SIMILAR PATTERNS OF AMINO ACIDS FOR 5JI0_D_BRLD501_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b0k PROTEIN (ACONITASE)

(Sus scrofa) 		PF00330
(Aconitase)
PF00694
(Aconitase_C) 		5 PHE A 544
GLN A 675
HIS A 646
LEU A 590
LEU A 541
 None
 1.29A 5ji0D-1b0kA:
undetectable		 5ji0D-1b0kA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k1d D-HYDANTOINASE

(Geobacillus
stearothermophilus) 		PF01979
(Amidohydro_1) 		5 GLY A 307
GLN A 310
LEU A 349
LEU A 375
TYR A 236
 None
 1.13A 5ji0D-1k1dA:
0.0		 5ji0D-1k1dA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcz BETA-METHYLASPARTASE

(Clostridium
tetanomorphum) 		PF05034
(MAAL_N)
PF07476
(MAAL_C) 		5 GLY A 174
HIS A 236
MET A 184
LEU A 384
TYR A 356
 None
 1.20A 5ji0D-1kczA:
undetectable		 5ji0D-1kczA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tkc TRANSKETOLASE

(Saccharomyces
cerevisiae) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 GLY A 158
CYH A 159
SER A 165
LEU A 243
TYR A 207
 M6T  A 681 (-3.5A)
None
None
None
None
 1.19A 5ji0D-1tkcA:
undetectable		 5ji0D-1tkcA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cfo GLUTAMYL-TRNA
SYNTHETASE

(Synechococcus
elongatus) 		PF00749
(tRNA-synt_1c) 		5 PHE A 136
TYR A 121
LEU A 105
HIS A 125
LEU A 128
 None
 1.37A 5ji0D-2cfoA:
0.0		 5ji0D-2cfoA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cya TYROSYL-TRNA
SYNTHETASE

(Aeropyrum
pernix) 		PF00579
(tRNA-synt_1b) 		5 GLY A  41
GLN A 169
TYR A 126
LEU A 120
MET A 176
 None
 1.36A 5ji0D-2cyaA:
0.4		 5ji0D-2cyaA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hpi DNA POLYMERASE III
ALPHA SUBUNIT

(Thermus
aquaticus) 		PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		5 PHE A 103
GLY A 105
GLN A 107
TYR A 604
LEU A  50
 None
 1.32A 5ji0D-2hpiA:
0.0		 5ji0D-2hpiA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iwb METHICILLIN
RESISTANCE MECR1
PROTEIN

(Staphylococcus
aureus) 		PF00905
(Transpeptidase) 		5 GLY A 568
GLN A 572
SER A 575
LEU A 517
TYR A 525
 GOL  A 604 (-3.5A)
None
None
None
None
 1.32A 5ji0D-2iwbA:
undetectable		 5ji0D-2iwbA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nlk PROTEIN TYROSINE
PHOSPHATASE,
RECEPTOR TYPE, G
VARIANT (FRAGMENT)

(Homo sapiens) 		PF00102
(Y_phosphatase) 		5 CYH A1316
GLN A1315
HIS A1350
LEU A1361
TYR A1262
 None
 0.97A 5ji0D-2nlkA:
0.0		 5ji0D-2nlkA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o0m TRANSCRIPTIONAL
REGULATOR, SORC
FAMILY

(Enterococcus
faecalis) 		PF04198
(Sugar-bind) 		5 PHE A 277
GLY A 244
LEU A 329
MET A 320
LEU A 294
 None
PO4  A 401 ( 4.2A)
None
None
None
 1.48A 5ji0D-2o0mA:
undetectable		 5ji0D-2o0mA:
20.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 CYH A 276
SER A 280
LEU A 321
MET A 355
HIS A 440
TYR A 464
 735  A 469 (-2.9A)
735  A 469 (-2.8A)
735  A 469 ( 4.3A)
735  A 469 (-2.9A)
735  A 469 (-4.0A)
735  A 469 (-4.6A)
 0.84A 5ji0D-2p54A:
37.5		 5ji0D-2p54A:
61.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 PHE A 273
CYH A 276
GLN A 277
SER A 280
LEU A 321
MET A 355
 735  A 469 (-3.7A)
735  A 469 (-2.9A)
735  A 469 (-4.4A)
735  A 469 (-2.8A)
735  A 469 ( 4.3A)
735  A 469 (-2.9A)
 1.05A 5ji0D-2p54A:
37.5		 5ji0D-2p54A:
61.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 PHE A 273
CYH A 276
SER A 280
LEU A 321
MET A 355
TYR A 464
 735  A 469 (-3.7A)
735  A 469 (-2.9A)
735  A 469 (-2.8A)
735  A 469 ( 4.3A)
735  A 469 (-2.9A)
735  A 469 (-4.6A)
 1.19A 5ji0D-2p54A:
37.5		 5ji0D-2p54A:
61.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rg4 UNCHARACTERIZED
PROTEIN

(Oceanicola
granulosus) 		PF13759
(2OG-FeII_Oxy_5) 		5 PHE A 203
SER A  79
LEU A  26
LEU A 180
TYR A  15
 None
 1.49A 5ji0D-2rg4A:
undetectable		 5ji0D-2rg4A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v3c SIGNAL RECOGNITION
54 KDA PROTEIN

(Methanocaldococcus
jannaschii) 		PF00448
(SRP54)
PF02881
(SRP54_N)
PF02978
(SRP_SPB) 		5 PHE C 289
GLY C  87
SER C 260
LEU C  38
LEU C 249
 None
 1.09A 5ji0D-2v3cC:
undetectable		 5ji0D-2v3cC:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vmj DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE

(Achromobacter
xylosoxidans) 		PF00394
(Cu-oxidase)
PF07732
(Cu-oxidase_3) 		5 GLY A 275
HIS A  22
LEU A 140
LEU A 148
TYR A 158
 None
 1.46A 5ji0D-2vmjA:
undetectable		 5ji0D-2vmjA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vqa SLL1358 PROTEIN

(Synechocystis
sp. PCC 6803) 		PF00190
(Cupin_1) 		5 PHE A 159
GLY A 151
HIS A 101
TYR A 208
LEU A 161
 None
None
MN  A1005 (-3.3A)
None
None
 1.36A 5ji0D-2vqaA:
undetectable		 5ji0D-2vqaA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x6k PHOSPHOTIDYLINOSITOL
3 KINASE 59F

(Drosophila
melanogaster) 		PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka) 		5 PHE A 860
CYH A 791
LEU A 811
MET A 845
LEU A 925
 None
 1.36A 5ji0D-2x6kA:
undetectable		 5ji0D-2x6kA:
16.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b0q PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		12 PHE A 282
GLY A 284
CYH A 285
GLN A 286
SER A 289
HIS A 323
TYR A 327
LEU A 330
MET A 364
HIS A 449
LEU A 453
TYR A 473
 MC5  A   1 (-4.4A)
MC5  A   1 ( 4.5A)
MC5  A   1 (-3.6A)
None
MC5  A   1 (-2.6A)
MC5  A   1 (-3.8A)
None
MC5  A   1 (-4.4A)
MC5  A   1 (-3.7A)
MC5  A   1 (-3.9A)
MC5  A   1 (-4.2A)
MC5  A   1 (-4.9A)
 0.58A 5ji0D-3b0qA:
40.5		 5ji0D-3b0qA:
98.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d5f PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 CYH A 285
HIS A 323
LEU A 330
HIS A 449
TYR A 473
 L41  A 501 (-3.5A)
L41  A 501 (-3.8A)
L41  A 501 (-4.9A)
L41  A 501 (-3.9A)
L41  A 501 (-4.8A)
 0.73A 5ji0D-3d5fA:
36.3		 5ji0D-3d5fA:
62.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwd ADP-RIBOSYLATION
FACTOR
GTPASE-ACTIVATING
PROTEIN 1

(Homo sapiens) 		PF01412
(ArfGap) 		5 GLY A  26
CYH A  22
HIS A  49
LEU A  99
TYR A 103
 None
ZN  A 501 (-2.3A)
None
None
None
 1.39A 5ji0D-3dwdA:
undetectable		 5ji0D-3dwdA:
20.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		5 CYH D 285
TYR D 327
LEU D 330
MET D 364
HIS D 449
 PLB  D 701 (-3.2A)
None
PLB  D 701 ( 4.1A)
PLB  D 701 ( 4.8A)
None
 0.97A 5ji0D-3dzuD:
38.1		 5ji0D-3dzuD:
89.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		5 GLY D 284
CYH D 285
LEU D 330
MET D 364
HIS D 449
 PLB  D 701 (-3.3A)
PLB  D 701 (-3.2A)
PLB  D 701 ( 4.1A)
PLB  D 701 ( 4.8A)
None
 1.11A 5ji0D-3dzuD:
38.1		 5ji0D-3dzuD:
89.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		6 GLY D 284
SER D 289
LEU D 330
MET D 364
HIS D 449
TYR D 473
 PLB  D 701 (-3.3A)
PLB  D 701 ( 3.9A)
PLB  D 701 ( 4.1A)
PLB  D 701 ( 4.8A)
None
None
 0.87A 5ji0D-3dzuD:
38.1		 5ji0D-3dzuD:
89.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		6 PHE D 282
GLY D 284
CYH D 285
GLN D 286
LEU D 330
MET D 364
 None
PLB  D 701 (-3.3A)
PLB  D 701 (-3.2A)
None
PLB  D 701 ( 4.1A)
PLB  D 701 ( 4.8A)
 1.08A 5ji0D-3dzuD:
38.1		 5ji0D-3dzuD:
89.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		7 PHE D 282
GLY D 284
GLN D 286
SER D 289
LEU D 330
MET D 364
TYR D 473
 None
PLB  D 701 (-3.3A)
None
PLB  D 701 ( 3.9A)
PLB  D 701 ( 4.1A)
PLB  D 701 ( 4.8A)
None
 1.00A 5ji0D-3dzuD:
38.1		 5ji0D-3dzuD:
89.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		5 TYR D 327
LEU D 330
MET D 364
HIS D 449
TYR D 473
 None
PLB  D 701 ( 4.1A)
PLB  D 701 ( 4.8A)
None
None
 0.97A 5ji0D-3dzuD:
38.1		 5ji0D-3dzuD:
89.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f41 PHYTASE

(Mitsuokella
multacida) 		PF14566
(PTPlike_phytase) 		5 PHE A 315
TYR A 248
LEU A 129
LEU A 267
TYR A 237
 None
None
None
None
EDO  A   8 (-4.3A)
 1.49A 5ji0D-3f41A:
undetectable		 5ji0D-3f41A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o21 GLUTAMATE RECEPTOR 3

(Rattus
norvegicus) 		PF01094
(ANF_receptor) 		5 PHE A 242
HIS A 216
LEU A 229
LEU A 124
TYR A 128
 None
NAG  A 391 ( 4.8A)
None
None
None
 1.48A 5ji0D-3o21A:
undetectable		 5ji0D-3o21A:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o47 ADP-RIBOSYLATION
FACTOR
GTPASE-ACTIVATING
PROTEIN 1,
ADP-RIBOSYLATION
FACTOR 1

(Homo sapiens) 		PF00025
(Arf)
PF01412
(ArfGap) 		5 GLY A  26
CYH A  22
HIS A  49
LEU A  99
TYR A 103
 None
ZN  A 501 (-2.3A)
None
None
None
 1.49A 5ji0D-3o47A:
undetectable		 5ji0D-3o47A:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qc0 SUGAR ISOMERASE

(Sinorhizobium
meliloti) 		PF01261
(AP_endonuc_2) 		5 GLY A 219
HIS A 144
TYR A 147
LEU A 215
HIS A 179
 None
None
UNL  A 300 ( 4.2A)
UNL  A 300 ( 4.5A)
UNL  A 300 ( 4.1A)
 1.33A 5ji0D-3qc0A:
undetectable		 5ji0D-3qc0A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3umc HALOACID
DEHALOGENASE

(Pseudomonas
aeruginosa) 		PF13419
(HAD_2) 		5 PHE A   9
GLY A  10
HIS A  68
LEU A  64
TYR A  47
 CL  A 234 (-4.4A)
None
None
None
None
 1.37A 5ji0D-3umcA:
undetectable		 5ji0D-3umcA:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n2x DL-2-HALOACID
DEHALOGENASE

(Methylobacterium
sp. CPA1) 		PF10778
(DehI) 		5 GLN A  12
HIS A  16
LEU A  22
HIS A  15
LEU A 165
 None
None
None
GOL  A 401 (-4.6A)
None
 1.34A 5ji0D-4n2xA:
undetectable		 5ji0D-4n2xA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n6b SERINE
ACETYLTRANSFERASE
APOENZYME

(Glycine max) 		PF00132
(Hexapep)
PF06426
(SATase_N) 		5 SER A 110
TYR A  41
LEU A  38
HIS A  59
LEU A 120
 None
 1.44A 5ji0D-4n6bA:
undetectable		 5ji0D-4n6bA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nnd TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 18

(Homo sapiens) 		PF00102
(Y_phosphatase) 		5 GLN A 191
HIS A 228
LEU A 239
MET A 210
TYR A 144
 None
 1.22A 5ji0D-4nndA:
undetectable		 5ji0D-4nndA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oya ADENYLATE CYCLASE
TYPE 10

(Homo sapiens) 		PF00211
(Guanylate_cyc) 		5 GLY A 330
GLN A 331
HIS A 164
TYR A 318
HIS A 162
 None
GOL  A 502 (-3.7A)
None
None
GOL  A 502 (-4.1A)
 1.16A 5ji0D-4oyaA:
undetectable		 5ji0D-4oyaA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s1n PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE

(Streptococcus
pneumoniae) 		PF00551
(Formyl_trans_N) 		5 PHE A   7
GLY A  81
LEU A  37
LEU A  65
TYR A  61
 None
CL  A 202 ( 4.8A)
None
None
None
 1.22A 5ji0D-4s1nA:
undetectable		 5ji0D-4s1nA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uuo CYTOSOLIC MALATE
DEHYDROGENASE

(Trichomonas
vaginalis) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 PHE A  83
GLY A  16
LEU A 156
MET A 153
LEU A  28
 None
 1.36A 5ji0D-4uuoA:
undetectable		 5ji0D-4uuoA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5do7 ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
5

(Homo sapiens) 		PF00005
(ABC_tran)
PF01061
(ABC2_membrane) 		5 PHE A 515
GLY A 513
TYR A 628
LEU A 627
LEU A 472
 None
 1.37A 5ji0D-5do7A:
undetectable		 5ji0D-5do7A:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gnx BETA-GLUCOSIDASE

(metagenome) 		PF00232
(Glyco_hydro_1) 		5 PHE A  15
GLY A  14
LEU A 121
MET A 354
TYR A 442
 None
 1.21A 5ji0D-5gnxA:
undetectable		 5ji0D-5gnxA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i51 TRANSKETOLASE

(Scheffersomyces
stipitis) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 GLY A 156
CYH A 157
SER A 163
LEU A 241
TYR A 205
 TPP  A 701 (-3.5A)
None
None
None
None
 1.22A 5ji0D-5i51A:
undetectable		 5ji0D-5i51A:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM

(Homo sapiens) 		PF00343
(Phosphorylase) 		5 GLN A 295
HIS A 341
LEU A  85
LEU A 279
TYR A 280
 None
 1.35A 5ji0D-5ikpA:
undetectable		 5ji0D-5ikpA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k1g 1-CYS PEROXIREDOXIN

(Vibrio
vulnificus) 		PF08534
(Redoxin) 		5 PHE A  30
GLY A 132
TYR A 125
LEU A 137
LEU A  13
 None
 1.37A 5ji0D-5k1gA:
undetectable		 5ji0D-5k1gA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l9w ACETOPHENONE
CARBOXYLASE DELTA
SUBUNIT

(Aromatoleum
aromaticum) 		PF02538
(Hydantoinase_B) 		5 PHE A 436
GLY A 478
GLN A 424
HIS A 372
TYR A 324
 None
 1.01A 5ji0D-5l9wA:
1.6		 5ji0D-5l9wA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lrb ALPHA-1,4 GLUCAN
PHOSPHORYLASE

(Hordeum vulgare) 		PF00343
(Phosphorylase) 		5 GLN A 344
HIS A 385
LEU A 132
LEU A 328
TYR A 329
 None
 1.48A 5ji0D-5lrbA:
undetectable		 5ji0D-5lrbA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nd5 TRANSKETOLASE

(Chlamydomonas
reinhardtii) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 GLY A 209
CYH A 210
SER A 216
LEU A 294
TYR A 258
 TPP  A 801 (-3.5A)
None
None
None
None
 1.23A 5ji0D-5nd5A:
undetectable		 5ji0D-5nd5A:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ojr -

(-) 		no annotation 5 PHE A 232
GLY A 236
SER A 255
HIS A 219
TYR A 206
 None
 1.45A 5ji0D-5ojrA:
undetectable		 5ji0D-5ojrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vkq NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L

(Drosophila
melanogaster) 		PF00023
(Ank)
PF00520
(Ion_trans)
PF12796
(Ank_2)
PF13637
(Ank_4) 		5 GLY A1067
HIS A1049
LEU A1014
MET A1059
LEU A1096
 None
 1.31A 5ji0D-5vkqA:
undetectable		 5ji0D-5vkqA:
9.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3t E3 UBIQUITIN-PROTEIN
LIGASE RNF31

(Mus musculus) 		no annotation 5 PHE B 503
GLY B 557
GLN B 507
SER B 509
LEU B 518
 None
 1.39A 5ji0D-5y3tB:
undetectable		 5ji0D-5y3tB:
14.34