SIMILAR PATTERNS OF AMINO ACIDS FOR 5JLC_A_1YNA602

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bs0 PROTEIN
(8-AMINO-7-OXONANOAT
E SYNTHASE)

(Escherichia
coli) 		PF00155
(Aminotran_1_2) 		5 ALA A 134
ILE A  58
GLY A  51
THR A 365
HIS A 207
 None
 1.36A 5jlcA-1bs0A:
0.3		 5jlcA-1bs0A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d0n HORSE PLASMA
GELSOLIN

(Equus caballus) 		PF00626
(Gelsolin) 		5 TYR A 464
ILE A 448
PHE A 441
THR A 549
MET A 517
 None
 1.26A 5jlcA-1d0nA:
0.1		 5jlcA-1d0nA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d1t ALCOHOL
DEHYDROGENASE CLASS
IV SIGMA CHAIN

(Homo sapiens) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		6 ALA A 158
PHE A  21
ILE A  53
PHE A 146
THR A 370
THR A  70
 None
 1.38A 5jlcA-1d1tA:
undetectable		 5jlcA-1d1tA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i9z PHOSPHATIDYLINOSITOL
PHOSPHATE
PHOSPHATASE

(Schizosaccharomyces
pombe) 		PF03372
(Exo_endo_phos) 		5 PHE A 686
ILE A 660
TYR A 688
PHE A 695
HIS A 827
 None
 1.17A 5jlcA-1i9zA:
undetectable		 5jlcA-1i9zA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jmz AMINE DEHYDROGENASE

(Pseudomonas
putida) 		no annotation 5 ALA B   9
PHE B  97
ILE B  67
GLY B  46
THR B  17
 None
 1.22A 5jlcA-1jmzB:
undetectable		 5jlcA-1jmzB:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lln ANTIVIRAL PROTEIN 3

(Phytolacca
americana) 		PF00161
(RIP) 		5 ALA A  62
GLY A 192
PHE A 162
THR A 171
MET A 169
 None
None
None
None
MLY  A 134 ( 4.8A)
 1.26A 5jlcA-1llnA:
undetectable		 5jlcA-1llnA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mqq ALPHA-D-GLUCURONIDAS
E

(Geobacillus
stearothermophilus) 		PF03648
(Glyco_hydro_67N)
PF07477
(Glyco_hydro_67C)
PF07488
(Glyco_hydro_67M) 		5 ALA A 338
PHE A 663
ILE A 608
GLY A 550
PHE A 588
 None
 1.09A 5jlcA-1mqqA:
undetectable		 5jlcA-1mqqA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pe9 PECTATE LYASE A

(Dickeya
chrysanthemi) 		PF00544
(Pec_lyase_C) 		5 ILE A 338
PHE A 253
GLY A  16
THR A 197
HIS A 159
 None
 1.12A 5jlcA-1pe9A:
undetectable		 5jlcA-1pe9A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli) 		PF00724
(Oxidored_FMN)
PF07992
(Pyr_redox_2) 		5 ALA A 415
PHE A 268
ILE A 249
PHE A 527
HIS A 579
 FAD  A 701 (-3.6A)
None
None
None
None
 1.16A 5jlcA-1ps9A:
undetectable		 5jlcA-1ps9A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1puj CONSERVED
HYPOTHETICAL PROTEIN
YLQF

(Bacillus
subtilis) 		PF01926
(MMR_HSR1) 		5 ALA A 240
ILE A  35
GLY A 193
PHE A 272
THR A 259
 None
 1.01A 5jlcA-1pujA:
undetectable		 5jlcA-1pujA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u8v GAMMA-AMINOBUTYRATE
METABOLISM
DEHYDRATASE/ISOMERAS
E

(Clostridium
aminobutyricum) 		PF03241
(HpaB)
PF11794
(HpaB_N) 		5 ILE A 443
TYR A 452
GLY A 309
HIS A 335
PHE A 376
 None
 1.30A 5jlcA-1u8vA:
undetectable		 5jlcA-1u8vA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ve1 O-ACETYLSERINE
SULFHYDRYLASE

(Thermus
thermophilus) 		PF00291
(PALP) 		5 ALA A  78
PHE A 246
TYR A 301
GLY A 265
THR A  73
 None
 1.33A 5jlcA-1ve1A:
undetectable		 5jlcA-1ve1A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zef ALKALINE PHOSPHATASE

(Homo sapiens) 		PF00245
(Alk_phosphatase) 		5 ALA A 157
PHE A  74
GLY A 342
PHE A 307
THR A 147
 None
 1.27A 5jlcA-1zefA:
undetectable		 5jlcA-1zefA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zh8 OXIDOREDUCTASE

(Thermotoga
maritima) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		5 ALA A 147
PHE A 310
PHE A 226
THR A 251
MET A 154
 None
 1.33A 5jlcA-1zh8A:
undetectable		 5jlcA-1zh8A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zsw GLYOXALASE FAMILY
PROTEIN

(Bacillus cereus) 		PF00903
(Glyoxalase) 		5 ALA A 234
TYR A 180
GLY A 158
PHE A 178
THR A 273
 None
 1.19A 5jlcA-1zswA:
undetectable		 5jlcA-1zswA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1

(Homo sapiens) 		PF00330
(Aconitase)
PF00694
(Aconitase_C) 		5 ALA A 794
ILE A 686
GLY A 710
HIS A 804
PHE A 724
 None
 1.01A 5jlcA-2b3xA:
undetectable		 5jlcA-2b3xA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bfr HYPOTHETICAL PROTEIN
AF1521

(Archaeoglobus
fulgidus) 		PF01661
(Macro) 		5 ALA A 127
ILE A 144
TYR A 145
GLY A  40
THR A  59
 None
ADP  A1193 (-3.7A)
ADP  A1193 (-3.4A)
None
None
 0.98A 5jlcA-2bfrA:
undetectable		 5jlcA-2bfrA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bwg GMP REDUCTASE I

(Homo sapiens) 		PF00478
(IMPDH) 		5 ALA A 206
TYR A 285
GLY A  59
THR A  74
MET A 240
 None
None
None
None
5GP  A1340 (-3.5A)
 1.32A 5jlcA-2bwgA:
undetectable		 5jlcA-2bwgA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bwg GMP REDUCTASE I

(Homo sapiens) 		PF00478
(IMPDH) 		5 ALA A 209
TYR A 285
GLY A  59
THR A  74
MET A 240
 None
None
None
None
5GP  A1340 (-3.5A)
 1.34A 5jlcA-2bwgA:
undetectable		 5jlcA-2bwgA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cwq HYPOTHETICAL PROTEIN
TTHA0727

(Thermus
thermophilus) 		PF02627
(CMD) 		5 ALA A  90
ILE A  24
GLY A  39
THR A  43
THR A  56
 None
 1.35A 5jlcA-2cwqA:
undetectable		 5jlcA-2cwqA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dd7 GREEN FLUORESCENT
PROTEIN

(Chiridius
poppei) 		PF01353
(GFP) 		5 ALA A 155
TYR A  59
PHE A 182
ILE A  71
TYR A  72
 None
CR2  A  56 ( 4.4A)
None
None
None
 1.16A 5jlcA-2dd7A:
undetectable		 5jlcA-2dd7A:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f4o PEPTIDE N-GLYCANASE

(Mus musculus) 		PF01841
(Transglut_core) 		5 ALA A 319
PHE A 289
ILE A 245
PHE A 238
THR A 314
 None
 1.34A 5jlcA-2f4oA:
undetectable		 5jlcA-2f4oA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hf0 BILE SALT HYDROLASE

(Bifidobacterium
longum) 		PF02275
(CBAH) 		5 ALA A 230
ILE A  29
PHE A 275
GLY A  57
THR A 171
 None
 1.32A 5jlcA-2hf0A:
undetectable		 5jlcA-2hf0A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2inc TOLUENE, O-XYLENE
MONOOXYGENASE
OXYGENASE SUBUNIT

(Pseudomonas
stutzeri) 		PF02332
(Phenol_Hydrox)
PF04945
(YHS) 		5 ILE A 244
GLY A 238
THR A 193
PHE A 117
THR A 182
 None
 1.32A 5jlcA-2incA:
undetectable		 5jlcA-2incA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jtc STREPTOPAIN

(Streptococcus
pyogenes) 		PF01640
(Peptidase_C10) 		5 PHE A 151
ILE A  90
GLY A 124
THR A  45
THR A 103
 None
 1.21A 5jlcA-2jtcA:
undetectable		 5jlcA-2jtcA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o3b NUCLEASE

(Nostoc sp. PCC
7120) 		PF01223
(Endonuclease_NS) 		5 ALA A 140
TYR A 254
GLY A 184
THR A 195
MET A 148
 None
 1.03A 5jlcA-2o3bA:
undetectable		 5jlcA-2o3bA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o6x SECRETED CATHEPSIN L
1

(Fasciola
hepatica) 		PF00112
(Peptidase_C1)
PF08246
(Inhibitor_I29) 		5 ALA A 231
TYR A 248
TYR A  56
GLY A  59
HIS A 260
 None
 1.18A 5jlcA-2o6xA:
undetectable		 5jlcA-2o6xA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qm0 BES

(Bacillus cereus) 		PF00756
(Esterase) 		5 ALA A 249
PHE A 128
ILE A 132
GLY A  85
PHE A 178
 None
 1.16A 5jlcA-2qm0A:
undetectable		 5jlcA-2qm0A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qm0 BES

(Bacillus cereus) 		PF00756
(Esterase) 		5 PHE A 128
ILE A 132
PHE A 101
GLY A  85
PHE A 178
 None
 1.24A 5jlcA-2qm0A:
undetectable		 5jlcA-2qm0A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qqp LARGE CAPSID PROTEIN
SMALL CAPSID PROTEIN

(Providence
virus) 		PF03566
(Peptidase_A21) 		5 ALA A 491
ILE B 582
PHE A  85
GLY B 568
MET A  89
 None
 1.28A 5jlcA-2qqpA:
undetectable		 5jlcA-2qqpA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r6f EXCINUCLEASE ABC
SUBUNIT A

(Geobacillus
stearothermophilus) 		PF00005
(ABC_tran) 		5 ALA A 482
ILE A 115
PHE A 441
GLY A 422
THR A 477
 None
 1.19A 5jlcA-2r6fA:
undetectable		 5jlcA-2r6fA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vca ALPHA-N-ACETYLGLUCOS
AMINIDASE

(Clostridium
perfringens) 		PF00754
(F5_F8_type_C)
PF05089
(NAGLU)
PF12971
(NAGLU_N)
PF12972
(NAGLU_C) 		5 ALA A 602
PHE A 704
ILE A 644
THR A 654
MET A 572
 None
 1.21A 5jlcA-2vcaA:
undetectable		 5jlcA-2vcaA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vca ALPHA-N-ACETYLGLUCOS
AMINIDASE

(Clostridium
perfringens) 		PF00754
(F5_F8_type_C)
PF05089
(NAGLU)
PF12971
(NAGLU_N)
PF12972
(NAGLU_C) 		5 PHE A 300
ILE A 333
TYR A 368
GLY A 477
THR A 487
 None
None
None
None
GOL  A1913 ( 4.4A)
 1.25A 5jlcA-2vcaA:
undetectable		 5jlcA-2vcaA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vr2 DIHYDROPYRIMIDINASE

(Homo sapiens) 		PF01979
(Amidohydro_1) 		5 ALA A 113
ILE A 234
GLY A 270
HIS A  69
PHE A 161
 None
None
None
ZN  A1494 (-3.3A)
None
 1.16A 5jlcA-2vr2A:
undetectable		 5jlcA-2vr2A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xrm INTRACELLULAR
SUBTILISIN PROTEASE

(Bacillus
clausii) 		PF00082
(Peptidase_S8) 		5 ALA A  60
PHE A 211
ILE A  27
GLY A 231
THR A  88
 None
 1.22A 5jlcA-2xrmA:
undetectable		 5jlcA-2xrmA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y8n 4-HYDROXYPHENYLACETA
TE DECARBOXYLASE
LARGE SUBUNIT

(Clostridium
scatologenes) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		5 ALA A  51
PHE A 537
ILE A 750
PHE A 214
GLY A 532
 None
 1.14A 5jlcA-2y8nA:
undetectable		 5jlcA-2y8nA:
20.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yoc PULLULANASE

(Klebsiella
oxytoca) 		PF02922
(CBM_48)
PF03714
(PUD)
PF11852
(DUF3372) 		5 ALA A 471
PHE A 691
ILE A 689
PHE A 664
THR A 596
 None
 1.33A 5jlcA-2yocA:
undetectable		 5jlcA-2yocA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zsk 226AA LONG
HYPOTHETICAL
ASPARTATE RACEMASE

(Pyrococcus
horikoshii) 		PF01177
(Asp_Glu_race) 		5 ALA A 107
PHE A  48
ILE A  61
GLY A   9
THR A  15
 None
 1.13A 5jlcA-2zskA:
undetectable		 5jlcA-2zskA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cgh SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF12741
(SusD-like) 		5 ALA A 149
PHE A 317
ILE A 302
GLY A 348
THR A  66
 None
 1.31A 5jlcA-3cghA:
undetectable		 5jlcA-3cghA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hj4 MINOR
EDITOSOME-ASSOCIATED
TUTASE

(Trypanosoma
brucei) 		no annotation 5 ALA A  18
PHE A 358
ILE A 354
PHE A 251
THR A 187
 None
 1.12A 5jlcA-3hj4A:
undetectable		 5jlcA-3hj4A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hp0 PUTATIVE POLYKETIDE
BIOSYNTHESIS
ENOYL-COA HYDRATASE
HOMOLOG PKSH

(Bacillus
subtilis) 		PF00378
(ECH_1) 		5 ALA A 226
PHE A  22
ILE A   9
PHE A 118
THR A 103
 None
 1.33A 5jlcA-3hp0A:
undetectable		 5jlcA-3hp0A:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i45 TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN

(Rhodospirillum
rubrum) 		PF13458
(Peripla_BP_6) 		5 ALA A 248
PHE A 270
TYR A 274
GLY A 289
THR A 235
 None
 1.17A 5jlcA-3i45A:
undetectable		 5jlcA-3i45A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ig4 XAA-PRO
AMINOPEPTIDASE

(Bacillus
anthracis) 		PF00557
(Peptidase_M24)
PF05195
(AMP_N) 		5 ALA A 209
ILE A 285
GLY A 371
PHE A 272
THR A 227
 None
 1.35A 5jlcA-3ig4A:
1.8		 5jlcA-3ig4A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jq3 LOMBRICINE KINASE

(Urechis caupo) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		5 ALA A 201
ILE A 118
PHE A 212
GLY A 241
THR A 146
 None
 1.23A 5jlcA-3jq3A:
undetectable		 5jlcA-3jq3A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3led 3-OXOACYL-ACYL
CARRIER PROTEIN
SYNTHASE III

(Rhodopseudomonas
palustris) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 ALA A 338
PHE A  57
PHE A 199
HIS A 296
THR A 330
 None
 1.33A 5jlcA-3ledA:
undetectable		 5jlcA-3ledA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvu TENA FAMILY
TRANSCRIPTIONAL
REGULATOR

(Ruegeria sp.
TM1040) 		PF03070
(TENA_THI-4) 		5 ALA A 112
ILE A 164
GLY A  35
HIS A  44
THR A 224
 EDO  A 236 (-3.2A)
None
None
CL  A 239 (-4.0A)
None
 1.35A 5jlcA-3mvuA:
undetectable		 5jlcA-3mvuA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1
SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT BETA-1

(Sus scrofa) 		PF00122
(E1-E2_ATPase)
PF00287
(Na_K-ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF13246
(Cation_ATPase) 		6 PHE B  50
ILE B  54
GLY A 857
THR A 918
HIS A 912
THR A 797
 None
None
None
None
None
OBN  A   1 (-2.8A)
 1.43A 5jlcA-3n23B:
undetectable		 5jlcA-3n23B:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nlc UNCHARACTERIZED
PROTEIN VP0956

(Vibrio
parahaemolyticus) 		no annotation 5 ALA A 511
ILE A 299
TYR A 318
GLY A 338
PHE A 333
 None
 0.96A 5jlcA-3nlcA:
undetectable		 5jlcA-3nlcA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nmb PUTATIVE SUGAR
HYDROLASE

(Bacteroides
ovatus) 		PF06439
(DUF1080) 		5 ALA A 241
PHE A 119
ILE A 268
GLY A 266
THR A 236
 None
 1.33A 5jlcA-3nmbA:
undetectable		 5jlcA-3nmbA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nra ASPARTATE
AMINOTRANSFERASE

(Rhodobacter
sphaeroides) 		PF00155
(Aminotran_1_2) 		5 ALA A 179
PHE A   7
ILE A   3
PHE A 144
THR A 121
 None
 1.27A 5jlcA-3nraA:
undetectable		 5jlcA-3nraA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oqq PUTATIVE LIPOPROTEIN

(Bacteroides
ovatus) 		PF16129
(DUF4841)
PF16130
(DUF4842) 		5 ALA A 231
ILE A 453
TYR A 455
GLY A 207
THR A 291
 None
None
None
CA  A 457 (-3.7A)
PGE  A 462 (-3.4A)
 1.36A 5jlcA-3oqqA:
undetectable		 5jlcA-3oqqA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqo CYSTEINYL-TRNA
SYNTHETASE

(Coxiella
burnetii) 		PF01406
(tRNA-synt_1e)
PF09190
(DALR_2) 		5 PHE A  48
ILE A  47
TYR A 299
GLY A 228
HIS A 158
 None
 1.15A 5jlcA-3tqoA:
undetectable		 5jlcA-3tqoA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w9h ACRIFLAVINE
RESISTANCE PROTEIN B

(Escherichia
coli) 		PF00873
(ACR_tran) 		5 ALA A 654
PHE A 178
ILE A 277
PHE A 628
THR A 648
 None
 1.25A 5jlcA-3w9hA:
undetectable		 5jlcA-3w9hA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wrf NON-REDUCING END
BETA-L-ARABINOFURANO
SIDASE

(Bifidobacterium
longum) 		PF07944
(Glyco_hydro_127) 		5 TYR A 385
ILE A 377
GLY A 372
THR A 312
THR A 318
 None
 1.26A 5jlcA-3wrfA:
undetectable		 5jlcA-3wrfA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wvj BETA-GLUCANASE

(Ruminiclostridium
thermocellum) 		PF00722
(Glyco_hydro_16) 		5 TYR A 103
PHE A 180
ILE A 187
THR A 126
THR A  31
 None
 1.35A 5jlcA-3wvjA:
undetectable		 5jlcA-3wvjA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ain GLYCINE BETAINE
TRANSPORTER BETP

(Corynebacterium
glutamicum) 		PF02028
(BCCT) 		5 PHE A 380
TYR A 197
GLY A 249
THR A 522
PHE A 110
 None
 1.26A 5jlcA-4ainA:
2.0		 5jlcA-4ainA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c2t DNA HELICASE II

(Deinococcus
radiodurans) 		PF00580
(UvrD-helicase)
PF13361
(UvrD_C) 		5 ALA A 244
ILE A 260
TYR A 261
GLY A 575
PHE A  92
 None
None
None
ANP  A1664 (-3.4A)
None
 1.17A 5jlcA-4c2tA:
undetectable		 5jlcA-4c2tA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c30 DNA HELICASE II

(Deinococcus
radiodurans) 		PF00580
(UvrD-helicase)
PF13361
(UvrD_C) 		5 ALA A 244
ILE A 260
TYR A 261
GLY A 575
PHE A  92
 None
None
None
ANP  A1662 ( 3.7A)
None
 1.29A 5jlcA-4c30A:
undetectable		 5jlcA-4c30A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d72 GLYCOSIDE HYDROLASE

(Streptococcus
pneumoniae) 		PF08306
(Glyco_hydro_98M)
PF08307
(Glyco_hydro_98C) 		5 TYR A 494
ILE A 541
GLY A 553
PHE A 493
THR A 460
 None
 1.03A 5jlcA-4d72A:
undetectable		 5jlcA-4d72A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g9i HYDROGENASE
MATURATION PROTEIN
HYPF

(Thermococcus
kodakarensis) 		PF00708
(Acylphosphatase)
PF00814
(Peptidase_M22)
PF01300
(Sua5_yciO_yrdC)
PF07503
(zf-HYPF) 		5 ALA A 710
PHE A 666
ILE A 560
TYR A 541
THR A 722
 None
 1.23A 5jlcA-4g9iA:
undetectable		 5jlcA-4g9iA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hxc PUTATIVE GLYCOSYL
HYDROLASE

(Bacteroides
uniformis) 		PF06439
(DUF1080) 		5 ALA A 244
PHE A 122
ILE A 271
GLY A 269
THR A 239
 None
 1.35A 5jlcA-4hxcA:
undetectable		 5jlcA-4hxcA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l35 CRUXRHODOPSIN-3

(Haloarcula
vallismortis) 		PF01036
(Bac_rhodopsin) 		5 ALA A 101
TYR A  41
ILE A  26
GLY A  21
PHE A  40
 None
 1.36A 5jlcA-4l35A:
1.0		 5jlcA-4l35A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lmb CYSTEINE SYNTHASE

(Microcystis
aeruginosa) 		PF00291
(PALP) 		5 ALA A 132
ILE A 240
GLY A 178
PHE A 230
THR A  74
 None
None
None
None
CYS  A 401 (-3.6A)
 1.13A 5jlcA-4lmbA:
undetectable		 5jlcA-4lmbA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mni TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT

(Polaromonas sp.
JS666) 		PF03480
(DctP) 		5 ALA A 182
GLY A 271
THR A 275
PHE A 228
THR A 153
 None
 1.35A 5jlcA-4mniA:
undetectable		 5jlcA-4mniA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n7t PHOSPHOPENTOMUTASE

(Streptococcus
mutans) 		PF01676
(Metalloenzyme) 		5 ALA A 299
ILE A 383
PHE A 254
GLY A 101
HIS A 340
 None
None
None
None
MN  A 501 (-3.2A)
 1.03A 5jlcA-4n7tA:
1.0		 5jlcA-4n7tA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4phs PUTATIVE
GLYCOSYLTRANSFERASE
(GALT1)

(Streptococcus
parasanguinis) 		PF08759
(GT-D) 		5 ALA A 191
ILE A  42
TYR A  44
GLY A  30
THR A 112
 None
None
UDP  A 301 (-3.5A)
None
None
 1.01A 5jlcA-4phsA:
undetectable		 5jlcA-4phsA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pju COHESIN SUBUNIT SA-2

(Homo sapiens) 		PF08514
(STAG) 		5 ALA A 857
PHE A 768
ILE A 771
TYR A 775
THR A 695
 None
 1.27A 5jlcA-4pjuA:
undetectable		 5jlcA-4pjuA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r3u 2-HYDROXYISOBUTYRYL-
COA MUTASE LARGE
SUBUNIT

(Aquincola
tertiaricarbonis) 		PF01642
(MM_CoA_mutase) 		5 ALA A 152
ILE A 201
PHE A 166
THR A 146
MET A 542
 None
 1.23A 5jlcA-4r3uA:
undetectable		 5jlcA-4r3uA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rv2 MAOC FAMILY PROTEIN
UPF0336 PROTEIN
MSMEG_1340/MSMEI_130
2

(Mycolicibacterium
smegmatis) 		PF01575
(MaoC_dehydratas)
PF13452
(MaoC_dehydrat_N) 		6 PHE B 104
ILE B  20
PHE B 132
GLY B  67
THR A  58
THR A 141
 None
 1.23A 5jlcA-4rv2B:
undetectable		 5jlcA-4rv2B:
13.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4uhi STEROL 14-ALPHA
DEMETHYLASE

(Homo sapiens) 		PF00067
(p450) 		5 ALA A  74
TYR A 131
PHE A 139
TYR A 145
PHE A 234
 VFV  A 600 ( 4.9A)
VFV  A 580 (-4.1A)
VFV  A 580 (-4.2A)
HEM  A 540 (-4.5A)
VFV  A 580 (-3.5A)
 1.00A 5jlcA-4uhiA:
44.2		 5jlcA-4uhiA:
38.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4uhi STEROL 14-ALPHA
DEMETHYLASE

(Homo sapiens) 		PF00067
(p450) 		5 ALA A  74
TYR A 131
PHE A 139
TYR A 145
THR A 315
 VFV  A 600 ( 4.9A)
VFV  A 580 (-4.1A)
VFV  A 580 (-4.2A)
HEM  A 540 (-4.5A)
HEM  A 540 (-3.6A)
 0.74A 5jlcA-4uhiA:
44.2		 5jlcA-4uhiA:
38.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y5r METHYLAMINE
UTILIZATION PROTEIN
MAUG

(Paracoccus
denitrificans) 		PF03150
(CCP_MauG) 		5 ALA A  73
PHE A 185
PHE A 345
PHE A 171
THR A 219
 HEC  A 402 ( 4.6A)
None
None
None
None
 1.30A 5jlcA-4y5rA:
undetectable		 5jlcA-4y5rA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y9s EPOXIDE HYDROLASE

(Solanum
tuberosum) 		PF00561
(Abhydrolase_1) 		5 ALA A 298
TYR A 154
PHE A 168
ILE A 164
HIS A 104
 None
 1.30A 5jlcA-4y9sA:
undetectable		 5jlcA-4y9sA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yw5 NEURAMINIDASE C

(Streptococcus
pneumoniae) 		PF02012
(BNR)
PF02973
(Sialidase)
PF13088
(BNR_2) 		5 TYR A 608
ILE A 638
TYR A 598
PHE A 626
GLY A 670
 None
 1.03A 5jlcA-4yw5A:
undetectable		 5jlcA-4yw5A:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z4l CELLOBIOSE
2-EPIMERASE

(Caldicellulosiruptor
saccharolyticus) 		PF07221
(GlcNAc_2-epim) 		5 ALA A 258
ILE A 293
TYR A 245
PHE A 317
PHE A 228
 None
 1.35A 5jlcA-4z4lA:
undetectable		 5jlcA-4z4lA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zmh UNCHARACTERIZED
PROTEIN

(Saccharophagus
degradans) 		PF15979
(Glyco_hydro_115) 		5 ALA A 925
GLY A 934
THR A 932
HIS A 929
THR A 872
 None
 1.24A 5jlcA-4zmhA:
1.0		 5jlcA-4zmhA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ahk ACETOLACTATE
SYNTHASE II, LARGE
SUBUNIT

(Pseudomonas
protegens) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 TYR A 257
PHE A 227
GLY A 218
HIS A 414
THR A  62
 None
None
FAD  A 701 (-3.1A)
None
None
 1.07A 5jlcA-5ahkA:
undetectable		 5jlcA-5ahkA:
23.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fsa CYP51 VARIANT1

(Candida
albicans) 		PF00067
(p450) 		6 ALA A  61
PHE A 228
GLY A 308
THR A 311
HIS A 377
MET A 508
 X2N  A 590 (-3.5A)
X2N  A 590 (-4.9A)
HEM  A 580 (-3.6A)
HEM  A 580 (-3.6A)
X2N  A 590 (-4.3A)
X2N  A 590 (-4.8A)
 1.00A 5jlcA-5fsaA:
54.7		 5jlcA-5fsaA:
62.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fsa CYP51 VARIANT1

(Candida
albicans) 		PF00067
(p450) 		11 ALA A  61
TYR A 118
PHE A 126
ILE A 131
TYR A 132
PHE A 228
GLY A 307
THR A 311
HIS A 377
PHE A 380
MET A 508
 X2N  A 590 (-3.5A)
X2N  A 590 ( 4.0A)
X2N  A 590 (-4.8A)
X2N  A 590 (-4.2A)
HEM  A 580 (-4.1A)
X2N  A 590 (-4.9A)
X2N  A 590 (-3.5A)
HEM  A 580 (-3.6A)
X2N  A 590 (-4.3A)
X2N  A 590 ( 4.8A)
X2N  A 590 (-4.8A)
 0.53A 5jlcA-5fsaA:
54.7		 5jlcA-5fsaA:
62.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fsa CYP51 VARIANT1

(Candida
albicans) 		PF00067
(p450) 		5 TYR A 132
PHE A 126
PHE A 228
GLY A 307
THR A 311
 HEM  A 580 (-4.1A)
X2N  A 590 (-4.8A)
X2N  A 590 (-4.9A)
X2N  A 590 (-3.5A)
HEM  A 580 (-3.6A)
 1.18A 5jlcA-5fsaA:
54.7		 5jlcA-5fsaA:
62.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5z ABC TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN

(Streptococcus
pneumoniae) 		PF01547
(SBP_bac_1) 		5 ALA A  90
ILE A 142
TYR A 374
PHE A 349
THR A 154
 None
 1.30A 5jlcA-5g5zA:
undetectable		 5jlcA-5g5zA:
23.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE

(Saccharomyces
cerevisiae) 		PF00067
(p450) 		5 ALA A  69
GLY A 315
THR A 318
HIS A 381
THR A 507
 None
HEM  A 601 (-3.5A)
HEM  A 601 (-3.4A)
None
None
 0.93A 5jlcA-5hs1A:
57.8		 5jlcA-5hs1A:
84.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE

(Saccharomyces
cerevisiae) 		PF00067
(p450) 		11 ALA A  69
TYR A 126
PHE A 134
ILE A 139
TYR A 140
PHE A 236
GLY A 314
THR A 318
HIS A 381
PHE A 384
THR A 507
 None
VOR  A 602 ( 3.8A)
VOR  A 602 (-4.7A)
VOR  A 602 (-4.3A)
HEM  A 601 (-4.3A)
VOR  A 602 (-4.4A)
VOR  A 602 (-3.0A)
HEM  A 601 (-3.4A)
None
None
None
 0.66A 5jlcA-5hs1A:
57.8		 5jlcA-5hs1A:
84.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqm GLYCOSYL HYDROLASES
FAMILY 2, SUGAR
BINDING DOMAIN

(Bacteroides
thetaiotaomicron) 		PF17132
(Glyco_hydro_106) 		5 ALA A1017
PHE A 562
ILE A 621
TYR A 617
PHE A 595
 None
 1.11A 5jlcA-5mqmA:
undetectable		 5jlcA-5mqmA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uao TRYPTOPHANE-5-HALOGE
NASE

(Microbispora
sp. ATCC
PTA-5024) 		PF04820
(Trp_halogenase) 		5 ALA A 456
PHE A 234
ILE A  68
THR A 256
HIS A 404
 None
None
FAD  A 601 (-3.8A)
None
None
 1.34A 5jlcA-5uaoA:
undetectable		 5jlcA-5uaoA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v4a GLYCOSYLTRANSFERASE
(DUF1792)

(Streptococcus
sanguinis) 		PF08759
(GT-D) 		5 ALA A 191
ILE A  41
TYR A  43
GLY A  29
THR A 112
 None
None
UDP  A 301 (-3.4A)
None
None
 1.01A 5jlcA-5v4aA:
undetectable		 5jlcA-5v4aA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vkv CYTOCHROME C-TYPE
BIOGENESIS PROTEIN
CCDA

(Thermus
thermophilus) 		no annotation 5 ALA A 166
PHE A  54
TYR A 151
PHE A  50
PHE A  16
 None
 1.23A 5jlcA-5vkvA:
undetectable		 5jlcA-5vkvA:
9.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vkv CYTOCHROME C-TYPE
BIOGENESIS PROTEIN
CCDA

(Thermus
thermophilus) 		no annotation 5 PHE A  54
TYR A 151
PHE A  50
THR A 125
PHE A  16
 None
 1.30A 5jlcA-5vkvA:
undetectable		 5jlcA-5vkvA:
9.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w4b ADENOSYLHOMOCYSTEINA
SE

(Homo sapiens) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		5 ALA A 350
ILE A 114
TYR A 110
GLY A 133
THR A 159
 None
 1.21A 5jlcA-5w4bA:
undetectable		 5jlcA-5w4bA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wl7 ENGINEERED CHALCONE
ISOMERASE ANCCHI*

(unidentified) 		no annotation 5 ALA A 129
PHE A  13
ILE A  11
GLY A  32
MET A 189
 None
None
None
None
CL  A 302 ( 4.1A)
 1.34A 5jlcA-5wl7A:
undetectable		 5jlcA-5wl7A:
9.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x6x MRNA CAPPING ENZYME
P5

(Rice dwarf
virus) 		no annotation 5 ALA C 109
ILE C 208
TYR C 215
PHE C 181
MET C 577
 None
None
EDO  C 902 (-4.3A)
None
None
 1.32A 5jlcA-5x6xC:
undetectable		 5jlcA-5x6xC:
10.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6ay4 CYP51, STEROL
14ALPHA-DEMETHYLASE

(Naegleria
fowleri) 		no annotation 5 ALA A  54
TYR A 107
PHE A 114
TYR A 120
THR A 465
 None
TPF  A 506 (-4.2A)
TPF  A 506 (-4.4A)
None
None
 0.98A 5jlcA-6ay4A:
42.3		 5jlcA-6ay4A:
32.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6ay4 CYP51, STEROL
14ALPHA-DEMETHYLASE

(Naegleria
fowleri) 		no annotation 5 TYR A 107
PHE A 114
TYR A 120
THR A 297
THR A 465
 TPF  A 506 (-4.2A)
TPF  A 506 (-4.4A)
None
HEM  A 501 (-3.4A)
None
 0.65A 5jlcA-6ay4A:
42.3		 5jlcA-6ay4A:
32.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b4h NUCLEOPORIN GLE1

(Chaetomium
thermophilum) 		no annotation 5 ALA A 266
PHE A 375
PHE A 333
GLY A 421
THR A 261
 None
 1.27A 5jlcA-6b4hA:
undetectable		 5jlcA-6b4hA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bnp UNCONVENTIONAL
MYOSIN-VI

(Sus scrofa) 		no annotation 5 ALA I 422
PHE I 577
ILE I 579
PHE I 543
PHE I 647
 None
 1.17A 5jlcA-6bnpI:
undetectable		 5jlcA-6bnpI:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c49 ALCOHOL
DEHYDROGENASE

(Acinetobacter
baumannii) 		no annotation 5 ALA A 136
ILE A 322
THR A  57
HIS A 121
THR A  92
 None
 1.18A 5jlcA-6c49A:
undetectable		 5jlcA-6c49A:
8.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f0k ACTF
POLYSULPHIDE
REDUCTASE NRFD

(Rhodothermus
marinus) 		no annotation 5 ALA C 330
PHE F 281
TYR F 284
THR C 315
PHE C 267
 None
 1.13A 5jlcA-6f0kC:
1.1		 5jlcA-6f0kC:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f74 ALCOHOL OXIDASE

(Thermothelomyces
thermophila) 		no annotation 5 ALA A 129
ILE A 434
GLY A 546
THR A 580
THR A 154
 None
None
None
None
FAD  A 601 (-4.2A)
 1.13A 5jlcA-6f74A:
undetectable		 5jlcA-6f74A:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a0e XYLOSE ISOMERASE

(Thermotoga
neapolitana) 		PF01261
(AP_endonuc_2) 		4 GLY A 226
THR A 225
GLY A 152
LEU A 212
 None
 0.71A 5jlcA-1a0eA:
0.0		 5jlcA-1a0eA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bxn PROTEIN (RIBULOSE
BISPHOSPHATE
CARBOXYLASE LARGE
CHAIN)

(Cupriavidus
necator) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 GLY A 248
THR A 249
GLY A 310
LEU A 272
 None
 0.56A 5jlcA-1bxnA:
0.0		 5jlcA-1bxnA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e5d RUBREDOXIN:OXYGEN
OXIDOREDUCTASE

(Desulfovibrio
gigas) 		PF00258
(Flavodoxin_1)
PF00753
(Lactamase_B) 		4 GLY A 361
THR A 360
GLY A  25
LEU A 332
 None
 0.67A 5jlcA-1e5dA:
0.4		 5jlcA-1e5dA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6v METHYL-COENZYME M
REDUCTASE I ALPHA
SUBUNIT
METHYL-COENZYME M
REDUCTASE I BETA
SUBUNIT
METHYL-COENZYME M
REDUCTASE I GAMMA
SUBUNIT

(Methanopyrus
kandleri) 		PF02240
(MCR_gamma)
PF02241
(MCR_beta)
PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N)
PF02783
(MCR_beta_N) 		4 GLY B 344
THR B 343
GLY A 384
LEU C 235
 None
 0.81A 5jlcA-1e6vB:
0.8		 5jlcA-1e6vB:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6z CHITINASE B

(Serratia
marcescens) 		PF00704
(Glyco_hydro_18) 		4 TYR A  10
GLY A   9
GLY A 279
LEU A 211
 NGO  A 502 (-3.2A)
None
None
None
 0.71A 5jlcA-1e6zA:
0.0		 5jlcA-1e6zA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g8k ARSENITE OXIDASE

(Alcaligenes
faecalis) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		4 GLY A 114
THR A 113
GLY A 172
LEU A 515
 None
None
None
MGD  A5001 (-4.0A)
 0.87A 5jlcA-1g8kA:
0.0		 5jlcA-1g8kA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l2q MONOMETHYLAMINE
METHYLTRANSFERASE

(Methanosarcina
barkeri) 		PF05369
(MtmB) 		4 GLY A 380
THR A 379
GLY A 395
LEU A 364
 None
 0.69A 5jlcA-1l2qA:
0.0		 5jlcA-1l2qA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
METHANOL
DEHYDROGENASE
SUBUNIT 2

(Paracoccus
denitrificans) 		PF01011
(PQQ)
PF02315
(MDH)
PF13360
(PQQ_2) 		4 TYR B   1
GLY B   3
THR B   4
GLY A 182
 None
 0.73A 5jlcA-1lrwB:
undetectable		 5jlcA-1lrwB:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n7d LOW-DENSITY
LIPOPROTEIN RECEPTOR

(Homo sapiens) 		PF00057
(Ldl_recept_a)
PF00058
(Ldl_recept_b)
PF07645
(EGF_CA)
PF14670
(FXa_inhibition) 		4 GLY A 516
THR A 517
GLY A 552
LEU A 534
 None
 0.87A 5jlcA-1n7dA:
undetectable		 5jlcA-1n7dA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1odf HYPOTHETICAL 33.3
KDA PROTEIN IN
ADE3-SER2 INTERGENIC
REGION

(Saccharomyces
cerevisiae) 		no annotation 4 GLY A 146
THR A 145
GLY A 164
LEU A 107
 None
 0.81A 5jlcA-1odfA:
undetectable		 5jlcA-1odfA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pbk FKBP25

(Homo sapiens) 		PF00254
(FKBP_C) 		4 GLY A 142
THR A 143
GLY A 119
LEU A 190
 None
 0.91A 5jlcA-1pbkA:
undetectable		 5jlcA-1pbkA:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r82 GLYCOPROTEIN-FUCOSYL
GALACTOSIDE
ALPHA-GALACTOSYLTRAN
SFERASE

(Homo sapiens) 		PF03414
(Glyco_transf_6) 		4 GLY A 167
THR A 166
GLY A 230
LEU A 118
 None
 0.93A 5jlcA-1r82A:
undetectable		 5jlcA-1r82A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w6s METHANOL
DEHYDROGENASE
SUBUNIT 1
METHANOL
DEHYDROGENASE
SUBUNIT 2

(Methylobacterium
extorquens) 		PF01011
(PQQ)
PF02315
(MDH)
PF13360
(PQQ_2) 		4 TYR B1001
GLY B1003
THR B1004
GLY A 182
 None
 0.65A 5jlcA-1w6sB:
undetectable		 5jlcA-1w6sB:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xc3 PUTATIVE
FRUCTOKINASE

(Bacillus
subtilis) 		PF00480
(ROK) 		4 TYR A  70
GLY A  71
THR A  72
LEU A 142
 None
 0.78A 5jlcA-1xc3A:
undetectable		 5jlcA-1xc3A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xez HEMOLYSIN

(Vibrio cholerae) 		PF07968
(Leukocidin)
PF12563
(Hemolysin_N)
PF16458
(Beta-prism_lec) 		4 TYR A 666
GLY A 641
GLY A 628
LEU A 662
 None
 0.91A 5jlcA-1xezA:
undetectable		 5jlcA-1xezA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xfg GLUCOSAMINE--FRUCTOS
E-6-PHOSPHATE
AMINOTRANSFERASE
[ISOMERIZING]

(Escherichia
coli) 		PF13522
(GATase_6) 		4 GLY A 226
THR A 225
GLY A  68
LEU A 141
 None
 0.83A 5jlcA-1xfgA:
undetectable		 5jlcA-1xfgA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yzy HYPOTHETICAL PROTEIN
HI1011

(Haemophilus
influenzae) 		PF07005
(DUF1537)
PF17042
(DUF1357_C) 		4 GLY A 236
THR A 237
GLY A 354
LEU A 382
 None
 0.66A 5jlcA-1yzyA:
undetectable		 5jlcA-1yzyA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c1w ENDOU PROTEIN

(Xenopus laevis) 		PF09412
(XendoU) 		4 TYR A  43
GLY A  42
GLY A 232
LEU A  37
 None
 0.80A 5jlcA-2c1wA:
undetectable		 5jlcA-2c1wA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cwl MANGANESE-FREE
PSEUDOCATALASE

(Thermus
thermophilus) 		PF05067
(Mn_catalase) 		4 TYR A 224
GLY A 179
GLY A 275
LEU A   8
 None
 0.86A 5jlcA-2cwlA:
undetectable		 5jlcA-2cwlA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d0v METHANOL
DEHYDROGENASE LARGE
SUBUNIT
METHANOL
DEHYDROGENASE SMALL
SUBUNIT

(Hyphomicrobium
denitrificans) 		PF01011
(PQQ)
PF02315
(MDH)
PF13360
(PQQ_2) 		4 TYR B   1
GLY B   3
THR B   4
GLY A 182
 None
 0.79A 5jlcA-2d0vB:
undetectable		 5jlcA-2d0vB:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ejw HOMOSERINE
DEHYDROGENASE

(Thermus
thermophilus) 		PF00742
(Homoserine_dh)
PF03447
(NAD_binding_3) 		4 GLY A 151
THR A 152
GLY A 325
LEU A 196
 NO3  A2602 (-3.2A)
NO3  A2602 (-4.4A)
None
None
 0.87A 5jlcA-2ejwA:
undetectable		 5jlcA-2ejwA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fp3 CASPASE NC

(Drosophila
melanogaster) 		PF00656
(Peptidase_C14) 		4 TYR A 389
THR A 429
GLY A 185
LEU A 368
 None
 0.93A 5jlcA-2fp3A:
undetectable		 5jlcA-2fp3A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fsr ACETYLTRANSFERASE

(Agrobacterium
fabrum) 		PF13302
(Acetyltransf_3) 		4 TYR A 165
GLY A 147
THR A 148
GLY A 100
 None
 0.81A 5jlcA-2fsrA:
undetectable		 5jlcA-2fsrA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gu1 ZINC PEPTIDASE

(Vibrio cholerae) 		PF01551
(Peptidase_M23)
PF04225
(OapA) 		4 GLY A 309
THR A 308
GLY A 295
LEU A 281
 None
 0.79A 5jlcA-2gu1A:
undetectable		 5jlcA-2gu1A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hdi COLICIN I RECEPTOR
COLICIN-IA

(Escherichia
coli) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug)
PF11504
(Colicin_Ia) 		4 GLY A 352
THR A 353
GLY B 310
LEU A 424
 None
 0.92A 5jlcA-2hdiA:
undetectable		 5jlcA-2hdiA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hrz NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE

(Agrobacterium
fabrum) 		PF01370
(Epimerase) 		4 TYR A 159
GLY A 160
THR A 161
GLY A 312
 None
 0.70A 5jlcA-2hrzA:
undetectable		 5jlcA-2hrzA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j6l ALDEHYDE
DEHYDROGENASE FAMILY
7 MEMBER A1

(Homo sapiens) 		PF00171
(Aldedh) 		4 GLY A 231
THR A 232
GLY A 482
LEU A 242
 NAI  A1501 (-3.4A)
NAI  A1501 (-4.3A)
None
None
 0.85A 5jlcA-2j6lA:
undetectable		 5jlcA-2j6lA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kh2 SCFV

(Mus musculus) 		PF07686
(V-set) 		4 TYR B 224
GLY B 241
THR B 242
GLY B 116
 None
 0.84A 5jlcA-2kh2B:
undetectable		 5jlcA-2kh2B:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pw6 UNCHARACTERIZED
PROTEIN YGID

(Escherichia
coli) 		PF02900
(LigB) 		4 GLY A 225
THR A 226
GLY A 247
LEU A 238
 None
 0.91A 5jlcA-2pw6A:
undetectable		 5jlcA-2pw6A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uvf EXOPOLYGALACTURONASE

(Yersinia
enterocolitica) 		PF00295
(Glyco_hydro_28)
PF12708
(Pectate_lyase_3) 		4 TYR A 230
GLY A 229
GLY A 265
LEU A 333
 None
 0.86A 5jlcA-2uvfA:
undetectable		 5jlcA-2uvfA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v4j SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT ALPHA
SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT BETA

(Desulfovibrio
vulgaris) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		4 GLY A 143
THR A 144
GLY B 125
LEU A  51
 None
 0.68A 5jlcA-2v4jA:
undetectable		 5jlcA-2v4jA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v5n CATION-INDEPENDENT
MANNOSE-6-PHOSPHATE
RECEPTOR

(Homo sapiens) 		PF00878
(CIMR) 		4 TYR A1592
GLY A1564
GLY A1619
LEU A1532
 None
 0.91A 5jlcA-2v5nA:
undetectable		 5jlcA-2v5nA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vqa SLL1358 PROTEIN

(Synechocystis
sp. PCC 6803) 		PF00190
(Cupin_1) 		4 GLY A 166
THR A 167
GLY A 297
LEU A 160
 None
 0.69A 5jlcA-2vqaA:
undetectable		 5jlcA-2vqaA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2waw MOBA RELATE PROTEIN

(Mycobacterium
sp. DSM 3803) 		PF12804
(NTP_transf_3) 		4 TYR A  15
GLY A  80
GLY A 165
LEU A 152
 CSO  A  81 (-4.2A)
CSO  A  81 (-2.4A)
None
None
 0.68A 5jlcA-2wawA:
undetectable		 5jlcA-2wawA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xdq LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT N

(Thermosynechococcus
elongatus) 		PF00148
(Oxidored_nitro) 		4 TYR A 355
THR A 257
GLY A 221
LEU A 201
 None
 0.88A 5jlcA-2xdqA:
undetectable		 5jlcA-2xdqA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsj SULFITE REDUCTASE
ALPHA SUBUNIT
SULFITE REDUCTASE
BETA SUBUNIT

(Desulfomicrobium
norvegicum) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr)
PF12838
(Fer4_7) 		4 GLY A 143
THR A 144
GLY B 125
LEU A  51
 None
 0.71A 5jlcA-2xsjA:
undetectable		 5jlcA-2xsjA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yfn ALPHA-GALACTOSIDASE-
SUCROSE KINASE AGASK

([Ruminococcus]
gnavus) 		PF02065
(Melibiase)
PF16874
(Glyco_hydro_36C)
PF16875
(Glyco_hydro_36N) 		4 TYR A 552
GLY A 553
THR A 554
GLY A 188
 None
None
None
GOL  A1722 ( 4.0A)
 0.70A 5jlcA-2yfnA:
undetectable		 5jlcA-2yfnA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z6g B-CATENIN

(Danio rerio) 		PF00514
(Arm) 		4 GLY A 574
THR A 573
GLY A 442
LEU A 516
 None
 0.92A 5jlcA-2z6gA:
undetectable		 5jlcA-2z6gA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z6v PUTATIVE
UNCHARACTERIZED
PROTEIN

(Mycobacterium
avium) 		PF13469
(Sulfotransfer_3) 		4 TYR A 368
GLY A 260
THR A 259
LEU A 268
 None
 0.93A 5jlcA-2z6vA:
undetectable		 5jlcA-2z6vA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zxq ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE

(Bifidobacterium
longum) 		PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C) 		4 GLY A1404
THR A1403
GLY A1281
LEU A1271
 None
 0.77A 5jlcA-2zxqA:
undetectable		 5jlcA-2zxqA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3akf PUTATIVE SECRETED
ALPHA
L-ARABINOFURANOSIDAS
E II

(Streptomyces
avermitilis) 		PF04616
(Glyco_hydro_43)
PF05270
(AbfB) 		4 GLY A  72
THR A  96
GLY A 259
LEU A 134
 None
 0.91A 5jlcA-3akfA:
undetectable		 5jlcA-3akfA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fdj DEGV FAMILY PROTEIN

([Eubacterium]
eligens) 		PF02645
(DegV) 		4 GLY A 116
THR A 115
GLY A 133
LEU A   3
 None
P6G  A 276 ( 3.7A)
None
None
 0.80A 5jlcA-3fdjA:
undetectable		 5jlcA-3fdjA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fpz THIAZOLE
BIOSYNTHETIC ENZYME

(Saccharomyces
cerevisiae) 		PF01946
(Thi4) 		4 GLY A 182
THR A 179
GLY A  72
LEU A 173
 None
None
AHZ  A1100 (-3.3A)
None
 0.78A 5jlcA-3fpzA:
undetectable		 5jlcA-3fpzA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fru BETA-2-MICROGLOBULIN
NEONATAL FC RECEPTOR

(Rattus
norvegicus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		4 GLY A 229
THR A 228
GLY B  43
LEU B  23
 None
 0.88A 5jlcA-3fruA:
undetectable		 5jlcA-3fruA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i4y CATECHOL
1,2-DIOXYGENASE

(Rhodococcus
opacus) 		PF00775
(Dioxygenase_C)
PF04444
(Dioxygenase_N) 		4 GLY A 176
THR A 177
GLY A 241
LEU A 132
 None
 0.83A 5jlcA-3i4yA:
undetectable		 5jlcA-3i4yA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k3q LLAMA AA1 VHH DOMAIN

(Lama glama) 		PF07686
(V-set) 		4 GLY A  13
THR A  14
GLY A 122
LEU A  95
 None
 0.86A 5jlcA-3k3qA:
undetectable		 5jlcA-3k3qA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kw7 LACCASE B

(Trametes sp.
AH28-2) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 GLY A 369
THR A 368
GLY A 434
LEU A 454
 None
 0.87A 5jlcA-3kw7A:
undetectable		 5jlcA-3kw7A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lmd GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Corynebacterium
glutamicum) 		PF00348
(polyprenyl_synt) 		4 GLY A 173
THR A 172
GLY A  72
LEU A 110
 None
 0.92A 5jlcA-3lmdA:
1.2		 5jlcA-3lmdA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o75 FRUCTOSE TRANSPORT
SYSTEM REPRESSOR
FRUR

(Pseudomonas
putida) 		PF00532
(Peripla_BP_1) 		4 GLY A 210
THR A 209
GLY A 274
LEU A 184
 None
None
F1X  A   1 (-3.1A)
None
 0.84A 5jlcA-3o75A:
1.1		 5jlcA-3o75A:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sqz PUTATIVE
HYDROXYMETHYLGLUTARY
L-COA SYNTHASE

(Streptococcus
mutans) 		PF00195
(Chal_sti_synt_N)
PF08540
(HMG_CoA_synt_C) 		4 GLY A 318
THR A 317
GLY A  57
LEU A 287
 None
 0.90A 5jlcA-3sqzA:
undetectable		 5jlcA-3sqzA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w4q BETA-LACTAMASE

(Burkholderia
multivorans) 		PF13354
(Beta-lactamase2) 		4 GLY A  55
THR A  54
GLY A 236
LEU A 190
 None
 0.92A 5jlcA-3w4qA:
undetectable		 5jlcA-3w4qA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zo9 TREHALOSE
SYNTHASE/AMYLASE
TRES

(Mycolicibacterium
smegmatis) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		4 GLY A 106
THR A 107
GLY A 419
LEU A  45
 None
CL  A1591 ( 4.7A)
None
CL  A1590 (-4.1A)
 0.91A 5jlcA-3zo9A:
undetectable		 5jlcA-3zo9A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyy IRON-SULFUR CLUSTER
BINDING PROTEIN

(Carboxydothermus
hydrogenoformans) 		PF00111
(Fer2)
PF14574
(DUF4445) 		4 GLY X 354
THR X 299
GLY X 228
LEU X 575
 None
 0.89A 5jlcA-3zyyX:
undetectable		 5jlcA-3zyyX:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ag4 MONOCLONAL ANTIBODY
3E3 HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 TYR H  91
GLY H 106
THR H 107
GLY H 162
 None
 0.88A 5jlcA-4ag4H:
undetectable		 5jlcA-4ag4H:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ap3 STEROID
MONOOXYGENASE

(Rhodococcus
rhodochrous) 		PF00743
(FMO-like) 		4 GLY A 375
THR A 374
GLY A  67
LEU A 217
 None
 0.89A 5jlcA-4ap3A:
undetectable		 5jlcA-4ap3A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c1n IRON-SULFUR CLUSTER
BINDING PROTEIN

(Carboxydothermus
hydrogenoformans) 		PF14574
(DUF4445) 		4 GLY I 354
THR I 299
GLY I 228
LEU I 575
 None
 0.84A 5jlcA-4c1nI:
undetectable		 5jlcA-4c1nI:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cok PYRUVATE
DECARBOXYLASE

(Gluconacetobacter
diazotrophicus) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 TYR A 347
GLY A 259
THR A 241
GLY A 435
 None
None
None
TPP  A 600 (-3.4A)
 0.84A 5jlcA-4cokA:
undetectable		 5jlcA-4cokA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d8o ANKYRIN-2

(Homo sapiens) 		PF00531
(Death)
PF00791
(ZU5) 		4 GLY A1234
THR A1235
GLY A1135
LEU A1189
 None
 0.90A 5jlcA-4d8oA:
undetectable		 5jlcA-4d8oA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4doi CHALCONE--FLAVONONE
ISOMERASE 1

(Arabidopsis
thaliana) 		PF02431
(Chalcone) 		4 GLY A 185
THR A 184
GLY A 207
LEU A 165
 None
 0.79A 5jlcA-4doiA:
undetectable		 5jlcA-4doiA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dq8 ACETATE KINASE

(Mycobacterium
marinum) 		PF00871
(Acetate_kinase) 		4 GLY A 170
THR A 171
GLY A 339
LEU A 196
 None
 0.93A 5jlcA-4dq8A:
undetectable		 5jlcA-4dq8A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e4g METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF00171
(Aldedh) 		4 GLY A  31
THR A  32
GLY A 273
LEU A  85
 None
 0.85A 5jlcA-4e4gA:
undetectable		 5jlcA-4e4gA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hbc ANTIGEN BINDING
FRAGMENT,
IMMUNOGLOBULIN IGG -
HEAVY CHAIN
ANTIGEN BINDING
FRAGMENT,
IMMUNOGLOBULIN IGG -
LIGHT CHAIN

(Oryctolagus
cuniculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 TYR L  87
GLY L 103
THR L 104
GLY H 176
 None
 0.92A 5jlcA-4hbcL:
undetectable		 5jlcA-4hbcL:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jy4 PGT121 HEAVY CHAIN
PGT121 LIGHT CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 TYR A  87
GLY A 101
THR A 102
GLY B 172
 None
 0.68A 5jlcA-4jy4A:
undetectable		 5jlcA-4jy4A:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kvf RHAMNOSE ABC
TRANSPORTER,
PERIPLASMIC
RHAMNOSE-BINDING
PROTEIN

(Kribbella
flavida) 		PF13407
(Peripla_BP_4) 		4 GLY A 323
THR A 322
GLY A  97
LEU A 135
 None
 0.79A 5jlcA-4kvfA:
undetectable		 5jlcA-4kvfA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o5m ISOVALERYL-COA
DEHYDROGENASE

(Brucella suis) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 GLY A 350
THR A 349
GLY A 160
LEU A 358
 None
 0.88A 5jlcA-4o5mA:
undetectable		 5jlcA-4o5mA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o9x TCDB2, TCCC3

(Photorhabdus
luminescens) 		PF03534
(SpvB)
PF12255
(TcdB_toxin_midC)
PF12256
(TcdB_toxin_midN) 		4 GLY A 502
THR A 518
GLY A 621
LEU A 558
 None
 0.78A 5jlcA-4o9xA:
undetectable		 5jlcA-4o9xA:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qiw DNA-DIRECTED RNA
POLYMERASE

(Thermococcus
kodakarensis) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		4 GLY B 460
THR B 461
GLY B 951
LEU B 650
 None
 0.91A 5jlcA-4qiwB:
undetectable		 5jlcA-4qiwB:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rav SINGLE-CHAIN FV, VH
SINGLE-CHAIN FV, VL

(Homo sapiens) 		PF07686
(V-set) 		4 TYR B 216
GLY B 230
THR B 231
GLY A 118
 None
 0.88A 5jlcA-4ravB:
undetectable		 5jlcA-4ravB:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s12 N-ACETYLMURAMIC ACID
6-PHOSPHATE ETHERASE

(Yersinia
enterocolitica) 		PF01380
(SIS) 		4 TYR A 290
GLY A 289
GLY A  77
LEU A  59
 None
 0.87A 5jlcA-4s12A:
0.7		 5jlcA-4s12A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y63 HISTO-BLOOD GROUP
ABO SYSTEM
TRANSFERASE

(Homo sapiens) 		PF03414
(Glyco_transf_6) 		4 GLY A 167
THR A 166
GLY A 230
LEU A 118
 None
 0.92A 5jlcA-4y63A:
undetectable		 5jlcA-4y63A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ydj HEAVY CHAIN OF
ANTIBODY 44-VRC13.01
LIGHT CHAIN OF
ANTIBODY 44-VRC13.01

(Homo sapiens) 		no annotation 4 TYR L  87
GLY L 101
THR L 102
GLY H 174
 None
 0.92A 5jlcA-4ydjL:
undetectable		 5jlcA-4ydjL:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yjf D-AMINO-ACID OXIDASE

(Sus scrofa) 		PF01266
(DAO) 		4 GLY B 240
THR B 241
GLY B 113
LEU B  51
 None
 0.87A 5jlcA-4yjfB:
undetectable		 5jlcA-4yjfB:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z0b ANTIBODY HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 TYR H  95
GLY H 115
THR H 116
GLY H 170
 None
 0.92A 5jlcA-4z0bH:
undetectable		 5jlcA-4z0bH:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zzq CELLULOSE
1,4-BETA-CELLOBIOSID
ASE

(Dictyostelium
discoideum) 		PF00840
(Glyco_hydro_7) 		4 GLY A 152
THR A 168
GLY A 430
LEU A 145
 None
 0.91A 5jlcA-4zzqA:
undetectable		 5jlcA-4zzqA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ap9 LIPASE

(Thermomyces
lanuginosus) 		PF01764
(Lipase_3)
PF03893
(Lipase3_N) 		4 GLY A 191
THR A 192
GLY A  59
LEU A  78
 None
GOL  A 401 (-3.8A)
None
None
 0.91A 5jlcA-5ap9A:
undetectable		 5jlcA-5ap9A:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5awn HEAVY CHAIN OF
3BC176 FAB
LIGHT CHAIN OF
3BC176 FAB

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 TYR L  87
GLY L 101
THR L 102
GLY H 174
 None
 0.80A 5jlcA-5awnL:
undetectable		 5jlcA-5awnL:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b3v BILIVERDIN REDUCTASE

(Synechocystis
sp. PCC 6803) 		no annotation 4 GLY B 264
THR B 263
GLY B 228
LEU B 144
 None
 0.91A 5jlcA-5b3vB:
undetectable		 5jlcA-5b3vB:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5equ SNON,SNON

(Streptomyces
nogalater) 		PF05721
(PhyH) 		4 GLY A 142
THR A 143
GLY A  65
LEU A 246
 None
 0.93A 5jlcA-5equA:
undetectable		 5jlcA-5equA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fn4 NICASTRIN

(Homo sapiens) 		PF05450
(Nicastrin) 		4 GLY A 576
THR A 577
GLY A 549
LEU A 538
 None
 0.81A 5jlcA-5fn4A:
0.7		 5jlcA-5fn4A:
21.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fsa CYP51 VARIANT1

(Candida
albicans) 		PF00067
(p450) 		4 TYR A  64
GLY A  65
GLY A 303
LEU A 376
 None
X2N  A 590 ( 4.0A)
X2N  A 590 ( 4.8A)
X2N  A 590 (-4.3A)
 0.47A 5jlcA-5fsaA:
54.7		 5jlcA-5fsaA:
62.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5giu PROLINE DIPEPTIDASE

(Deinococcus
radiodurans) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		4 TYR A 218
GLY A 217
GLY A  90
LEU A  30
 None
 0.83A 5jlcA-5giuA:
undetectable		 5jlcA-5giuA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5glg FUMARATE REDUCTASE 2

(Saccharomyces
cerevisiae) 		PF00890
(FAD_binding_2) 		4 GLY A 148
THR A 325
GLY A 159
LEU A 306
 None
 0.90A 5jlcA-5glgA:
undetectable		 5jlcA-5glgA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i2h O-METHYLTRANSFERASE
FAMILY 2

(Planctopirus
limnophila) 		PF00891
(Methyltransf_2)
PF16864
(Dimerisation2) 		4 GLY A 307
THR A 306
GLY A 202
LEU A 318
 None
 0.73A 5jlcA-5i2hA:
undetectable		 5jlcA-5i2hA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j13 ANTI-TSLP
FAB-FRAGMENT, HEAVY
CHAIN
ANTI-TSLP
FAB-FRAGMENT, LIGHT
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 TYR B  89
GLY B 105
THR B 106
GLY C 186
 None
 0.85A 5jlcA-5j13B:
undetectable		 5jlcA-5j13B:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jh8 PROBABLE CHITINASE

(Chromobacterium
violaceum) 		PF00704
(Glyco_hydro_18) 		4 TYR A 219
GLY A 218
THR A 271
GLY A  63
 6KY  A 504 (-3.7A)
None
None
None
 0.72A 5jlcA-5jh8A:
undetectable		 5jlcA-5jh8A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jpn COMPLEMENT C4-A

(Homo sapiens) 		PF01759
(NTR)
PF07677
(A2M_recep) 		4 TYR C1737
GLY C1738
THR C1739
GLY C1697
 None
 0.62A 5jlcA-5jpnC:
undetectable		 5jlcA-5jpnC:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mdx CHLOROPHYLL A-B
BINDING PROTEIN
CP26, CHLOROPLASTIC
PHOTOSYSTEM II CP43
REACTION CENTER
PROTEIN

(Arabidopsis
thaliana) 		PF00421
(PSII)
PF00504
(Chloroa_b-bind) 		4 TYR C 131
GLY C 136
GLY S  87
LEU S  76
 CLA  S 301 (-4.0A)
None
None
None
 0.88A 5jlcA-5mdxC:
undetectable		 5jlcA-5mdxC:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mrw POTASSIUM-TRANSPORTI
NG ATPASE
ATP-BINDING SUBUNIT

(Escherichia
coli) 		PF00122
(E1-E2_ATPase)
PF00702
(Hydrolase) 		4 GLY B 519
THR B 520
GLY B 510
LEU B 305
 None
 0.74A 5jlcA-5mrwB:
undetectable		 5jlcA-5mrwB:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ncc FATTY ACID
PHOTODECARBOXYLASE

(Chlorella
variabilis) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		4 TYR A 515
GLY A 514
GLY A  90
LEU A 142
 None
None
FAD  A 701 (-3.4A)
None
 0.77A 5jlcA-5nccA:
0.4		 5jlcA-5nccA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nv3 RIBULOSE
BISPHOSPHATE
CARBOXYLASE LARGE
CHAIN

(Rhodobacter
sphaeroides) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 GLY A 247
THR A 248
GLY A 309
LEU A 271
 None
 0.76A 5jlcA-5nv3A:
undetectable		 5jlcA-5nv3A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oko PHOSPHATIDYLINOSITOL
3,4,5-TRISPHOSPHATE
5-PHOSPHATASE 2

(Homo sapiens) 		PF03372
(Exo_endo_phos) 		4 TYR A 707
GLY A 723
THR A 724
GLY A 860
 None
 0.93A 5jlcA-5okoA:
undetectable		 5jlcA-5okoA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wnn PHOSPHATE-BINDING
PROTEIN PSTS

(Burkholderia
pseudomallei) 		PF12849
(PBP_like_2) 		4 GLY A 234
THR A 233
GLY A 107
LEU A 115
 None
 0.93A 5jlcA-5wnnA:
undetectable		 5jlcA-5wnnA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wp6 TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY M
MEMBER 4

(Homo sapiens) 		no annotation 4 TYR A 229
GLY A 187
GLY A 303
LEU A 142
 None
 0.86A 5jlcA-5wp6A:
undetectable		 5jlcA-5wp6A:
9.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xeo CYSTEINE SYNTHASE

(Fusobacterium
nucleatum) 		no annotation 4 TYR A 232
GLY A 178
THR A 177
LEU A 241
 None
PLP  A 401 (-3.3A)
PLP  A 401 (-2.8A)
None
 0.75A 5jlcA-5xeoA:
undetectable		 5jlcA-5xeoA:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xm3 GLUCOSE
DEHYDROGENASE
METHANOL
DEHYDROGENASE
[CYTOCHROME C]
SUBUNIT 2

(Methylophaga
aminisulfidivorans) 		no annotation 4 TYR B  25
GLY B  27
THR B  28
GLY A 213
 None
 0.77A 5jlcA-5xm3B:
undetectable		 5jlcA-5xm3B:
8.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zc3 -

(-) 		no annotation 4 GLY B 194
THR B 195
GLY B 178
LEU B 188
 None
 0.93A 5jlcA-5zc3B:
undetectable		 5jlcA-5zc3B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eq8 PERIPLASMIC
ALPHA-GALACTOSIDE-BI
NDING PROTEIN

(Agrobacterium
tumefaciens) 		no annotation 4 TYR D 294
GLY D 273
GLY D 631
LEU D 649
 None
 0.83A 5jlcA-6eq8D:
undetectable		 5jlcA-6eq8D:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fb3 TENEURIN-2

(Gallus gallus) 		no annotation 4 TYR A2010
GLY A2009
THR A1745
LEU A2704
 None
 0.91A 5jlcA-6fb3A:
undetectable		 5jlcA-6fb3A:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
8fab IGG1-LAMBDA HIL FAB
(HEAVY CHAIN)
IGG1-LAMBDA HIL FAB
(LIGHT CHAIN)

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 TYR A  86
GLY A 100
THR A 101
GLY B 182
 None
 0.90A 5jlcA-8fabA:
undetectable		 5jlcA-8fabA:
17.41