SIMILAR PATTERNS OF AMINO ACIDS FOR 5JQ7_B_T0RB705_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b72 PROTEIN (HOMEOBOX
PROTEIN HOX-B1)

(Homo sapiens) 		PF00046
(Homeobox) 		5 VAL A 247
LEU A 218
GLU A 244
ALA A 237
LEU A 228
 None
 1.20A 5jq7A-1b72A:
undetectable		 5jq7A-1b72A:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c4t PROTEIN
(DIHYDROLIPOAMIDE
SUCCINYLTRANSFERASE)

(Escherichia
coli) 		PF00198
(2-oxoacid_dh) 		5 VAL A 241
LEU A 245
ALA A 240
LEU A 345
LEU A 369
 None
 1.33A 5jq7A-1c4tA:
0.0		 5jq7A-1c4tA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gae D-GLYCERALDEHYDE-3-P
HOSPHATE
DEHYDROGENASE

(Escherichia
coli) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 VAL O 305
LEU O 307
ALA O 299
LEU O 246
 None
 0.59A 5jq7A-1gaeO:
0.0		 5jq7A-1gaeO:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gr0 INOSITOL-3-PHOSPHATE
SYNTHASE

(Mycobacterium
tuberculosis) 		PF01658
(Inos-1-P_synth) 		4 VAL A  21
LEU A 146
LEU A 142
LEU A 134
 NAD  A1000 ( 4.8A)
None
None
None
 0.65A 5jq7A-1gr0A:
0.0		 5jq7A-1gr0A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1idm 3-ISOPROPYLMALATE
DEHYDROGENASE

(Thermus
thermophilus) 		PF00180
(Iso_dh) 		4 VAL A   3
GLU A  65
ALA A  66
LEU A  34
 None
 0.44A 5jq7A-1idmA:
0.0		 5jq7A-1idmA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jl5 OUTER PROTEIN YOPM

(Yersinia pestis) 		PF12468
(TTSSLRR) 		4 VAL A1118
LEU A1123
ALA A1098
LEU A1113
 None
 0.60A 5jq7A-1jl5A:
0.0		 5jq7A-1jl5A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jl5 OUTER PROTEIN YOPM

(Yersinia pestis) 		PF12468
(TTSSLRR) 		4 VAL A1264
LEU A1269
ALA A1244
LEU A1259
 None
 0.66A 5jq7A-1jl5A:
0.0		 5jq7A-1jl5A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jl5 OUTER PROTEIN YOPM

(Yersinia pestis) 		PF12468
(TTSSLRR) 		4 VAL A1324
LEU A1329
ALA A1304
LEU A1319
 None
 0.57A 5jq7A-1jl5A:
0.0		 5jq7A-1jl5A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jl5 OUTER PROTEIN YOPM

(Yersinia pestis) 		PF12468
(TTSSLRR) 		4 VAL A1364
LEU A1369
ALA A1344
LEU A1359
 None
 0.59A 5jq7A-1jl5A:
0.0		 5jq7A-1jl5A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ln1 PHOSPHATIDYLCHOLINE
TRANSFER PROTEIN

(Homo sapiens) 		PF01852
(START) 		4 VAL A 132
LEU A 134
ALA A 160
LEU A 123
 None
 0.62A 5jq7A-1ln1A:
0.0		 5jq7A-1ln1A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lpe APOLIPOPROTEIN E3

(Homo sapiens) 		PF01442
(Apolipoprotein) 		5 ARG A 114
VAL A 111
LEU A  60
LEU A 141
LEU A 137
 None
 1.24A 5jq7A-1lpeA:
undetectable		 5jq7A-1lpeA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1puf HOMEOBOX PROTEIN
HOX-A9

(Mus musculus) 		PF00046
(Homeobox) 		5 VAL A 249
LEU A 220
GLU A 246
ALA A 239
LEU A 230
 None
 1.25A 5jq7A-1pufA:
undetectable		 5jq7A-1pufA:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pyb METHIONYL-TRNA
SYNTHETASE BETA
SUBUNIT

(Aquifex
aeolicus) 		PF01588
(tRNA_bind) 		4 ARG A  46
VAL A  48
LEU A  39
LEU A  41
 None
 0.61A 5jq7A-1pybA:
undetectable		 5jq7A-1pybA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v9a UROPORPHYRIN-III
C-METHYLTRANSFERASE

(Thermus
thermophilus) 		PF00590
(TP_methylase) 		4 VAL A 157
LEU A 123
ALA A 134
LEU A 216
 None
None
None
SAH  A 501 (-4.4A)
 0.64A 5jq7A-1v9aA:
undetectable		 5jq7A-1v9aA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xn4 RIBONUCLEASE MAR1

(Leishmania
major) 		PF00857
(Isochorismatase) 		4 VAL A 127
LEU A 129
ALA A 102
LEU A 121
 None
 0.68A 5jq7A-1xn4A:
0.0		 5jq7A-1xn4A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aka DYNAMIN-1

(Rattus
norvegicus) 		PF00350
(Dynamin_N)
PF01031
(Dynamin_M) 		4 VAL B 124
ALA B  81
LEU B  71
LEU B  69
 None
 0.51A 5jq7A-2akaB:
undetectable		 5jq7A-2akaB:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bg9 ACETYLCHOLINE
RECEPTOR PROTEIN,
DELTA CHAIN

(Torpedo
marmorata) 		PF02931
(Neur_chan_LBD)
PF02932
(Neur_chan_memb) 		4 VAL C  56
ALA C 124
LEU C  37
LEU C  35
 None
 0.67A 5jq7A-2bg9C:
undetectable		 5jq7A-2bg9C:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bnh RIBONUCLEASE
INHIBITOR

(Sus scrofa) 		PF13516
(LRR_6) 		4 VAL A 315
LEU A 320
LEU A 341
LEU A 338
 None
 0.66A 5jq7A-2bnhA:
undetectable		 5jq7A-2bnhA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dno TRINUCLEOTIDE REPEAT
CONTAINING 4 VARIANT

(Homo sapiens) 		PF00076
(RRM_1) 		4 VAL A  75
ALA A 114
LEU A 144
LEU A 137
 None
 0.67A 5jq7A-2dnoA:
undetectable		 5jq7A-2dnoA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dwc 433AA LONG
HYPOTHETICAL
PHOSPHORIBOSYLGLYCIN
AMIDE FORMYL
TRANSFERASE

(Pyrococcus
horikoshii) 		PF02222
(ATP-grasp) 		4 VAL A 373
LEU A 375
ALA A 390
LEU A 366
 None
 0.57A 5jq7A-2dwcA:
undetectable		 5jq7A-2dwcA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e6k TRANSKETOLASE

(Thermus
thermophilus) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 ARG A 642
VAL A 643
LEU A 546
GLU A 645
ALA A 646
 None
 1.23A 5jq7A-2e6kA:
undetectable		 5jq7A-2e6kA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fym ENOLASE

(Escherichia
coli) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		5 VAL A 224
LEU A 215
GLU A 227
ALA A 223
LEU A 192
 None
 1.46A 5jq7A-2fymA:
undetectable		 5jq7A-2fymA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l9r HOMEOBOX PROTEIN
NKX-3.1

(Homo sapiens) 		PF00046
(Homeobox) 		5 VAL A  48
LEU A  19
GLU A  45
ALA A  38
LEU A  29
 None
 1.29A 5jq7A-2l9rA:
undetectable		 5jq7A-2l9rA:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mk4 OPEN READING FRAME 2

(Aeromonas
sobria) 		no annotation 5 VAL A  68
LEU A  96
GLU A  69
ALA A  70
LEU A 111
 None
 1.00A 5jq7A-2mk4A:
undetectable		 5jq7A-2mk4A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nq3 ITCHY HOMOLOG E3
UBIQUITIN PROTEIN
LIGASE

(Homo sapiens) 		PF00168
(C2) 		4 VAL A 118
LEU A 120
LEU A 139
LEU A 113
 None
 0.57A 5jq7A-2nq3A:
undetectable		 5jq7A-2nq3A:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2okc TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF02384
(N6_Mtase)
PF12161
(HsdM_N) 		4 VAL A 304
LEU A 306
ALA A 258
LEU A 296
 None
 0.66A 5jq7A-2okcA:
undetectable		 5jq7A-2okcA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2prr ALKYLHYDROPEROXIDASE
AHPD CORE:
UNCHARACTERIZED
PEROXIDASE-RELATED
PROTEIN

(Cupriavidus
pinatubonensis) 		PF02627
(CMD) 		5 VAL A 110
LEU A  97
ALA A 111
LEU A 127
LEU A 131
 None
 1.09A 5jq7A-2prrA:
undetectable		 5jq7A-2prrA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r3s UNCHARACTERIZED
PROTEIN

(Nostoc
punctiforme) 		PF00891
(Methyltransf_2)
PF16864
(Dimerisation2) 		4 VAL A 266
ALA A 332
LEU A 237
LEU A 241
 None
 0.58A 5jq7A-2r3sA:
undetectable		 5jq7A-2r3sA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r6i UNCHARACTERIZED
PROTEIN ATU1473

(Agrobacterium
fabrum) 		PF07542
(ATP12) 		5 VAL A  97
LEU A  64
ALA A 100
LEU A  71
LEU A 260
 None
 1.09A 5jq7A-2r6iA:
undetectable		 5jq7A-2r6iA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v1u CELL DIVISION
CONTROL PROTEIN 6
HOMOLOG

(Aeropyrum
pernix) 		PF09079
(Cdc6_C)
PF13191
(AAA_16) 		4 ARG A 225
LEU A 235
GLU A 228
ALA A 229
 ADP  A1400 (-3.3A)
None
None
None
 0.49A 5jq7A-2v1uA:
undetectable		 5jq7A-2v1uA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vou 2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE

(Paenarthrobacter
nicotinovorans) 		PF00070
(Pyr_redox) 		4 VAL A 130
ALA A 142
LEU A 123
LEU A 120
 None
None
None
FAD  A1395 (-4.6A)
 0.62A 5jq7A-2vouA:
undetectable		 5jq7A-2vouA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wpg AMYLOSUCRASE OR
ALPHA AMYLASE

(Xanthomonas
campestris) 		PF00128
(Alpha-amylase)
PF11941
(DUF3459) 		4 VAL A 586
LEU A 626
ALA A 576
LEU A 634
 None
 0.68A 5jq7A-2wpgA:
undetectable		 5jq7A-2wpgA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wsm HYDROGENASE
EXPRESSION/FORMATION
PROTEIN (HYPB)

(Archaeoglobus
fulgidus) 		PF02492
(cobW) 		4 ARG A  49
LEU A 113
GLU A  52
LEU A 195
 None
 0.66A 5jq7A-2wsmA:
undetectable		 5jq7A-2wsmA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xly CLOQ

(Streptomyces
roseochromogenus) 		PF11468
(PTase_Orf2) 		4 VAL A 173
ALA A 162
LEU A 220
LEU A 222
 None
 0.59A 5jq7A-2xlyA:
undetectable		 5jq7A-2xlyA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yq4 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE

(Lactobacillus
delbrueckii) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 VAL A  49
LEU A  51
ALA A   5
LEU A  66
 None
 0.57A 5jq7A-2yq4A:
undetectable		 5jq7A-2yq4A:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z7x TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Homo sapiens) 		PF11921
(DUF3439)
PF13855
(LRR_8) 		4 VAL A 464
LEU A 469
LEU A 482
LEU A 479
 None
 0.66A 5jq7A-2z7xA:
undetectable		 5jq7A-2z7xA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z81 TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Mus musculus) 		PF11921
(DUF3439)
PF13306
(LRR_5)
PF13516
(LRR_6)
PF13855
(LRR_8) 		4 VAL A 464
LEU A 469
LEU A 482
LEU A 479
 None
 0.62A 5jq7A-2z81A:
undetectable		 5jq7A-2z81A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zfu CEREBRAL PROTEIN 1

(Homo sapiens) 		PF05148
(Methyltransf_8) 		4 VAL A 390
LEU A 388
LEU A 366
LEU A 448
 None
 0.69A 5jq7A-2zfuA:
undetectable		 5jq7A-2zfuA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aup BASIC 7S GLOBULIN

(Glycine max) 		PF14541
(TAXi_C)
PF14543
(TAXi_N) 		4 VAL A 316
LEU A 318
LEU A 335
LEU A 346
 None
 0.44A 5jq7A-3aupA:
undetectable		 5jq7A-3aupA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aw5 MULTICOPPER OXIDASE

(Pyrobaculum
aerophilum) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 VAL A 276
LEU A 278
LEU A 220
LEU A 222
 None
 0.59A 5jq7A-3aw5A:
undetectable		 5jq7A-3aw5A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bre PROBABLE
TWO-COMPONENT
RESPONSE REGULATOR

(Pseudomonas
aeruginosa) 		PF00072
(Response_reg)
PF00990
(GGDEF) 		5 VAL A  34
LEU A 129
GLU A  32
ALA A  33
LEU A  23
 None
 1.22A 5jq7A-3breA:
undetectable		 5jq7A-3breA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cps GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE

(Cryptosporidium
parvum) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 VAL A 326
LEU A 328
ALA A 320
LEU A 267
 None
 0.47A 5jq7A-3cpsA:
undetectable		 5jq7A-3cpsA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cvr INVASION PLASMID
ANTIGEN

(Shigella
flexneri) 		PF12468
(TTSSLRR)
PF14496
(NEL) 		4 VAL A 127
LEU A 132
ALA A 107
LEU A 122
 None
 0.65A 5jq7A-3cvrA:
undetectable		 5jq7A-3cvrA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d6c THERMONUCLEASE

(Staphylococcus
aureus) 		PF00565
(SNase) 		4 VAL A  23
LEU A  25
ALA A  17
LEU A  36
 None
 0.68A 5jq7A-3d6cA:
undetectable		 5jq7A-3d6cA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d6c THERMONUCLEASE

(Staphylococcus
aureus) 		PF00565
(SNase) 		4 VAL A  23
LEU A  25
ALA A  17
LEU A 103
 None
 0.65A 5jq7A-3d6cA:
undetectable		 5jq7A-3d6cA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g06 SSPH2 (LEUCINE-RICH
REPEAT PROTEIN)

(Salmonella
enterica) 		PF14496
(NEL) 		4 VAL A 349
LEU A 354
ALA A 329
LEU A 344
 None
 0.56A 5jq7A-3g06A:
undetectable		 5jq7A-3g06A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g06 SSPH2 (LEUCINE-RICH
REPEAT PROTEIN)

(Salmonella
enterica) 		PF14496
(NEL) 		4 VAL A 389
LEU A 394
ALA A 369
LEU A 384
 None
 0.59A 5jq7A-3g06A:
undetectable		 5jq7A-3g06A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g8a RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G

(Thermus
thermophilus) 		PF02527
(GidB) 		4 VAL A 224
ALA A 182
LEU A 206
LEU A 199
 None
 0.42A 5jq7A-3g8aA:
undetectable		 5jq7A-3g8aA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gbd SUCROSE ISOMERASE
SMUA FROM
PROTAMINOBACTER
RUBRUM

(Serratia
plymuthica) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		4 VAL A 521
LEU A 561
ALA A 508
LEU A 571
 None
 0.65A 5jq7A-3gbdA:
undetectable		 5jq7A-3gbdA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3go4 PROTEIN OF UNKNOWN
FUNCTION DUF574

(Streptomyces
avermitilis) 		PF04672
(Methyltransf_19) 		4 ARG A 152
ALA A 148
LEU A 155
LEU A 157
 None
 0.67A 5jq7A-3go4A:
undetectable		 5jq7A-3go4A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR CWF11

(Schizosaccharomyces
pombe) 		PF13087
(AAA_12)
PF16399
(Aquarius_N) 		4 ARG X1004
VAL X1006
LEU X1008
LEU X 765
 None
 0.55A 5jq7A-3jb9X:
undetectable		 5jq7A-3jb9X:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jsj PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
avermitilis) 		PF00440
(TetR_N) 		5 ARG A 104
VAL A 108
LEU A 112
ALA A 107
LEU A  59
 EDO  A 191 (-2.6A)
None
None
None
None
 1.27A 5jq7A-3jsjA:
undetectable		 5jq7A-3jsjA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l12 PUTATIVE
GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE

(Ruegeria
pomeroyi) 		PF03009
(GDPD) 		5 VAL A 169
LEU A 128
ALA A 168
LEU A 149
LEU A 191
 None
 1.31A 5jq7A-3l12A:
undetectable		 5jq7A-3l12A:
24.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l43 DYNAMIN-3

(Homo sapiens) 		PF00350
(Dynamin_N)
PF01031
(Dynamin_M) 		4 VAL A 124
ALA A  81
LEU A  71
LEU A  69
 None
 0.56A 5jq7A-3l43A:
undetectable		 5jq7A-3l43A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m7o LYMPHOCYTE ANTIGEN
86

(Mus musculus) 		PF02221
(E1_DerP2_DerF2) 		4 VAL A  40
LEU A  38
ALA A  32
LEU A 142
 None
None
None
L9R  A 301 (-4.0A)
 0.66A 5jq7A-3m7oA:
undetectable		 5jq7A-3m7oA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nct PROTEIN PSIB

(Escherichia
coli) 		PF06290
(PsiB) 		5 VAL A 113
LEU A  89
GLU A 111
ALA A 112
LEU A  40
 None
 1.41A 5jq7A-3nctA:
undetectable		 5jq7A-3nctA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oep PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0988

(Thermus
thermophilus) 		PF02626
(CT_A_B)
PF02682
(CT_C_D) 		5 VAL A 103
LEU A 133
GLU A 101
ALA A 102
LEU A  89
 None
 1.37A 5jq7A-3oepA:
undetectable		 5jq7A-3oepA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rrv ENOYL-COA
HYDRATASE/ISOMERASE

(Mycobacterium
avium) 		PF00378
(ECH_1) 		5 VAL A  93
LEU A 121
GLU A  91
LEU A 227
LEU A 231
 None
 1.33A 5jq7A-3rrvA:
undetectable		 5jq7A-3rrvA:
19.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3s88 ENVELOPE
GLYCOPROTEIN

(Sudan
ebolavirus) 		PF01611
(Filo_glycop) 		6 VAL I  66
LEU I  68
GLU I 100
ALA I 101
LEU I 184
LEU I 186
 None
 0.53A 5jq7A-3s88I:
28.5		 5jq7A-3s88I:
63.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tzw POLYKETIDE SYNTHASE
PKS13

(Mycobacterium
tuberculosis) 		PF00698
(Acyl_transf_1) 		4 ARG A 674
VAL A 676
LEU A 678
ALA A 628
 None
 0.60A 5jq7A-3tzwA:
undetectable		 5jq7A-3tzwA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v7i PUTATIVE POLYKETIDE
SYNTHASE

(Streptomyces
coelicolor) 		PF00195
(Chal_sti_synt_N) 		4 VAL A 200
ALA A 231
LEU A 155
LEU A 159
 None
 0.67A 5jq7A-3v7iA:
undetectable		 5jq7A-3v7iA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vzg ZYMOGEN GRANULE
MEMBRANE PROTEIN 16

(Homo sapiens) 		PF01419
(Jacalin) 		5 VAL A  97
LEU A 139
ALA A 130
LEU A 108
LEU A 105
 None
 0.88A 5jq7A-3vzgA:
undetectable		 5jq7A-3vzgA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wnp CYCLOISOMALTOOLIGOSA
CCHARIDE
GLUCANOTRANSFERASE

(Bacillus
circulans) 		PF13199
(Glyco_hydro_66)
PF16990
(CBM_35) 		4 VAL A 307
ALA A 234
LEU A 351
LEU A 341
 None
 0.61A 5jq7A-3wnpA:
undetectable		 5jq7A-3wnpA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a4z ANTIVIRAL HELICASE
SKI2

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF08148
(DSHCT)
PF13234
(rRNA_proc-arch) 		4 VAL A1252
LEU A1264
GLU A1251
LEU A1150
 None
 0.63A 5jq7A-4a4zA:
undetectable		 5jq7A-4a4zA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b0n POLYKETIDE SYNTHASE
III

(Ectocarpus
siliculosus) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 VAL A 221
LEU A 223
LEU A 170
LEU A 174
 None
 0.67A 5jq7A-4b0nA:
undetectable		 5jq7A-4b0nA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b43 TRANSLATION
INITIATION FACTOR
IF-2

(Thermus
thermophilus) 		PF00009
(GTP_EFTU)
PF04760
(IF2_N) 		5 VAL A  46
LEU A  23
GLU A  44
ALA A  45
LEU A   9
 None
 1.33A 5jq7A-4b43A:
undetectable		 5jq7A-4b43A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bgb PUTATIVE SUGAR
KINASE MK0840

(Methanopyrus
kandleri) 		PF03702
(AnmK) 		4 VAL A 166
ALA A 170
LEU A 295
LEU A 293
 None
 0.59A 5jq7A-4bgbA:
undetectable		 5jq7A-4bgbA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4boo ACETYLCHOLINE
RECEPTOR DELTA
SUBUNIT

(Torpedo
marmorata) 		PF02931
(Neur_chan_LBD)
PF02932
(Neur_chan_memb) 		4 VAL C  56
ALA C 124
LEU C  37
LEU C  35
 None
 0.67A 5jq7A-4booC:
undetectable		 5jq7A-4booC:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4buj ANTIVIRAL HELICASE
SKI2

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF08148
(DSHCT) 		4 VAL A1252
LEU A1264
GLU A1251
LEU A1150
 None
 0.57A 5jq7A-4bujA:
undetectable		 5jq7A-4bujA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cxk ARYLSULFATASE

(Pseudomonas
aeruginosa) 		PF00884
(Sulfatase) 		4 VAL A 476
LEU A 478
ALA A 467
LEU A 492
 None
 0.65A 5jq7A-4cxkA:
undetectable		 5jq7A-4cxkA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4got METHIONINE-BINDING
LIPOPROTEIN METQ

(Bacillus
subtilis) 		PF03180
(Lipoprotein_9) 		4 VAL A  35
ALA A  82
LEU A  60
LEU A  53
 None
 0.67A 5jq7A-4gotA:
undetectable		 5jq7A-4gotA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hoz SUCROSE ISOMERASE

(Erwinia
rhapontici) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		4 VAL A 548
LEU A 588
ALA A 535
LEU A 598
 None
 0.68A 5jq7A-4hozA:
undetectable		 5jq7A-4hozA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n68 CONTACTIN-5

(Homo sapiens) 		PF00041
(fn3) 		4 VAL A 894
ALA A 884
LEU A 937
LEU A 940
 None
 0.65A 5jq7A-4n68A:
undetectable		 5jq7A-4n68A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nkh E3 UBIQUITIN-PROTEIN
LIGASE SSPH1

(Salmonella
enterica) 		no annotation 4 VAL A 284
LEU A 289
ALA A 264
LEU A 279
 None
 0.55A 5jq7A-4nkhA:
undetectable		 5jq7A-4nkhA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nkh E3 UBIQUITIN-PROTEIN
LIGASE SSPH1

(Salmonella
enterica) 		no annotation 4 VAL A 344
LEU A 349
ALA A 324
LEU A 339
 None
 0.59A 5jq7A-4nkhA:
undetectable		 5jq7A-4nkhA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o59 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Bos taurus) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 VAL O 305
LEU O 307
ALA O 299
LEU O 246
 None
 0.58A 5jq7A-4o59O:
undetectable		 5jq7A-4o59O:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ow2 YOP EFFECTOR YOPM

(Yersinia
enterocolitica) 		PF12468
(TTSSLRR) 		4 VAL A 118
LEU A 123
ALA A  98
LEU A 113
 None
 0.55A 5jq7A-4ow2A:
undetectable		 5jq7A-4ow2A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ow2 YOP EFFECTOR YOPM

(Yersinia
enterocolitica) 		PF12468
(TTSSLRR) 		4 VAL A 180
LEU A 185
ALA A 160
LEU A 175
 None
 0.58A 5jq7A-4ow2A:
undetectable		 5jq7A-4ow2A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ow2 YOP EFFECTOR YOPM

(Yersinia
enterocolitica) 		PF12468
(TTSSLRR) 		4 VAL A 300
LEU A 305
ALA A 280
LEU A 295
 None
 0.67A 5jq7A-4ow2A:
undetectable		 5jq7A-4ow2A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ow2 YOP EFFECTOR YOPM

(Yersinia
enterocolitica) 		PF12468
(TTSSLRR) 		4 VAL A 360
LEU A 365
ALA A 340
LEU A 355
 None
 0.66A 5jq7A-4ow2A:
undetectable		 5jq7A-4ow2A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ow2 YOP EFFECTOR YOPM

(Yersinia
enterocolitica) 		PF12468
(TTSSLRR) 		4 VAL A 420
LEU A 425
ALA A 400
LEU A 415
 None
 0.56A 5jq7A-4ow2A:
undetectable		 5jq7A-4ow2A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ow2 YOP EFFECTOR YOPM

(Yersinia
enterocolitica) 		PF12468
(TTSSLRR) 		4 VAL A 460
LEU A 465
ALA A 440
LEU A 455
 None
 0.64A 5jq7A-4ow2A:
undetectable		 5jq7A-4ow2A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4per RIBONUCLEASE
INHIBITOR

(Gallus gallus) 		PF13516
(LRR_6) 		4 VAL A 315
LEU A 320
LEU A 341
LEU A 338
 None
 0.68A 5jq7A-4perA:
undetectable		 5jq7A-4perA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4prk 4-PHOSPHOERYTHRONATE
DEHYDROGENASE

(Lactobacillus
jensenii) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 VAL A  48
LEU A  50
ALA A   4
LEU A  65
 None
 0.57A 5jq7A-4prkA:
undetectable		 5jq7A-4prkA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r85 CYTOSINE DEAMINASE

(Klebsiella
pneumoniae) 		PF07969
(Amidohydro_3) 		5 VAL A 384
LEU A 326
GLU A 382
ALA A 383
LEU A 341
 None
 1.41A 5jq7A-4r85A:
undetectable		 5jq7A-4r85A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN

(Nitratireductor
pacificus) 		PF12838
(Fer4_7)
PF13486
(Dehalogenase) 		4 ARG A 351
LEU A 496
GLU A 354
ALA A 355
 None
 0.67A 5jq7A-4rasA:
undetectable		 5jq7A-4rasA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u28 PHOSPHORIBOSYL
ISOMERASE A

(Streptomyces
sviceus) 		PF00977
(His_biosynth) 		4 VAL A  16
ALA A  21
LEU A  55
LEU A  53
 None
 0.66A 5jq7A-4u28A:
undetectable		 5jq7A-4u28A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v1a MITORIBOSOMAL
PROTEIN ML48, MRPL48

(Sus scrofa) 		no annotation 4 VAL k 186
LEU k 184
GLU k 188
LEU k 162
 None
 0.68A 5jq7A-4v1ak:
undetectable		 5jq7A-4v1ak:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yok PUTATIVE FLAGELLAR
PROTEIN FLIS

(Parabacteroides
merdae) 		PF12866
(DUF3823) 		4 VAL A  73
LEU A  47
LEU A  56
LEU A  90
 None
 0.67A 5jq7A-4yokA:
undetectable		 5jq7A-4yokA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z0h GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
GAPC1, CYTOSOLIC

(Arabidopsis
thaliana) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 VAL O 305
LEU O 307
ALA O 299
LEU O 246
 None
 0.51A 5jq7A-4z0hO:
undetectable		 5jq7A-4z0hO:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a3f DYNAMIN 3

(Homo sapiens) 		PF00169
(PH)
PF00350
(Dynamin_N)
PF01031
(Dynamin_M)
PF02212
(GED) 		4 VAL A 124
ALA A  81
LEU A  71
LEU A  69
 None
 0.57A 5jq7A-5a3fA:
undetectable		 5jq7A-5a3fA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c7i GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
TESTIS-SPECIFIC

(Mus musculus) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 VAL O 412
LEU O 414
ALA O 406
LEU O 353
 None
 0.56A 5jq7A-5c7iO:
undetectable		 5jq7A-5c7iO:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c7o GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
TESTIS-SPECIFIC

(Homo sapiens) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 VAL O 380
LEU O 382
ALA O 374
LEU O 321
 None
 0.59A 5jq7A-5c7oO:
undetectable		 5jq7A-5c7oO:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d3q DYNAMIN-1,DYNAMIN-1

(Homo sapiens) 		PF00350
(Dynamin_N)
PF01031
(Dynamin_M) 		4 VAL A 124
ALA A  81
LEU A  71
LEU A  69
 None
 0.50A 5jq7A-5d3qA:
undetectable		 5jq7A-5d3qA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eio N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE/N-ACET
YL-GAMMA-AMINOADIPYL
-PHOSPHATE REDUCTASE

(Thermus
thermophilus) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		4 VAL A 173
LEU A 175
ALA A 240
LEU A 217
 None
 0.54A 5jq7A-5eioA:
undetectable		 5jq7A-5eioA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5erb POLYKETIDE SYNTHASE

(Bacillus
amyloliquefaciens) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 VAL A 128
GLU A 203
ALA A 204
LEU A 116
 None
 0.59A 5jq7A-5erbA:
undetectable		 5jq7A-5erbA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ere EXTRACELLULAR
LIGAND-BINDING
RECEPTOR

(Desulfohalobium
retbaense) 		PF13458
(Peripla_BP_6) 		5 VAL A 378
LEU A 402
ALA A 379
LEU A 469
LEU A 581
 None
 1.36A 5jq7A-5ereA:
undetectable		 5jq7A-5ereA:
22.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f1b GP1

(Zaire
ebolavirus) 		PF01611
(Filo_glycop) 		6 VAL A  66
LEU A  68
GLU A 100
ALA A 101
LEU A 184
LEU A 186
 None
 0.44A 5jq7A-5f1bA:
19.2		 5jq7A-5f1bA:
99.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f56 SINGLE-STRANDED-DNA-
SPECIFIC EXONUCLEASE

(Deinococcus
radiodurans) 		PF01368
(DHH)
PF02272
(DHHA1) 		4 ARG A  15
GLU A 605
LEU A  18
LEU A  19
 None
 0.67A 5jq7A-5f56A:
undetectable		 5jq7A-5f56A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ggg PROTEIN
O-LINKED-MANNOSE
BETA-1,2-N-ACETYLGLU
COSAMINYLTRANSFERASE
1

(Homo sapiens) 		PF03071
(GNT-I)
PF15711
(ILEI) 		4 ARG A 616
VAL A 623
ALA A 577
LEU A 597
 None
 0.59A 5jq7A-5gggA:
undetectable		 5jq7A-5gggA:
20.65