SIMILAR PATTERNS OF AMINO ACIDS FOR 5JJ0_B_SAMB1205_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1peg HISTONE H3
METHYLTRANSFERASE
DIM-5

(Neurospora
crassa) 		PF00856
(SET)
PF05033
(Pre-SET) 		6 GLY A 160
TRP A 161
ASN A 241
HIS A 242
TYR A 283
CYH A 306
 SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 ( 2.3A)
 0.49A 5jj0B-1pegA:
25.8		 5jj0B-1pegA:
31.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1peg HISTONE H3
METHYLTRANSFERASE
DIM-5

(Neurospora
crassa) 		PF00856
(SET)
PF05033
(Pre-SET) 		6 GLY A 160
TRP A 161
ASN A 241
HIS A 242
TYR A 283
CYH A 308
 SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 (-2.2A)
 1.28A 5jj0B-1pegA:
25.8		 5jj0B-1pegA:
31.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h21 RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E

(Pisum sativum) 		PF00856
(SET)
PF09273
(Rubis-subs-bind) 		5 GLY A  81
SER A 221
ASN A 242
HIS A 243
TYR A 287
 SAM  A 801 (-3.7A)
SAM  A 801 (-4.3A)
SAM  A 801 (-2.9A)
SAM  A 801 (-4.9A)
SAM  A 801 (-4.8A)
 0.49A 5jj0B-2h21A:
5.8		 5jj0B-2h21A:
21.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2

(Homo sapiens) 		PF00856
(SET)
PF05033
(Pre-SET) 		6 GLY A 151
TRP A 152
ASN A 219
HIS A 220
TYR A 261
CYH A 287
 SAM  A 304 (-3.5A)
None
SAM  A 304 (-3.3A)
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
 0.33A 5jj0B-2r3aA:
28.1		 5jj0B-2r3aA:
35.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2

(Homo sapiens) 		PF00856
(SET)
PF05033
(Pre-SET) 		5 GLY A 151
TRP A 152
HIS A 220
TYR A 261
CYH A 289
 SAM  A 304 (-3.5A)
None
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
 1.44A 5jj0B-2r3aA:
28.1		 5jj0B-2r3aA:
35.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX

(Homo sapiens) 		PF00856
(SET) 		5 ASN A3906
HIS A3907
TYR A3944
PHE A3946
CYH A3957
 SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
None
ZN  A4970 ( 2.3A)
 0.76A 5jj0B-2w5zA:
12.2		 5jj0B-2w5zA:
26.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX

(Homo sapiens) 		PF00856
(SET) 		5 GLY A3840
ASN A3906
HIS A3907
TYR A3944
CYH A3957
 SAH  A4971 ( 3.7A)
SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
ZN  A4970 ( 2.3A)
 0.29A 5jj0B-2w5zA:
12.2		 5jj0B-2w5zA:
26.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX

(Homo sapiens) 		PF00856
(SET) 		5 GLY A3840
ASN A3906
HIS A3907
TYR A3944
CYH A3959
 SAH  A4971 ( 3.7A)
SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
ZN  A4970 (-2.3A)
 1.31A 5jj0B-2w5zA:
12.2		 5jj0B-2w5zA:
26.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR

(Homo sapiens) 		PF00856
(SET)
PF05033
(Pre-SET) 		7 GLY A 136
TRP A 137
ASN A 209
HIS A 210
TYR A 248
PHE A 286
CYH A 273
 SAH  A 305 (-3.8A)
None
SAH  A 305 (-3.4A)
None
SAH  A 305 (-4.9A)
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
 0.54A 5jj0B-3bo5A:
26.1		 5jj0B-3bo5A:
32.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR

(Homo sapiens) 		PF00856
(SET)
PF05033
(Pre-SET) 		5 GLY A 136
TRP A 137
HIS A 210
TYR A 248
CYH A 275
 SAH  A 305 (-3.8A)
None
None
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
 1.43A 5jj0B-3bo5A:
26.1		 5jj0B-3bo5A:
32.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR

(Homo sapiens) 		PF00856
(SET)
PF05033
(Pre-SET) 		5 GLY A 138
SER A 176
HIS A 210
TYR A 248
CYH A 273
 None
SAH  A 305 ( 3.7A)
None
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
 1.46A 5jj0B-3bo5A:
26.1		 5jj0B-3bo5A:
32.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR

(Homo sapiens) 		PF00856
(SET)
PF05033
(Pre-SET) 		6 TRP A 137
ASN A 209
HIS A 210
TYR A 248
PHE A 286
LYS A 271
 None
SAH  A 305 (-3.4A)
None
SAH  A 305 (-4.9A)
SAH  A 305 (-4.9A)
SAH  A 305 ( 4.1A)
 0.97A 5jj0B-3bo5A:
26.1		 5jj0B-3bo5A:
32.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1

(Mus musculus) 		PF00856
(SET)
PF01753
(zf-MYND) 		5 GLY A  18
ASN A 205
HIS A 206
TYR A 252
CYH A 274
 SFG  A 491 ( 4.2A)
SFG  A 491 (-3.3A)
None
SFG  A 491 (-4.8A)
ZN  A 497 (-2.2A)
 0.56A 5jj0B-3n71A:
5.7		 5jj0B-3n71A:
19.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC

(Homo sapiens) 		PF00856
(SET) 		6 GLY A 102
TRP A 103
ASN A 169
HIS A 170
TYR A 207
CYH A 219
 SAM  A 237 ( 3.7A)
None
SAM  A 237 (-3.3A)
SAM  A 237 (-4.7A)
None
ZN  A 232 ( 2.3A)
 0.32A 5jj0B-3ooiA:
19.2		 5jj0B-3ooiA:
30.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC

(Homo sapiens) 		PF00856
(SET) 		6 GLY A 102
TRP A 103
ASN A 169
HIS A 170
TYR A 207
CYH A 221
 SAM  A 237 ( 3.7A)
None
SAM  A 237 (-3.3A)
SAM  A 237 (-4.7A)
None
ZN  A 232 (-2.3A)
 1.28A 5jj0B-3ooiA:
19.2		 5jj0B-3ooiA:
30.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L

(Homo sapiens) 		PF00856
(SET) 		6 GLY A2151
TRP A2152
ASN A2217
HIS A2218
TYR A2255
CYH A2268
 SAM  A   7 (-3.4A)
None
SAM  A   7 (-3.9A)
None
None
ZN  A   1 ( 2.5A)
 0.44A 5jj0B-3opeA:
17.7		 5jj0B-3opeA:
29.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L

(Homo sapiens) 		PF00856
(SET) 		6 GLY A2151
TRP A2152
ASN A2217
HIS A2218
TYR A2255
CYH A2270
 SAM  A   7 (-3.4A)
None
SAM  A   7 (-3.9A)
None
None
ZN  A   1 (-2.7A)
 1.26A 5jj0B-3opeA:
17.7		 5jj0B-3opeA:
29.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqi GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]

(Coxiella
burnetii) 		PF00117
(GATase)
PF00958
(GMP_synt_C)
PF02540
(NAD_synthase) 		5 MET A  89
GLY A  88
PHE A 122
PHE A 180
GLN A 179
 None
 1.20A 5jj0B-3tqiA:
undetectable		 5jj0B-3tqiA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a7l MYOSIN IE HEAVY
CHAIN

(Dictyostelium
discoideum) 		PF00063
(Myosin_head) 		5 GLY C 389
ASN C 407
HIS C 507
TYR C 508
GLN C 400
 None
 1.43A 5jj0B-4a7lC:
undetectable		 5jj0B-4a7lC:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4au7 HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H2

(Mus musculus) 		PF00856
(SET) 		5 ASN A 182
HIS A 183
TYR A 217
PHE A 221
CYH A 229
 SAH  A1247 (-3.1A)
SAH  A1247 (-4.6A)
None
None
ZN  A1248 ( 2.3A)
 0.66A 5jj0B-4au7A:
8.0		 5jj0B-4au7A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fmu HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2

(Homo sapiens) 		PF00856
(SET) 		5 GLY A1561
TRP A1562
ASN A1628
HIS A1629
CYH A1678
 0UM  A1804 (-3.5A)
None
0UM  A1804 (-3.3A)
None
ZN  A1803 ( 2.2A)
 0.48A 5jj0B-4fmuA:
18.6		 5jj0B-4fmuA:
28.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fmu HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2

(Homo sapiens) 		PF00856
(SET) 		5 GLY A1561
TRP A1562
ASN A1628
HIS A1629
CYH A1680
 0UM  A1804 (-3.5A)
None
0UM  A1804 (-3.3A)
None
ZN  A1803 (-2.2A)
 1.49A 5jj0B-4fmuA:
18.6		 5jj0B-4fmuA:
28.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4mi5 HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2

(Homo sapiens) 		PF00856
(SET) 		5 GLY A 628
TRP A 629
ASN A 693
HIS A 694
TYR A 731
 None
 0.63A 5jj0B-4mi5A:
10.5		 5jj0B-4mi5A:
30.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4

(Arabidopsis
thaliana) 		PF00856
(SET)
PF02182
(SAD_SRA)
PF05033
(Pre-SET) 		6 GLY A 457
TRP A 458
ASN A 551
HIS A 552
TYR A 593
CYH A 612
 SAH  A 801 (-3.6A)
SAH  A 801 (-4.9A)
SAH  A 801 (-3.2A)
None
None
ZN  A 805 ( 2.4A)
 0.34A 5jj0B-4qeoA:
29.5		 5jj0B-4qeoA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4

(Arabidopsis
thaliana) 		PF00856
(SET)
PF02182
(SAD_SRA)
PF05033
(Pre-SET) 		5 GLY A 457
TRP A 458
HIS A 552
TYR A 593
CYH A 614
 SAH  A 801 (-3.6A)
SAH  A 801 (-4.9A)
None
None
ZN  A 805 ( 2.4A)
 1.43A 5jj0B-4qeoA:
29.5		 5jj0B-4qeoA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qpb LYSOSTAPHIN

(Staphylococcus
simulans) 		PF01551
(Peptidase_M23) 		5 GLY A 315
HIS A 323
PHE A 381
PHE A 363
GLN A 364
 None
 1.22A 5jj0B-4qpbA:
undetectable		 5jj0B-4qpbA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w2r ENHANCER OF ZESTE 2
POLYCOMB REPRESSIVE
COMPLEX 2 SUBUNIT

(Anolis
carolinensis) 		no annotation 5 GLY A 520
TRP A 521
ASN A 585
HIS A 586
TYR A 623
 CJD  A 708 (-3.6A)
None
CJD  A 708 (-3.5A)
None
None
 0.48A 5jj0B-4w2rA:
15.9		 5jj0B-4w2rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D

(Homo sapiens) 		PF00856
(SET) 		5 GLY A5408
ASN A5474
HIS A5475
TYR A5512
CYH A5525
 SAH  A5602 (-3.6A)
SAH  A5602 (-3.1A)
None
None
ZN  A5601 ( 2.2A)
 0.25A 5jj0B-4z4pA:
13.5		 5jj0B-4z4pA:
26.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C

(Homo sapiens) 		PF00856
(SET) 		5 GLY A4782
ASN A4848
HIS A4849
TYR A4886
CYH A4899
 SAH  A5002 (-3.5A)
SAH  A5002 (-2.7A)
SAH  A5002 (-4.6A)
None
ZN  A5001 ( 2.0A)
 0.31A 5jj0B-5f59A:
13.2		 5jj0B-5f59A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A

(Homo sapiens) 		PF00856
(SET) 		5 ASN A3906
HIS A3907
TYR A3944
PHE A3946
CYH A3957
 SAH  A4001 (-3.0A)
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
None
ZN  A4002 ( 2.3A)
 0.75A 5jj0B-5f6lA:
13.3		 5jj0B-5f6lA:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A

(Homo sapiens) 		PF00856
(SET) 		5 GLY A3840
ASN A3906
HIS A3907
TYR A3944
CYH A3957
 SAH  A4001 (-3.4A)
SAH  A4001 (-3.0A)
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
ZN  A4002 ( 2.3A)
 0.26A 5jj0B-5f6lA:
13.3		 5jj0B-5f6lA:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fbh EXTRACELLULAR
CALCIUM-SENSING
RECEPTOR

(Homo sapiens) 		no annotation 5 MET B 473
GLY B 474
SER B 426
ASN B 472
TYR B 421
 None
 1.41A 5jj0B-5fbhB:
undetectable		 5jj0B-5fbhB:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2

(Homo sapiens) 		PF00856
(SET)
PF01753
(zf-MYND) 		5 GLY A  18
ASN A 206
HIS A 207
TYR A 240
CYH A 262
 SAM  A 501 ( 4.1A)
SAM  A 501 (-3.2A)
None
6TM  A 502 ( 3.6A)
ZN  A 505 (-2.3A)
 0.61A 5jj0B-5kjmA:
6.0		 5jj0B-5kjmA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ls6 HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2,HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2,HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2

(Homo sapiens) 		PF00856
(SET)
PF11616
(EZH2_WD-Binding) 		5 GLY A 623
TRP A 624
ASN A 688
HIS A 689
TYR A 726
 74D  A 809 ( 3.9A)
None
74D  A 809 (-3.0A)
None
None
 0.74A 5jj0B-5ls6A:
14.6		 5jj0B-5ls6A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2

(Homo sapiens) 		PF00856
(SET) 		6 GLY A1074
TRP A1075
ASN A1141
HIS A1142
TYR A1179
CYH A1191
 SAM  A1304 ( 3.2A)
None
SAM  A1304 (-2.9A)
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 ( 2.3A)
 0.25A 5jj0B-5lsuA:
19.8		 5jj0B-5lsuA:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2

(Homo sapiens) 		PF00856
(SET) 		5 GLY A1074
TRP A1075
HIS A1142
TYR A1179
CYH A1193
 SAM  A1304 ( 3.2A)
None
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 (-2.3A)
 1.36A 5jj0B-5lsuA:
19.8		 5jj0B-5lsuA:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m22 HYDROQUINONE
DIOXYGENASE LARGE
SUBUNIT

(Sphingomonas
sp. TTNP3) 		no annotation 5 GLY B 259
SER B 282
ASN B  83
HIS B  86
GLN B 306
 None
 1.50A 5jj0B-5m22B:
undetectable		 5jj0B-5m22B:
19.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2

(Homo sapiens) 		PF00856
(SET)
PF05033
(Pre-SET) 		12 MET A1048
GLY A1049
TRP A1050
SER A1084
ASN A1112
HIS A1113
TYR A1154
PHE A1158
LYS A1162
PHE A1166
CYH A1168
GLN A1169
 SAM  A1505 (-3.4A)
SAM  A1505 ( 3.9A)
None
SAM  A1505 (-3.8A)
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
7L6  A1506 (-4.3A)
7L6  A1506 ( 4.6A)
SAM  A1505 (-4.3A)
ZN  A1504 (-2.2A)
None
 0.44A 5jj0B-5tuyA:
41.1		 5jj0B-5tuyA:
97.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ukh UNCHARACTERIZED
PROTEIN

(Streptococcus
intermedius) 		no annotation 5 MET A 479
SER A 406
TYR A 236
PHE A 402
GLN A 476
 None
 1.42A 5jj0B-5ukhA:
undetectable		 5jj0B-5ukhA:
20.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo sapiens) 		PF00856
(SET)
PF05033
(Pre-SET) 		11 MET A1136
GLY A1137
TRP A1138
SER A1172
ASN A1200
HIS A1201
TYR A1242
PHE A1246
LYS A1250
PHE A1254
CYH A1256
 SAM  A3001 (-3.4A)
SAM  A3001 (-3.6A)
None
SAM  A3001 (-3.7A)
SAM  A3001 (-3.4A)
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
9HJ  A3006 ( 4.3A)
9HJ  A3006 (-4.6A)
SAM  A3001 ( 4.5A)
ZN  A3005 ( 2.4A)
 0.61A 5jj0B-5vsdA:
39.9		 5jj0B-5vsdA:
77.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wfc HISTONE-LYSINE-N-MET
HYLTRANSFERASE EZH2,
POLYCOMB PROTEIN
SUZ12 CHIMERA

(Chaetomium
thermophilum) 		no annotation 5 GLY B 808
ASN B 880
HIS B 881
TYR B 918
PHE B 922
 A97  B8009 (-3.4A)
A97  B8009 (-3.9A)
None
None
None
 1.40A 5jj0B-5wfcB:
11.9		 5jj0B-5wfcB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wg6 HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2,POLYCOMB
PROTEIN SUZ12
(E.C.2.1.1.43)
CHIMERA

(Homo sapiens) 		no annotation 5 GLY A 623
TRP A 624
ASN A 688
HIS A 689
TYR A 726
 A9G  A9009 ( 4.2A)
None
A9G  A9009 (-3.1A)
None
None
 0.60A 5jj0B-5wg6A:
14.5		 5jj0B-5wg6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cen HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD3

(Homo sapiens) 		no annotation 6 GLY A1156
TRP A1157
ASN A1223
HIS A1224
TYR A1261
CYH A1273
 SAM  A1301 (-3.6A)
None
SAM  A1301 (-3.2A)
None
SAM  A1301 (-4.9A)
ZN  A1304 ( 2.3A)
 0.29A 5jj0B-6cenA:
19.7		 5jj0B-6cenA:
29.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cen HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD3

(Homo sapiens) 		no annotation 5 GLY A1156
TRP A1157
HIS A1224
TYR A1261
CYH A1275
 SAM  A1301 (-3.6A)
None
None
SAM  A1301 (-4.9A)
ZN  A1304 (-2.3A)
 1.46A 5jj0B-6cenA:
19.7		 5jj0B-6cenA:
29.58