SIMILAR PATTERNS OF AMINO ACIDS FOR 5JKW_A_TESA601_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bpo PROTEIN (CLATHRIN)

(Rattus
norvegicus) 		PF01394
(Clathrin_propel)
PF09268
(Clathrin-link)
PF13838
(Clathrin_H_link) 		5 ILE A  52
ILE A  40
THR A  31
VAL A  79
LEU A  82
 None
 1.46A 5jkwA-1bpoA:
0.0		 5jkwA-1bpoA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gff BACTERIOPHAGE G4
CAPSID PROTEINS GPF,
GPG, GPJ

(Escherichia
virus G4) 		PF02306
(Phage_G) 		5 ILE 2  75
PHE 2 124
ILE 2  91
VAL 2 160
LEU 2 147
 None
 1.28A 5jkwA-1gff2:
undetectable		 5jkwA-1gff2:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i31 CLATHRIN COAT
ASSEMBLY PROTEIN
AP50

(Rattus
norvegicus) 		PF00928
(Adap_comp_sub) 		5 ILE A 263
PHE A 265
VAL A 401
MET A 202
LEU A 404
 None
 1.20A 5jkwA-1i31A:
0.0		 5jkwA-1i31A:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ih5 AQUAPORIN-1

(Homo sapiens) 		PF00230
(MIP) 		5 ASP A 158
THR A 157
VAL A 153
VAL A  79
LEU A 151
 None
 1.45A 5jkwA-1ih5A:
0.0		 5jkwA-1ih5A:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ijq LOW-DENSITY
LIPOPROTEIN RECEPTOR

(Homo sapiens) 		PF00058
(Ldl_recept_b)
PF14670
(FXa_inhibition) 		5 ASP A 481
THR A 482
VAL A 460
VAL A 503
MET A 510
 None
 1.46A 5jkwA-1ijqA:
0.0		 5jkwA-1ijqA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jx2 MYOSIN-2 HEAVY
CHAIN,DYNAMIN-A

(Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		5 ILE A 990
PHE A1017
THR A 965
VAL A1010
LEU A 973
 None
 1.29A 5jkwA-1jx2A:
0.0		 5jkwA-1jx2A:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lbq FERROCHELATASE

(Saccharomyces
cerevisiae) 		PF00762
(Ferrochelatase) 		5 ILE A 191
THR A 145
VAL A  42
VAL A 158
LEU A 178
 None
 1.30A 5jkwA-1lbqA:
0.0		 5jkwA-1lbqA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m4x PBCV-1 VIRUS CAPSID

(Paramecium
bursaria
Chlorella virus
1) 		PF04451
(Capsid_NCLDV)
PF16903
(Capsid_N) 		5 PHE A  74
ILE A  70
THR A  58
VAL A  56
VAL A  50
 None
 1.40A 5jkwA-1m4xA:
0.0		 5jkwA-1m4xA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nxj PROBABLE
S-ADENOSYLMETHIONINE
:2-DEMETHYLMENAQUINO
NE METHYLTRANSFERASE

(Mycobacterium
tuberculosis) 		PF03737
(RraA-like) 		5 ILE A 112
ILE A 108
VAL A  63
VAL A  65
LEU A  55
 None
 1.31A 5jkwA-1nxjA:
undetectable		 5jkwA-1nxjA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pfx FACTOR IXA

(Sus scrofa) 		PF00089
(Trypsin) 		5 ILE C  64
ILE C  59
THR C  54
VAL C  67
LEU C 108
 None
 1.41A 5jkwA-1pfxC:
undetectable		 5jkwA-1pfxC:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t0h VOLTAGE-GATED
CALCIUM CHANNEL
SUBUNIT BETA2A

(Rattus
norvegicus) 		PF12052
(VGCC_beta4Aa_N) 		5 ILE A  85
ASP A  91
THR A  66
VAL A  64
VAL A  95
 None
 1.17A 5jkwA-1t0hA:
undetectable		 5jkwA-1t0hA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tll NITRIC-OXIDE
SYNTHASE, BRAIN

(Rattus
norvegicus) 		PF00175
(NAD_binding_1)
PF00258
(Flavodoxin_1)
PF00667
(FAD_binding_1) 		5 ILE A1156
PHE A1112
VAL A1147
MET A1146
LEU A1163
 None
 1.20A 5jkwA-1tllA:
undetectable		 5jkwA-1tllA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wye 2-KETO-3-DEOXYGLUCON
ATE KINASE

(Sulfurisphaera
tokodaii) 		PF00294
(PfkB) 		5 ILE A 179
ILE A 165
ASP A 197
THR A 193
LEU A 202
 None
 1.24A 5jkwA-1wyeA:
undetectable		 5jkwA-1wyeA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xp3 ENDONUCLEASE IV

(Bacillus
anthracis) 		PF01261
(AP_endonuc_2) 		5 ILE A 191
PHE A 195
ASP A 180
THR A 147
LEU A 214
 None
None
ZN  A 303 ( 3.3A)
None
None
 1.15A 5jkwA-1xp3A:
undetectable		 5jkwA-1xp3A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zg4 BETA-LACTAMASE TEM

(Escherichia
coli) 		PF13354
(Beta-lactamase2) 		5 PHE A 151
ILE A  84
THR A 200
MET A 155
LEU A 193
 None
 1.13A 5jkwA-1zg4A:
undetectable		 5jkwA-1zg4A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zq1 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT D

(Pyrococcus
abyssi) 		PF00710
(Asparaginase) 		5 ILE A 334
ILE A 346
VAL A 358
VAL A 307
LEU A 324
 None
 1.45A 5jkwA-1zq1A:
undetectable		 5jkwA-1zq1A:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bp5 CLATHRIN COAT
ASSEMBLY PROTEIN
AP50

(Rattus
norvegicus) 		PF00928
(Adap_comp_sub) 		5 ILE M 263
PHE M 265
VAL M 401
MET M 202
LEU M 404
 None
 1.31A 5jkwA-2bp5M:
undetectable		 5jkwA-2bp5M:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c07 3-OXOACYL-(ACYL-CARR
IER PROTEIN)
REDUCTASE

(Plasmodium
falciparum) 		PF13561
(adh_short_C2) 		5 ILE A 197
THR A 223
VAL A 295
VAL A 297
LEU A 283
 None
 1.40A 5jkwA-2c07A:
undetectable		 5jkwA-2c07A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f28 SIALIDASE 2

(Homo sapiens) 		PF13088
(BNR_2) 		5 ILE A 191
ASP A 215
THR A 216
VAL A 244
LEU A 240
 None
 1.28A 5jkwA-2f28A:
undetectable		 5jkwA-2f28A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9z PROTEIN (CHEMOTAXIS
METHYLATION PROTEIN)

(Thermotoga
maritima) 		PF03975
(CheD) 		5 ILE C 157
ASP C 123
THR C 124
VAL C  45
LEU C  24
 None
 1.23A 5jkwA-2f9zC:
undetectable		 5jkwA-2f9zC:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iht CARBOXYETHYLARGININE
SYNTHASE

(Streptomyces
clavuligerus) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 ILE A 388
ILE A 406
VAL A 488
MET A 382
LEU A 539
 None
 1.46A 5jkwA-2ihtA:
undetectable		 5jkwA-2ihtA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j04 HYPOTHETICAL PROTEIN
YPL007C

(Saccharomyces
cerevisiae) 		PF12660
(zf-TFIIIC) 		5 ILE A 451
PHE A 454
ILE A 484
VAL A 552
LEU A 570
 None
 1.31A 5jkwA-2j04A:
undetectable		 5jkwA-2j04A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jgz G2/MITOTIC-SPECIFIC
CYCLIN-B1

(Homo sapiens) 		PF00134
(Cyclin_N)
PF02984
(Cyclin_C) 		5 ARG B 202
ILE B 230
ILE B 289
VAL B 187
VAL B 337
 None
 1.41A 5jkwA-2jgzB:
undetectable		 5jkwA-2jgzB:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ko1 GTP
PYROPHOSPHOKINASE

(Chlorobaculum
tepidum) 		PF13291
(ACT_4) 		5 ARG A  77
ILE A   8
ILE A  26
THR A  31
VAL A  53
 None
 1.32A 5jkwA-2ko1A:
undetectable		 5jkwA-2ko1A:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mf9 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP8

(Homo sapiens) 		PF00254
(FKBP_C) 		5 ILE A  96
THR A  72
VAL A 142
VAL A 103
LEU A  86
 None
 1.36A 5jkwA-2mf9A:
undetectable		 5jkwA-2mf9A:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pnm PROTEASE VP4

(Infectious
pancreatic
necrosis virus) 		PF01768
(Birna_VP4) 		5 ILE A 668
ILE A 665
VAL A 543
VAL A 545
LEU A 685
 None
 1.27A 5jkwA-2pnmA:
undetectable		 5jkwA-2pnmA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pyb NEUTROPHIL
ACTIVATING PROTEIN

(Borreliella
burgdorferi) 		PF00210
(Ferritin) 		5 PHE A  30
ILE A 142
ASP A 145
VAL A 110
LEU A  56
 None
 1.14A 5jkwA-2pybA:
undetectable		 5jkwA-2pybA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qjg PUTATIVE ALDOLASE
MJ0400

(Methanocaldococcus
jannaschii) 		PF01791
(DeoC) 		5 ILE A  83
THR A  27
VAL A 206
VAL A 183
MET A 151
 None
None
None
None
F2P  A 501 (-3.3A)
 1.43A 5jkwA-2qjgA:
undetectable		 5jkwA-2qjgA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qv3 VACUOLATING
CYTOTOXIN

(Helicobacter
pylori) 		PF02691
(VacA) 		5 ILE A 514
PHE A 512
ILE A 476
THR A 502
VAL A 559
 None
 0.93A 5jkwA-2qv3A:
undetectable		 5jkwA-2qv3A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r4j AEROBIC
GLYCEROL-3-PHOSPHATE
DEHYDROGENASE

(Escherichia
coli) 		PF01266
(DAO)
PF16901
(DAO_C) 		5 ILE A 234
ILE A 284
THR A 271
VAL A 256
VAL A 258
 None
None
None
13P  A1968 ( 4.5A)
None
 1.40A 5jkwA-2r4jA:
undetectable		 5jkwA-2r4jA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vhq NTPASE P4

(Pseudomonas
phage phi12) 		PF11602
(NTPase_P4) 		5 ASP A 189
VAL A 128
VAL A 126
MET A 125
LEU A 191
 MG  A1328 ( 4.5A)
None
None
None
None
 1.25A 5jkwA-2vhqA:
undetectable		 5jkwA-2vhqA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a45 FORMAMIDOPYRIMIDINE-
DNA GLYCOSYLASE

(Acanthamoeba
polyphaga
mimivirus) 		PF01149
(Fapy_DNA_glyco)
PF06831
(H2TH) 		5 ILE A 167
ILE A 145
VAL A 176
VAL A 158
LEU A 202
 None
 1.32A 5jkwA-3a45A:
undetectable		 5jkwA-3a45A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aal PROBABLE
ENDONUCLEASE 4

(Geobacillus
kaustophilus) 		PF01261
(AP_endonuc_2) 		5 ILE A 190
PHE A 194
ASP A 179
THR A 146
LEU A 213
 None
None
FE  A 302 ( 3.2A)
None
None
 1.21A 5jkwA-3aalA:
undetectable		 5jkwA-3aalA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bws PROTEIN LP49

(Leptospira
interrogans) 		PF10282
(Lactonase) 		5 ASP A 258
THR A 273
VAL A 261
VAL A 249
LEU A 232
 None
 1.34A 5jkwA-3bwsA:
undetectable		 5jkwA-3bwsA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d4o DIPICOLINATE
SYNTHASE SUBUNIT A

(Bacillus
halodurans) 		PF01262
(AlaDh_PNT_C)
PF16924
(DpaA_N) 		5 ILE A 220
THR A 249
VAL A 239
VAL A 215
LEU A 210
 None
 1.45A 5jkwA-3d4oA:
undetectable		 5jkwA-3d4oA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d6j PUTATIVE HALOACID
DEHALOGENASE-LIKE
HYDROLASE

(Bacteroides
fragilis) 		PF13419
(HAD_2) 		5 ILE A 132
PHE A 129
ILE A 108
MET A 124
LEU A  14
 None
 1.18A 5jkwA-3d6jA:
undetectable		 5jkwA-3d6jA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fg6 ADSEVERIN

(Homo sapiens) 		PF00626
(Gelsolin) 		5 ILE A 580
PHE A 589
VAL A 540
VAL A 542
LEU A 535
 None
 1.06A 5jkwA-3fg6A:
undetectable		 5jkwA-3fg6A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g7t ENVELOPE PROTEIN

(Dengue virus) 		PF00869
(Flavi_glycoprot)
PF02832
(Flavi_glycop_C) 		5 ILE A 270
ILE A 278
VAL A 130
VAL A 197
LEU A 191
 None
 1.13A 5jkwA-3g7tA:
undetectable		 5jkwA-3g7tA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ge6 NITROREDUCTASE

(Exiguobacterium
sibiricum) 		PF00881
(Nitroreductase) 		5 ILE A  84
ILE A  36
THR A  41
VAL A 184
MET A 185
 None
None
None
None
FMN  A 300 ( 4.6A)
 1.25A 5jkwA-3ge6A:
undetectable		 5jkwA-3ge6A:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0l GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A

(Aquifex
aeolicus) 		PF01425
(Amidase) 		5 ILE A 223
ILE A 101
VAL A 162
VAL A 216
LEU A  64
 None
 1.31A 5jkwA-3h0lA:
undetectable		 5jkwA-3h0lA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j70 ENVELOPE
GLYCOPROTEIN GP120

(Human
immunodeficiency
virus 1) 		PF00516
(GP120) 		5 ILE D 491
TRP D  45
VAL D  84
VAL D 245
LEU D  86
 None
 1.42A 5jkwA-3j70D:
undetectable		 5jkwA-3j70D:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m0c LOW-DENSITY
LIPOPROTEIN RECEPTOR

(Homo sapiens) 		PF00057
(Ldl_recept_a)
PF00058
(Ldl_recept_b)
PF07645
(EGF_CA)
PF14670
(FXa_inhibition) 		5 ASP C 481
THR C 482
VAL C 460
VAL C 503
MET C 510
 None
 1.46A 5jkwA-3m0cC:
undetectable		 5jkwA-3m0cC:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mtw L-ARGININE
CARBOXYPEPTIDASE
CC2672

(Caulobacter
vibrioides) 		PF01979
(Amidohydro_1) 		5 ILE A 371
ILE A 400
THR A 412
VAL A 361
MET A 360
 None
 1.36A 5jkwA-3mtwA:
undetectable		 5jkwA-3mtwA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nip 3-GUANIDINOPROPIONAS
E

(Pseudomonas
aeruginosa) 		PF00491
(Arginase) 		5 ILE A 132
PHE A 133
ILE A 105
VAL A 237
MET A 144
 None
 1.34A 5jkwA-3nipA:
undetectable		 5jkwA-3nipA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oy2 GLYCOSYLTRANSFERASE
B736L

(Paramecium
bursaria
Chlorella virus
NY2A) 		no annotation 5 ILE A 128
PHE A 129
ILE A  92
ASP A  90
LEU A 116
 None
 1.18A 5jkwA-3oy2A:
undetectable		 5jkwA-3oy2A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qgv ALPHA AMYLASE

(Pyrococcus
woesei) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		5 ILE A 107
PHE A 197
ILE A 192
VAL A 207
LEU A 212
 None
None
None
None
SUC  A 702 (-3.7A)
 1.21A 5jkwA-3qgvA:
undetectable		 5jkwA-3qgvA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qxb PUTATIVE XYLOSE
ISOMERASE

(Rhodospirillum
rubrum) 		PF01261
(AP_endonuc_2) 		5 PHE A  82
THR A 185
VAL A 189
VAL A 158
MET A 114
 None
 1.44A 5jkwA-3qxbA:
undetectable		 5jkwA-3qxbA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r4v PUTATIVE
UNCHARACTERIZED
PROTEIN

(Pseudomonas
phage 201phi2-1) 		PF00091
(Tubulin) 		5 ILE A 213
ASP A 262
THR A 261
VAL A 179
LEU A 232
 None
 1.33A 5jkwA-3r4vA:
undetectable		 5jkwA-3r4vA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r9b CYTOCHROME P450
164A2

(Mycolicibacterium
smegmatis) 		PF00067
(p450) 		5 PHE A  99
THR A 260
VAL A 303
VAL A 306
LEU A 184
 None
HEM  A 501 (-3.4A)
HEM  A 501 (-4.7A)
D12  A 509 ( 4.5A)
D12  A 509 ( 4.3A)
 0.98A 5jkwA-3r9bA:
30.0		 5jkwA-3r9bA:
25.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s7i ALLERGEN ARA H 1,
CLONE P41B

(Arachis
hypogaea) 		PF00190
(Cupin_1) 		5 ILE A 235
PHE A 531
ILE A 398
VAL A 285
VAL A 215
 None
 1.29A 5jkwA-3s7iA:
undetectable		 5jkwA-3s7iA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t8i PURINE NUCLEOSIDASE,
(IUNH-2)

(Sulfolobus
solfataricus) 		PF01156
(IU_nuc_hydro) 		5 ILE A 121
ASP A  14
THR A  15
VAL A 217
LEU A 221
 CA  A 400 ( 4.8A)
CA  A 400 (-2.3A)
None
None
None
 1.39A 5jkwA-3t8iA:
undetectable		 5jkwA-3t8iA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vc7 PUTATIVE
OXIDOREDUCTASE

(Sinorhizobium
meliloti) 		PF13561
(adh_short_C2) 		5 ARG A 122
ILE A  68
ILE A  62
THR A  37
LEU A  85
 None
 1.23A 5jkwA-3vc7A:
undetectable		 5jkwA-3vc7A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x05 PHOSPHATIDYLINOSITOL
5-PHOSPHATE 4-KINASE
TYPE-2 BETA

(Homo sapiens) 		PF01504
(PIP5K) 		5 ARG A 146
PHE A 147
ILE A  54
ASP A 114
VAL A 346
 None
 1.39A 5jkwA-3x05A:
undetectable		 5jkwA-3x05A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a0k CULLIN-4A

(Homo sapiens) 		PF00888
(Cullin)
PF10557
(Cullin_Nedd8) 		5 ILE A 376
PHE A 380
TRP A 340
VAL A 316
LEU A 311
 None
 1.24A 5jkwA-4a0kA:
undetectable		 5jkwA-4a0kA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4awd BETA-PORPHYRANASE

(Bacteroides
plebeius) 		no annotation 5 ILE A 279
TRP A  65
THR A 135
VAL A 282
LEU A  93
 None
None
None
GOL  A1322 ( 4.8A)
None
 1.36A 5jkwA-4awdA:
undetectable		 5jkwA-4awdA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b2q ATP SYNTHASE SUBUNIT
BETA, MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N) 		5 ILE D 296
ILE D 258
THR D 185
VAL D 183
VAL D 251
 None
 0.90A 5jkwA-4b2qD:
undetectable		 5jkwA-4b2qD:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ct3 ORF30/ORF32

(Staphylococcus
virus K) 		PF05257
(CHAP) 		5 ILE A 159
ILE A 118
THR A  72
VAL A  70
LEU A  65
 None
CMH  A1166 (-4.7A)
None
None
None
 1.21A 5jkwA-4ct3A:
undetectable		 5jkwA-4ct3A:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dxb MALTOSE-BINDING
PERIPLASMIC PROTEIN,
BETA-LACTAMASE TEM
CHIMERA

(Escherichia
coli) 		PF01547
(SBP_bac_1)
PF13354
(Beta-lactamase2) 		5 PHE A 507
ILE A 440
THR A 556
MET A 511
LEU A 549
 None
 1.03A 5jkwA-4dxbA:
undetectable		 5jkwA-4dxbA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ej0 ADP-L-GLYCERO-D-MANN
O-HEPTOSE-6-EPIMERAS
E

(Burkholderia
thailandensis) 		PF01370
(Epimerase) 		5 ILE A   4
PHE A  66
ILE A  28
VAL A  58
LEU A  52
 None
 1.33A 5jkwA-4ej0A:
undetectable		 5jkwA-4ej0A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f52 GLOMULIN

(Homo sapiens) 		PF08568
(Kinetochor_Ybp2) 		5 ILE E 501
PHE E 505
ILE E 579
VAL E 453
LEU E 475
 None
 1.34A 5jkwA-4f52E:
undetectable		 5jkwA-4f52E:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fc7 PEROXISOMAL
2,4-DIENOYL-COA
REDUCTASE

(Homo sapiens) 		PF13561
(adh_short_C2) 		5 ILE A 163
THR A 189
VAL A 264
VAL A 266
LEU A 252
 NAP  A 401 (-4.6A)
None
None
None
None
 1.29A 5jkwA-4fc7A:
undetectable		 5jkwA-4fc7A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fwt ELONGATION FACTOR
TS, ELONGATION
FACTOR TU, LINKER, Q
BETA REPLICASE

(Escherichia
coli;
Escherichia
virus Qbeta) 		PF00009
(GTP_EFTU)
PF00889
(EF_TS)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2)
PF03431
(RNA_replicase_B) 		5 ASP A1255
THR A1189
VAL A1187
VAL A1185
LEU A 709
 None
 1.40A 5jkwA-4fwtA:
undetectable		 5jkwA-4fwtA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g79 SPINDLE ASSEMBLY
ABNORMAL PROTEIN 6

(Caenorhabditis
elegans) 		PF16531
(SAS-6_N) 		5 ILE A  55
PHE A  65
ILE A 105
THR A  32
LEU A 109
 None
None
None
PG4  A 205 (-4.6A)
None
 1.07A 5jkwA-4g79A:
undetectable		 5jkwA-4g79A:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gip FUSION GLYCOPROTEIN
F1
FUSION GLYCOPROTEIN
F2

(Mammalian
rubulavirus 5) 		PF00523
(Fusion_gly) 		5 ILE D 273
VAL D 165
VAL A  50
MET D 269
LEU D 227
 None
 1.28A 5jkwA-4gipD:
undetectable		 5jkwA-4gipD:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igm 2-AMINO-3-CARBOXYMUC
ONATE-6-SEMIALDEHYDE
DECARBOXYLASE

(Homo sapiens) 		PF04909
(Amidohydro_2) 		5 ILE A 287
PHE A 327
ASP A   4
VAL A 173
LEU A 114
 None
 1.42A 5jkwA-4igmA:
undetectable		 5jkwA-4igmA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jga 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Rickettsia
rickettsii) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 PHE A 244
ILE A 353
VAL A 208
VAL A 213
LEU A 357
 None
 1.15A 5jkwA-4jgaA:
undetectable		 5jkwA-4jgaA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4knh NUP192P

(Chaetomium
thermophilum) 		PF11894
(Nup192) 		5 ILE A 555
PHE A 556
TRP A 552
VAL A 651
LEU A 620
 None
 1.21A 5jkwA-4knhA:
undetectable		 5jkwA-4knhA:
20.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4kq8 CYTOCHROME P450 19A1

(Homo sapiens) 		PF00067
(p450) 		11 ARG A 115
ILE A 133
PHE A 134
TRP A 224
ILE A 305
ASP A 309
THR A 310
VAL A 370
VAL A 373
MET A 374
LEU A 477
 HEM  A 601 ( 2.6A)
ASD  A 602 (-4.0A)
None
None
ASD  A 602 ( 4.7A)
ASD  A 602 (-3.8A)
ASD  A 602 (-3.9A)
HEM  A 601 (-4.4A)
ASD  A 602 (-4.0A)
ASD  A 602 (-4.3A)
ASD  A 602 (-4.5A)
 0.22A 5jkwA-4kq8A:
64.4		 5jkwA-4kq8A:
92.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4krg PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1

(Haemonchus
contortus) 		PF08241
(Methyltransf_11) 		5 ILE A 389
VAL A 322
VAL A 294
MET A 369
LEU A 352
 None
 1.35A 5jkwA-4krgA:
undetectable		 5jkwA-4krgA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lsb LYASE/MUTASE

(Burkholderia
cenocepacia) 		PF13714
(PEP_mutase) 		5 ILE A 190
ILE A 171
THR A 200
VAL A 228
VAL A 231
 None
 1.42A 5jkwA-4lsbA:
undetectable		 5jkwA-4lsbA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r16 418AA LONG
HYPOTHETICAL
UDP-N-ACETYL-D-MANNO
SAMINURONIC ACID
DEHYDROGENASE

(Pyrococcus
horikoshii) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		5 ILE A 336
PHE A 333
VAL A 341
VAL A 344
LEU A 295
 None
 1.42A 5jkwA-4r16A:
undetectable		 5jkwA-4r16A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rlt (3R)-HYDROXYACYL-ACP
DEHYDRATASE SUBUNIT
HADA

(Mycobacterium
tuberculosis) 		PF13452
(MaoC_dehydrat_N) 		5 PHE A  71
ILE A  84
VAL A 112
VAL A   8
MET A  10
 None
 1.46A 5jkwA-4rltA:
undetectable		 5jkwA-4rltA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rlv ANKYRIN-1, ANKYRIN-2

(Homo sapiens;
Mus musculus) 		PF00023
(Ank)
PF12796
(Ank_2)
PF13637
(Ank_4)
PF13857
(Ank_5) 		5 ASP A2204
THR A2205
VAL A2226
MET A2225
LEU A2211
 None
 1.47A 5jkwA-4rlvA:
undetectable		 5jkwA-4rlvA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rs3 ABC TRANSPORTER,
CARBOHYDRATE UPTAKE
TRANSPORTER-2 (CUT2)
FAMILY, PERIPLASMIC
SUGAR-BINDING
PROTEIN

(Mycolicibacterium
smegmatis) 		PF13407
(Peripla_BP_4) 		5 ILE A  93
ILE A  86
ASP A  83
VAL A  41
LEU A 103
 None
 1.30A 5jkwA-4rs3A:
undetectable		 5jkwA-4rs3A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rs3 ABC TRANSPORTER,
CARBOHYDRATE UPTAKE
TRANSPORTER-2 (CUT2)
FAMILY, PERIPLASMIC
SUGAR-BINDING
PROTEIN

(Mycolicibacterium
smegmatis) 		PF13407
(Peripla_BP_4) 		5 ILE A  93
ILE A  86
ASP A  83
VAL A  96
LEU A 103
 None
 1.43A 5jkwA-4rs3A:
undetectable		 5jkwA-4rs3A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rsm PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR

(Mycolicibacterium
smegmatis) 		PF13407
(Peripla_BP_4) 		5 ILE A  93
ILE A  86
ASP A  83
VAL A  96
LEU A 103
 None
 1.44A 5jkwA-4rsmA:
undetectable		 5jkwA-4rsmA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ybg PROTEIN MAELSTROM

(Drosophila
melanogaster) 		PF13017
(Maelstrom) 		5 ILE A 193
ILE A 151
THR A 301
VAL A 305
VAL A 111
 None
 1.42A 5jkwA-4ybgA:
undetectable		 5jkwA-4ybgA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z79 LEIOMODIN-1
ACTIN-BINDING SITE 2
(ABS2)

(Homo sapiens) 		no annotation 5 ILE A 379
ILE A 399
THR A 369
VAL A 337
VAL A 335
 None
None
None
GOL  A 501 ( 4.8A)
GOL  A 501 (-3.9A)
 1.07A 5jkwA-4z79A:
undetectable		 5jkwA-4z79A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zi9 MCG133388, ISOFORM
CRA_T

(Mus musculus) 		PF00028
(Cadherin)
PF08266
(Cadherin_2) 		5 PHE A 253
ASP A 267
VAL A 236
MET A 289
LEU A 273
 None
 1.38A 5jkwA-4zi9A:
undetectable		 5jkwA-4zi9A:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a11 THIOCYANATE FORMING
PROTEIN

(Thlaspi arvense) 		PF01344
(Kelch_1) 		5 ILE A 262
PHE A 251
THR A 239
VAL A 224
VAL A 198
 None
 1.43A 5jkwA-5a11A:
undetectable		 5jkwA-5a11A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5anb EUKARYOTIC
TRANSLATION
INITIATION FACTOR 6

(Dictyostelium
discoideum) 		PF01912
(eIF-6) 		5 ILE I  97
ASP I 131
VAL I 137
VAL I 117
LEU I 133
 None
 1.32A 5jkwA-5anbI:
undetectable		 5jkwA-5anbI:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aqa OFF7_DB04V3

(synthetic
construct) 		PF00023
(Ank)
PF12796
(Ank_2)
PF13354
(Beta-lactamase2) 		5 PHE A 281
ILE A 214
THR A 330
MET A 285
LEU A 323
 None
 1.05A 5jkwA-5aqaA:
undetectable		 5jkwA-5aqaA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cx8 LIPOPROTEIN RAGB

(Porphyromonas
gingivalis) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		5 ASP A  77
THR A  74
VAL A 322
VAL A 354
LEU A  66
 None
 1.44A 5jkwA-5cx8A:
undetectable		 5jkwA-5cx8A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h9x BETA-1,3-GLUCANASE

(Paenibacillus
barengoltzii) 		PF16483
(Glyco_hydro_64) 		5 ARG A 261
ILE A  98
ILE A 258
VAL A 263
LEU A 407
 None
 1.34A 5jkwA-5h9xA:
undetectable		 5jkwA-5h9xA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hst POLYKETIDE SYNTHASE
TYPE I

(Bacillus
amyloliquefaciens) 		PF14765
(PS-DH) 		5 ILE A  59
ILE A  97
THR A 112
VAL A  53
LEU A  36
 None
 1.13A 5jkwA-5hstA:
undetectable		 5jkwA-5hstA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j1b CELL WALL ASSEMBLY
REGULATOR SMI1

(Saccharomyces
cerevisiae) 		PF09346
(SMI1_KNR4) 		5 ILE A 241
PHE A 159
ILE A 277
VAL A 136
LEU A 285
 None
 1.23A 5jkwA-5j1bA:
undetectable		 5jkwA-5j1bA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jri PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE

(Synechocystis
sp. PCC 6803) 		no annotation 5 ILE A 128
ILE A 315
THR A 124
VAL A 108
VAL A  96
 None
None
None
None
FAD  A 401 (-3.7A)
 1.43A 5jkwA-5jriA:
undetectable		 5jkwA-5jriA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxk ASP/GLU-SPECIFIC
DIPEPTIDYL-PEPTIDASE

(Porphyromonas
endodontalis) 		PF10459
(Peptidase_S46) 		5 ILE A 699
PHE A 698
ASP A 615
VAL A 601
MET A 637
 None
 1.29A 5jkwA-5jxkA:
undetectable		 5jkwA-5jxkA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxk ASP/GLU-SPECIFIC
DIPEPTIDYL-PEPTIDASE

(Porphyromonas
endodontalis) 		PF10459
(Peptidase_S46) 		5 ILE A 699
PHE A 698
ASP A 615
VAL A 601
VAL A 639
 None
 1.43A 5jkwA-5jxkA:
undetectable		 5jkwA-5jxkA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n4l CERULOPLASMIN

(Rattus
norvegicus) 		no annotation 5 ILE A 711
PHE A 799
ILE A 787
VAL A 714
LEU A 868
 None
 1.04A 5jkwA-5n4lA:
undetectable		 5jkwA-5n4lA:
9.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5njf METALLOPROTEASE TLDD

(Escherichia
coli) 		PF01523
(PmbA_TldD) 		5 PHE A 391
THR A 434
VAL A 472
VAL A 251
LEU A 427
 None
 1.46A 5jkwA-5njfA:
undetectable		 5jkwA-5njfA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oc9 -

(-) 		no annotation 5 ILE A  39
PHE A  52
VAL A 170
VAL A  20
LEU A  23
 None
 1.41A 5jkwA-5oc9A:
undetectable		 5jkwA-5oc9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5swv PENTAFUNCTIONAL AROM
POLYPEPTIDE

(Schizosaccharomyces
pombe) 		PF01487
(DHquinase_I)
PF08501
(Shikimate_dh_N) 		5 ILE C1241
PHE C1243
ASP C1155
THR C1121
VAL C1262
 None
 1.41A 5jkwA-5swvC:
undetectable		 5jkwA-5swvC:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7s FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE

(Acinetobacter
baumannii) 		PF01116
(F_bP_aldolase) 		5 ILE A 276
ILE A 315
VAL A 230
MET A 231
LEU A 263
 None
 1.44A 5jkwA-5u7sA:
undetectable		 5jkwA-5u7sA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wrk AP-2 COMPLEX SUBUNIT
MU

(Rattus
norvegicus) 		no annotation 5 ILE A 263
PHE A 265
VAL A 401
MET A 202
LEU A 404
 None
 1.20A 5jkwA-5wrkA:
undetectable		 5jkwA-5wrkA:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wrl AP-2 COMPLEX SUBUNIT
MU

(Rattus
norvegicus) 		no annotation 5 ILE A 263
PHE A 265
VAL A 401
MET A 202
LEU A 404
 None
 1.28A 5jkwA-5wrlA:
undetectable		 5jkwA-5wrlA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x5h CYSTATHIONINE
BETA-LYASES/CYSTATHI
ONINE
GAMMA-SYNTHASES

(Corynebacterium
glutamicum) 		PF01053
(Cys_Met_Meta_PP) 		5 ILE A 268
PHE A 271
ILE A 365
THR A 324
LEU A 383
 None
 1.42A 5jkwA-5x5hA:
undetectable		 5jkwA-5x5hA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6caj TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT BETA

(Homo sapiens) 		no annotation 5 ILE C 165
ILE C 266
THR C 263
VAL C 225
LEU C 254
 None
None
None
C7B  C 401 (-4.3A)
None
 1.36A 5jkwA-6cajC:
undetectable		 5jkwA-6cajC:
10.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cv0 SPIKE GLYCOPROTEIN

(Avian
coronavirus) 		no annotation 5 ILE A 677
PHE A 771
VAL A 755
MET A 758
LEU A 923
 None
 1.43A 5jkwA-6cv0A:
undetectable		 5jkwA-6cv0A:
8.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gpl GDP-MANNOSE 4,6
DEHYDRATASE

(Homo sapiens) 		no annotation 5 ILE B 105
THR B 132
VAL B 190
VAL B 202
LEU B 199
 None
 1.35A 5jkwA-6gplB:
undetectable		 5jkwA-6gplB:
undetectable