SIMILAR PATTERNS OF AMINO ACIDS FOR 5JLC_A_1YNA602_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a0e XYLOSE ISOMERASE

(Thermotoga
neapolitana) 		PF01261
(AP_endonuc_2) 		4 GLY A 226
THR A 225
GLY A 152
LEU A 212
 None
 0.71A 5jlcA-1a0eA:
0.0		 5jlcA-1a0eA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bxn PROTEIN (RIBULOSE
BISPHOSPHATE
CARBOXYLASE LARGE
CHAIN)

(Cupriavidus
necator) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 GLY A 248
THR A 249
GLY A 310
LEU A 272
 None
 0.56A 5jlcA-1bxnA:
0.0		 5jlcA-1bxnA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e5d RUBREDOXIN:OXYGEN
OXIDOREDUCTASE

(Desulfovibrio
gigas) 		PF00258
(Flavodoxin_1)
PF00753
(Lactamase_B) 		4 GLY A 361
THR A 360
GLY A  25
LEU A 332
 None
 0.67A 5jlcA-1e5dA:
0.4		 5jlcA-1e5dA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6v METHYL-COENZYME M
REDUCTASE I ALPHA
SUBUNIT
METHYL-COENZYME M
REDUCTASE I BETA
SUBUNIT
METHYL-COENZYME M
REDUCTASE I GAMMA
SUBUNIT

(Methanopyrus
kandleri) 		PF02240
(MCR_gamma)
PF02241
(MCR_beta)
PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N)
PF02783
(MCR_beta_N) 		4 GLY B 344
THR B 343
GLY A 384
LEU C 235
 None
 0.81A 5jlcA-1e6vB:
0.8		 5jlcA-1e6vB:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6z CHITINASE B

(Serratia
marcescens) 		PF00704
(Glyco_hydro_18) 		4 TYR A  10
GLY A   9
GLY A 279
LEU A 211
 NGO  A 502 (-3.2A)
None
None
None
 0.71A 5jlcA-1e6zA:
0.0		 5jlcA-1e6zA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g8k ARSENITE OXIDASE

(Alcaligenes
faecalis) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		4 GLY A 114
THR A 113
GLY A 172
LEU A 515
 None
None
None
MGD  A5001 (-4.0A)
 0.87A 5jlcA-1g8kA:
0.0		 5jlcA-1g8kA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l2q MONOMETHYLAMINE
METHYLTRANSFERASE

(Methanosarcina
barkeri) 		PF05369
(MtmB) 		4 GLY A 380
THR A 379
GLY A 395
LEU A 364
 None
 0.69A 5jlcA-1l2qA:
0.0		 5jlcA-1l2qA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
METHANOL
DEHYDROGENASE
SUBUNIT 2

(Paracoccus
denitrificans) 		PF01011
(PQQ)
PF02315
(MDH)
PF13360
(PQQ_2) 		4 TYR B   1
GLY B   3
THR B   4
GLY A 182
 None
 0.73A 5jlcA-1lrwB:
undetectable		 5jlcA-1lrwB:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n7d LOW-DENSITY
LIPOPROTEIN RECEPTOR

(Homo sapiens) 		PF00057
(Ldl_recept_a)
PF00058
(Ldl_recept_b)
PF07645
(EGF_CA)
PF14670
(FXa_inhibition) 		4 GLY A 516
THR A 517
GLY A 552
LEU A 534
 None
 0.87A 5jlcA-1n7dA:
undetectable		 5jlcA-1n7dA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1odf HYPOTHETICAL 33.3
KDA PROTEIN IN
ADE3-SER2 INTERGENIC
REGION

(Saccharomyces
cerevisiae) 		no annotation 4 GLY A 146
THR A 145
GLY A 164
LEU A 107
 None
 0.81A 5jlcA-1odfA:
undetectable		 5jlcA-1odfA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pbk FKBP25

(Homo sapiens) 		PF00254
(FKBP_C) 		4 GLY A 142
THR A 143
GLY A 119
LEU A 190
 None
 0.91A 5jlcA-1pbkA:
undetectable		 5jlcA-1pbkA:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r82 GLYCOPROTEIN-FUCOSYL
GALACTOSIDE
ALPHA-GALACTOSYLTRAN
SFERASE

(Homo sapiens) 		PF03414
(Glyco_transf_6) 		4 GLY A 167
THR A 166
GLY A 230
LEU A 118
 None
 0.93A 5jlcA-1r82A:
undetectable		 5jlcA-1r82A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w6s METHANOL
DEHYDROGENASE
SUBUNIT 1
METHANOL
DEHYDROGENASE
SUBUNIT 2

(Methylobacterium
extorquens) 		PF01011
(PQQ)
PF02315
(MDH)
PF13360
(PQQ_2) 		4 TYR B1001
GLY B1003
THR B1004
GLY A 182
 None
 0.65A 5jlcA-1w6sB:
undetectable		 5jlcA-1w6sB:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xc3 PUTATIVE
FRUCTOKINASE

(Bacillus
subtilis) 		PF00480
(ROK) 		4 TYR A  70
GLY A  71
THR A  72
LEU A 142
 None
 0.78A 5jlcA-1xc3A:
undetectable		 5jlcA-1xc3A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xez HEMOLYSIN

(Vibrio cholerae) 		PF07968
(Leukocidin)
PF12563
(Hemolysin_N)
PF16458
(Beta-prism_lec) 		4 TYR A 666
GLY A 641
GLY A 628
LEU A 662
 None
 0.91A 5jlcA-1xezA:
undetectable		 5jlcA-1xezA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xfg GLUCOSAMINE--FRUCTOS
E-6-PHOSPHATE
AMINOTRANSFERASE
[ISOMERIZING]

(Escherichia
coli) 		PF13522
(GATase_6) 		4 GLY A 226
THR A 225
GLY A  68
LEU A 141
 None
 0.83A 5jlcA-1xfgA:
undetectable		 5jlcA-1xfgA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yzy HYPOTHETICAL PROTEIN
HI1011

(Haemophilus
influenzae) 		PF07005
(DUF1537)
PF17042
(DUF1357_C) 		4 GLY A 236
THR A 237
GLY A 354
LEU A 382
 None
 0.66A 5jlcA-1yzyA:
undetectable		 5jlcA-1yzyA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c1w ENDOU PROTEIN

(Xenopus laevis) 		PF09412
(XendoU) 		4 TYR A  43
GLY A  42
GLY A 232
LEU A  37
 None
 0.80A 5jlcA-2c1wA:
undetectable		 5jlcA-2c1wA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cwl MANGANESE-FREE
PSEUDOCATALASE

(Thermus
thermophilus) 		PF05067
(Mn_catalase) 		4 TYR A 224
GLY A 179
GLY A 275
LEU A   8
 None
 0.86A 5jlcA-2cwlA:
undetectable		 5jlcA-2cwlA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d0v METHANOL
DEHYDROGENASE LARGE
SUBUNIT
METHANOL
DEHYDROGENASE SMALL
SUBUNIT

(Hyphomicrobium
denitrificans) 		PF01011
(PQQ)
PF02315
(MDH)
PF13360
(PQQ_2) 		4 TYR B   1
GLY B   3
THR B   4
GLY A 182
 None
 0.79A 5jlcA-2d0vB:
undetectable		 5jlcA-2d0vB:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ejw HOMOSERINE
DEHYDROGENASE

(Thermus
thermophilus) 		PF00742
(Homoserine_dh)
PF03447
(NAD_binding_3) 		4 GLY A 151
THR A 152
GLY A 325
LEU A 196
 NO3  A2602 (-3.2A)
NO3  A2602 (-4.4A)
None
None
 0.87A 5jlcA-2ejwA:
undetectable		 5jlcA-2ejwA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fp3 CASPASE NC

(Drosophila
melanogaster) 		PF00656
(Peptidase_C14) 		4 TYR A 389
THR A 429
GLY A 185
LEU A 368
 None
 0.93A 5jlcA-2fp3A:
undetectable		 5jlcA-2fp3A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fsr ACETYLTRANSFERASE

(Agrobacterium
fabrum) 		PF13302
(Acetyltransf_3) 		4 TYR A 165
GLY A 147
THR A 148
GLY A 100
 None
 0.81A 5jlcA-2fsrA:
undetectable		 5jlcA-2fsrA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gu1 ZINC PEPTIDASE

(Vibrio cholerae) 		PF01551
(Peptidase_M23)
PF04225
(OapA) 		4 GLY A 309
THR A 308
GLY A 295
LEU A 281
 None
 0.79A 5jlcA-2gu1A:
undetectable		 5jlcA-2gu1A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hdi COLICIN I RECEPTOR
COLICIN-IA

(Escherichia
coli) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug)
PF11504
(Colicin_Ia) 		4 GLY A 352
THR A 353
GLY B 310
LEU A 424
 None
 0.92A 5jlcA-2hdiA:
undetectable		 5jlcA-2hdiA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hrz NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE

(Agrobacterium
fabrum) 		PF01370
(Epimerase) 		4 TYR A 159
GLY A 160
THR A 161
GLY A 312
 None
 0.70A 5jlcA-2hrzA:
undetectable		 5jlcA-2hrzA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j6l ALDEHYDE
DEHYDROGENASE FAMILY
7 MEMBER A1

(Homo sapiens) 		PF00171
(Aldedh) 		4 GLY A 231
THR A 232
GLY A 482
LEU A 242
 NAI  A1501 (-3.4A)
NAI  A1501 (-4.3A)
None
None
 0.85A 5jlcA-2j6lA:
undetectable		 5jlcA-2j6lA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kh2 SCFV

(Mus musculus) 		PF07686
(V-set) 		4 TYR B 224
GLY B 241
THR B 242
GLY B 116
 None
 0.84A 5jlcA-2kh2B:
undetectable		 5jlcA-2kh2B:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pw6 UNCHARACTERIZED
PROTEIN YGID

(Escherichia
coli) 		PF02900
(LigB) 		4 GLY A 225
THR A 226
GLY A 247
LEU A 238
 None
 0.91A 5jlcA-2pw6A:
undetectable		 5jlcA-2pw6A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uvf EXOPOLYGALACTURONASE

(Yersinia
enterocolitica) 		PF00295
(Glyco_hydro_28)
PF12708
(Pectate_lyase_3) 		4 TYR A 230
GLY A 229
GLY A 265
LEU A 333
 None
 0.86A 5jlcA-2uvfA:
undetectable		 5jlcA-2uvfA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v4j SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT ALPHA
SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT BETA

(Desulfovibrio
vulgaris) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		4 GLY A 143
THR A 144
GLY B 125
LEU A  51
 None
 0.68A 5jlcA-2v4jA:
undetectable		 5jlcA-2v4jA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v5n CATION-INDEPENDENT
MANNOSE-6-PHOSPHATE
RECEPTOR

(Homo sapiens) 		PF00878
(CIMR) 		4 TYR A1592
GLY A1564
GLY A1619
LEU A1532
 None
 0.91A 5jlcA-2v5nA:
undetectable		 5jlcA-2v5nA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vqa SLL1358 PROTEIN

(Synechocystis
sp. PCC 6803) 		PF00190
(Cupin_1) 		4 GLY A 166
THR A 167
GLY A 297
LEU A 160
 None
 0.69A 5jlcA-2vqaA:
undetectable		 5jlcA-2vqaA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2waw MOBA RELATE PROTEIN

(Mycobacterium
sp. DSM 3803) 		PF12804
(NTP_transf_3) 		4 TYR A  15
GLY A  80
GLY A 165
LEU A 152
 CSO  A  81 (-4.2A)
CSO  A  81 (-2.4A)
None
None
 0.68A 5jlcA-2wawA:
undetectable		 5jlcA-2wawA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xdq LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT N

(Thermosynechococcus
elongatus) 		PF00148
(Oxidored_nitro) 		4 TYR A 355
THR A 257
GLY A 221
LEU A 201
 None
 0.88A 5jlcA-2xdqA:
undetectable		 5jlcA-2xdqA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsj SULFITE REDUCTASE
ALPHA SUBUNIT
SULFITE REDUCTASE
BETA SUBUNIT

(Desulfomicrobium
norvegicum) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr)
PF12838
(Fer4_7) 		4 GLY A 143
THR A 144
GLY B 125
LEU A  51
 None
 0.71A 5jlcA-2xsjA:
undetectable		 5jlcA-2xsjA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yfn ALPHA-GALACTOSIDASE-
SUCROSE KINASE AGASK

([Ruminococcus]
gnavus) 		PF02065
(Melibiase)
PF16874
(Glyco_hydro_36C)
PF16875
(Glyco_hydro_36N) 		4 TYR A 552
GLY A 553
THR A 554
GLY A 188
 None
None
None
GOL  A1722 ( 4.0A)
 0.70A 5jlcA-2yfnA:
undetectable		 5jlcA-2yfnA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z6g B-CATENIN

(Danio rerio) 		PF00514
(Arm) 		4 GLY A 574
THR A 573
GLY A 442
LEU A 516
 None
 0.92A 5jlcA-2z6gA:
undetectable		 5jlcA-2z6gA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z6v PUTATIVE
UNCHARACTERIZED
PROTEIN

(Mycobacterium
avium) 		PF13469
(Sulfotransfer_3) 		4 TYR A 368
GLY A 260
THR A 259
LEU A 268
 None
 0.93A 5jlcA-2z6vA:
undetectable		 5jlcA-2z6vA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zxq ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE

(Bifidobacterium
longum) 		PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C) 		4 GLY A1404
THR A1403
GLY A1281
LEU A1271
 None
 0.77A 5jlcA-2zxqA:
undetectable		 5jlcA-2zxqA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3akf PUTATIVE SECRETED
ALPHA
L-ARABINOFURANOSIDAS
E II

(Streptomyces
avermitilis) 		PF04616
(Glyco_hydro_43)
PF05270
(AbfB) 		4 GLY A  72
THR A  96
GLY A 259
LEU A 134
 None
 0.91A 5jlcA-3akfA:
undetectable		 5jlcA-3akfA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fdj DEGV FAMILY PROTEIN

([Eubacterium]
eligens) 		PF02645
(DegV) 		4 GLY A 116
THR A 115
GLY A 133
LEU A   3
 None
P6G  A 276 ( 3.7A)
None
None
 0.80A 5jlcA-3fdjA:
undetectable		 5jlcA-3fdjA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fpz THIAZOLE
BIOSYNTHETIC ENZYME

(Saccharomyces
cerevisiae) 		PF01946
(Thi4) 		4 GLY A 182
THR A 179
GLY A  72
LEU A 173
 None
None
AHZ  A1100 (-3.3A)
None
 0.78A 5jlcA-3fpzA:
undetectable		 5jlcA-3fpzA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fru BETA-2-MICROGLOBULIN
NEONATAL FC RECEPTOR

(Rattus
norvegicus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		4 GLY A 229
THR A 228
GLY B  43
LEU B  23
 None
 0.88A 5jlcA-3fruA:
undetectable		 5jlcA-3fruA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i4y CATECHOL
1,2-DIOXYGENASE

(Rhodococcus
opacus) 		PF00775
(Dioxygenase_C)
PF04444
(Dioxygenase_N) 		4 GLY A 176
THR A 177
GLY A 241
LEU A 132
 None
 0.83A 5jlcA-3i4yA:
undetectable		 5jlcA-3i4yA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k3q LLAMA AA1 VHH DOMAIN

(Lama glama) 		PF07686
(V-set) 		4 GLY A  13
THR A  14
GLY A 122
LEU A  95
 None
 0.86A 5jlcA-3k3qA:
undetectable		 5jlcA-3k3qA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kw7 LACCASE B

(Trametes sp.
AH28-2) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 GLY A 369
THR A 368
GLY A 434
LEU A 454
 None
 0.87A 5jlcA-3kw7A:
undetectable		 5jlcA-3kw7A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lmd GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Corynebacterium
glutamicum) 		PF00348
(polyprenyl_synt) 		4 GLY A 173
THR A 172
GLY A  72
LEU A 110
 None
 0.92A 5jlcA-3lmdA:
1.2		 5jlcA-3lmdA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o75 FRUCTOSE TRANSPORT
SYSTEM REPRESSOR
FRUR

(Pseudomonas
putida) 		PF00532
(Peripla_BP_1) 		4 GLY A 210
THR A 209
GLY A 274
LEU A 184
 None
None
F1X  A   1 (-3.1A)
None
 0.84A 5jlcA-3o75A:
1.1		 5jlcA-3o75A:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sqz PUTATIVE
HYDROXYMETHYLGLUTARY
L-COA SYNTHASE

(Streptococcus
mutans) 		PF00195
(Chal_sti_synt_N)
PF08540
(HMG_CoA_synt_C) 		4 GLY A 318
THR A 317
GLY A  57
LEU A 287
 None
 0.90A 5jlcA-3sqzA:
undetectable		 5jlcA-3sqzA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w4q BETA-LACTAMASE

(Burkholderia
multivorans) 		PF13354
(Beta-lactamase2) 		4 GLY A  55
THR A  54
GLY A 236
LEU A 190
 None
 0.92A 5jlcA-3w4qA:
undetectable		 5jlcA-3w4qA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zo9 TREHALOSE
SYNTHASE/AMYLASE
TRES

(Mycolicibacterium
smegmatis) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		4 GLY A 106
THR A 107
GLY A 419
LEU A  45
 None
CL  A1591 ( 4.7A)
None
CL  A1590 (-4.1A)
 0.91A 5jlcA-3zo9A:
undetectable		 5jlcA-3zo9A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyy IRON-SULFUR CLUSTER
BINDING PROTEIN

(Carboxydothermus
hydrogenoformans) 		PF00111
(Fer2)
PF14574
(DUF4445) 		4 GLY X 354
THR X 299
GLY X 228
LEU X 575
 None
 0.89A 5jlcA-3zyyX:
undetectable		 5jlcA-3zyyX:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ag4 MONOCLONAL ANTIBODY
3E3 HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 TYR H  91
GLY H 106
THR H 107
GLY H 162
 None
 0.88A 5jlcA-4ag4H:
undetectable		 5jlcA-4ag4H:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ap3 STEROID
MONOOXYGENASE

(Rhodococcus
rhodochrous) 		PF00743
(FMO-like) 		4 GLY A 375
THR A 374
GLY A  67
LEU A 217
 None
 0.89A 5jlcA-4ap3A:
undetectable		 5jlcA-4ap3A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c1n IRON-SULFUR CLUSTER
BINDING PROTEIN

(Carboxydothermus
hydrogenoformans) 		PF14574
(DUF4445) 		4 GLY I 354
THR I 299
GLY I 228
LEU I 575
 None
 0.84A 5jlcA-4c1nI:
undetectable		 5jlcA-4c1nI:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cok PYRUVATE
DECARBOXYLASE

(Gluconacetobacter
diazotrophicus) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 TYR A 347
GLY A 259
THR A 241
GLY A 435
 None
None
None
TPP  A 600 (-3.4A)
 0.84A 5jlcA-4cokA:
undetectable		 5jlcA-4cokA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d8o ANKYRIN-2

(Homo sapiens) 		PF00531
(Death)
PF00791
(ZU5) 		4 GLY A1234
THR A1235
GLY A1135
LEU A1189
 None
 0.90A 5jlcA-4d8oA:
undetectable		 5jlcA-4d8oA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4doi CHALCONE--FLAVONONE
ISOMERASE 1

(Arabidopsis
thaliana) 		PF02431
(Chalcone) 		4 GLY A 185
THR A 184
GLY A 207
LEU A 165
 None
 0.79A 5jlcA-4doiA:
undetectable		 5jlcA-4doiA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dq8 ACETATE KINASE

(Mycobacterium
marinum) 		PF00871
(Acetate_kinase) 		4 GLY A 170
THR A 171
GLY A 339
LEU A 196
 None
 0.93A 5jlcA-4dq8A:
undetectable		 5jlcA-4dq8A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e4g METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF00171
(Aldedh) 		4 GLY A  31
THR A  32
GLY A 273
LEU A  85
 None
 0.85A 5jlcA-4e4gA:
undetectable		 5jlcA-4e4gA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hbc ANTIGEN BINDING
FRAGMENT,
IMMUNOGLOBULIN IGG -
HEAVY CHAIN
ANTIGEN BINDING
FRAGMENT,
IMMUNOGLOBULIN IGG -
LIGHT CHAIN

(Oryctolagus
cuniculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 TYR L  87
GLY L 103
THR L 104
GLY H 176
 None
 0.92A 5jlcA-4hbcL:
undetectable		 5jlcA-4hbcL:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jy4 PGT121 HEAVY CHAIN
PGT121 LIGHT CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 TYR A  87
GLY A 101
THR A 102
GLY B 172
 None
 0.68A 5jlcA-4jy4A:
undetectable		 5jlcA-4jy4A:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kvf RHAMNOSE ABC
TRANSPORTER,
PERIPLASMIC
RHAMNOSE-BINDING
PROTEIN

(Kribbella
flavida) 		PF13407
(Peripla_BP_4) 		4 GLY A 323
THR A 322
GLY A  97
LEU A 135
 None
 0.79A 5jlcA-4kvfA:
undetectable		 5jlcA-4kvfA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o5m ISOVALERYL-COA
DEHYDROGENASE

(Brucella suis) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 GLY A 350
THR A 349
GLY A 160
LEU A 358
 None
 0.88A 5jlcA-4o5mA:
undetectable		 5jlcA-4o5mA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o9x TCDB2, TCCC3

(Photorhabdus
luminescens) 		PF03534
(SpvB)
PF12255
(TcdB_toxin_midC)
PF12256
(TcdB_toxin_midN) 		4 GLY A 502
THR A 518
GLY A 621
LEU A 558
 None
 0.78A 5jlcA-4o9xA:
undetectable		 5jlcA-4o9xA:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qiw DNA-DIRECTED RNA
POLYMERASE

(Thermococcus
kodakarensis) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		4 GLY B 460
THR B 461
GLY B 951
LEU B 650
 None
 0.91A 5jlcA-4qiwB:
undetectable		 5jlcA-4qiwB:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rav SINGLE-CHAIN FV, VH
SINGLE-CHAIN FV, VL

(Homo sapiens) 		PF07686
(V-set) 		4 TYR B 216
GLY B 230
THR B 231
GLY A 118
 None
 0.88A 5jlcA-4ravB:
undetectable		 5jlcA-4ravB:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s12 N-ACETYLMURAMIC ACID
6-PHOSPHATE ETHERASE

(Yersinia
enterocolitica) 		PF01380
(SIS) 		4 TYR A 290
GLY A 289
GLY A  77
LEU A  59
 None
 0.87A 5jlcA-4s12A:
0.7		 5jlcA-4s12A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y63 HISTO-BLOOD GROUP
ABO SYSTEM
TRANSFERASE

(Homo sapiens) 		PF03414
(Glyco_transf_6) 		4 GLY A 167
THR A 166
GLY A 230
LEU A 118
 None
 0.92A 5jlcA-4y63A:
undetectable		 5jlcA-4y63A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ydj HEAVY CHAIN OF
ANTIBODY 44-VRC13.01
LIGHT CHAIN OF
ANTIBODY 44-VRC13.01

(Homo sapiens) 		no annotation 4 TYR L  87
GLY L 101
THR L 102
GLY H 174
 None
 0.92A 5jlcA-4ydjL:
undetectable		 5jlcA-4ydjL:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yjf D-AMINO-ACID OXIDASE

(Sus scrofa) 		PF01266
(DAO) 		4 GLY B 240
THR B 241
GLY B 113
LEU B  51
 None
 0.87A 5jlcA-4yjfB:
undetectable		 5jlcA-4yjfB:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z0b ANTIBODY HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 TYR H  95
GLY H 115
THR H 116
GLY H 170
 None
 0.92A 5jlcA-4z0bH:
undetectable		 5jlcA-4z0bH:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zzq CELLULOSE
1,4-BETA-CELLOBIOSID
ASE

(Dictyostelium
discoideum) 		PF00840
(Glyco_hydro_7) 		4 GLY A 152
THR A 168
GLY A 430
LEU A 145
 None
 0.91A 5jlcA-4zzqA:
undetectable		 5jlcA-4zzqA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ap9 LIPASE

(Thermomyces
lanuginosus) 		PF01764
(Lipase_3)
PF03893
(Lipase3_N) 		4 GLY A 191
THR A 192
GLY A  59
LEU A  78
 None
GOL  A 401 (-3.8A)
None
None
 0.91A 5jlcA-5ap9A:
undetectable		 5jlcA-5ap9A:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5awn HEAVY CHAIN OF
3BC176 FAB
LIGHT CHAIN OF
3BC176 FAB

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 TYR L  87
GLY L 101
THR L 102
GLY H 174
 None
 0.80A 5jlcA-5awnL:
undetectable		 5jlcA-5awnL:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b3v BILIVERDIN REDUCTASE

(Synechocystis
sp. PCC 6803) 		no annotation 4 GLY B 264
THR B 263
GLY B 228
LEU B 144
 None
 0.91A 5jlcA-5b3vB:
undetectable		 5jlcA-5b3vB:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5equ SNON,SNON

(Streptomyces
nogalater) 		PF05721
(PhyH) 		4 GLY A 142
THR A 143
GLY A  65
LEU A 246
 None
 0.93A 5jlcA-5equA:
undetectable		 5jlcA-5equA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fn4 NICASTRIN

(Homo sapiens) 		PF05450
(Nicastrin) 		4 GLY A 576
THR A 577
GLY A 549
LEU A 538
 None
 0.81A 5jlcA-5fn4A:
0.7		 5jlcA-5fn4A:
21.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fsa CYP51 VARIANT1

(Candida
albicans) 		PF00067
(p450) 		4 TYR A  64
GLY A  65
GLY A 303
LEU A 376
 None
X2N  A 590 ( 4.0A)
X2N  A 590 ( 4.8A)
X2N  A 590 (-4.3A)
 0.47A 5jlcA-5fsaA:
54.7		 5jlcA-5fsaA:
62.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5giu PROLINE DIPEPTIDASE

(Deinococcus
radiodurans) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		4 TYR A 218
GLY A 217
GLY A  90
LEU A  30
 None
 0.83A 5jlcA-5giuA:
undetectable		 5jlcA-5giuA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5glg FUMARATE REDUCTASE 2

(Saccharomyces
cerevisiae) 		PF00890
(FAD_binding_2) 		4 GLY A 148
THR A 325
GLY A 159
LEU A 306
 None
 0.90A 5jlcA-5glgA:
undetectable		 5jlcA-5glgA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i2h O-METHYLTRANSFERASE
FAMILY 2

(Planctopirus
limnophila) 		PF00891
(Methyltransf_2)
PF16864
(Dimerisation2) 		4 GLY A 307
THR A 306
GLY A 202
LEU A 318
 None
 0.73A 5jlcA-5i2hA:
undetectable		 5jlcA-5i2hA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j13 ANTI-TSLP
FAB-FRAGMENT, HEAVY
CHAIN
ANTI-TSLP
FAB-FRAGMENT, LIGHT
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 TYR B  89
GLY B 105
THR B 106
GLY C 186
 None
 0.85A 5jlcA-5j13B:
undetectable		 5jlcA-5j13B:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jh8 PROBABLE CHITINASE

(Chromobacterium
violaceum) 		PF00704
(Glyco_hydro_18) 		4 TYR A 219
GLY A 218
THR A 271
GLY A  63
 6KY  A 504 (-3.7A)
None
None
None
 0.72A 5jlcA-5jh8A:
undetectable		 5jlcA-5jh8A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jpn COMPLEMENT C4-A

(Homo sapiens) 		PF01759
(NTR)
PF07677
(A2M_recep) 		4 TYR C1737
GLY C1738
THR C1739
GLY C1697
 None
 0.62A 5jlcA-5jpnC:
undetectable		 5jlcA-5jpnC:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mdx CHLOROPHYLL A-B
BINDING PROTEIN
CP26, CHLOROPLASTIC
PHOTOSYSTEM II CP43
REACTION CENTER
PROTEIN

(Arabidopsis
thaliana) 		PF00421
(PSII)
PF00504
(Chloroa_b-bind) 		4 TYR C 131
GLY C 136
GLY S  87
LEU S  76
 CLA  S 301 (-4.0A)
None
None
None
 0.88A 5jlcA-5mdxC:
undetectable		 5jlcA-5mdxC:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mrw POTASSIUM-TRANSPORTI
NG ATPASE
ATP-BINDING SUBUNIT

(Escherichia
coli) 		PF00122
(E1-E2_ATPase)
PF00702
(Hydrolase) 		4 GLY B 519
THR B 520
GLY B 510
LEU B 305
 None
 0.74A 5jlcA-5mrwB:
undetectable		 5jlcA-5mrwB:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ncc FATTY ACID
PHOTODECARBOXYLASE

(Chlorella
variabilis) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		4 TYR A 515
GLY A 514
GLY A  90
LEU A 142
 None
None
FAD  A 701 (-3.4A)
None
 0.77A 5jlcA-5nccA:
0.4		 5jlcA-5nccA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nv3 RIBULOSE
BISPHOSPHATE
CARBOXYLASE LARGE
CHAIN

(Rhodobacter
sphaeroides) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 GLY A 247
THR A 248
GLY A 309
LEU A 271
 None
 0.76A 5jlcA-5nv3A:
undetectable		 5jlcA-5nv3A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oko PHOSPHATIDYLINOSITOL
3,4,5-TRISPHOSPHATE
5-PHOSPHATASE 2

(Homo sapiens) 		PF03372
(Exo_endo_phos) 		4 TYR A 707
GLY A 723
THR A 724
GLY A 860
 None
 0.93A 5jlcA-5okoA:
undetectable		 5jlcA-5okoA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wnn PHOSPHATE-BINDING
PROTEIN PSTS

(Burkholderia
pseudomallei) 		PF12849
(PBP_like_2) 		4 GLY A 234
THR A 233
GLY A 107
LEU A 115
 None
 0.93A 5jlcA-5wnnA:
undetectable		 5jlcA-5wnnA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wp6 TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY M
MEMBER 4

(Homo sapiens) 		no annotation 4 TYR A 229
GLY A 187
GLY A 303
LEU A 142
 None
 0.86A 5jlcA-5wp6A:
undetectable		 5jlcA-5wp6A:
9.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xeo CYSTEINE SYNTHASE

(Fusobacterium
nucleatum) 		no annotation 4 TYR A 232
GLY A 178
THR A 177
LEU A 241
 None
PLP  A 401 (-3.3A)
PLP  A 401 (-2.8A)
None
 0.75A 5jlcA-5xeoA:
undetectable		 5jlcA-5xeoA:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xm3 GLUCOSE
DEHYDROGENASE
METHANOL
DEHYDROGENASE
[CYTOCHROME C]
SUBUNIT 2

(Methylophaga
aminisulfidivorans) 		no annotation 4 TYR B  25
GLY B  27
THR B  28
GLY A 213
 None
 0.77A 5jlcA-5xm3B:
undetectable		 5jlcA-5xm3B:
8.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zc3 -

(-) 		no annotation 4 GLY B 194
THR B 195
GLY B 178
LEU B 188
 None
 0.93A 5jlcA-5zc3B:
undetectable		 5jlcA-5zc3B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eq8 PERIPLASMIC
ALPHA-GALACTOSIDE-BI
NDING PROTEIN

(Agrobacterium
tumefaciens) 		no annotation 4 TYR D 294
GLY D 273
GLY D 631
LEU D 649
 None
 0.83A 5jlcA-6eq8D:
undetectable		 5jlcA-6eq8D:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fb3 TENEURIN-2

(Gallus gallus) 		no annotation 4 TYR A2010
GLY A2009
THR A1745
LEU A2704
 None
 0.91A 5jlcA-6fb3A:
undetectable		 5jlcA-6fb3A:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
8fab IGG1-LAMBDA HIL FAB
(HEAVY CHAIN)
IGG1-LAMBDA HIL FAB
(LIGHT CHAIN)

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 TYR A  86
GLY A 100
THR A 101
GLY B 182
 None
 0.90A 5jlcA-8fabA:
undetectable		 5jlcA-8fabA:
17.41