SIMILAR PATTERNS OF AMINO ACIDS FOR 5JI0_A_9CRA501_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b0k PROTEIN (ACONITASE)

(Sus scrofa) 		PF00330
(Aconitase)
PF00694
(Aconitase_C) 		5 ILE A  42
TRP A 195
LEU A  21
VAL A 269
CYH A 178
 None
 1.18A 5ji0A-1b0kA:
undetectable		 5ji0A-1b0kA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b4p PROTEIN (GLUTATHIONE
S-TRANSFERASE)

(Rattus
norvegicus) 		PF00043
(GST_C)
PF02798
(GST_N) 		5 ILE A  16
LEU A 158
LEU A  79
ALA A  80
LEU A  12
 None
None
None
None
GPS  A 218 (-4.3A)
 1.24A 5ji0A-1b4pA:
undetectable		 5ji0A-1b4pA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c3e GLYCINAMIDE
RIBONUCLEOTIDE
TRANSFORMYLASE

(Escherichia
coli) 		PF00551
(Formyl_trans_N) 		5 ILE A 181
LEU A 150
ALA A 175
VAL A  82
LEU A 189
 None
 1.17A 5ji0A-1c3eA:
undetectable		 5ji0A-1c3eA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dlc DELTA-ENDOTOXIN
CRYIIIA

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		5 ILE A 622
GLN A 586
PHE A 575
LEU A 577
CYH A 540
 None
 1.23A 5ji0A-1dlcA:
undetectable		 5ji0A-1dlcA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e19 CARBAMATE KINASE

(Pyrococcus
furiosus) 		PF00696
(AA_kinase) 		5 ILE A  37
LEU A  97
ALA A  96
VAL A   5
LEU A 234
 None
 0.92A 5ji0A-1e19A:
undetectable		 5ji0A-1e19A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1elj MALTODEXTRIN-BINDING
PROTEIN

(Pyrococcus
furiosus) 		PF13416
(SBP_bac_8) 		5 GLN A  23
LEU A  19
PHE A  22
LEU A  25
ALA A  26
 None
 1.08A 5ji0A-1eljA:
undetectable		 5ji0A-1eljA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ffv CUTL, MOLYBDOPROTEIN
OF CARBON MONOXIDE
DEHYDROGENASE

(Hydrogenophaga
pseudoflava) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		5 ILE B 117
GLN B 113
LEU B 103
ALA B 104
VAL B 292
 None
 1.19A 5ji0A-1ffvB:
undetectable		 5ji0A-1ffvB:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gvf TAGATOSE-BISPHOSPHAT
E ALDOLASE AGAY

(Escherichia
coli) 		PF01116
(F_bP_aldolase) 		5 ILE A 176
GLN A 192
PHE A 191
LEU A 194
ALA A 195
 None
 1.17A 5ji0A-1gvfA:
undetectable		 5ji0A-1gvfA:
21.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hg4 ULTRASPIRACLE

(Drosophila
melanogaster) 		PF00104
(Hormone_recep) 		5 TRP A 318
LEU A 322
VAL A 382
CYH A 472
LEU A 476
 None
LPP  A   1 ( 4.8A)
LPP  A   1 (-4.8A)
LPP  A   1 ( 4.2A)
LPP  A   1 (-4.2A)
 0.51A 5ji0A-1hg4A:
24.3		 5ji0A-1hg4A:
44.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hg4 ULTRASPIRACLE

(Drosophila
melanogaster) 		PF00104
(Hormone_recep) 		5 TRP A 318
LEU A 366
VAL A 382
CYH A 472
LEU A 476
 None
LPP  A   1 ( 4.4A)
LPP  A   1 (-4.8A)
LPP  A   1 ( 4.2A)
LPP  A   1 (-4.2A)
 0.74A 5ji0A-1hg4A:
24.3		 5ji0A-1hg4A:
44.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jmv UNIVERSAL STRESS
PROTEIN A

(Haemophilus
influenzae) 		PF00582
(Usp) 		5 ILE A  35
LEU A 106
ALA A  97
VAL A  76
LEU A  18
 None
 1.17A 5ji0A-1jmvA:
undetectable		 5ji0A-1jmvA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l1e MYCOLIC ACID
SYNTHASE

(Mycobacterium
tuberculosis) 		PF02353
(CMAS) 		5 ILE A 169
TRP A 239
PHE A 200
ALA A 138
CYH A 269
 CO3  A 903 (-4.8A)
None
None
SAH  A 900 (-3.4A)
None
 1.23A 5ji0A-1l1eA:
undetectable		 5ji0A-1l1eA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lfw PEPV

(Lactobacillus
delbrueckii) 		PF01546
(Peptidase_M20) 		5 ILE A 261
PHE A 286
LEU A 283
ALA A 284
LEU A 232
 None
 1.21A 5ji0A-1lfwA:
undetectable		 5ji0A-1lfwA:
18.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pcg ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 TRP A 383
LEU A 387
ARG A 394
VAL A 418
LEU A 525
 None
EST  A   1 (-4.0A)
EST  A   1 (-3.7A)
None
EST  A   1 (-3.6A)
 0.96A 5ji0A-1pcgA:
25.1		 5ji0A-1pcgA:
32.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1r20 ULTRASPIRACLE
PROTEIN

(Heliothis
virescens) 		PF00104
(Hormone_recep) 		5 GLN A 256
TRP A 286
LEU A 290
ARG A 297
LEU A 435
 None
None
EPH  A4000 ( 4.8A)
None
EPH  A4000 ( 4.6A)
 1.20A 5ji0A-1r20A:
24.0		 5ji0A-1r20A:
45.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1r20 ULTRASPIRACLE
PROTEIN

(Heliothis
virescens) 		PF00104
(Hormone_recep) 		6 TRP A 286
LEU A 290
ARG A 297
LEU A 325
VAL A 341
LEU A 435
 None
EPH  A4000 ( 4.8A)
None
None
EPH  A4000 (-4.9A)
EPH  A4000 ( 4.6A)
 0.84A 5ji0A-1r20A:
24.0		 5ji0A-1r20A:
45.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1uhl RETINOIC ACID
RECEPTOR RXR-BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 GLN A 346
TRP A 376
LEU A 380
ALA A 398
LEU A 526
 None
None
MEI  A1001 (-3.8A)
MEI  A1001 (-3.4A)
None
 1.15A 5ji0A-1uhlA:
34.0		 5ji0A-1uhlA:
87.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1uhl RETINOIC ACID
RECEPTOR RXR-BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		11 ILE A 339
GLN A 346
TRP A 376
LEU A 380
PHE A 384
ARG A 387
LEU A 397
ALA A 398
VAL A 413
CYH A 503
LEU A 507
 MEI  A1001 (-3.8A)
None
None
MEI  A1001 (-3.8A)
MEI  A1001 (-4.5A)
MEI  A1001 (-3.6A)
MEI  A1001 ( 4.4A)
MEI  A1001 (-3.4A)
MEI  A1001 (-4.1A)
MEI  A1001 (-4.0A)
MEI  A1001 (-4.6A)
 0.56A 5ji0A-1uhlA:
34.0		 5ji0A-1uhlA:
87.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x40 ARAP2

(Homo sapiens) 		PF00536
(SAM_1) 		5 ILE A  18
GLN A  29
LEU A  27
LEU A  31
LEU A  71
 None
 1.22A 5ji0A-1x40A:
undetectable		 5ji0A-1x40A:
17.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xiu RXR-LIKE PROTEIN

(Biomphalaria
glabrata) 		PF00104
(Hormone_recep) 		11 ILE A 242
GLN A 249
TRP A 279
LEU A 283
PHE A 287
ARG A 290
LEU A 300
ALA A 301
VAL A 316
CYH A 406
LEU A 410
 9CR  A 201 ( 4.4A)
9CR  A 201 (-4.1A)
None
9CR  A 201 ( 4.1A)
9CR  A 201 (-4.7A)
9CR  A 201 (-2.8A)
9CR  A 201 (-4.4A)
9CR  A 201 (-3.4A)
9CR  A 201 (-4.2A)
9CR  A 201 (-3.6A)
9CR  A 201 ( 4.8A)
 0.32A 5ji0A-1xiuA:
32.7		 5ji0A-1xiuA:
79.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xls RETINOIC ACID
RECEPTOR RXR-ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		11 ILE A 268
GLN A 275
TRP A 305
LEU A 309
PHE A 313
ARG A 316
LEU A 326
ALA A 327
VAL A 342
CYH A 432
LEU A 436
 9CR  A 801 (-3.9A)
9CR  A 801 (-4.7A)
None
9CR  A 801 (-4.2A)
9CR  A 801 (-4.3A)
9CR  A 801 (-2.6A)
9CR  A 801 (-4.1A)
9CR  A 801 (-3.3A)
9CR  A 801 ( 4.3A)
9CR  A 801 ( 3.7A)
9CR  A 801 (-4.7A)
 0.34A 5ji0A-1xlsA:
34.7		 5ji0A-1xlsA:
99.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xr6 GENOME POLYPROTEIN

(Rhinovirus A) 		PF00680
(RdRP_1) 		5 ILE A 299
GLN A 248
PHE A 247
LEU A 250
LEU A 351
 None
 1.22A 5ji0A-1xr6A:
undetectable		 5ji0A-1xr6A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z6r MLC PROTEIN

(Escherichia
coli) 		PF00480
(ROK) 		6 ILE A 128
GLN A 114
LEU A  99
LEU A 116
VAL A 164
LEU A 182
 None
 1.31A 5ji0A-1z6rA:
undetectable		 5ji0A-1z6rA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cgj L-RHAMNULOSE KINASE

(Escherichia
coli) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		5 ILE A 371
LEU A 408
LEU A 375
ALA A 376
VAL A 306
 None
 1.25A 5ji0A-2cgjA:
undetectable		 5ji0A-2cgjA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gjm LACTOPEROXIDASE

(Bubalus bubalis) 		PF03098
(An_peroxidase) 		6 ILE A 478
LEU A 467
ARG A 426
LEU A 422
ALA A  61
LEU A 460
 None
 1.26A 5ji0A-2gjmA:
undetectable		 5ji0A-2gjmA:
17.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2gl8 RETINOIC ACID
RECEPTOR RXR-GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		8 TRP A  84
LEU A  88
PHE A  92
ARG A  95
LEU A 105
ALA A 106
VAL A 121
CYH A 211
 None
 0.71A 5ji0A-2gl8A:
27.6		 5ji0A-2gl8A:
84.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gp4 6-PHOSPHOGLUCONATE
DEHYDRATASE

(Shewanella
oneidensis) 		PF00920
(ILVD_EDD) 		5 ILE A 291
LEU A 366
LEU A 295
ALA A 296
VAL A 318
 None
 1.00A 5ji0A-2gp4A:
undetectable		 5ji0A-2gp4A:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hxo PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor) 		PF00440
(TetR_N)
PF02909
(TetR_C) 		5 PHE A 217
LEU A 218
ALA A 219
VAL A  75
LEU A 131
 None
 1.08A 5ji0A-2hxoA:
undetectable		 5ji0A-2hxoA:
25.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2nxx ULTRASPIRACLE (USP,
NR2B4)

(Tribolium
castaneum) 		PF00104
(Hormone_recep) 		6 LEU A 255
PHE A 259
ARG A 262
LEU A 272
ALA A 273
CYH A 378
 None
 0.90A 5ji0A-2nxxA:
24.8		 5ji0A-2nxxA:
63.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ocf ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 TRP A 383
LEU A 387
ARG A 394
VAL A 418
LEU A 525
 None
EST  A 596 ( 4.2A)
EST  A 596 (-4.0A)
CME  A 417 ( 3.2A)
EST  A 596 (-3.6A)
 0.99A 5ji0A-2ocfA:
24.9		 5ji0A-2ocfA:
29.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oda HYPOTHETICAL PROTEIN
PSPTO_2114

(Pseudomonas
syringae group
genomosp. 3) 		no annotation 5 ILE A 111
LEU A 126
LEU A   9
ALA A   8
LEU A 118
 None
 1.04A 5ji0A-2odaA:
undetectable		 5ji0A-2odaA:
23.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q60 RETINOID X RECEPTOR

(Polyandrocarpa
misakiensis) 		PF00104
(Hormone_recep) 		7 TRP A 180
LEU A 184
PHE A 188
ARG A 191
ALA A 202
VAL A 217
CYH A 307
 None
 0.51A 5ji0A-2q60A:
27.1		 5ji0A-2q60A:
71.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qe6 UNCHARACTERIZED
PROTEIN TFU_2867

(Thermobifida
fusca) 		PF04672
(Methyltransf_19) 		5 ILE A 160
PHE A 154
LEU A 185
ALA A 186
VAL A 136
 None
None
None
None
SAM  A 400 (-3.8A)
 1.19A 5ji0A-2qe6A:
undetectable		 5ji0A-2qe6A:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wnr PROBABLE EXOSOME
COMPLEX EXONUCLEASE
2

(Methanothermobacter
thermautotrophicus) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		5 ILE A 115
LEU A 194
LEU A 162
ALA A 160
CYH A 232
 None
 1.17A 5ji0A-2wnrA:
undetectable		 5ji0A-2wnrA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ymz GALECTIN 2

(Gallus gallus) 		PF00337
(Gal-bind_lectin) 		5 ILE A  33
TRP A  65
LEU A  42
LEU A 117
CYH A  57
 None
 1.11A 5ji0A-2ymzA:
undetectable		 5ji0A-2ymzA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z1b DELTA-AMINOLEVULINIC
ACID DEHYDRATASE

(Mus musculus) 		PF00490
(ALAD) 		5 LEU A 235
LEU A 226
ALA A 230
VAL A 175
LEU A 249
 None
 1.22A 5ji0A-2z1bA:
undetectable		 5ji0A-2z1bA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z1p COLLAGEN ADHESIN
PROTEIN

(Enterococcus
faecalis) 		PF05737
(Collagen_bind) 		5 ILE A 252
GLN A 246
PHE A 244
LEU A 241
ALA A 242
 None
 1.12A 5ji0A-2z1pA:
undetectable		 5ji0A-2z1pA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqc COMPONENT A OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE

(Micrococcus
luteus) 		PF00348
(polyprenyl_synt)
no annotation 		5 ILE B 123
GLN A  89
LEU A  93
PHE A  92
VAL B  76
 None
None
None
None
2DE  B 329 ( 4.5A)
 1.24A 5ji0A-3aqcB:
undetectable		 5ji0A-3aqcB:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b5q PUTATIVE SULFATASE
YIDJ

(Bacteroides
thetaiotaomicron) 		PF00884
(Sulfatase)
PF16347
(DUF4976) 		5 PHE A 311
LEU A 355
ALA A 356
VAL A 307
LEU A  71
 None
EDO  A 503 (-4.4A)
None
None
None
 1.24A 5ji0A-3b5qA:
undetectable		 5ji0A-3b5qA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dj4 BIFUNCTIONAL PROTEIN
GLMU

(Mycobacterium
tuberculosis) 		PF00132
(Hexapep)
PF12804
(NTP_transf_3) 		5 ILE A  44
LEU A 123
ALA A 124
VAL A  54
LEU A  74
 None
 1.13A 5ji0A-3dj4A:
undetectable		 5ji0A-3dj4A:
19.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dzu RETINOIC ACID
RECEPTOR RXR-ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		11 ILE A 268
GLN A 275
TRP A 305
LEU A 309
PHE A 313
ARG A 316
LEU A 326
ALA A 327
VAL A 342
CYH A 432
LEU A 436
 9CR  A7223 (-3.9A)
9CR  A7223 (-4.6A)
None
9CR  A7223 ( 4.4A)
9CR  A7223 (-4.5A)
9CR  A7223 (-3.7A)
9CR  A7223 (-3.8A)
9CR  A7223 ( 4.7A)
9CR  A7223 ( 4.5A)
9CR  A7223 (-3.8A)
9CR  A7223 ( 4.7A)
 0.62A 5ji0A-3dzuA:
33.8		 5ji0A-3dzuA:
59.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e1k GALACTOSE/LACTOSE
METABOLISM
REGULATORY PROTEIN
GAL80

(Kluyveromyces
lactis) 		PF01408
(GFO_IDH_MocA) 		5 ILE A 106
GLN A  83
PHE A  81
LEU A  78
VAL A 121
 None
 1.09A 5ji0A-3e1kA:
undetectable		 5ji0A-3e1kA:
19.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3eyb NUCLEAR HORMONE
RECEPTOR RXR

(Branchiostoma
floridae) 		PF00104
(Hormone_recep) 		5 LEU A 338
PHE A 342
ALA A 356
VAL A 371
CYH A 461
 None
 0.81A 5ji0A-3eybA:
28.4		 5ji0A-3eybA:
83.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3eyb NUCLEAR HORMONE
RECEPTOR RXR

(Branchiostoma
floridae) 		PF00104
(Hormone_recep) 		5 PHE A 342
LEU A 355
ALA A 356
VAL A 371
CYH A 461
 None
 1.03A 5ji0A-3eybA:
28.4		 5ji0A-3eybA:
83.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h3z CYCLIC
NUCLEOTIDE-BINDING
PROTEIN

(Ruegeria
pomeroyi) 		PF00027
(cNMP_binding)
PF13545
(HTH_Crp_2) 		5 ILE A 181
LEU A 192
ALA A 195
VAL A  76
LEU A 162
 None
 1.13A 5ji0A-3h3zA:
undetectable		 5ji0A-3h3zA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jac PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT 1

(Mus musculus) 		PF12166
(Piezo_RRas_bdg) 		5 ILE A2403
LEU A2232
LEU A2357
ALA A2355
LEU A2371
 None
 1.23A 5ji0A-3jacA:
undetectable		 5ji0A-3jacA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l0g NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE

(Ehrlichia
chaffeensis) 		PF01729
(QRPTase_C)
PF02749
(QRPTase_N) 		5 ILE A  94
LEU A  13
ALA A  12
VAL A  63
LEU A 271
 None
 1.01A 5ji0A-3l0gA:
undetectable		 5ji0A-3l0gA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l6a EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4
GAMMA 2

(Homo sapiens) 		PF02020
(W2)
PF02847
(MA3) 		5 GLN A 143
LEU A 139
LEU A 144
VAL A 162
LEU A 128
 None
None
None
MES  A 361 (-3.6A)
None
 1.23A 5ji0A-3l6aA:
undetectable		 5ji0A-3l6aA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1c ENVELOPE
GLYCOPROTEIN H

(Human
alphaherpesvirus
2) 		PF02489
(Herpes_glycop_H)
PF17488
(Herpes_glycoH_C) 		5 GLN A 475
LEU A 476
LEU A 412
ALA A 413
LEU A 209
 None
 1.20A 5ji0A-3m1cA:
undetectable		 5ji0A-3m1cA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mw3 NEUREXIN-2-BETA

(Rattus
norvegicus) 		PF02210
(Laminin_G_2) 		5 ILE A 247
TRP A 102
LEU A 268
LEU A 271
ALA A 272
 None
 1.07A 5ji0A-3mw3A:
undetectable		 5ji0A-3mw3A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyw PUTATIVE
OXIDOREDUCTASE

(Bacteroides
thetaiotaomicron) 		PF00106
(adh_short) 		5 ILE A  21
LEU A  34
LEU A  25
ALA A  26
VAL A 141
 None
 0.99A 5ji0A-3nywA:
undetectable		 5ji0A-3nywA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o7j OHCU DECARBOXYLASE

(Klebsiella
pneumoniae) 		PF09349
(OHCU_decarbox) 		5 GLN A   6
LEU A  10
PHE A   7
LEU A   4
ALA A   3
 None
 1.16A 5ji0A-3o7jA:
undetectable		 5ji0A-3o7jA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o80 HEXOKINASE

(Kluyveromyces
lactis) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		5 ILE A 130
GLN A 125
PHE A 129
LEU A 126
VAL A  94
 None
 1.18A 5ji0A-3o80A:
undetectable		 5ji0A-3o80A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3poy NEUREXIN-1-ALPHA

(Bos taurus) 		PF00008
(EGF)
PF02210
(Laminin_G_2) 		5 ILE A 965
GLN A 955
PHE A 956
LEU A1076
ALA A1077
 None
 1.19A 5ji0A-3poyA:
undetectable		 5ji0A-3poyA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qmj ENOYL-COA HYDRATASE,
ECHA8_6

(Mycobacterium
marinum) 		PF00378
(ECH_1) 		5 ILE A 112
LEU A 145
LEU A  90
ALA A  91
VAL A 101
 None
 1.15A 5ji0A-3qmjA:
undetectable		 5ji0A-3qmjA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ru6 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE

(Campylobacter
jejuni) 		PF00215
(OMPdecase) 		5 ILE A 222
ARG A 196
LEU A 192
VAL A   5
LEU A  25
 None
 1.24A 5ji0A-3ru6A:
undetectable		 5ji0A-3ru6A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t34 DYNAMIN-RELATED
PROTEIN 1A, LINKER,
DYNAMIN-RELATED
PROTEIN 1A

(Arabidopsis
thaliana) 		PF00350
(Dynamin_N)
PF01031
(Dynamin_M) 		5 ILE A 176
LEU A 283
PHE A 207
ALA A 179
VAL A 294
 None
 1.23A 5ji0A-3t34A:
undetectable		 5ji0A-3t34A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v4y SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PP1-ALPHA CATALYTIC
SUBUNIT

(Homo sapiens) 		PF00149
(Metallophos)
PF16891
(STPPase_N) 		5 ILE A 104
LEU A  30
LEU A 108
ALA A 109
CYH A 140
 None
 1.16A 5ji0A-3v4yA:
undetectable		 5ji0A-3v4yA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ags THIOL-DEPENDENT
REDUCTASE 1

(Leishmania
infantum) 		PF13417
(GST_N_3)
PF16865
(GST_C_5) 		5 GLN A 105
LEU A 139
LEU A 103
ALA A 104
LEU A 191
 None
 1.01A 5ji0A-4agsA:
undetectable		 5ji0A-4agsA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4am3 POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE

(Caulobacter
vibrioides) 		PF00013
(KH_1)
PF01138
(RNase_PH)
PF03725
(RNase_PH_C)
PF03726
(PNPase) 		5 ILE A 219
GLN A 213
ALA A 183
VAL A  31
LEU A  16
 None
 1.14A 5ji0A-4am3A:
undetectable		 5ji0A-4am3A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ch7 NIRD-LIKE PROTEIN

(Hydrogenobacter
thermophilus) 		no annotation 5 ILE A 175
LEU A 205
LEU A 197
ALA A 194
LEU A 217
 None
 0.94A 5ji0A-4ch7A:
undetectable		 5ji0A-4ch7A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gzi GLUCAN
ENDO-1,3-BETA-D-GLUC
OSIDASE

(Solanum
tuberosum) 		PF00332
(Glyco_hydro_17) 		5 ILE A 185
LEU A 248
LEU A 189
ALA A 190
VAL A 119
 None
 1.13A 5ji0A-4gziA:
undetectable		 5ji0A-4gziA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hhr ALPHA-DIOXYGENASE

(Arabidopsis
thaliana) 		PF03098
(An_peroxidase) 		5 ILE A 558
ARG A 566
ALA A 563
VAL A 492
LEU A 540
 None
CL  A 711 (-3.3A)
CL  A 711 ( 4.0A)
None
None
 1.13A 5ji0A-4hhrA:
undetectable		 5ji0A-4hhrA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iin 3-KETOACYL-ACYL
CARRIER PROTEIN
REDUCTASE (FABG)

(Helicobacter
pylori) 		PF13561
(adh_short_C2) 		5 ILE A  21
LEU A  46
LEU A  25
ALA A  26
VAL A 140
 None
None
None
None
NAD  A 301 (-4.7A)
 1.12A 5ji0A-4iinA:
undetectable		 5ji0A-4iinA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ip4 MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME-LIKE PROTEIN

(Ruegeria sp.
TM1040) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ILE A 311
GLN A 320
LEU A 316
ALA A 296
VAL A 154
 None
 1.19A 5ji0A-4ip4A:
undetectable		 5ji0A-4ip4A:
21.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4j5x RETINOIC ACID
RECEPTOR RXR-ALPHA,
NUCLEAR RECEPTOR
COACTIVATOR 1

(Homo sapiens) 		no annotation 11 ILE D 268
GLN D 275
TRP D 305
LEU D 309
PHE D 313
ARG D 316
LEU D 326
ALA D 327
VAL D 342
CYH D 432
LEU D 436
 None
 0.52A 5ji0A-4j5xD:
32.4		 5ji0A-4j5xD:
99.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ks8 SERINE/THREONINE-PRO
TEIN KINASE PAK 6

(Homo sapiens) 		PF00069
(Pkinase) 		5 ILE A 503
GLN A 660
LEU A 631
VAL A 493
LEU A 667
 None
 0.99A 5ji0A-4ks8A:
undetectable		 5ji0A-4ks8A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC

([Bacillus]
selenitireducens) 		PF03632
(Glyco_hydro_65m)
PF03633
(Glyco_hydro_65C)
PF03636
(Glyco_hydro_65N) 		5 ILE A 448
LEU A 452
ALA A 453
VAL A 424
LEU A 362
 None
 1.21A 5ji0A-4ktpA:
undetectable		 5ji0A-4ktpA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kvl FATTY ACID
ALPHA-OXIDASE

(Oryza sativa) 		PF03098
(An_peroxidase) 		5 ILE A 551
ARG A 559
ALA A 556
VAL A 485
LEU A 533
 None
PLM  A 702 (-2.9A)
PLM  A 702 (-3.4A)
None
None
 1.08A 5ji0A-4kvlA:
undetectable		 5ji0A-4kvlA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mca GLYCEROL
DEHYDROGENASE

(Serratia
plymuthica) 		PF00465
(Fe-ADH) 		5 ILE A 117
LEU A 164
ALA A 167
VAL A  40
LEU A  97
 None
 1.18A 5ji0A-4mcaA:
undetectable		 5ji0A-4mcaA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rax PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT 1

(Mus musculus) 		PF12166
(Piezo_RRas_bdg) 		5 ILE A2403
LEU A2232
LEU A2357
ALA A2355
LEU A2371
 None
 1.23A 5ji0A-4raxA:
undetectable		 5ji0A-4raxA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tx2 NON-RIBOSOMAL
PEPTIDE SYNTHETASE

(Actinoplanes
teichomyceticus) 		PF00668
(Condensation) 		5 LEU B 397
LEU B 437
ALA B 434
VAL B 325
LEU B 280
 None
 1.21A 5ji0A-4tx2B:
undetectable		 5ji0A-4tx2B:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v1u LYND

(Lyngbya
aestuarii) 		PF02624
(YcaO) 		5 ILE A 264
GLN A 258
LEU A 134
ALA A 133
LEU A 286
 None
 1.04A 5ji0A-4v1uA:
undetectable		 5ji0A-4v1uA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v1u LYND

(Lyngbya
aestuarii) 		PF02624
(YcaO) 		5 ILE A 264
GLN A 258
LEU A 134
ALA A 133
VAL A 195
 None
 1.16A 5ji0A-4v1uA:
undetectable		 5ji0A-4v1uA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w5k ASPARTATE
AMINOTRANSFERASE,
MITOCHONDRIAL

(Trypanosoma
brucei) 		PF00155
(Aminotran_1_2) 		5 ILE A 230
GLN A 233
LEU A 249
ALA A 248
VAL A 164
 None
 1.20A 5ji0A-4w5kA:
undetectable		 5ji0A-4w5kA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4weo PUTATIVE
ACETOIN(DIACETYL)
REDUCTASE

(Burkholderia
cenocepacia) 		PF00106
(adh_short) 		5 ILE A  23
LEU A  36
LEU A  27
ALA A  28
VAL A 141
 None
 1.06A 5ji0A-4weoA:
undetectable		 5ji0A-4weoA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ypl LON PROTEASE

(Meiothermus
taiwanensis) 		PF00004
(AAA)
PF05362
(Lon_C) 		5 ILE A 687
PHE A 657
LEU A 663
ALA A 616
LEU A 766
 None
 1.23A 5ji0A-4yplA:
undetectable		 5ji0A-4yplA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zaj ARGININE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		PF00750
(tRNA-synt_1d)
PF03485
(Arg_tRNA_synt_N)
PF05746
(DALR_1) 		5 ILE A 431
LEU A 398
LEU A 254
ALA A 253
LEU A 452
 None
 1.10A 5ji0A-4zajA:
undetectable		 5ji0A-4zajA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cde PROLINE DIPEPTIDASE

(Xanthomonas
campestris) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		5 ILE A 279
LEU A 373
LEU A 282
ALA A 285
LEU A 247
 None
 1.11A 5ji0A-5cdeA:
undetectable		 5ji0A-5cdeA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cvo UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 46

(Homo sapiens) 		PF00443
(UCH) 		5 ILE B 250
GLN B 173
LEU B 196
VAL B 299
LEU B  53
 None
 1.03A 5ji0A-5cvoB:
undetectable		 5ji0A-5cvoB:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gs0 TOLL-LIKE RECEPTOR 3

(Homo sapiens) 		PF13516
(LRR_6)
PF13855
(LRR_8) 		5 ILE A 591
TRP A 546
PHE A 606
LEU A 612
LEU A 569
 None
 1.23A 5ji0A-5gs0A:
undetectable		 5ji0A-5gs0A:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h7d PUTRESCINE
AMINOTRANSFERASE,IMM
UNOGLOBULIN
G-BINDING PROTEIN A

(Escherichia
coli;
Staphylococcus
aureus) 		PF00202
(Aminotran_3)
PF02216
(B) 		5 ILE A 442
LEU A 367
PHE A 370
LEU A 373
ALA A 374
 None
 1.18A 5ji0A-5h7dA:
undetectable		 5ji0A-5h7dA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jcn OS09G0567300 PROTEIN

(Oryza sativa) 		PF07992
(Pyr_redox_2) 		5 ILE A 255
LEU A 146
LEU A 183
ALA A 182
VAL A 240
 None
FAD  A 500 ( 4.6A)
None
None
None
 1.13A 5ji0A-5jcnA:
undetectable		 5ji0A-5jcnA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k1c UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 12

(Homo sapiens) 		PF00443
(UCH) 		5 ILE A 254
GLN A 177
LEU A 200
VAL A 303
LEU A  57
 None
 1.20A 5ji0A-5k1cA:
undetectable		 5ji0A-5k1cA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l51 (-)-MENTHONE:(+)-NEO
MENTHOL REDUCTASE

(Mentha x
piperita) 		PF00106
(adh_short)
PF13561
(adh_short_C2) 		5 ILE A  29
LEU A  42
LEU A  33
ALA A  34
VAL A 186
 None
 0.99A 5ji0A-5l51A:
undetectable		 5ji0A-5l51A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lcx (-)-ISOPIPERITENONE
REDUCTASE

(Mentha x
piperita) 		PF00106
(adh_short) 		5 ILE A  21
LEU A  34
LEU A  25
ALA A  26
VAL A 180
 None
None
None
None
NAP  A 400 (-4.0A)
 1.02A 5ji0A-5lcxA:
undetectable		 5ji0A-5lcxA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oev GLUTATHIONE
SYNTHETASE-LIKE
EFFECTOR 22
(GPA-GSS22-APO)

(Globodera
pallida) 		no annotation 5 ILE A 295
LEU A 306
ALA A 114
VAL A 213
LEU A 248
 None
 1.20A 5ji0A-5oevA:
undetectable		 5ji0A-5oevA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oqp CONDENSIN COMPLEX
SUBUNIT 3

(Saccharomyces
cerevisiae) 		no annotation 5 LEU A 626
LEU A 606
ALA A 610
VAL A 479
LEU A 593
 None
 1.14A 5ji0A-5oqpA:
undetectable		 5ji0A-5oqpA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5thk PUTATIVE
DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF13561
(adh_short_C2) 		5 ILE A  92
LEU A   6
ALA A   7
VAL A 142
LEU A 135
 None
 1.23A 5ji0A-5thkA:
undetectable		 5ji0A-5thkA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tou PHYCOCYANIN BETA-1
SUBUNIT

(Pseudanabaena
sp. lw0831) 		no annotation 5 ILE D 131
LEU D  90
ALA D  55
CYH D 109
LEU D 105
 None
None
None
CYC  D 202 ( 3.9A)
None
 1.24A 5ji0A-5touD:
undetectable		 5ji0A-5touD:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tvd TM16

(Trichuris muris) 		PF01161
(PBP) 		5 GLN A 173
LEU A 171
LEU A  45
CYH A  29
LEU A  28
 None
 0.89A 5ji0A-5tvdA:
undetectable		 5ji0A-5tvdA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u4h UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Acinetobacter
baumannii) 		PF00275
(EPSP_synthase) 		5 ILE A  33
LEU A  98
ALA A 173
VAL A  62
LEU A  56
 None
 1.18A 5ji0A-5u4hA:
undetectable		 5ji0A-5u4hA:
22.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uan RETINOIC ACID
RECEPTOR RXR-ALPHA

(Homo sapiens) 		no annotation 11 ILE A 268
GLN A 275
TRP A 305
LEU A 309
PHE A 313
ARG A 316
LEU A 326
ALA A 327
VAL A 342
CYH A 432
LEU A 436
 9CR  A 503 (-4.0A)
9CR  A 503 (-3.8A)
None
9CR  A 503 (-3.7A)
9CR  A 503 (-4.7A)
9CR  A 503 (-3.0A)
9CR  A 503 (-4.3A)
9CR  A 503 (-3.4A)
None
9CR  A 503 (-3.3A)
9CR  A 503 ( 4.8A)
 0.64A 5ji0A-5uanA:
32.7		 5ji0A-5uanA:
91.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uou 2-OXO-4-HYDROXY-4-CA
RBOXY-5-UREIDOIMIDAZ
OLINE (OHCU)
DECARBOXYLASE

(Klebsiella
pneumoniae) 		PF09349
(OHCU_decarbox) 		5 GLN A   6
LEU A  10
PHE A   7
LEU A   4
ALA A   3
 None
 1.16A 5ji0A-5uouA:
undetectable		 5ji0A-5uouA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wgc DAUNORUBICIN-DOXORUB
ICIN POLYKETIDE
SYNTHASE

(Streptomyces
peucetius) 		no annotation 5 ILE A 259
LEU A 324
LEU A 249
ALA A 248
LEU A 316
 None
 1.19A 5ji0A-5wgcA:
undetectable		 5ji0A-5wgcA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6acd -

(-) 		no annotation 5 ILE A 724
LEU A 959
LEU A 735
VAL A 718
LEU A 948
 None
 1.10A 5ji0A-6acdA:
undetectable		 5ji0A-6acdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bpz PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT
1,PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT
1,MOUSE
PIEZO1,PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT
1,PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT 1

(Mus musculus) 		no annotation 5 ILE A2403
LEU A2232
LEU A2357
ALA A2355
LEU A2371
 None
 1.22A 5ji0A-6bpzA:
undetectable		 5ji0A-6bpzA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c49 ALCOHOL
DEHYDROGENASE

(Acinetobacter
baumannii) 		no annotation 6 ILE A 156
TRP A 192
LEU A 163
LEU A 294
ALA A 292
LEU A 188
 None
 1.39A 5ji0A-6c49A:
undetectable		 5ji0A-6c49A:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c66 CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY

(Thermobifida
fusca) 		no annotation 5 ILE A  71
LEU A 273
ALA A 268
VAL A 182
LEU A  44
 None
 1.03A 5ji0A-6c66A:
undetectable		 5ji0A-6c66A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f3m -

(-) 		no annotation 5 LEU B 396
LEU B  38
ALA B  37
VAL B  80
LEU B  51
 None
 1.18A 5ji0A-6f3mB:
undetectable		 5ji0A-6f3mB:
undetectable