SIMILAR PATTERNS OF AMINO ACIDS FOR 5JGL_B_SAMB301_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1b7g | PROTEIN(GLYCERALDEHYDE3-PHOSPHATEDEHYDROGENASE) (Sulfolobussolfataricus) |
PF01113(DapB_N)PF02800(Gp_dh_C) | 3 | ASP O 196ASN O 140PHE O 106 | NoneSO4 O 601 ( 3.8A)None | 0.71A | 5jglB-1b7gO:undetectable | 5jglB-1b7gO:19.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bc5 | CHEMOTAXIS RECEPTORMETHYLTRANSFERASE (Salmonellaenterica) |
PF01739(CheR)PF03705(CheR_N) | 3 | ASP A 154ASN A 212PHE A 228 | SAH A 287 (-2.8A)SAH A 287 (-3.8A)None | 0.85A | 5jglB-1bc5A:11.7 | 5jglB-1bc5A:22.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1c39 | CATION-DEPENDENTMANNOSE-6-PHOSPHATERECEPTOR (Bos taurus) |
PF02157(Man-6-P_recep) | 3 | ASP A 148ASN A 90PHE A 145 | None | 0.76A | 5jglB-1c39A:undetectable | 5jglB-1c39A:18.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1cf2 | PROTEIN(GLYCERALDEHYDE-3-PHOSPHATEDEHYDROGENASE) (Methanothermusfervidus) |
no annotation | 3 | ASP P 197ASN P 141PHE P 107 | NoneSO4 P1001 (-3.5A)None | 0.88A | 5jglB-1cf2P:3.2 | 5jglB-1cf2P:23.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fio | SSO1 PROTEIN (Saccharomycescerevisiae) |
PF00804(Syntaxin) | 3 | ASP A 133ASN A 140PHE A 83 | None | 0.81A | 5jglB-1fioA:undetectable | 5jglB-1fioA:20.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1g60 | ADENINE-SPECIFICMETHYLTRANSFERASEMBOIIA (Moraxella bovis) |
PF01555(N6_N4_Mtase) | 3 | ASP A 241ASN A 11PHE A 73 | SAM A 500 (-2.9A)SAM A 500 (-4.1A)None | 0.92A | 5jglB-1g60A:3.0 | 5jglB-1g60A:20.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gme | HEAT SHOCK PROTEIN16.9B (Triticumaestivum) |
PF00011(HSP20) | 3 | ASP A 60ASN A 127PHE A 57 | None | 0.92A | 5jglB-1gmeA:undetectable | 5jglB-1gmeA:19.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gqp | DOC1/APC10 (Saccharomycescerevisiae) |
PF03256(ANAPC10) | 3 | ASP A 178ASN A 238PHE A 136 | None | 0.74A | 5jglB-1gqpA:undetectable | 5jglB-1gqpA:19.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jnf | SEROTRANSFERRIN (Oryctolaguscuniculus) |
PF00405(Transferrin) | 3 | ASP A 392ASN A 581PHE A 529 | FE A 703 ( 3.0A)NoneNone | 0.83A | 5jglB-1jnfA:undetectable | 5jglB-1jnfA:17.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kho | ALPHA-TOXIN (Clostridiumperfringens) |
PF00882(Zn_dep_PLPC)PF01477(PLAT) | 3 | ASP A 75ASN A 77PHE A 69 | None | 0.89A | 5jglB-1khoA:undetectable | 5jglB-1khoA:20.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mpp | PEPSIN (Rhizomucorpusillus) |
PF00026(Asp) | 3 | ASP A 215ASN A 219PHE A 121 | None | 0.83A | 5jglB-1mppA:undetectable | 5jglB-1mppA:23.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mqq | ALPHA-D-GLUCURONIDASE (Geobacillusstearothermophilus) |
PF03648(Glyco_hydro_67N)PF07477(Glyco_hydro_67C)PF07488(Glyco_hydro_67M) | 3 | ASP A 429ASN A 471PHE A 413 | NoneNoneGOL A 752 ( 4.6A) | 0.92A | 5jglB-1mqqA:undetectable | 5jglB-1mqqA:18.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mqt | POLYPROTEINPOLYPROTEIN CAPSIDPROTEIN (Enterovirus B;Enterovirus B) |
PF00073(Rhv)PF00073(Rhv) | 3 | ASP B 84ASN B 88PHE A 201 | None | 0.93A | 5jglB-1mqtB:undetectable | 5jglB-1mqtB:21.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mvh | CRYPTIC LOCIREGULATOR 4 (Schizosaccharomycespombe) |
PF00856(SET)PF05033(Pre-SET) | 3 | ASP A 377ASN A 373PHE A 237 | None | 0.93A | 5jglB-1mvhA:undetectable | 5jglB-1mvhA:21.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1n5x | XANTHINEDEHYDROGENASE (Bos taurus) |
PF00111(Fer2)PF00941(FAD_binding_5)PF01315(Ald_Xan_dh_C)PF01799(Fer2_2)PF02738(Ald_Xan_dh_C2)PF03450(CO_deh_flav_C) | 3 | ASP A1311ASN A1307PHE A 516 | None | 0.92A | 5jglB-1n5xA:undetectable | 5jglB-1n5xA:12.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1o4u | TYPE II QUINOLICACIDPHOSPHORIBOSYLTRANSFERASE (Thermotogamaritima) |
PF01729(QRPTase_C)PF02749(QRPTase_N) | 3 | ASP A 224ASN A 226PHE A 247 | None | 0.88A | 5jglB-1o4uA:undetectable | 5jglB-1o4uA:25.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ouu | HEMOGLOBIN IHEMOGLOBIN I (Oncorhynchusmykiss;Oncorhynchusmykiss) |
PF00042(Globin)PF00042(Globin) | 3 | ASP B 108ASN A 105PHE B 133 | None | 0.90A | 5jglB-1ouuB:undetectable | 5jglB-1ouuB:17.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qbg | NAD(P)HDEHYDROGENASE[QUINONE] 1 (Homo sapiens) |
PF02525(Flavodoxin_2) | 3 | ASP A 40ASN A 45PHE A 101 | None | 0.65A | 5jglB-1qbgA:2.5 | 5jglB-1qbgA:21.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qmh | RNA 3'-TERMINALPHOSPHATE CYCLASE (Escherichiacoli) |
PF01137(RTC)PF05189(RTC_insert) | 3 | ASP A 126ASN A 235PHE A 135 | None | 0.81A | 5jglB-1qmhA:undetectable | 5jglB-1qmhA:22.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1suv | SEROTRANSFERRIN,C-LOBE (Homo sapiens) |
PF00405(Transferrin) | 3 | ASP E 392ASN E 581PHE E 529 | FE E 703 ( 3.0A)NoneNone | 0.83A | 5jglB-1suvE:undetectable | 5jglB-1suvE:22.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vm7 | RIBOKINASE (Thermotogamaritima) |
PF00294(PfkB) | 3 | ASP A 14ASN A 104PHE A 109 | None | 0.81A | 5jglB-1vm7A:2.4 | 5jglB-1vm7A:25.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vp4 | AMINOTRANSFERASE,PUTATIVE (Thermotogamaritima) |
PF00155(Aminotran_1_2) | 3 | ASP A 215ASN A 187PHE A 246 | PLP A 501 (-2.9A)UNL A 601 ( 3.4A)None | 0.88A | 5jglB-1vp4A:undetectable | 5jglB-1vp4A:21.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1w18 | LEVANSUCRASE (Gluconacetobacterdiazotrophicus) |
PF02435(Glyco_hydro_68) | 3 | ASP A 309ASN A 306PHE A 415 | None | 0.85A | 5jglB-1w18A:undetectable | 5jglB-1w18A:19.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wst | MULTIPLE SUBSTRATEAMINOTRANSFERASE (Thermococcusprofundus) |
PF00155(Aminotran_1_2) | 3 | ASP A 222ASN A 194PHE A 253 | PLP A 418 (-2.9A)PLP A 418 (-3.7A)None | 0.85A | 5jglB-1wstA:2.5 | 5jglB-1wstA:21.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1x0m | AMINOTRANSFERASE IIHOMOLOGUE (Pyrococcushorikoshii) |
PF00155(Aminotran_1_2) | 3 | ASP A 236ASN A 208PHE A 267 | None | 0.81A | 5jglB-1x0mA:undetectable | 5jglB-1x0mA:21.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bii | NITRATE REDUCTASE[NADPH] (Ogataea angusta) |
PF00174(Oxidored_molyb)PF03404(Mo-co_dimer) | 3 | ASP A 271ASN A 199PHE A 156 | MTV A1479 ( 4.9A)NoneNone | 0.69A | 5jglB-2biiA:undetectable | 5jglB-2biiA:21.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2byu | HEAT SHOCK PROTEIN16.9B (Triticumaestivum) |
PF00011(HSP20) | 3 | ASP A 60ASN A 127PHE A 57 | None | 0.92A | 5jglB-2byuA:undetectable | 5jglB-2byuA:25.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2c1h | DELTA-AMINOLEVULINICACID DEHYDRATASE (Prosthecochlorisvibrioformis) |
PF00490(ALAD) | 3 | ASP A 313ASN A 29PHE A 269 | None | 0.74A | 5jglB-2c1hA:undetectable | 5jglB-2c1hA:24.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cg9 | ATP-DEPENDENTMOLECULAR CHAPERONEHSP82 (Saccharomycescerevisiae) |
PF00183(HSP90)PF02518(HATPase_c) | 3 | ASP A 503ASN A 446PHE A 421 | None | 0.91A | 5jglB-2cg9A:undetectable | 5jglB-2cg9A:17.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2czc | GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE (Pyrococcushorikoshii) |
PF01113(DapB_N)PF02800(Gp_dh_C) | 3 | ASP A 195ASN A 142PHE A 108 | NonePO4 A 601 (-3.3A)None | 0.65A | 5jglB-2czcA:4.1 | 5jglB-2czcA:23.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gkd | CALC (Micromonosporaechinospora) |
no annotation | 3 | ASP A 90ASN A 131PHE A 118 | None | 0.93A | 5jglB-2gkdA:undetectable | 5jglB-2gkdA:17.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2h50 | SMALL HEAT SHOCKPROTEIN HSP26 (Saccharomycescerevisiae) |
PF00011(HSP20) | 3 | ASP A 60ASN A 127PHE A 57 | None | 0.92A | 5jglB-2h50A:undetectable | 5jglB-2h50A:15.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hms | YUAA PROTEIN (Bacillussubtilis) |
PF02254(TrkA_N) | 3 | ASP A 36ASN A 56PHE A 17 | NAI A 601 (-2.9A)NAI A 601 (-3.6A)None | 0.81A | 5jglB-2hmsA:6.1 | 5jglB-2hmsA:18.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2icw | MYCOPLASMAARTHRITIDIS MITOGENT-CELL RECEPTOR BETACHAIN V (Mycoplasmaarthritidis;Mus musculus) |
PF09245(MA-Mit)PF07686(V-set) | 3 | ASP G 155ASN G 161PHE J 101 | None | 0.89A | 5jglB-2icwG:undetectable | 5jglB-2icwG:22.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2iuc | ALKALINE PHOSPHATASE (Antarcticbacterium TAB5) |
PF00245(Alk_phosphatase) | 3 | ASP B 164ASN B 190PHE B 141 | None | 0.84A | 5jglB-2iucB:undetectable | 5jglB-2iucB:21.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ix4 | 3-OXOACYL-[ACYL-CARRIER-PROTEIN]SYNTHASE (Arabidopsisthaliana) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C) | 3 | ASP A 345ASN A 342PHE A 458 | None | 0.88A | 5jglB-2ix4A:undetectable | 5jglB-2ix4A:18.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jss | CHIMERA OF HISTONEH2B.1 AND HISTONEH2A.ZUNCHARACTERIZEDPROTEIN YER030W (Saccharomycescerevisiae;Saccharomycescerevisiae) |
PF00125(Histone)PF16211(Histone_H2A_C)PF09649(CHZ) | 3 | ASP B 15ASN B 20PHE A 106 | None | 0.79A | 5jglB-2jssB:undetectable | 5jglB-2jssB:10.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2mhc | TNPX (Clostridiumperfringens) |
PF00239(Resolvase) | 3 | ASP A 117ASN A 114PHE A 96 | None | 0.74A | 5jglB-2mhcA:undetectable | 5jglB-2mhcA:19.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nnj | CYTOCHROME P450 2C8 (Homo sapiens) |
PF00067(p450) | 3 | ASP A 360ASN A 405PHE A 54 | None | 0.86A | 5jglB-2nnjA:undetectable | 5jglB-2nnjA:22.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nwh | CARBOHYDRATE KINASE (Agrobacteriumfabrum) |
PF00294(PfkB) | 3 | ASP A 139ASN A 42PHE A 83 | None | 0.80A | 5jglB-2nwhA:3.0 | 5jglB-2nwhA:23.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2oar | LARGE-CONDUCTANCEMECHANOSENSITIVECHANNEL (Mycobacteriumtuberculosis) |
PF01741(MscL) | 3 | ASP A 36ASN A 44PHE A 79 | None | 0.84A | 5jglB-2oarA:undetectable | 5jglB-2oarA:21.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2okx | RHAMNOSIDASE B (Bacillus sp.GL1) |
PF05592(Bac_rhamnosid)PF08531(Bac_rhamnosid_N)PF17389(Bac_rhamnosid6H)PF17390(Bac_rhamnosid_C) | 3 | ASP A 683ASN A 849PHE A 805 | None | 0.92A | 5jglB-2okxA:undetectable | 5jglB-2okxA:14.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q0v | UBIQUITIN-CONJUGATING ENZYME E2,PUTATIVE (Plasmodiumfalciparum) |
PF00179(UQ_con) | 3 | ASP A 86ASN A 120PHE A 24 | None | 0.82A | 5jglB-2q0vA:undetectable | 5jglB-2q0vA:17.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qtz | METHIONINE SYNTHASEREDUCTASE (Homo sapiens) |
PF00175(NAD_binding_1)PF00667(FAD_binding_1) | 3 | ASP A 304ASN A 302PHE A 523 | None | 0.89A | 5jglB-2qtzA:undetectable | 5jglB-2qtzA:20.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rmp | MUCOROPEPSIN (Rhizomucormiehei) |
PF00026(Asp) | 3 | ASP A 237ASN A 241PHE A 133 | None | 0.88A | 5jglB-2rmpA:undetectable | 5jglB-2rmpA:23.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vca | ALPHA-N-ACETYLGLUCOSAMINIDASE (Clostridiumperfringens) |
PF00754(F5_F8_type_C)PF05089(NAGLU)PF12971(NAGLU_N)PF12972(NAGLU_C) | 3 | ASP A 715ASN A 266PHE A 721 | None | 0.82A | 5jglB-2vcaA:undetectable | 5jglB-2vcaA:15.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w1z | ROP2 (Toxoplasmagondii) |
PF14531(Kinase-like) | 3 | ASP A 262ASN A 414PHE A 354 | None | 0.89A | 5jglB-2w1zA:undetectable | 5jglB-2w1zA:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xh1 | KYNURENINE/ALPHA-AMINOADIPATEAMINOTRANSFERASE,MITOCHONDRIAL (Homo sapiens) |
PF00155(Aminotran_1_2) | 3 | ASP A 230ASN A 202PHE A 261 | PLP A1427 (-2.8A)PLP A1427 (-4.1A)None | 0.90A | 5jglB-2xh1A:2.9 | 5jglB-2xh1A:21.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xmo | LMO2642 PROTEIN (Listeriamonocytogenes) |
PF00149(Metallophos) | 3 | ASP A 438ASN A 315PHE A 400 | None | 0.75A | 5jglB-2xmoA:undetectable | 5jglB-2xmoA:21.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yh2 | ESTERASE (Pyrobaculumcalidifontis) |
PF07859(Abhydrolase_3) | 3 | ASP A 172ASN A 242PHE A 237 | None | 0.92A | 5jglB-2yh2A:undetectable | 5jglB-2yh2A:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yij | PHOSPHOLIPASEA1-IIGAMMA (Arabidopsisthaliana) |
PF01764(Lipase_3) | 3 | ASP A 279ASN A 172PHE A 286 | None | 0.80A | 5jglB-2yijA:undetectable | 5jglB-2yijA:21.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3asa | LL-DIAMINOPIMELATEAMINOTRANSFERASE (Chlamydiatrachomatis) |
PF00155(Aminotran_1_2) | 3 | ASP A 202ASN A 174PHE A 234 | None | 0.74A | 5jglB-3asaA:undetectable | 5jglB-3asaA:21.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bb7 | INTERPAIN A (Prevotellaintermedia) |
PF01640(Peptidase_C10)PF13734(Inhibitor_I69) | 3 | ASP A 350ASN A 269PHE A 345 | None | 0.89A | 5jglB-3bb7A:undetectable | 5jglB-3bb7A:22.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bt6 | INFLUENZA BHEMAGGLUTININ (HA) (Influenza Bvirus) |
PF00509(Hemagglutinin) | 3 | ASP A 64ASN A 59PHE A 95 | None | 0.92A | 5jglB-3bt6A:undetectable | 5jglB-3bt6A:21.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3d3u | 4-HYDROXYBUTYRATECOA-TRANSFERASE (Porphyromonasgingivalis) |
PF02550(AcetylCoA_hydro)PF13336(AcetylCoA_hyd_C) | 3 | ASP A 140ASN A 167PHE A 30 | None | 0.87A | 5jglB-3d3uA:2.2 | 5jglB-3d3uA:20.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fdd | L-ASPARTATE-BETA-DECARBOXYLASE (Comamonastestosteroni) |
PF00155(Aminotran_1_2) | 3 | ASP A 373ASN A 380PHE A 335 | None | 0.90A | 5jglB-3fddA:2.7 | 5jglB-3fddA:19.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fy4 | 6-4 PHOTOLYASE (Arabidopsisthaliana) |
PF00875(DNA_photolyase)PF03441(FAD_binding_7) | 3 | ASP A 398ASN A 405PHE A 310 | NoneFAD A 900 ( 3.4A)None | 0.74A | 5jglB-3fy4A:1.8 | 5jglB-3fy4A:17.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gf7 | GLUTACONYL-COADECARBOXYLASESUBUNIT A ([Clostridium]symbiosum) |
PF01039(Carboxyl_trans) | 3 | ASP A 135ASN A 472PHE A 173 | None | 0.94A | 5jglB-3gf7A:undetectable | 5jglB-3gf7A:19.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ggd | SAM-DEPENDENTMETHYLTRANSFERASE (Trichormusvariabilis) |
PF13649(Methyltransf_25) | 3 | ASP A 61ASN A 66PHE A 133 | SAH A 248 ( 4.8A)NoneNone | 0.90A | 5jglB-3ggdA:13.5 | 5jglB-3ggdA:22.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i3t | UBIQUITINCARBOXYL-TERMINALHYDROLASE 21 (Homo sapiens) |
PF00443(UCH) | 3 | ASP A 399ASN A 464PHE A 305 | None | 0.87A | 5jglB-3i3tA:undetectable | 5jglB-3i3tA:19.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3j70 | MONOCLONAL ANTIBODY17B LIGHT CHAINENVELOPEGLYCOPROTEIN GP120 (Homo sapiens;Humanimmunodeficiencyvirus 1) |
PF07654(C1-set)PF07686(V-set)PF00516(GP120) | 3 | ASP A 56ASN D 325PHE D 382 | None | 0.92A | 5jglB-3j70A:undetectable | 5jglB-3j70A:21.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jb9 | PRE-MRNA-SPLICINGFACTOR CWF10 (Schizosaccharomycespombe) |
PF00009(GTP_EFTU)PF00679(EFG_C)PF03144(GTP_EFTU_D2)PF03764(EFG_IV)PF16004(EFTUD2) | 3 | ASP B 570ASN B 502PHE B 507 | None | 0.63A | 5jglB-3jb9B:undetectable | 5jglB-3jb9B:15.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jcl | SPIKE GLYCOPROTEIN (Murinecoronavirus) |
PF01601(Corona_S2)PF09408(Spike_rec_bind)PF16451(Spike_NTD) | 3 | ASP A 219ASN A 110PHE A 193 | None | 0.92A | 5jglB-3jclA:undetectable | 5jglB-3jclA:14.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k9b | LIVERCARBOXYLESTERASE 1 (Homo sapiens) |
PF00135(COesterase) | 3 | ASP A1027ASN A1204PHE A1076 | None | 0.76A | 5jglB-3k9bA:undetectable | 5jglB-3k9bA:20.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ld7 | LIN0431 PROTEIN (Listeriainnocua) |
PF07009(NusG_II) | 3 | ASP A 95ASN A 92PHE A 119 | None | 0.89A | 5jglB-3ld7A:undetectable | 5jglB-3ld7A:17.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lpd | ACIDIC EXTRACELLULARSUBTILISIN-LIKEPROTEASE APRV2 (Dichelobacternodosus) |
PF00082(Peptidase_S8) | 3 | ASP A 331ASN A 337PHE A 15 | None | 0.63A | 5jglB-3lpdA:undetectable | 5jglB-3lpdA:21.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ly1 | PUTATIVEHISTIDINOL-PHOSPHATEAMINOTRANSFERASE (Pectobacteriumatrosepticum) |
PF00155(Aminotran_1_2) | 3 | ASP A 219ASN A 192PHE A 251 | PLP A 500 (-2.7A)PLP A 500 (-3.8A)EDO A 2 ( 4.1A) | 0.88A | 5jglB-3ly1A:2.2 | 5jglB-3ly1A:22.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mgg | METHYLTRANSFERASE (Methanosarcinamazei) |
PF13847(Methyltransf_31) | 3 | ASP A 66ASN A 93PHE A 111 | None | 0.55A | 5jglB-3mggA:16.7 | 5jglB-3mggA:24.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mhx | PUTATIVE FERROUSIRON TRANSPORTPROTEIN A (Stenotrophomonasmaltophilia) |
PF04023(FeoA) | 3 | ASP A 19ASN A 23PHE A 35 | None | 0.90A | 5jglB-3mhxA:undetectable | 5jglB-3mhxA:17.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nbu | GLUCOSE-6-PHOSPHATEISOMERASE (Escherichiacoli) |
PF00342(PGI) | 3 | ASP A 74ASN A 3PHE A 83 | None | 0.88A | 5jglB-3nbuA:undetectable | 5jglB-3nbuA:21.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ng0 | GLUTAMINE SYNTHETASE (Synechocystissp. PCC 6803) |
PF00120(Gln-synt_C)PF03951(Gln-synt_N) | 3 | ASP A 236ASN A 75PHE A 24 | None | 0.80A | 5jglB-3ng0A:undetectable | 5jglB-3ng0A:20.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3o0y | LIPOPROTEIN (Colwelliapsychrerythraea) |
PF05960(DUF885) | 3 | ASP A 290ASN A 121PHE A 116 | None | 0.92A | 5jglB-3o0yA:undetectable | 5jglB-3o0yA:19.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3o90 | NICOTINAMIDASE (Streptococcuspneumoniae) |
PF00857(Isochorismatase) | 3 | ASP A 102ASN A 72PHE A 49 | None | 0.90A | 5jglB-3o90A:2.7 | 5jglB-3o90A:22.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3omn | CYTOCHROME COXIDASE, AA3 TYPE,SUBUNIT I (Rhodobactersphaeroides) |
PF00115(COX1) | 3 | ASP A 536ASN A 532PHE A 228 | None | 0.88A | 5jglB-3omnA:undetectable | 5jglB-3omnA:21.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3p09 | BETA-LACTAMASE (Francisellatularensis) |
PF13354(Beta-lactamase2) | 3 | ASP A 149ASN A 141PHE A 57 | None | 0.85A | 5jglB-3p09A:undetectable | 5jglB-3p09A:21.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pru | PHYCOBILISOME 32.1KDA LINKERPOLYPEPTIDE,PHYCOCYANIN-ASSOCIATED, ROD 1 (Synechocystissp. PCC 6803) |
no annotation | 3 | ASP C 129ASN C 123PHE C 91 | None | 0.91A | 5jglB-3pruC:undetectable | 5jglB-3pruC:19.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3psg | PEPSINOGEN (Sus scrofa) |
PF00026(Asp)PF07966(A1_Propeptide) | 3 | ASP A 11ASN A 8PHE A 286 | None | 0.78A | 5jglB-3psgA:undetectable | 5jglB-3psgA:22.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pu5 | EXTRACELLULARSOLUTE-BINDINGPROTEIN (Bordetellaparapertussis) |
PF13416(SBP_bac_8) | 3 | ASP A 136ASN A 47PHE A 92 | ASP A 136 ( 0.6A)ASN A 47 ( 0.6A)PHE A 92 ( 1.3A) | 0.92A | 5jglB-3pu5A:undetectable | 5jglB-3pu5A:24.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qqy | RIBOSOMAL PROTEIN3/HOMINGENDONUCLEASE-LIKEPROTEIN FUSION (Ophiostomanovo-ulmi) |
PF00961(LAGLIDADG_1) | 3 | ASP A 53ASN A 59PHE A 303 | None | 0.74A | 5jglB-3qqyA:undetectable | 5jglB-3qqyA:25.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3r4d | SPIKE GLYCOPROTEIN (Murinecoronavirus) |
PF16451(Spike_NTD) | 3 | ASP B 219ASN B 198PHE B 193 | None | 0.80A | 5jglB-3r4dB:undetectable | 5jglB-3r4dB:22.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rwk | INULINASE (Aspergillusficuum) |
PF00251(Glyco_hydro_32N)PF08244(Glyco_hydro_32C) | 3 | ASP X 282ASN X 223PHE X 274 | None | 0.81A | 5jglB-3rwkX:undetectable | 5jglB-3rwkX:21.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3s2s | PUTATIVEPYRAZINAMIDASE/NICOTINAMIDASE (Streptococcusmutans) |
PF00857(Isochorismatase) | 3 | ASP A 102ASN A 72PHE A 49 | None | 0.90A | 5jglB-3s2sA:2.2 | 5jglB-3s2sA:20.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3s2s | PUTATIVEPYRAZINAMIDASE/NICOTINAMIDASE (Streptococcusmutans) |
PF00857(Isochorismatase) | 3 | ASP A 102ASN A 72PHE A 99 | None | 0.86A | 5jglB-3s2sA:2.2 | 5jglB-3s2sA:20.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3s4t | AMIDOHYDROLASE 2 (Polaromonas sp.JS666) |
PF04909(Amidohydro_2) | 3 | ASP A 287ASN A 292PHE A 11 | NoneACT A 353 (-3.6A)None | 0.83A | 5jglB-3s4tA:undetectable | 5jglB-3s4tA:22.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sbu | HYPOTHETICALNTF2-LIKE PROTEIN (Bacteroidesfragilis) |
PF14254(DUF4348) | 3 | ASP A 119ASN A 246PHE A 181 | None | 0.86A | 5jglB-3sbuA:undetectable | 5jglB-3sbuA:21.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3srz | TOXIN A (Clostridioidesdifficile) |
PF12918(TcdB_N)PF12919(TcdA_TcdB) | 3 | ASP A 522ASN A 516PHE A 530 | None | 0.91A | 5jglB-3srzA:undetectable | 5jglB-3srzA:19.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3te7 | RIBOSYLDIHYDRONICOTINAMIDE DEHYDROGENASE[QUINONE] (Homo sapiens) |
PF02525(Flavodoxin_2) | 3 | ASP A 40ASN A 45PHE A 101 | None | 0.79A | 5jglB-3te7A:undetectable | 5jglB-3te7A:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ux4 | ACID-ACTIVATED UREACHANNEL (Helicobacterpylori) |
PF02293(AmiS_UreI) | 3 | ASP A 100ASN A 160PHE A 97 | None | 0.89A | 5jglB-3ux4A:undetectable | 5jglB-3ux4A:19.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3v8d | CHOLESTEROL7-ALPHA-MONOOXYGENASE (Homo sapiens) |
PF00067(p450) | 3 | ASP A 115ASN A 124PHE A 100 | None | 0.86A | 5jglB-3v8dA:undetectable | 5jglB-3v8dA:20.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vss | BETA-FRUCTOFURANOSIDASE (Microbacteriumsaccharophilum) |
PF02435(Glyco_hydro_68) | 3 | ASP A 282ASN A 279PHE A 388 | FRU A 601 (-3.1A)NoneNone | 0.86A | 5jglB-3vssA:undetectable | 5jglB-3vssA:19.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vwa | CYTOPLASMIC EXPORTPROTEIN 1 (Saccharomycescerevisiae) |
no annotation | 3 | ASP A 191ASN A 188PHE A 126 | None | 0.71A | 5jglB-3vwaA:undetectable | 5jglB-3vwaA:20.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wmt | PROBABLE FERULOYLESTERASE B-1 (Aspergillusoryzae) |
PF07519(Tannase) | 3 | ASP A 169ASN A 163PHE A 105 | NoneNoneNAG A 602 (-4.7A) | 0.91A | 5jglB-3wmtA:undetectable | 5jglB-3wmtA:20.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zi1 | GLYOXALASEDOMAIN-CONTAININGPROTEIN 4 (Homo sapiens) |
no annotation | 3 | ASP A 136ASN A 180PHE A 9 | None | 0.78A | 5jglB-3zi1A:undetectable | 5jglB-3zi1A:22.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ate | BETA-PORPHYRANASE A (Zobelliagalactanivorans) |
no annotation | 3 | ASP A 37ASN A 47PHE A 70 | None | 0.73A | 5jglB-4ateA:undetectable | 5jglB-4ateA:20.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ay9 | FOLLICLE-STIMULATINGHORMONE RECEPTOR (Homo sapiens) |
PF01462(LRRNT)PF12369(GnHR_trans)PF13306(LRR_5) | 3 | ASP X 196ASN X 240PHE X 170 | None | 0.74A | 5jglB-4ay9X:undetectable | 5jglB-4ay9X:23.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bq4 | B-AGARASE (Saccharophagusdegradans) |
PF02449(Glyco_hydro_42) | 3 | ASP A 168ASN A 173PHE A 141 | None | 0.79A | 5jglB-4bq4A:undetectable | 5jglB-4bq4A:18.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4d47 | LEVANSUCRASE (Erwiniaamylovora) |
PF02435(Glyco_hydro_68) | 3 | ASP A 203ASN A 200PHE A 301 | FRU A1415 (-2.9A)NoneNone | 0.76A | 5jglB-4d47A:undetectable | 5jglB-4d47A:21.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4eba | MRNA3'-END-PROCESSINGPROTEIN RNA14 (Kluyveromyceslactis) |
PF05843(Suf) | 3 | ASP A 570ASN A 572PHE A 532 | None | 0.75A | 5jglB-4ebaA:undetectable | 5jglB-4ebaA:18.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fim | LACTOTRANSFERRIN (Bos taurus) |
PF00405(Transferrin) | 3 | ASP A 395ASN A 594PHE A 542 | FE A 701 ( 3.1A)NoneNone | 0.88A | 5jglB-4fimA:undetectable | 5jglB-4fimA:22.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fl0 | AMINOTRANSFERASEALD1 (Arabidopsisthaliana) |
PF00155(Aminotran_1_2) | 3 | ASP A 251ASN A 223PHE A 282 | PLP A 501 (-2.8A)PLP A 501 (-3.9A)None | 0.90A | 5jglB-4fl0A:2.9 | 5jglB-4fl0A:21.00 |