SIMILAR PATTERNS OF AMINO ACIDS FOR 5JH7_B_6K9B503

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1amk TRIOSE PHOSPHATE
ISOMERASE

(Leishmania
mexicana) 		PF00121
(TIM) 		5 VAL A 214
SER A 213
THR A 174
TYR A 210
LEU A 222
 None
PGA  A 600 (-4.2A)
None
None
None
 1.27A 5jh7B-1amkA:
undetectable		 5jh7B-1amkA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1att ANTITHROMBIN III

(Bos taurus) 		PF00079
(Serpin) 		5 ASN A 209
VAL A 365
SER A 366
ASP A 367
LEU A 352
 None
 1.43A 5jh7B-1attA:
undetectable		 5jh7B-1attA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jqo PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Zea mays) 		PF00311
(PEPcase) 		5 SER A 541
ASP A 542
GLU A 483
TYR A 587
LEU A 494
 None
 1.43A 5jh7B-1jqoA:
1.7		 5jh7B-1jqoA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lc7 L-THREONINE-O-3-PHOS
PHATE DECARBOXYLASE

(Salmonella
enterica) 		PF00155
(Aminotran_1_2) 		5 VAL A 248
SER A 247
GLU A  87
TYR A  61
LEU A  64
 None
 1.27A 5jh7B-1lc7A:
2.4		 5jh7B-1lc7A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mo0 TRIOSEPHOSPHATE
ISOMERASE

(Caenorhabditis
elegans) 		PF00121
(TIM) 		5 VAL A 211
SER A 210
THR A 171
TYR A 207
LEU A 219
 None
SO4  A 901 (-3.7A)
None
None
None
 1.39A 5jh7B-1mo0A:
undetectable		 5jh7B-1mo0A:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tcd TRIOSEPHOSPHATE
ISOMERASE

(Trypanosoma
cruzi) 		PF00121
(TIM) 		5 VAL A 215
SER A 214
THR A 175
TYR A 211
LEU A 223
 None
 1.41A 5jh7B-1tcdA:
undetectable		 5jh7B-1tcdA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tmh TRIOSEPHOSPHATE
ISOMERASE

(Escherichia
coli) 		PF00121
(TIM) 		5 GLN A 184
VAL A 215
SER A 214
THR A 176
TYR A 211
 None
None
SO4  A 555 (-3.4A)
None
None
 1.47A 5jh7B-1tmhA:
undetectable		 5jh7B-1tmhA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tve HOMOSERINE
DEHYDROGENASE

(Saccharomyces
cerevisiae) 		PF00742
(Homoserine_dh)
PF03447
(NAD_binding_3) 		5 VAL A 198
SER A 195
ASP A 196
PRO A 211
LEU A 215
 None
 1.49A 5jh7B-1tveA:
undetectable		 5jh7B-1tveA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u3d CRYPTOCHROME 1
APOPROTEIN

(Arabidopsis
thaliana) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		5 ASN A 137
VAL A 259
SER A 260
ASP A  26
LEU A 250
 None
 1.45A 5jh7B-1u3dA:
undetectable		 5jh7B-1u3dA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wer P120GAP

(Homo sapiens) 		PF00616
(RasGAP) 		5 SER A 817
ASP A 816
GLU A 854
PRO A 912
LEU A 930
 None
 1.37A 5jh7B-1werA:
undetectable		 5jh7B-1werA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xip NUCLEOPORIN NUP159

(Saccharomyces
cerevisiae) 		PF16755
(NUP214) 		5 ASN A  46
VAL A 339
ASP A  43
TYR A 279
PRO A 336
 None
 1.41A 5jh7B-1xipA:
undetectable		 5jh7B-1xipA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yq9 PERIPLASMIC [NIFE]
HYDROGENASE SMALL
SUBUNIT

(Desulfovibrio
gigas) 		PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		5 VAL A  24
SER A  21
THR A  18
GLU A  73
LEU A  35
 None
None
None
SF4  A 267 ( 4.9A)
None
 1.26A 5jh7B-1yq9A:
3.2		 5jh7B-1yq9A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yya TRIOSEPHOSPHATE
ISOMERASE

(Thermus
thermophilus) 		PF00121
(TIM) 		5 VAL A 213
SER A 212
THR A 173
TYR A 209
LEU A 221
 None
PO4  A2004 (-4.0A)
None
None
None
 1.40A 5jh7B-1yyaA:
undetectable		 5jh7B-1yyaA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z3i SIMILAR TO
RAD54-LIKE

(Danio rerio) 		PF00176
(SNF2_N)
PF00271
(Helicase_C) 		5 ASN X 452
VAL X 513
SER X 514
THR X 519
LEU X 582
 None
 1.46A 5jh7B-1z3iX:
undetectable		 5jh7B-1z3iX:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2de0 ALPHA-(1,6)-FUCOSYLT
RANSFERASE

(Homo sapiens) 		PF14604
(SH3_9) 		5 VAL X 262
SER X 263
THR X 265
TYR X 334
LEU X 335
 None
 1.25A 5jh7B-2de0X:
undetectable		 5jh7B-2de0X:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eb0 MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE

(Methanocaldococcus
jannaschii) 		PF01368
(DHH)
PF02833
(DHHA2) 		5 ASN A  36
VAL A 149
SER A 146
ASP A 147
GLU A  38
 None
None
None
MN  A 502 (-2.6A)
None
 1.46A 5jh7B-2eb0A:
undetectable		 5jh7B-2eb0A:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eb0 MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE

(Methanocaldococcus
jannaschii) 		PF01368
(DHH)
PF02833
(DHHA2) 		5 ASN A  36
VAL A 149
SER A 146
THR A  12
GLU A  38
 None
 1.44A 5jh7B-2eb0A:
undetectable		 5jh7B-2eb0A:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fn9 RIBOSE ABC
TRANSPORTER,
PERIPLASMIC
RIBOSE-BINDING
PROTEIN

(Thermotoga
maritima) 		PF13407
(Peripla_BP_4) 		5 SER A  71
ASP A  67
THR A  66
GLU A  46
LEU A  97
 None
 1.30A 5jh7B-2fn9A:
3.9		 5jh7B-2fn9A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gv9 DNA POLYMERASE

(Human
alphaherpesvirus
1) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		5 ASN A 730
VAL A 258
SER A 734
THR A 735
LEU A 636
 None
 1.28A 5jh7B-2gv9A:
undetectable		 5jh7B-2gv9A:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ndh TOLL/INTERLEUKIN-1
RECEPTOR
DOMAIN-CONTAINING
ADAPTER PROTEIN

(Homo sapiens) 		PF13676
(TIR_2) 		5 VAL A 197
TYR A 195
PRO A 177
TYR A 187
LEU A 191
 None
 1.36A 5jh7B-2ndhA:
undetectable		 5jh7B-2ndhA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ohh TYPE A FLAVOPROTEIN
FPRA

(Methanothermobacter
thermautotrophicus) 		PF00258
(Flavodoxin_1)
PF00753
(Lactamase_B) 		5 ASN A  24
SER A 299
THR A  29
TYR A 332
LEU A 333
 None
 1.34A 5jh7B-2ohhA:
4.8		 5jh7B-2ohhA:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ohh TYPE A FLAVOPROTEIN
FPRA

(Methanothermobacter
thermautotrophicus) 		PF00258
(Flavodoxin_1)
PF00753
(Lactamase_B) 		5 ASN A  24
VAL A 302
SER A 299
TYR A 332
LEU A 333
 None
 1.26A 5jh7B-2ohhA:
4.8		 5jh7B-2ohhA:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p9b POSSIBLE PROLIDASE

(Bifidobacterium
longum) 		PF01979
(Amidohydro_1) 		5 SER A 296
THR A 344
GLU A 359
TYR A 449
LEU A 303
 None
 1.47A 5jh7B-2p9bA:
undetectable		 5jh7B-2p9bA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pi5 DNA-DIRECTED RNA
POLYMERASE

(Escherichia
virus T7) 		PF00940
(RNA_pol)
PF14700
(RPOL_N) 		5 GLN A  36
VAL A 429
SER A 430
TYR A 286
LEU A 294
 None
 1.23A 5jh7B-2pi5A:
undetectable		 5jh7B-2pi5A:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pwj MITOCHONDRIAL
PEROXIREDOXIN

(Pisum sativum) 		PF08534
(Redoxin) 		5 GLN A  19
ASN A  38
VAL A 142
ASP A 144
TYR A 141
 None
 1.49A 5jh7B-2pwjA:
undetectable		 5jh7B-2pwjA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qj8 MLR6093 PROTEIN

(Mesorhizobium
japonicum) 		PF04952
(AstE_AspA) 		5 GLN A  75
VAL A 132
ASP A 134
THR A 135
LEU A  11
 None
 1.47A 5jh7B-2qj8A:
4.8		 5jh7B-2qj8A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qk7 GAMMA-HEMOLYSIN
COMPONENT A

(Staphylococcus
aureus) 		PF07968
(Leukocidin) 		5 GLN A  77
ASN A 258
VAL A 154
SER A  81
THR A 228
 None
 1.48A 5jh7B-2qk7A:
undetectable		 5jh7B-2qk7A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rfq 3-HSA HYDROXYLASE,
OXYGENASE

(Rhodococcus
jostii) 		PF02771
(Acyl-CoA_dh_N)
PF08028
(Acyl-CoA_dh_2) 		5 VAL A 104
ASP A 108
THR A 109
PRO A 169
LEU A 167
 None
 1.32A 5jh7B-2rfqA:
undetectable		 5jh7B-2rfqA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v4n MULTIFUNCTIONAL
PROTEIN SUR E

(Salmonella
enterica) 		PF01975
(SurE) 		5 ASN A  96
VAL A  88
SER A  89
THR A 106
LEU A 142
 PO4  A1257 (-3.2A)
None
None
None
None
 1.42A 5jh7B-2v4nA:
undetectable		 5jh7B-2v4nA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xn1 ALPHA-GALACTOSIDASE

(Lactobacillus
acidophilus) 		PF02065
(Melibiase)
PF16874
(Glyco_hydro_36C)
PF16875
(Glyco_hydro_36N) 		5 GLN A 168
VAL A 139
THR A 136
TYR A 108
LEU A 141
 None
None
None
None
GOL  A1736 ( 3.3A)
 1.34A 5jh7B-2xn1A:
undetectable		 5jh7B-2xn1A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyb LACCASE

(Trametes
cinnabarina) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 ASN A 275
SER A 166
ASP A 150
THR A 169
PRO A 160
 None
 1.41A 5jh7B-2xybA:
undetectable		 5jh7B-2xybA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yok EXOGLUCANASE 1

(Trichoderma
harzianum) 		PF00840
(Glyco_hydro_7) 		5 GLN A 199
ASP A 163
TYR A 184
PRO A 190
LEU A 193
 None
 1.22A 5jh7B-2yokA:
undetectable		 5jh7B-2yokA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z67 O-PHOSPHOSERYL-TRNA(
SEC) SELENIUM
TRANSFERASE

(Methanococcus
maripaludis) 		PF05889
(SepSecS) 		5 GLN A 253
ASN A 414
SER A 362
TYR A 257
LEU A 219
 None
 1.50A 5jh7B-2z67A:
undetectable		 5jh7B-2z67A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a71 EXO-ARABINANASE

(Penicillium
chrysogenum) 		no annotation 5 VAL A 371
SER A 370
GLU A 333
PRO A  26
LEU A 344
 None
 1.49A 5jh7B-3a71A:
undetectable		 5jh7B-3a71A:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bin BAND 4.1-LIKE
PROTEIN 3

(Homo sapiens) 		PF00373
(FERM_M)
PF09379
(FERM_N)
PF09380
(FERM_C) 		5 VAL A 186
THR A 154
TYR A 150
PRO A 190
LEU A 205
 None
 1.47A 5jh7B-3binA:
undetectable		 5jh7B-3binA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dev SH1221

(Staphylococcus
haemolyticus) 		PF01368
(DHH)
PF02272
(DHHA1) 		5 GLN A 112
VAL A  81
ASP A  83
TYR A 113
LEU A 101
 None
None
MG  A 323 (-2.7A)
None
None
 1.45A 5jh7B-3devA:
undetectable		 5jh7B-3devA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dul O-METHYLTRANSFERASE,
PUTATIVE

(Bacillus cereus) 		PF01596
(Methyltransf_3) 		6 VAL A  42
SER A  43
ASP A 214
THR A 207
TYR A  71
LEU A  29
 None
 1.28A 5jh7B-3dulA:
undetectable		 5jh7B-3dulA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e2d ALKALINE PHOSPHATASE

(Vibrio sp.
G15-21) 		PF00245
(Alk_phosphatase) 		5 VAL A 109
SER A 110
ASP A 111
THR A 112
LEU A 265
 None
None
None
MG  A 603 ( 4.8A)
None
 1.04A 5jh7B-3e2dA:
2.0		 5jh7B-3e2dA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ei8 LL-DIAMINOPIMELATE
AMINOTRANSFERASE

(Arabidopsis
thaliana) 		PF00155
(Aminotran_1_2) 		5 SER A 238
ASP A 237
GLU A 264
PRO A 363
TYR A 271
 GOL  A 436 (-3.4A)
PLP  A 433 (-3.1A)
GOL  A 436 (-3.3A)
None
GOL  A 436 (-4.6A)
 1.30A 5jh7B-3ei8A:
undetectable		 5jh7B-3ei8A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gr5 ESCC

(Escherichia
coli) 		no annotation 5 VAL A  63
SER A  62
GLU A 105
TYR A  87
LEU A  46
 None
 1.34A 5jh7B-3gr5A:
undetectable		 5jh7B-3gr5A:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h8l NADH OXIDASE

(Acidianus
ambivalens) 		PF07992
(Pyr_redox_2) 		5 VAL A  88
THR A 278
TYR A  90
TYR A 102
LEU A   5
 None
 1.29A 5jh7B-3h8lA:
2.3		 5jh7B-3h8lA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3irz URO-ADHERENCE FACTOR
A

(Staphylococcus
saprophyticus) 		PF17210
(SdrD_B) 		5 GLN A 686
SER A 459
THR A 458
PRO A 651
LEU A 663
 None
 1.43A 5jh7B-3irzA:
undetectable		 5jh7B-3irzA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j1c CHAPERONIN ALPHA
SUBUNIT

(Acidianus
tengchongensis) 		PF00118
(Cpn60_TCP1) 		5 VAL A 146
SER A 147
ASP A 148
PRO A 412
TYR A 200
 None
 1.16A 5jh7B-3j1cA:
undetectable		 5jh7B-3j1cA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m8y PHOSPHOPENTOMUTASE

(Bacillus cereus) 		PF01676
(Metalloenzyme) 		5 VAL A  15
THR A 340
GLU A 342
TYR A 298
LEU A 302
 None
 1.03A 5jh7B-3m8yA:
undetectable		 5jh7B-3m8yA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3on7 OXIDOREDUCTASE,
IRON/ASCORBATE
FAMILY

(Shewanella
oneidensis) 		PF03171
(2OG-FeII_Oxy)
PF14226
(DIOX_N) 		5 ASN A 113
VAL A  91
THR A 149
TYR A  89
PRO A  98
 None
 1.44A 5jh7B-3on7A:
undetectable		 5jh7B-3on7A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opy 6-PHOSPHOFRUCTO-1-KI
NASE GAMMA-SUBUNIT

(Komagataella
pastoris) 		no annotation 5 SER I 109
ASP I 106
GLU I  39
TYR I 122
LEU I 120
 None
 1.24A 5jh7B-3opyI:
undetectable		 5jh7B-3opyI:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pc3 CG1753, ISOFORM A

(Drosophila
melanogaster) 		PF00291
(PALP)
PF00571
(CBS) 		5 VAL A 424
SER A 423
ASP A 418
PRO A 415
LEU A 479
 None
 1.31A 5jh7B-3pc3A:
2.4		 5jh7B-3pc3A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r2t PUTATIVE
UNCHARACTERIZED
PROTEIN

(Staphylococcus
aureus) 		PF02876
(Stap_Strp_tox_C)
PF09199
(SSL_OB) 		5 VAL A 122
ASP A 102
GLU A 162
TYR A  94
LEU A  86
 None
 1.12A 5jh7B-3r2tA:
undetectable		 5jh7B-3r2tA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqo CYSTEINYL-TRNA
SYNTHETASE

(Coxiella
burnetii) 		PF01406
(tRNA-synt_1e)
PF09190
(DALR_2) 		5 ASN A  -1
VAL A   3
SER A   2
TYR A  60
LEU A  55
 None
 1.19A 5jh7B-3tqoA:
undetectable		 5jh7B-3tqoA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vm7 ALPHA-AMYLASE

(Malbranchea
cinnamomea) 		PF00128
(Alpha-amylase)
PF09260
(DUF1966) 		5 ASN A 394
VAL A 449
ASP A 482
TYR A 443
LEU A 466
 None
 1.22A 5jh7B-3vm7A:
undetectable		 5jh7B-3vm7A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wbh ALKALINE PHOSPHATASE

(Halomonas sp.
#593) 		PF00245
(Alk_phosphatase) 		5 VAL A 109
SER A 110
ASP A 111
THR A 112
LEU A 261
 None
None
None
MG  A 501 ( 4.8A)
None
 1.07A 5jh7B-3wbhA:
2.0		 5jh7B-3wbhA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x1b LACCASE

(Lentinus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 ASN A 296
SER A 187
ASP A 171
THR A 190
PRO A 181
 None
 1.40A 5jh7B-3x1bA:
undetectable		 5jh7B-3x1bA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zgb PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Flaveria
pringlei) 		PF00311
(PEPcase) 		5 SER A 535
ASP A 536
GLU A 477
TYR A 581
LEU A 488
 None
 1.36A 5jh7B-3zgbA:
undetectable		 5jh7B-3zgbA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4btp P1

(Pseudomonas
phage phi8) 		no annotation 5 VAL A 510
SER A 509
ASP A 501
TYR A 515
LEU A 567
 None
 1.24A 5jh7B-4btpA:
undetectable		 5jh7B-4btpA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c3h DNA-DIRECTED RNA
POLYMERASE I SUBUNIT
RPA190

(Saccharomyces
cerevisiae) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		5 ASN A 493
VAL A 812
SER A 811
THR A 492
GLU A 491
 None
 1.46A 5jh7B-4c3hA:
undetectable		 5jh7B-4c3hA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c4o CARBONYL REDUCTASE
CPCR2

(Candida
parapsilosis) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 ASN A 290
VAL A  87
SER A 138
TYR A  81
LEU A  34
 None
 1.20A 5jh7B-4c4oA:
undetectable		 5jh7B-4c4oA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c51 CATALASE-PEROXIDASE

(Mycobacterium
tuberculosis) 		PF00141
(peroxidase) 		5 ASN A 493
VAL A 538
SER A 539
THR A 572
LEU A 458
 None
 1.20A 5jh7B-4c51A:
undetectable		 5jh7B-4c51A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cr4 26S PROTEASE
REGULATORY SUBUNIT 8
HOMOLOG

(Saccharomyces
cerevisiae) 		PF00004
(AAA) 		5 GLN J 220
VAL J 213
SER J 214
GLU J 249
LEU J 233
 None
 1.20A 5jh7B-4cr4J:
undetectable		 5jh7B-4cr4J:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dkd INTERLEUKIN-34

(Homo sapiens) 		PF15036
(IL34) 		5 ASN A 155
VAL A 105
SER A 104
ASP A 107
LEU A 165
 None
 1.16A 5jh7B-4dkdA:
undetectable		 5jh7B-4dkdA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gc5 DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL

(Mus musculus) 		PF00398
(RrnaAD) 		5 GLN A  35
VAL A  84
THR A  70
GLU A  61
TYR A 115
 ACT  A 402 (-3.6A)
None
None
None
None
 1.46A 5jh7B-4gc5A:
undetectable		 5jh7B-4gc5A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jgh CULLIN-5

(Homo sapiens) 		PF00888
(Cullin) 		5 GLN D  63
VAL D 135
ASP D 141
THR D 142
LEU D 114
 None
 1.36A 5jh7B-4jghD:
undetectable		 5jh7B-4jghD:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ldp NDP-FOROSAMYLTRANSFE
RASE

(Saccharopolyspora
spinosa) 		PF06722
(DUF1205) 		5 GLN A 347
VAL A 248
THR A 251
PRO A 246
LEU A 391
 None
 1.36A 5jh7B-4ldpA:
4.5		 5jh7B-4ldpA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lw6 BETA-4-GALACTOSYLTRA
NSFERASE 7

(Drosophila
melanogaster) 		PF02709
(Glyco_transf_7C)
PF13733
(Glyco_transf_7N) 		5 GLN A 203
VAL A 274
ASP A 272
TYR A 276
LEU A 298
 None
 1.42A 5jh7B-4lw6A:
undetectable		 5jh7B-4lw6A:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4miv N-SULPHOGLUCOSAMINE
SULPHOHYDROLASE

(Homo sapiens) 		PF00884
(Sulfatase)
PF16347
(DUF4976) 		5 GLN A 239
SER A 272
ASP A 273
GLU A 292
LEU A  50
 None
None
CA  A 601 (-2.3A)
None
None
 1.49A 5jh7B-4mivA:
undetectable		 5jh7B-4mivA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n7t PHOSPHOPENTOMUTASE

(Streptococcus
mutans) 		PF01676
(Metalloenzyme) 		5 VAL A  15
THR A 352
GLU A 354
TYR A 310
LEU A 314
 None
 1.04A 5jh7B-4n7tA:
undetectable		 5jh7B-4n7tA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n9f CULLIN-5

(Homo sapiens) 		no annotation 5 GLN U  63
VAL U 135
ASP U 141
THR U 142
LEU U 114
 None
 1.30A 5jh7B-4n9fU:
undetectable		 5jh7B-4n9fU:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4np6 ADENYLATE KINASE

(Vibrio cholerae) 		PF00406
(ADK)
PF05191
(ADK_lid) 		5 VAL A 106
ASP A 104
TYR A 182
PRO A  87
LEU A   6
 None
 1.05A 5jh7B-4np6A:
3.0		 5jh7B-4np6A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p6y AMINOPEPTIDASE

(Thermotoga
maritima) 		PF05343
(Peptidase_M42) 		5 VAL A 299
SER A 300
ASP A 220
THR A 222
LEU A 261
 None
 1.30A 5jh7B-4p6yA:
undetectable		 5jh7B-4p6yA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qji PHOSPHOPANTOTHENOYLC
YSTEINE
DECARBOXYLASE/PHOSPH
OPANTOTHENATE--CYSTE
INE LIGASE

(Mycolicibacterium
smegmatis) 		PF04127
(DFP) 		5 ASN A 307
VAL A 263
ASP A 261
THR A 257
LEU A 273
 None
 1.50A 5jh7B-4qjiA:
5.2		 5jh7B-4qjiA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v20 CELLOBIOHYDROLASE

(Aspergillus
fumigatus) 		PF00840
(Glyco_hydro_7) 		5 GLN A 186
ASP A 150
TYR A 171
PRO A 177
LEU A 180
 None
 1.23A 5jh7B-4v20A:
undetectable		 5jh7B-4v20A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y96 TRIOSEPHOSPHATE
ISOMERASE

(Gemmata
obscuriglobus) 		PF00121
(TIM) 		5 VAL A 218
SER A 217
THR A 178
TYR A 214
LEU A 226
 None
PO4  A 303 (-3.8A)
None
None
None
 1.34A 5jh7B-4y96A:
undetectable		 5jh7B-4y96A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b5r GASDERMIN-A3

(Mus musculus) 		PF04598
(Gasdermin) 		5 VAL A 120
SER A 119
THR A 117
GLU A 156
LEU A 125
 None
 1.35A 5jh7B-5b5rA:
undetectable		 5jh7B-5b5rA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b8c PEMBROLIZUMAB LIGHT
CHAIN VARIABLE
REGION (PEMVL)
PEMBROLIZUMAB HEAVY
CHAIN VARIABLE
REGION (PEMVH)

(Homo sapiens;
Homo sapiens) 		PF07686
(V-set)
PF07686
(V-set) 		5 ASN B  59
VAL B  37
TYR B  95
PRO A  48
LEU B  45
 None
 1.48A 5jh7B-5b8cB:
undetectable		 5jh7B-5b8cB:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e4r KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans) 		PF01450
(IlvC)
PF07991
(IlvN) 		5 VAL A 398
SER A 399
ASP A 400
THR A 401
PRO A 135
 40E  A 504 ( 3.7A)
40E  A 504 ( 2.5A)
NAP  A 501 ( 4.4A)
None
None
 1.44A 5jh7B-5e4rA:
undetectable		 5jh7B-5e4rA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eyw TRIOSEPHOSPHATE
ISOMERASE

(Litopenaeus
vannamei) 		PF00121
(TIM) 		5 VAL A 213
SER A 212
THR A 173
TYR A 209
LEU A 221
 None
PGA  A 301 (-3.6A)
None
None
None
 1.39A 5jh7B-5eywA:
undetectable		 5jh7B-5eywA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5flw EXO-BETA-1,3-GALACTA
NASE

(Bifidobacterium
bifidum) 		PF04616
(Glyco_hydro_43) 		5 SER A 295
ASP A 296
THR A 297
PRO A 235
LEU A 292
 None
 1.40A 5jh7B-5flwA:
undetectable		 5jh7B-5flwA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5g PUTATIVE XANTHINE
DEHYDROGENASE YAGS
FAD-BINDING SUBUNIT

(Escherichia
coli) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		5 ASN C 210
VAL C 268
SER C 195
THR C 208
LEU C 114
 None
 1.33A 5jh7B-5g5gC:
undetectable		 5jh7B-5g5gC:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzp TRIOSEPHOSPHATE
ISOMERASE

(Plasmodium
falciparum) 		PF00121
(TIM) 		5 VAL A 212
SER A 211
THR A 172
TYR A 208
LEU A 220
 None
PGA  A 301 (-3.6A)
None
None
None
 1.35A 5jh7B-5gzpA:
undetectable		 5jh7B-5gzpA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hy5 TRYPTOPHAN
6-HALOGENASE

(Streptomyces
toxytricini) 		PF04820
(Trp_halogenase) 		5 VAL A 350
SER A 344
PRO A 382
TYR A 394
LEU A 377
 None
 1.35A 5jh7B-5hy5A:
undetectable		 5jh7B-5hy5A:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ic5 CANDIDATE RESPONSE
REGULATOR, CHEY

(Ramlibacter
tataouinensis) 		PF00072
(Response_reg) 		5 VAL A 103
SER A 100
ASP A 101
TYR A 106
LEU A  76
 None
 1.46A 5jh7B-5ic5A:
3.8		 5jh7B-5ic5A:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5u RAGB/SUSD DOMAIN
PROTEIN

(Flavobacterium
johnsoniae) 		PF12771
(SusD-like_2) 		5 GLN A 164
SER A 441
GLU A 438
PRO A 466
LEU A 469
 None
 1.42A 5jh7B-5j5uA:
1.4		 5jh7B-5j5uA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jw7 E3 UBIQUITIN-PROTEIN
LIGASE SOPA
E3 UBIQUITIN-PROTEIN
LIGASE TRIM56

(Salmonella
enterica;
Homo sapiens) 		PF13599
(Pentapeptide_4)
PF13981
(SopA)
PF13445
(zf-RING_UBOX) 		5 VAL A 317
SER A 318
GLU B  58
PRO A 314
LEU A 294
 None
 1.49A 5jh7B-5jw7A:
undetectable		 5jh7B-5jw7A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kel EBOLA SURFACE
GLYCOPROTEIN, GP1

(Zaire
ebolavirus) 		PF01611
(Filo_glycop) 		5 GLN A 251
ASN A 107
ASP A  78
THR A  77
LEU A 256
 None
 1.36A 5jh7B-5kelA:
undetectable		 5jh7B-5kelA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ljo OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA

(Escherichia
coli) 		PF01103
(Bac_surface_Ag)
PF07244
(POTRA) 		5 GLN A 179
VAL A 245
SER A 246
THR A 248
LEU A 219
 None
 1.34A 5jh7B-5ljoA:
undetectable		 5jh7B-5ljoA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lmc ANAEROBIC NITRIC
OXIDE REDUCTASE
FLAVORUBREDOXIN

(Escherichia
coli) 		PF00258
(Flavodoxin_1)
PF00301
(Rubredoxin)
PF00753
(Lactamase_B) 		5 GLN A 170
ASN A  36
ASP A  83
TYR A 194
LEU A 199
 None
None
FEO  A 501 ( 2.5A)
None
None
 1.48A 5jh7B-5lmcA:
5.1		 5jh7B-5lmcA:
21.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5nd4 TUBULIN ALPHA CHAIN

(Bos taurus) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		5 GLN A  11
GLU A 183
PRO A 222
TYR A 224
LEU A 227
 GTP  A 500 ( 3.1A)
GTP  A 500 (-3.3A)
None
GTP  A 500 (-3.2A)
GTP  A 500 ( 4.1A)
 0.77A 5jh7B-5nd4A:
51.3		 5jh7B-5nd4A:
38.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o5d GLUCANASE

(Trichoderma
atroviride) 		no annotation 5 GLN A 186
ASP A 150
TYR A 171
PRO A 177
LEU A 180
 None
 1.20A 5jh7B-5o5dA:
undetectable		 5jh7B-5o5dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5of4 TFIIH BASAL
TRANSCRIPTION FACTOR
COMPLEX HELICASE XPD
SUBUNIT

(Homo sapiens) 		PF06733
(DEAD_2)
PF06777
(HBB)
PF13307
(Helicase_C_2) 		5 VAL B  83
THR B  76
GLU B  79
TYR B  72
LEU B  53
 None
 1.39A 5jh7B-5of4B:
undetectable		 5jh7B-5of4B:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u9z PHOSPHOGLYCEROL
TRANSFERASE

(Streptococcus
pyogenes) 		no annotation 5 SER A 491
ASP A 733
THR A 732
TYR A 679
LEU A 676
 None
 1.30A 5jh7B-5u9zA:
2.0		 5jh7B-5u9zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5upr TRIOSEPHOSPHATE
ISOMERASE

(Toxoplasma
gondii) 		PF00121
(TIM) 		5 VAL A 336
SER A 335
THR A 296
TYR A 332
LEU A 344
 None
SO4  A 401 (-3.7A)
None
None
None
 1.47A 5jh7B-5uprA:
undetectable		 5jh7B-5uprA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ur2 BIFUNCTIONAL PROTEIN
PUTA

(Bdellovibrio
bacteriovorus) 		PF00171
(Aldedh)
PF01619
(Pro_dh) 		5 VAL A 195
SER A 194
ASP A 141
THR A 139
LEU A 220
 None
 1.35A 5jh7B-5ur2A:
2.4		 5jh7B-5ur2A:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uto EDD DOMAIN PROTEIN,
DEGV FAMILY

(Staphylococcus
aureus) 		no annotation 5 VAL A 222
ASP A 224
TYR A 280
TYR A 256
LEU A 230
 None
 1.40A 5jh7B-5utoA:
2.2		 5jh7B-5utoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wiv D(4) DOPAMINE
RECEPTOR, SOLUBLE
CYTOCHROME B562
CHIMERA

(Escherichia
coli;
Homo sapiens) 		no annotation 5 ASN A 125
VAL A 166
SER A 163
THR A 159
PRO A 169
 None
OLA  A1209 ( 4.9A)
None
None
None
 1.22A 5jh7B-5wivA:
undetectable		 5jh7B-5wivA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x5y PROBABLE ATP-BINDING
COMPONENT OF ABC
TRANSPORTER

(Pseudomonas
aeruginosa) 		no annotation 5 VAL B 197
ASP B 194
THR B 193
TYR B 234
LEU B 235
 None
 1.11A 5jh7B-5x5yB:
undetectable		 5jh7B-5x5yB:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yd5 SCFV 4B08

(Mus musculus) 		no annotation 5 GLN A 235
VAL A  39
TYR A  97
PRO A 189
LEU A  47
 None
 1.46A 5jh7B-5yd5A:
undetectable		 5jh7B-5yd5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ze8 CYTOCHROME C552

(Thermochromatium
tepidum) 		no annotation 5 VAL A  40
SER A  41
GLU A 123
PRO A 208
LEU A 210
 None
None
None
None
HEM  A 501 (-4.6A)
 1.19A 5jh7B-5ze8A:
undetectable		 5jh7B-5ze8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cnk IGG1 KAPPA LIGHT
CHAIN
IGG1 HEAVY CHAIN

(Mus musculus;
Mus musculus) 		no annotation
no annotation 		5 ASN G  60
VAL G  38
TYR G  96
PRO F  49
LEU G  46
 None
 1.34A 5jh7B-6cnkG:
undetectable		 5jh7B-6cnkG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cpy GRMZM2G135359
PSEUDOKINASE

(Zea mays) 		no annotation 5 VAL A 362
SER A 359
ASP A 358
GLU A 411
LEU A 364
 None
 1.41A 5jh7B-6cpyA:
undetectable		 5jh7B-6cpyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ek2 SINGLE CHAIN FV
FRAGMENT

(Mus musculus) 		no annotation 5 VAL H 206
THR H 219
TYR H 264
PRO H 382
LEU H 214
 None
 1.41A 5jh7B-6ek2H:
undetectable		 5jh7B-6ek2H:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6flx ABC TRANSPORTER
SYSTEM, ATP-BINDING
PROTEIN

(Burkholderia
pseudomallei) 		no annotation 5 VAL A 230
ASP A 227
THR A 226
TYR A 267
LEU A 268
 None
 1.14A 5jh7B-6flxA:
undetectable		 5jh7B-6flxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1air PECTATE LYASE C

(Dickeya
chrysanthemi) 		PF00544
(Pec_lyase_C) 		4 VAL A 135
ASN A 210
ILE A 185
VAL A 169
 None
 1.19A 5jh7C-1airA:
undetectable		 5jh7C-1airA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bsl BACTERIAL LUCIFERASE

(Vibrio harveyi) 		PF00296
(Bac_luciferase) 		4 GLU A  89
ASN A   9
ILE A  21
VAL A  58
 None
 0.96A 5jh7C-1bslA:
undetectable		 5jh7C-1bslA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h5q NADP-DEPENDENT
MANNITOL
DEHYDROGENASE

(Agaricus
bisporus) 		PF13561
(adh_short_C2) 		4 VAL A  55
GLU A  58
ASN A  96
ILE A  94
 None
None
NAP  A 263 (-3.5A)
None
 0.94A 5jh7C-1h5qA:
6.6		 5jh7C-1h5qA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hww ALPHA-MANNOSIDASE II

(Drosophila
melanogaster) 		PF01074
(Glyco_hydro_38)
PF07748
(Glyco_hydro_38C)
PF09261
(Alpha-mann_mid) 		4 LEU A 494
VAL A 436
GLU A 440
ILE A 474
 None
 1.20A 5jh7C-1hwwA:
undetectable		 5jh7C-1hwwA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1itu RENAL DIPEPTIDASE

(Homo sapiens) 		PF01244
(Peptidase_M19) 		4 LEU A 196
VAL A 201
ILE A 274
VAL A 232
 None
 1.11A 5jh7C-1ituA:
undetectable		 5jh7C-1ituA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j2z ACYL-[ACYL-CARRIER-P
ROTEIN]--UDP-N-ACETY
LGLUCOSAMINE
O-ACYLTRANSFERASE

(Helicobacter
pylori) 		PF00132
(Hexapep)
PF13720
(Acetyltransf_11) 		4 LEU A  64
GLU A  79
ILE A  16
VAL A  32
 None
 0.92A 5jh7C-1j2zA:
undetectable		 5jh7C-1j2zA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ksi COPPER AMINE OXIDASE

(Pisum sativum) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3) 		4 LEU A 622
GLU A 505
ILE A 593
VAL A 508
 None
 1.16A 5jh7C-1ksiA:
undetectable		 5jh7C-1ksiA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mqq ALPHA-D-GLUCURONIDAS
E

(Geobacillus
stearothermophilus) 		PF03648
(Glyco_hydro_67N)
PF07477
(Glyco_hydro_67C)
PF07488
(Glyco_hydro_67M) 		4 LEU A 314
VAL A 279
ASN A 193
ILE A 230
 None
 0.81A 5jh7C-1mqqA:
undetectable		 5jh7C-1mqqA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nvm ACETALDEHYDE
DEHYDROGENASE
(ACYLATING)

(Pseudomonas sp.
CF600) 		PF01118
(Semialdhyde_dh)
PF09290
(AcetDehyd-dimer) 		4 VAL B  60
GLU B  61
ASN B 126
ILE B 108
 None
MPD  B3528 (-3.4A)
None
None
 1.03A 5jh7C-1nvmB:
2.9		 5jh7C-1nvmB:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o4u TYPE II QUINOLIC
ACID
PHOSPHORIBOSYLTRANSF
ERASE

(Thermotoga
maritima) 		PF01729
(QRPTase_C)
PF02749
(QRPTase_N) 		4 LEU A  94
GLU A  55
ILE A 136
VAL A  49
 None
 1.15A 5jh7C-1o4uA:
undetectable		 5jh7C-1o4uA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pg6 HYPOTHETICAL PROTEIN
SPYM3_0169

(Streptococcus
pyogenes) 		PF01987
(AIM24) 		4 LEU A 108
VAL A 142
GLU A 125
ILE A 171
 None
 1.13A 5jh7C-1pg6A:
undetectable		 5jh7C-1pg6A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rie RIESKE IRON-SULFUR
PROTEIN

(Bos taurus) 		PF00355
(Rieske) 		4 LEU A 180
VAL A 182
ASN A  86
VAL A 133
 None
 1.11A 5jh7C-1rieA:
undetectable		 5jh7C-1rieA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rqg METHIONYL-TRNA
SYNTHETASE

(Pyrococcus
abyssi) 		PF08264
(Anticodon_1)
PF09334
(tRNA-synt_1g) 		4 LEU A 199
ILE A 300
LYS A 213
VAL A 216
 None
 1.03A 5jh7C-1rqgA:
undetectable		 5jh7C-1rqgA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tlk TELOKIN

(Meleagris
gallopavo) 		PF07679
(I-set) 		4 VAL A 118
GLU A 123
ILE A  90
VAL A  73
 None
 1.19A 5jh7C-1tlkA:
undetectable		 5jh7C-1tlkA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uar RHODANESE

(Thermus
thermophilus) 		PF00581
(Rhodanese) 		4 LEU A 110
VAL A   8
GLU A   7
VAL A 108
 None
 1.15A 5jh7C-1uarA:
undetectable		 5jh7C-1uarA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vl8 GLUCONATE
5-DEHYDROGENASE

(Thermotoga
maritima) 		PF13561
(adh_short_C2) 		4 LEU A  77
GLU A  72
ASN A  93
VAL A  68
 None
None
None
NAP  A 274 (-3.6A)
 1.04A 5jh7C-1vl8A:
6.5		 5jh7C-1vl8A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wue MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN

(Enterococcus
faecalis) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LEU A1075
VAL A1087
GLU A1105
ILE A1366
 None
 1.13A 5jh7C-1wueA:
3.2		 5jh7C-1wueA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xkt FATTY ACID SYNTHASE

(Homo sapiens) 		PF00975
(Thioesterase) 		4 LEU A2416
VAL A2397
GLU A2394
ILE A2250
 None
 1.12A 5jh7C-1xktA:
3.8		 5jh7C-1xktA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y5e MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
B

(Bacillus cereus) 		PF00994
(MoCF_biosynth) 		4 LEU A  77
VAL A  19
GLU A  51
ILE A  91
 None
 0.98A 5jh7C-1y5eA:
undetectable		 5jh7C-1y5eA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z82 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE

(Thermotoga
maritima) 		PF01210
(NAD_Gly3P_dh_N)
PF07479
(NAD_Gly3P_dh_C) 		4 VAL A 170
GLU A 173
ASN A 284
ILE A 286
 None
 1.17A 5jh7C-1z82A:
undetectable		 5jh7C-1z82A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c8j FERROCHELATASE 1

(Bacillus
anthracis) 		PF00762
(Ferrochelatase) 		4 VAL A  77
GLU A  76
ILE A 143
LYS A 307
 None
 1.15A 5jh7C-2c8jA:
3.5		 5jh7C-2c8jA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gmh ELECTRON TRANSFER
FLAVOPROTEIN-UBIQUIN
ONE OXIDOREDUCTASE

(Sus scrofa) 		PF05187
(ETF_QO)
PF13450
(NAD_binding_8) 		4 LEU A 294
GLU A 306
ILE A 364
VAL A 291
 None
None
UQ5  A 612 ( 4.8A)
UQ5  A 612 ( 4.9A)
 1.21A 5jh7C-2gmhA:
undetectable		 5jh7C-2gmhA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gq3 MALATE SYNTHASE G

(Mycobacterium
tuberculosis) 		PF01274
(Malate_synthase) 		4 LEU A 370
VAL A 419
ILE A 350
VAL A  39
 None
 1.19A 5jh7C-2gq3A:
undetectable		 5jh7C-2gq3A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i6l MITOGEN-ACTIVATED
PROTEIN KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  72
VAL A  78
ILE A  83
VAL A  80
 None
 1.07A 5jh7C-2i6lA:
undetectable		 5jh7C-2i6lA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jfe CYTOSOLIC
BETA-GLUCOSIDASE

(Homo sapiens) 		PF00232
(Glyco_hydro_1) 		4 GLU X 230
ASN X 374
ILE X 371
VAL X 353
 None
 1.16A 5jh7C-2jfeX:
2.6		 5jh7C-2jfeX:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lv5 UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		PF10052
(DUF2288) 		4 LEU A  37
VAL A  48
GLU A  47
VAL A  60
 None
 1.20A 5jh7C-2lv5A:
undetectable		 5jh7C-2lv5A:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m9v TELOMERE REPLICATION
PROTEIN EST3

(Saccharomyces
cerevisiae) 		PF10341
(TPP1) 		4 LEU A  45
GLU A  98
ILE A  84
VAL A 157
 None
 1.15A 5jh7C-2m9vA:
undetectable		 5jh7C-2m9vA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mbg RALA-BINDING PROTEIN
1

(Homo sapiens) 		PF00620
(RhoGAP) 		4 LEU A 373
GLU A 215
ILE A 230
VAL A 220
 None
 0.92A 5jh7C-2mbgA:
undetectable		 5jh7C-2mbgA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nz9 BOTULINUM NEUROTOXIN
TYPE A

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N) 		4 LEU A 853
GLU A 868
ASN A 722
ILE A 725
 None
 1.13A 5jh7C-2nz9A:
undetectable		 5jh7C-2nz9A:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pw6 UNCHARACTERIZED
PROTEIN YGID

(Escherichia
coli) 		PF02900
(LigB) 		4 LEU A 238
GLU A 233
ASN A 198
ILE A 258
 None
ZN  A 274 ( 4.6A)
None
None
 1.10A 5jh7C-2pw6A:
undetectable		 5jh7C-2pw6A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2va1 URIDYLATE KINASE

(Ureaplasma
parvum) 		PF00696
(AA_kinase) 		4 LEU A  31
GLU A  85
ASN A  52
ILE A  22
 None
 0.96A 5jh7C-2va1A:
undetectable		 5jh7C-2va1A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		4 LEU A1061
GLU A1088
ASN A1017
ILE A 984
 None
 1.17A 5jh7C-2vdcA:
2.3		 5jh7C-2vdcA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w2d BOTULINUM NEUROTOXIN
A HEAVY CHAIN

(Clostridium
botulinum) 		PF07952
(Toxin_trans) 		4 LEU B 853
GLU B 868
ASN B 722
ILE B 725
 None
 1.20A 5jh7C-2w2dB:
undetectable		 5jh7C-2w2dB:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w3p BENZOYL-COA-DIHYDROD
IOL LYASE

(Paraburkholderia
xenovorans) 		PF00378
(ECH_1) 		4 LEU A 318
GLU A 324
ILE A  44
VAL A  11
 None
 1.10A 5jh7C-2w3pA:
undetectable		 5jh7C-2w3pA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ygk NURA

(Sulfolobus
solfataricus) 		PF09376
(NurA) 		4 LEU A 131
VAL A  79
GLU A  77
ILE A 295
 None
 1.19A 5jh7C-2ygkA:
undetectable		 5jh7C-2ygkA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z7x TOLL-LIKE RECEPTOR
1, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Homo sapiens) 		PF11921
(DUF3439)
PF13855
(LRR_8) 		4 LEU B 428
GLU B 472
ASN B 455
ILE B 457
 None
 1.03A 5jh7C-2z7xB:
undetectable		 5jh7C-2z7xB:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dh4 SODIUM/GLUCOSE
COTRANSPORTER

(Vibrio
parahaemolyticus) 		PF00474
(SSF) 		4 VAL A 302
ASN A  64
ILE A  61
VAL A 297
 None
GAL  A 701 (-3.9A)
None
None
 1.00A 5jh7C-3dh4A:
undetectable		 5jh7C-3dh4A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gdb PUTATIVE
UNCHARACTERIZED
PROTEIN SPR0440

(Streptococcus
pneumoniae) 		PF03644
(Glyco_hydro_85) 		4 LEU A 562
GLU A 579
ILE A 476
LYS A 488
 None
 1.14A 5jh7C-3gdbA:
2.1		 5jh7C-3gdbA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hka URONATE ISOMERASE

(Bacillus
halodurans) 		no annotation 4 VAL A  22
ASN A 329
ILE A 334
LYS A 370
 None
 0.95A 5jh7C-3hkaA:
undetectable		 5jh7C-3hkaA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j1c CHAPERONIN ALPHA
SUBUNIT

(Acidianus
tengchongensis) 		PF00118
(Cpn60_TCP1) 		4 LEU A 283
ILE A 317
LYS A 289
VAL A 287
 None
 1.14A 5jh7C-3j1cA:
undetectable		 5jh7C-3j1cA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR CWF11

(Schizosaccharomyces
pombe) 		PF13087
(AAA_12)
PF16399
(Aquarius_N) 		4 VAL X 407
GLU X 404
ILE X 226
LYS X 269
 None
 0.91A 5jh7C-3jb9X:
undetectable		 5jh7C-3jb9X:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ky9 PROTO-ONCOGENE VAV

(Homo sapiens) 		PF00130
(C1_1)
PF00169
(PH)
PF00621
(RhoGEF)
PF11971
(CAMSAP_CH) 		4 LEU A 472
VAL A 454
GLU A 500
ILE A 433
 None
 0.86A 5jh7C-3ky9A:
undetectable		 5jh7C-3ky9A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oml PEROXISOMAL
MULTIFUNCTIONAL
ENZYME TYPE 2,
CG3415

(Drosophila
melanogaster) 		PF00106
(adh_short)
PF01575
(MaoC_dehydratas)
PF13452
(MaoC_dehydrat_N) 		4 VAL A 196
GLU A 241
ASN A 179
VAL A 194
 None
 1.14A 5jh7C-3omlA:
5.1		 5jh7C-3omlA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pu6 UNCHARACTERIZED
PROTEIN

(Wolinella
succinogenes) 		no annotation 4 LEU A   6
VAL A  35
GLU A  27
ILE A 110
 None
 0.71A 5jh7C-3pu6A:
4.2		 5jh7C-3pu6A:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qvm OLEI00960

(Oleispira
antarctica) 		PF00561
(Abhydrolase_1) 		4 LEU A  31
VAL A  56
GLU A  51
ILE A 128
 None
 0.81A 5jh7C-3qvmA:
undetectable		 5jh7C-3qvmA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r4r HYPOTHETICAL
FIMBRIAL ASSEMBLY
PROTEIN

(Parabacteroides
distasonis) 		PF06321
(P_gingi_FimA) 		4 LEU A 187
GLU A  63
ILE A 154
VAL A 165
 None
None
EDO  A 325 ( 4.4A)
None
 1.09A 5jh7C-3r4rA:
undetectable		 5jh7C-3r4rA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3see HYPOTHETICAL SUGAR
BINDING PROTEIN

(Bacteroides
thetaiotaomicron) 		PF15425
(DUF4627) 		4 LEU A 107
ILE A 164
LYS A 172
VAL A 173
 None
 1.14A 5jh7C-3seeA:
undetectable		 5jh7C-3seeA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sn0 PUTATIVE
L-ALANINE-DL-GLUTAMA
TE EPIMERASE

(Paraburkholderia
xenovorans) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LEU A 109
VAL A 334
ASN A  91
ILE A 292
 None
 1.16A 5jh7C-3sn0A:
undetectable		 5jh7C-3sn0A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tzq SHORT-CHAIN TYPE
DEHYDROGENASE/REDUCT
ASE

(Mycobacterium
marinum) 		no annotation 4 VAL B  68
GLU B  65
ASN B 139
ILE B 162
 None
 1.06A 5jh7C-3tzqB:
6.9		 5jh7C-3tzqB:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vjj P9-1

(Rice black
streaked dwarf
virus) 		PF06043
(Reo_P9) 		4 LEU A 191
VAL A 176
GLU A 187
VAL A 172
 None
 1.20A 5jh7C-3vjjA:
undetectable		 5jh7C-3vjjA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wiq KOJIBIOSE
PHOSPHORYLASE

(Caldicellulosiruptor
saccharolyticus) 		PF03632
(Glyco_hydro_65m)
PF03633
(Glyco_hydro_65C)
PF03636
(Glyco_hydro_65N) 		4 LEU A  74
VAL A  41
GLU A  45
ILE A 200
 None
 1.17A 5jh7C-3wiqA:
undetectable		 5jh7C-3wiqA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zef PRE-MRNA-SPLICING
FACTOR 8

(Saccharomyces
cerevisiae) 		PF08084
(PROCT)
PF10596
(U6-snRNA_bdg)
PF10597
(U5_2-snRNA_bdg)
PF10598
(RRM_4)
PF12134
(PRP8_domainIV) 		4 LEU B1302
VAL B1304
GLU B1308
ILE B1444
 None
 1.13A 5jh7C-3zefB:
undetectable		 5jh7C-3zefB:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a7w URIDYLATE KINASE

(Helicobacter
pylori) 		PF00696
(AA_kinase) 		4 LEU A 183
ILE A 204
LYS A 240
VAL A 239
 None
 1.05A 5jh7C-4a7wA:
undetectable		 5jh7C-4a7wA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4are COLLAGENASE G

(Hathewaya
histolytica) 		PF01752
(Peptidase_M9)
PF08453
(Peptidase_M9_N) 		4 VAL A 378
GLU A 381
ASN A 287
ILE A 290
 None
None
P6G  A1791 ( 4.3A)
None
 1.19A 5jh7C-4areA:
undetectable		 5jh7C-4areA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dbe OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE

(Sulfolobus
solfataricus) 		PF00215
(OMPdecase) 		4 LEU A   8
GLU A  55
ASN A 204
ILE A 207
 None
 1.19A 5jh7C-4dbeA:
undetectable		 5jh7C-4dbeA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ei0 UNCHARACTERIZED
HYPOTHETICAL PROTEIN

(Parabacteroides
merdae) 		PF14725
(DUF4466) 		4 LEU A 266
GLU A 297
ILE A 198
VAL A 326
 None
 1.03A 5jh7C-4ei0A:
undetectable		 5jh7C-4ei0A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gl9 TYROSINE-PROTEIN
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		4 VAL A 879
GLU A 877
ILE A 899
LYS A 914
 None
 1.19A 5jh7C-4gl9A:
undetectable		 5jh7C-4gl9A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h1g MALTOSE BINDING
PROTEIN-CAKAR3 MOTOR
DOMAIN FUSION
PROTEIN

(Escherichia
coli;
Candida
albicans) 		PF00225
(Kinesin)
PF13416
(SBP_bac_8) 		4 GLU A 422
ASN A 626
ILE A 622
VAL A 350
 None
 0.96A 5jh7C-4h1gA:
undetectable		 5jh7C-4h1gA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igd MANNAN-BINDING
LECTIN SERINE
PROTEASE 1

(Homo sapiens) 		PF00084
(Sushi)
PF00089
(Trypsin) 		4 LEU A 479
GLU A 557
ILE A 684
VAL A 486
 None
 1.20A 5jh7C-4igdA:
undetectable		 5jh7C-4igdA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jkm BETA-GLUCURONIDASE

(Clostridium
perfringens) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N) 		4 LEU A 103
GLU A  31
ILE A 171
VAL A 130
 None
 0.80A 5jh7C-4jkmA:
undetectable		 5jh7C-4jkmA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k28 SHIKIMATE
DEHYDROGENASE FAMILY
PROTEIN

(Pseudomonas
putida) 		PF00899
(ThiF)
PF08501
(Shikimate_dh_N) 		4 LEU A 233
GLU A 229
ILE A 140
VAL A 224
 None
None
None
NAD  A 301 (-4.0A)
 1.10A 5jh7C-4k28A:
2.0		 5jh7C-4k28A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m1n UBIQUITIN
CONJUGATING ENZYME
UBC9

(Plasmodium
falciparum) 		PF00179
(UQ_con) 		4 LEU A  81
GLU A 132
LYS A 147
VAL A 148
 None
 1.14A 5jh7C-4m1nA:
undetectable		 5jh7C-4m1nA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mzd NISIN LEADER
PEPTIDE-PROCESSING
SERINE PROTEASE NISP

(Lactococcus
lactis) 		PF00082
(Peptidase_S8) 		4 LEU A 410
ILE A 428
LYS A 433
VAL A 434
 None
 1.08A 5jh7C-4mzdA:
2.0		 5jh7C-4mzdA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4odj S-ADENOSYLMETHIONINE
SYNTHASE

(Cryptosporidium
hominis) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		4 LEU A 231
VAL A 234
GLU A 168
ILE A 221
 None
 1.20A 5jh7C-4odjA:
undetectable		 5jh7C-4odjA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4psn SSDNA BINDING
PROTEIN

(Aeropyrum
pernix) 		PF10015
(DUF2258) 		4 LEU A 148
VAL A 210
ILE A 119
VAL A 163
 None
 0.70A 5jh7C-4psnA:
undetectable		 5jh7C-4psnA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q6x PHOSPHOLIPASE D
STSICTOX-BETAIC1

(Sicarius
terrosus) 		no annotation 4 LEU A 131
VAL A  89
GLU A  31
ILE A 175
 None
None
MG  A 301 (-2.6A)
None
 1.13A 5jh7C-4q6xA:
undetectable		 5jh7C-4q6xA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r6g LEUCINE RICH REPEATS
DLRR_K

(synthetic
construct) 		PF12799
(LRR_4)
PF13516
(LRR_6)
PF13855
(LRR_8) 		4 LEU A 110
GLU A 105
ILE A  58
LYS A  81
 None
 1.08A 5jh7C-4r6gA:
undetectable		 5jh7C-4r6gA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ra6 L-ASPARAGINASE

(Pyrococcus
furiosus) 		PF00710
(Asparaginase) 		4 LEU A 148
GLU A 164
LYS A 145
VAL A 146
 None
 0.80A 5jh7C-4ra6A:
undetectable		 5jh7C-4ra6A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4um2 TELOMERASE-BINDING
PROTEIN EST1A

(Homo sapiens) 		PF10373
(EST1_DNA_bind)
PF10374
(EST1) 		4 LEU A 920
VAL A 915
ASN A 946
ILE A 945
 None
 1.07A 5jh7C-4um2A:
undetectable		 5jh7C-4um2A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xfw ALPHA-CARBONIC
ANHYDRASE

(Helicobacter
pylori) 		PF00194
(Carb_anhydrase) 		4 LEU A 142
VAL A 131
ILE A 158
VAL A 109
 None
 0.93A 5jh7C-4xfwA:
undetectable		 5jh7C-4xfwA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ztd PROLIFERATING CELL
NUCLEAR ANTIGEN

(Homo sapiens) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		4 LEU A 227
VAL A 136
GLU A 198
ILE A 128
 None
 1.11A 5jh7C-4ztdA:
undetectable		 5jh7C-4ztdA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cx8 LIPOPROTEIN RAGB

(Porphyromonas
gingivalis) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 LEU A 408
GLU A 390
ILE A 288
VAL A 384
 None
 1.08A 5jh7C-5cx8A:
undetectable		 5jh7C-5cx8A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5czz CRISPR-ASSOCIATED
ENDONUCLEASE CAS9

(Staphylococcus
aureus) 		PF13395
(HNH_4)
PF16592
(Cas9_REC) 		4 LEU A  35
GLU A  38
ASN A 995
ILE A 982
 None
 0.83A 5jh7C-5czzA:
undetectable		 5jh7C-5czzA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5epo 7-ALPHA-HYDROXYSTERO
ID DEYDROGENASE

(Clostridium
sardiniense) 		PF13561
(adh_short_C2) 		4 VAL A  77
GLU A  81
ASN A  89
ILE A 140
 None
 1.10A 5jh7C-5epoA:
6.1		 5jh7C-5epoA:
19.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5flz TUBULIN GAMMA CHAIN

(Saccharomyces
cerevisiae) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		4 LEU C 412
VAL C 419
GLU C 422
ASN C 153
 None
 1.18A 5jh7C-5flzC:
42.5		 5jh7C-5flzC:
31.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fmq INFLUENZA A PB2
SUBUNIT

(Influenza A
virus) 		PF00604
(Flu_PB2) 		4 VAL A 485
GLU A 487
ILE A 398
VAL A 386
 None
 1.17A 5jh7C-5fmqA:
undetectable		 5jh7C-5fmqA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gve DNA TOPOISOMERASE
3-BETA-1

(Homo sapiens) 		PF01131
(Topoisom_bac)
PF01751
(Toprim) 		4 VAL A  61
GLU A  91
ILE A 112
VAL A 129
 None
 0.74A 5jh7C-5gveA:
undetectable		 5jh7C-5gveA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j1l TOXR-ACTIVATED GENE
(TAGE)

(Helicobacter
pylori) 		PF01551
(Peptidase_M23) 		4 LEU A 174
GLU A 146
ILE A 205
VAL A 182
 None
 1.18A 5jh7C-5j1lA:
undetectable		 5jh7C-5j1lA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jfq GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE

(Geoglobus
acetivorans) 		PF00348
(polyprenyl_synt) 		4 LEU A 120
GLU A 115
ILE A 144
VAL A  73
 None
 1.18A 5jh7C-5jfqA:
undetectable		 5jh7C-5jfqA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mc9 LAMININ SUBUNIT
ALPHA-1

(Mus musculus) 		PF00054
(Laminin_G_1)
PF06009
(Laminin_II) 		4 LEU A2382
ILE A2398
LYS A2372
VAL A2373
 None
 1.18A 5jh7C-5mc9A:
undetectable		 5jh7C-5mc9A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mh5 D-2-HYDROXYACID
DEHYDROGENASE

(Haloferax
mediterranei) 		no annotation 4 LEU A 235
GLU A 204
ILE A 187
VAL A 207
 None
 1.16A 5jh7C-5mh5A:
undetectable		 5jh7C-5mh5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5moy BOTULINUM NEUROTOXIN
TYPE A

(Clostridium
botulinum) 		PF07951
(Toxin_R_bind_C)
PF07953
(Toxin_R_bind_N) 		4 GLU A 982
ASN A1021
ILE A1041
VAL A 997
 None
 1.04A 5jh7C-5moyA:
undetectable		 5jh7C-5moyA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ms7 LEGIONELLA
PNEUMOPHILA EFFECTOR
PROTEIN RAVZ

(Legionella
pneumophila) 		no annotation 4 VAL A  59
GLU A 302
ASN A 248
ILE A 281
 None
 0.93A 5jh7C-5ms7A:
undetectable		 5jh7C-5ms7A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n6y NITROGENASE
VANADIUM-IRON
PROTEIN BETA CHAIN

(Azotobacter
vinelandii) 		no annotation 4 LEU E 355
VAL E 353
ILE E 454
VAL E 329
 None
 1.18A 5jh7C-5n6yE:
undetectable		 5jh7C-5n6yE:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ncr TYROSINE PHOSPHATASE

(Orf virus) 		PF00782
(DSPc) 		4 LEU A  37
VAL A  35
GLU A 102
ILE A  77
 None
 1.10A 5jh7C-5ncrA:
undetectable		 5jh7C-5ncrA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o9i TRANSCRIPTION
INITIATION FACTOR
IIB,TRANSCRIPTION
INITIATION FACTOR
IIB

(Methanocaldococcus
vulcanius) 		no annotation 4 VAL A  49
GLU A  12
ILE A 180
VAL A  51
 None
 0.88A 5jh7C-5o9iA:
undetectable		 5jh7C-5o9iA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oas MALATE SYNTHASE G

(Pseudomonas
aeruginosa) 		no annotation 4 LEU A  92
GLU A  96
ILE A 429
LYS A 445
 None
 1.05A 5jh7C-5oasA:
undetectable		 5jh7C-5oasA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ur0 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Naegleria
gruberi) 		no annotation 4 LEU A 154
ILE A 255
LYS A 307
VAL A 308
 None
 1.02A 5jh7C-5ur0A:
3.0		 5jh7C-5ur0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wc2 PACHYTENE CHECKPOINT
PROTEIN 2 HOMOLOG

(Homo sapiens) 		no annotation 4 LEU A 296
VAL A 174
ILE A 240
LYS A 288
 None
 1.09A 5jh7C-5wc2A:
undetectable		 5jh7C-5wc2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wq7 PUTATIVE TYPE II
SECRETION SYSTEM
PROTEIN D

(Escherichia
coli) 		PF00263
(Secretin)
PF03958
(Secretin_N) 		4 LEU A 109
VAL A 141
GLU A 137
VAL A 107
 None
 1.18A 5jh7C-5wq7A:
undetectable		 5jh7C-5wq7A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wsk RIBULOSE
BISPHOSPHATE
CARBOXYLASE SMALL
CHAIN

(Triticum
aestivum) 		no annotation 4 VAL E 133
GLU E 134
ILE E  81
VAL E 129
 None
 1.09A 5jh7C-5wskE:
undetectable		 5jh7C-5wskE:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wt3 TRNA
(GUANINE(37)-N1)-MET
HYLTRANSFERASE TRM5A

(Pyrococcus
abyssi) 		no annotation 4 LEU A 228
VAL A 155
GLU A 152
ILE A 239
 None
 1.07A 5jh7C-5wt3A:
undetectable		 5jh7C-5wt3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wy0 SMALL RNA
2'-O-METHYLTRANSFERA
SE

(Homo sapiens) 		no annotation 4 LEU A  92
VAL A 119
ILE A  49
VAL A  85
 None
None
SAM  A 800 (-4.0A)
SAM  A 800 (-3.5A)
 1.15A 5jh7C-5wy0A:
undetectable		 5jh7C-5wy0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3j TOLL-LIKE RECEPTOR 9

(Equus caballus) 		no annotation 4 LEU A 682
GLU A 729
ASN A 711
ILE A 713
 None
 0.99A 5jh7C-5y3jA:
undetectable		 5jh7C-5y3jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zln TOLL-LIKE RECEPTOR 9

(Mus musculus) 		no annotation 4 LEU A 683
GLU A 730
ASN A 712
ILE A 714
 None
 1.02A 5jh7C-5zlnA:
undetectable		 5jh7C-5zlnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6axe MALATE SYNTHASE G

(Mycobacterium
marinum) 		PF01274
(Malate_synthase) 		4 LEU A 374
VAL A 423
ILE A 350
VAL A  39
 None
 1.17A 5jh7C-6axeA:
undetectable		 5jh7C-6axeA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6btg FUCULOSE PHOSPHATE
ALDOLASE

(Bacillus
thuringiensis) 		no annotation 4 LEU A 159
GLU A  76
ILE A 166
VAL A  94
 None
13P  A 302 ( 3.6A)
None
None
 1.15A 5jh7C-6btgA:
undetectable		 5jh7C-6btgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bxa TOLL-LIKE RECEPTOR
5B, VARIABLE
LYMPHOCYTE RECEPTOR
B CHIMERA

(Eptatretus
burgeri;
Danio rerio) 		no annotation 4 LEU A 345
GLU A 392
ASN A 374
ILE A 376
 None
 0.93A 5jh7C-6bxaA:
undetectable		 5jh7C-6bxaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d0g PIRIN FAMILY PROTEIN

(Acinetobacter
baumannii) 		no annotation 4 LEU A 157
GLU A 173
ILE A 138
VAL A 171
 None
 1.16A 5jh7C-6d0gA:
undetectable		 5jh7C-6d0gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6es9 ACYL-COA
DEHYDROGENASE

(Paracoccus
denitrificans) 		no annotation 4 LEU A 282
VAL A 327
GLU A 350
ILE A 218
 None
 1.16A 5jh7C-6es9A:
undetectable		 5jh7C-6es9A:
undetectable