SIMILAR PATTERNS OF AMINO ACIDS FOR 5JH7_B_6K9B503_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1amk TRIOSE PHOSPHATE
ISOMERASE

(Leishmania
mexicana) 		PF00121
(TIM) 		5 VAL A 214
SER A 213
THR A 174
TYR A 210
LEU A 222
 None
PGA  A 600 (-4.2A)
None
None
None
 1.27A 5jh7B-1amkA:
undetectable		 5jh7B-1amkA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1att ANTITHROMBIN III

(Bos taurus) 		PF00079
(Serpin) 		5 ASN A 209
VAL A 365
SER A 366
ASP A 367
LEU A 352
 None
 1.43A 5jh7B-1attA:
undetectable		 5jh7B-1attA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jqo PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Zea mays) 		PF00311
(PEPcase) 		5 SER A 541
ASP A 542
GLU A 483
TYR A 587
LEU A 494
 None
 1.43A 5jh7B-1jqoA:
1.7		 5jh7B-1jqoA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lc7 L-THREONINE-O-3-PHOS
PHATE DECARBOXYLASE

(Salmonella
enterica) 		PF00155
(Aminotran_1_2) 		5 VAL A 248
SER A 247
GLU A  87
TYR A  61
LEU A  64
 None
 1.27A 5jh7B-1lc7A:
2.4		 5jh7B-1lc7A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mo0 TRIOSEPHOSPHATE
ISOMERASE

(Caenorhabditis
elegans) 		PF00121
(TIM) 		5 VAL A 211
SER A 210
THR A 171
TYR A 207
LEU A 219
 None
SO4  A 901 (-3.7A)
None
None
None
 1.39A 5jh7B-1mo0A:
undetectable		 5jh7B-1mo0A:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tcd TRIOSEPHOSPHATE
ISOMERASE

(Trypanosoma
cruzi) 		PF00121
(TIM) 		5 VAL A 215
SER A 214
THR A 175
TYR A 211
LEU A 223
 None
 1.41A 5jh7B-1tcdA:
undetectable		 5jh7B-1tcdA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tmh TRIOSEPHOSPHATE
ISOMERASE

(Escherichia
coli) 		PF00121
(TIM) 		5 GLN A 184
VAL A 215
SER A 214
THR A 176
TYR A 211
 None
None
SO4  A 555 (-3.4A)
None
None
 1.47A 5jh7B-1tmhA:
undetectable		 5jh7B-1tmhA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tve HOMOSERINE
DEHYDROGENASE

(Saccharomyces
cerevisiae) 		PF00742
(Homoserine_dh)
PF03447
(NAD_binding_3) 		5 VAL A 198
SER A 195
ASP A 196
PRO A 211
LEU A 215
 None
 1.49A 5jh7B-1tveA:
undetectable		 5jh7B-1tveA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u3d CRYPTOCHROME 1
APOPROTEIN

(Arabidopsis
thaliana) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		5 ASN A 137
VAL A 259
SER A 260
ASP A  26
LEU A 250
 None
 1.45A 5jh7B-1u3dA:
undetectable		 5jh7B-1u3dA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wer P120GAP

(Homo sapiens) 		PF00616
(RasGAP) 		5 SER A 817
ASP A 816
GLU A 854
PRO A 912
LEU A 930
 None
 1.37A 5jh7B-1werA:
undetectable		 5jh7B-1werA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xip NUCLEOPORIN NUP159

(Saccharomyces
cerevisiae) 		PF16755
(NUP214) 		5 ASN A  46
VAL A 339
ASP A  43
TYR A 279
PRO A 336
 None
 1.41A 5jh7B-1xipA:
undetectable		 5jh7B-1xipA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yq9 PERIPLASMIC [NIFE]
HYDROGENASE SMALL
SUBUNIT

(Desulfovibrio
gigas) 		PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		5 VAL A  24
SER A  21
THR A  18
GLU A  73
LEU A  35
 None
None
None
SF4  A 267 ( 4.9A)
None
 1.26A 5jh7B-1yq9A:
3.2		 5jh7B-1yq9A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yya TRIOSEPHOSPHATE
ISOMERASE

(Thermus
thermophilus) 		PF00121
(TIM) 		5 VAL A 213
SER A 212
THR A 173
TYR A 209
LEU A 221
 None
PO4  A2004 (-4.0A)
None
None
None
 1.40A 5jh7B-1yyaA:
undetectable		 5jh7B-1yyaA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z3i SIMILAR TO
RAD54-LIKE

(Danio rerio) 		PF00176
(SNF2_N)
PF00271
(Helicase_C) 		5 ASN X 452
VAL X 513
SER X 514
THR X 519
LEU X 582
 None
 1.46A 5jh7B-1z3iX:
undetectable		 5jh7B-1z3iX:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2de0 ALPHA-(1,6)-FUCOSYLT
RANSFERASE

(Homo sapiens) 		PF14604
(SH3_9) 		5 VAL X 262
SER X 263
THR X 265
TYR X 334
LEU X 335
 None
 1.25A 5jh7B-2de0X:
undetectable		 5jh7B-2de0X:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eb0 MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE

(Methanocaldococcus
jannaschii) 		PF01368
(DHH)
PF02833
(DHHA2) 		5 ASN A  36
VAL A 149
SER A 146
ASP A 147
GLU A  38
 None
None
None
MN  A 502 (-2.6A)
None
 1.46A 5jh7B-2eb0A:
undetectable		 5jh7B-2eb0A:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eb0 MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE

(Methanocaldococcus
jannaschii) 		PF01368
(DHH)
PF02833
(DHHA2) 		5 ASN A  36
VAL A 149
SER A 146
THR A  12
GLU A  38
 None
 1.44A 5jh7B-2eb0A:
undetectable		 5jh7B-2eb0A:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fn9 RIBOSE ABC
TRANSPORTER,
PERIPLASMIC
RIBOSE-BINDING
PROTEIN

(Thermotoga
maritima) 		PF13407
(Peripla_BP_4) 		5 SER A  71
ASP A  67
THR A  66
GLU A  46
LEU A  97
 None
 1.30A 5jh7B-2fn9A:
3.9		 5jh7B-2fn9A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gv9 DNA POLYMERASE

(Human
alphaherpesvirus
1) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		5 ASN A 730
VAL A 258
SER A 734
THR A 735
LEU A 636
 None
 1.28A 5jh7B-2gv9A:
undetectable		 5jh7B-2gv9A:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ndh TOLL/INTERLEUKIN-1
RECEPTOR
DOMAIN-CONTAINING
ADAPTER PROTEIN

(Homo sapiens) 		PF13676
(TIR_2) 		5 VAL A 197
TYR A 195
PRO A 177
TYR A 187
LEU A 191
 None
 1.36A 5jh7B-2ndhA:
undetectable		 5jh7B-2ndhA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ohh TYPE A FLAVOPROTEIN
FPRA

(Methanothermobacter
thermautotrophicus) 		PF00258
(Flavodoxin_1)
PF00753
(Lactamase_B) 		5 ASN A  24
SER A 299
THR A  29
TYR A 332
LEU A 333
 None
 1.34A 5jh7B-2ohhA:
4.8		 5jh7B-2ohhA:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ohh TYPE A FLAVOPROTEIN
FPRA

(Methanothermobacter
thermautotrophicus) 		PF00258
(Flavodoxin_1)
PF00753
(Lactamase_B) 		5 ASN A  24
VAL A 302
SER A 299
TYR A 332
LEU A 333
 None
 1.26A 5jh7B-2ohhA:
4.8		 5jh7B-2ohhA:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p9b POSSIBLE PROLIDASE

(Bifidobacterium
longum) 		PF01979
(Amidohydro_1) 		5 SER A 296
THR A 344
GLU A 359
TYR A 449
LEU A 303
 None
 1.47A 5jh7B-2p9bA:
undetectable		 5jh7B-2p9bA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pi5 DNA-DIRECTED RNA
POLYMERASE

(Escherichia
virus T7) 		PF00940
(RNA_pol)
PF14700
(RPOL_N) 		5 GLN A  36
VAL A 429
SER A 430
TYR A 286
LEU A 294
 None
 1.23A 5jh7B-2pi5A:
undetectable		 5jh7B-2pi5A:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pwj MITOCHONDRIAL
PEROXIREDOXIN

(Pisum sativum) 		PF08534
(Redoxin) 		5 GLN A  19
ASN A  38
VAL A 142
ASP A 144
TYR A 141
 None
 1.49A 5jh7B-2pwjA:
undetectable		 5jh7B-2pwjA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qj8 MLR6093 PROTEIN

(Mesorhizobium
japonicum) 		PF04952
(AstE_AspA) 		5 GLN A  75
VAL A 132
ASP A 134
THR A 135
LEU A  11
 None
 1.47A 5jh7B-2qj8A:
4.8		 5jh7B-2qj8A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qk7 GAMMA-HEMOLYSIN
COMPONENT A

(Staphylococcus
aureus) 		PF07968
(Leukocidin) 		5 GLN A  77
ASN A 258
VAL A 154
SER A  81
THR A 228
 None
 1.48A 5jh7B-2qk7A:
undetectable		 5jh7B-2qk7A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rfq 3-HSA HYDROXYLASE,
OXYGENASE

(Rhodococcus
jostii) 		PF02771
(Acyl-CoA_dh_N)
PF08028
(Acyl-CoA_dh_2) 		5 VAL A 104
ASP A 108
THR A 109
PRO A 169
LEU A 167
 None
 1.32A 5jh7B-2rfqA:
undetectable		 5jh7B-2rfqA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v4n MULTIFUNCTIONAL
PROTEIN SUR E

(Salmonella
enterica) 		PF01975
(SurE) 		5 ASN A  96
VAL A  88
SER A  89
THR A 106
LEU A 142
 PO4  A1257 (-3.2A)
None
None
None
None
 1.42A 5jh7B-2v4nA:
undetectable		 5jh7B-2v4nA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xn1 ALPHA-GALACTOSIDASE

(Lactobacillus
acidophilus) 		PF02065
(Melibiase)
PF16874
(Glyco_hydro_36C)
PF16875
(Glyco_hydro_36N) 		5 GLN A 168
VAL A 139
THR A 136
TYR A 108
LEU A 141
 None
None
None
None
GOL  A1736 ( 3.3A)
 1.34A 5jh7B-2xn1A:
undetectable		 5jh7B-2xn1A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyb LACCASE

(Trametes
cinnabarina) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 ASN A 275
SER A 166
ASP A 150
THR A 169
PRO A 160
 None
 1.41A 5jh7B-2xybA:
undetectable		 5jh7B-2xybA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yok EXOGLUCANASE 1

(Trichoderma
harzianum) 		PF00840
(Glyco_hydro_7) 		5 GLN A 199
ASP A 163
TYR A 184
PRO A 190
LEU A 193
 None
 1.22A 5jh7B-2yokA:
undetectable		 5jh7B-2yokA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z67 O-PHOSPHOSERYL-TRNA(
SEC) SELENIUM
TRANSFERASE

(Methanococcus
maripaludis) 		PF05889
(SepSecS) 		5 GLN A 253
ASN A 414
SER A 362
TYR A 257
LEU A 219
 None
 1.50A 5jh7B-2z67A:
undetectable		 5jh7B-2z67A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a71 EXO-ARABINANASE

(Penicillium
chrysogenum) 		no annotation 5 VAL A 371
SER A 370
GLU A 333
PRO A  26
LEU A 344
 None
 1.49A 5jh7B-3a71A:
undetectable		 5jh7B-3a71A:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bin BAND 4.1-LIKE
PROTEIN 3

(Homo sapiens) 		PF00373
(FERM_M)
PF09379
(FERM_N)
PF09380
(FERM_C) 		5 VAL A 186
THR A 154
TYR A 150
PRO A 190
LEU A 205
 None
 1.47A 5jh7B-3binA:
undetectable		 5jh7B-3binA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dev SH1221

(Staphylococcus
haemolyticus) 		PF01368
(DHH)
PF02272
(DHHA1) 		5 GLN A 112
VAL A  81
ASP A  83
TYR A 113
LEU A 101
 None
None
MG  A 323 (-2.7A)
None
None
 1.45A 5jh7B-3devA:
undetectable		 5jh7B-3devA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dul O-METHYLTRANSFERASE,
PUTATIVE

(Bacillus cereus) 		PF01596
(Methyltransf_3) 		6 VAL A  42
SER A  43
ASP A 214
THR A 207
TYR A  71
LEU A  29
 None
 1.28A 5jh7B-3dulA:
undetectable		 5jh7B-3dulA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e2d ALKALINE PHOSPHATASE

(Vibrio sp.
G15-21) 		PF00245
(Alk_phosphatase) 		5 VAL A 109
SER A 110
ASP A 111
THR A 112
LEU A 265
 None
None
None
MG  A 603 ( 4.8A)
None
 1.04A 5jh7B-3e2dA:
2.0		 5jh7B-3e2dA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ei8 LL-DIAMINOPIMELATE
AMINOTRANSFERASE

(Arabidopsis
thaliana) 		PF00155
(Aminotran_1_2) 		5 SER A 238
ASP A 237
GLU A 264
PRO A 363
TYR A 271
 GOL  A 436 (-3.4A)
PLP  A 433 (-3.1A)
GOL  A 436 (-3.3A)
None
GOL  A 436 (-4.6A)
 1.30A 5jh7B-3ei8A:
undetectable		 5jh7B-3ei8A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gr5 ESCC

(Escherichia
coli) 		no annotation 5 VAL A  63
SER A  62
GLU A 105
TYR A  87
LEU A  46
 None
 1.34A 5jh7B-3gr5A:
undetectable		 5jh7B-3gr5A:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h8l NADH OXIDASE

(Acidianus
ambivalens) 		PF07992
(Pyr_redox_2) 		5 VAL A  88
THR A 278
TYR A  90
TYR A 102
LEU A   5
 None
 1.29A 5jh7B-3h8lA:
2.3		 5jh7B-3h8lA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3irz URO-ADHERENCE FACTOR
A

(Staphylococcus
saprophyticus) 		PF17210
(SdrD_B) 		5 GLN A 686
SER A 459
THR A 458
PRO A 651
LEU A 663
 None
 1.43A 5jh7B-3irzA:
undetectable		 5jh7B-3irzA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j1c CHAPERONIN ALPHA
SUBUNIT

(Acidianus
tengchongensis) 		PF00118
(Cpn60_TCP1) 		5 VAL A 146
SER A 147
ASP A 148
PRO A 412
TYR A 200
 None
 1.16A 5jh7B-3j1cA:
undetectable		 5jh7B-3j1cA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m8y PHOSPHOPENTOMUTASE

(Bacillus cereus) 		PF01676
(Metalloenzyme) 		5 VAL A  15
THR A 340
GLU A 342
TYR A 298
LEU A 302
 None
 1.03A 5jh7B-3m8yA:
undetectable		 5jh7B-3m8yA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3on7 OXIDOREDUCTASE,
IRON/ASCORBATE
FAMILY

(Shewanella
oneidensis) 		PF03171
(2OG-FeII_Oxy)
PF14226
(DIOX_N) 		5 ASN A 113
VAL A  91
THR A 149
TYR A  89
PRO A  98
 None
 1.44A 5jh7B-3on7A:
undetectable		 5jh7B-3on7A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opy 6-PHOSPHOFRUCTO-1-KI
NASE GAMMA-SUBUNIT

(Komagataella
pastoris) 		no annotation 5 SER I 109
ASP I 106
GLU I  39
TYR I 122
LEU I 120
 None
 1.24A 5jh7B-3opyI:
undetectable		 5jh7B-3opyI:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pc3 CG1753, ISOFORM A

(Drosophila
melanogaster) 		PF00291
(PALP)
PF00571
(CBS) 		5 VAL A 424
SER A 423
ASP A 418
PRO A 415
LEU A 479
 None
 1.31A 5jh7B-3pc3A:
2.4		 5jh7B-3pc3A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r2t PUTATIVE
UNCHARACTERIZED
PROTEIN

(Staphylococcus
aureus) 		PF02876
(Stap_Strp_tox_C)
PF09199
(SSL_OB) 		5 VAL A 122
ASP A 102
GLU A 162
TYR A  94
LEU A  86
 None
 1.12A 5jh7B-3r2tA:
undetectable		 5jh7B-3r2tA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqo CYSTEINYL-TRNA
SYNTHETASE

(Coxiella
burnetii) 		PF01406
(tRNA-synt_1e)
PF09190
(DALR_2) 		5 ASN A  -1
VAL A   3
SER A   2
TYR A  60
LEU A  55
 None
 1.19A 5jh7B-3tqoA:
undetectable		 5jh7B-3tqoA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vm7 ALPHA-AMYLASE

(Malbranchea
cinnamomea) 		PF00128
(Alpha-amylase)
PF09260
(DUF1966) 		5 ASN A 394
VAL A 449
ASP A 482
TYR A 443
LEU A 466
 None
 1.22A 5jh7B-3vm7A:
undetectable		 5jh7B-3vm7A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wbh ALKALINE PHOSPHATASE

(Halomonas sp.
#593) 		PF00245
(Alk_phosphatase) 		5 VAL A 109
SER A 110
ASP A 111
THR A 112
LEU A 261
 None
None
None
MG  A 501 ( 4.8A)
None
 1.07A 5jh7B-3wbhA:
2.0		 5jh7B-3wbhA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x1b LACCASE

(Lentinus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 ASN A 296
SER A 187
ASP A 171
THR A 190
PRO A 181
 None
 1.40A 5jh7B-3x1bA:
undetectable		 5jh7B-3x1bA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zgb PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Flaveria
pringlei) 		PF00311
(PEPcase) 		5 SER A 535
ASP A 536
GLU A 477
TYR A 581
LEU A 488
 None
 1.36A 5jh7B-3zgbA:
undetectable		 5jh7B-3zgbA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4btp P1

(Pseudomonas
phage phi8) 		no annotation 5 VAL A 510
SER A 509
ASP A 501
TYR A 515
LEU A 567
 None
 1.24A 5jh7B-4btpA:
undetectable		 5jh7B-4btpA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c3h DNA-DIRECTED RNA
POLYMERASE I SUBUNIT
RPA190

(Saccharomyces
cerevisiae) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		5 ASN A 493
VAL A 812
SER A 811
THR A 492
GLU A 491
 None
 1.46A 5jh7B-4c3hA:
undetectable		 5jh7B-4c3hA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c4o CARBONYL REDUCTASE
CPCR2

(Candida
parapsilosis) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 ASN A 290
VAL A  87
SER A 138
TYR A  81
LEU A  34
 None
 1.20A 5jh7B-4c4oA:
undetectable		 5jh7B-4c4oA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c51 CATALASE-PEROXIDASE

(Mycobacterium
tuberculosis) 		PF00141
(peroxidase) 		5 ASN A 493
VAL A 538
SER A 539
THR A 572
LEU A 458
 None
 1.20A 5jh7B-4c51A:
undetectable		 5jh7B-4c51A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cr4 26S PROTEASE
REGULATORY SUBUNIT 8
HOMOLOG

(Saccharomyces
cerevisiae) 		PF00004
(AAA) 		5 GLN J 220
VAL J 213
SER J 214
GLU J 249
LEU J 233
 None
 1.20A 5jh7B-4cr4J:
undetectable		 5jh7B-4cr4J:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dkd INTERLEUKIN-34

(Homo sapiens) 		PF15036
(IL34) 		5 ASN A 155
VAL A 105
SER A 104
ASP A 107
LEU A 165
 None
 1.16A 5jh7B-4dkdA:
undetectable		 5jh7B-4dkdA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gc5 DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL

(Mus musculus) 		PF00398
(RrnaAD) 		5 GLN A  35
VAL A  84
THR A  70
GLU A  61
TYR A 115
 ACT  A 402 (-3.6A)
None
None
None
None
 1.46A 5jh7B-4gc5A:
undetectable		 5jh7B-4gc5A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jgh CULLIN-5

(Homo sapiens) 		PF00888
(Cullin) 		5 GLN D  63
VAL D 135
ASP D 141
THR D 142
LEU D 114
 None
 1.36A 5jh7B-4jghD:
undetectable		 5jh7B-4jghD:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ldp NDP-FOROSAMYLTRANSFE
RASE

(Saccharopolyspora
spinosa) 		PF06722
(DUF1205) 		5 GLN A 347
VAL A 248
THR A 251
PRO A 246
LEU A 391
 None
 1.36A 5jh7B-4ldpA:
4.5		 5jh7B-4ldpA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lw6 BETA-4-GALACTOSYLTRA
NSFERASE 7

(Drosophila
melanogaster) 		PF02709
(Glyco_transf_7C)
PF13733
(Glyco_transf_7N) 		5 GLN A 203
VAL A 274
ASP A 272
TYR A 276
LEU A 298
 None
 1.42A 5jh7B-4lw6A:
undetectable		 5jh7B-4lw6A:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4miv N-SULPHOGLUCOSAMINE
SULPHOHYDROLASE

(Homo sapiens) 		PF00884
(Sulfatase)
PF16347
(DUF4976) 		5 GLN A 239
SER A 272
ASP A 273
GLU A 292
LEU A  50
 None
None
CA  A 601 (-2.3A)
None
None
 1.49A 5jh7B-4mivA:
undetectable		 5jh7B-4mivA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n7t PHOSPHOPENTOMUTASE

(Streptococcus
mutans) 		PF01676
(Metalloenzyme) 		5 VAL A  15
THR A 352
GLU A 354
TYR A 310
LEU A 314
 None
 1.04A 5jh7B-4n7tA:
undetectable		 5jh7B-4n7tA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n9f CULLIN-5

(Homo sapiens) 		no annotation 5 GLN U  63
VAL U 135
ASP U 141
THR U 142
LEU U 114
 None
 1.30A 5jh7B-4n9fU:
undetectable		 5jh7B-4n9fU:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4np6 ADENYLATE KINASE

(Vibrio cholerae) 		PF00406
(ADK)
PF05191
(ADK_lid) 		5 VAL A 106
ASP A 104
TYR A 182
PRO A  87
LEU A   6
 None
 1.05A 5jh7B-4np6A:
3.0		 5jh7B-4np6A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p6y AMINOPEPTIDASE

(Thermotoga
maritima) 		PF05343
(Peptidase_M42) 		5 VAL A 299
SER A 300
ASP A 220
THR A 222
LEU A 261
 None
 1.30A 5jh7B-4p6yA:
undetectable		 5jh7B-4p6yA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qji PHOSPHOPANTOTHENOYLC
YSTEINE
DECARBOXYLASE/PHOSPH
OPANTOTHENATE--CYSTE
INE LIGASE

(Mycolicibacterium
smegmatis) 		PF04127
(DFP) 		5 ASN A 307
VAL A 263
ASP A 261
THR A 257
LEU A 273
 None
 1.50A 5jh7B-4qjiA:
5.2		 5jh7B-4qjiA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v20 CELLOBIOHYDROLASE

(Aspergillus
fumigatus) 		PF00840
(Glyco_hydro_7) 		5 GLN A 186
ASP A 150
TYR A 171
PRO A 177
LEU A 180
 None
 1.23A 5jh7B-4v20A:
undetectable		 5jh7B-4v20A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y96 TRIOSEPHOSPHATE
ISOMERASE

(Gemmata
obscuriglobus) 		PF00121
(TIM) 		5 VAL A 218
SER A 217
THR A 178
TYR A 214
LEU A 226
 None
PO4  A 303 (-3.8A)
None
None
None
 1.34A 5jh7B-4y96A:
undetectable		 5jh7B-4y96A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b5r GASDERMIN-A3

(Mus musculus) 		PF04598
(Gasdermin) 		5 VAL A 120
SER A 119
THR A 117
GLU A 156
LEU A 125
 None
 1.35A 5jh7B-5b5rA:
undetectable		 5jh7B-5b5rA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b8c PEMBROLIZUMAB LIGHT
CHAIN VARIABLE
REGION (PEMVL)
PEMBROLIZUMAB HEAVY
CHAIN VARIABLE
REGION (PEMVH)

(Homo sapiens;
Homo sapiens) 		PF07686
(V-set)
PF07686
(V-set) 		5 ASN B  59
VAL B  37
TYR B  95
PRO A  48
LEU B  45
 None
 1.48A 5jh7B-5b8cB:
undetectable		 5jh7B-5b8cB:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e4r KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans) 		PF01450
(IlvC)
PF07991
(IlvN) 		5 VAL A 398
SER A 399
ASP A 400
THR A 401
PRO A 135
 40E  A 504 ( 3.7A)
40E  A 504 ( 2.5A)
NAP  A 501 ( 4.4A)
None
None
 1.44A 5jh7B-5e4rA:
undetectable		 5jh7B-5e4rA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eyw TRIOSEPHOSPHATE
ISOMERASE

(Litopenaeus
vannamei) 		PF00121
(TIM) 		5 VAL A 213
SER A 212
THR A 173
TYR A 209
LEU A 221
 None
PGA  A 301 (-3.6A)
None
None
None
 1.39A 5jh7B-5eywA:
undetectable		 5jh7B-5eywA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5flw EXO-BETA-1,3-GALACTA
NASE

(Bifidobacterium
bifidum) 		PF04616
(Glyco_hydro_43) 		5 SER A 295
ASP A 296
THR A 297
PRO A 235
LEU A 292
 None
 1.40A 5jh7B-5flwA:
undetectable		 5jh7B-5flwA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5g PUTATIVE XANTHINE
DEHYDROGENASE YAGS
FAD-BINDING SUBUNIT

(Escherichia
coli) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		5 ASN C 210
VAL C 268
SER C 195
THR C 208
LEU C 114
 None
 1.33A 5jh7B-5g5gC:
undetectable		 5jh7B-5g5gC:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzp TRIOSEPHOSPHATE
ISOMERASE

(Plasmodium
falciparum) 		PF00121
(TIM) 		5 VAL A 212
SER A 211
THR A 172
TYR A 208
LEU A 220
 None
PGA  A 301 (-3.6A)
None
None
None
 1.35A 5jh7B-5gzpA:
undetectable		 5jh7B-5gzpA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hy5 TRYPTOPHAN
6-HALOGENASE

(Streptomyces
toxytricini) 		PF04820
(Trp_halogenase) 		5 VAL A 350
SER A 344
PRO A 382
TYR A 394
LEU A 377
 None
 1.35A 5jh7B-5hy5A:
undetectable		 5jh7B-5hy5A:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ic5 CANDIDATE RESPONSE
REGULATOR, CHEY

(Ramlibacter
tataouinensis) 		PF00072
(Response_reg) 		5 VAL A 103
SER A 100
ASP A 101
TYR A 106
LEU A  76
 None
 1.46A 5jh7B-5ic5A:
3.8		 5jh7B-5ic5A:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5u RAGB/SUSD DOMAIN
PROTEIN

(Flavobacterium
johnsoniae) 		PF12771
(SusD-like_2) 		5 GLN A 164
SER A 441
GLU A 438
PRO A 466
LEU A 469
 None
 1.42A 5jh7B-5j5uA:
1.4		 5jh7B-5j5uA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jw7 E3 UBIQUITIN-PROTEIN
LIGASE SOPA
E3 UBIQUITIN-PROTEIN
LIGASE TRIM56

(Salmonella
enterica;
Homo sapiens) 		PF13599
(Pentapeptide_4)
PF13981
(SopA)
PF13445
(zf-RING_UBOX) 		5 VAL A 317
SER A 318
GLU B  58
PRO A 314
LEU A 294
 None
 1.49A 5jh7B-5jw7A:
undetectable		 5jh7B-5jw7A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kel EBOLA SURFACE
GLYCOPROTEIN, GP1

(Zaire
ebolavirus) 		PF01611
(Filo_glycop) 		5 GLN A 251
ASN A 107
ASP A  78
THR A  77
LEU A 256
 None
 1.36A 5jh7B-5kelA:
undetectable		 5jh7B-5kelA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ljo OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA

(Escherichia
coli) 		PF01103
(Bac_surface_Ag)
PF07244
(POTRA) 		5 GLN A 179
VAL A 245
SER A 246
THR A 248
LEU A 219
 None
 1.34A 5jh7B-5ljoA:
undetectable		 5jh7B-5ljoA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lmc ANAEROBIC NITRIC
OXIDE REDUCTASE
FLAVORUBREDOXIN

(Escherichia
coli) 		PF00258
(Flavodoxin_1)
PF00301
(Rubredoxin)
PF00753
(Lactamase_B) 		5 GLN A 170
ASN A  36
ASP A  83
TYR A 194
LEU A 199
 None
None
FEO  A 501 ( 2.5A)
None
None
 1.48A 5jh7B-5lmcA:
5.1		 5jh7B-5lmcA:
21.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5nd4 TUBULIN ALPHA CHAIN

(Bos taurus) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		5 GLN A  11
GLU A 183
PRO A 222
TYR A 224
LEU A 227
 GTP  A 500 ( 3.1A)
GTP  A 500 (-3.3A)
None
GTP  A 500 (-3.2A)
GTP  A 500 ( 4.1A)
 0.77A 5jh7B-5nd4A:
51.3		 5jh7B-5nd4A:
38.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o5d GLUCANASE

(Trichoderma
atroviride) 		no annotation 5 GLN A 186
ASP A 150
TYR A 171
PRO A 177
LEU A 180
 None
 1.20A 5jh7B-5o5dA:
undetectable		 5jh7B-5o5dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5of4 TFIIH BASAL
TRANSCRIPTION FACTOR
COMPLEX HELICASE XPD
SUBUNIT

(Homo sapiens) 		PF06733
(DEAD_2)
PF06777
(HBB)
PF13307
(Helicase_C_2) 		5 VAL B  83
THR B  76
GLU B  79
TYR B  72
LEU B  53
 None
 1.39A 5jh7B-5of4B:
undetectable		 5jh7B-5of4B:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u9z PHOSPHOGLYCEROL
TRANSFERASE

(Streptococcus
pyogenes) 		no annotation 5 SER A 491
ASP A 733
THR A 732
TYR A 679
LEU A 676
 None
 1.30A 5jh7B-5u9zA:
2.0		 5jh7B-5u9zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5upr TRIOSEPHOSPHATE
ISOMERASE

(Toxoplasma
gondii) 		PF00121
(TIM) 		5 VAL A 336
SER A 335
THR A 296
TYR A 332
LEU A 344
 None
SO4  A 401 (-3.7A)
None
None
None
 1.47A 5jh7B-5uprA:
undetectable		 5jh7B-5uprA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ur2 BIFUNCTIONAL PROTEIN
PUTA

(Bdellovibrio
bacteriovorus) 		PF00171
(Aldedh)
PF01619
(Pro_dh) 		5 VAL A 195
SER A 194
ASP A 141
THR A 139
LEU A 220
 None
 1.35A 5jh7B-5ur2A:
2.4		 5jh7B-5ur2A:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uto EDD DOMAIN PROTEIN,
DEGV FAMILY

(Staphylococcus
aureus) 		no annotation 5 VAL A 222
ASP A 224
TYR A 280
TYR A 256
LEU A 230
 None
 1.40A 5jh7B-5utoA:
2.2		 5jh7B-5utoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wiv D(4) DOPAMINE
RECEPTOR, SOLUBLE
CYTOCHROME B562
CHIMERA

(Escherichia
coli;
Homo sapiens) 		no annotation 5 ASN A 125
VAL A 166
SER A 163
THR A 159
PRO A 169
 None
OLA  A1209 ( 4.9A)
None
None
None
 1.22A 5jh7B-5wivA:
undetectable		 5jh7B-5wivA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x5y PROBABLE ATP-BINDING
COMPONENT OF ABC
TRANSPORTER

(Pseudomonas
aeruginosa) 		no annotation 5 VAL B 197
ASP B 194
THR B 193
TYR B 234
LEU B 235
 None
 1.11A 5jh7B-5x5yB:
undetectable		 5jh7B-5x5yB:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yd5 SCFV 4B08

(Mus musculus) 		no annotation 5 GLN A 235
VAL A  39
TYR A  97
PRO A 189
LEU A  47
 None
 1.46A 5jh7B-5yd5A:
undetectable		 5jh7B-5yd5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ze8 CYTOCHROME C552

(Thermochromatium
tepidum) 		no annotation 5 VAL A  40
SER A  41
GLU A 123
PRO A 208
LEU A 210
 None
None
None
None
HEM  A 501 (-4.6A)
 1.19A 5jh7B-5ze8A:
undetectable		 5jh7B-5ze8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cnk IGG1 KAPPA LIGHT
CHAIN
IGG1 HEAVY CHAIN

(Mus musculus;
Mus musculus) 		no annotation
no annotation 		5 ASN G  60
VAL G  38
TYR G  96
PRO F  49
LEU G  46
 None
 1.34A 5jh7B-6cnkG:
undetectable		 5jh7B-6cnkG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cpy GRMZM2G135359
PSEUDOKINASE

(Zea mays) 		no annotation 5 VAL A 362
SER A 359
ASP A 358
GLU A 411
LEU A 364
 None
 1.41A 5jh7B-6cpyA:
undetectable		 5jh7B-6cpyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ek2 SINGLE CHAIN FV
FRAGMENT

(Mus musculus) 		no annotation 5 VAL H 206
THR H 219
TYR H 264
PRO H 382
LEU H 214
 None
 1.41A 5jh7B-6ek2H:
undetectable		 5jh7B-6ek2H:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6flx ABC TRANSPORTER
SYSTEM, ATP-BINDING
PROTEIN

(Burkholderia
pseudomallei) 		no annotation 5 VAL A 230
ASP A 227
THR A 226
TYR A 267
LEU A 268
 None
 1.14A 5jh7B-6flxA:
undetectable		 5jh7B-6flxA:
undetectable