SIMILAR PATTERNS OF AMINO ACIDS FOR 5JMN_C_FUAC1101

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fon PROCARBOXYPEPTIDASE
A-S6

(Bos taurus) 		PF00089
(Trypsin) 		3 VAL A 168
HIS A 157
VAL A 153
 None
 0.66A 5jmnC-1fonA:
0.0		 5jmnC-1fonA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h2d MATRIX PROTEIN VP40

(Ebola virus sp.) 		PF07447
(VP40) 		3 VAL A  79
HIS A 124
VAL A 133
 None
 0.60A 5jmnC-1h2dA:
0.8		 5jmnC-1h2dA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iq6 (R)-SPECIFIC
ENOYL-COA HYDRATASE

(Aeromonas
caviae) 		PF01575
(MaoC_dehydratas) 		3 VAL A 124
HIS A  53
VAL A  52
 None
 0.71A 5jmnC-1iq6A:
0.0		 5jmnC-1iq6A:
8.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iuq GLYCEROL-3-PHOSPHATE
ACYLTRANSFERASE

(Cucurbita
moschata) 		PF01553
(Acyltransferase)
PF14829
(GPAT_N) 		3 VAL A 307
HIS A 270
VAL A 133
 None
 0.65A 5jmnC-1iuqA:
0.0		 5jmnC-1iuqA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lq1 STAGE 0 SPORULATION
PROTEIN A

(Bacillus
subtilis) 		PF08769
(Spo0A_C) 		3 VAL A 256
HIS A 162
VAL A 166
 None
 0.70A 5jmnC-1lq1A:
undetectable		 5jmnC-1lq1A:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mhq ADP-RIBOSYLATION
FACTOR BINDING
PROTEIN GGA2

(Homo sapiens) 		PF00790
(VHS) 		3 VAL A  53
HIS A  98
VAL A 101
 None
 0.60A 5jmnC-1mhqA:
2.4		 5jmnC-1mhqA:
9.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o7d LYSOSOMAL
ALPHA-MANNOSIDASE

(Bos taurus) 		PF07748
(Glyco_hydro_38C) 		3 VAL D 672
HIS D 814
VAL D 813
 None
 0.67A 5jmnC-1o7dD:
0.0		 5jmnC-1o7dD:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oll NK RECEPTOR

(Homo sapiens) 		no annotation 3 VAL A 182
HIS A 105
VAL A 116
 None
 0.68A 5jmnC-1ollA:
0.0		 5jmnC-1ollA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p6f NATURAL CYTOTOXICITY
TRIGGERING RECEPTOR
1

(Homo sapiens) 		no annotation 3 VAL A 185
HIS A 108
VAL A 119
 None
 0.72A 5jmnC-1p6fA:
0.0		 5jmnC-1p6fA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q51 MENB

(Mycobacterium
tuberculosis) 		PF00378
(ECH_1) 		3 VAL A  82
HIS A  40
VAL A  28
 None
 0.59A 5jmnC-1q51A:
undetectable		 5jmnC-1q51A:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1se8 SINGLE-STRAND
BINDING PROTEIN

(Deinococcus
radiodurans) 		PF00436
(SSB) 		3 VAL A 223
HIS A 176
VAL A 160
 None
 0.70A 5jmnC-1se8A:
0.0		 5jmnC-1se8A:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sj8 TALIN 1

(Mus musculus) 		PF09141
(Talin_middle) 		3 VAL A 591
HIS A 544
VAL A 547
 None
 0.55A 5jmnC-1sj8A:
undetectable		 5jmnC-1sj8A:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wdw TRYPTOPHAN SYNTHASE
BETA CHAIN 1

(Pyrococcus
furiosus) 		PF00291
(PALP) 		3 VAL B 368
HIS B 348
VAL B 250
 None
 0.64A 5jmnC-1wdwB:
undetectable		 5jmnC-1wdwB:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wx4 TYROSINASE

(Streptomyces
castaneoglobisporus) 		PF00264
(Tyrosinase) 		3 VAL A 156
HIS A 190
VAL A 193
 None
CU  A 401 ( 3.2A)
None
 0.67A 5jmnC-1wx4A:
undetectable		 5jmnC-1wx4A:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x9n DNA LIGASE I

(Homo sapiens) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		3 VAL A 510
HIS A 531
VAL A 519
 None
 0.67A 5jmnC-1x9nA:
undetectable		 5jmnC-1x9nA:
22.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xdw NAD+-DEPENDENT
(R)-2-HYDROXYGLUTARA
TE DEHYDROGENASE

(Acidaminococcus
fermentans) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		3 VAL A 111
HIS A 166
VAL A 172
 None
 0.70A 5jmnC-1xdwA:
undetectable		 5jmnC-1xdwA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a0u INITIATION FACTOR 2B

(Leishmania
major) 		PF01008
(IF-2B) 		3 VAL A 261
HIS A 162
VAL A 364
 None
 0.70A 5jmnC-2a0uA:
undetectable		 5jmnC-2a0uA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cb5 PROTEIN (BLEOMYCIN
HYDROLASE)

(Homo sapiens) 		PF03051
(Peptidase_C1_2) 		3 VAL A 433
HIS A 428
VAL A 424
 None
 0.67A 5jmnC-2cb5A:
undetectable		 5jmnC-2cb5A:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cwa SINGLE-STRAND
BINDING PROTEIN

(Thermus
thermophilus) 		PF00436
(SSB) 		3 VAL A 218
HIS A 171
VAL A 159
 None
 0.62A 5jmnC-2cwaA:
undetectable		 5jmnC-2cwaA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dqb DEOXYGUANOSINETRIPHO
SPHATE
TRIPHOSPHOHYDROLASE,
PUTATIVE

(Thermus
thermophilus) 		PF01966
(HD)
PF13286
(HD_assoc) 		3 VAL A 191
HIS A 264
VAL A 267
 None
 0.47A 5jmnC-2dqbA:
undetectable		 5jmnC-2dqbA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e3d UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE

(Escherichia
coli) 		PF00483
(NTP_transferase) 		3 VAL A  60
HIS A 123
VAL A 126
 None
 0.60A 5jmnC-2e3dA:
undetectable		 5jmnC-2e3dA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eae ALPHA-FUCOSIDASE

(Bifidobacterium
bifidum) 		PF14498
(Glyco_hyd_65N_2) 		3 VAL A 168
HIS A 172
VAL A 152
 None
 0.66A 5jmnC-2eaeA:
undetectable		 5jmnC-2eaeA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ihf SINGLE-STRANDED
DNA-BINDING PROTEIN

(Thermus
aquaticus) 		PF00436
(SSB) 		3 VAL A 219
HIS A 172
VAL A 159
 None
 0.64A 5jmnC-2ihfA:
undetectable		 5jmnC-2ihfA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mev MENGO VIRUS COAT
PROTEIN (SUBUNIT
VP2)

(Cardiovirus A) 		PF00073
(Rhv) 		3 VAL 2  34
HIS 2  40
VAL 2 241
 None
 0.68A 5jmnC-2mev2:
undetectable		 5jmnC-2mev2:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nvo RO SIXTY-RELATED
PROTEIN, RSR

(Deinococcus
radiodurans) 		PF05731
(TROVE) 		3 VAL A 200
HIS A 223
VAL A 219
 None
 0.68A 5jmnC-2nvoA:
3.6		 5jmnC-2nvoA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ot9 HYPOTHETICAL PROTEIN

(Pseudomonas
syringae group
genomosp. 3) 		PF07152
(YaeQ) 		3 VAL A 132
HIS A 168
VAL A 161
 None
 0.71A 5jmnC-2ot9A:
undetectable		 5jmnC-2ot9A:
10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p4h VESTITONE REDUCTASE

(Medicago sativa) 		PF01370
(Epimerase) 		3 VAL X 258
HIS X 230
VAL X 195
 None
 0.52A 5jmnC-2p4hX:
undetectable		 5jmnC-2p4hX:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qrw HEMOGLOBIN-LIKE
PROTEIN HBO

(Mycobacterium
tuberculosis) 		PF01152
(Bac_globin) 		3 VAL A  96
HIS A 108
VAL A   9
 None
 0.67A 5jmnC-2qrwA:
2.8		 5jmnC-2qrwA:
8.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rdy BH0842 PROTEIN

(Bacillus
halodurans) 		PF14498
(Glyco_hyd_65N_2) 		3 VAL A 108
HIS A 113
VAL A 125
 None
 0.72A 5jmnC-2rdyA:
undetectable		 5jmnC-2rdyA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vd9 ALANINE RACEMASE

(Bacillus
anthracis) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		3 VAL A 256
HIS A 323
VAL A 309
 MLY  A 255 ( 3.4A)
None
MLY  A 307 ( 4.1A)
 0.60A 5jmnC-2vd9A:
undetectable		 5jmnC-2vd9A:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w8d PROCESSED GLYCEROL
PHOSPHATE
LIPOTEICHOIC ACID
SYNTHASE 2

(Bacillus
subtilis) 		PF00884
(Sulfatase) 		3 VAL A 247
HIS A 532
VAL A 536
 None
 0.70A 5jmnC-2w8dA:
undetectable		 5jmnC-2w8dA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zkg E3 UBIQUITIN-PROTEIN
LIGASE UHRF1

(Mus musculus) 		PF02182
(SAD_SRA) 		3 VAL A 429
HIS A 447
VAL A 540
 None
 0.53A 5jmnC-2zkgA:
undetectable		 5jmnC-2zkgA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3afo NADH KINASE POS5

(Saccharomyces
cerevisiae) 		PF01513
(NAD_kinase) 		3 VAL A 103
HIS A 127
VAL A  34
 None
 0.69A 5jmnC-3afoA:
undetectable		 5jmnC-3afoA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3anx SPERMIDINE SYNTHASE

(Thermus
thermophilus) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		3 VAL A 301
HIS A 206
VAL A 209
 None
 0.66A 5jmnC-3anxA:
undetectable		 5jmnC-3anxA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cvj PUTATIVE
PHOSPHOHEPTOSE
ISOMERASE

(Bacillus
halodurans) 		PF13580
(SIS_2) 		3 VAL A 219
HIS A 208
VAL A 211
 None
 0.52A 5jmnC-3cvjA:
undetectable		 5jmnC-3cvjA:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d5e PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE

(Homo sapiens) 		PF03403
(PAF-AH_p_II) 		3 VAL A 269
HIS A 151
VAL A 177
 None
 0.71A 5jmnC-3d5eA:
undetectable		 5jmnC-3d5eA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dgz THIOREDOXIN
REDUCTASE 2

(Mus musculus) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		3 VAL A 279
HIS A 250
VAL A 165
 None
 0.72A 5jmnC-3dgzA:
undetectable		 5jmnC-3dgzA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e0s UNCHARACTERIZED
PROTEIN

(Chlorobaculum
tepidum) 		PF05235
(CHAD) 		3 VAL A 379
HIS A 222
VAL A 225
 None
 0.55A 5jmnC-3e0sA:
2.2		 5jmnC-3e0sA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g5j PUTATIVE ATP/GTP
BINDING PROTEIN

(Clostridioides
difficile) 		PF00581
(Rhodanese) 		3 VAL A  68
HIS A  45
VAL A  48
 None
GOL  A 303 (-3.5A)
None
 0.71A 5jmnC-3g5jA:
undetectable		 5jmnC-3g5jA:
9.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gnr OS03G0212800 PROTEIN

(Oryza sativa) 		PF00232
(Glyco_hydro_1) 		3 VAL A 316
HIS A 320
VAL A 250
 VAL  A 316 ( 0.6A)
HIS  A 320 ( 1.0A)
VAL  A 250 ( 0.6A)
 0.65A 5jmnC-3gnrA:
undetectable		 5jmnC-3gnrA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3goc ENDONUCLEASE V

(Streptomyces
avermitilis) 		PF04493
(Endonuclease_5) 		3 VAL A 185
HIS A 195
VAL A 191
 None
 0.62A 5jmnC-3gocA:
undetectable		 5jmnC-3gocA:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ijm UNCHARACTERIZED
RESTRICTION
ENDONUCLEASE-LIKE
FOLD SUPERFAMILY
PROTEIN

(Spirosoma
linguale) 		no annotation 3 VAL A  13
HIS A  26
VAL A  29
 None
NA  A 151 (-3.5A)
None
 0.56A 5jmnC-3ijmA:
undetectable		 5jmnC-3ijmA:
9.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j7a 40S RIBOSOMAL
PROTEIN US11

(Plasmodium
falciparum) 		PF00411
(Ribosomal_S11) 		3 VAL P 132
HIS P  94
VAL P  30
 None
 0.49A 5jmnC-3j7aP:
undetectable		 5jmnC-3j7aP:
9.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k32 UNCHARACTERIZED
PROTEIN MJ0690

(Methanocaldococcus
jannaschii) 		no annotation 3 VAL A  67
HIS A  88
VAL A  91
 None
 0.70A 5jmnC-3k32A:
undetectable		 5jmnC-3k32A:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l5j INTERLEUKIN-6
RECEPTOR SUBUNIT
BETA

(Homo sapiens) 		PF00041
(fn3) 		3 VAL A 474
HIS A 456
VAL A 455
 None
 0.71A 5jmnC-3l5jA:
undetectable		 5jmnC-3l5jA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ldr FRUCTOSYLTRANSFERASE

(Aspergillus
japonicus) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		3 VAL A 382
HIS A  64
VAL A 394
 None
 0.71A 5jmnC-3ldrA:
undetectable		 5jmnC-3ldrA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1g PUTATIVE GLUTATHIONE
S-TRANSFERASE

(Corynebacterium
glutamicum) 		PF13409
(GST_N_2)
PF13410
(GST_C_2) 		3 VAL A 135
HIS A  71
VAL A  74
 None
 0.55A 5jmnC-3m1gA:
undetectable		 5jmnC-3m1gA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3myr NICKEL-DEPENDENT
HYDROGENASE LARGE
SUBUNIT

(Allochromatium
vinosum) 		PF00374
(NiFeSe_Hases) 		3 VAL B1441
HIS B1102
VAL B1105
 None
 0.67A 5jmnC-3myrB:
undetectable		 5jmnC-3myrB:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o31 THERMONICOTIANAMINE
SYNTHASE

(Methanothermobacter
thermautotrophicus) 		PF03059
(NAS) 		3 VAL A 149
HIS A 143
VAL A 171
 None
 0.65A 5jmnC-3o31A:
undetectable		 5jmnC-3o31A:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p4s FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT

(Escherichia
coli) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		3 VAL A  86
HIS A  67
VAL A  70
 None
 0.67A 5jmnC-3p4sA:
2.3		 5jmnC-3p4sA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p69 UNCHARACTERIZED
PROTEIN

(Bacteroides
fragilis) 		no annotation 3 VAL A 118
HIS A 137
VAL A 153
 None
 0.61A 5jmnC-3p69A:
undetectable		 5jmnC-3p69A:
8.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pop GILR OXIDASE

(Streptomyces
griseoflavus) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		3 VAL A  99
HIS A 152
VAL A 149
 None
 0.63A 5jmnC-3popA:
2.9		 5jmnC-3popA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qha PUTATIVE
OXIDOREDUCTASE

(Mycobacterium
avium) 		PF03446
(NAD_binding_2)
PF14833
(NAD_binding_11) 		3 VAL A 143
HIS A 121
VAL A  96
 None
 0.69A 5jmnC-3qhaA:
undetectable		 5jmnC-3qhaA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ul5 CANECYSTATIN-1

(Saccharum
officinarum) 		PF16845
(SQAPI) 		3 VAL A  70
HIS A  66
VAL A  86
 None
 0.72A 5jmnC-3ul5A:
undetectable		 5jmnC-3ul5A:
8.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wvr PGM1

(Streptomyces
cirratus) 		no annotation 3 VAL A 240
HIS A 169
VAL A 172
 None
 0.39A 5jmnC-3wvrA:
undetectable		 5jmnC-3wvrA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b2g GH3-1 AUXIN
CONJUGATING ENZYME

(Vitis vinifera) 		PF03321
(GH3) 		3 VAL A 420
HIS A 392
VAL A 388
 None
 0.69A 5jmnC-4b2gA:
2.2		 5jmnC-4b2gA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ci0 F420-REDUCING
HYDROGENASE, SUBUNIT
ALPHA

(Methanothermobacter
marburgensis) 		PF00374
(NiFeSe_Hases) 		3 VAL A 154
HIS A  70
VAL A  59
 None
FE  A1387 ( 4.6A)
None
 0.68A 5jmnC-4ci0A:
undetectable		 5jmnC-4ci0A:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cz2 RAS-RELATED PROTEIN
RAB-32

(Homo sapiens) 		PF00071
(Ras) 		3 VAL A  28
HIS A  24
VAL A  75
 None
 0.71A 5jmnC-4cz2A:
undetectable		 5jmnC-4cz2A:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fim LACTOTRANSFERRIN

(Bos taurus) 		PF00405
(Transferrin) 		3 VAL A 597
HIS A 606
VAL A 345
 None
 0.66A 5jmnC-4fimA:
undetectable		 5jmnC-4fimA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fww MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR

(Homo sapiens) 		PF01403
(Sema) 		3 VAL A 498
HIS A 463
VAL A 520
 None
 0.70A 5jmnC-4fwwA:
undetectable		 5jmnC-4fwwA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gky PROTEIN ERGIC-53

(Homo sapiens) 		PF03388
(Lectin_leg-like) 		3 VAL A 108
HIS A 257
VAL A  82
 None
 0.65A 5jmnC-4gkyA:
undetectable		 5jmnC-4gkyA:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hhr ALPHA-DIOXYGENASE

(Arabidopsis
thaliana) 		PF03098
(An_peroxidase) 		3 VAL A 599
HIS A 283
VAL A 286
 None
 0.44A 5jmnC-4hhrA:
undetectable		 5jmnC-4hhrA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4huz 2,6-DICHLORO-P-HYDRO
QUINONE
1,2-DIOXYGENASE

(Sphingobium
chlorophenolicum) 		PF00903
(Glyoxalase) 		3 VAL A 133
HIS A 100
VAL A  29
 None
 0.71A 5jmnC-4huzA:
undetectable		 5jmnC-4huzA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hyv PYRUVATE KINASE 1

(Trypanosoma
brucei) 		PF00224
(PK)
PF02887
(PK_C) 		3 VAL A 108
HIS A 170
VAL A 144
 None
 0.51A 5jmnC-4hyvA:
undetectable		 5jmnC-4hyvA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kvl FATTY ACID
ALPHA-OXIDASE

(Oryza sativa) 		PF03098
(An_peroxidase) 		3 VAL A 592
HIS A 276
VAL A 279
 None
 0.44A 5jmnC-4kvlA:
undetectable		 5jmnC-4kvlA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lej VICILIN

(Pinus
koraiensis) 		PF00190
(Cupin_1) 		3 VAL A 196
HIS A 162
VAL A 140
 None
 0.59A 5jmnC-4lejA:
undetectable		 5jmnC-4lejA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4leu PENTATRICOPEPTIDE
REPEAT-CONTAINING
PROTEIN AT3G46870

(Arabidopsis
thaliana) 		PF13041
(PPR_2) 		3 VAL A 132
HIS A 101
VAL A  80
 None
 0.70A 5jmnC-4leuA:
undetectable		 5jmnC-4leuA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mtt LACTOYLGLUTATHIONE
LYASE

(Pseudomonas
aeruginosa) 		PF00903
(Glyoxalase) 		3 VAL A  44
HIS A  59
VAL A  10
 None
CL  A 206 (-3.8A)
None
 0.70A 5jmnC-4mttA:
undetectable		 5jmnC-4mttA:
8.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qbj GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE

(Aspergillus
fumigatus) 		PF01233
(NMT)
PF02799
(NMT_C) 		3 VAL A 473
HIS A 439
VAL A 487
 None
 0.70A 5jmnC-4qbjA:
undetectable		 5jmnC-4qbjA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qn9 N-ACYL-PHOSPHATIDYLE
THANOLAMINE-HYDROLYZ
ING PHOSPHOLIPASE D

(Homo sapiens) 		PF12706
(Lactamase_B_2) 		3 VAL A 272
HIS A 241
VAL A 238
 None
 0.63A 5jmnC-4qn9A:
undetectable		 5jmnC-4qn9A:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qt8 MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR

(Homo sapiens) 		no annotation 3 VAL B 498
HIS B 463
VAL B 520
 None
 0.68A 5jmnC-4qt8B:
undetectable		 5jmnC-4qt8B:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT

(Methylococcus
capsulatus) 		no annotation 3 VAL B 382
HIS B 420
VAL B 438
 None
 0.66A 5jmnC-4tqoB:
undetectable		 5jmnC-4tqoB:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u48 PUTATIVE INNER
MEMBRANE LIPOPROTEIN

(Salmonella
enterica) 		PF00207
(A2M)
PF01835
(A2M_N)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl)
PF11974
(MG1) 		3 VAL A 179
HIS A 186
VAL A 184
 None
 0.64A 5jmnC-4u48A:
undetectable		 5jmnC-4u48A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4umv ZINC-TRANSPORTING
ATPASE

(Shigella sonnei) 		PF00122
(E1-E2_ATPase)
PF00702
(Hydrolase) 		3 VAL A 542
HIS A 523
VAL A 551
 None
 0.68A 5jmnC-4umvA:
undetectable		 5jmnC-4umvA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v19 MITORIBOSOMAL
PROTEIN BL27M,
MRPL27

(Sus scrofa) 		PF01016
(Ribosomal_L27) 		3 VAL 0  61
HIS 0 132
VAL 0  81
 None
 0.58A 5jmnC-4v190:
undetectable		 5jmnC-4v190:
9.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y7d ALPHA/BETA HYDROLASE
FOLD PROTEIN

(Nakamurella
multipartita) 		PF00561
(Abhydrolase_1) 		3 VAL A 100
HIS A  37
VAL A  63
 None
 0.59A 5jmnC-4y7dA:
undetectable		 5jmnC-4y7dA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c7o GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
TESTIS-SPECIFIC

(Homo sapiens) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		3 VAL O 104
HIS O 143
VAL O 140
 None
 0.71A 5jmnC-5c7oO:
undetectable		 5jmnC-5c7oO:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d8m METAGENOMIC CARBOXYL
ESTERASE MGS0156

(uncultured
organism) 		no annotation 3 VAL A 166
HIS A 214
VAL A 217
 None
 0.63A 5jmnC-5d8mA:
undetectable		 5jmnC-5d8mA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ekd TRYPTOPHAN--TRNA
LIGASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00579
(tRNA-synt_1b) 		3 VAL A 217
HIS A 279
VAL A 282
 ATP  A 402 (-3.3A)
None
None
 0.54A 5jmnC-5ekdA:
undetectable		 5jmnC-5ekdA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ex2 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Hirschia
baltica) 		PF00160
(Pro_isomerase) 		3 VAL A 251
HIS A 149
VAL A 153
 None
 0.66A 5jmnC-5ex2A:
undetectable		 5jmnC-5ex2A:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gs2 ANTI-MBP
ANTI-REPEBODY

(Homo sapiens;
Mus musculus) 		PF07686
(V-set) 		3 VAL D  37
HIS H 223
VAL D 108
 None
 0.53A 5jmnC-5gs2D:
1.6		 5jmnC-5gs2D:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ha5 BRUCELLA OVIS
OXIDOREDUCTASE

(Brucella ovis) 		PF13561
(adh_short_C2) 		3 VAL A 188
HIS A 132
VAL A 135
 None
 0.68A 5jmnC-5ha5A:
undetectable		 5jmnC-5ha5A:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kgz MODULIN BETA2

(Staphylococcus
aureus) 		PF05480
(Staph_haemo) 		3 VAL A  31
HIS A  18
VAL A  21
 None
 0.65A 5jmnC-5kgzA:
undetectable		 5jmnC-5kgzA:
3.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kn8 ADENINE DNA
GLYCOSYLASE

(Geobacillus
stearothermophilus) 		PF00633
(HHH)
PF00730
(HhH-GPD) 		3 VAL A  44
HIS A  96
VAL A  99
 None
 0.72A 5jmnC-5kn8A:
undetectable		 5jmnC-5kn8A:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5loi RAD26

(Thermothelomyces
thermophila) 		PF12331
(DUF3636) 		3 VAL A 677
HIS A 765
VAL A 768
 None
 0.62A 5jmnC-5loiA:
undetectable		 5jmnC-5loiA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m3x ANGIOTENSINOGEN

(Homo sapiens) 		no annotation 3 VAL A 100
HIS A 440
VAL A 431
 None
 0.62A 5jmnC-5m3xA:
undetectable		 5jmnC-5m3xA:
6.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mux 2-METHYLCITRATE
DEHYDRATASE

(Bacillus
subtilis) 		no annotation 3 VAL A 396
HIS A 296
VAL A 299
 None
 0.46A 5jmnC-5muxA:
undetectable		 5jmnC-5muxA:
6.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5odr METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
A

(Methanothermococcus
thermolithotrophicus) 		PF00374
(NiFeSe_Hases) 		3 VAL F 228
HIS F 224
VAL F 243
 None
 0.66A 5jmnC-5odrF:
undetectable		 5jmnC-5odrF:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oom 39S RIBOSOMAL
PROTEIN L27,
MITOCHONDRIAL

(Homo sapiens) 		PF01016
(Ribosomal_L27) 		3 VAL W  61
HIS W 132
VAL W  81
 None
 0.70A 5jmnC-5oomW:
2.3		 5jmnC-5oomW:
9.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opt 40S RIBOSOMAL
PROTEIN S3A-2

(Trypanosoma
cruzi) 		no annotation 3 VAL W 187
HIS W 103
VAL W 219
 None
C  E1256 ( 4.5A)
None
 0.66A 5jmnC-5optW:
undetectable		 5jmnC-5optW:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u89 AMINO ACID
ADENYLATION DOMAIN
PROTEIN

(Geobacillus sp.
Y4.1MC1) 		PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00668
(Condensation)
PF13193
(AMP-binding_C) 		3 VAL A 723
HIS A 706
VAL A 709
 None
 0.62A 5jmnC-5u89A:
2.1		 5jmnC-5u89A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x59 S PROTEIN

(Middle East
respiratory
syndrome-related
coronavirus) 		PF01601
(Corona_S2)
PF09408
(Spike_rec_bind) 		3 VAL A 356
HIS A 670
VAL A 661
 None
 0.72A 5jmnC-5x59A:
undetectable		 5jmnC-5x59A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xeq NEUROLIGIN-2

(Homo sapiens) 		PF00135
(COesterase) 		3 VAL A 148
HIS A 251
VAL A  44
 None
 0.67A 5jmnC-5xeqA:
undetectable		 5jmnC-5xeqA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xxu RIBOSOMAL PROTEIN
US11

(Toxoplasma
gondii) 		PF00411
(Ribosomal_S11) 		3 VAL O 137
HIS O  99
VAL O  35
 None
 0.65A 5jmnC-5xxuO:
undetectable		 5jmnC-5xxuO:
10.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xxu RIBOSOMAL PROTEIN
US17

(Toxoplasma
gondii) 		PF00366
(Ribosomal_S17)
PF16205
(Ribosomal_S17_N) 		3 VAL L  77
HIS L 112
VAL L 142
 None
 0.65A 5jmnC-5xxuL:
undetectable		 5jmnC-5xxuL:
8.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyi RIBOSOMAL PROTEIN
S14

(Trichomonas
vaginalis) 		PF00411
(Ribosomal_S11) 		3 VAL O 140
HIS O 102
VAL O  38
 None
 0.58A 5jmnC-5xyiO:
undetectable		 5jmnC-5xyiO:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfz ASK1
DAD2

(Chaetomium
thermophilum) 		no annotation 3 VAL C  52
HIS A  40
VAL A  43
 None
 0.41A 5jmnC-6cfzC:
undetectable		 5jmnC-6cfzC:
5.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fc0 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
4E-LIKE PROTEIN

(Chaetomium
thermophilum) 		no annotation 3 VAL A 164
HIS A 143
VAL A 219
 None
 0.37A 5jmnC-6fc0A:
3.0		 5jmnC-6fc0A:
6.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g2j NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
9, MITOCHONDRIAL

(Mus musculus) 		no annotation 3 VAL P  19
HIS P  37
VAL P  34
 None
 0.72A 5jmnC-6g2jP:
undetectable		 5jmnC-6g2jP:
6.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gru ADP-SUGAR
PYROPHOSPHATASE

(Homo sapiens) 		no annotation 3 VAL A 146
HIS A 142
VAL A  62
 None
 0.72A 5jmnC-6gruA:
undetectable		 5jmnC-6gruA:
5.70