SIMILAR PATTERNS OF AMINO ACIDS FOR 5JHD_J_EDTJ301_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eth TRIACYLGLYCEROL
ACYL-HYDROLASE

(Sus scrofa) 		PF00151
(Lipase)
PF01477
(PLAT) 		4 TYR A  42
GLU A  83
GLY A  82
SER A  88
 None
 1.48A 5jhdJ-1ethA:
1.6		 5jhdJ-1ethA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ile ISOLEUCYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1) 		4 TYR A 650
GLU A   4
GLY A   6
SER A 651
 None
 1.50A 5jhdJ-1ileA:
0.0		 5jhdJ-1ileA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nnw HYPOTHETICAL PROTEIN

(Pyrococcus
furiosus) 		no annotation 4 TYR A 138
LYS A  72
GLY A 147
SER A 175
 None
 1.07A 5jhdJ-1nnwA:
0.0		 5jhdJ-1nnwA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qez PROTEIN (INORGANIC
PYROPHOSPHATASE)

(Sulfolobus
acidocaldarius) 		PF00719
(Pyrophosphatase) 		4 TYR A1048
LYS A1026
GLU A1018
GLY A1053
 None
 1.13A 5jhdJ-1qezA:
0.0		 5jhdJ-1qezA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sp3 CYTOCHROME C,
PUTATIVE

(Shewanella
oneidensis) 		PF11783
(Cytochrome_cB)
PF13435
(Cytochrome_C554) 		4 TYR A 108
LYS A 110
GLU A 117
GLY A  15
 None
 1.36A 5jhdJ-1sp3A:
0.0		 5jhdJ-1sp3A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t0b THUA-LIKE PROTEIN

(Geobacillus
stearothermophilus) 		PF06283
(ThuA) 		4 TYR A 155
GLU A 152
GLY A 198
SER A 102
 None
None
None
ZN  A3001 ( 4.0A)
 1.27A 5jhdJ-1t0bA:
0.0		 5jhdJ-1t0bA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uwi BETA-GALACTOSIDASE

(Sulfolobus
solfataricus) 		PF00232
(Glyco_hydro_1) 		4 TYR A 321
GLU A 362
GLY A 341
SER A 265
 None
 1.16A 5jhdJ-1uwiA:
0.0		 5jhdJ-1uwiA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v0b CELL DIVISION
CONTROL PROTEIN 2
HOMOLOG

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		4 TYR A  19
LYS A   9
GLU A  12
GLY A  16
 None
 0.82A 5jhdJ-1v0bA:
0.0		 5jhdJ-1v0bA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vec ATP-DEPENDENT RNA
HELICASE P54

(Homo sapiens) 		PF00270
(DEAD) 		4 TYR A 139
GLU A 236
GLY A 132
SER A 136
 None
 1.32A 5jhdJ-1vecA:
0.0		 5jhdJ-1vecA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vrq SARCOSINE OXIDASE
ALPHA SUBUNIT

(Corynebacterium
sp. U-96) 		PF01571
(GCV_T)
PF08669
(GCV_T_C)
PF12831
(FAD_oxidored)
PF13510
(Fer2_4) 		4 TYR A 274
GLU A 168
GLY A 269
SER A  65
 None
 1.48A 5jhdJ-1vrqA:
undetectable		 5jhdJ-1vrqA:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bqx INORGANIC
PYROPHOSPHATASE

(Helicobacter
pylori) 		PF00719
(Pyrophosphatase) 		4 TYR A  50
LYS A  28
GLU A  20
GLY A  55
 None
 1.16A 5jhdJ-2bqxA:
undetectable		 5jhdJ-2bqxA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fyx TRANSPOSASE,
PUTATIVE

(Deinococcus
radiodurans) 		PF01797
(Y1_Tnp) 		4 TYR A   9
LYS A   2
GLU A  48
GLY A  64
 None
GOL  A 135 (-3.8A)
GOL  A 135 (-3.8A)
GOL  A 135 (-3.9A)
 1.24A 5jhdJ-2fyxA:
undetectable		 5jhdJ-2fyxA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2je2 CYTOCHROME P460

(Nitrosomonas
europaea) 		PF16694
(Cytochrome_P460) 		4 TYR A  53
LYS A  57
GLU A 165
GLY A 167
 None
 1.39A 5jhdJ-2je2A:
undetectable		 5jhdJ-2je2A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jg7 ANTIQUITIN

(Acanthopagrus
schlegelii) 		PF00171
(Aldedh) 		4 TYR A 487
GLU A 267
GLY A 476
SER A 483
 None
NAD  A1510 (-3.9A)
None
None
 1.18A 5jhdJ-2jg7A:
undetectable		 5jhdJ-2jg7A:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qq6 MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME-LIKE PROTEIN

(Rubrobacter
xylanophilus) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 TYR A 269
LYS A 292
GLU A 266
GLY A 265
 None
None
MG  A 409 (-2.4A)
None
 1.44A 5jhdJ-2qq6A:
undetectable		 5jhdJ-2qq6A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xub DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC3

(Homo sapiens) 		PF05645
(RNA_pol_Rpc82)
PF08221
(HTH_9) 		4 TYR A 334
LYS A 325
GLY A 330
SER A 290
 None
 1.02A 5jhdJ-2xubA:
undetectable		 5jhdJ-2xubA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yk0 ERYTHROCYTE MEMBRANE
PROTEIN 1

(Plasmodium
falciparum) 		PF03011
(PFEMP)
PF05424
(Duffy_binding)
PF15447
(NTS) 		4 TYR A  98
LYS A  95
GLU A  92
GLY A  89
 None
 1.37A 5jhdJ-2yk0A:
undetectable		 5jhdJ-2yk0A:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yyl 4-HYDROXYPHENYLACETA
TE-3-HYDROXYLASE

(Thermus
thermophilus) 		PF03241
(HpaB)
PF11794
(HpaB_N) 		4 TYR A 207
GLU A 205
GLY A 203
SER A 156
 None
 1.39A 5jhdJ-2yylA:
undetectable		 5jhdJ-2yylA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yzm D-ALANINE--D-ALANINE
LIGASE

(Thermus
thermophilus) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		4 LYS A 153
GLU A 282
GLY A 158
SER A 160
 None
None
DAL  A 401 ( 4.2A)
None
 0.94A 5jhdJ-2yzmA:
undetectable		 5jhdJ-2yzmA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a21 PUTATIVE SECRETED
ALPHA-GALACTOSIDASE

(Streptomyces
avermitilis) 		PF00652
(Ricin_B_lectin)
PF16499
(Melibiase_2) 		4 TYR A 357
LYS A 346
GLU A 349
GLY A 353
 None
GOL  A 911 (-3.5A)
GOL  A 911 ( 3.0A)
None
 1.20A 5jhdJ-3a21A:
undetectable		 5jhdJ-3a21A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bjs MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Polaromonas sp.
JS666) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 TYR A 289
LYS A 312
GLU A 286
GLY A 285
 None
None
MG  A 501 (-2.5A)
None
 1.20A 5jhdJ-3bjsA:
undetectable		 5jhdJ-3bjsA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ch2 SERINE-REPEAT
ANTIGEN PROTEIN

(Plasmodium
falciparum) 		PF00112
(Peptidase_C1) 		4 LYS X 780
GLU X 778
GLY X 777
SER X 775
 None
 1.40A 5jhdJ-3ch2X:
undetectable		 5jhdJ-3ch2X:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3csq MORPHOGENESIS
PROTEIN 1

(Bacillus virus
phi29) 		no annotation 4 TYR A  87
LYS A  88
GLU A  58
GLY A  59
 None
 1.07A 5jhdJ-3csqA:
undetectable		 5jhdJ-3csqA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3csz MORPHOGENESIS
PROTEIN 1

(Bacillus virus
phi29) 		no annotation 4 TYR A  87
LYS A  88
GLU A  58
GLY A  59
 None
 1.01A 5jhdJ-3cszA:
undetectable		 5jhdJ-3cszA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gbz KINASE, CMGC CDK

(Giardia
intestinalis) 		PF00069
(Pkinase) 		4 TYR A  30
LYS A  20
GLU A  23
GLY A  27
 None
 0.66A 5jhdJ-3gbzA:
undetectable		 5jhdJ-3gbzA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iwb S-ADENOSYLMETHIONINE
DECARBOXYLASE
S-ADENOSYLMETHIONINE
DECARBOXYLASE

(Thermotoga
maritima;
Thermotoga
maritima) 		PF02675
(AdoMet_dc)
PF02675
(AdoMet_dc) 		4 TYR A 115
GLU A  85
GLY A  84
SER B   3
 None
 1.41A 5jhdJ-3iwbA:
undetectable		 5jhdJ-3iwbA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mjo RIBONUCLEOTIDE
REDUCTASE SUBUNIT
R2F

(Corynebacterium
ammoniagenes) 		PF00268
(Ribonuc_red_sm) 		4 TYR A 173
GLU A 168
GLY A 206
SER A 203
 None
MN3  A1002 (-2.9A)
None
None
 1.19A 5jhdJ-3mjoA:
undetectable		 5jhdJ-3mjoA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nx6 10KDA CHAPERONIN

(Xanthomonas
oryzae) 		PF00166
(Cpn10) 		4 TYR A  82
LYS A  13
GLY A  79
SER A  77
 None
 1.39A 5jhdJ-3nx6A:
undetectable		 5jhdJ-3nx6A:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q46 TT-IPPASE

(Thermococcus
thioreducens) 		PF00719
(Pyrophosphatase) 		4 TYR A  52
LYS A  30
GLU A  22
GLY A  57
 None
PO4  A 301 ( 2.9A)
MG  A 305 ( 4.6A)
None
 1.22A 5jhdJ-3q46A:
undetectable		 5jhdJ-3q46A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sth GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Toxoplasma
gondii) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 TYR A  93
LYS A 117
GLY A 339
SER A 335
 None
 1.39A 5jhdJ-3sthA:
undetectable		 5jhdJ-3sthA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t3o METAL DEPENDENT
HYDROLASE

(Thermus
thermophilus) 		PF07521
(RMMBL)
PF12706
(Lactamase_B_2) 		4 TYR A 430
LYS A 439
GLU A 442
GLY A 427
 None
 0.77A 5jhdJ-3t3oA:
undetectable		 5jhdJ-3t3oA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v7n THREONINE SYNTHASE

(Burkholderia
thailandensis) 		PF00291
(PALP)
PF14821
(Thr_synth_N) 		4 TYR A  32
GLU A  13
GLY A  10
SER A   5
 None
 1.08A 5jhdJ-3v7nA:
undetectable		 5jhdJ-3v7nA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ze7 PERIPLASMIC [NIFESE]
HYDROGENASE, LARGE
SUBUNIT,
SELENOCYSTEINE-CONTA
INING

(Desulfovibrio
vulgaris) 		PF00374
(NiFeSe_Hases) 		4 TYR B 298
LYS B 299
GLU B 413
GLY B 414
 None
 1.38A 5jhdJ-3ze7B:
undetectable		 5jhdJ-3ze7B:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bbw SIALIDASE
(NEURAMINIDASE)

(Bacteroides
thetaiotaomicron) 		PF13088
(BNR_2)
PF14873
(BNR_assoc_N) 		4 TYR A  79
LYS A 118
GLU A 121
SER A 147
 None
 1.31A 5jhdJ-4bbwA:
undetectable		 5jhdJ-4bbwA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bgb PUTATIVE SUGAR
KINASE MK0840

(Methanopyrus
kandleri) 		PF03702
(AnmK) 		4 LYS A 301
GLU A 323
GLY A 322
SER A 296
 ADP  A1352 (-4.6A)
None
None
None
 1.37A 5jhdJ-4bgbA:
undetectable		 5jhdJ-4bgbA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dwd MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
C-TERMINAL DOMAIN
PROTEIN

(Paracoccus
denitrificans) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 TYR A 252
LYS A 274
GLU A 249
GLY A 248
 None
None
None
CL  A 502 (-3.5A)
 1.49A 5jhdJ-4dwdA:
undetectable		 5jhdJ-4dwdA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ecp INORGANIC
PYROPHOSPHATASE

(Mycobacterium
leprae) 		PF00719
(Pyrophosphatase) 		4 TYR A  38
LYS A  16
GLU A   8
GLY A  43
 None
 1.21A 5jhdJ-4ecpA:
undetectable		 5jhdJ-4ecpA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fxg MANNAN-BINDING
LECTIN SERINE
PROTEASE 2 A CHAIN

(Homo sapiens) 		PF00084
(Sushi) 		4 TYR G 410
GLU G 424
GLY G 423
SER G 421
 None
 1.45A 5jhdJ-4fxgG:
undetectable		 5jhdJ-4fxgG:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gnx PUTATIVE
UNCHARACTERIZED
PROTEIN

(Ustilago maydis) 		PF01336
(tRNA_anti-codon)
PF08646
(Rep_fac-A_C)
PF16900
(REPA_OB_2) 		4 TYR C 274
GLU C 186
GLY C 187
SER C 189
 None
 1.48A 5jhdJ-4gnxC:
undetectable		 5jhdJ-4gnxC:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4grl MHC CLASS II
HLA-DQ-ALPHA CHAIN

(Homo sapiens) 		PF00993
(MHC_II_alpha)
PF07654
(C1-set) 		4 TYR A  13
LYS A  67
GLY A  17
SER A  19
 None
 1.07A 5jhdJ-4grlA:
12.5		 5jhdJ-4grlA:
22.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4h1l ANI2.3 TCR B CHAIN

(Escherichia
coli) 		PF07686
(V-set) 		4 TYR H  45
LYS H  55
GLY H  61
SER H  63
 None
 0.54A 5jhdJ-4h1lH:
20.7		 5jhdJ-4h1lH:
91.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ha4 BETA-GALACTOSIDASE

(Acidilobus
saccharovorans) 		PF00232
(Glyco_hydro_1) 		4 TYR A 319
GLU A 360
GLY A 339
SER A 267
 None
None
None
PG4  A 507 (-2.8A)
 1.30A 5jhdJ-4ha4A:
undetectable		 5jhdJ-4ha4A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jjp PHOSPHOMETHYLPYRIMID
INE KINASE

(Clostridioides
difficile) 		PF08543
(Phos_pyr_kin) 		4 LYS A 237
GLU A 201
GLY A 212
SER A 216
 None
 1.20A 5jhdJ-4jjpA:
undetectable		 5jhdJ-4jjpA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p4q CYTOCHROME C ISO-1

(Saccharomyces
cerevisiae) 		PF00034
(Cytochrom_C) 		4 TYR B  48
GLU B  44
GLY B  45
SER B  47
 HEM  B 201 (-4.3A)
None
None
None
 1.37A 5jhdJ-4p4qB:
undetectable		 5jhdJ-4p4qB:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pag PERIPLASMIC BINDING
PROTEIN

(Sulfurospirillum
deleyianum) 		PF01497
(Peripla_BP_2) 		4 TYR A 337
GLU A  74
GLY A  73
SER A 280
 None
 1.37A 5jhdJ-4pagA:
undetectable		 5jhdJ-4pagA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pc4 30K LIPOPROTEIN

(Bombyx mori) 		PF03260
(Lipoprotein_11) 		4 TYR A  80
LYS A  79
GLY A  41
SER A  44
 None
None
None
MES  A 302 ( 4.9A)
 1.45A 5jhdJ-4pc4A:
undetectable		 5jhdJ-4pc4A:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pxn UNCHARACTERIZED
PROTEIN

(Zea mays) 		PF00171
(Aldedh) 		4 TYR A 486
GLU A 267
GLY A 475
SER A 482
 None
NAD  A 601 (-4.3A)
None
None
 1.19A 5jhdJ-4pxnA:
undetectable		 5jhdJ-4pxnA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rgj CALCIUM-DEPENDENT
PROTEIN KINASE 4

(Plasmodium
falciparum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		4 TYR A 142
GLU A  83
GLY A  82
SER A 102
 None
 0.85A 5jhdJ-4rgjA:
undetectable		 5jhdJ-4rgjA:
17.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4zdh BETA CHAIN OF JKF6
T-CELL
RECEPTOR,PROTEIN
TRBV28

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 TYR B  47
LYS B  57
GLY B  63
SER B  65
 None
 0.54A 5jhdJ-4zdhB:
29.8		 5jhdJ-4zdhB:
77.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zk6 QUINOLINATE SYNTHASE
A

(Pyrococcus
horikoshii) 		PF02445
(NadA) 		4 TYR A 276
LYS A 275
GLU A 269
SER A  78
 None
 1.41A 5jhdJ-4zk6A:
undetectable		 5jhdJ-4zk6A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b5k IZUMO SPERM-EGG
FUSION PROTEIN 1

(Mus musculus) 		PF15005
(IZUMO)
PF16706
(Izumo-Ig) 		4 LYS A 220
GLU A 226
GLY A 224
SER A 175
 None
 1.10A 5jhdJ-5b5kA:
7.7		 5jhdJ-5b5kA:
23.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5euo PF6 TCR BETA CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 TYR F  45
LYS F  55
GLY F  61
SER F  63
 None
 0.51A 5jhdJ-5euoF:
30.7		 5jhdJ-5euoF:
95.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5for PHOSPHOINOSITIDE
3-KINASE ADAPTER
PROTEIN 1

(Homo sapiens) 		no annotation 4 TYR A  13
GLU A  47
GLY A  45
SER A  14
 None
 1.34A 5jhdJ-5forA:
undetectable		 5jhdJ-5forA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gj4 SERINE PROTEASE NS3

(Zika virus) 		PF00949
(Peptidase_S7) 		4 TYR B  23
LYS B  19
GLU B  62
GLY B  61
 None
 1.20A 5jhdJ-5gj4B:
undetectable		 5jhdJ-5gj4B:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gqr LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE TDR

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8) 		4 LYS B 321
GLU B 343
GLY B 342
SER B 318
 None
 1.04A 5jhdJ-5gqrB:
undetectable		 5jhdJ-5gqrB:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lki TCDA1

(Photorhabdus
luminescens) 		PF03538
(VRP1) 		4 TYR A1122
LYS A1146
GLY A1119
SER A1114
 None
 1.14A 5jhdJ-5lkiA:
3.1		 5jhdJ-5lkiA:
7.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ls0 SOLUBLE INORGANIC
PYROPHOSPHATASE 1

(Arabidopsis
thaliana) 		PF00719
(Pyrophosphatase) 		4 TYR A  84
LYS A  62
GLU A  54
GLY A  89
 None
None
MG  A 301 ( 4.2A)
None
 1.06A 5jhdJ-5ls0A:
undetectable		 5jhdJ-5ls0A:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m89 SPLICEOSOME WD40 SC

(Chaetomium
thermophilum) 		no annotation 4 TYR A 267
LYS A 265
GLU A 243
GLY A 242
 None
 1.46A 5jhdJ-5m89A:
undetectable		 5jhdJ-5m89A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ori ALBUMIN

(Capra hircus) 		no annotation 4 TYR A 451
GLU A 399
GLY A 430
SER A 428
 None
 1.40A 5jhdJ-5oriA:
undetectable		 5jhdJ-5oriA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y6q ALDEHYDE OXIDASE
MEDIUM SUBUNIT

(Methylobacillus
sp. KY4400) 		no annotation 4 TYR B 230
LYS B 232
GLY B 164
SER B  93
 None
FAD  B 401 (-2.7A)
FAD  B 401 (-3.4A)
None
 1.45A 5jhdJ-5y6qB:
undetectable		 5jhdJ-5y6qB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yxe SERUM ALBUMIN

(Felis catus) 		no annotation 4 TYR A 452
GLU A 400
GLY A 431
SER A 429
 None
 1.44A 5jhdJ-5yxeA:
undetectable		 5jhdJ-5yxeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5znn SORTILIN

(Mus musculus) 		no annotation 4 TYR A 504
LYS A 515
GLU A 518
GLY A 519
 None
 1.01A 5jhdJ-5znnA:
undetectable		 5jhdJ-5znnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5znn SORTILIN

(Mus musculus) 		no annotation 4 TYR A 504
LYS A 515
GLU A 518
SER A 491
 None
 1.09A 5jhdJ-5znnA:
undetectable		 5jhdJ-5znnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bdz DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 10

(Homo sapiens) 		no annotation 4 TYR A 350
LYS A 348
GLU A 345
GLY A 341
 None
 1.17A 5jhdJ-6bdzA:
undetectable		 5jhdJ-6bdzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2

(Saccharomyces
cerevisiae) 		no annotation 4 LYS A1029
GLU A1025
GLY A 986
SER A 990
 None
 1.47A 5jhdJ-6emkA:
undetectable		 5jhdJ-6emkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fq3 E3 UBIQUITIN-PROTEIN
LIGASE TRIM71

(Danio rerio) 		no annotation 4 TYR A 542
GLU A 761
GLY A 539
SER A 541
 None
 1.43A 5jhdJ-6fq3A:
4.5		 5jhdJ-6fq3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fur HUMAN F11 T-CELL
RECEPTOR

(Homo sapiens) 		no annotation 4 TYR B  46
LYS B  56
GLY B  62
SER B  64
 None
None
None
EDO  B 302 (-3.3A)
 0.62A 5jhdJ-6furB:
29.4		 5jhdJ-6furB:
undetectable