SIMILAR PATTERNS OF AMINO ACIDS FOR 5JM4_A_BEZA301_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1au8 CATHEPSIN G

(Homo sapiens) 		PF00089
(Trypsin) 		4 PHE A 234
ILE A 103
GLN A  93
ARG A 179
 None
 1.11A 5jm4A-1au8A:
undetectable		 5jm4A-1au8A:
18.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ib1 14-3-3 ZETA ISOFORM

(Homo sapiens) 		PF00244
(14-3-3) 		4 PHE A 196
ILE A 200
MET A 218
GLN A 219
 None
 1.00A 5jm4A-1ib1A:
32.5		 5jm4A-1ib1A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1knr L-ASPARTATE OXIDASE

(Escherichia
coli) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		4 PHE A 446
ILE A 467
MET A 447
ARG A 466
 None
 1.41A 5jm4A-1knrA:
undetectable		 5jm4A-1knrA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n7d LOW-DENSITY
LIPOPROTEIN RECEPTOR

(Homo sapiens) 		PF00057
(Ldl_recept_a)
PF00058
(Ldl_recept_b)
PF07645
(EGF_CA)
PF14670
(FXa_inhibition) 		4 PHE A 382
ILE A 607
MET A 391
ARG A 389
 None
 1.19A 5jm4A-1n7dA:
undetectable		 5jm4A-1n7dA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1olt OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE

(Escherichia
coli) 		PF04055
(Radical_SAM)
PF06969
(HemN_C) 		4 PHE A  68
ILE A 211
GLN A 179
ARG A 184
 SF4  A 500 ( 4.6A)
SAM  A 501 (-4.3A)
None
SAM  A 501 ( 2.9A)
 1.39A 5jm4A-1oltA:
undetectable		 5jm4A-1oltA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s7h YKOF

(Bacillus
subtilis) 		PF07615
(Ykof) 		4 ILE A 139
MET A 173
GLN A 176
ARG A 172
 None
 1.49A 5jm4A-1s7hA:
undetectable		 5jm4A-1s7hA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ur1 ENDOXYLANASE

(Cellvibrio
mixtus) 		PF00331
(Glyco_hydro_10) 		4 PHE A 183
ILE A 179
MET A 223
GLN A 219
 None
 1.37A 5jm4A-1ur1A:
undetectable		 5jm4A-1ur1A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bl0 MAJOR PLASMODIAL
MYOSIN HEAVY CHAIN
MYOSIN REGULATORY
LIGHT CHAIN

(Physarum
polycephalum;
Physarum
polycephalum) 		PF00612
(IQ)
PF00036
(EF-hand_1)
PF13499
(EF-hand_7) 		4 PHE A 800
ILE B  13
GLN B   6
ARG A 804
 None
 1.40A 5jm4A-2bl0A:
undetectable		 5jm4A-2bl0A:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iwb METHICILLIN
RESISTANCE MECR1
PROTEIN

(Staphylococcus
aureus) 		PF00905
(Transpeptidase) 		4 PHE A 503
ILE A 463
MET A 400
GLN A 404
 None
 1.33A 5jm4A-2iwbA:
undetectable		 5jm4A-2iwbA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j6h GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE

(Escherichia
coli) 		PF01380
(SIS)
PF13522
(GATase_6) 		4 PHE A 575
MET A 447
GLN A 446
ARG A 443
 None
 0.96A 5jm4A-2j6hA:
2.1		 5jm4A-2j6hA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lxj COLD SHOCK-LIKE
PROTEIN CSPLA

(Listeria
monocytogenes) 		PF00313
(CSD) 		4 PHE A  49
ILE A  18
GLN A   3
ARG A  20
 None
 1.44A 5jm4A-2lxjA:
undetectable		 5jm4A-2lxjA:
18.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2npm 14-3-3 DOMAIN
CONTAINING PROTEIN

(Cryptosporidium
parvum) 		PF00244
(14-3-3) 		4 PHE A 225
ILE A 229
MET A 247
GLN A 248
 None
 0.49A 5jm4A-2npmA:
32.1		 5jm4A-2npmA:
55.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ny0 ENVELOPE
GLYCOPROTEIN GP120

(Human
immunodeficiency
virus 1) 		PF00516
(GP120) 		4 PHE A 468
ILE A 359
GLN A 352
ARG A 456
 None
 0.80A 5jm4A-2ny0A:
undetectable		 5jm4A-2ny0A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q14 PHOSPHOHYDROLASE

(Bacteroides
thetaiotaomicron) 		PF01966
(HD) 		4 PHE A 210
ILE A 186
GLN A 158
ARG A 163
 None
 1.11A 5jm4A-2q14A:
undetectable		 5jm4A-2q14A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ux8 GLUCOSE-1-PHOSPHATE
URIDYLYLTRANSFERASE

(Sphingomonas
elodea) 		PF00483
(NTP_transferase) 		4 PHE A 244
ILE A 158
MET A 235
GLN A 236
 None
 1.19A 5jm4A-2ux8A:
undetectable		 5jm4A-2ux8A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vvq RIBOSE-5-PHOSPHATE
ISOMERASE B

(Mycobacterium
tuberculosis) 		PF02502
(LacAB_rpiB) 		4 PHE A 127
ILE A 108
GLN A 106
ARG A 100
 None
 1.39A 5jm4A-2vvqA:
undetectable		 5jm4A-2vvqA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wgr GLUTATHIONE
PEROXIDASE

(Schistosoma
mansoni) 		PF00255
(GSHPx) 		4 PHE A 117
ILE A  11
GLN A 122
ARG A 121
 None
 1.23A 5jm4A-2wgrA:
undetectable		 5jm4A-2wgrA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a1t IRON(II) TRANSPORT
PROTEIN B

(Thermotoga
maritima) 		PF02421
(FeoB_N) 		4 PHE A 156
ILE A 141
MET A 128
ARG A 143
 None
 1.12A 5jm4A-3a1tA:
undetectable		 5jm4A-3a1tA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a1w IRON(II) TRANSPORT
PROTEIN B

(Thermotoga
maritima) 		PF02421
(FeoB_N) 		4 PHE A 156
ILE A 141
MET A 128
ARG A 143
 None
 1.12A 5jm4A-3a1wA:
undetectable		 5jm4A-3a1wA:
23.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3axy 14-3-3-LIKE PROTEIN
GF14-C

(Oryza sativa) 		PF00244
(14-3-3) 		4 PHE C 200
ILE C 204
MET C 222
GLN C 223
 None
 0.49A 5jm4A-3axyC:
32.2		 5jm4A-3axyC:
65.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dmk DOWN SYNDROME CELL
ADHESION MOLECULE
(DSCAM) ISOFORM
1.30.30, N-TERMINAL
EIGHT IG DOMAINS

(Drosophila
melanogaster) 		PF07679
(I-set)
PF13927
(Ig_3) 		4 PHE A  63
ILE A  24
GLN A  78
ARG A  53
 None
 0.98A 5jm4A-3dmkA:
undetectable		 5jm4A-3dmkA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fq8 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE

(Synechococcus
elongatus) 		PF00202
(Aminotran_3) 		4 PHE A1220
ILE A1214
MET A1362
GLN A1358
 None
 1.41A 5jm4A-3fq8A:
undetectable		 5jm4A-3fq8A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gb0 PEPTIDASE T

(Bacillus cereus) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 PHE A  11
ILE A  96
MET A  12
GLN A  16
 None
 1.47A 5jm4A-3gb0A:
undetectable		 5jm4A-3gb0A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF00233
(PDEase_I)
PF01590
(GAF)
PF13185
(GAF_2) 		4 PHE A 731
ILE A 735
MET A 761
ARG A 762
 None
 0.82A 5jm4A-3ibjA:
3.4		 5jm4A-3ibjA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jwo HIV-1 GP120 ENVELOPE
GLYCOPROTEIN

(Homo sapiens) 		PF00516
(GP120) 		4 PHE A 468
ILE A 359
GLN A 352
ARG A 456
 None
 0.80A 5jm4A-3jwoA:
undetectable		 5jm4A-3jwoA:
18.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3m51 14-3-3-LIKE PROTEIN
C

(Nicotiana
tabacum) 		PF00244
(14-3-3) 		4 PHE A 205
ILE A 209
MET A 227
GLN A 228
 None
 0.43A 5jm4A-3m51A:
30.9		 5jm4A-3m51A:
64.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oq2 CRISPR-ASSOCIATED
PROTEIN CAS2

(Desulfovibrio
vulgaris) 		PF09827
(CRISPR_Cas2) 		4 PHE A  45
ILE A  29
GLN A  34
ARG A  39
 None
None
None
SO4  A 107 (-3.0A)
 1.35A 5jm4A-3oq2A:
undetectable		 5jm4A-3oq2A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qkw NUCLEOTIDE SUGAR
SYNTHETASE-LIKE
PROTEIN

(Streptococcus
parasanguinis) 		no annotation 4 PHE A 315
ILE A 309
MET A 153
ARG A 318
 None
 1.44A 5jm4A-3qkwA:
undetectable		 5jm4A-3qkwA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qqv GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Corynebacterium
glutamicum) 		PF00348
(polyprenyl_synt) 		4 PHE A  57
ILE A 106
GLN A 101
ARG A 117
 None
None
DMA  A 383 (-3.8A)
DMA  A 384 (-3.0A)
 1.33A 5jm4A-3qqvA:
5.4		 5jm4A-3qqvA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qty PHOSPHORIBOSYLAMINOI
MIDAZOLE (AIR)
SYNTHETASE

(Francisella
tularensis) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		4 PHE A 239
ILE A 310
MET A 320
GLN A 321
 None
 1.17A 5jm4A-3qtyA:
undetectable		 5jm4A-3qtyA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sun DNA POLYMERASE

(Escherichia
virus RB69) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 PHE A 654
ILE A 632
MET A 659
ARG A 658
 None
 1.23A 5jm4A-3sunA:
4.8		 5jm4A-3sunA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tgq HIV-1 YU2 GP120

(Human
immunodeficiency
virus 1) 		PF00516
(GP120) 		4 PHE A 468
ILE A 359
GLN A 352
ARG A 456
 None
 0.91A 5jm4A-3tgqA:
undetectable		 5jm4A-3tgqA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tni CYCLIN-T1

(Homo sapiens) 		PF00134
(Cyclin_N) 		4 PHE B 176
ILE B 255
MET B 177
ARG B 251
 None
 1.04A 5jm4A-3tniB:
2.4		 5jm4A-3tniB:
22.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ubw 14-3-3 PROTEIN
EPSILON

(Homo sapiens) 		PF00244
(14-3-3) 		4 PHE A 199
ILE A 203
MET A 221
ARG A 225
 None
 1.03A 5jm4A-3ubwA:
32.4		 5jm4A-3ubwA:
62.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wdj TYPE I PULLULANASE

(Anoxybacillus
sp. LM18-11) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		4 PHE A 634
ILE A 642
GLN A 561
ARG A 506
 None
 1.23A 5jm4A-3wdjA:
undetectable		 5jm4A-3wdjA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bom ENVELOPE
GLYCOPROTEIN B

(Human
alphaherpesvirus
1) 		PF00606
(Glycoprotein_B)
PF17416
(Glycoprot_B_PH1)
PF17417
(Glycoprot_B_PH2) 		4 PHE A 386
ILE A 450
MET A 375
ARG A 377
 None
 1.48A 5jm4A-4bomA:
undetectable		 5jm4A-4bomA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cso ORFY PROTEIN,
TRANSCRIPTION FACTOR

(Thermoproteus
tenax) 		no annotation 4 PHE A 122
ILE A  38
GLN A  33
ARG A  26
 None
 1.46A 5jm4A-4csoA:
undetectable		 5jm4A-4csoA:
22.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4dx0 14-3-3-LIKE PROTEIN
E

(Nicotiana
tabacum) 		PF00244
(14-3-3) 		4 PHE A 203
ILE A 207
MET A 225
ARG A 229
 None
 1.01A 5jm4A-4dx0A:
30.2		 5jm4A-4dx0A:
64.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4dx0 14-3-3-LIKE PROTEIN
E

(Nicotiana
tabacum) 		PF00244
(14-3-3) 		4 PHE A 203
ILE A 207
MET A 225
GLN A 226
 None
 0.41A 5jm4A-4dx0A:
30.2		 5jm4A-4dx0A:
64.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g59 M152 PROTEIN

(Murid
betaherpesvirus
1) 		PF11624
(M157) 		4 PHE C 169
ILE C  45
MET C  60
ARG C 165
 None
 1.26A 5jm4A-4g59C:
undetectable		 5jm4A-4g59C:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ht1 CHIMERIC ANTIBODY
FAB

(Oryctolagus
cuniculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 PHE H  68
ILE H  48
MET H  83
ARG H  67
 None
 1.11A 5jm4A-4ht1H:
undetectable		 5jm4A-4ht1H:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jpk GERMLINE-TARGETING
HIV-1 GP120
ENGINEERED OUTER
DOMAIN, EOD-GT6

(Human
immunodeficiency
virus 1) 		PF00516
(GP120) 		4 PHE A  38
ILE A 132
GLN A 126
ARG A  26
 None
 1.00A 5jm4A-4jpkA:
undetectable		 5jm4A-4jpkA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lej VICILIN

(Pinus
koraiensis) 		PF00190
(Cupin_1) 		4 PHE A 156
ILE A 137
GLN A 264
ARG A 148
 None
 1.49A 5jm4A-4lejA:
undetectable		 5jm4A-4lejA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lu4 PUTATIVE CELL
FILAMENTATION
PROTEIN

(Bartonella
quintana) 		PF02661
(Fic) 		4 PHE A 173
ILE A 204
GLN A 156
ARG A 157
 None
None
None
IOD  A 307 ( 4.9A)
 1.39A 5jm4A-4lu4A:
undetectable		 5jm4A-4lu4A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m1x UNCHARACTERIZED
PROTEIN
201PHI2-1P060

(Pseudomonas
phage 201phi2-1) 		no annotation 4 PHE A  66
ILE A  33
MET A  67
ARG A  70
 None
 1.48A 5jm4A-4m1xA:
undetectable		 5jm4A-4m1xA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nh0 CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata) 		PF01580
(FtsK_SpoIIIE) 		4 PHE A 908
ILE A 913
GLN A 903
ARG A 904
 None
 1.08A 5jm4A-4nh0A:
undetectable		 5jm4A-4nh0A:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qiw DNA-DIRECTED RNA
POLYMERASE

(Thermococcus
kodakarensis) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		4 PHE B 882
ILE B 742
GLN B 722
ARG B 996
 None
 1.31A 5jm4A-4qiwB:
undetectable		 5jm4A-4qiwB:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r2g SURFACE PROTEIN
GP160

(Human
immunodeficiency
virus 1) 		no annotation 4 PHE E 468
ILE E 359
GLN E 352
ARG E 456
 None
 0.99A 5jm4A-4r2gE:
undetectable		 5jm4A-4r2gE:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x9f DOWN SYNDROME CELL
ADHESION MOLECULE
ISOFORM 6.9

(Drosophila
melanogaster) 		PF07679
(I-set) 		4 PHE A  63
ILE A  24
GLN A  78
ARG A  53
 None
 1.06A 5jm4A-4x9fA:
undetectable		 5jm4A-4x9fA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ye4 HT593.1 GP120

(Human
immunodeficiency
virus) 		PF00516
(GP120) 		4 PHE G 470
ILE G 359
GLN G 352
ARG G 456
 None
 0.80A 5jm4A-4ye4G:
undetectable		 5jm4A-4ye4G:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z9n AMINO ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN

(Brucella ovis) 		PF00497
(SBP_bac_3) 		4 PHE A 289
ILE A 301
GLN A 315
ARG A 303
 None
 1.48A 5jm4A-4z9nA:
undetectable		 5jm4A-4z9nA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zlr BRAIN TUMOR PROTEIN

(Drosophila
melanogaster) 		PF01436
(NHL) 		4 PHE A 866
ILE A 853
GLN A 900
ARG A 864
 None
 1.28A 5jm4A-4zlrA:
undetectable		 5jm4A-4zlrA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5csu 4-ALPHA-GLUCANOTRANS
FERASE DPE1,
CHLOROPLASTIC/AMYLOP
LASTIC

(Arabidopsis
thaliana) 		PF02446
(Glyco_hydro_77) 		4 ILE A 418
MET A 441
GLN A 465
ARG A 433
 None
 1.47A 5jm4A-5csuA:
undetectable		 5jm4A-5csuA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ctr SQUAMOUS CELL
CARCINOMA ANTIGEN
RECOGNIZED BY
T-CELLS 3

(Homo sapiens) 		no annotation 4 PHE A 333
ILE A 329
GLN A 352
ARG A 349
 None
 0.83A 5jm4A-5ctrA:
7.7		 5jm4A-5ctrA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fqd DNA DAMAGE-BINDING
PROTEIN 1

(Homo sapiens) 		PF03178
(CPSF_A)
PF10433
(MMS1_N) 		4 PHE A1097
ILE A1130
MET A1105
GLN A1106
 None
 1.32A 5jm4A-5fqdA:
undetectable		 5jm4A-5fqdA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gpy GENERAL
TRANSCRIPTION FACTOR
IIE SUBUNIT 1

(Homo sapiens) 		PF02002
(TFIIE_alpha)
PF08271
(TF_Zn_Ribbon) 		4 PHE A 180
ILE A 184
MET A 110
ARG A 111
 None
 1.11A 5jm4A-5gpyA:
2.6		 5jm4A-5gpyA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gs0 TOLL-LIKE RECEPTOR 3

(Homo sapiens) 		PF13516
(LRR_6)
PF13855
(LRR_8) 		4 ILE A 668
MET A 642
GLN A 618
ARG A 643
 None
 1.47A 5jm4A-5gs0A:
undetectable		 5jm4A-5gs0A:
16.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5iqp 14-3-3 PROTEIN THETA

(Homo sapiens) 		PF00244
(14-3-3) 		4 PHE A 196
ILE A 200
MET A 218
GLN A 219
 None
 1.05A 5jm4A-5iqpA:
33.1		 5jm4A-5iqpA:
81.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5iqp 14-3-3 PROTEIN THETA

(Homo sapiens) 		PF00244
(14-3-3) 		4 PHE A 196
MET A 218
GLN A 219
ARG A 222
 None
 1.48A 5jm4A-5iqpA:
33.1		 5jm4A-5iqpA:
81.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j1d PHOSPHATE BINDING
PROTEIN

(Stenotrophomonas
maltophilia) 		PF12849
(PBP_like_2) 		4 PHE A 351
ILE A  92
GLN A 295
ARG A 350
 None
 1.35A 5jm4A-5j1dA:
undetectable		 5jm4A-5j1dA:
19.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5lu2 14-3-3 PROTEIN SIGMA

(Homo sapiens) 		PF00244
(14-3-3) 		4 PHE A 198
MET A 220
GLN A 221
ARG A 224
 None
 0.97A 5jm4A-5lu2A:
32.9		 5jm4A-5lu2A:
73.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n6n PROTEIN BMH1

(Saccharomyces
cerevisiae) 		no annotation 4 PHE A 201
MET A 223
GLN A 224
ARG A 227
 None
 1.00A 5jm4A-5n6nA:
32.1		 5jm4A-5n6nA:
67.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5na7 PUTATIVE
DIPEPTIDYL-PEPTIDASE
III

(Bacteroides
thetaiotaomicron) 		no annotation 4 PHE A 511
ILE A 540
GLN A 519
ARG A 537
 None
 1.40A 5jm4A-5na7A:
undetectable		 5jm4A-5na7A:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xhq APOLIPOPROTEIN
N-ACYLTRANSFERASE

(Escherichia
coli) 		PF00795
(CN_hydrolase) 		4 PHE A 426
ILE A 448
GLN A 427
ARG A 430
 None
 1.35A 5jm4A-5xhqA:
undetectable		 5jm4A-5xhqA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xu5 ENDO-1,4-BETA-MANNAN
ASE

(Rhizopus
microsporus) 		no annotation 4 PHE B  58
ILE B  57
GLN B  98
ARG B  97
 None
 1.39A 5jm4A-5xu5B:
undetectable		 5jm4A-5xu5B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6df3 -

(-) 		no annotation 4 PHE C  54
ILE C 147
MET C 200
GLN C 201
 GOL  C 302 (-4.3A)
None
GOL  C 302 (-4.7A)
GOL  C 302 (-3.1A)
 1.34A 5jm4A-6df3C:
undetectable		 5jm4A-6df3C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f0x MAD2L1-BINDING
PROTEIN

(Homo sapiens) 		no annotation 4 ILE P 152
MET P  81
GLN P  86
ARG P  84
 None
 1.29A 5jm4A-6f0xP:
undetectable		 5jm4A-6f0xP:
undetectable