SIMILAR PATTERNS OF AMINO ACIDS FOR 5J6H_A_NCAA402

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bg6 N-(1-D-CARBOXYLETHYL
)-L-NORVALINE
DEHYDROGENASE

(Arthrobacter
sp. 1C) 		PF02317
(Octopine_DH)
PF02558
(ApbA) 		3 PRO A 147
ARG A 146
GLU A  42
 None
 0.85A 5j6hA-1bg6A:
0.0		 5j6hA-1bg6A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1biy LACTOFERRIN

(Bubalus bubalis) 		PF00405
(Transferrin) 		3 PRO A 311
ARG A 309
GLU A 682
 None
 0.90A 5j6hA-1biyA:
0.0		 5j6hA-1biyA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bjw ASPARTATE
AMINOTRANSFERASE

(Thermus
thermophilus) 		PF00155
(Aminotran_1_2) 		3 PRO A  91
ARG A  74
GLU A  75
 None
 0.85A 5j6hA-1bjwA:
0.0		 5j6hA-1bjwA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f26 NITRIC OXIDE
REDUCTASE

(Fusarium
oxysporum) 		PF00067
(p450) 		3 PRO A  16
ARG A  12
GLU A  17
 None
 0.86A 5j6hA-1f26A:
undetectable		 5j6hA-1f26A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h79 ANAEROBIC
RIBONUCLEOTIDE-TRIPH
OSPHATE REDUCTASE
LARGE CHAIN

(Escherichia
virus T4) 		PF13597
(NRDD) 		3 PRO A 229
ARG A 264
GLU A 179
 None
 0.99A 5j6hA-1h79A:
0.0		 5j6hA-1h79A:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hcy ARTHROPODAN
HEMOCYANIN

(Panulirus
interruptus) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		3 PRO A 621
ARG A 620
GLU A 627
 None
 0.95A 5j6hA-1hcyA:
2.7		 5j6hA-1hcyA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ii2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE

(Trypanosoma
cruzi) 		PF01293
(PEPCK_ATP) 		3 PRO A  12
ARG A 122
GLU A  13
 None
 0.84A 5j6hA-1ii2A:
0.0		 5j6hA-1ii2A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1im8 YECO

(Haemophilus
influenzae) 		PF13649
(Methyltransf_25) 		3 PRO A 138
ARG A 118
GLU A 140
 None
SAI  A 302 ( 4.5A)
None
 0.97A 5j6hA-1im8A:
0.0		 5j6hA-1im8A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jcm INDOLE-3-GLYCEROL-PH
OSPHATE SYNTHASE

(Escherichia
coli) 		PF00218
(IGPS) 		3 PRO P  34
ARG P 127
GLU P 157
 None
 0.96A 5j6hA-1jcmP:
0.0		 5j6hA-1jcmP:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k4n PROTEIN EC4020

(Escherichia
coli) 		PF06185
(YecM) 		3 PRO A 103
ARG A  79
GLU A 101
 None
 0.98A 5j6hA-1k4nA:
undetectable		 5j6hA-1k4nA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n7g GDP-D-MANNOSE-4,6-DE
HYDRATASE

(Arabidopsis
thaliana) 		PF16363
(GDP_Man_Dehyd) 		3 PRO A 218
ARG A 227
GLU A 350
 None
 0.93A 5j6hA-1n7gA:
undetectable		 5j6hA-1n7gA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o4s ASPARTATE
AMINOTRANSFERASE

(Thermotoga
maritima) 		PF00155
(Aminotran_1_2) 		3 PRO A  89
ARG A  72
GLU A  73
 None
 0.67A 5j6hA-1o4sA:
undetectable		 5j6hA-1o4sA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q2e EXOCELLOBIOHYDROLASE
I

(Trichoderma
reesei) 		PF00840
(Glyco_hydro_7) 		3 PRO A 382
ARG A 394
GLU A 385
 None
SGC  A 902 ( 3.5A)
MGL  A 901 ( 4.9A)
 0.95A 5j6hA-1q2eA:
undetectable		 5j6hA-1q2eA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Escherichia
coli) 		PF00311
(PEPcase) 		3 PRO A 196
ARG A 195
GLU A 201
 None
 0.70A 5j6hA-1qb4A:
undetectable		 5j6hA-1qb4A:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ued P450 MONOOXYGENASE

(Amycolatopsis
orientalis) 		PF00067
(p450) 		3 PRO A 334
ARG A 326
GLU A 328
 None
 0.97A 5j6hA-1uedA:
undetectable		 5j6hA-1uedA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v2d GLUTAMINE
AMINOTRANSFERASE

(Thermus
thermophilus) 		PF00155
(Aminotran_1_2) 		3 PRO A  78
ARG A  67
GLU A  68
 None
 0.82A 5j6hA-1v2dA:
undetectable		 5j6hA-1v2dA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v63 NUCLEOLAR
TRANSCRIPTION FACTOR
1

(Mus musculus) 		PF09011
(HMG_box_2) 		3 PRO A  33
ARG A  37
GLU A  36
 None
 0.97A 5j6hA-1v63A:
undetectable		 5j6hA-1v63A:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vzv VARICELLA-ZOSTER
VIRUS PROTEASE

(Human
alphaherpesvirus
3) 		PF00716
(Peptidase_S21) 		3 PRO A 104
ARG A 107
GLU A 106
 None
 0.92A 5j6hA-1vzvA:
undetectable		 5j6hA-1vzvA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z66 MAJOR ENVELOPE
PROTEIN E

(Langat virus) 		PF02832
(Flavi_glycop_C) 		3 PRO A 337
ARG A 339
GLU A 365
 None
 0.81A 5j6hA-1z66A:
4.7		 5j6hA-1z66A:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zq1 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT E

(Pyrococcus
abyssi) 		PF02637
(GatB_Yqey)
PF02934
(GatB_N)
PF02938
(GAD) 		3 PRO C 279
ARG C 401
GLU C 405
 None
 0.85A 5j6hA-1zq1C:
undetectable		 5j6hA-1zq1C:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aex COPROPORPHYRINOGEN
III OXIDASE,
MITOCHONDRIAL

(Homo sapiens) 		PF01218
(Coprogen_oxidas) 		3 PRO A 134
ARG A 180
GLU A 153
 None
 1.00A 5j6hA-2aexA:
undetectable		 5j6hA-2aexA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b3a RAL GUANINE
NUCLEOTIDE
DISSOCIATION
STIMULATOR

(Homo sapiens) 		PF00788
(RA) 		3 PRO A  39
ARG A  43
GLU A  75
 None
 0.84A 5j6hA-2b3aA:
undetectable		 5j6hA-2b3aA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dfe RIBONUCLEASE HII

(Thermococcus
kodakarensis) 		PF01351
(RNase_HII) 		3 PRO A  17
ARG A 152
GLU A  67
 None
 0.99A 5j6hA-2dfeA:
undetectable		 5j6hA-2dfeA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ecf DIPEPTIDYL PEPTIDASE
IV

(Stenotrophomonas
maltophilia) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		3 PRO A 486
ARG A 485
GLU A 488
 None
 1.00A 5j6hA-2ecfA:
undetectable		 5j6hA-2ecfA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fyi HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CBL

(Escherichia
coli) 		PF03466
(LysR_substrate) 		3 PRO A 131
ARG A 151
GLU A 150
 None
 0.97A 5j6hA-2fyiA:
undetectable		 5j6hA-2fyiA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gb3 ASPARTATE
AMINOTRANSFERASE

(Thermotoga
maritima) 		PF00155
(Aminotran_1_2) 		3 PRO A  90
ARG A  73
GLU A  74
 None
 0.71A 5j6hA-2gb3A:
undetectable		 5j6hA-2gb3A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		3 PRO A 462
ARG A 460
GLU A 454
 None
 0.99A 5j6hA-2h8hA:
undetectable		 5j6hA-2h8hA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jls SERINE PROTEASE
SUBUNIT NS3

(Dengue virus) 		PF07652
(Flavi_DEAD) 		3 PRO A 511
ARG A 513
GLU A 512
 None
 0.91A 5j6hA-2jlsA:
undetectable		 5j6hA-2jlsA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o21 APOPTOSIS REGULATOR
BCL-2

(Homo sapiens) 		PF00452
(Bcl-2)
PF02180
(BH4) 		3 PRO A  42
ARG A  38
GLU A  43
 None
 0.95A 5j6hA-2o21A:
undetectable		 5j6hA-2o21A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rfb CYTOCHROME P450

(Picrophilus
torridus) 		PF00067
(p450) 		3 PRO A 283
ARG A 275
GLU A 277
 None
 0.91A 5j6hA-2rfbA:
undetectable		 5j6hA-2rfbA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v6j RNA HELICASE

(Kokobera virus) 		PF00271
(Helicase_C)
PF07652
(Flavi_DEAD) 		3 PRO A 324
ARG A 326
GLU A 325
 None
 0.85A 5j6hA-2v6jA:
undetectable		 5j6hA-2v6jA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vz9 FATTY ACID SYNTHASE

(Sus scrofa) 		PF00107
(ADH_zinc_N)
PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF08242
(Methyltransf_12)
PF08659
(KR)
PF14765
(PS-DH)
PF16197
(KAsynt_C_assoc) 		3 PRO A1043
ARG A1084
GLU A1016
 None
 0.96A 5j6hA-2vz9A:
undetectable		 5j6hA-2vz9A:
8.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2wy3 MHC CLASS I
POLYPEPTIDE-RELATED
SEQUENCE B

(Homo sapiens) 		PF00129
(MHC_I) 		3 PRO A  45
ARG A  35
GLU A  51
 None
ACT  A1177 (-4.0A)
None
 0.67A 5j6hA-2wy3A:
16.6		 5j6hA-2wy3A:
31.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x0s PYRUVATE PHOSPHATE
DIKINASE

(Trypanosoma
brucei) 		PF00391
(PEP-utilizers)
PF01326
(PPDK_N)
PF02896
(PEP-utilizers_C) 		3 PRO A 646
ARG A 690
GLU A 588
 None
 0.98A 5j6hA-2x0sA:
undetectable		 5j6hA-2x0sA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xj9 MIPZ

(Caulobacter
vibrioides) 		PF09140
(MipZ) 		3 PRO A  85
ARG A  84
GLU A  87
 None
 0.73A 5j6hA-2xj9A:
undetectable		 5j6hA-2xj9A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yiu CYTOCHROME C1, HEME
PROTEIN

(Paracoccus
denitrificans) 		PF02167
(Cytochrom_C1) 		3 PRO B 121
ARG B 127
GLU B 122
 None
 0.82A 5j6hA-2yiuB:
undetectable		 5j6hA-2yiuB:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z61 PROBABLE ASPARTATE
AMINOTRANSFERASE 2

(Methanocaldococcus
jannaschii) 		PF00155
(Aminotran_1_2) 		3 PRO A  89
ARG A  72
GLU A  73
 None
 0.89A 5j6hA-2z61A:
undetectable		 5j6hA-2z61A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z83 HELICASE/NUCLEOSIDE
TRIPHOSPHATASE

(Japanese
encephalitis
virus) 		PF00271
(Helicase_C)
PF07652
(Flavi_DEAD) 		3 PRO A 512
ARG A 514
GLU A 513
 None
 0.98A 5j6hA-2z83A:
undetectable		 5j6hA-2z83A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ddc RAS ASSOCIATION
DOMAIN-CONTAINING
FAMILY PROTEIN 5

(Mus musculus) 		PF00788
(RA) 		3 PRO B 345
ARG B 340
GLU B 217
 None
 0.79A 5j6hA-3ddcB:
undetectable		 5j6hA-3ddcB:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f8t PREDICTED ATPASE
INVOLVED IN
REPLICATION CONTROL,
CDC46/MCM FAMILY

(Methanopyrus
kandleri) 		PF00493
(MCM) 		3 PRO A 473
ARG A 422
GLU A 418
 None
 0.86A 5j6hA-3f8tA:
undetectable		 5j6hA-3f8tA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gpr RHODOCETIN SUBUNIT
GAMMA

(Calloselasma
rhodostoma) 		PF00059
(Lectin_C) 		3 PRO C3064
ARG C3109
GLU C3065
 None
 0.96A 5j6hA-3gprC:
undetectable		 5j6hA-3gprC:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhs PHENOLOXIDASE
SUBUNIT 2

(Manduca sexta) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		3 PRO A 381
ARG A 305
GLU A 382
 None
 0.97A 5j6hA-3hhsA:
2.0		 5j6hA-3hhsA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hi8 PROLIFERATING CELL
NUCLEAR ANTIGEN PCNA

(Haloferax
volcanii) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		3 PRO A 242
ARG A 243
GLU A 220
 None
 0.88A 5j6hA-3hi8A:
undetectable		 5j6hA-3hi8A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihj ALANINE
AMINOTRANSFERASE 2

(Homo sapiens) 		PF00155
(Aminotran_1_2) 		3 PRO A 178
ARG A 160
GLU A 161
 None
 0.97A 5j6hA-3ihjA:
undetectable		 5j6hA-3ihjA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ivf TALIN-1

(Mus musculus) 		PF00373
(FERM_M)
PF02174
(IRS)
PF09379
(FERM_N)
PF16511
(FERM_f0) 		3 PRO A 327
ARG A 328
GLU A 342
 None
 0.90A 5j6hA-3ivfA:
undetectable		 5j6hA-3ivfA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j8f POLIOVIRUS RECEPTOR

(Homo sapiens) 		PF07686
(V-set)
PF08205
(C2-set_2) 		3 PRO 7 173
ARG 7 172
GLU 7 226
 None
 0.96A 5j6hA-3j8f7:
9.3		 5j6hA-3j8f7:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j9f POLIOVIRUS RECEPTOR

(Homo sapiens) 		PF08205
(C2-set_2) 		3 PRO 8 173
ARG 8 172
GLU 8 226
 None
 0.89A 5j6hA-3j9f8:
9.3		 5j6hA-3j9f8:
17.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3jts MHC CLASS I
MAMU-A*02

(Macaca mulatta) 		PF00129
(MHC_I)
PF07654
(C1-set) 		3 PRO A  47
ARG A  48
GLU A  53
 None
 0.99A 5j6hA-3jtsA:
32.7		 5j6hA-3jtsA:
76.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ksm ABC-TYPE SUGAR
TRANSPORT SYSTEM,
PERIPLASMIC
COMPONENT

(Hahella
chejuensis) 		PF13407
(Peripla_BP_4) 		3 PRO A 232
ARG A 183
GLU A 184
 None
BDR  A   1 (-3.2A)
None
 0.82A 5j6hA-3ksmA:
undetectable		 5j6hA-3ksmA:
21.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kyo MHC CLASS I ANTIGEN

(Homo sapiens) 		PF00129
(MHC_I)
PF07654
(C1-set) 		3 PRO A  47
ARG A  48
GLU A  53
 None
 0.68A 5j6hA-3kyoA:
33.3		 5j6hA-3kyoA:
72.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mga ENTEROCHELIN
ESTERASE

(Salmonella
enterica) 		PF00756
(Esterase)
PF11806
(DUF3327) 		3 PRO A 272
ARG A 199
GLU A 197
 None
 0.90A 5j6hA-3mgaA:
undetectable		 5j6hA-3mgaA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3njp EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain)
PF14843
(GF_recep_IV) 		3 PRO A 112
ARG A 114
GLU A 110
 None
 0.92A 5j6hA-3njpA:
undetectable		 5j6hA-3njpA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o0h GLUTATHIONE
REDUCTASE

(Bartonella
henselae) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		3 PRO A 385
ARG A 375
GLU A 386
 None
 0.98A 5j6hA-3o0hA:
undetectable		 5j6hA-3o0hA:
21.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pwv MHC CLASS I ANTIGEN

(Bos taurus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		3 PRO A  46
ARG A  47
GLU A  52
 None
 0.74A 5j6hA-3pwvA:
34.0		 5j6hA-3pwvA:
74.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qr1 PHOSPHOLIPASE C-BETA
(PLC-BETA)

(Doryteuthis
pealeii) 		PF00168
(C2)
PF00387
(PI-PLC-Y)
PF00388
(PI-PLC-X)
PF09279
(EF-hand_like) 		3 PRO A 749
ARG A 751
GLU A 154
 None
 0.93A 5j6hA-3qr1A:
undetectable		 5j6hA-3qr1A:
16.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3rwg MAJOR
HISTOCOMPATIBILITY
COMPLEX CLASS I

(Macaca mulatta) 		PF00129
(MHC_I)
PF07654
(C1-set) 		3 PRO A  47
ARG A  48
GLU A  53
 None
 0.43A 5j6hA-3rwgA:
33.7		 5j6hA-3rwgA:
76.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3udb SERINE/THREONINE-PRO
TEIN KINASE SRK2E

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		3 PRO A 220
ARG A 232
GLU A 221
 None
 0.90A 5j6hA-3udbA:
undetectable		 5j6hA-3udbA:
23.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vj6 H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN, D-37 ALPHA
CHAIN

(Mus musculus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		3 PRO A  47
ARG A  48
GLU A  53
 None
 0.56A 5j6hA-3vj6A:
34.2		 5j6hA-3vj6A:
78.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zoq URACIL-DNA
GLYCOSYLASE

(Bacillus
subtilis) 		PF03167
(UDG) 		3 PRO A 202
ARG A 205
GLU A  96
 None
 0.74A 5j6hA-3zoqA:
undetectable		 5j6hA-3zoqA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zxs CRYPTOCHROME B

(Rhodobacter
sphaeroides) 		PF04244
(DPRP) 		3 PRO A 189
ARG A 244
GLU A 240
 None
 0.97A 5j6hA-3zxsA:
undetectable		 5j6hA-3zxsA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e5k PHOSPHITE
DEHYDROGENASE
(THERMOSTABLE
VARIANT)

(Pseudomonas
stutzeri) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		3 PRO A  66
ARG A  44
GLU A  67
 None
 0.90A 5j6hA-4e5kA:
undetectable		 5j6hA-4e5kA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4emo SHARPIN

(Homo sapiens) 		PF16764
(Sharpin_PH) 		3 PRO A  50
ARG A  57
GLU A  51
 None
 0.96A 5j6hA-4emoA:
undetectable		 5j6hA-4emoA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f32 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Burkholderia
vietnamiensis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		3 PRO A  66
ARG A  68
GLU A  67
 None
 0.97A 5j6hA-4f32A:
undetectable		 5j6hA-4f32A:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fxt UNCHARACTERIZED
PROTEIN

(Bacteroides
ovatus) 		PF12866
(DUF3823) 		3 PRO A  93
ARG A  96
GLU A 212
 None
 0.94A 5j6hA-4fxtA:
3.6		 5j6hA-4fxtA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gh4 CAPSID PROTEIN VP1
CAPSID PROTEIN VP2

(Foot-and-mouth
disease virus;
Foot-and-mouth
disease virus) 		PF00073
(Rhv)
PF00073
(Rhv) 		3 PRO A 189
ARG A 188
GLU B 136
 None
 0.95A 5j6hA-4gh4A:
undetectable		 5j6hA-4gh4A:
22.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lcy HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-46 ALPHA
CHAIN

(Homo sapiens) 		PF00129
(MHC_I)
PF07654
(C1-set) 		3 PRO A  47
ARG A  48
GLU A  53
 None
 0.59A 5j6hA-4lcyA:
33.5		 5j6hA-4lcyA:
76.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mif PYRANOSE 2-OXIDASE

(Phanerochaete
chrysosporium) 		PF05199
(GMC_oxred_C) 		3 PRO A 180
ARG A 177
GLU A 590
 None
 1.00A 5j6hA-4mifA:
undetectable		 5j6hA-4mifA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mjg HYPOTHETICAL PROTEIN

(Actinomyces
odontolyticus) 		PF16145
(DUF4853) 		3 PRO A  40
ARG A  42
GLU A  41
 None
SO4  A 301 (-3.5A)
None
 0.83A 5j6hA-4mjgA:
undetectable		 5j6hA-4mjgA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o6i NUCLEOPROTEIN

(Lymphocytic
choriomeningitis
mammarenavirus) 		PF17290
(Arena_ncap_C) 		3 PRO A 535
ARG A 533
GLU A 527
 None
None
IMD  A 606 (-3.2A)
 0.76A 5j6hA-4o6iA:
undetectable		 5j6hA-4o6iA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qvh MALTOSE-BINDING
PERIPLASMIC PROTEIN,
4'-PHOSPHOPANTETHEIN
YL TRANSFERASE
CHIMERA

(Escherichia
coli;
Mycobacterium
tuberculosis) 		PF01648
(ACPS)
PF13416
(SBP_bac_8) 		3 PRO A 443
ARG A 431
GLU A 407
 None
 1.00A 5j6hA-4qvhA:
undetectable		 5j6hA-4qvhA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r0v FE-HYDROGENASE

(Chlamydomonas
reinhardtii) 		PF02256
(Fe_hyd_SSU)
PF02906
(Fe_hyd_lg_C) 		3 PRO A 428
ARG A 429
GLU A 101
 None
 0.94A 5j6hA-4r0vA:
undetectable		 5j6hA-4r0vA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rm4 CYTOCHROME P450

(Bacillus
subtilis) 		PF00067
(p450) 		3 PRO A 327
ARG A 319
GLU A 321
 None
 0.74A 5j6hA-4rm4A:
undetectable		 5j6hA-4rm4A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wrw URACIL-DNA
GLYCOSYLASE

(Mycobacterium
tuberculosis) 		PF03167
(UDG) 		3 PRO A 206
ARG A 209
GLU A 100
 None
 0.66A 5j6hA-4wrwA:
undetectable		 5j6hA-4wrwA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x8y MEMBRANE-ASSOCIATED
PROGESTERONE
RECEPTOR COMPONENT 1

(Homo sapiens) 		PF00173
(Cyt-b5) 		3 PRO A 109
ARG A 104
GLU A 110
 None
 0.94A 5j6hA-4x8yA:
undetectable		 5j6hA-4x8yA:
19.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4zut CLASSICAL MHC CLASS
I ANTIGEN

(Equus caballus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		3 PRO A  47
ARG A  48
GLU A  53
 None
 0.42A 5j6hA-4zutA:
33.2		 5j6hA-4zutA:
75.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5anb ELONGATION FACTOR TU
GTP-BINDING
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF14492
(EFG_II) 		3 PRO K 691
ARG K 693
GLU K 885
 None
 0.85A 5j6hA-5anbK:
undetectable		 5j6hA-5anbK:
14.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f1n MHC CLASS I ANTIGEN

(Canis lupus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		3 PRO A  47
ARG A  48
GLU A  53
 None
 1.00A 5j6hA-5f1nA:
33.2		 5j6hA-5f1nA:
73.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fjn L-AMINO ACID
DEAMINASE

(Cosenzaea
myxofaciens) 		PF01266
(DAO) 		3 PRO A 466
ARG A 471
GLU A 109
 None
 0.72A 5j6hA-5fjnA:
undetectable		 5j6hA-5fjnA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5flv HOMEOBOX PROTEIN
NKX-2.5, T-BOX
TRANSCRIPTION FACTOR
TBX5

(Mus musculus) 		PF00046
(Homeobox)
PF00907
(T-box) 		3 PRO A 165
ARG A 167
GLU A 166
 None
 0.83A 5j6hA-5flvA:
undetectable		 5j6hA-5flvA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h2v IMPORTIN SUBUNIT
BETA-3

(Saccharomyces
cerevisiae) 		PF13513
(HEAT_EZ) 		3 PRO A 279
ARG A 282
GLU A 278
 None
 0.89A 5j6hA-5h2vA:
undetectable		 5j6hA-5h2vA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hxw L-AMINO ACID
DEAMINASE

(Proteus
vulgaris) 		PF01266
(DAO) 		3 PRO A 465
ARG A 470
GLU A 108
 None
 0.79A 5j6hA-5hxwA:
undetectable		 5j6hA-5hxwA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i39 L-AMINO ACID
DEAMINASE

(Proteus
vulgaris) 		PF01266
(DAO) 		3 PRO A 465
ARG A 470
GLU A 108
 None
 0.86A 5j6hA-5i39A:
undetectable		 5j6hA-5i39A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jfc NADH-DEPENDENT
FERREDOXIN:NADP
OXIDOREDUCTASE
SUBUNIT ALPHA

(Pyrococcus
furiosus) 		PF07992
(Pyr_redox_2)
PF14691
(Fer4_20) 		3 PRO L 119
ARG L   8
GLU L 108
 None
 0.84A 5j6hA-5jfcL:
undetectable		 5j6hA-5jfcL:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjq AMP-DEPENDENT
SYNTHETASE AND
LIGASE

(Streptomyces
sp. ML694-90F3) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		3 PRO A 162
ARG A 186
GLU A  14
 None
 0.97A 5j6hA-5jjqA:
undetectable		 5j6hA-5jjqA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oj2 MAM
DOMAIN-CONTAINING
GLYCOSYLPHOSPHATIDYL
INOSITOL ANCHOR
PROTEIN 1

(Gallus gallus) 		PF13927
(Ig_3) 		3 PRO A 525
ARG A 524
GLU A 527
 None
 0.86A 5j6hA-5oj2A:
5.0		 5j6hA-5oj2A:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oom 39S RIBOSOMAL
PROTEIN L47,
MITOCHONDRIAL

(Homo sapiens) 		PF06984
(MRP-L47) 		3 PRO Y 129
ARG Y 131
GLU Y 130
 None
 0.99A 5j6hA-5oomY:
undetectable		 5j6hA-5oomY:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5osn CAPSID PROTEIN
CAPSID PROTEIN

(Enterovirus E;
Enterovirus E) 		PF00073
(Rhv)
PF00073
(Rhv) 		3 PRO B 211
ARG C  68
GLU B 213
 None
 0.95A 5j6hA-5osnB:
undetectable		 5j6hA-5osnB:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5thh TYROSINE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		PF00579
(tRNA-synt_1b) 		3 PRO A  86
ARG A  93
GLU A  88
 None
 0.91A 5j6hA-5thhA:
undetectable		 5j6hA-5thhA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u9c DTDP-4-DEHYDRORHAMNO
SE REDUCTASE

(Yersinia
enterocolitica) 		PF04321
(RmlD_sub_bind) 		3 PRO A 254
ARG A 186
GLU A 257
 None
 0.93A 5j6hA-5u9cA:
undetectable		 5j6hA-5u9cA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uhu MYCINAMICIN IV
HYDROXYLASE/EPOXIDAS
E

(Micromonospora
griseorubida) 		PF00067
(p450) 		3 PRO A 287
ARG A 288
GLU A  71
 None
HEM  A 401 (-3.0A)
None
 0.94A 5j6hA-5uhuA:
undetectable		 5j6hA-5uhuA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ulm MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5

(Homo sapiens) 		PF13281
(DUF4071) 		3 PRO A 560
ARG A 558
GLU A 548
 None
 0.75A 5j6hA-5ulmA:
undetectable		 5j6hA-5ulmA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vol PUTATIVE ESTERASE

(Bacteroides
intestinalis) 		PF00756
(Esterase) 		3 PRO A 279
ARG A 283
GLU A  91
 None
 0.96A 5j6hA-5volA:
undetectable		 5j6hA-5volA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wi8 TUMOR NECROSIS
FACTOR RECEPTOR
SUPERFAMILY MEMBER 9

(Mus musculus) 		no annotation 3 PRO A 107
ARG A 106
GLU A 153
 None
 0.97A 5j6hA-5wi8A:
undetectable		 5j6hA-5wi8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wml -

(-) 		no annotation 3 PRO A 159
ARG A 142
GLU A 143
 None
 0.87A 5j6hA-5wmlA:
undetectable		 5j6hA-5wmlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xix ASPARAGINE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		no annotation 3 PRO A 453
ARG A 451
GLU A 460
 None
 0.98A 5j6hA-5xixA:
undetectable		 5j6hA-5xixA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xmm MHC CLASS I ANTIGEN
ALPHA CHAIN

(Felis catus) 		no annotation 3 PRO A  48
ARG A  49
GLU A  54
 None
 0.91A 5j6hA-5xmmA:
33.4		 5j6hA-5xmmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zgb LHCR2

(Cyanidioschyzon
merolae) 		no annotation 3 PRO 2 135
ARG 2 133
GLU 2  53
 None
 0.70A 5j6hA-5zgb2:
undetectable		 5j6hA-5zgb2:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bk1 UDP-GLYCOSYLTRANSFER
ASE 79

(Oryza sativa) 		no annotation 3 PRO A 124
ARG A 128
GLU A 205
 None
 0.83A 5j6hA-6bk1A:
undetectable		 5j6hA-6bk1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c0f PROTEASOME-INTERACTI
NG PROTEIN CIC1

(Saccharomyces
cerevisiae) 		no annotation 3 PRO K 256
ARG K 255
GLU K 257
 None
 0.95A 5j6hA-6c0fK:
undetectable		 5j6hA-6c0fK:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f0k FE-S-CLUSTER-CONTAIN
ING HYDROGENASE
ACTH

(Rhodothermus
marinus;
Rhodothermus
marinus) 		no annotation
no annotation 		3 PRO B  96
ARG H 149
GLU B 115
 None
 0.99A 5j6hA-6f0kB:
undetectable		 5j6hA-6f0kB:
undetectable