3latA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mv3 COATOMER SUBUNIT
EPSILON

(Saccharomyces
cerevisiae) 		PF04733
(Coatomer_E) 		4 LEU B  91
TYR B  90
THR B 122
LEU B  60
 None
 0.84A 5jq7B-3mv3B:
undetectable		 5jq7B-3mv3B:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nwa ENVELOPE
GLYCOPROTEIN B

(Human
alphaherpesvirus
1) 		no annotation 4 TYR B 164
THR B 351
THR B 346
LEU B 234
 None
 1.09A 5jq7B-3nwaB:
0.6		 5jq7B-3nwaB:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ot5 UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Listeria
monocytogenes) 		PF02350
(Epimerase_2) 		4 LEU A 194
TYR A 189
THR A 184
LEU A 202
 None
 1.03A 5jq7B-3ot5A:
undetectable		 5jq7B-3ot5A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pty ARABINOSYLTRANSFERAS
E C

(Mycobacterium
tuberculosis) 		PF14896
(Arabino_trans_C) 		4 LEU A 766
TYR A 869
MET A 765
LEU A 883
 None
 1.09A 5jq7B-3ptyA:
undetectable		 5jq7B-3ptyA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s51 FANCONI ANEMIA GROUP
I PROTEIN HOMOLOG

(Mus musculus) 		PF14674
(FANCI_S1-cap)
PF14675
(FANCI_S1)
PF14676
(FANCI_S2)
PF14677
(FANCI_S3)
PF14678
(FANCI_S4)
PF14679
(FANCI_HD1)
PF14680
(FANCI_HD2) 		4 LEU A 630
TYR A 634
ASP A 639
LEU A 667
 None
 0.80A 5jq7B-3s51A:
0.6		 5jq7B-3s51A:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u3z MICROCEPHALIN

(Homo sapiens) 		PF00533
(BRCT)
PF16589
(BRCT_2) 		4 LEU A 781
THR A 683
THR A 649
LEU A 778
 None
 1.13A 5jq7B-3u3zA:
undetectable		 5jq7B-3u3zA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u7g BIFUNCTIONAL
POLYNUCLEOTIDE
PHOSPHATASE/KINASE

(Mus musculus) 		PF08645
(PNK3P)
PF13671
(AAA_33) 		4 LEU A 202
THR A 322
ASP A 309
LEU A 242
 None
None
MG  A 529 ( 4.5A)
None
 1.04A 5jq7B-3u7gA:
undetectable		 5jq7B-3u7gA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u9g ZINC FINGER
CCCH-TYPE ANTIVIRAL
PROTEIN 1

(Rattus
norvegicus) 		no annotation 4 THR A  67
THR A  68
ASP A  47
LEU A 193
 None
 1.10A 5jq7B-3u9gA:
undetectable		 5jq7B-3u9gA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ucq AMYLOSUCRASE

(Deinococcus
geothermalis) 		PF00128
(Alpha-amylase) 		4 LEU A 174
THR A 104
ASP A 151
LEU A 273
 None
 0.74A 5jq7B-3ucqA:
undetectable		 5jq7B-3ucqA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vsv XYLOSIDASE

(Thermoanaerobacterium
saccharolyticum) 		PF13229
(Beta_helix) 		4 LEU A 142
TYR A 184
THR A 181
ASP A 177
 None
 1.06A 5jq7B-3vsvA:
undetectable		 5jq7B-3vsvA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vsz RICIN B LECTIN

(Ruminiclostridium
thermocellum) 		PF04616
(Glyco_hydro_43)
PF14200
(RicinB_lectin_2) 		4 LEU A 205
TYR A 192
THR A 187
LEU A 222
 None
 1.06A 5jq7B-3vszA:
undetectable		 5jq7B-3vszA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zr8 AVR3A11

(Phytophthora
capsici) 		PF16810
(RXLR) 		4 LEU X 110
TYR X 122
THR X 127
ASP X 130
 None
 1.09A 5jq7B-3zr8X:
undetectable		 5jq7B-3zr8X:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zs6 PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Burkholderia
pseudomallei) 		PF00496
(SBP_bac_5) 		4 LEU A 230
THR A 259
THR A  55
ASP A  53
 None
 1.11A 5jq7B-3zs6A:
undetectable		 5jq7B-3zs6A:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ap3 STEROID
MONOOXYGENASE

(Rhodococcus
rhodochrous) 		PF00743
(FMO-like) 		4 LEU A 385
TYR A 383
THR A 378
THR A 379
 None
 1.07A 5jq7B-4ap3A:
undetectable		 5jq7B-4ap3A:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bkx HISTONE DEACETYLASE
1
METASTASIS-ASSOCIATE
D PROTEIN MTA1

(Homo sapiens) 		PF00249
(Myb_DNA-binding)
PF00850
(Hist_deacetyl)
PF01448
(ELM2) 		4 TYR B 336
THR A 332
THR A 333
LEU B  41
 None
 1.12A 5jq7B-4bkxB:
undetectable		 5jq7B-4bkxB:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bug ANCILLARY PROTEIN 1

(Streptococcus
pyogenes) 		PF08341
(TED) 		4 LEU A 513
TYR A 516
THR A 519
THR A 467
 None
 1.14A 5jq7B-4bugA:
undetectable		 5jq7B-4bugA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bva THIOMORPHOLINE-CARBO
XYLATE DEHYDROGENASE

(Mus musculus) 		PF02423
(OCD_Mu_crystall) 		4 LEU A 271
TYR A 246
THR A 287
THR A 286
 None
None
K  A1315 (-3.0A)
None
 0.86A 5jq7B-4bvaA:
undetectable		 5jq7B-4bvaA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cek REGULATOR OF
NONSENSE TRANSCRIPTS
2

(Homo sapiens) 		PF02854
(MIF4G) 		4 LEU A 673
ASP A 585
MET A 678
LEU A 640
 None
 1.09A 5jq7B-4cekA:
undetectable		 5jq7B-4cekA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ebz CHITIN ELICITOR
RECEPTOR KINASE 1

(Arabidopsis
thaliana) 		PF01476
(LysM) 		4 LEU A  51
TYR A 121
THR A 125
THR A 126
 None
None
NAG  A 805 (-4.6A)
NAG  A 805 ( 4.1A)
 1.02A 5jq7B-4ebzA:
undetectable		 5jq7B-4ebzA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fe4 XYLOSE OPERON
REGULATORY PROTEIN

(Escherichia
coli) 		PF12833
(HTH_18)
PF13377
(Peripla_BP_3) 		4 LEU A 365
TYR A 369
THR A 379
THR A 378
 None
 0.92A 5jq7B-4fe4A:
undetectable		 5jq7B-4fe4A:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fzi PROSTAGLANDIN F
SYNTHASE

(Trypanosoma
cruzi) 		PF00248
(Aldo_ket_red) 		4 LEU A 128
TYR A 108
THR A  77
THR A  49
 None
 1.10A 5jq7B-4fziA:
undetectable		 5jq7B-4fziA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g4i 4-O-METHYL-GLUCURONO
YL METHYLESTERASE

(Thermothelomyces
thermophila) 		no annotation 4 LEU A  74
THR A 283
ASP A 249
LEU A 292
 None
 1.13A 5jq7B-4g4iA:
undetectable		 5jq7B-4g4iA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hse CHAPERONE PROTEIN
CLPB

(Thermus
thermophilus) 		PF00004
(AAA) 		4 LEU A 302
THR A 306
THR A 307
LEU A 291
 None
 1.11A 5jq7B-4hseA:
undetectable		 5jq7B-4hseA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4knk BIFUNCTIONAL
AUTOLYSIN

(Staphylococcus
aureus) 		PF01510
(Amidase_2) 		4 LEU A 389
TYR A 388
THR A 267
LEU A 399
 None
 0.74A 5jq7B-4knkA:
undetectable		 5jq7B-4knkA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l3r UNCHARACTERIZED
PROTEIN

(Bacteroides
eggerthii) 		PF16139
(DUF4847) 		4 LEU A  43
THR A  47
THR A  48
LEU A  73
 None
 1.02A 5jq7B-4l3rA:
undetectable		 5jq7B-4l3rA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p3z COPN

(Chlamydia
pneumoniae) 		PF07201
(HrpJ) 		4 LEU A 240
TYR A 207
THR A 178
LEU A 220
 None
 0.63A 5jq7B-4p3zA:
undetectable		 5jq7B-4p3zA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p4g SHIKIMATE
5-DEHYDROGENASE AROE
(5-DEHYDROSHIKIMATE
REDUCTASE)

(Mycobacterium
tuberculosis) 		PF08501
(Shikimate_dh_N) 		4 LEU A 178
THR A 168
ASP A 143
LEU A 204
 BR  A 305 ( 4.8A)
None
None
None
 1.04A 5jq7B-4p4gA:
undetectable		 5jq7B-4p4gA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4per RIBONUCLEASE
INHIBITOR

(Gallus gallus) 		PF13516
(LRR_6) 		4 LEU A  87
THR A  27
ASP A   4
LEU A  63
 None
 1.13A 5jq7B-4perA:
undetectable		 5jq7B-4perA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pfz 5-CARBOXYMETHYL-2-HY
DROXYMUCONATE
DELTA-ISOMERASE

(Mycolicibacterium
smegmatis) 		PF01557
(FAA_hydrolase)
PF10370
(DUF2437) 		4 LEU A  72
THR A 269
THR A 263
LEU A  67
 None
 1.05A 5jq7B-4pfzA:
undetectable		 5jq7B-4pfzA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wep PUTATIVE
OSMOPROTECTANT
UPTAKE SYSTEM
SUBSTRATE-BINDING
PROTEIN OSMF

(Escherichia
coli) 		PF04069
(OpuAC) 		4 LEU A 154
TYR A 153
ASP A 137
LEU A 186
 None
 1.01A 5jq7B-4wepA:
undetectable		 5jq7B-4wepA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ypv EST8

(Parvibaculum) 		PF07859
(Abhydrolase_3) 		4 LEU A  81
THR A  96
ASP A  42
LEU A 184
 None
 1.03A 5jq7B-4ypvA:
undetectable		 5jq7B-4ypvA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 5

(Homo sapiens) 		PF12862
(ANAPC5) 		4 LEU O 567
TYR O 545
ASP O 517
LEU O 563
 None
 1.02A 5jq7B-5a31O:
undetectable		 5jq7B-5a31O:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b0l MOEN5,DNA-BINDING
PROTEIN 7D

(Streptomyces
viridosporus;
Sulfolobus
solfataricus) 		no annotation 4 LEU A  59
THR A  46
THR A  47
LEU A  99
 None
 1.12A 5jq7B-5b0lA:
undetectable		 5jq7B-5b0lA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cer BD0816

(Bdellovibrio
bacteriovorus) 		PF02113
(Peptidase_S13) 		4 LEU A 112
THR A 128
ASP A 130
LEU A 423
 None
 1.06A 5jq7B-5cerA:
undetectable		 5jq7B-5cerA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d1x IRON-REGULATED
SURFACE DETERMINANT
PROTEIN B
P5 HEAVY CHAIN

(Homo sapiens;
Staphylococcus
aureus) 		PF05031
(NEAT)
PF07686
(V-set) 		4 LEU E 345
TYR C 100
THR C  97
ASP C 101
 None
 1.13A 5jq7B-5d1xE:
undetectable		 5jq7B-5d1xE:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ez3 ACYL-COA
DEHYDROGENASE

(Brucella
melitensis) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M) 		4 LEU A 344
THR A 531
THR A 530
MET A 345
 None
 1.10A 5jq7B-5ez3A:
undetectable		 5jq7B-5ez3A:
15.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fhc ENVELOPE
GLYCOPROTEIN

(Zaire
ebolavirus) 		no annotation 4 LEU J 515
TYR J 517
MET J 548
LEU J 558
 None
 0.81A 5jq7B-5fhcJ:
9.4		 5jq7B-5fhcJ:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fhc ENVELOPE
GLYCOPROTEIN

(Zaire
ebolavirus) 		no annotation 5 LEU J 515
TYR J 517
THR J 519
THR J 520
LEU J 558
 None
 0.50A 5jq7B-5fhcJ:
9.4		 5jq7B-5fhcJ:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fzp DISPASE
AUTOLYSIS-INDUCING
PROTEIN

(Streptomyces
mobaraensis) 		no annotation 4 LEU A 341
THR A  24
THR A  25
ASP A  27
 None
GOL  A1348 (-4.5A)
GOL  A1348 (-3.0A)
None
 1.12A 5jq7B-5fzpA:
undetectable		 5jq7B-5fzpA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gw8 HYPOTHETICAL
SECRETORY LIPASE
(FAMILY 3)

(Malassezia
globosa) 		PF01764
(Lipase_3) 		4 LEU A 178
THR A 232
ASP A 228
LEU A 220
 None
 1.04A 5jq7B-5gw8A:
undetectable		 5jq7B-5gw8A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h3h ABHYDROLASE
DOMAIN-CONTAINING
PROTEIN

(Exiguobacterium
antarcticum) 		PF00561
(Abhydrolase_1)
PF08386
(Abhydrolase_4) 		4 LEU A  44
TYR A  51
ASP A  55
LEU A 262
 None
 0.98A 5jq7B-5h3hA:
undetectable		 5jq7B-5h3hA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hp6 EXTRACELLULAR
ARABINANASE

(Geobacillus
stearothermophilus) 		PF04616
(Glyco_hydro_43)
PF13385
(Laminin_G_3)
PF16369
(GH43_C) 		4 LEU A 775
THR A 722
ASP A 818
LEU A 714
 None
 0.97A 5jq7B-5hp6A:
undetectable		 5jq7B-5hp6A:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hx9 BETA-LACTAMASE

(Burkholderia
vietnamiensis) 		PF13354
(Beta-lactamase2) 		4 LEU A  45
THR A 243
THR A 237
LEU A  37
 None
 1.11A 5jq7B-5hx9A:
undetectable		 5jq7B-5hx9A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i33 ADENYLOSUCCINATE
SYNTHETASE

(Cryptococcus
neoformans) 		PF00709
(Adenylsucc_synt) 		4 LEU A 317
THR A 275
THR A 276
LEU A 410
 None
 0.95A 5jq7B-5i33A:
undetectable		 5jq7B-5i33A:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ig9 ATP GRASP LIGASE

(Microcystis
aeruginosa) 		no annotation 4 LEU A 113
TYR A 277
THR A 219
LEU A 321
 None
 1.13A 5jq7B-5ig9A:
undetectable		 5jq7B-5ig9A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ihv BETA-LACTAMASE

(Burkholderia
ambifaria) 		PF13354
(Beta-lactamase2) 		4 LEU A  22
THR A 220
THR A 214
LEU A  14
 None
 1.08A 5jq7B-5ihvA:
undetectable		 5jq7B-5ihvA:
21.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jq3 ENVELOPE
GLYCOPROTEIN 2

(Zaire
ebolavirus) 		PF07921
(Fibritin_C) 		5 LEU B 515
TYR B 517
THR B 519
THR B 520
LEU B 558
 None
 0.42A 5jq7B-5jq3B:
12.7		 5jq7B-5jq3B:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ken EBOLA SURFACE
GLYCOPROTEIN, GP2

(Zaire
ebolavirus) 		no annotation 4 LEU B 515
TYR B 517
THR B 520
LEU B 558
 None
 0.80A 5jq7B-5kenB:
8.7		 5jq7B-5kenB:
99.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ken EBOLA SURFACE
GLYCOPROTEIN, GP2

(Zaire
ebolavirus) 		no annotation 4 TYR B 517
THR B 519
THR B 520
LEU B 558
 None
 0.80A 5jq7B-5kenB:
8.7		 5jq7B-5kenB:
99.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kis RHS2

(Yersinia
entomophaga) 		no annotation 4 LEU B 595
THR B 619
THR B 396
LEU B 329
 None
 1.06A 5jq7B-5kisB:
undetectable		 5jq7B-5kisB:
10.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lf9 NUCLEOSIDE
DIPHOSPHATE-LINKED
MOIETY X MOTIF 22

(Homo sapiens) 		no annotation 4 LEU A 208
TYR A 225
THR A 129
ASP A 132
 None
 0.98A 5jq7B-5lf9A:
0.2		 5jq7B-5lf9A:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nii THIOREDOXIN
REDUCTASE

(Desulfovibrio
vulgaris) 		no annotation 4 LEU A 201
THR A 171
ASP A 194
LEU A 207
 None
 1.06A 5jq7B-5niiA:
undetectable		 5jq7B-5niiA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sz8 HEMOLYSIN

(Proteus
mirabilis) 		PF05860
(Haemagg_act) 		4 LEU A 183
THR A 190
THR A 191
LEU A 181
 None
 1.05A 5jq7B-5sz8A:
undetectable		 5jq7B-5sz8A:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ve9 MICROTUBULE-ACTIN
CROSS-LINKING FACTOR
1, ISOFORMS 1/2/3/5

(Homo sapiens) 		PF13499
(EF-hand_7) 		4 THR A7077
THR A7078
MET A7039
LEU A7106
 None
 0.98A 5jq7B-5ve9A:
undetectable		 5jq7B-5ve9A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vgj 1FD6-V1V2-WITO

(Human
immunodeficiency
virus 1) 		PF00516
(GP120)
PF01378
(IgG_binding_B) 		4 LEU G 129
THR G 161
THR G 162
LEU G 193
 None
 1.13A 5jq7B-5vgjG:
undetectable		 5jq7B-5vgjG:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vo5 COILED-COIL AND C2
DOMAIN-CONTAINING
PROTEIN
1-LIKE,GH13992P

(Drosophila
melanogaster) 		PF03357
(Snf7) 		4 LEU A   8
TYR A  48
MET A   4
LEU A  59
 None
 1.05A 5jq7B-5vo5A:
undetectable		 5jq7B-5vo5A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wvg CHITINASE

(Ostrinia
furnacalis) 		no annotation 4 LEU A 890
THR A 559
MET A 886
LEU A 853
 None
 1.14A 5jq7B-5wvgA:
undetectable		 5jq7B-5wvgA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x8j THYMIDYLATE KINASE

(Thermus
thermophilus) 		no annotation 4 LEU A  81
THR A   7
ASP A  94
LEU A  78
 None
 0.97A 5jq7B-5x8jA:
undetectable		 5jq7B-5x8jA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ywp JEV E PROTEIN

(Japanese
encephalitis
virus) 		no annotation 4 LEU A 289
THR A  40
THR A 356
LEU A  23
 None
 1.11A 5jq7B-5ywpA:
undetectable		 5jq7B-5ywpA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zqe -

(-) 		no annotation 4 LEU A 249
THR A 226
ASP A 161
LEU A 174
 None
CES  A 301 (-4.4A)
None
None
 0.86A 5jq7B-5zqeA:
undetectable		 5jq7B-5zqeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6egt GLYCOPROTEIN

(Rift Valley
fever
phlebovirus) 		no annotation 4 THR A 984
THR A 989
ASP A 987
LEU A1114
 None
 1.09A 5jq7B-6egtA:
undetectable		 5jq7B-6egtA:
15.12