SIMILAR PATTERNS OF AMINO ACIDS FOR 5JO9_A_SORA302

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1au8 CATHEPSIN G

(Homo sapiens) 		PF00089
(Trypsin) 		5 GLY A 197
PRO A 198
VAL A 138
PHE A  45
LEU A  53
 None
 1.19A 5jo9A-1au8A:
undetectable		 5jo9A-1au8A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1euf DUODENASE

(Bos taurus) 		PF00089
(Trypsin) 		5 GLY A 197
PRO A 198
VAL A 138
PHE A  45
LEU A  53
 None
 1.15A 5jo9A-1eufA:
undetectable		 5jo9A-1eufA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f8f BENZYL ALCOHOL
DEHYDROGENASE

(Acinetobacter
calcoaceticus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 SER A  68
LEU A 168
GLY A 169
PRO A 170
LEU A 167
 None
 1.46A 5jo9A-1f8fA:
8.7		 5jo9A-1f8fA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fq3 GRANZYME B

(Homo sapiens) 		PF00089
(Trypsin) 		5 GLY A 197
PRO A 198
VAL A 138
PHE A  45
LEU A  53
 None
 1.28A 5jo9A-1fq3A:
undetectable		 5jo9A-1fq3A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hno D3,D2-ENOYL COA
ISOMERASE ECI1

(Saccharomyces
cerevisiae) 		PF00378
(ECH_1) 		5 SER A 203
GLY A 121
PRO A 122
VAL A 144
PHE A  65
 EDO  A 282 (-3.0A)
None
None
None
None
 1.29A 5jo9A-1hnoA:
undetectable		 5jo9A-1hnoA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m3a PROTO-ONCOGENE C-CRK

(Mus musculus) 		PF00018
(SH3_1) 		5 LEU A 159
PRO A 183
VAL A 184
TRP A 169
PHE A 153
 None
 1.33A 5jo9A-1m3aA:
undetectable		 5jo9A-1m3aA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n5x XANTHINE
DEHYDROGENASE

(Bos taurus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		5 LEU A  34
THR A  87
GLU A  89
GLY A  35
LEU A  30
 None
 1.32A 5jo9A-1n5xA:
undetectable		 5jo9A-1n5xA:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nun FIBROBLAST GROWTH
FACTOR RECEPTOR 2
ISOFORM 2

(Homo sapiens) 		PF07679
(I-set) 		5 LEU B 327
THR B 268
VAL B 324
PHE B 276
LEU B 355
 None
 1.22A 5jo9A-1nunB:
undetectable		 5jo9A-1nunB:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vb3 THREONINE SYNTHASE

(Escherichia
coli) 		PF00291
(PALP)
PF14821
(Thr_synth_N) 		5 LEU A 372
THR A 237
GLY A  94
VAL A  89
LEU A 233
 None
 1.24A 5jo9A-1vb3A:
3.4		 5jo9A-1vb3A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wz9 MASPIN PRECURSOR

(Homo sapiens) 		PF00079
(Serpin) 		5 SER A  36
LEU A  35
PRO A  32
PHE A  30
LEU A  15
 None
 1.38A 5jo9A-1wz9A:
undetectable		 5jo9A-1wz9A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y7o ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT

(Streptococcus
pneumoniae) 		PF00574
(CLP_protease) 		5 SER A  70
LEU A  73
THR A 146
GLY A  72
VAL A  34
 None
 1.39A 5jo9A-1y7oA:
undetectable		 5jo9A-1y7oA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y9u PUTATIVE IRON
BINDING PROTEIN

(Bordetella
pertussis) 		PF13343
(SBP_bac_6) 		5 SER A 103
LEU A 102
GLY A 241
VAL A  62
LEU A 261
 None
 1.37A 5jo9A-1y9uA:
undetectable		 5jo9A-1y9uA:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2asu HEPATOCYTE GROWTH
FACTOR-LIKE PROTEIN

(Homo sapiens) 		PF00089
(Trypsin) 		5 TYR B 594
LEU B 665
THR B 600
GLY B 677
VAL B 697
 None
 1.17A 5jo9A-2asuB:
undetectable		 5jo9A-2asuB:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2de2 DIBENZOTHIOPHENE
DESULFURIZATION
ENZYME B

(Rhodococcus sp.
IGTS8) 		no annotation 5 SER A 253
LEU A  97
PRO A  30
PHE A 309
LEU A 226
 None
GOL  A 503 (-4.5A)
GOL  A 503 ( 4.9A)
None
None
 1.28A 5jo9A-2de2A:
undetectable		 5jo9A-2de2A:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e7u GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE

(Thermus
thermophilus) 		PF00202
(Aminotran_3) 		5 TYR A 105
LEU A 255
THR A 242
GLU A 239
GLY A 256
 None
 1.31A 5jo9A-2e7uA:
undetectable		 5jo9A-2e7uA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fli RIBULOSE-PHOSPHATE
3-EPIMERASE

(Streptococcus
pyogenes) 		PF00834
(Ribul_P_3_epim) 		5 SER A  47
GLY A  49
VAL A  52
PHE A  80
LEU A  68
 None
 1.36A 5jo9A-2fliA:
undetectable		 5jo9A-2fliA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gwn DIHYDROOROTASE

(Porphyromonas
gingivalis) 		PF01979
(Amidohydro_1) 		5 LEU A 177
GLY A 147
PRO A 146
VAL A 145
PHE A 369
 None
 1.39A 5jo9A-2gwnA:
undetectable		 5jo9A-2gwnA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gzb KUNITZ-TYPE
PROTEINASE INHIBITOR
BBCI

(Bauhinia
bauhinioides) 		PF00197
(Kunitz_legume) 		5 SER A 106
THR A 102
GLY A 109
PRO A 110
PHE A 111
 None
 0.89A 5jo9A-2gzbA:
undetectable		 5jo9A-2gzbA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jjv SIGNAL-REGULATORY
PROTEIN BETA 1.

(Homo sapiens) 		PF07686
(V-set) 		5 SER A  29
LEU A   4
PRO A  32
VAL A  33
PHE A 104
 None
 1.18A 5jo9A-2jjvA:
undetectable		 5jo9A-2jjvA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2obn HYPOTHETICAL PROTEIN

(Trichormus
variabilis) 		PF07755
(DUF1611)
PF17396
(DUF1611_N) 		5 LEU A 155
THR A 188
GLU A 231
VAL A 259
LEU A 247
 None
 1.41A 5jo9A-2obnA:
4.6		 5jo9A-2obnA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogs THERMOSTABLE
CARBOXYLESTERASE
EST50

(Geobacillus
stearothermophilus) 		PF00135
(COesterase) 		5 TYR A 138
LEU A 226
GLY A 276
PRO A 277
LEU A 225
 TYR  A 138 ( 1.3A)
LEU  A 226 ( 0.6A)
GLY  A 276 ( 0.0A)
PRO  A 277 ( 1.1A)
LEU  A 225 ( 0.6A)
 1.32A 5jo9A-2ogsA:
3.9		 5jo9A-2ogsA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pz8 NH(3)-DEPENDENT
NAD(+) SYNTHETASE

(Bacillus
anthracis) 		PF02540
(NAD_synthase) 		5 LEU A 179
THR A  37
VAL A  27
PHE A  42
LEU A 154
 None
 1.47A 5jo9A-2pz8A:
2.1		 5jo9A-2pz8A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qb0 TELSAM DOMAIN -
LYSOZYME CHIMERA

(Escherichia
virus T4) 		PF00959
(Phage_lysozyme)
PF02198
(SAM_PNT) 		5 THR B  54
GLY B  78
VAL B  80
TRP B  37
PHE B  70
 None
 1.34A 5jo9A-2qb0B:
undetectable		 5jo9A-2qb0B:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uur COLLAGEN ALPHA-1(IX)
CHAIN

(Homo sapiens) 		no annotation 5 LEU A 197
THR A  92
GLY A 198
PHE A 210
LEU A 212
 None
 1.42A 5jo9A-2uurA:
undetectable		 5jo9A-2uurA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uur COLLAGEN ALPHA-1(IX)
CHAIN

(Homo sapiens) 		no annotation 5 LEU A 197
THR A  92
GLY A 198
VAL A 208
LEU A 212
 None
 1.42A 5jo9A-2uurA:
undetectable		 5jo9A-2uurA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vf8 EXCINUCLEASE ABC
SUBUNIT A

(Deinococcus
radiodurans) 		PF00005
(ABC_tran) 		5 SER A 534
THR A 538
GLY A 806
VAL A 817
LEU A 513
 ADP  A1844 (-3.9A)
ADP  A1844 (-3.2A)
None
None
None
 1.40A 5jo9A-2vf8A:
undetectable		 5jo9A-2vf8A:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wng TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE
SUBSTRATE 1

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 SER A  29
LEU A   4
PRO A  32
VAL A  33
PHE A 103
 None
 1.20A 5jo9A-2wngA:
undetectable		 5jo9A-2wngA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xry DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE

(Methanosarcina
mazei) 		PF00875
(DNA_photolyase) 		5 SER A  40
TRP A  24
VAL A 141
PHE A 138
LEU A 113
 None
 1.46A 5jo9A-2xryA:
2.5		 5jo9A-2xryA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y4o PHENYLACETATE-COENZY
ME A LIGASE

(Burkholderia
cenocepacia) 		PF00501
(AMP-binding)
PF14535
(AMP-binding_C_2) 		5 TYR A 305
THR A 105
GLU A 245
GLY A 248
VAL A 251
 None
None
DLL  A1441 ( 4.6A)
DLL  A1441 ( 4.4A)
None
 1.45A 5jo9A-2y4oA:
5.5		 5jo9A-2y4oA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yjq CEL44C

(Paenibacillus
polymyxa) 		PF12891
(Glyco_hydro_44) 		5 SER A 212
GLY A 230
PRO A 231
VAL A 232
PHE A 281
 None
 1.15A 5jo9A-2yjqA:
undetectable		 5jo9A-2yjqA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aar ECTONUCLEOSIDE
TRIPHOSPHATE
DIPHOSPHOHYDROLASE I

(Legionella
pneumophila) 		PF01150
(GDA1_CD39) 		5 LEU A 165
GLY A 387
VAL A 389
PHE A 162
LEU A 161
 None
 1.38A 5jo9A-3aarA:
undetectable		 5jo9A-3aarA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c5w PP2A-SPECIFIC
METHYLESTERASE PME-1

(Homo sapiens) 		PF12697
(Abhydrolase_6) 		5 SER P  88
LEU P  90
GLU P 353
GLY P 233
VAL P 235
 None
 1.44A 5jo9A-3c5wP:
4.7		 5jo9A-3c5wP:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3chx PMOB
PMOA

(Methylosinus
trichosporium;
Methylosinus
trichosporium) 		PF04744
(Monooxygenase_B)
PF02461
(AMO) 		5 THR B 196
GLY A 102
PRO A 103
VAL A 104
PHE B 119
 None
 1.08A 5jo9A-3chxB:
undetectable		 5jo9A-3chxB:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f7s UNCHARACTERIZED
NTF2-LIKE PROTEIN

(Pseudomonas
putida) 		PF13474
(SnoaL_3) 		5 TYR A  53
TRP A 124
GLU A 122
TRP A  57
PHE A  70
 None
UNL  A 142 ( 4.4A)
None
UNL  A 142 (-4.0A)
None
 1.16A 5jo9A-3f7sA:
undetectable		 5jo9A-3f7sA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g01 GRANZYME C

(Mus musculus) 		PF00089
(Trypsin) 		5 GLY A 206
PRO A 207
VAL A 145
PHE A  53
LEU A  61
 None
 1.14A 5jo9A-3g01A:
undetectable		 5jo9A-3g01A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gg9 D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
OXIDOREDUCTASE
PROTEIN

(Ralstonia
solanacearum) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 SER A 225
LEU A 228
TRP A 198
GLY A 173
VAL A 195
 None
 1.45A 5jo9A-3gg9A:
3.4		 5jo9A-3gg9A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hc1 UNCHARACTERIZED HDOD
DOMAIN PROTEIN

(Geobacter
sulfurreducens) 		PF08668
(HDOD) 		5 LEU A 149
GLU A  95
GLY A 148
VAL A 233
LEU A 123
 None
GOL  A 311 (-3.5A)
None
None
None
 1.32A 5jo9A-3hc1A:
undetectable		 5jo9A-3hc1A:
25.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3if2 AMINOTRANSFERASE

(Psychrobacter
arcticus) 		PF00155
(Aminotran_1_2) 		5 TYR A 157
LEU A 150
THR A 215
PRO A 149
LEU A 222
 None
 1.21A 5jo9A-3if2A:
undetectable		 5jo9A-3if2A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ip1 ALCOHOL
DEHYDROGENASE,
ZINC-CONTAINING

(Thermotoga
maritima) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 SER A 172
LEU A 173
VAL A 101
PHE A 186
LEU A 185
 None
 1.16A 5jo9A-3ip1A:
9.4		 5jo9A-3ip1A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ju8 SUCCINYLGLUTAMIC
SEMIALDEHYDE
DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF00171
(Aldedh) 		5 LEU A 252
THR A 266
GLY A 408
VAL A 429
LEU A 410
 None
 1.37A 5jo9A-3ju8A:
5.1		 5jo9A-3ju8A:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3krs TRIOSEPHOSPHATE
ISOMERASE

(Cryptosporidium
parvum) 		PF00121
(TIM) 		5 LEU A 232
GLY A   8
VAL A  37
PHE A  40
LEU A  94
 None
 1.27A 5jo9A-3krsA:
2.2		 5jo9A-3krsA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lmm UNCHARACTERIZED
PROTEIN

(Corynebacterium
diphtheriae) 		PF04326
(AlbA_2)
PF13749
(HATPase_c_4) 		5 SER A 225
LEU A 224
GLY A 228
PHE A 232
LEU A 212
 CL  A 585 ( 4.4A)
None
None
None
None
 1.40A 5jo9A-3lmmA:
undetectable		 5jo9A-3lmmA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nmz RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4

(Homo sapiens) 		no annotation 5 TYR D 175
THR D 207
GLU D 212
PRO D 244
TRP D 231
 None
 1.33A 5jo9A-3nmzD:
undetectable		 5jo9A-3nmzD:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ns4 VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 53

(Saccharomyces
cerevisiae) 		PF16854
(VPS53_C) 		5 LEU A 709
PRO A 600
VAL A 601
TRP A 714
PHE A 758
 None
 1.18A 5jo9A-3ns4A:
undetectable		 5jo9A-3ns4A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ns4 VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 53

(Saccharomyces
cerevisiae) 		PF16854
(VPS53_C) 		5 LEU A 709
TRP A 719
PRO A 600
VAL A 601
PHE A 758
 None
 1.26A 5jo9A-3ns4A:
undetectable		 5jo9A-3ns4A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3omb EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, FAMILY 1

(Bifidobacterium
longum) 		PF01547
(SBP_bac_1) 		5 SER A 256
THR A 489
GLY A 246
VAL A 242
PHE A 220
 None
 1.45A 5jo9A-3ombA:
undetectable		 5jo9A-3ombA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3otx ADENOSINE KINASE,
PUTATIVE

(Trypanosoma
brucei) 		PF00294
(PfkB) 		5 LEU A  66
GLU A 106
GLY A  62
PRO A  61
VAL A  60
 None
None
AP5  A 346 (-3.6A)
None
None
 1.25A 5jo9A-3otxA:
7.6		 5jo9A-3otxA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3usw FLAGELLAR MOTOR
SWITCH PROTEIN

(Helicobacter
pylori) 		PF01706
(FliG_C)
PF14841
(FliG_M) 		5 SER A 278
LEU A 275
VAL A 252
PHE A 286
LEU A 271
 None
 1.38A 5jo9A-3uswA:
undetectable		 5jo9A-3uswA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3usy FLAGELLAR MOTOR
SWITCH PROTEIN

(Helicobacter
pylori) 		PF01706
(FliG_C)
PF14841
(FliG_M) 		5 SER A 278
LEU A 275
VAL A 252
PHE A 286
LEU A 271
 None
 1.38A 5jo9A-3usyA:
undetectable		 5jo9A-3usyA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vk5 MOEO5

(Streptomyces
viridosporus) 		PF01884
(PcrB) 		5 GLY A  35
PRO A  36
VAL A 248
PHE A  62
LEU A  60
 None
 1.41A 5jo9A-3vk5A:
undetectable		 5jo9A-3vk5A:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vm5 ALPHA-AMYLASE

(Oryzias latipes) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C) 		5 LEU A 262
THR A 277
TRP A 284
GLY A 259
LEU A 265
 None
 1.41A 5jo9A-3vm5A:
undetectable		 5jo9A-3vm5A:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wst PROTEIN ARGININE
N-METHYLTRANSFERASE
7

(Caenorhabditis
elegans) 		PF13649
(Methyltransf_25) 		5 TYR A 607
SER A 390
LEU A 392
VAL A 361
PHE A 370
 None
 1.37A 5jo9A-3wstA:
4.5		 5jo9A-3wstA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wsu BETA-MANNANASE

(Streptomyces
thermolilacinus) 		PF00150
(Cellulase) 		5 SER A 325
LEU A 324
GLY A 328
PHE A 332
LEU A  94
 None
 1.38A 5jo9A-3wsuA:
undetectable		 5jo9A-3wsuA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a1o BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH

(Mycobacterium
tuberculosis) 		PF01808
(AICARFT_IMPCHas)
PF02142
(MGS) 		5 LEU A  82
THR A  73
GLY A  81
PHE A 103
LEU A  14
 None
JLN  A1528 (-2.7A)
None
None
None
 1.33A 5jo9A-4a1oA:
4.4		 5jo9A-4a1oA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ajt PROTEIN Z-DEPENDENT
PROTEASE INHIBITOR

(Mus musculus) 		PF00079
(Serpin) 		5 SER A  89
LEU A  88
PRO A  85
PHE A  83
LEU A  69
 None
 1.42A 5jo9A-4ajtA:
undetectable		 5jo9A-4ajtA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4azw WBDD

(Escherichia
coli) 		PF00069
(Pkinase)
PF13847
(Methyltransf_31) 		5 TYR A 230
LEU A 320
PRO A 354
VAL A 357
TRP A 355
 None
 1.44A 5jo9A-4azwA:
6.2		 5jo9A-4azwA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ce7 UNSATURATED
3S-RHAMNOGLYCURONYL
HYDROLASE

(Nonlabens
ulvanivorans) 		PF07470
(Glyco_hydro_88) 		5 THR A  52
GLY A 226
VAL A 224
PHE A 286
LEU A 353
 None
 1.02A 5jo9A-4ce7A:
undetectable		 5jo9A-4ce7A:
21.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4cr6 N-ACYLMANNOSAMINE
1-DEHYDROGENASE

(Flavobacterium
sp. 141-8) 		PF13561
(adh_short_C2) 		5 SER A 153
GLU A 160
GLY A 197
PRO A 198
VAL A 199
 None
 0.80A 5jo9A-4cr6A:
26.9		 5jo9A-4cr6A:
30.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fln PROTEASE DO-LIKE 2,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		5 GLY A 270
PRO A 271
VAL A 222
PHE A 147
LEU A 155
 None
 1.20A 5jo9A-4flnA:
undetectable		 5jo9A-4flnA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hdt 3-HYDROXYISOBUTYRYL-
COA HYDROLASE

(Mycolicibacterium
thermoresistibile) 		PF16113
(ECH_2) 		5 SER A  29
LEU A  30
GLY A  68
VAL A  70
PHE A  87
 None
None
None
None
ACT  A 406 (-3.7A)
 1.36A 5jo9A-4hdtA:
undetectable		 5jo9A-4hdtA:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hmw PYRIDOXAMINE
5'-PHOSPHATE OXIDASE

(Burkholderia
lata) 		PF01243
(Putative_PNPOx)
PF10590
(PNP_phzG_C) 		5 SER A  83
THR A  53
VAL A 173
PHE A  77
LEU A  51
 FMN  A 301 (-3.4A)
None
None
None
None
 1.15A 5jo9A-4hmwA:
undetectable		 5jo9A-4hmwA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ijn ACETATE KINASE

(Mycolicibacterium
smegmatis) 		PF00871
(Acetate_kinase) 		5 LEU A 190
GLY A 313
VAL A 316
PHE A 308
LEU A 188
 None
None
AMP  A 402 (-4.6A)
None
None
 1.37A 5jo9A-4ijnA:
2.0		 5jo9A-4ijnA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4imp POLYKETIDE SYNTHASE
EXTENDER MODULES 3-4

(Saccharopolyspora
spinosa) 		PF08659
(KR) 		5 SER A 145
LEU A 146
PRO A  90
VAL A 118
LEU A 149
 None
 1.35A 5jo9A-4impA:
20.9		 5jo9A-4impA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j8l UNCHARACTERIZED
PROTEIN YHFS

(Escherichia
coli) 		PF00155
(Aminotran_1_2) 		5 LEU A  83
THR A 104
GLY A  82
VAL A 206
LEU A 139
 None
 1.32A 5jo9A-4j8lA:
undetectable		 5jo9A-4j8lA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k08 METHYL-ACCEPTING
CHEMOTAXIS SENSORY
TRANSDUCER

(Anaeromyxobacter
dehalogenans) 		PF17200
(sCache_2) 		5 TYR A  94
TRP A 149
VAL A  97
PHE A 130
LEU A 129
 ACT  A 201 (-4.4A)
ACT  A 201 (-3.3A)
None
ACT  A 201 ( 4.8A)
None
 1.23A 5jo9A-4k08A:
undetectable		 5jo9A-4k08A:
28.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kr5 GLUTAMINE ABC
TRANSPORTER PERMEASE
AND SUBSTRATE
BINDING PROTEIN
PROTEIN

(Lactococcus
lactis) 		PF00497
(SBP_bac_3) 		5 LEU A 414
THR A 352
GLY A 371
VAL A 393
LEU A 406
 None
 0.99A 5jo9A-4kr5A:
undetectable		 5jo9A-4kr5A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ote LIPOPROTEIN

(Clostridioides
difficile) 		PF03180
(Lipoprotein_9) 		5 TYR A  66
LEU A  82
GLY A  40
PRO A  39
VAL A  38
 None
 1.44A 5jo9A-4oteA:
undetectable		 5jo9A-4oteA:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ueg GLYCOGENIN-2

(Homo sapiens) 		PF01501
(Glyco_transf_8) 		5 SER A  27
LEU A  24
GLY A  25
VAL A  56
LEU A 103
 None
 1.38A 5jo9A-4uegA:
3.0		 5jo9A-4uegA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xdo LYSINE-SPECIFIC
DEMETHYLASE 4C

(Homo sapiens) 		PF02373
(JmjC)
PF02375
(JmjN) 		5 TYR A 211
THR A 186
GLY A  82
VAL A 251
LEU A 127
 None
 1.46A 5jo9A-4xdoA:
undetectable		 5jo9A-4xdoA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ydo UNCHARACTERIZED
PROTEIN

(Candida
albicans) 		PF00432
(Prenyltrans) 		5 SER B 410
TRP B 403
GLY B 358
PHE B 359
LEU B 376
 None
 1.35A 5jo9A-4ydoB:
undetectable		 5jo9A-4ydoB:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysw XANTHINE
DEHYDROGENASE/OXIDAS
E

(Rattus
norvegicus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		5 LEU A  34
THR A  87
GLU A  89
GLY A  35
LEU A  30
 None
 1.39A 5jo9A-4yswA:
undetectable		 5jo9A-4yswA:
11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z17 ENOLASE

(Chloroflexus
aurantiacus) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		5 SER A 116
LEU A 113
GLY A 114
VAL A  24
LEU A 339
 None
 1.46A 5jo9A-4z17A:
undetectable		 5jo9A-4z17A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zuz SIDC

(Legionella
pneumophila) 		no annotation 5 LEU A 628
GLU A 713
GLY A 627
VAL A  51
LEU A 660
 None
 1.33A 5jo9A-4zuzA:
undetectable		 5jo9A-4zuzA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8d CARBOHYDRATE BINDING
FAMILY 6

(Ruminiclostridium
thermocellum) 		PF04616
(Glyco_hydro_43) 		5 LEU A 144
THR A 201
GLY A 146
PRO A 147
LEU A 148
 None
 1.44A 5jo9A-5a8dA:
undetectable		 5jo9A-5a8dA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d95 AMINOTRANSFERASE
CLASS-III

(Sphaerobacter
thermophilus) 		PF00202
(Aminotran_3) 		5 SER A 259
LEU A 260
THR A 278
GLY A 266
VAL A 270
 None
 1.06A 5jo9A-5d95A:
undetectable		 5jo9A-5d95A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dds CRMG

(Actinoalloteichus
sp. WH1-2216-6) 		PF00202
(Aminotran_3) 		5 LEU A 333
THR A 431
PRO A 283
VAL A 281
LEU A 332
 None
 1.41A 5jo9A-5ddsA:
2.4		 5jo9A-5ddsA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fo1 RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBF

(Corynebacterium
ammoniagenes) 		PF01687
(Flavokinase)
PF06574
(FAD_syn) 		5 TYR A 188
THR A  73
GLU A  76
GLY A 191
VAL A 283
 None
SO4  A1340 (-4.1A)
None
None
None
 1.42A 5jo9A-5fo1A:
2.8		 5jo9A-5fo1A:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ila PROTEASE DO-LIKE 9

(Arabidopsis
thaliana) 		PF13365
(Trypsin_2) 		5 GLY A 280
PRO A 281
VAL A 232
PHE A 157
LEU A 165
 None
 1.32A 5jo9A-5ilaA:
undetectable		 5jo9A-5ilaA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ilb PROTEASE DO-LIKE 2,
CHLOROPLASTIC,PROTEA
SE DO-LIKE 9

(Arabidopsis
thaliana) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		5 GLY A 270
PRO A 271
VAL A 222
PHE A 147
LEU A 155
 None
 1.23A 5jo9A-5ilbA:
undetectable		 5jo9A-5ilbA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iz4 PUTATIVE SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE

(Paraburkholderia
xenovorans) 		PF13561
(adh_short_C2) 		5 SER A 152
LEU A 153
THR A 159
GLY A 195
VAL A 197
 None
 0.94A 5jo9A-5iz4A:
26.4		 5jo9A-5iz4A:
27.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j4a TRNA NUCLEASE CDIA
IMMUNITY PROTEIN
CDII

(Burkholderia
pseudomallei;
Burkholderia
pseudomallei) 		no annotation
no annotation 		5 SER B  52
THR A 247
GLU A 204
GLY B   3
VAL B  15
 None
 1.17A 5jo9A-5j4aB:
undetectable		 5jo9A-5j4aB:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jiu RAN-BINDING PROTEIN
9

(Homo sapiens) 		PF00622
(SPRY) 		5 SER A 235
LEU A 234
PRO A 314
TRP A 169
PHE A 217
 None
 1.40A 5jo9A-5jiuA:
undetectable		 5jo9A-5jiuA:
20.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jo9 RIBITOL
2-DEHYDROGENASE

(Bradyrhizobium
japonicum) 		PF00106
(adh_short) 		12 TYR A  92
SER A 140
LEU A 141
THR A 147
TRP A 149
GLU A 150
GLY A 184
PRO A 185
VAL A 186
TRP A 194
PHE A 240
LEU A 242
 SOR  A 302 (-4.3A)
SOR  A 302 (-2.5A)
SOR  A 302 ( 3.8A)
SOR  A 302 (-3.8A)
SOR  A 302 ( 4.9A)
SOR  A 302 (-2.4A)
SOR  A 302 (-3.4A)
SOR  A 302 ( 2.8A)
SOR  A 302 ( 4.3A)
SOR  A 302 (-3.7A)
SOR  A 302 ( 4.7A)
SOR  A 302 ( 4.5A)
 0.12A 5jo9A-5jo9A:
45.7		 5jo9A-5jo9A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kdm MAJOR TEGUMENT
PROTEIN

(Human
gammaherpesvirus
4) 		PF12818
(Tegument_dsDNA) 		5 TYR D 388
LEU D 455
GLY D 456
PHE D 578
LEU D 551
 None
 1.29A 5jo9A-5kdmD:
undetectable		 5jo9A-5kdmD:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kdx METALLOPEPTIDASE

(Pseudomonas
aeruginosa) 		PF13402
(Peptidase_M60) 		5 SER A 505
LEU A 481
GLY A 480
VAL A 529
LEU A 518
 EDO  A1011 ( 3.6A)
EDO  A1009 ( 3.5A)
EDO  A1011 (-3.2A)
EDO  A1016 ( 4.9A)
None
 1.30A 5jo9A-5kdxA:
undetectable		 5jo9A-5kdxA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kva CAFFEOYL-COA
O-METHYLTRANSFERASE

(Sorghum bicolor) 		PF01596
(Methyltransf_3) 		5 LEU A 256
GLY A 201
VAL A 176
PHE A 173
LEU A  88
 None
 1.41A 5jo9A-5kvaA:
8.2		 5jo9A-5kvaA:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mmj 30S RIBOSOMAL
PROTEIN 3,
CHLOROPLASTIC

(Spinacia
oleracea) 		no annotation 5 SER w 127
LEU w 114
TRP w 150
VAL w 143
LEU w  99
 None
 1.43A 5jo9A-5mmjw:
undetectable		 5jo9A-5mmjw:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5viy BG1 FAB LIGHT CHAIN
BG1 FAB HEAVY CHAIN

(Homo sapiens;
Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set)
PF07654
(C1-set)
PF07686
(V-set) 		5 LEU H 144
THR G 178
GLY H 159
VAL H 202
LEU H 161
 None
 1.24A 5jo9A-5viyH:
undetectable		 5jo9A-5viyH:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xb7 BETA-GALACTOSIDASE

(Bifidobacterium
animalis) 		no annotation 5 SER A 497
LEU A 470
PRO A 468
VAL A 432
LEU A 403
 None
 0.98A 5jo9A-5xb7A:
2.6		 5jo9A-5xb7A:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xhq APOLIPOPROTEIN
N-ACYLTRANSFERASE

(Escherichia
coli) 		PF00795
(CN_hydrolase) 		5 LEU A 288
THR A 253
TRP A 265
GLY A 320
LEU A 284
 None
 1.16A 5jo9A-5xhqA:
undetectable		 5jo9A-5xhqA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xhq APOLIPOPROTEIN
N-ACYLTRANSFERASE

(Escherichia
coli) 		PF00795
(CN_hydrolase) 		5 SER A 293
LEU A 288
THR A 253
TRP A 265
LEU A 284
 None
 1.41A 5jo9A-5xhqA:
undetectable		 5jo9A-5xhqA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyi RIBOSOMAL PROTEIN
S14

(Trichomonas
vaginalis) 		PF00411
(Ribosomal_S11) 		5 THR O  60
GLY O  26
PRO O  27
VAL O  28
LEU O  96
 None
 1.05A 5jo9A-5xyiO:
undetectable		 5jo9A-5xyiO:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y09 PROTEASE DO-LIKE 9

(Arabidopsis
thaliana) 		no annotation 5 GLY A 280
PRO A 281
VAL A 232
PHE A 157
LEU A 165
 None
 1.34A 5jo9A-5y09A:
undetectable		 5jo9A-5y09A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yd0 SCHLAFEN 8

(Rattus
norvegicus) 		no annotation 5 SER A 126
THR A 147
PRO A 325
PHE A 321
LEU A 131
 None
 1.37A 5jo9A-5yd0A:
undetectable		 5jo9A-5yd0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yjh PERIOSTIN

(Homo sapiens) 		no annotation 5 SER A 612
LEU A 602
GLY A 574
PHE A 577
LEU A 595
 MG  A 727 (-2.8A)
MG  A 727 (-3.8A)
MG  A 727 (-3.5A)
None
None
 1.42A 5jo9A-5yjhA:
undetectable		 5jo9A-5yjhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yjp HUMAN CHYMASE

(Homo sapiens) 		no annotation 5 GLY A 197
PRO A 198
VAL A 138
PHE A  45
LEU A  53
 None
 0.95A 5jo9A-5yjpA:
undetectable		 5jo9A-5yjpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ys3 SUCCINATE-ACETATE
PERMEASE

(Citrobacter
koseri) 		no annotation 5 TYR A  72
LEU A 103
GLY A 104
VAL A 108
LEU A 138
 ACT  A 203 (-4.0A)
ACT  A 201 ( 4.9A)
78M  A 211 ( 4.0A)
78M  A 211 (-4.5A)
ACT  A 201 (-4.1A)
 1.39A 5jo9A-5ys3A:
undetectable		 5jo9A-5ys3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6byi BETA-MANNOSIDASE

(Xanthomonas
citri) 		no annotation 5 TYR A 415
THR A 452
GLU A 455
GLY A 474
LEU A 510
 None
 1.40A 5jo9A-6byiA:
undetectable		 5jo9A-6byiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6byx SHORT ULVAN LYASE

(Alteromonas sp.
LOR) 		no annotation 5 TYR A 476
LEU A 455
GLY A 458
PHE A 484
LEU A 500
 None
 1.30A 5jo9A-6byxA:
undetectable		 5jo9A-6byxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fm7 BETA-LACTAMASE

(Aeromonas
enteropelogenes) 		no annotation 5 LEU A  71
THR A 175
GLY A  72
VAL A  76
LEU A 171
 None
 1.36A 5jo9A-6fm7A:
undetectable		 5jo9A-6fm7A:
undetectable