SIMILAR PATTERNS OF AMINO ACIDS FOR 5JM4_B_BEZB301_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1au8 CATHEPSIN G

(Homo sapiens) 		PF00089
(Trypsin) 		4 PHE A 234
ILE A 103
GLN A  93
ARG A 179
 None
 0.97A 5jm4B-1au8A:
undetectable		 5jm4B-1au8A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f6v DNA TRANSPOSITION
PROTEIN

(Escherichia
virus Mu) 		PF09077
(Phage-MuB_C) 		4 PHE A  76
ILE A  21
GLN A  74
ARG A  77
 None
 1.36A 5jm4B-1f6vA:
undetectable		 5jm4B-1f6vA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oki BETA CRYSTALLIN B1

(Homo sapiens) 		PF00030
(Crystall) 		4 PHE A  63
ILE A  94
GLN A  69
ARG A  72
 None
 1.01A 5jm4B-1okiA:
undetectable		 5jm4B-1okiA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1olt OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE

(Escherichia
coli) 		PF04055
(Radical_SAM)
PF06969
(HemN_C) 		4 PHE A  68
ILE A 211
GLN A 179
ARG A 184
 SF4  A 500 ( 4.6A)
SAM  A 501 (-4.3A)
None
SAM  A 501 ( 2.9A)
 1.47A 5jm4B-1oltA:
0.2		 5jm4B-1oltA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a87 THIOREDOXIN
REDUCTASE

(Mycobacterium
tuberculosis) 		PF07992
(Pyr_redox_2) 		4 PHE A  43
ILE A  18
GLN A 111
ARG A  89
 None
 1.07A 5jm4B-2a87A:
1.0		 5jm4B-2a87A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bl0 MAJOR PLASMODIAL
MYOSIN HEAVY CHAIN
MYOSIN REGULATORY
LIGHT CHAIN

(Physarum
polycephalum;
Physarum
polycephalum) 		PF00612
(IQ)
PF00036
(EF-hand_1)
PF13499
(EF-hand_7) 		4 PHE A 800
ILE B  13
GLN B   6
ARG A 804
 None
 1.39A 5jm4B-2bl0A:
undetectable		 5jm4B-2bl0A:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lxj COLD SHOCK-LIKE
PROTEIN CSPLA

(Listeria
monocytogenes) 		PF00313
(CSD) 		4 PHE A  49
ILE A  18
GLN A   3
ARG A  20
 None
 1.39A 5jm4B-2lxjA:
undetectable		 5jm4B-2lxjA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ny0 ENVELOPE
GLYCOPROTEIN GP120

(Human
immunodeficiency
virus 1) 		PF00516
(GP120) 		4 PHE A 468
ILE A 359
GLN A 352
ARG A 456
 None
 0.81A 5jm4B-2ny0A:
undetectable		 5jm4B-2ny0A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q14 PHOSPHOHYDROLASE

(Bacteroides
thetaiotaomicron) 		PF01966
(HD) 		4 PHE A 210
ILE A 186
GLN A 158
ARG A 163
 None
 1.09A 5jm4B-2q14A:
0.3		 5jm4B-2q14A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vvq RIBOSE-5-PHOSPHATE
ISOMERASE B

(Mycobacterium
tuberculosis) 		PF02502
(LacAB_rpiB) 		4 PHE A 127
ILE A 108
GLN A 106
ARG A 100
 None
 1.30A 5jm4B-2vvqA:
0.0		 5jm4B-2vvqA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vz9 FATTY ACID SYNTHASE

(Sus scrofa) 		PF00107
(ADH_zinc_N)
PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF08242
(Methyltransf_12)
PF08659
(KR)
PF14765
(PS-DH)
PF16197
(KAsynt_C_assoc) 		4 PHE A1712
ILE A1685
GLN A1824
ARG A1711
 None
 1.38A 5jm4B-2vz9A:
undetectable		 5jm4B-2vz9A:
6.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wgr GLUTATHIONE
PEROXIDASE

(Schistosoma
mansoni) 		PF00255
(GSHPx) 		4 PHE A 117
ILE A  11
GLN A 122
ARG A 121
 None
 1.33A 5jm4B-2wgrA:
undetectable		 5jm4B-2wgrA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dmk DOWN SYNDROME CELL
ADHESION MOLECULE
(DSCAM) ISOFORM
1.30.30, N-TERMINAL
EIGHT IG DOMAINS

(Drosophila
melanogaster) 		PF07679
(I-set)
PF13927
(Ig_3) 		4 PHE A  63
ILE A  24
GLN A  78
ARG A  53
 None
 0.99A 5jm4B-3dmkA:
undetectable		 5jm4B-3dmkA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jwo HIV-1 GP120 ENVELOPE
GLYCOPROTEIN

(Homo sapiens) 		PF00516
(GP120) 		4 PHE A 468
ILE A 359
GLN A 352
ARG A 456
 None
 0.82A 5jm4B-3jwoA:
undetectable		 5jm4B-3jwoA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oq2 CRISPR-ASSOCIATED
PROTEIN CAS2

(Desulfovibrio
vulgaris) 		PF09827
(CRISPR_Cas2) 		4 PHE A  45
ILE A  29
GLN A  34
ARG A  39
 None
None
None
SO4  A 107 (-3.0A)
 1.31A 5jm4B-3oq2A:
undetectable		 5jm4B-3oq2A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tgq HIV-1 YU2 GP120

(Human
immunodeficiency
virus 1) 		PF00516
(GP120) 		4 PHE A 468
ILE A 359
GLN A 352
ARG A 456
 None
 0.91A 5jm4B-3tgqA:
undetectable		 5jm4B-3tgqA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zpm LATHERIN

(Equus caballus) 		PF01273
(LBP_BPI_CETP) 		4 PHE A  77
ILE A  84
GLN A   2
ARG A 201
 None
 0.99A 5jm4B-3zpmA:
undetectable		 5jm4B-3zpmA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cso ORFY PROTEIN,
TRANSCRIPTION FACTOR

(Thermoproteus
tenax) 		no annotation 4 PHE A 122
ILE A  38
GLN A  33
ARG A  26
 None
 1.46A 5jm4B-4csoA:
undetectable		 5jm4B-4csoA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fdd TRANSPORTIN-1

(Homo sapiens) 		PF03810
(IBN_N)
PF13513
(HEAT_EZ) 		4 PHE A 834
ILE A 833
GLN A 830
ARG A 795
 None
 1.45A 5jm4B-4fddA:
3.0		 5jm4B-4fddA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jpk GERMLINE-TARGETING
HIV-1 GP120
ENGINEERED OUTER
DOMAIN, EOD-GT6

(Human
immunodeficiency
virus 1) 		PF00516
(GP120) 		4 PHE A  38
ILE A 132
GLN A 126
ARG A  26
 None
 1.01A 5jm4B-4jpkA:
undetectable		 5jm4B-4jpkA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lej VICILIN

(Pinus
koraiensis) 		PF00190
(Cupin_1) 		4 PHE A 156
ILE A 137
GLN A 264
ARG A 148
 None
 1.36A 5jm4B-4lejA:
undetectable		 5jm4B-4lejA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lu4 PUTATIVE CELL
FILAMENTATION
PROTEIN

(Bartonella
quintana) 		PF02661
(Fic) 		4 PHE A 173
ILE A 204
GLN A 156
ARG A 157
 None
None
None
IOD  A 307 ( 4.9A)
 1.37A 5jm4B-4lu4A:
1.2		 5jm4B-4lu4A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n1a CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata) 		PF01580
(FtsK_SpoIIIE) 		4 PHE A 908
ILE A 913
GLN A 903
ARG A 904
 None
 1.19A 5jm4B-4n1aA:
2.4		 5jm4B-4n1aA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nh0 CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata) 		PF01580
(FtsK_SpoIIIE) 		4 PHE A 908
ILE A 913
GLN A 903
ARG A 904
 None
 1.09A 5jm4B-4nh0A:
1.5		 5jm4B-4nh0A:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r2g SURFACE PROTEIN
GP160

(Human
immunodeficiency
virus 1) 		no annotation 4 PHE E 468
ILE E 359
GLN E 352
ARG E 456
 None
 1.00A 5jm4B-4r2gE:
undetectable		 5jm4B-4r2gE:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x9f DOWN SYNDROME CELL
ADHESION MOLECULE
ISOFORM 6.9

(Drosophila
melanogaster) 		PF07679
(I-set) 		4 PHE A  63
ILE A  24
GLN A  78
ARG A  53
 None
 1.05A 5jm4B-4x9fA:
undetectable		 5jm4B-4x9fA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ye4 HT593.1 GP120

(Human
immunodeficiency
virus) 		PF00516
(GP120) 		4 PHE G 470
ILE G 359
GLN G 352
ARG G 456
 None
 0.83A 5jm4B-4ye4G:
undetectable		 5jm4B-4ye4G:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z9n AMINO ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN

(Brucella ovis) 		PF00497
(SBP_bac_3) 		4 PHE A 289
ILE A 301
GLN A 315
ARG A 303
 None
 1.42A 5jm4B-4z9nA:
undetectable		 5jm4B-4z9nA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ctr SQUAMOUS CELL
CARCINOMA ANTIGEN
RECOGNIZED BY
T-CELLS 3

(Homo sapiens) 		no annotation 4 PHE A 333
ILE A 329
GLN A 352
ARG A 349
 None
 1.00A 5jm4B-5ctrA:
3.9		 5jm4B-5ctrA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j1d PHOSPHATE BINDING
PROTEIN

(Stenotrophomonas
maltophilia) 		PF12849
(PBP_like_2) 		4 PHE A 351
ILE A  92
GLN A 295
ARG A 350
 None
 1.17A 5jm4B-5j1dA:
0.8		 5jm4B-5j1dA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mje CYTOTOXIC
TRANSLATIONAL
REPRESSOR OF
TOXIN-ANTITOXIN
STABILITY SYSTEM

(Vibrio cholerae) 		PF06296
(RelE) 		4 PHE A  11
ILE A  81
GLN A  28
ARG A  15
 None
 1.37A 5jm4B-5mjeA:
undetectable		 5jm4B-5mjeA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ogz -

(-) 		no annotation 4 PHE A 208
ILE A 213
GLN A 216
ARG A 209
 None
 1.44A 5jm4B-5ogzA:
0.4		 5jm4B-5ogzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t33 RHPA GP120 CORE

(Human
immunodeficiency
virus) 		PF00516
(GP120) 		4 PHE G 468
ILE G 359
GLN G 352
ARG G 456
 None
 1.20A 5jm4B-5t33G:
undetectable		 5jm4B-5t33G:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vn3 ENVELOPE
GLYCOPROTEIN GP160

(Human
immunodeficiency
virus 1) 		PF00516
(GP120) 		4 PHE G 468
ILE G 358
GLN G 352
ARG G 456
 None
 1.12A 5jm4B-5vn3G:
undetectable		 5jm4B-5vn3G:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xu5 ENDO-1,4-BETA-MANNAN
ASE

(Rhizopus
microsporus) 		no annotation 4 PHE B  58
ILE B  57
GLN B  98
ARG B  97
 None
 1.38A 5jm4B-5xu5B:
undetectable		 5jm4B-5xu5B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bym STEROL-BINDING
PROTEIN

(Saccharomyces
cerevisiae) 		no annotation 4 PHE A  73
ILE A 108
GLN A 121
ARG A  83
 None
None
HC3  A 301 (-2.5A)
None
 1.43A 5jm4B-6bymA:
undetectable		 5jm4B-6bymA:
undetectable