SIMILAR PATTERNS OF AMINO ACIDS FOR 5JNC_D_ACTD305_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b4e PROTEIN
(5-AMINOLEVULINIC
ACID DEHYDRATASE)


(Escherichia
coli)
PF00490
(ALAD)
4 ALA A 269
ALA A 249
ILE A 301
LEU A 298
None
0.72A 5jncD-1b4eA:
0.0
5jncD-1b4eA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cjx 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE


(Pseudomonas
fluorescens)
PF00903
(Glyoxalase)
PF14696
(Glyoxalase_5)
4 ALA A  99
ALA A  94
ILE A 116
LEU A 124
None
0.82A 5jncD-1cjxA:
0.0
5jncD-1cjxA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e3e ALCOHOL
DEHYDROGENASE, CLASS
II


(Mus musculus)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
4 ALA A 241
ALA A 225
ILE A 212
LEU A 209
None
0.60A 5jncD-1e3eA:
0.0
5jncD-1e3eA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eu8 TREHALOSE/MALTOSE
BINDING PROTEIN


(Thermococcus
litoralis)
PF01547
(SBP_bac_1)
4 PRO A 391
ALA A 394
ALA A 384
ILE A 389
None
0.74A 5jncD-1eu8A:
0.0
5jncD-1eu8A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mxs KDPG ALDOLASE

(Pseudomonas
putida)
PF01081
(Aldolase)
4 ALA A 100
ALA A  83
ILE A  69
LEU A  66
None
0.53A 5jncD-1mxsA:
0.0
5jncD-1mxsA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nij HYPOTHETICAL PROTEIN
YJIA


(Escherichia
coli)
PF02492
(cobW)
PF07683
(CobW_C)
4 ALA A 180
ALA A 152
ILE A 155
LEU A 156
None
0.81A 5jncD-1nijA:
0.0
5jncD-1nijA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1otk PHENYLACETIC ACID
DEGRADATION PROTEIN
PAAC


(Escherichia
coli)
PF05138
(PaaA_PaaC)
4 ALA A  96
ALA A 159
ILE A 160
LEU A 209
None
0.80A 5jncD-1otkA:
undetectable
5jncD-1otkA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ox4 IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE
HISHF


(Saccharomyces
cerevisiae)
PF00117
(GATase)
PF00977
(His_biosynth)
4 ALA B 517
ALA B 498
ILE B 485
LEU B 482
None
0.47A 5jncD-1ox4B:
0.0
5jncD-1ox4B:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r9j TRANSKETOLASE

(Leishmania
mexicana)
PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C)
5 PRO A  35
ALA A  38
ALA A   8
ILE A  11
LEU A  70
None
1.19A 5jncD-1r9jA:
0.0
5jncD-1r9jA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sum PHOSPHATE TRANSPORT
SYSTEM PROTEIN PHOU
HOMOLOG 2


(Thermotoga
maritima)
PF01895
(PhoU)
4 PRO B 120
ALA B 123
ILE B  31
LEU B  34
None
0.79A 5jncD-1sumB:
undetectable
5jncD-1sumB:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1svc PROTEIN (NUCLEAR
FACTOR KAPPA-B
(NF-KB))


(Homo sapiens)
PF00554
(RHD_DNA_bind)
PF16179
(RHD_dimer)
4 ALA P 128
ALA P  94
ILE P  87
LEU P  45
None
0.82A 5jncD-1svcP:
undetectable
5jncD-1svcP:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t1e KUMAMOLISIN

(Bacillus sp.
MN-32)
PF00082
(Peptidase_S8)
PF09286
(Pro-kuma_activ)
4 PRO A 471
ALA A 474
ALA A 275
ILE A 217
None
0.82A 5jncD-1t1eA:
undetectable
5jncD-1t1eA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u3t ALCOHOL
DEHYDROGENASE ALPHA
CHAIN


(Homo sapiens)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
4 ALA A 237
ALA A 221
ILE A 208
LEU A 205
None
0.57A 5jncD-1u3tA:
undetectable
5jncD-1u3tA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u7w COENZYME A
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
COABC


(Escherichia
coli)
PF04127
(DFP)
4 ALA A 338
ALA A 328
ILE A 350
LEU A 347
None
CTP  A 500 ( 4.0A)
None
None
0.78A 5jncD-1u7wA:
undetectable
5jncD-1u7wA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uc4 DIOL DEHYDRASE ALPHA
SUBUNIT


(Klebsiella
oxytoca)
PF02286
(Dehydratase_LU)
4 PRO A 110
ALA A 281
ILE A 322
LEU A 326
None
0.76A 5jncD-1uc4A:
undetectable
5jncD-1uc4A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w85 PYRUVATE
DEHYDROGENASE E1
COMPONENT, ALPHA
SUBUNIT


(Geobacillus
stearothermophilus)
PF00676
(E1_dh)
5 PRO A  39
ALA A  37
ALA A 243
ILE A  25
LEU A  26
None
1.24A 5jncD-1w85A:
undetectable
5jncD-1w85A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wl4 ACETYL-COENZYME A
ACETYLTRANSFERASE 2


(Homo sapiens)
PF00108
(Thiolase_N)
PF02803
(Thiolase_C)
5 PRO A 297
ALA A 381
ALA A 300
ILE A 301
LEU A 335
None
1.47A 5jncD-1wl4A:
undetectable
5jncD-1wl4A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b2n TRANSCRIPTION-REPAIR
COUPLING FACTOR


(Escherichia
coli)
no annotation 4 PRO A 109
ALA A  46
ALA A  52
LEU A 106
None
0.74A 5jncD-2b2nA:
undetectable
5jncD-2b2nA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bru NAD(P)
TRANSHYDROGENASE
SUBUNIT ALPHA


(Escherichia
coli)
PF01262
(AlaDh_PNT_C)
PF05222
(AlaDh_PNT_N)
4 ALA A1209
ALA A1193
ILE A1181
LEU A1178
None
0.79A 5jncD-2bruA:
undetectable
5jncD-2bruA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c2g THREONINE SYNTHASE

(Arabidopsis
thaliana)
PF00291
(PALP)
4 PRO A 293
ALA A 325
ALA A 408
ILE A 291
None
0.82A 5jncD-2c2gA:
undetectable
5jncD-2c2gA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2du9 PREDICTED
TRANSCRIPTIONAL
REGULATORS


(Corynebacterium
glutamicum)
PF00392
(GntR)
4 PRO A  42
ALA A  45
ALA A  35
ILE A  40
None
0.78A 5jncD-2du9A:
undetectable
5jncD-2du9A:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dua PHOSPHONOPYRUVATE
HYDROLASE


(Variovorax sp.
Pal2)
PF13714
(PEP_mutase)
4 ALA A  22
ALA A  28
ILE A  39
LEU A  78
None
0.71A 5jncD-2duaA:
undetectable
5jncD-2duaA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gju 252AA LONG
HYPOTHETICAL PROTEIN


(Pyrococcus
horikoshii)
no annotation 4 ALA A  16
ALA A 205
ILE A 195
LEU A   7
None
0.79A 5jncD-2gjuA:
undetectable
5jncD-2gjuA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2icp ANTITOXIN HIGA

(Escherichia
coli)
PF01381
(HTH_3)
4 PRO A  35
ALA A  38
ALA A  28
ILE A  33
None
None
None
MG  A5001 ( 4.3A)
0.71A 5jncD-2icpA:
undetectable
5jncD-2icpA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jsw TALIN-1

(Mus musculus)
PF01608
(I_LWEQ)
4 ALA A2466
ALA A2348
ILE A2352
LEU A2407
None
0.81A 5jncD-2jswA:
undetectable
5jncD-2jswA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nsa TRIGGER FACTOR

(Thermotoga
maritima)
PF05698
(Trigger_C)
4 PRO A 371
ALA A 374
ALA A 364
ILE A 369
None
0.73A 5jncD-2nsaA:
undetectable
5jncD-2nsaA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p6p GLYCOSYL TRANSFERASE

(Streptomyces
fradiae)
PF06722
(DUF1205)
4 PRO A 306
ALA A 287
ALA A 315
LEU A 303
None
0.78A 5jncD-2p6pA:
undetectable
5jncD-2p6pA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vxy CELL DIVISION
PROTEIN FTSZ


(Bacillus
subtilis)
PF00091
(Tubulin)
PF12327
(FtsZ_C)
4 PRO A 115
ALA A 118
ALA A 157
LEU A 161
None
0.74A 5jncD-2vxyA:
undetectable
5jncD-2vxyA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ymv ACG NITROREDUCTASE

(Mycolicibacterium
smegmatis)
no annotation 4 ALA A  19
ALA A  74
ILE A 118
LEU A 119
None
0.81A 5jncD-2ymvA:
undetectable
5jncD-2ymvA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ze3 DFA0005

(Deinococcus
ficus)
PF13714
(PEP_mutase)
4 ALA A 182
ALA A 150
ILE A 132
LEU A 129
None
0.72A 5jncD-2ze3A:
undetectable
5jncD-2ze3A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zw4 BLEOMYCIN
ACETYLTRANSFERASE


(Streptomyces
verticillus)
PF13302
(Acetyltransf_3)
4 ALA A 269
ALA A 204
ILE A 287
LEU A 295
None
0.70A 5jncD-2zw4A:
undetectable
5jncD-2zw4A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a9x SELENOCYSTEINE LYASE

(Rattus
norvegicus)
PF00266
(Aminotran_5)
4 PRO A 288
ALA A 291
ALA A  41
ILE A  62
None
0.61A 5jncD-3a9xA:
undetectable
5jncD-3a9xA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ajx 3-HEXULOSE-6-PHOSPHA
TE SYNTHASE


(Mycobacterium
gastri)
PF00215
(OMPdecase)
4 ALA A1078
ALA A1058
ILE A1044
LEU A1041
None
0.58A 5jncD-3ajxA:
undetectable
5jncD-3ajxA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dnp STRESS RESPONSE
PROTEIN YHAX


(Bacillus
subtilis)
PF08282
(Hydrolase_3)
4 ALA A 251
ALA A 239
ILE A 231
LEU A 228
None
0.76A 5jncD-3dnpA:
undetectable
5jncD-3dnpA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e82 PUTATIVE
OXIDOREDUCTASE


(Klebsiella
pneumoniae)
PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C)
4 PRO A  67
ALA A  70
ALA A  47
ILE A  64
None
0.79A 5jncD-3e82A:
undetectable
5jncD-3e82A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gzd SELENOCYSTEINE LYASE

(Homo sapiens)
PF00266
(Aminotran_5)
4 PRO C 300
ALA C 303
ALA C  53
ILE C  74
None
0.64A 5jncD-3gzdC:
undetectable
5jncD-3gzdC:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0r ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B


(Aquifex
aeolicus)
PF02637
(GatB_Yqey)
PF02934
(GatB_N)
5 PRO B 369
ALA B 373
ALA B 333
ILE B 343
LEU B 347
None
1.19A 5jncD-3h0rB:
undetectable
5jncD-3h0rB:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ibr BACTERIOPHYTOCHROME

(Pseudomonas
aeruginosa)
PF00360
(PHY)
PF01590
(GAF)
PF08446
(PAS_2)
4 ALA A  41
ALA A  53
ILE A  45
LEU A  49
None
0.74A 5jncD-3ibrA:
undetectable
5jncD-3ibrA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ik4 MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN


(Herpetosiphon
aurantiacus)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
4 ALA A 247
ALA A 243
ILE A 265
LEU A 289
None
0.59A 5jncD-3ik4A:
undetectable
5jncD-3ik4A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k2z LEXA REPRESSOR

(Thermotoga
maritima)
PF00717
(Peptidase_S24)
PF01726
(LexA_DNA_bind)
4 PRO A  39
ALA A  42
ALA A  32
ILE A  37
None
0.78A 5jncD-3k2zA:
undetectable
5jncD-3k2zA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lye OXALOACETATE ACETYL
HYDROLASE


(Cryphonectria
parasitica)
PF13714
(PEP_mutase)
4 ALA A 253
ALA A 228
ILE A 210
LEU A 207
None
0.35A 5jncD-3lyeA:
undetectable
5jncD-3lyeA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ndo DEOXYRIBOSE-PHOSPHAT
E ALDOLASE


(Mycolicibacterium
smegmatis)
PF01791
(DeoC)
4 ALA A  66
ALA A  82
ILE A  93
LEU A 126
None
0.67A 5jncD-3ndoA:
undetectable
5jncD-3ndoA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ng3 DEOXYRIBOSE-PHOSPHAT
E ALDOLASE


(Mycobacterium
avium)
PF01791
(DeoC)
4 ALA A  64
ALA A  80
ILE A  91
LEU A 124
None
0.72A 5jncD-3ng3A:
undetectable
5jncD-3ng3A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3niw HALOACID
DEHALOGENASE-LIKE
HYDROLASE


(Bacteroides
thetaiotaomicron)
PF08282
(Hydrolase_3)
4 ALA A 247
ALA A 235
ILE A 227
LEU A 224
None
0.72A 5jncD-3niwA:
undetectable
5jncD-3niwA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nz4 PHENYLALANINE
AMMONIA-LYASE


(Taxus
canadensis)
PF00221
(Lyase_aromatic)
4 ALA A 186
ALA A 183
ILE A 105
LEU A 104
None
None
None
TCA  A 699 (-4.8A)
0.81A 5jncD-3nz4A:
undetectable
5jncD-3nz4A:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oib ACYL-COA
DEHYDROGENASE


(Mycolicibacterium
smegmatis)
PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N)
4 ALA A 192
ALA A 163
ILE A 205
LEU A 245
None
0.78A 5jncD-3oibA:
undetectable
5jncD-3oibA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qdf 2-HYDROXYHEPTA-2,4-D
IENE-1,7-DIOATE
ISOMERASE


(Mycobacterium
marinum)
PF01557
(FAA_hydrolase)
PF10370
(DUF2437)
4 ALA A  15
ALA A  29
ILE A   6
LEU A  54
None
0.82A 5jncD-3qdfA:
undetectable
5jncD-3qdfA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qh4 ESTERASE LIPW

(Mycobacterium
marinum)
PF07859
(Abhydrolase_3)
4 PRO A 124
ALA A  93
ILE A  30
LEU A  31
None
0.79A 5jncD-3qh4A:
undetectable
5jncD-3qh4A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r2g INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE


(Legionella
pneumophila)
PF00478
(IMPDH)
4 ALA A 222
ALA A 204
ILE A 192
LEU A 189
None
0.34A 5jncD-3r2gA:
undetectable
5jncD-3r2gA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r8r TRANSALDOLASE

(Bacillus
subtilis)
PF00923
(TAL_FSA)
4 ALA A 180
ALA A 163
ILE A 145
LEU A 142
None
0.47A 5jncD-3r8rA:
undetectable
5jncD-3r8rA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s8m ENOYL-ACP REDUCTASE

(Xanthomonas
oryzae)
PF07055
(Eno-Rase_FAD_bd)
PF12241
(Enoyl_reductase)
PF12242
(Eno-Rase_NADH_b)
4 PRO A 283
ALA A 169
ALA A 180
ILE A 178
None
0.80A 5jncD-3s8mA:
undetectable
5jncD-3s8mA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tcm ALANINE
AMINOTRANSFERASE 2


(Hordeum vulgare)
PF00155
(Aminotran_1_2)
4 ALA A 126
ALA A 139
ILE A 142
LEU A 144
None
0.80A 5jncD-3tcmA:
undetectable
5jncD-3tcmA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vcr PUTATIVE KDPG
(2-KETO-3-DEOXY-6-PH
OSPHOGLUCONATE)
ALDOLASE


(Oleispira
antarctica)
PF01081
(Aldolase)
4 ALA A  85
ALA A  68
ILE A  54
LEU A  51
None
0.75A 5jncD-3vcrA:
undetectable
5jncD-3vcrA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wgk CELL DIVISION
PROTEIN FTSZ


(Staphylococcus
aureus)
PF00091
(Tubulin)
PF12327
(FtsZ_C)
4 PRO A 115
ALA A 118
ALA A 157
LEU A 161
None
0.75A 5jncD-3wgkA:
undetectable
5jncD-3wgkA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4amg SNOGD

(Streptomyces
nogalater)
PF06722
(DUF1205)
4 ALA A 100
ALA A 163
ILE A 160
LEU A 156
None
0.81A 5jncD-4amgA:
undetectable
5jncD-4amgA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4are COLLAGENASE G

(Hathewaya
histolytica)
PF01752
(Peptidase_M9)
PF08453
(Peptidase_M9_N)
4 ALA A 366
ALA A 379
ILE A 343
LEU A 346
None
0.82A 5jncD-4areA:
undetectable
5jncD-4areA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b3i FATTY ACID
BETA-OXIDATION
COMPLEX BETA-CHAIN
FADA


(Mycobacterium
tuberculosis)
PF00108
(Thiolase_N)
PF02803
(Thiolase_C)
4 ALA C 102
ALA C 116
ILE C  55
LEU C  88
None
0.71A 5jncD-4b3iC:
undetectable
5jncD-4b3iC:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b3k BETA-GLUCOSIDASE

(Streptococcus
pyogenes)
PF00232
(Glyco_hydro_1)
4 ALA A 255
ALA A 197
ILE A 286
LEU A 283
None
0.64A 5jncD-4b3kA:
undetectable
5jncD-4b3kA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cpd ALCOHOL
DEHYDROGENASE


(Thermus sp.
ATN1)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
4 ALA A 214
ALA A 198
ILE A 185
LEU A 182
None
0.54A 5jncD-4cpdA:
undetectable
5jncD-4cpdA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dd5 ACETYL-COA
ACETYLTRANSFERASE


(Clostridioides
difficile)
PF00108
(Thiolase_N)
PF02803
(Thiolase_C)
4 ALA A  12
ALA A  46
ILE A 274
LEU A 272
None
0.62A 5jncD-4dd5A:
undetectable
5jncD-4dd5A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dio NAD(P)
TRANSHYDROGENASE
SUBUNIT ALPHA PART 1


(Sinorhizobium
meliloti)
PF01262
(AlaDh_PNT_C)
PF05222
(AlaDh_PNT_N)
4 ALA A 240
ALA A 224
ILE A 212
LEU A 209
None
0.55A 5jncD-4dioA:
undetectable
5jncD-4dioA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ex5 LYSINE--TRNA LIGASE

(Burkholderia
thailandensis)
PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon)
4 ALA A 301
ALA A 308
ILE A 310
LEU A 317
None
0.78A 5jncD-4ex5A:
undetectable
5jncD-4ex5A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fwt ELONGATION FACTOR
TS, ELONGATION
FACTOR TU, LINKER, Q
BETA REPLICASE


(Escherichia
coli;
Escherichia
virus Qbeta)
PF00009
(GTP_EFTU)
PF00889
(EF_TS)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2)
PF03431
(RNA_replicase_B)
4 ALA A 315
ALA A 462
ILE A 473
LEU A 474
None
0.79A 5jncD-4fwtA:
undetectable
5jncD-4fwtA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j16 NAD/NADP
TRANSHYDROGENASE
ALPHA SUBUNIT 1


(Thermus
thermophilus)
PF01262
(AlaDh_PNT_C)
PF05222
(AlaDh_PNT_N)
4 ALA A 211
ALA A 195
ILE A 183
LEU A 180
None
0.41A 5jncD-4j16A:
undetectable
5jncD-4j16A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lrs 4-HYDROXY-2-OXOVALER
ATE ALDOLASE


(Thermomonospora
curvata)
PF00682
(HMGL-like)
PF07836
(DmpG_comm)
5 PRO A 312
ALA A 313
ALA A 306
ILE A 316
LEU A 340
None
1.47A 5jncD-4lrsA:
undetectable
5jncD-4lrsA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lsb LYASE/MUTASE

(Burkholderia
cenocepacia)
PF13714
(PEP_mutase)
4 ALA A 111
ALA A  86
ILE A  73
LEU A  70
None
0.52A 5jncD-4lsbA:
undetectable
5jncD-4lsbA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m0p RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE 1


(Homo sapiens)
PF13793
(Pribosyltran_N)
PF14572
(Pribosyl_synth)
4 ALA A 121
ALA A  87
ILE A  74
LEU A  71
None
0.60A 5jncD-4m0pA:
undetectable
5jncD-4m0pA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4me9 TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY


(Bacillus cereus)
PF00440
(TetR_N)
PF16295
(TetR_C_10)
4 PRO A  28
ALA A  31
ALA A  38
ILE A  41
None
0.71A 5jncD-4me9A:
undetectable
5jncD-4me9A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q73 PROLINE
DEHYDROGENASE


(Bradyrhizobium
diazoefficiens)
PF00171
(Aldedh)
PF01619
(Pro_dh)
PF14850
(Pro_dh-DNA_bdg)
5 PRO A 485
ALA A 368
ALA A 488
ILE A 489
LEU A  24
None
SO4  A2004 (-3.3A)
SO4  A2004 ( 4.2A)
None
None
1.42A 5jncD-4q73A:
undetectable
5jncD-4q73A:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rlv ANKYRIN-1, ANKYRIN-2

(Homo sapiens;
Mus musculus)
PF00023
(Ank)
PF12796
(Ank_2)
PF13637
(Ank_4)
PF13857
(Ank_5)
5 PRO A2194
ALA A2195
ALA A2168
ILE A2198
LEU A1614
None
1.12A 5jncD-4rlvA:
undetectable
5jncD-4rlvA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ry8 PERIPLASMIC BINDING
PROTEIN


(Pseudothermotoga
lettingae)
PF13407
(Peripla_BP_4)
4 ALA A  93
ALA A 285
ILE A  37
LEU A  67
None
0.81A 5jncD-4ry8A:
undetectable
5jncD-4ry8A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tvr E3 UBIQUITIN-PROTEIN
LIGASE UHRF2


(Homo sapiens)
PF00628
(PHD)
PF12148
(TTD)
4 ALA A 146
ALA A 135
ILE A 211
LEU A 222
None
0.68A 5jncD-4tvrA:
undetectable
5jncD-4tvrA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u39 CELL DIVISION
PROTEIN FTSZ


(Bacillus
subtilis)
PF00091
(Tubulin)
PF12327
(FtsZ_C)
4 PRO A 115
ALA A 118
ALA A 157
LEU A 161
None
0.75A 5jncD-4u39A:
undetectable
5jncD-4u39A:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uek GALACTITOL-1-PHOSPHA
TE 5-DEHYDROGENASE


(Escherichia
coli)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
4 ALA A 206
ALA A 190
ILE A 177
LEU A 174
None
0.60A 5jncD-4uekA:
undetectable
5jncD-4uekA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xbz EVDO1

(Micromonospora
carbonacea)
PF05721
(PhyH)
5 PRO A  96
ALA A  94
ALA A  54
ILE A  97
LEU A 100
None
1.29A 5jncD-4xbzA:
undetectable
5jncD-4xbzA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xri PUTATIVE
UNCHARACTERIZED
PROTEIN


(Chaetomium
thermophilum)
PF03810
(IBN_N)
PF13513
(HEAT_EZ)
4 ALA A 232
ALA A 244
ILE A 202
LEU A 205
None
0.80A 5jncD-4xriA:
undetectable
5jncD-4xriA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zdn AT-LESS POLYKETIDE
SYNTHASE


(Streptomyces
platensis)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc)
4 PRO A 634
ALA A 637
ALA A 627
ILE A 632
None
0.79A 5jncD-4zdnA:
undetectable
5jncD-4zdnA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ayn SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER)


(Bdellovibrio
bacteriovorus)
PF06963
(FPN1)
4 ALA A  26
ALA A 173
ILE A 192
LEU A 189
None
0.82A 5jncD-5aynA:
undetectable
5jncD-5aynA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d7z LACTOYLGLUTATHIONE
LYASE


(Zea mays)
PF00903
(Glyoxalase)
4 PRO A 122
ALA A 133
ALA A 108
ILE A 118
None
0.74A 5jncD-5d7zA:
undetectable
5jncD-5d7zA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d7z LACTOYLGLUTATHIONE
LYASE


(Zea mays)
PF00903
(Glyoxalase)
4 PRO A 256
ALA A 267
ALA A 238
ILE A 252
None
0.79A 5jncD-5d7zA:
undetectable
5jncD-5d7zA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e59 FRNE PROTEIN

(Deinococcus
radiodurans)
PF01323
(DSBA)
4 PRO A  78
ALA A  81
ALA A  71
ILE A  76
None
0.74A 5jncD-5e59A:
undetectable
5jncD-5e59A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ehf LACCASE

(Antrodiella
faginea)
PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3)
4 PRO A 375
ALA A 466
ALA A 364
ILE A 373
None
0.71A 5jncD-5ehfA:
undetectable
5jncD-5ehfA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5epg ALDEHYDE OXIDASE

(Homo sapiens)
PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C)
4 ALA A 336
ALA A 427
ILE A 371
LEU A 368
None
0.80A 5jncD-5epgA:
undetectable
5jncD-5epgA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gnc AVH146

(Phytophthora
sojae)
no annotation 4 ALA A 163
ALA A 153
ILE A 150
LEU A 146
None
0.81A 5jncD-5gncA:
undetectable
5jncD-5gncA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzy (R)-2-HALOACID
DEHALOGENASE


(Pseudomonas
putida)
PF10778
(DehI)
4 ALA A  82
ALA A 246
ILE A 136
LEU A 135
None
0.82A 5jncD-5gzyA:
undetectable
5jncD-5gzyA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5has SEC7

(Thielavia
terrestris)
PF12783
(Sec7_N)
PF16213
(DCB)
4 ALA A  55
ALA A  67
ILE A  14
LEU A  11
None
0.73A 5jncD-5hasA:
undetectable
5jncD-5hasA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j44 SERINE PROTEASE SEPA
AUTOTRANSPORTER


(Shigella
flexneri)
PF02395
(Peptidase_S6)
4 PRO A 985
ALA A 973
ILE A 987
LEU A 959
None
0.79A 5jncD-5j44A:
undetectable
5jncD-5j44A:
13.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jn9 CARBONIC ANHYDRASE 4

(Homo sapiens)
PF00194
(Carb_anhydrase)
5 PRO A 101
ALA A 115
ALA A 150
ILE A 223
LEU A 224
None
0.14A 5jncD-5jn9A:
44.6
5jncD-5jn9A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lzl DELTA-AMINOLEVULINIC
ACID DEHYDRATASE


(Pyrobaculum
calidifontis)
PF00490
(ALAD)
4 ALA A 280
ALA A 259
ILE A 312
LEU A 309
None
0.66A 5jncD-5lzlA:
undetectable
5jncD-5lzlA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lzl DELTA-AMINOLEVULINIC
ACID DEHYDRATASE


(Pyrobaculum
calidifontis)
PF00490
(ALAD)
4 ALA A 317
ALA A 280
ILE A 266
LEU A 263
None
0.57A 5jncD-5lzlA:
undetectable
5jncD-5lzlA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mn5 CELL DIVISION
PROTEIN FTSZ


(Staphylococcus
aureus)
PF00091
(Tubulin)
PF12327
(FtsZ_C)
4 PRO A 115
ALA A 118
ALA A 157
LEU A 161
None
0.83A 5jncD-5mn5A:
undetectable
5jncD-5mn5A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mp7 RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE


(Mycolicibacterium
smegmatis)
PF13793
(Pribosyltran_N)
PF14572
(Pribosyl_synth)
4 ALA A 129
ALA A  95
ILE A  82
LEU A  79
None
0.55A 5jncD-5mp7A:
undetectable
5jncD-5mp7A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o3w PEPTIDE CYCLASE 1

(Gypsophila
vaccaria)
no annotation 4 ALA A 145
ALA A 181
ILE A 158
LEU A 173
None
0.71A 5jncD-5o3wA:
undetectable
5jncD-5o3wA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1


(Saccharomyces
cerevisiae)
PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
4 ALA T3549
ALA T3636
ILE T3632
LEU T3631
None
0.79A 5jncD-5ojsT:
undetectable
5jncD-5ojsT:
5.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vtm TYPE II SECRETION
SYSTEM PROTEIN K


(Pseudomonas
aeruginosa)
no annotation 4 PRO X 235
ALA X 238
ALA X 228
ILE X 233
None
0.74A 5jncD-5vtmX:
undetectable
5jncD-5vtmX:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wol 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE


(Coxiella
burnetii)
PF01113
(DapB_N)
PF05173
(DapB_C)
4 ALA A  73
ALA A  49
ILE A  44
LEU A  40
None
0.70A 5jncD-5wolA:
undetectable
5jncD-5wolA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c3p ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8


(Homo sapiens)
no annotation 4 ALA E1262
ALA E1287
ILE E1156
LEU E1153
None
0.82A 5jncD-6c3pE:
undetectable
5jncD-6c3pE:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6elu SERUM RESISTANCE
ASSOCIATED
VSG PROTEIN


(Trypanosoma
brucei)
no annotation 4 ALA A 116
ALA A  54
ILE A 134
LEU A 137
None
0.76A 5jncD-6eluA:
undetectable
5jncD-6eluA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g1k TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY C
MEMBER 4A


(Danio rerio)
no annotation 4 ALA A 103
ALA A 111
ILE A  78
LEU A  74
None
0.81A 5jncD-6g1kA:
undetectable
5jncD-6g1kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g1o -

(-)
no annotation 4 ALA A 346
ALA A 259
ILE A 240
LEU A 237
None
0.57A 5jncD-6g1oA:
undetectable
5jncD-6g1oA:
undetectable