SIMILAR PATTERNS OF AMINO ACIDS FOR 5JGL_B_SAMB301_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b7g PROTEIN
(GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE)


(Sulfolobus
solfataricus)
PF01113
(DapB_N)
PF02800
(Gp_dh_C)
3 ASP O 196
ASN O 140
PHE O 106
None
SO4  O 601 ( 3.8A)
None
0.71A 5jglB-1b7gO:
undetectable
5jglB-1b7gO:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bc5 CHEMOTAXIS RECEPTOR
METHYLTRANSFERASE


(Salmonella
enterica)
PF01739
(CheR)
PF03705
(CheR_N)
3 ASP A 154
ASN A 212
PHE A 228
SAH  A 287 (-2.8A)
SAH  A 287 (-3.8A)
None
0.85A 5jglB-1bc5A:
11.7
5jglB-1bc5A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c39 CATION-DEPENDENT
MANNOSE-6-PHOSPHATE
RECEPTOR


(Bos taurus)
PF02157
(Man-6-P_recep)
3 ASP A 148
ASN A  90
PHE A 145
None
0.76A 5jglB-1c39A:
undetectable
5jglB-1c39A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cf2 PROTEIN
(GLYCERALDEHYDE-3-PH
OSPHATE
DEHYDROGENASE)


(Methanothermus
fervidus)
no annotation 3 ASP P 197
ASN P 141
PHE P 107
None
SO4  P1001 (-3.5A)
None
0.88A 5jglB-1cf2P:
3.2
5jglB-1cf2P:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fio SSO1 PROTEIN

(Saccharomyces
cerevisiae)
PF00804
(Syntaxin)
3 ASP A 133
ASN A 140
PHE A  83
None
0.81A 5jglB-1fioA:
undetectable
5jglB-1fioA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g60 ADENINE-SPECIFIC
METHYLTRANSFERASE
MBOIIA


(Moraxella bovis)
PF01555
(N6_N4_Mtase)
3 ASP A 241
ASN A  11
PHE A  73
SAM  A 500 (-2.9A)
SAM  A 500 (-4.1A)
None
0.92A 5jglB-1g60A:
3.0
5jglB-1g60A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gme HEAT SHOCK PROTEIN
16.9B


(Triticum
aestivum)
PF00011
(HSP20)
3 ASP A  60
ASN A 127
PHE A  57
None
0.92A 5jglB-1gmeA:
undetectable
5jglB-1gmeA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gqp DOC1/APC10

(Saccharomyces
cerevisiae)
PF03256
(ANAPC10)
3 ASP A 178
ASN A 238
PHE A 136
None
0.74A 5jglB-1gqpA:
undetectable
5jglB-1gqpA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jnf SEROTRANSFERRIN

(Oryctolagus
cuniculus)
PF00405
(Transferrin)
3 ASP A 392
ASN A 581
PHE A 529
FE  A 703 ( 3.0A)
None
None
0.83A 5jglB-1jnfA:
undetectable
5jglB-1jnfA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kho ALPHA-TOXIN

(Clostridium
perfringens)
PF00882
(Zn_dep_PLPC)
PF01477
(PLAT)
3 ASP A  75
ASN A  77
PHE A  69
None
0.89A 5jglB-1khoA:
undetectable
5jglB-1khoA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mpp PEPSIN

(Rhizomucor
pusillus)
PF00026
(Asp)
3 ASP A 215
ASN A 219
PHE A 121
None
0.83A 5jglB-1mppA:
undetectable
5jglB-1mppA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mqq ALPHA-D-GLUCURONIDAS
E


(Geobacillus
stearothermophilus)
PF03648
(Glyco_hydro_67N)
PF07477
(Glyco_hydro_67C)
PF07488
(Glyco_hydro_67M)
3 ASP A 429
ASN A 471
PHE A 413
None
None
GOL  A 752 ( 4.6A)
0.92A 5jglB-1mqqA:
undetectable
5jglB-1mqqA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mqt POLYPROTEIN
POLYPROTEIN CAPSID
PROTEIN


(Enterovirus B;
Enterovirus B)
PF00073
(Rhv)
PF00073
(Rhv)
3 ASP B  84
ASN B  88
PHE A 201
None
0.93A 5jglB-1mqtB:
undetectable
5jglB-1mqtB:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mvh CRYPTIC LOCI
REGULATOR 4


(Schizosaccharomyces
pombe)
PF00856
(SET)
PF05033
(Pre-SET)
3 ASP A 377
ASN A 373
PHE A 237
None
0.93A 5jglB-1mvhA:
undetectable
5jglB-1mvhA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n5x XANTHINE
DEHYDROGENASE


(Bos taurus)
PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C)
3 ASP A1311
ASN A1307
PHE A 516
None
0.92A 5jglB-1n5xA:
undetectable
5jglB-1n5xA:
12.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o4u TYPE II QUINOLIC
ACID
PHOSPHORIBOSYLTRANSF
ERASE


(Thermotoga
maritima)
PF01729
(QRPTase_C)
PF02749
(QRPTase_N)
3 ASP A 224
ASN A 226
PHE A 247
None
0.88A 5jglB-1o4uA:
undetectable
5jglB-1o4uA:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ouu HEMOGLOBIN I
HEMOGLOBIN I


(Oncorhynchus
mykiss;
Oncorhynchus
mykiss)
PF00042
(Globin)
PF00042
(Globin)
3 ASP B 108
ASN A 105
PHE B 133
None
0.90A 5jglB-1ouuB:
undetectable
5jglB-1ouuB:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qbg NAD(P)H
DEHYDROGENASE
[QUINONE] 1


(Homo sapiens)
PF02525
(Flavodoxin_2)
3 ASP A  40
ASN A  45
PHE A 101
None
0.65A 5jglB-1qbgA:
2.5
5jglB-1qbgA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qmh RNA 3'-TERMINAL
PHOSPHATE CYCLASE


(Escherichia
coli)
PF01137
(RTC)
PF05189
(RTC_insert)
3 ASP A 126
ASN A 235
PHE A 135
None
0.81A 5jglB-1qmhA:
undetectable
5jglB-1qmhA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1suv SEROTRANSFERRIN,
C-LOBE


(Homo sapiens)
PF00405
(Transferrin)
3 ASP E 392
ASN E 581
PHE E 529
FE  E 703 ( 3.0A)
None
None
0.83A 5jglB-1suvE:
undetectable
5jglB-1suvE:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vm7 RIBOKINASE

(Thermotoga
maritima)
PF00294
(PfkB)
3 ASP A  14
ASN A 104
PHE A 109
None
0.81A 5jglB-1vm7A:
2.4
5jglB-1vm7A:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vp4 AMINOTRANSFERASE,
PUTATIVE


(Thermotoga
maritima)
PF00155
(Aminotran_1_2)
3 ASP A 215
ASN A 187
PHE A 246
PLP  A 501 (-2.9A)
UNL  A 601 ( 3.4A)
None
0.88A 5jglB-1vp4A:
undetectable
5jglB-1vp4A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w18 LEVANSUCRASE

(Gluconacetobacter
diazotrophicus)
PF02435
(Glyco_hydro_68)
3 ASP A 309
ASN A 306
PHE A 415
None
0.85A 5jglB-1w18A:
undetectable
5jglB-1w18A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wst MULTIPLE SUBSTRATE
AMINOTRANSFERASE


(Thermococcus
profundus)
PF00155
(Aminotran_1_2)
3 ASP A 222
ASN A 194
PHE A 253
PLP  A 418 (-2.9A)
PLP  A 418 (-3.7A)
None
0.85A 5jglB-1wstA:
2.5
5jglB-1wstA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x0m AMINOTRANSFERASE II
HOMOLOGUE


(Pyrococcus
horikoshii)
PF00155
(Aminotran_1_2)
3 ASP A 236
ASN A 208
PHE A 267
None
0.81A 5jglB-1x0mA:
undetectable
5jglB-1x0mA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bii NITRATE REDUCTASE
[NADPH]


(Ogataea angusta)
PF00174
(Oxidored_molyb)
PF03404
(Mo-co_dimer)
3 ASP A 271
ASN A 199
PHE A 156
MTV  A1479 ( 4.9A)
None
None
0.69A 5jglB-2biiA:
undetectable
5jglB-2biiA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2byu HEAT SHOCK PROTEIN
16.9B


(Triticum
aestivum)
PF00011
(HSP20)
3 ASP A  60
ASN A 127
PHE A  57
None
0.92A 5jglB-2byuA:
undetectable
5jglB-2byuA:
25.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c1h DELTA-AMINOLEVULINIC
ACID DEHYDRATASE


(Prosthecochloris
vibrioformis)
PF00490
(ALAD)
3 ASP A 313
ASN A  29
PHE A 269
None
0.74A 5jglB-2c1hA:
undetectable
5jglB-2c1hA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cg9 ATP-DEPENDENT
MOLECULAR CHAPERONE
HSP82


(Saccharomyces
cerevisiae)
PF00183
(HSP90)
PF02518
(HATPase_c)
3 ASP A 503
ASN A 446
PHE A 421
None
0.91A 5jglB-2cg9A:
undetectable
5jglB-2cg9A:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2czc GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE


(Pyrococcus
horikoshii)
PF01113
(DapB_N)
PF02800
(Gp_dh_C)
3 ASP A 195
ASN A 142
PHE A 108
None
PO4  A 601 (-3.3A)
None
0.65A 5jglB-2czcA:
4.1
5jglB-2czcA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gkd CALC

(Micromonospora
echinospora)
no annotation 3 ASP A  90
ASN A 131
PHE A 118
None
0.93A 5jglB-2gkdA:
undetectable
5jglB-2gkdA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h50 SMALL HEAT SHOCK
PROTEIN HSP26


(Saccharomyces
cerevisiae)
PF00011
(HSP20)
3 ASP A  60
ASN A 127
PHE A  57
None
0.92A 5jglB-2h50A:
undetectable
5jglB-2h50A:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hms YUAA PROTEIN

(Bacillus
subtilis)
PF02254
(TrkA_N)
3 ASP A  36
ASN A  56
PHE A  17
NAI  A 601 (-2.9A)
NAI  A 601 (-3.6A)
None
0.81A 5jglB-2hmsA:
6.1
5jglB-2hmsA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2icw MYCOPLASMA
ARTHRITIDIS MITOGEN
T-CELL RECEPTOR BETA
CHAIN V


(Mycoplasma
arthritidis;
Mus musculus)
PF09245
(MA-Mit)
PF07686
(V-set)
3 ASP G 155
ASN G 161
PHE J 101
None
0.89A 5jglB-2icwG:
undetectable
5jglB-2icwG:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iuc ALKALINE PHOSPHATASE

(Antarctic
bacterium TAB5)
PF00245
(Alk_phosphatase)
3 ASP B 164
ASN B 190
PHE B 141
None
0.84A 5jglB-2iucB:
undetectable
5jglB-2iucB:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ix4 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE


(Arabidopsis
thaliana)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
3 ASP A 345
ASN A 342
PHE A 458
None
0.88A 5jglB-2ix4A:
undetectable
5jglB-2ix4A:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jss CHIMERA OF HISTONE
H2B.1 AND HISTONE
H2A.Z
UNCHARACTERIZED
PROTEIN YER030W


(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae)
PF00125
(Histone)
PF16211
(Histone_H2A_C)
PF09649
(CHZ)
3 ASP B  15
ASN B  20
PHE A 106
None
0.79A 5jglB-2jssB:
undetectable
5jglB-2jssB:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mhc TNPX

(Clostridium
perfringens)
PF00239
(Resolvase)
3 ASP A 117
ASN A 114
PHE A  96
None
0.74A 5jglB-2mhcA:
undetectable
5jglB-2mhcA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nnj CYTOCHROME P450 2C8

(Homo sapiens)
PF00067
(p450)
3 ASP A 360
ASN A 405
PHE A  54
None
0.86A 5jglB-2nnjA:
undetectable
5jglB-2nnjA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nwh CARBOHYDRATE KINASE

(Agrobacterium
fabrum)
PF00294
(PfkB)
3 ASP A 139
ASN A  42
PHE A  83
None
0.80A 5jglB-2nwhA:
3.0
5jglB-2nwhA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oar LARGE-CONDUCTANCE
MECHANOSENSITIVE
CHANNEL


(Mycobacterium
tuberculosis)
PF01741
(MscL)
3 ASP A  36
ASN A  44
PHE A  79
None
0.84A 5jglB-2oarA:
undetectable
5jglB-2oarA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2okx RHAMNOSIDASE B

(Bacillus sp.
GL1)
PF05592
(Bac_rhamnosid)
PF08531
(Bac_rhamnosid_N)
PF17389
(Bac_rhamnosid6H)
PF17390
(Bac_rhamnosid_C)
3 ASP A 683
ASN A 849
PHE A 805
None
0.92A 5jglB-2okxA:
undetectable
5jglB-2okxA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q0v UBIQUITIN-CONJUGATIN
G ENZYME E2,
PUTATIVE


(Plasmodium
falciparum)
PF00179
(UQ_con)
3 ASP A  86
ASN A 120
PHE A  24
None
0.82A 5jglB-2q0vA:
undetectable
5jglB-2q0vA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qtz METHIONINE SYNTHASE
REDUCTASE


(Homo sapiens)
PF00175
(NAD_binding_1)
PF00667
(FAD_binding_1)
3 ASP A 304
ASN A 302
PHE A 523
None
0.89A 5jglB-2qtzA:
undetectable
5jglB-2qtzA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rmp MUCOROPEPSIN

(Rhizomucor
miehei)
PF00026
(Asp)
3 ASP A 237
ASN A 241
PHE A 133
None
0.88A 5jglB-2rmpA:
undetectable
5jglB-2rmpA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vca ALPHA-N-ACETYLGLUCOS
AMINIDASE


(Clostridium
perfringens)
PF00754
(F5_F8_type_C)
PF05089
(NAGLU)
PF12971
(NAGLU_N)
PF12972
(NAGLU_C)
3 ASP A 715
ASN A 266
PHE A 721
None
0.82A 5jglB-2vcaA:
undetectable
5jglB-2vcaA:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w1z ROP2

(Toxoplasma
gondii)
PF14531
(Kinase-like)
3 ASP A 262
ASN A 414
PHE A 354
None
0.89A 5jglB-2w1zA:
undetectable
5jglB-2w1zA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xh1 KYNURENINE/ALPHA-AMI
NOADIPATE
AMINOTRANSFERASE,
MITOCHONDRIAL


(Homo sapiens)
PF00155
(Aminotran_1_2)
3 ASP A 230
ASN A 202
PHE A 261
PLP  A1427 (-2.8A)
PLP  A1427 (-4.1A)
None
0.90A 5jglB-2xh1A:
2.9
5jglB-2xh1A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xmo LMO2642 PROTEIN

(Listeria
monocytogenes)
PF00149
(Metallophos)
3 ASP A 438
ASN A 315
PHE A 400
None
0.75A 5jglB-2xmoA:
undetectable
5jglB-2xmoA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yh2 ESTERASE

(Pyrobaculum
calidifontis)
PF07859
(Abhydrolase_3)
3 ASP A 172
ASN A 242
PHE A 237
None
0.92A 5jglB-2yh2A:
undetectable
5jglB-2yh2A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yij PHOSPHOLIPASE
A1-IIGAMMA


(Arabidopsis
thaliana)
PF01764
(Lipase_3)
3 ASP A 279
ASN A 172
PHE A 286
None
0.80A 5jglB-2yijA:
undetectable
5jglB-2yijA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3asa LL-DIAMINOPIMELATE
AMINOTRANSFERASE


(Chlamydia
trachomatis)
PF00155
(Aminotran_1_2)
3 ASP A 202
ASN A 174
PHE A 234
None
0.74A 5jglB-3asaA:
undetectable
5jglB-3asaA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bb7 INTERPAIN A

(Prevotella
intermedia)
PF01640
(Peptidase_C10)
PF13734
(Inhibitor_I69)
3 ASP A 350
ASN A 269
PHE A 345
None
0.89A 5jglB-3bb7A:
undetectable
5jglB-3bb7A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bt6 INFLUENZA B
HEMAGGLUTININ (HA)


(Influenza B
virus)
PF00509
(Hemagglutinin)
3 ASP A  64
ASN A  59
PHE A  95
None
0.92A 5jglB-3bt6A:
undetectable
5jglB-3bt6A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d3u 4-HYDROXYBUTYRATE
COA-TRANSFERASE


(Porphyromonas
gingivalis)
PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C)
3 ASP A 140
ASN A 167
PHE A  30
None
0.87A 5jglB-3d3uA:
2.2
5jglB-3d3uA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fdd L-ASPARTATE-BETA-DEC
ARBOXYLASE


(Comamonas
testosteroni)
PF00155
(Aminotran_1_2)
3 ASP A 373
ASN A 380
PHE A 335
None
0.90A 5jglB-3fddA:
2.7
5jglB-3fddA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fy4 6-4 PHOTOLYASE

(Arabidopsis
thaliana)
PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7)
3 ASP A 398
ASN A 405
PHE A 310
None
FAD  A 900 ( 3.4A)
None
0.74A 5jglB-3fy4A:
1.8
5jglB-3fy4A:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gf7 GLUTACONYL-COA
DECARBOXYLASE
SUBUNIT A


([Clostridium]
symbiosum)
PF01039
(Carboxyl_trans)
3 ASP A 135
ASN A 472
PHE A 173
None
0.94A 5jglB-3gf7A:
undetectable
5jglB-3gf7A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ggd SAM-DEPENDENT
METHYLTRANSFERASE


(Trichormus
variabilis)
PF13649
(Methyltransf_25)
3 ASP A  61
ASN A  66
PHE A 133
SAH  A 248 ( 4.8A)
None
None
0.90A 5jglB-3ggdA:
13.5
5jglB-3ggdA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i3t UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 21


(Homo sapiens)
PF00443
(UCH)
3 ASP A 399
ASN A 464
PHE A 305
None
0.87A 5jglB-3i3tA:
undetectable
5jglB-3i3tA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j70 MONOCLONAL ANTIBODY
17B LIGHT CHAIN
ENVELOPE
GLYCOPROTEIN GP120


(Homo sapiens;
Human
immunodeficiency
virus 1)
PF07654
(C1-set)
PF07686
(V-set)
PF00516
(GP120)
3 ASP A  56
ASN D 325
PHE D 382
None
0.92A 5jglB-3j70A:
undetectable
5jglB-3j70A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR CWF10


(Schizosaccharomyces
pombe)
PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03144
(GTP_EFTU_D2)
PF03764
(EFG_IV)
PF16004
(EFTUD2)
3 ASP B 570
ASN B 502
PHE B 507
None
0.63A 5jglB-3jb9B:
undetectable
5jglB-3jb9B:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jcl SPIKE GLYCOPROTEIN

(Murine
coronavirus)
PF01601
(Corona_S2)
PF09408
(Spike_rec_bind)
PF16451
(Spike_NTD)
3 ASP A 219
ASN A 110
PHE A 193
None
0.92A 5jglB-3jclA:
undetectable
5jglB-3jclA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k9b LIVER
CARBOXYLESTERASE 1


(Homo sapiens)
PF00135
(COesterase)
3 ASP A1027
ASN A1204
PHE A1076
None
0.76A 5jglB-3k9bA:
undetectable
5jglB-3k9bA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ld7 LIN0431 PROTEIN

(Listeria
innocua)
PF07009
(NusG_II)
3 ASP A  95
ASN A  92
PHE A 119
None
0.89A 5jglB-3ld7A:
undetectable
5jglB-3ld7A:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lpd ACIDIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE APRV2


(Dichelobacter
nodosus)
PF00082
(Peptidase_S8)
3 ASP A 331
ASN A 337
PHE A  15
None
0.63A 5jglB-3lpdA:
undetectable
5jglB-3lpdA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ly1 PUTATIVE
HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE


(Pectobacterium
atrosepticum)
PF00155
(Aminotran_1_2)
3 ASP A 219
ASN A 192
PHE A 251
PLP  A 500 (-2.7A)
PLP  A 500 (-3.8A)
EDO  A   2 ( 4.1A)
0.88A 5jglB-3ly1A:
2.2
5jglB-3ly1A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mgg METHYLTRANSFERASE

(Methanosarcina
mazei)
PF13847
(Methyltransf_31)
3 ASP A  66
ASN A  93
PHE A 111
None
0.55A 5jglB-3mggA:
16.7
5jglB-3mggA:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mhx PUTATIVE FERROUS
IRON TRANSPORT
PROTEIN A


(Stenotrophomonas
maltophilia)
PF04023
(FeoA)
3 ASP A  19
ASN A  23
PHE A  35
None
0.90A 5jglB-3mhxA:
undetectable
5jglB-3mhxA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nbu GLUCOSE-6-PHOSPHATE
ISOMERASE


(Escherichia
coli)
PF00342
(PGI)
3 ASP A  74
ASN A   3
PHE A  83
None
0.88A 5jglB-3nbuA:
undetectable
5jglB-3nbuA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ng0 GLUTAMINE SYNTHETASE

(Synechocystis
sp. PCC 6803)
PF00120
(Gln-synt_C)
PF03951
(Gln-synt_N)
3 ASP A 236
ASN A  75
PHE A  24
None
0.80A 5jglB-3ng0A:
undetectable
5jglB-3ng0A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o0y LIPOPROTEIN

(Colwellia
psychrerythraea)
PF05960
(DUF885)
3 ASP A 290
ASN A 121
PHE A 116
None
0.92A 5jglB-3o0yA:
undetectable
5jglB-3o0yA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o90 NICOTINAMIDASE

(Streptococcus
pneumoniae)
PF00857
(Isochorismatase)
3 ASP A 102
ASN A  72
PHE A  49
None
0.90A 5jglB-3o90A:
2.7
5jglB-3o90A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I


(Rhodobacter
sphaeroides)
PF00115
(COX1)
3 ASP A 536
ASN A 532
PHE A 228
None
0.88A 5jglB-3omnA:
undetectable
5jglB-3omnA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p09 BETA-LACTAMASE

(Francisella
tularensis)
PF13354
(Beta-lactamase2)
3 ASP A 149
ASN A 141
PHE A  57
None
0.85A 5jglB-3p09A:
undetectable
5jglB-3p09A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pru PHYCOBILISOME 32.1
KDA LINKER
POLYPEPTIDE,
PHYCOCYANIN-ASSOCIAT
ED, ROD 1


(Synechocystis
sp. PCC 6803)
no annotation 3 ASP C 129
ASN C 123
PHE C  91
None
0.91A 5jglB-3pruC:
undetectable
5jglB-3pruC:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3psg PEPSINOGEN

(Sus scrofa)
PF00026
(Asp)
PF07966
(A1_Propeptide)
3 ASP A  11
ASN A   8
PHE A 286
None
0.78A 5jglB-3psgA:
undetectable
5jglB-3psgA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pu5 EXTRACELLULAR
SOLUTE-BINDING
PROTEIN


(Bordetella
parapertussis)
PF13416
(SBP_bac_8)
3 ASP A 136
ASN A  47
PHE A  92
ASP  A 136 ( 0.6A)
ASN  A  47 ( 0.6A)
PHE  A  92 ( 1.3A)
0.92A 5jglB-3pu5A:
undetectable
5jglB-3pu5A:
24.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qqy RIBOSOMAL PROTEIN
3/HOMING
ENDONUCLEASE-LIKE
PROTEIN FUSION


(Ophiostoma
novo-ulmi)
PF00961
(LAGLIDADG_1)
3 ASP A  53
ASN A  59
PHE A 303
None
0.74A 5jglB-3qqyA:
undetectable
5jglB-3qqyA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r4d SPIKE GLYCOPROTEIN

(Murine
coronavirus)
PF16451
(Spike_NTD)
3 ASP B 219
ASN B 198
PHE B 193
None
0.80A 5jglB-3r4dB:
undetectable
5jglB-3r4dB:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rwk INULINASE

(Aspergillus
ficuum)
PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C)
3 ASP X 282
ASN X 223
PHE X 274
None
0.81A 5jglB-3rwkX:
undetectable
5jglB-3rwkX:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s2s PUTATIVE
PYRAZINAMIDASE/NICOT
INAMIDASE


(Streptococcus
mutans)
PF00857
(Isochorismatase)
3 ASP A 102
ASN A  72
PHE A  49
None
0.90A 5jglB-3s2sA:
2.2
5jglB-3s2sA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s2s PUTATIVE
PYRAZINAMIDASE/NICOT
INAMIDASE


(Streptococcus
mutans)
PF00857
(Isochorismatase)
3 ASP A 102
ASN A  72
PHE A  99
None
0.86A 5jglB-3s2sA:
2.2
5jglB-3s2sA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s4t AMIDOHYDROLASE 2

(Polaromonas sp.
JS666)
PF04909
(Amidohydro_2)
3 ASP A 287
ASN A 292
PHE A  11
None
ACT  A 353 (-3.6A)
None
0.83A 5jglB-3s4tA:
undetectable
5jglB-3s4tA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sbu HYPOTHETICAL
NTF2-LIKE PROTEIN


(Bacteroides
fragilis)
PF14254
(DUF4348)
3 ASP A 119
ASN A 246
PHE A 181
None
0.86A 5jglB-3sbuA:
undetectable
5jglB-3sbuA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3srz TOXIN A

(Clostridioides
difficile)
PF12918
(TcdB_N)
PF12919
(TcdA_TcdB)
3 ASP A 522
ASN A 516
PHE A 530
None
0.91A 5jglB-3srzA:
undetectable
5jglB-3srzA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3te7 RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE]


(Homo sapiens)
PF02525
(Flavodoxin_2)
3 ASP A  40
ASN A  45
PHE A 101
None
0.79A 5jglB-3te7A:
undetectable
5jglB-3te7A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ux4 ACID-ACTIVATED UREA
CHANNEL


(Helicobacter
pylori)
PF02293
(AmiS_UreI)
3 ASP A 100
ASN A 160
PHE A  97
None
0.89A 5jglB-3ux4A:
undetectable
5jglB-3ux4A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v8d CHOLESTEROL
7-ALPHA-MONOOXYGENAS
E


(Homo sapiens)
PF00067
(p450)
3 ASP A 115
ASN A 124
PHE A 100
None
0.86A 5jglB-3v8dA:
undetectable
5jglB-3v8dA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vss BETA-FRUCTOFURANOSID
ASE


(Microbacterium
saccharophilum)
PF02435
(Glyco_hydro_68)
3 ASP A 282
ASN A 279
PHE A 388
FRU  A 601 (-3.1A)
None
None
0.86A 5jglB-3vssA:
undetectable
5jglB-3vssA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vwa CYTOPLASMIC EXPORT
PROTEIN 1


(Saccharomyces
cerevisiae)
no annotation 3 ASP A 191
ASN A 188
PHE A 126
None
0.71A 5jglB-3vwaA:
undetectable
5jglB-3vwaA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wmt PROBABLE FERULOYL
ESTERASE B-1


(Aspergillus
oryzae)
PF07519
(Tannase)
3 ASP A 169
ASN A 163
PHE A 105
None
None
NAG  A 602 (-4.7A)
0.91A 5jglB-3wmtA:
undetectable
5jglB-3wmtA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zi1 GLYOXALASE
DOMAIN-CONTAINING
PROTEIN 4


(Homo sapiens)
no annotation 3 ASP A 136
ASN A 180
PHE A   9
None
0.78A 5jglB-3zi1A:
undetectable
5jglB-3zi1A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ate BETA-PORPHYRANASE A

(Zobellia
galactanivorans)
no annotation 3 ASP A  37
ASN A  47
PHE A  70
None
0.73A 5jglB-4ateA:
undetectable
5jglB-4ateA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ay9 FOLLICLE-STIMULATING
HORMONE RECEPTOR


(Homo sapiens)
PF01462
(LRRNT)
PF12369
(GnHR_trans)
PF13306
(LRR_5)
3 ASP X 196
ASN X 240
PHE X 170
None
0.74A 5jglB-4ay9X:
undetectable
5jglB-4ay9X:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bq4 B-AGARASE

(Saccharophagus
degradans)
PF02449
(Glyco_hydro_42)
3 ASP A 168
ASN A 173
PHE A 141
None
0.79A 5jglB-4bq4A:
undetectable
5jglB-4bq4A:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d47 LEVANSUCRASE

(Erwinia
amylovora)
PF02435
(Glyco_hydro_68)
3 ASP A 203
ASN A 200
PHE A 301
FRU  A1415 (-2.9A)
None
None
0.76A 5jglB-4d47A:
undetectable
5jglB-4d47A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eba MRNA
3'-END-PROCESSING
PROTEIN RNA14


(Kluyveromyces
lactis)
PF05843
(Suf)
3 ASP A 570
ASN A 572
PHE A 532
None
0.75A 5jglB-4ebaA:
undetectable
5jglB-4ebaA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fim LACTOTRANSFERRIN

(Bos taurus)
PF00405
(Transferrin)
3 ASP A 395
ASN A 594
PHE A 542
FE  A 701 ( 3.1A)
None
None
0.88A 5jglB-4fimA:
undetectable
5jglB-4fimA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fl0 AMINOTRANSFERASE
ALD1


(Arabidopsis
thaliana)
PF00155
(Aminotran_1_2)
3 ASP A 251
ASN A 223
PHE A 282
PLP  A 501 (-2.8A)
PLP  A 501 (-3.9A)
None
0.90A 5jglB-4fl0A:
2.9
5jglB-4fl0A:
21.00