SIMILAR PATTERNS OF AMINO ACIDS FOR 5J4N_B_AG2B501_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bg6 N-(1-D-CARBOXYLETHYL
)-L-NORVALINE
DEHYDROGENASE

(Arthrobacter
sp. 1C) 		PF02317
(Octopine_DH)
PF02558
(ApbA) 		4 ILE A  50
GLY A  15
ASN A  14
ILE A  49
 None
 0.98A 5j4nB-1bg6A:
0.0		 5j4nB-1bg6A:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bh6 SUBTILISIN DY

(Bacillus
licheniformis) 		PF00082
(Peptidase_S8) 		4 ILE A  93
GLY A  63
ASN A  62
ILE A  30
 None
None
1BH  A 300 ( 4.6A)
None
 0.89A 5j4nB-1bh6A:
0.0		 5j4nB-1bh6A:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cij PROTEIN (HALOALKANE
DEHALOGENASE)

(Xanthobacter
autotrophicus) 		PF00561
(Abhydrolase_1) 		4 ILE A 118
GLY A  42
ASN A  43
ILE A  78
 None
 0.87A 5j4nB-1cijA:
0.0		 5j4nB-1cijA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dbr HYPOXANTHINE GUANINE
XANTHINE
PHOSPHORIBOSYLTRANSF
ERASE

(Toxoplasma
gondii) 		PF00156
(Pribosyltran) 		4 ILE A  75
GLY A  83
ASN A  86
ILE A  77
 None
 0.98A 5j4nB-1dbrA:
0.0		 5j4nB-1dbrA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dj3 ADENYLOSUCCINATE
SYNTHETASE

(Triticum
aestivum) 		PF00709
(Adenylsucc_synt) 		4 ILE A 229
GLY A  87
ASN A  88
ILE A 235
 None
 0.92A 5j4nB-1dj3A:
0.0		 5j4nB-1dj3A:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eiz FTSJ

(Escherichia
coli) 		PF01728
(FtsJ) 		4 ILE A  80
GLY A  63
MET A  87
ILE A  79
 None
SAM  A 301 (-3.9A)
None
None
 0.88A 5j4nB-1eizA:
undetectable		 5j4nB-1eizA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eo1 HYPOTHETICAL PROTEIN
MTH1175

(Methanothermobacter
thermautotrophicus) 		PF02579
(Nitro_FeMo-Co) 		4 ILE A  28
GLY A  34
ASN A  35
ILE A   3
 None
 0.83A 5j4nB-1eo1A:
undetectable		 5j4nB-1eo1A:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gec GLYCYL ENDOPEPTIDASE

(Carica papaya) 		PF00112
(Peptidase_C1) 		4 ILE E 148
GLY E 202
ASN E 199
ILE E 193
 None
 1.00A 5j4nB-1gecE:
0.0		 5j4nB-1gecE:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ghs 1,3-BETA-GLUCANASE

(Hordeum vulgare) 		PF00332
(Glyco_hydro_17) 		4 ILE A 304
GLY A  29
ASN A  28
ILE A 273
 None
 1.00A 5j4nB-1ghsA:
0.0		 5j4nB-1ghsA:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gl6 ATPASE

(Escherichia
coli) 		PF10412
(TrwB_AAD_bind) 		4 GLY A 161
ASN A 160
ILE A 315
TRP A 317
 None
 0.91A 5j4nB-1gl6A:
0.2		 5j4nB-1gl6A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i31 CLATHRIN COAT
ASSEMBLY PROTEIN
AP50

(Rattus
norvegicus) 		PF00928
(Adap_comp_sub) 		4 ILE A 307
GLY A 189
MET A 185
ILE A 290
 None
 0.95A 5j4nB-1i31A:
undetectable		 5j4nB-1i31A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m0d ENDODEOXYRIBONUCLEAS
E I

(Escherichia
virus T7) 		PF05367
(Phage_endo_I) 		4 ILE A  92
GLY A  61
ASN A  60
ILE A  90
 None
 0.96A 5j4nB-1m0dA:
undetectable		 5j4nB-1m0dA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u8x MALTOSE-6'-PHOSPHATE
GLUCOSIDASE

(Bacillus
subtilis) 		PF02056
(Glyco_hydro_4)
PF11975
(Glyco_hydro_4C) 		4 ILE X 170
GLY X 204
ASN X 263
ILE X 342
 None
 1.00A 5j4nB-1u8xX:
undetectable		 5j4nB-1u8xX:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v4p ALANYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		no annotation 4 ILE A  43
GLY A  17
ASN A 112
ILE A 146
 None
 0.84A 5j4nB-1v4pA:
undetectable		 5j4nB-1v4pA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w61 B-CELL MITOGEN

(Trypanosoma
cruzi) 		PF05544
(Pro_racemase) 		4 ILE A 135
GLY A 216
ASN A 218
ILE A 365
 None
 0.84A 5j4nB-1w61A:
undetectable		 5j4nB-1w61A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xp3 ENDONUCLEASE IV

(Bacillus
anthracis) 		PF01261
(AP_endonuc_2) 		4 ILE A  67
GLY A  54
MET A  58
ILE A  33
 None
 0.96A 5j4nB-1xp3A:
undetectable		 5j4nB-1xp3A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y6u EXCISIONASE FROM
TRANSPOSON TN916

(Enterococcus
faecalis) 		PF09035
(Tn916-Xis) 		4 ILE A  52
GLY A  47
ASN A  48
ILE A  44
 None
 1.00A 5j4nB-1y6uA:
undetectable		 5j4nB-1y6uA:
9.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ani RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA SUBUNIT

(Chlamydia
trachomatis) 		PF00268
(Ribonuc_red_sm) 		4 ILE A 241
GLY A 304
ILE A 238
TRP A 249
 None
 1.00A 5j4nB-2aniA:
undetectable		 5j4nB-2aniA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2azp HYPOTHETICAL PROTEIN
PA1268

(Pseudomonas
aeruginosa) 		PF05544
(Pro_racemase) 		4 ILE A  93
GLY A 160
ASN A 162
ILE A 288
 None
 0.91A 5j4nB-2azpA:
undetectable		 5j4nB-2azpA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fek LOW MOLECULAR WEIGHT
PROTEIN-TYROSINE-PHO
SPHATASE WZB

(Escherichia
coli) 		PF01451
(LMWPc) 		4 ILE A   5
GLY A  36
ASN A  12
ILE A  79
 None
 0.92A 5j4nB-2fekA:
undetectable		 5j4nB-2fekA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fqx MEMBRANE LIPOPROTEIN
TMPC

(Treponema
pallidum) 		PF02608
(Bmp) 		4 ILE A 235
GLY A 217
ASN A 216
ILE A 207
 None
 0.86A 5j4nB-2fqxA:
undetectable		 5j4nB-2fqxA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gpr GLUCOSE-PERMEASE IIA
COMPONENT

(Mycoplasma
capricolum) 		PF00358
(PTS_EIIA_1) 		4 ILE A 127
GLY A  93
ASN A  94
ILE A  84
 None
 0.87A 5j4nB-2gprA:
undetectable		 5j4nB-2gprA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ji9 OXALYL-COA
DECARBOXYLASE

(Oxalobacter
formigenes) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 ILE A 475
GLY A 459
MET A 432
ILE A 476
 None
 0.89A 5j4nB-2ji9A:
undetectable		 5j4nB-2ji9A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oaj PROTEIN SNI1

(Saccharomyces
cerevisiae) 		PF08596
(Lgl_C) 		4 ILE A 164
GLY A 180
ASN A 179
ILE A 217
 None
 0.95A 5j4nB-2oajA:
undetectable		 5j4nB-2oajA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q1y CELL DIVISION
PROTEIN FTSZ

(Mycobacterium
tuberculosis) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		4 ILE A  38
GLY A  19
ASN A  22
ILE A  16
 None
GSP  A 401 (-3.6A)
GSP  A 401 (-3.8A)
None
 0.97A 5j4nB-2q1yA:
undetectable		 5j4nB-2q1yA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qc5 STREPTOGRAMIN B
LACTONASE

(Staphylococcus
cohnii) 		no annotation 4 ILE A 272
GLY A 191
ASN A 192
ILE A 230
 ILE  A 272 ( 0.7A)
GLY  A 191 ( 0.0A)
ASN  A 192 ( 0.6A)
ILE  A 230 ( 0.6A)
 0.96A 5j4nB-2qc5A:
undetectable		 5j4nB-2qc5A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qr6 IMP
DEHYDROGENASE/GMP
REDUCTASE

(Corynebacterium
glutamicum) 		PF00478
(IMPDH) 		4 ILE A 217
GLY A 265
MET A 236
ILE A 218
 None
 0.97A 5j4nB-2qr6A:
undetectable		 5j4nB-2qr6A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r2d ZN-DEPENDENT
HYDROLASES

(Agrobacterium
fabrum) 		PF00753
(Lactamase_B) 		4 ILE A 156
GLY A  70
ASN A  69
ILE A 152
 None
 0.95A 5j4nB-2r2dA:
undetectable		 5j4nB-2r2dA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w8q SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00171
(Aldedh) 		4 ILE A 141
GLY A 373
ASN A 372
ILE A 142
 None
 0.95A 5j4nB-2w8qA:
undetectable		 5j4nB-2w8qA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x5f ASPARTATE_TYROSINE_P
HENYLALANINE
PYRIDOXAL-5'
PHOSPHATE-DEPENDENT
AMINOTRANSFERASE

(Staphylococcus
aureus) 		PF00155
(Aminotran_1_2) 		4 ILE A 401
GLY A 201
ASN A 197
ILE A 403
 None
 1.00A 5j4nB-2x5fA:
undetectable		 5j4nB-2x5fA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yhf C-TYPE LECTIN DOMAIN
FAMILY 5 MEMBER A

(Homo sapiens) 		PF00059
(Lectin_C) 		4 ILE A 143
GLY A 150
ASN A 149
TRP A 142
 None
 1.00A 5j4nB-2yhfA:
undetectable		 5j4nB-2yhfA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2n VIRGINIAMYCIN B
LYASE

(Staphylococcus
aureus) 		no annotation 4 ILE A 272
GLY A 191
ASN A 192
ILE A 230
 None
 0.97A 5j4nB-2z2nA:
undetectable		 5j4nB-2z2nA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ada SARCOSINE OXIDASE
BETA SUBUNIT

(Corynebacterium
sp. U-96) 		PF01266
(DAO) 		4 ILE B 147
GLY B 151
ASN B 153
ILE B 148
 None
 0.95A 5j4nB-3adaB:
undetectable		 5j4nB-3adaB:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c97 SIGNAL TRANSDUCTION
HISTIDINE KINASE

(Aspergillus
oryzae) 		PF00072
(Response_reg) 		4 ILE A 601
GLY A 585
MET A 606
ILE A 600
 None
 0.97A 5j4nB-3c97A:
undetectable		 5j4nB-3c97A:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE ALPHA SUBUNIT

(Methanosarcina
barkeri) 		PF03063
(Prismane) 		4 ILE A 517
GLY A 644
ASN A 646
ILE A 593
 None
 0.91A 5j4nB-3cf4A:
undetectable		 5j4nB-3cf4A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dou RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J

(Thermoplasma
volcanium) 		PF01728
(FtsJ) 		4 ILE A  64
GLY A  50
MET A  71
ILE A  63
 None
SAM  A   1 (-3.8A)
None
None
 0.82A 5j4nB-3douA:
undetectable		 5j4nB-3douA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e0x LIPASE-ESTERASE
RELATED PROTEIN

(Clostridium
acetobutylicum) 		PF12146
(Hydrolase_4) 		4 ILE A  83
GLY A   8
ASN A   9
ILE A  42
 None
 0.82A 5j4nB-3e0xA:
undetectable		 5j4nB-3e0xA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fh6 MALTOSE TRANSPORT
SYSTEM PERMEASE
PROTEIN MALF

(Escherichia
coli) 		PF00528
(BPD_transp_1)
PF14785
(MalF_P2) 		4 ILE F 333
GLY F 345
ASN F 341
ILE F 335
 None
 0.96A 5j4nB-3fh6F:
undetectable		 5j4nB-3fh6F:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gf7 GLUTACONYL-COA
DECARBOXYLASE
SUBUNIT A

([Clostridium]
symbiosum) 		PF01039
(Carboxyl_trans) 		4 ILE A 544
GLY A  99
ASN A  98
ILE A 478
 None
 0.80A 5j4nB-3gf7A:
undetectable		 5j4nB-3gf7A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gv0 TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY

(Agrobacterium
fabrum) 		PF13377
(Peripla_BP_3) 		4 ILE A 191
GLY A 206
ASN A 208
ILE A 253
 None
 0.92A 5j4nB-3gv0A:
undetectable		 5j4nB-3gv0A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h3b ANTI-ERBB2 ANTIBODY
CHA21

(Mus musculus) 		PF07686
(V-set) 		4 ILE C 185
GLY C 234
ASN C 235
ILE C 168
 None
 0.93A 5j4nB-3h3bC:
undetectable		 5j4nB-3h3bC:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j97 ALPHA-SOLUBLE NSF
ATTACHMENT PROTEIN

(Rattus
norvegicus) 		no annotation 4 ILE H 125
GLY H  89
ASN H  90
ILE H 127
 None
 0.95A 5j4nB-3j97H:
undetectable		 5j4nB-3j97H:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l0i DRRA

(Legionella
pneumophila) 		PF14860
(DrrA_P4M) 		4 ILE A 471
GLY A 363
ASN A 364
ILE A 467
 None
 0.86A 5j4nB-3l0iA:
undetectable		 5j4nB-3l0iA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l44 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
1

(Bacillus
anthracis) 		PF00202
(Aminotran_3) 		4 ILE A 128
GLY A 283
MET A 288
ILE A 240
 None
 1.00A 5j4nB-3l44A:
undetectable		 5j4nB-3l44A:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l7n PUTATIVE
UNCHARACTERIZED
PROTEIN

(Streptococcus
mutans) 		PF00117
(GATase) 		4 ILE A  86
GLY A  93
MET A  97
ILE A  50
 None
 0.91A 5j4nB-3l7nA:
undetectable		 5j4nB-3l7nA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mfd D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACB

(Bacillus
subtilis) 		PF00768
(Peptidase_S11)
PF07943
(PBP5_C) 		4 ILE A  38
GLY A 219
ASN A 206
ILE A 243
 None
 0.90A 5j4nB-3mfdA:
undetectable		 5j4nB-3mfdA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mzb NICKEL-BINDING
PERIPLASMIC PROTEIN

(Escherichia
coli) 		PF00496
(SBP_bac_5) 		4 ILE A 488
GLY A 219
ASN A 220
MET A 472
 None
DTD  A 522 (-3.4A)
DTD  A 522 (-3.0A)
None
 0.99A 5j4nB-3mzbA:
undetectable		 5j4nB-3mzbA:
23.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ncy ADIC

(Salmonella
enterica) 		PF13520
(AA_permease_2) 		6 ILE A  23
GLY A 100
ASN A 101
MET A 104
ILE A 205
TRP A 293
 None
 0.65A 5j4nB-3ncyA:
56.8		 5j4nB-3ncyA:
94.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ogz UDP-SUGAR
PYROPHOSPHORYLASE

(Leishmania
major) 		PF01704
(UDPGP) 		4 ILE A 498
GLY A 572
ASN A 570
ILE A 497
 None
 0.87A 5j4nB-3ogzA:
undetectable		 5j4nB-3ogzA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pqy ALPHA CHAIN OF THE
6218-TCR

(Homo sapiens;
Mus musculus) 		PF07686
(V-set)
PF09291
(DUF1968) 		4 ILE D 105
GLY D  30
ASN D  31
ILE D  39
 None
 0.76A 5j4nB-3pqyD:
undetectable		 5j4nB-3pqyD:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ptk BETA-GLUCOSIDASE
OS4BGLU12

(Oryza sativa) 		PF00232
(Glyco_hydro_1) 		4 ILE A 110
GLY A  99
ASN A  98
ILE A 162
 None
 0.96A 5j4nB-3ptkA:
undetectable		 5j4nB-3ptkA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pzl AGMATINE
UREOHYDROLASE

(Thermoplasma
volcanium) 		PF00491
(Arginase) 		4 ILE A 181
GLY A 209
ASN A 208
ILE A 179
 None
 1.01A 5j4nB-3pzlA:
undetectable		 5j4nB-3pzlA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rfn BB_1WNU_001

(Pyrococcus
horikoshii) 		no annotation 4 ILE A  43
GLY A  17
ASN A 112
ILE A 146
 None
 0.78A 5j4nB-3rfnA:
undetectable		 5j4nB-3rfnA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ry7 RIBOKINASE

(Staphylococcus
aureus) 		PF00294
(PfkB) 		4 ILE A  60
GLY A  41
ASN A  12
ILE A   7
 None
GOL  A 401 (-3.8A)
GOL  A 401 (-3.9A)
None
 0.92A 5j4nB-3ry7A:
undetectable		 5j4nB-3ry7A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s3f TYROSINE-PROTEIN
PHOSPHATASE 10D

(Drosophila
melanogaster) 		PF00102
(Y_phosphatase) 		4 ILE A 262
GLY A 108
ASN A 110
ILE A 258
 None
 0.94A 5j4nB-3s3fA:
undetectable		 5j4nB-3s3fA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tfm MYOSIN X

(Rattus
norvegicus) 		PF00169
(PH) 		4 ILE A 103
GLY A  58
ASN A  55
ILE A 115
 None
 0.96A 5j4nB-3tfmA:
undetectable		 5j4nB-3tfmA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u02 PUTATIVE
TRANSCRIPTION-ASSOCI
ATED PROTEIN TFIIS

(Pyrococcus
furiosus) 		PF08489
(DUF1743) 		4 ILE A  24
GLY A   6
MET A  60
ILE A  21
 None
None
None
TPO  A  18 ( 4.2A)
 0.94A 5j4nB-3u02A:
undetectable		 5j4nB-3u02A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w1j L-SERYL-TRNA(SEC)
SELENIUM TRANSFERASE

(Aquifex
aeolicus) 		PF03841
(SelA) 		4 ILE A 123
GLY A 117
ASN A 110
ILE A 120
 None
 0.90A 5j4nB-3w1jA:
undetectable		 5j4nB-3w1jA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wnv GLYOXYLATE REDUCTASE

(Paecilomyces
sp.
'thermophila') 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 ILE A 181
GLY A 166
ASN A 214
ILE A 180
 None
 1.00A 5j4nB-3wnvA:
undetectable		 5j4nB-3wnvA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wob HYPOTHETICAL PROTEIN

(Sus scrofa) 		PF01419
(Jacalin) 		4 ILE A  86
GLY A 132
ILE A  85
TRP A 149
 None
 1.00A 5j4nB-3wobA:
undetectable		 5j4nB-3wobA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zu0 NAD NUCLEOTIDASE

(Haemophilus
influenzae) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		4 ILE A 440
GLY A 493
ASN A 590
ILE A 415
 None
 0.78A 5j4nB-3zu0A:
undetectable		 5j4nB-3zu0A:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyv AOX3

(Mus musculus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		4 ILE A 734
GLY A 859
ASN A 858
ILE A 853
 None
 0.85A 5j4nB-3zyvA:
undetectable		 5j4nB-3zyvA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ak2 BT_4661

(Bacteroides
thetaiotaomicron) 		PF16319
(DUF4958) 		4 ILE A 694
GLY A 598
ASN A 606
ILE A 668
 None
None
None
NA  A1715 ( 4.7A)
 0.97A 5j4nB-4ak2A:
undetectable		 5j4nB-4ak2A:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bfi OX-2 MEMBRANE
GLYCOPROTEIN

(Mus musculus) 		PF00047
(ig) 		4 ILE B 168
GLY B 144
ILE B 128
TRP B 142
 NAG  B1270 ( 4.9A)
None
None
None
 0.87A 5j4nB-4bfiB:
undetectable		 5j4nB-4bfiB:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bil DNA MATURASE B

(Escherichia
virus T7) 		no annotation 4 ILE A 158
GLY A 144
MET A 171
ILE A  86
 None
 0.96A 5j4nB-4bilA:
undetectable		 5j4nB-4bilA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c02 ACTIVIN RECEPTOR
TYPE-1

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		4 ILE A 352
GLY A 348
ASN A 347
ILE A 312
 None
None
EDO  A1510 (-4.4A)
None
 0.96A 5j4nB-4c02A:
undetectable		 5j4nB-4c02A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cja BURRH

(Paraburkholderia
rhizoxinica) 		PF03377
(TAL_effector) 		4 ILE A 648
GLY A 655
ASN A 621
ILE A 651
 None
 1.00A 5j4nB-4cjaA:
undetectable		 5j4nB-4cjaA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cu8 GLYCOSIDE HYDROLASE
2

(Streptococcus
pneumoniae) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		4 ILE A 190
GLY A 924
ASN A 923
ILE A 714
 None
 0.97A 5j4nB-4cu8A:
undetectable		 5j4nB-4cu8A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dag FUSION GLYCOPROTEIN
F0
NEUTRALIZING
ANTIBODY DS7 HEAVY
CHAIN

(Homo sapiens;
Human
metapneumovirus) 		PF00523
(Fusion_gly)
PF07654
(C1-set)
PF07686
(V-set) 		4 ILE A 285
GLY H 104
ILE A 286
TRP A 284
 None
 0.87A 5j4nB-4dagA:
undetectable		 5j4nB-4dagA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hl7 NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE

(Vibrio cholerae) 		PF04095
(NAPRTase) 		4 ILE A 230
GLY A 348
MET A 184
ILE A 265
 None
 0.78A 5j4nB-4hl7A:
undetectable		 5j4nB-4hl7A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i5s VICK-LIKE PROTEIN
PUTATIVE HISTIDINE
KINASE COVS

(Streptococcus
mutans) 		PF00512
(HisKA)
PF00989
(PAS)
PF02518
(HATPase_c) 		4 ILE A 176
GLY A 190
ASN A 181
ILE A 139
 None
 0.78A 5j4nB-4i5sA:
undetectable		 5j4nB-4i5sA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jf7 HEMAGGLUTININ-NEURAM
INIDASE

(Mammalian
rubulavirus 5) 		no annotation 4 ILE D 199
GLY D 126
ASN D 125
ILE D 200
 None
 1.01A 5j4nB-4jf7D:
undetectable		 5j4nB-4jf7D:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l1m E3 UBIQUITIN-PROTEIN
LIGASE HERC2

(Homo sapiens) 		PF00415
(RCC1) 		4 ILE A 456
GLY A 470
ASN A 469
ILE A 498
 None
 1.00A 5j4nB-4l1mA:
undetectable		 5j4nB-4l1mA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nzj PUTATIVE
ALPHA-GALACTOSIDASE

(Bacteroides
fragilis) 		PF05345
(He_PIG)
PF10632
(He_PIG_assoc)
PF16499
(Melibiase_2) 		4 ILE A 305
GLY A 384
ASN A 385
ILE A 302
 None
 0.94A 5j4nB-4nzjA:
undetectable		 5j4nB-4nzjA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o5v IRON-DEPENDENT
TRANSCRIPTION
REPRESSOR RELATED
PROTEIN

(Thermoplasma
acidophilum) 		PF02742
(Fe_dep_repr_C)
PF04023
(FeoA) 		4 ILE A 149
GLY A 131
ASN A 132
ILE A 160
 None
 0.77A 5j4nB-4o5vA:
undetectable		 5j4nB-4o5vA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o96 TYPE III EFFECTOR
PROTEIN KINASE

(Escherichia
coli) 		no annotation 4 ILE A 269
GLY A 152
ASN A 154
ILE A 267
 None
None
None
GOL  A 401 (-4.6A)
 0.93A 5j4nB-4o96A:
undetectable		 5j4nB-4o96A:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ov4 2-ISOPROPYLMALATE
SYNTHASE

(Leptospira
biflexa) 		PF00682
(HMGL-like) 		4 ILE A 282
GLY A 242
ASN A 210
ILE A 280
 None
 0.98A 5j4nB-4ov4A:
undetectable		 5j4nB-4ov4A:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ovt TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Ochrobactrum
anthropi) 		PF03480
(DctP) 		4 ILE A 152
GLY A 147
ASN A 234
ILE A 211
 None
None
LFC  A 403 ( 4.9A)
None
 0.97A 5j4nB-4ovtA:
undetectable		 5j4nB-4ovtA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q60 PROLINE RACEMASE

(Burkholderia
multivorans) 		PF05544
(Pro_racemase) 		4 ILE A  94
GLY A 161
ASN A 163
ILE A 285
 None
None
None
PYC  A 402 (-3.8A)
 0.90A 5j4nB-4q60A:
undetectable		 5j4nB-4q60A:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qgu GAMMA-INTERFERON-IND
UCIBLE PROTEIN 16

(Homo sapiens) 		PF02760
(HIN) 		4 ILE A 260
GLY A 255
ASN A 254
ILE A 258
 None
 0.88A 5j4nB-4qguA:
undetectable		 5j4nB-4qguA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rkf RAS-RELATED PROTEIN
RAB-3

(Drosophila
melanogaster) 		PF00071
(Ras) 		4 ILE A  74
GLY A  33
ASN A 134
MET A 100
 None
GNP  A 201 (-3.2A)
GNP  A 201 (-3.3A)
None
 0.98A 5j4nB-4rkfA:
undetectable		 5j4nB-4rkfA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ypj BETA GALACTOSIDASE

(Bacillus
circulans) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		4 ILE A  87
GLY A 793
ASN A 792
ILE A 599
 None
 0.99A 5j4nB-4ypjA:
undetectable		 5j4nB-4ypjA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yr1 ALKALINE PHOSPHATASE

(Escherichia
coli) 		PF00245
(Alk_phosphatase) 		4 ILE A 365
GLY A 144
ASN A 145
ILE A  45
 None
 0.91A 5j4nB-4yr1A:
undetectable		 5j4nB-4yr1A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d95 AMINOTRANSFERASE
CLASS-III

(Sphaerobacter
thermophilus) 		PF00202
(Aminotran_3) 		4 ILE A 135
GLY A 295
MET A 300
ILE A 253
 None
 1.00A 5j4nB-5d95A:
undetectable		 5j4nB-5d95A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dzs SHIKIMATE
DEHYDROGENASE
(NADP(+))

(Clostridioides
difficile) 		PF08501
(Shikimate_dh_N) 		4 ILE A 177
GLY A 222
ASN A 223
ILE A 178
 None
 0.87A 5j4nB-5dzsA:
undetectable		 5j4nB-5dzsA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fd2 SERINE/THREONINE-PRO
TEIN KINASE B-RAF

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 ILE A 573
GLY A 593
ASN A 581
ILE A 572
 None
5XJ  A 801 ( 3.7A)
None
None
 1.00A 5j4nB-5fd2A:
undetectable		 5j4nB-5fd2A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fud O-ACETYL-ADP-RIBOSE
DEACETYLASE

(Oceanobacillus
iheyensis) 		PF01661
(Macro) 		4 ILE A  87
GLY A  31
ASN A  30
ILE A  74
 None
None
MES  A1188 (-4.1A)
None
 0.97A 5j4nB-5fudA:
undetectable		 5j4nB-5fudA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hjn LD10117P

(Drosophila
melanogaster) 		PF00566
(RabGAP-TBC) 		4 ILE A 320
GLY A 310
ASN A 311
ILE A 286
 None
 0.91A 5j4nB-5hjnA:
undetectable		 5j4nB-5hjnA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kqc PEPTIDASE M23

(Staphylococcus
aureus) 		PF01551
(Peptidase_M23) 		4 ILE A 142
GLY A  95
ASN A  94
ILE A 143
 None
 1.00A 5j4nB-5kqcA:
undetectable		 5j4nB-5kqcA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2

(Homo sapiens) 		PF00856
(SET) 		4 ILE A1128
GLY A1185
ASN A1186
ILE A1127
 None
None
SAM  A1304 (-3.6A)
None
 0.91A 5j4nB-5lsuA:
undetectable		 5j4nB-5lsuA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mdq CHITOPORIN

(Vibrio harveyi) 		no annotation 4 ILE A 153
GLY A 205
ASN A 206
TRP A 185
 None
 0.92A 5j4nB-5mdqA:
undetectable		 5j4nB-5mdqA:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n7z LIPOPOLYSACCHARIDE
1,6-GALACTOSYLTRANSF
ERASE

(Salmonella
enterica) 		no annotation 4 ILE A  55
GLY A  14
ILE A  20
TRP A  51
 None
 0.86A 5j4nB-5n7zA:
undetectable		 5j4nB-5n7zA:
10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nla PUTATIVE
TRANSCRIPTIONAL
REGULATOR
TRANSCRIPTION
REGULATOR PROTEIN

(Sinorhizobium
meliloti) 		PF12833
(HTH_18)
PF14525
(AraC_binding_2) 		4 ILE A 205
GLY A 213
ASN A 214
ILE A  99
 None
 0.94A 5j4nB-5nlaA:
undetectable		 5j4nB-5nlaA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vm6 SINGLE DOMAIN
CAMELID NANOBODY VHH
T10

(Lama glama) 		no annotation 4 ILE A  35
GLY A  80
ASN A  79
ILE A  53
 None
9EG  A 203 ( 3.9A)
9EG  A 203 (-3.3A)
None
 0.82A 5j4nB-5vm6A:
undetectable		 5j4nB-5vm6A:
11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wrk AP-2 COMPLEX SUBUNIT
MU

(Rattus
norvegicus) 		no annotation 4 ILE A 307
GLY A 189
MET A 185
ILE A 290
 None
 0.98A 5j4nB-5wrkA:
undetectable		 5j4nB-5wrkA:
8.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xhw PUTATIVE
6-DEOXY-D-MANNOHEPTO
SE PATHWAY PROTEIN

(Yersinia
pseudotuberculosis) 		no annotation 4 ILE A 211
GLY A 141
ASN A 166
ILE A 213
 None
 1.00A 5j4nB-5xhwA:
undetectable		 5j4nB-5xhwA:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Komagataella
phaffii) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		4 ILE B 910
GLY B 947
ASN B 946
ILE B 911
 None
 1.00A 5j4nB-5xogB:
undetectable		 5j4nB-5xogB:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b9s METHYLPHOSPHONATE
SYNTHASE

(Nitrosopumilus
maritimus) 		no annotation 4 ILE A 372
GLY A 410
ASN A 411
ILE A 414
 None
 0.93A 5j4nB-6b9sA:
undetectable		 5j4nB-6b9sA:
10.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cp7 ATP SYNTHASE SUBUNIT
A

(Saccharomyces
cerevisiae) 		no annotation 4 ILE X 171
GLY X 128
ILE X 123
TRP X 126
 None
 0.96A 5j4nB-6cp7X:
0.7		 5j4nB-6cp7X:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fos PHOTOSYSTEM I
REACTION CENTER
SUBUNIT X

(Cyanidioschyzon
merolae) 		no annotation 4 ILE K  45
GLY K  20
ASN K  17
ILE K  46
 None
 0.98A 5j4nB-6fosK:
undetectable		 5j4nB-6fosK:
8.31