SIMILAR PATTERNS OF AMINO ACIDS FOR 5JGL_B_SAMB301_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eh6 O6-ALKYLGUANINE-DNA
ALKYLTRANSFERASE

(Homo sapiens) 		PF01035
(DNA_binding_1)
PF02870
(Methyltransf_1N) 		5 ALA A 170
GLY A 173
LEU A 168
LEU A 181
GLY A 177
 None
 1.18A 5jglB-1eh6A:
undetectable		 5jglB-1eh6A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m22 PEPTIDE AMIDASE

(Stenotrophomonas
maltophilia) 		PF01425
(Amidase) 		5 THR A 133
GLY A 163
ALA A 159
LEU A 115
ALA A 128
 None
 1.25A 5jglB-1m22A:
undetectable		 5jglB-1m22A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nbw GLYCEROL DEHYDRATASE
REACTIVASE ALPHA
SUBUNIT
GLYCEROL DEHYDRATASE
REACTIVASE BETA
SUBUNIT

(Klebsiella
pneumoniae;
Klebsiella
pneumoniae) 		PF08841
(DDR)
PF02288
(Dehydratase_MU) 		5 THR A 104
GLY B  28
LEU B 100
LEU B  85
SER B 114
 None
 1.13A 5jglB-1nbwA:
undetectable		 5jglB-1nbwA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u0u DIHYDROPINOSYLVIN
SYNTHASE

(Pinus
sylvestris) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		5 ALA A 181
ALA A 177
LEU A 174
ALA A  15
SER A  20
 None
 1.43A 5jglB-1u0uA:
undetectable		 5jglB-1u0uA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u60 PROBABLE GLUTAMINASE
YBAS

(Escherichia
coli) 		PF04960
(Glutaminase) 		5 GLY A 245
ALA A 103
LEU A 104
SER A 113
PRO A 111
 None
 1.34A 5jglB-1u60A:
undetectable		 5jglB-1u60A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u60 PROBABLE GLUTAMINASE
YBAS

(Escherichia
coli) 		PF04960
(Glutaminase) 		5 GLY A 265
ALA A 147
LEU A 146
ALA A  63
SER A  68
 None
 1.20A 5jglB-1u60A:
undetectable		 5jglB-1u60A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vl5 UNKNOWN CONSERVED
PROTEIN BH2331

(Bacillus
halodurans) 		PF08241
(Methyltransf_11) 		5 ALA A  50
GLY A  52
LEU A  72
ALA A  99
PRO A 122
 None
 0.56A 5jglB-1vl5A:
18.4		 5jglB-1vl5A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w5e FTSZ

(Methanocaldococcus
jannaschii) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		5 THR A 316
ALA A 249
GLY A 339
LEU A 187
ALA A 285
 None
 0.71A 5jglB-1w5eA:
4.3		 5jglB-1w5eA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w61 B-CELL MITOGEN

(Trypanosoma
cruzi) 		PF05544
(Pro_racemase) 		5 GLY A 131
ALA A 164
LEU A 262
GLY A 216
SER A 191
 PYC  A 700 (-3.7A)
None
None
None
None
 1.41A 5jglB-1w61A:
undetectable		 5jglB-1w61A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wzn SAM-DEPENDENT
METHYLTRANSFERASE

(Pyrococcus
horikoshii) 		PF13649
(Methyltransf_25) 		5 ALA A  49
GLY A  51
LEU A  71
MET A  75
LEU A  98
 SAH  A1001 (-3.4A)
SAH  A1001 (-3.1A)
SAH  A1001 (-3.9A)
SAH  A1001 (-4.4A)
None
 0.76A 5jglB-1wznA:
14.8		 5jglB-1wznA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x0l HOMOISOCITRATE
DEHYDROGENASE

(Thermus
thermophilus) 		PF00180
(Iso_dh) 		5 ALA A  70
GLY A 261
ALA A  83
LEU A  87
GLY A  10
 None
 0.97A 5jglB-1x0lA:
undetectable		 5jglB-1x0lA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yr2 PROLYL
OLIGOPEPTIDASE

(Novosphingobium
capsulatum) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		5 ALA A 519
GLY A 517
LEU A 491
ALA A 521
ALA A 484
 None
 1.31A 5jglB-1yr2A:
undetectable		 5jglB-1yr2A:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2an1 PUTATIVE KINASE

(Salmonella
enterica) 		PF01513
(NAD_kinase) 		5 GLY A  55
ALA A  67
LEU A  66
ALA A  58
GLY A  61
 GLY  A  55 ( 0.0A)
ALA  A  67 ( 0.0A)
LEU  A  66 ( 0.6A)
ALA  A  58 ( 0.0A)
GLY  A  61 ( 0.0A)
 1.26A 5jglB-2an1A:
undetectable		 5jglB-2an1A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ash QUEUINE
TRNA-RIBOSYLTRANSFER
ASE

(Thermotoga
maritima) 		PF01702
(TGT) 		5 THR A 161
ALA A 208
GLY A 181
LEU A 252
GLY A 210
 None
None
None
None
EDO  A 404 (-3.4A)
 1.07A 5jglB-2ashA:
undetectable		 5jglB-2ashA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fyi HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CBL

(Escherichia
coli) 		PF03466
(LysR_substrate) 		5 ALA A  98
GLY A 129
LEU A  95
ALA A 148
GLY A 146
 None
 1.42A 5jglB-2fyiA:
undetectable		 5jglB-2fyiA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gu3 YPMB PROTEIN

(Bacillus
subtilis) 		PF03413
(PepSY) 		5 ALA A  41
GLY A  37
ALA A  45
LEU A  51
ALA A  85
 None
 0.93A 5jglB-2gu3A:
undetectable		 5jglB-2gu3A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h5g DELTA
1-PYRROLINE-5-CARBOX
YLATE SYNTHETASE

(Homo sapiens) 		PF00171
(Aldedh) 		5 ALA A 737
GLY A 730
LEU A 754
ALA A 492
GLY A 439
 None
 0.90A 5jglB-2h5gA:
2.7		 5jglB-2h5gA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ivp O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE

(Pyrococcus
abyssi) 		PF00814
(Peptidase_M22) 		5 ALA A  83
GLY A  81
ALA A  10
GLY A   8
SER A  75
 None
None
ATP  A1327 ( 3.7A)
None
None
 1.27A 5jglB-2ivpA:
undetectable		 5jglB-2ivpA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iw1 LIPOPOLYSACCHARIDE
CORE BIOSYNTHESIS
PROTEIN RFAG

(Escherichia
coli) 		PF00534
(Glycos_transf_1)
PF13439
(Glyco_transf_4) 		5 GLY A 203
LEU A 245
ALA A 278
GLY A 210
SER A 214
 U2F  A 900 ( 4.3A)
None
None
None
None
 1.41A 5jglB-2iw1A:
2.0		 5jglB-2iw1A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2opj O-SUCCINYLBENZOATE-C
OA SYNTHASE

(Thermobifida
fusca) 		PF13378
(MR_MLE_C) 		5 THR A  14
ALA A  84
ALA A 116
ALA A  78
GLY A  80
 None
 1.27A 5jglB-2opjA:
undetectable		 5jglB-2opjA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p0l LIPOATE-PROTEIN
LIGASE A

(Streptococcus
agalactiae) 		PF03099
(BPL_LplA_LipB) 		5 GLY A  99
LEU A 221
ALA A 163
LEU A 155
ALA A  96
 None
 1.17A 5jglB-2p0lA:
undetectable		 5jglB-2p0lA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pd1 HYPOTHETICAL PROTEIN

(Nitrosomonas
europaea) 		no annotation 5 ALA A  64
GLY A  68
ALA A  60
GLY A  36
SER A  35
 None
 1.31A 5jglB-2pd1A:
undetectable		 5jglB-2pd1A:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pd3 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]

(Helicobacter
pylori) 		PF13561
(adh_short_C2) 		5 THR A 193
LEU A 126
ALA A  15
GLY A  13
SER A  91
 NAD  A1780 (-3.2A)
None
NAD  A1780 (-3.4A)
NAD  A1780 (-3.7A)
NAD  A1780 ( 3.7A)
 1.27A 5jglB-2pd3A:
5.2		 5jglB-2pd3A:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qnu UNCHARACTERIZED
PROTEIN PA0076

(Pseudomonas
aeruginosa) 		PF09867
(DUF2094) 		5 ALA A  99
LEU A  95
ALA A 170
GLY A 103
PRO A 142
 None
 1.32A 5jglB-2qnuA:
undetectable		 5jglB-2qnuA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qny 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Mycobacterium
tuberculosis) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 GLY A 180
LEU A 308
ALA A 216
ALA A 312
GLY A 303
 None
 1.03A 5jglB-2qnyA:
undetectable		 5jglB-2qnyA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qvw GLP_546_48378_50642

(Giardia
intestinalis) 		PF00636
(Ribonuclease_3)
PF02170
(PAZ) 		5 ALA A 341
LEU A 337
ALA A 661
LEU A 664
ALA A 654
 None
 1.11A 5jglB-2qvwA:
undetectable		 5jglB-2qvwA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r9z GLUTATHIONE AMIDE
REDUCTASE

(Marichromatium
gracile) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 ALA A 137
GLY A 139
ALA A   9
LEU A   7
GLY A  15
 FAD  A 500 (-4.1A)
FAD  A 500 (-3.2A)
None
None
FAD  A 500 (-3.5A)
 1.27A 5jglB-2r9zA:
undetectable		 5jglB-2r9zA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rbc SUGAR KINASE

(Agrobacterium
fabrum) 		PF00294
(PfkB) 		5 ALA A  16
LEU A  18
ALA A  99
ALA A  47
GLY A  45
 None
None
None
None
GOL  A 333 ( 4.1A)
 1.41A 5jglB-2rbcA:
2.8		 5jglB-2rbcA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xts SULFITE
DEHYDROGENASE

(Paracoccus
pantotrophus) 		PF00174
(Oxidored_molyb)
PF03404
(Mo-co_dimer) 		5 LEU A 380
ALA A 330
GLY A 328
SER A 327
PRO A 311
 None
None
None
GOL  A1433 ( 4.3A)
None
 1.33A 5jglB-2xtsA:
undetectable		 5jglB-2xtsA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y7c TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN

(Escherichia
coli) 		PF02384
(N6_Mtase)
PF12161
(HsdM_N) 		5 THR B 151
ALA B 175
GLY B 177
LEU B 217
LEU B 250
 None
 1.09A 5jglB-2y7cB:
11.2		 5jglB-2y7cB:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c4a PROBABLE TRYPTOPHAN
HYDROXYLASE VIOD

(Chromobacterium
violaceum) 		no annotation 5 ALA A 138
GLY A 140
LEU A 271
LEU A 292
GLY A  12
 None
FAD  A 401 (-3.4A)
None
None
None
 1.19A 5jglB-3c4aA:
2.6		 5jglB-3c4aA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dm9 SIGNAL RECOGNITION
PARTICLE RECEPTOR

(Pyrococcus
furiosus) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		5 ALA B 245
LEU B 269
ALA B  60
GLY B 279
SER B 283
 None
 1.13A 5jglB-3dm9B:
2.4		 5jglB-3dm9B:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e1t HALOGENASE

(Chondromyces
crocatus) 		PF04820
(Trp_halogenase) 		5 ALA A  27
LEU A  10
ALA A  23
LEU A  35
GLY A 125
 None
 1.43A 5jglB-3e1tA:
undetectable		 5jglB-3e1tA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3edm SHORT CHAIN
DEHYDROGENASE

(Agrobacterium
fabrum) 		PF13561
(adh_short_C2) 		5 ALA A  23
GLY A  19
ALA A  27
LEU A  54
ALA A  44
 None
 1.38A 5jglB-3edmA:
6.4		 5jglB-3edmA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eya PYRUVATE
DEHYDROGENASE
[CYTOCHROME]

(Escherichia
coli) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 ALA A  56
LEU A 416
ALA A  71
GLY A  23
SER A  46
 None
 1.11A 5jglB-3eyaA:
undetectable		 5jglB-3eyaA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h2i ESTERASE

(Xanthomonas
oryzae) 		PF03583
(LIP) 		5 THR A 181
GLY A  83
LEU A  67
ALA A 154
LEU A   7
 None
 1.43A 5jglB-3h2iA:
undetectable		 5jglB-3h2iA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica) 		PF03063
(Prismane) 		5 ALA A 590
GLY A 592
ALA A 110
GLY A 586
SER A 585
 None
None
None
None
XCC  A 800 (-2.9A)
 1.36A 5jglB-3i04A:
undetectable		 5jglB-3i04A:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ics COENZYME A-DISULFIDE
REDUCTASE

(Bacillus
anthracis) 		PF00581
(Rhodanese)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 ALA A  12
GLY A  14
ALA A 302
LEU A 301
PRO A 300
 FAD  A 555 ( 3.2A)
None
FAD  A 555 ( 3.4A)
FAD  A 555 (-3.8A)
None
 1.36A 5jglB-3icsA:
3.1		 5jglB-3icsA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k2n SIGMA-54-DEPENDENT
TRANSCRIPTIONAL
REGULATOR

(Chlorobaculum
tepidum) 		PF13185
(GAF_2) 		5 ALA A 158
LEU A 122
GLY A 152
SER A 151
PRO A 121
 None
 1.44A 5jglB-3k2nA:
undetectable		 5jglB-3k2nA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m49 TRANSKETOLASE

(Bacillus
anthracis) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 ALA A 125
GLY A 127
MET A 130
ALA A 153
GLY A 121
 None
 1.07A 5jglB-3m49A:
3.7		 5jglB-3m49A:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdu N-FORMIMINO-L-GLUTAM
ATE IMINOHYDROLASE

(Pseudomonas
aeruginosa) 		PF01979
(Amidohydro_1) 		5 LEU A  11
ALA A 380
LEU A  29
ALA A 366
GLY A 377
 None
 0.90A 5jglB-3mduA:
undetectable		 5jglB-3mduA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o0k ALDO/KETO REDUCTASE

(Brucella
abortus) 		PF00248
(Aldo_ket_red) 		5 ALA A 232
LEU A 236
GLY A 210
SER A 207
PRO A 248
 None
 1.38A 5jglB-3o0kA:
undetectable		 5jglB-3o0kA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opy 6-PHOSPHOFRUCTO-1-KI
NASE BETA-SUBUNIT

(Komagataella
pastoris) 		PF00365
(PFK) 		5 TYR B 221
ALA B 328
GLY B 330
MET B 196
ALA B 488
 None
 1.32A 5jglB-3opyB:
undetectable		 5jglB-3opyB:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q1x SERINE
ACETYLTRANSFERASE

(Entamoeba
histolytica) 		PF00132
(Hexapep) 		5 TYR A 199
THR A 231
ALA A 109
LEU A 107
GLY A 113
 None
 1.29A 5jglB-3q1xA:
undetectable		 5jglB-3q1xA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qp9 TYPE I POLYKETIDE
SYNTHASE PIKAII

(Streptomyces
venezuelae) 		PF08659
(KR) 		5 ALA A  94
GLY A 110
LEU A  92
LEU A 175
ALA A 150
 None
 1.45A 5jglB-3qp9A:
2.4		 5jglB-3qp9A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3trh PHOSPHORIBOSYLAMINOI
MIDAZOLE CARBOXYLASE
CARBOXYLTRANSFERASE
SUBUNIT

(Coxiella
burnetii) 		PF00731
(AIRC) 		5 ALA A  66
GLY A  11
LEU A  68
ALA A  99
ALA A  64
 None
 1.40A 5jglB-3trhA:
undetectable		 5jglB-3trhA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tsm INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE

(Brucella
abortus) 		PF00218
(IGPS) 		5 GLY A 221
LEU A 209
ALA A 213
GLY A 238
SER A 237
 None
 1.16A 5jglB-3tsmA:
undetectable		 5jglB-3tsmA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ufk UNDA

(Shewanella sp.
HRCR_06) 		PF13435
(Cytochrome_C554) 		5 ALA A 308
GLY A 312
ALA A 304
LEU A 384
ALA A 315
 None
 1.29A 5jglB-3ufkA:
undetectable		 5jglB-3ufkA:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uk1 TRANSKETOLASE

(Burkholderia
thailandensis) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 GLY A 181
ALA A 469
LEU A 470
ALA A 186
GLY A 438
 None
 0.87A 5jglB-3uk1A:
2.3		 5jglB-3uk1A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v8x TRANSFERRIN-BINDING
PROTEIN 1

(Neisseria
meningitidis) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		5 ALA A 218
GLY A 211
LEU A 220
LEU A 331
ALA A 216
 None
 1.12A 5jglB-3v8xA:
undetectable		 5jglB-3v8xA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vss BETA-FRUCTOFURANOSID
ASE

(Microbacterium
saccharophilum) 		PF02435
(Glyco_hydro_68) 		5 THR A 503
GLY A 430
LEU A 400
GLY A 426
SER A 425
 None
 1.22A 5jglB-3vssA:
undetectable		 5jglB-3vssA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4av6 K(+)-STIMULATED
PYROPHOSPHATE-ENERGI
ZED SODIUM PUMP

(Thermotoga
maritima) 		PF03030
(H_PPase) 		5 ALA A 431
LEU A 429
ALA A 366
GLY A 369
SER A 372
 None
 1.06A 5jglB-4av6A:
undetectable		 5jglB-4av6A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4av6 K(+)-STIMULATED
PYROPHOSPHATE-ENERGI
ZED SODIUM PUMP

(Thermotoga
maritima) 		PF03030
(H_PPase) 		5 ALA A 653
GLY A 657
ALA A 649
ALA A 380
GLY A 500
 None
 1.16A 5jglB-4av6A:
undetectable		 5jglB-4av6A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4av6 K(+)-STIMULATED
PYROPHOSPHATE-ENERGI
ZED SODIUM PUMP

(Thermotoga
maritima) 		PF03030
(H_PPase) 		5 ALA A 653
GLY A 657
ALA A 649
LEU A 702
ALA A 495
 None
None
None
None
K  A1733 (-3.7A)
 1.20A 5jglB-4av6A:
undetectable		 5jglB-4av6A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4av6 K(+)-STIMULATED
PYROPHOSPHATE-ENERGI
ZED SODIUM PUMP

(Thermotoga
maritima) 		PF03030
(H_PPase) 		5 ALA A 653
GLY A 657
LEU A 651
ALA A 649
ALA A 495
 None
None
None
None
K  A1733 (-3.7A)
 1.31A 5jglB-4av6A:
undetectable		 5jglB-4av6A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bjp PENICILLIN BINDING
PROTEIN
TRANSPEPTIDASE
DOMAIN PROTEIN

(Escherichia
coli) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		5 LEU A 428
ALA A 544
GLY A 496
SER A 307
PRO A 305
 None
None
GOL  A 630 (-3.5A)
GOL  A 630 (-2.9A)
None
 1.37A 5jglB-4bjpA:
undetectable		 5jglB-4bjpA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bpl IMPORTIN SUBUNIT
ALPHA-1A

(Oryza sativa) 		PF00514
(Arm)
PF16186
(Arm_3) 		5 ALA A  92
LEU A  90
ALA A  76
GLY A  80
SER A  83
 None
 1.23A 5jglB-4bplA:
undetectable		 5jglB-4bplA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cza NA+/H+ ANTIPORTER,
PUTATIVE

(Pyrococcus
abyssi) 		PF00999
(Na_H_Exchanger) 		5 ALA A 124
GLY A 127
ALA A 169
LEU A 173
ALA A 104
 None
 1.35A 5jglB-4czaA:
undetectable		 5jglB-4czaA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d1i BETA-GALACTOSIDASE,
PUTATIVE, BGL35A

(Cellvibrio
japonicus) 		PF02449
(Glyco_hydro_42) 		5 ALA A 511
GLY A 475
ALA A 508
LEU A 405
GLY A 492
 None
 1.25A 5jglB-4d1iA:
2.4		 5jglB-4d1iA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4evz HISF-LUCA

(synthetic
construct) 		PF00977
(His_biosynth) 		5 GLY A 144
ALA A 105
LEU A 112
ALA A  54
GLY A  82
 None
None
None
None
PI  A 302 (-3.6A)
 0.90A 5jglB-4evzA:
undetectable		 5jglB-4evzA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g9k ROTENONE-INSENSITIVE
NADH-UBIQUINONE
OXIDOREDUCTASE

(Saccharomyces
cerevisiae) 		PF07992
(Pyr_redox_2) 		5 ALA A 385
ALA A 387
ALA A 175
GLY A 382
PRO A 390
 ALA  A 385 ( 0.0A)
ALA  A 387 ( 0.0A)
ALA  A 175 (-0.0A)
GLY  A 382 (-0.0A)
PRO  A 390 ( 1.1A)
 1.45A 5jglB-4g9kA:
3.0		 5jglB-4g9kA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4grx AMINOTRANSFERASE

(Paracoccus
denitrificans) 		PF00202
(Aminotran_3) 		5 GLY A 374
LEU A 423
GLY A 230
SER A 420
PRO A 416
 None
 0.88A 5jglB-4grxA:
undetectable		 5jglB-4grxA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ihe THNT PROTEIN

(Streptomyces
cattleya) 		PF03576
(Peptidase_S58) 		5 THR A  58
ALA A 375
GLY A 180
LEU A 377
ALA A 215
 None
 1.20A 5jglB-4iheA:
undetectable		 5jglB-4iheA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iig BETA-GLUCOSIDASE 1

(Aspergillus
aculeatus) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 GLY A 142
ALA A 108
LEU A 573
ALA A 145
GLY A 160
 None
 1.29A 5jglB-4iigA:
undetectable		 5jglB-4iigA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ix2 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Vibrio cholerae) 		PF00478
(IMPDH) 		5 THR A  29
ALA A 459
ALA A 450
GLY A 448
PRO A  20
 None
 1.40A 5jglB-4ix2A:
undetectable		 5jglB-4ix2A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o99 ACETYL-COA
ACETYLTRANSFERASE

(Cupriavidus
necator) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 GLY A  54
ALA A  70
LEU A  75
ALA A  26
GLY A  30
 None
 0.92A 5jglB-4o99A:
undetectable		 5jglB-4o99A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ovy HALOACID
DEHALOGENASE DOMAIN
PROTEIN HYDROLASE

(Planctopirus
limnophila) 		PF12710
(HAD) 		5 GLY A 187
MET A 191
ALA A  83
LEU A  84
ALA A 119
 None
None
None
None
EDO  A 407 (-3.6A)
 1.35A 5jglB-4ovyA:
undetectable		 5jglB-4ovyA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p69 ISOCITRATE
DEHYDROGENASE
KINASE/PHOSPHATASE

(Escherichia
coli) 		PF06315
(AceK) 		5 GLY A 232
ALA A 207
LEU A 200
ALA A  38
PRO A 161
 None
 1.25A 5jglB-4p69A:
undetectable		 5jglB-4p69A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT D
NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT E

(Vibrio
cholerae;
Vibrio cholerae) 		PF02508
(Rnf-Nqr)
PF02508
(Rnf-Nqr) 		5 ALA E 187
GLY E 189
ALA D 184
LEU D  32
SER E  20
 None
 1.35A 5jglB-4p6vE:
undetectable		 5jglB-4p6vE:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rm4 CYTOCHROME P450

(Bacillus
subtilis) 		PF00067
(p450) 		5 ALA A 355
GLY A 351
LEU A 357
ALA A 359
PRO A 273
 HEM  A 401 (-3.5A)
HEM  A 401 (-3.5A)
None
None
None
 0.90A 5jglB-4rm4A:
undetectable		 5jglB-4rm4A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wxz PYRIDOXAL
BIOSYNTHESIS LYASE
PDXS

(Geobacillus
kaustophilus) 		PF01680
(SOR_SNZ) 		5 ALA A 211
GLY A 231
ALA A 160
ALA A 221
PRO A 152
 None
None
None
None
L5P  A  81 ( 4.2A)
 1.02A 5jglB-4wxzA:
undetectable		 5jglB-4wxzA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xii CHOLINESTERASE

(Homo sapiens) 		PF00135
(COesterase) 		5 THR A 243
LEU A  93
ALA A 150
GLY A 152
PRO A  46
 None
 1.27A 5jglB-4xiiA:
undetectable		 5jglB-4xiiA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8r METHYL-COENZYME M
REDUCTASE II SUBUNIT
ALPHA

(Methanothermobacter
marburgensis) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N) 		5 ALA A 115
LEU A 119
ALA A 231
GLY A 235
SER A 237
 None
 1.14A 5jglB-5a8rA:
undetectable		 5jglB-5a8rA:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ch8 MONO- AND
DIACYLGLYCEROL
LIPASE

(Penicillium
cyclopium) 		PF01764
(Lipase_3)
PF03893
(Lipase3_N) 		5 TYR A  21
ALA A 151
LEU A 153
ALA A  79
GLY A 143
 CL  A 304 (-4.7A)
None
None
None
None
 1.41A 5jglB-5ch8A:
undetectable		 5jglB-5ch8A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ecu CELLULASE

(Caldicellulosiruptor
saccharolyticus) 		PF00150
(Cellulase)
PF03424
(CBM_17_28) 		5 ALA A 302
LEU A 299
GLY A 287
SER A 289
PRO A 297
 None
ACT  A 636 (-4.3A)
None
None
None
 1.35A 5jglB-5ecuA:
undetectable		 5jglB-5ecuA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fip GH5 CELLULASE

(unidentified) 		PF00150
(Cellulase)
PF03424
(CBM_17_28) 		5 ALA A 311
LEU A 308
GLY A 296
SER A 298
PRO A 306
 None
PEG  A1386 (-3.8A)
None
None
PEG  A1386 (-4.8A)
 1.34A 5jglB-5fipA:
undetectable		 5jglB-5fipA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fql IDURONATE-2-SULFATAS
E

(Homo sapiens) 		PF00884
(Sulfatase) 		5 TYR A 300
ALA A  82
ALA A  79
LEU A 403
GLY A 336
 None
 1.18A 5jglB-5fqlA:
undetectable		 5jglB-5fqlA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gwe CYTOCHROME P450

(Corynebacterium
glutamicum) 		PF00067
(p450) 		5 ALA A 409
GLY A 405
LEU A 411
ALA A 413
PRO A 326
 HEM  A 501 (-3.2A)
HEM  A 501 (-3.5A)
None
None
None
 0.90A 5jglB-5gweA:
undetectable		 5jglB-5gweA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hxk ZINC-DEPENDENT
PEPTIDASE

(Thermus
thermophilus) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		5 ALA A  45
ALA A 122
LEU A 123
ALA A  33
GLY A  42
 ALA  A  45 ( 0.0A)
ALA  A 122 ( 0.0A)
LEU  A 123 ( 0.6A)
ALA  A  33 ( 0.0A)
GLY  A  42 ( 0.0A)
 1.30A 5jglB-5hxkA:
undetectable		 5jglB-5hxkA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ic1 TALIN-1

(Mus musculus) 		no annotation 5 ALA A1595
ALA A1444
GLY A1448
SER A1450
PRO A1452
 None
 0.92A 5jglB-5ic1A:
undetectable		 5jglB-5ic1A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iki CYTOCHROME P450(MEG)

(Bacillus
megaterium) 		PF00067
(p450) 		5 ALA A 361
GLY A 357
LEU A 363
ALA A 365
PRO A 278
 HEM  A 501 (-3.5A)
HEM  A 501 (-3.5A)
None
None
None
 0.85A 5jglB-5ikiA:
undetectable		 5jglB-5ikiA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5int PHOSPHOPANTOTHENOYLC
YSTEINE
DECARBOXYLASE

(Bacillus
anthracis) 		PF04127
(DFP) 		5 THR A 237
ALA A 218
ALA A 385
LEU A 389
GLY A 216
 None
 1.08A 5jglB-5intA:
4.3		 5jglB-5intA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5itg SORBITOL
DEHYDROGENASE

(Gluconobacter
oxydans) 		PF01232
(Mannitol_dh)
PF08125
(Mannitol_dh_C) 		5 THR A 388
GLY A 301
LEU A 326
LEU A 311
GLY A 405
 None
 1.45A 5jglB-5itgA:
3.5		 5jglB-5itgA:
20.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jgj UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE

(Aspergillus
fumigatus) 		PF01209
(Ubie_methyltran) 		5 ALA A 138
ALA A 126
GLY A 128
SER A 131
PRO A 133
 None
 1.30A 5jglB-5jgjA:
25.5		 5jglB-5jgjA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjt SERINE/THREONINE-PRO
TEIN PHOSPHATASE 5

(Arabidopsis
thaliana) 		PF00149
(Metallophos)
PF00515
(TPR_1)
PF08321
(PPP5)
PF13431
(TPR_17) 		5 GLY A  88
LEU A 101
ALA A 127
ALA A  93
GLY A  95
 None
 0.86A 5jglB-5jjtA:
undetectable		 5jglB-5jjtA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kei 2,3-DIHYDROXYBENZOAT
E-AMP LIGASE

(Mycolicibacterium
smegmatis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 ALA A  83
GLY A  86
LEU A  76
ALA A 118
GLY A 114
 None
 1.34A 5jglB-5keiA:
undetectable		 5jglB-5keiA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l5w PROTEASOME SUBUNIT
BETA
TYPE-5,PROTEASOME
SUBUNIT BETA TYPE-5

(Saccharomyces
cerevisiae;
Homo sapiens) 		PF00227
(Proteasome) 		5 THR K 125
ALA K  15
LEU K 195
GLY K 156
SER K 159
 None
 1.12A 5jglB-5l5wK:
undetectable		 5jglB-5l5wK:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n28 METHYL-COENZYME M
REDUCTASE SUBUNIT
ALPHA

(Methanotorris
formicicus) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N) 		5 ALA A 115
LEU A 119
ALA A 231
GLY A 235
SER A 237
 None
 1.09A 5jglB-5n28A:
undetectable		 5jglB-5n28A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nbs BETA-GLUCOSIDASE

(Neurospora
crassa) 		no annotation 5 GLY A 515
LEU A  91
GLY A 445
SER A 446
PRO A  90
 None
 1.45A 5jglB-5nbsA:
2.6		 5jglB-5nbsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u1o GLUTATHIONE
REDUCTASE

(Vibrio
parahaemolyticus) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 ALA A 142
GLY A 306
MET A 309
GLY A  20
SER A  23
 FAD  A 501 (-4.4A)
FAD  A 501 (-3.2A)
None
None
None
 1.34A 5jglB-5u1oA:
2.3		 5jglB-5u1oA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u4h UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Acinetobacter
baumannii) 		PF00275
(EPSP_synthase) 		5 ALA A 316
GLY A 357
ALA A 380
LEU A 377
SER A 340
 None
 1.38A 5jglB-5u4hA:
undetectable		 5jglB-5u4hA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uxb MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH

(Brachybacterium
faecium) 		PF01636
(APH) 		5 ALA A 128
GLY A 124
LEU A 130
ALA A 247
GLY A 250
 None
 1.41A 5jglB-5uxbA:
undetectable		 5jglB-5uxbA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v36 GLUTATHIONE
REDUCTASE

(Streptococcus
mutans) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 THR A 170
ALA A 188
GLY A 184
ALA A  60
GLY A 190
 None
None
None
None
EPE  A 526 (-3.8A)
 1.36A 5jglB-5v36A:
undetectable		 5jglB-5v36A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vdn GLUTATHIONE
OXIDOREDUCTASE

(Yersinia pestis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 ALA A 148
GLY A 312
LEU A  18
GLY A  26
SER A  29
 FAD  A 502 (-4.6A)
FAD  A 502 (-3.3A)
None
None
None
 1.44A 5jglB-5vdnA:
undetectable		 5jglB-5vdnA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w7k OXAG

(Penicillium
oxalicum) 		no annotation 6 ALA A  54
GLY A  56
ALA A 110
ALA A 126
SER A 131
PRO A 133
 SAH  A 301 (-3.4A)
SAH  A 301 (-3.4A)
SAH  A 301 (-3.4A)
SAH  A 301 (-3.5A)
SAH  A 301 ( 4.5A)
None
 0.46A 5jglB-5w7kA:
29.8		 5jglB-5w7kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w7k OXAG

(Penicillium
oxalicum) 		no annotation 5 THR A  27
ALA A  54
GLY A  56
ALA A 110
ALA A 126
 SAH  A 301 (-2.9A)
SAH  A 301 (-3.4A)
SAH  A 301 (-3.4A)
SAH  A 301 (-3.4A)
SAH  A 301 (-3.5A)
 0.68A 5jglB-5w7kA:
29.8		 5jglB-5w7kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w7m GLANDICOLINE B
O-METHYLTRANSFERASE
ROQN

(Penicillium
rubens) 		no annotation 6 ALA A  54
GLY A  56
ALA A 110
ALA A 126
SER A 131
PRO A 133
 SAH  A 301 (-3.3A)
SAH  A 301 (-3.3A)
SAH  A 301 (-3.5A)
SAH  A 301 (-3.5A)
SAH  A 301 ( 4.4A)
None
 0.39A 5jglB-5w7mA:
29.8		 5jglB-5w7mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w7m GLANDICOLINE B
O-METHYLTRANSFERASE
ROQN

(Penicillium
rubens) 		no annotation 5 THR A  27
ALA A  54
GLY A  56
ALA A 110
ALA A 126
 SAH  A 301 (-2.9A)
SAH  A 301 (-3.3A)
SAH  A 301 (-3.3A)
SAH  A 301 (-3.5A)
SAH  A 301 (-3.5A)
 0.66A 5jglB-5w7mA:
29.8		 5jglB-5w7mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xjn CYTOCHROME P450

(Corynebacterium
glutamicum) 		PF00067
(p450) 		5 ALA A 382
GLY A 378
LEU A 384
ALA A 386
PRO A 299
 HEM  A 502 (-2.9A)
HEM  A 502 (-3.7A)
None
None
None
 0.90A 5jglB-5xjnA:
undetectable		 5jglB-5xjnA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xk2 DIACYLGLYCEROL
LIPASE

(Aspergillus
oryzae) 		no annotation 5 TYR A  29
ALA A 159
LEU A 161
ALA A  87
GLY A 151
 None
 1.45A 5jglB-5xk2A:
undetectable		 5jglB-5xk2A:
undetectable