SIMILAR PATTERNS OF AMINO ACIDS FOR 5JCN_A_ASCA502_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ixk METHYLTRANSFERASE

(Pyrococcus
horikoshii) 		PF01189
(Methyltr_RsmB-F)
PF17125
(Methyltr_RsmF_N) 		4 GLU A 255
PRO A 282
ARG A 296
ARG A  23
 None
 1.39A 5jcnA-1ixkA:
3.8		 5jcnA-1ixkA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gjn HYPOTHETICAL PROTEIN
PA1024

(Pseudomonas
aeruginosa) 		PF03060
(NMO) 		4 GLU A 155
PRO A 153
ARG A 233
PHE A 147
 None
 1.17A 5jcnA-2gjnA:
0.0		 5jcnA-2gjnA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iik 3-KETOACYL-COA
THIOLASE,
PEROXISOMAL

(Homo sapiens) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 GLU A 394
ARG A 397
PHE A 220
ARG A 386
 None
 1.40A 5jcnA-2iikA:
0.0		 5jcnA-2iikA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o62 HYPOTHETICAL PROTEIN

(Nostoc
punctiforme) 		PF12204
(DUF3598) 		4 GLU A 133
PRO A 215
ARG A 123
PHE A  22
 None
 1.38A 5jcnA-2o62A:
1.0		 5jcnA-2o62A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogj DIHYDROOROTASE

(Agrobacterium
fabrum) 		PF01979
(Amidohydro_1) 		4 GLU A 148
PRO A 147
ARG A 177
ARG A 145
 None
 1.33A 5jcnA-2ogjA:
1.3		 5jcnA-2ogjA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p8t HYPOTHETICAL PROTEIN
PH0730

(Pyrococcus
horikoshii) 		PF14544
(DUF4443) 		4 GLU A  86
PRO A  87
ARG A  77
ARG A  39
 None
 1.22A 5jcnA-2p8tA:
undetectable		 5jcnA-2p8tA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fot 15-O-ACETYLTRANSFERA
SE

(Fusarium
sporotrichioides) 		PF07428
(Tri3) 		4 GLU A  37
ARG A  31
PHE A 353
ARG A 342
 None
 1.30A 5jcnA-3fotA:
0.0		 5jcnA-3fotA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b4d FERREDOXIN-NADP
REDUCTASE

(Xanthomonas
citri) 		PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		4 GLU A 158
PRO A 179
ARG A 154
PHE A 186
 None
 1.22A 5jcnA-4b4dA:
1.9		 5jcnA-4b4dA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jeu SYNTAXIN-BINDING
PROTEIN 1

(Rattus
norvegicus) 		PF00995
(Sec1) 		4 GLU A 246
PRO A 480
ARG A 551
ARG A 467
 None
 1.43A 5jcnA-4jeuA:
0.0		 5jcnA-4jeuA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k17 LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 16A

(Mus musculus) 		PF13516
(LRR_6) 		4 GLU A 411
PRO A 413
ARG A 407
PHE A 404
 None
 1.33A 5jcnA-4k17A:
undetectable		 5jcnA-4k17A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uis GAMMA-SECRETASE

(Homo sapiens) 		PF05450
(Nicastrin) 		4 GLU A 333
PRO A 424
ARG A 281
PHE A 448
 None
 1.46A 5jcnA-4uisA:
undetectable		 5jcnA-4uisA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wj3 ASPARTATE--TRNA(ASP/
ASN) LIGASE

(Pseudomonas
aeruginosa) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon)
PF02938
(GAD) 		4 GLU M 107
PRO M 110
PHE M 129
ARG M 133
 None
 1.16A 5jcnA-4wj3M:
undetectable		 5jcnA-4wj3M:
23.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jcn OS09G0567300 PROTEIN

(Oryza sativa) 		PF07992
(Pyr_redox_2) 		5 GLU A  47
PRO A  49
ARG A 320
PHE A 349
ARG A 351
 None
FAD  A 500 ( 3.6A)
ASC  A 502 (-2.8A)
FAD  A 500 (-3.7A)
ASC  A 502 (-4.0A)
 0.00A 5jcnA-5jcnA:
66.9		 5jcnA-5jcnA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5veh KYNURENINE
AMINOTRANSFERASE

(Aedes aegypti) 		no annotation 4 GLU A  29
PRO A 387
PHE A 391
ARG A 405
 None
 1.45A 5jcnA-5vehA:
0.5		 5jcnA-5vehA:
22.77