SIMILAR PATTERNS OF AMINO ACIDS FOR 5J2T_C_VLBC503

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a0i DNA LIGASE

(Escherichia
virus T7)
PF01068
(DNA_ligase_A_M)
5 LYS A  97
VAL A  96
ASP A 100
THR A 115
LEU A 139
None
1.38A 5j2tB-1a0iA:
undetectable
5j2tB-1a0iA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t61 TYPE IV COLLAGEN

(Bos taurus)
PF01413
(C4)
5 VAL A  36
ASP A  78
TYR A  35
PHE A 173
LEU A  33
None
CL  A 810 (-4.9A)
None
None
None
1.45A 5j2tB-1t61A:
undetectable
5j2tB-1t61A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b39 C3

(Bos taurus)
PF00207
(A2M)
PF01759
(NTR)
PF01821
(ANATO)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl)
5 LYS A1083
VAL A1081
TYR A1080
TYR A1065
LEU A1077
None
1.36A 5j2tB-2b39A:
0.0
5j2tB-2b39A:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zab ALGINATE LYASE

(Sphingomonas
sp. A1)
PF08787
(Alginate_lyase2)
5 PHE A  89
THR A 122
PRO A  85
TYR A 115
LEU A 111
GOL  A 601 ( 4.6A)
None
None
None
None
1.49A 5j2tB-2zabA:
0.0
5j2tB-2zabA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gmt ADENYLATE KINASE

(Burkholderia
pseudomallei)
PF00406
(ADK)
PF05191
(ADK_lid)
5 VAL A 106
ASP A 104
TYR A 182
PRO A  87
LEU A   6
None
1.27A 5j2tB-3gmtA:
1.9
5j2tB-3gmtA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kx6 FRUCTOSE-BISPHOSPHAT
E ALDOLASE


(Babesia bovis)
PF00274
(Glycolytic)
5 VAL A 105
ASP A  31
THR A 122
TYR A 172
LEU A 127
None
1.31A 5j2tB-3kx6A:
0.0
5j2tB-3kx6A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oc5 TOXIN COREGULATED
PILUS BIOSYNTHESIS
PROTEIN F


(Vibrio cholerae)
PF06340
(TcpF)
5 ASP A  97
THR A 111
PRO A 110
TYR A 148
LEU A 141
None
1.45A 5j2tB-3oc5A:
0.0
5j2tB-3oc5A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vss BETA-FRUCTOFURANOSID
ASE


(Microbacterium
saccharophilum)
PF02435
(Glyco_hydro_68)
5 VAL A 136
ASP A 138
PHE A 470
THR A 485
TYR A 174
None
1.05A 5j2tB-3vssA:
0.0
5j2tB-3vssA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4myr CPAE2 PILUS ASSEMBLY
PROTEIN


(Sinorhizobium
meliloti)
no annotation 5 VAL A  83
ASP A  32
THR A 107
TYR A  74
LEU A 101
None
1.28A 5j2tB-4myrA:
2.3
5j2tB-4myrA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n3n EUKARYOTIC
TRANSLATION
INITIATION FACTOR
5B-LIKE PROTEIN,
EIF5B(517-C)


(Chaetomium
thermophilum)
PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF11987
(IF-2)
5 VAL A 875
ASP A 909
PHE A 929
THR A 879
LEU A 887
None
1.31A 5j2tB-4n3nA:
2.0
5j2tB-4n3nA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4np6 ADENYLATE KINASE

(Vibrio cholerae)
PF00406
(ADK)
PF05191
(ADK_lid)
5 VAL A 106
ASP A 104
TYR A 182
PRO A  87
LEU A   6
None
1.12A 5j2tB-4np6A:
3.0
5j2tB-4np6A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bv9 CELLULOSE
1,4-BETA-CELLOBIOSID
ASE


(Bacillus
pumilus)
PF02011
(Glyco_hydro_48)
5 LYS A 431
VAL A 430
ASP A 434
TYR A 427
PHE A 547
ACT  A 810 (-4.9A)
None
None
None
None
1.48A 5j2tB-5bv9A:
undetectable
5j2tB-5bv9A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kdj F5/8 TYPE C DOMAIN
PROTEIN


(Clostridium
perfringens)
no annotation 5 VAL B 964
PHE B 966
THR B 988
TYR B 985
LEU B 940
None
1.44A 5j2tB-5kdjB:
undetectable
5j2tB-5kdjB:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kds F5/8 TYPE C DOMAIN
PROTEIN


(Clostridium
perfringens)
PF13402
(Peptidase_M60)
5 VAL A 964
PHE A 966
THR A 988
TYR A 985
LEU A 940
None
1.44A 5j2tB-5kdsA:
undetectable
5j2tB-5kdsA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ae1 TROPINONE
REDUCTASE-I


(Datura
stramonium)
PF13561
(adh_short_C2)
5 PRO A 238
VAL A 241
ILE A 245
ALA A 246
ILE A 204
None
None
None
None
NAP  A 274 (-4.4A)
0.82A 5j2tC-1ae1A:
7.3
5j2tC-1ae1A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bu8 PROTEIN (PANCREATIC
LIPASE RELATED
PROTEIN 2)


(Rattus
norvegicus)
PF00151
(Lipase)
PF01477
(PLAT)
6 LEU A 153
VAL A 124
ILE A 128
ALA A 129
PHE A  72
VAL A  74
None
0.93A 5j2tC-1bu8A:
4.5
5j2tC-1bu8A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1czf POLYGALACTURONASE II

(Aspergillus
niger)
PF00295
(Glyco_hydro_28)
5 VAL A 190
ILE A 192
PHE A 182
VAL A 184
GLY A 185
None
0.77A 5j2tC-1czfA:
undetectable
5j2tC-1czfA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dhs DEOXYHYPUSINE
SYNTHASE


(Homo sapiens)
PF01916
(DS)
5 LEU A 107
VAL A 286
ILE A 290
ALA A 291
PHE A 100
NAD  A 700 (-4.6A)
None
None
None
None
0.80A 5j2tC-1dhsA:
4.7
5j2tC-1dhsA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gae D-GLYCERALDEHYDE-3-P
HOSPHATE
DEHYDROGENASE


(Escherichia
coli)
PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C)
6 VAL O 321
ILE O 325
ALA O 326
VAL O  15
GLY O  12
ILE O  11
None
None
None
None
None
NAD  O 336 (-3.9A)
1.36A 5j2tC-1gaeO:
2.4
5j2tC-1gaeO:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iwl OUTER-MEMBRANE
LIPOPROTEINS CARRIER
PROTEIN


(Escherichia
coli)
PF03548
(LolA)
6 ASN A  96
ILE A  93
ALA A  94
PHE A 140
VAL A 131
GLY A 132
None
None
None
None
None
ZN  A 193 ( 4.6A)
1.10A 5j2tC-1iwlA:
undetectable
5j2tC-1iwlA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jhs MOG1 PROTEIN

(Saccharomyces
cerevisiae)
PF04603
(Mog1)
6 VAL A 108
ALA A 103
PHE A 134
VAL A 158
GLY A 157
ILE A 156
None
1.46A 5j2tC-1jhsA:
undetectable
5j2tC-1jhsA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1js1 TRANSCARBAMYLASE

(Bacteroides
fragilis)
PF00185
(OTCace)
PF02729
(OTCace_N)
5 LEU X  40
ILE X 126
VAL X 109
GLY X 108
ILE X 107
None
0.79A 5j2tC-1js1X:
undetectable
5j2tC-1js1X:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jwq N-ACETYLMURAMOYL-L-A
LANINE AMIDASE CWLV


(Paenibacillus
polymyxa)
PF01520
(Amidase_3)
6 LYS A  27
ASN A  30
ILE A  79
ALA A  34
VAL A 143
GLY A 144
None
1.46A 5j2tC-1jwqA:
4.1
5j2tC-1jwqA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k5c ENDOPOLYGALACTURONAS
E


(Chondrostereum
purpureum)
PF00295
(Glyco_hydro_28)
5 VAL A 162
ILE A 164
PHE A 155
VAL A 124
GLY A 125
None
0.82A 5j2tC-1k5cA:
undetectable
5j2tC-1k5cA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kv9 TYPE II
QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE


(Pseudomonas
putida)
PF13360
(PQQ_2)
PF13442
(Cytochrome_CBB3)
6 VAL A 246
ILE A 275
ALA A 274
PHE A 194
VAL A 180
GLY A 168
None
1.41A 5j2tC-1kv9A:
undetectable
5j2tC-1kv9A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n21 (+)-BORNYL
DIPHOSPHATE SYNTHASE


(Salvia
officinalis)
PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C)
5 LYS A 541
ASN A 544
ILE A 547
ALA A 548
ILE A 491
None
0.72A 5j2tC-1n21A:
undetectable
5j2tC-1n21A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q18 GLUCOKINASE

(Escherichia
coli)
PF02685
(Glucokinase)
5 PRO A 193
VAL A 196
ASN A 197
ALA A 201
LYS A 204
None
0.52A 5j2tC-1q18A:
undetectable
5j2tC-1q18A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qn2 CYTOCHROME CH

(Methylobacterium
extorquens)
PF00034
(Cytochrom_C)
5 PRO A  86
VAL A  89
ILE A  93
ALA A  94
LYS A  97
None
0.36A 5j2tC-1qn2A:
undetectable
5j2tC-1qn2A:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tc1 PROTEIN
(HYPOXANTHINE
PHOSPHORIBOSYLTRANSF
ERASE)


(Trypanosoma
cruzi)
PF00156
(Pribosyltran)
5 LEU A 140
VAL A  25
ILE A  29
ALA A  30
VAL A 138
None
0.79A 5j2tC-1tc1A:
3.4
5j2tC-1tc1A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ulv GLUCODEXTRANASE

(Arthrobacter
globiformis)
PF00723
(Glyco_hydro_15)
PF09136
(Glucodextran_B)
PF09137
(Glucodextran_N)
PF09985
(Glucodextran_C)
5 VAL A 928
ILE A 846
PHE A 822
VAL A 811
GLY A 810
None
0.83A 5j2tC-1ulvA:
undetectable
5j2tC-1ulvA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vjn ZN-DEPENDENT
HYDROLASE OF
METALLO-BETA-LACTAMA
SE SUPERFAMILY
TM0207


(Thermotoga
maritima)
PF13483
(Lactamase_B_3)
5 ILE A  20
ALA A  12
PHE A  99
VAL A  74
GLY A  73
None
0.79A 5j2tC-1vjnA:
undetectable
5j2tC-1vjnA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vk1 CONSERVED
HYPOTHETICAL PROTEIN


(Pyrococcus
furiosus)
PF02195
(ParBc)
5 VAL A 110
ASN A 111
ILE A 114
LYS A 118
GLY A 145
None
0.82A 5j2tC-1vk1A:
undetectable
5j2tC-1vk1A:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vlu GAMMA-GLUTAMYL
PHOSPHATE REDUCTASE


(Saccharomyces
cerevisiae)
PF00171
(Aldedh)
5 VAL A 162
ASN A 163
ILE A 166
ALA A 167
ILE A 129
None
0.56A 5j2tC-1vluA:
undetectable
5j2tC-1vluA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vpe PHOSPHOGLYCERATE
KINASE


(Thermotoga
maritima)
PF00162
(PGK)
5 LYS A 333
VAL A 335
ILE A 339
ALA A 340
ILE A 296
None
0.82A 5j2tC-1vpeA:
undetectable
5j2tC-1vpeA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vpe PHOSPHOGLYCERATE
KINASE


(Thermotoga
maritima)
PF00162
(PGK)
5 LYS A 333
VAL A 335
ILE A 339
ALA A 340
VAL A 192
None
0.66A 5j2tC-1vpeA:
undetectable
5j2tC-1vpeA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y1p ALDEHYDE REDUCTASE
II


(Sporidiobolus
salmonicolor)
PF01370
(Epimerase)
5 LEU A  33
VAL A  17
ILE A  91
ALA A  92
VAL A  28
None
None
NMN  A1001 (-4.9A)
AMP  A1002 (-3.7A)
None
0.77A 5j2tC-1y1pA:
5.2
5j2tC-1y1pA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ytu HYPOTHETICAL PROTEIN
AF1318


(Archaeoglobus
fulgidus)
PF02171
(Piwi)
5 PRO A 394
LYS A 395
VAL A 397
ILE A 401
ALA A 402
None
0.57A 5j2tC-1ytuA:
undetectable
5j2tC-1ytuA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z1w TRICORN PROTEASE
INTERACTING FACTOR
F3


(Thermoplasma
acidophilum)
PF01433
(Peptidase_M1)
PF11838
(ERAP1_C)
6 VAL A 125
ILE A 123
ALA A 122
VAL A 165
GLY A 166
ILE A 167
None
1.42A 5j2tC-1z1wA:
undetectable
5j2tC-1z1wA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zpv ACT DOMAIN PROTEIN

(Streptococcus
pneumoniae)
PF13740
(ACT_6)
6 LEU A  70
VAL A   7
ILE A   5
VAL A  19
GLY A  18
ILE A  15
None
1.33A 5j2tC-1zpvA:
undetectable
5j2tC-1zpvA:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b67 COG0778:
NITROREDUCTASE


(Streptococcus
pneumoniae)
PF00881
(Nitroreductase)
5 PRO A  23
VAL A  26
ILE A  30
PHE A  47
VAL A  49
None
0.51A 5j2tC-2b67A:
undetectable
5j2tC-2b67A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bp5 CLATHRIN COAT
ASSEMBLY PROTEIN
AP50


(Rattus
norvegicus)
PF00928
(Adap_comp_sub)
6 LYS M 354
VAL M 322
ILE M 324
ALA M 350
VAL M 305
ILE M 307
None
1.27A 5j2tC-2bp5M:
undetectable
5j2tC-2bp5M:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2buf ACETYLGLUTAMATE
KINASE


(Pseudomonas
aeruginosa)
PF00696
(AA_kinase)
5 VAL A 239
ASN A 240
ILE A 243
ALA A 244
ILE A 295
None
0.83A 5j2tC-2bufA:
2.6
5j2tC-2bufA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ilu ALDEHYDE
DEHYDROGENASE A


(Escherichia
coli)
PF00171
(Aldedh)
5 ASN A 183
ILE A 186
ALA A 187
LYS A 190
ILE A  24
None
0.66A 5j2tC-2iluA:
undetectable
5j2tC-2iluA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iq7 ENDOPOLYGALACTURONAS
E


(Colletotrichum
lupini)
PF00295
(Glyco_hydro_28)
5 VAL A 188
ILE A 190
PHE A 180
VAL A 182
GLY A 183
None
0.69A 5j2tC-2iq7A:
undetectable
5j2tC-2iq7A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jk0 L-ASPARAGINASE

(Pectobacterium
carotovorum)
PF00710
(Asparaginase)
6 LYS A  75
VAL A  77
ASN A  78
ALA A  82
VAL A 115
ILE A  91
None
1.46A 5j2tC-2jk0A:
undetectable
5j2tC-2jk0A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pfk 6-PHOSPHOFRUCTOKINAS
E ISOZYME I


(Escherichia
coli)
PF00365
(PFK)
5 VAL A  23
ALA A  18
VAL A   6
GLY A   5
ILE A   4
None
0.81A 5j2tC-2pfkA:
undetectable
5j2tC-2pfkA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4


(Saccharopolyspora
erythraea)
PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc)
6 LEU A 887
PRO A 473
ILE A 491
ALA A 488
VAL A 505
GLY A 504
None
1.43A 5j2tC-2qo3A:
undetectable
5j2tC-2qo3A:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v7z HEAT SHOCK COGNATE
71 KDA PROTEIN


(Rattus
norvegicus)
PF00012
(HSP70)
5 VAL A 238
ASN A 239
ILE A 242
ALA A 243
LYS A 246
None
0.72A 5j2tC-2v7zA:
undetectable
5j2tC-2v7zA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v82 2-DEHYDRO-3-DEOXY-6-
PHOSPHOGALACTONATE
ALDOLASE


(Escherichia
coli)
PF01081
(Aldolase)
6 VAL A  36
ILE A  38
ALA A  64
VAL A  25
GLY A  26
ILE A  29
None
1.30A 5j2tC-2v82A:
undetectable
5j2tC-2v82A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vbi PYRUVATE
DECARBOXYLASE


(Acetobacter
pasteurianus)
PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
5 PRO A 507
LYS A 508
ILE A 514
ALA A 515
LYS A 518
None
0.68A 5j2tC-2vbiA:
2.3
5j2tC-2vbiA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vj5 PROTEIN MXIC

(Shigella
flexneri)
PF07201
(HrpJ)
5 LYS A 155
VAL A 157
ASN A 158
ILE A 161
VAL A 122
None
0.82A 5j2tC-2vj5A:
undetectable
5j2tC-2vj5A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x30 PHOSPHORIBOSYL
ISOMERASE A


(Streptomyces
coelicolor)
PF00977
(His_biosynth)
6 LEU A 108
VAL A 114
ILE A 118
ALA A 119
VAL A 127
GLY A 104
None
None
None
None
None
SO4  A1241 (-3.3A)
1.39A 5j2tC-2x30A:
undetectable
5j2tC-2x30A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x7x SENSOR PROTEIN

(Bacteroides
thetaiotaomicron)
PF13407
(Peripla_BP_4)
6 VAL A 143
ILE A 147
ALA A 148
VAL A 245
GLY A 246
ILE A 247
None
1.17A 5j2tC-2x7xA:
undetectable
5j2tC-2x7xA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yjp PUTATIVE ABC
TRANSPORTER,
PERIPLASMIC BINDING
PROTEIN, AMINO ACID


(Neisseria
gonorrhoeae)
PF00497
(SBP_bac_3)
5 VAL A 247
ASN A 248
ILE A 251
ALA A 252
LYS A 255
None
0.48A 5j2tC-2yjpA:
undetectable
5j2tC-2yjpA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zj4 GLUCOSAMINE--FRUCTOS
E-6-PHOSPHATE
AMINOTRANSFERASE
[ISOMERIZING] 1


(Homo sapiens)
PF01380
(SIS)
5 LEU A 419
ILE A 362
VAL A 443
GLY A 444
ILE A 445
None
0.73A 5j2tC-2zj4A:
3.9
5j2tC-2zj4A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dnf 4-HYDROXY-3-METHYLBU
T-2-ENYL DIPHOSPHATE
REDUCTASE


(Aquifex
aeolicus)
PF02401
(LYTB)
5 LYS A 173
VAL A 175
ILE A 179
ALA A 180
VAL A 144
None
0.83A 5j2tC-3dnfA:
undetectable
5j2tC-3dnfA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hvy CYSTATHIONINE
BETA-LYASE FAMILY
PROTEIN, YNBB
B.SUBTILIS ORTHOLOG


(Clostridium
acetobutylicum)
PF06838
(Met_gamma_lyase)
6 VAL A 216
ILE A 237
ALA A 238
PHE A  86
GLY A 233
ILE A 202
None
1.24A 5j2tC-3hvyA:
2.7
5j2tC-3hvyA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jzl PUTATIVE
CYSTATHIONINE
BETA-LYASE INVOLVED
IN ALUMINUM
RESISTANCE


(Listeria
monocytogenes)
PF06838
(Met_gamma_lyase)
6 VAL A 199
ILE A 220
ALA A 221
PHE A  71
GLY A 216
ILE A 185
None
1.31A 5j2tC-3jzlA:
4.0
5j2tC-3jzlA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l2e GLYCOCYAMINE KINASE
ALPHA CHAIN


(Namalycastis
sp. ST01)
PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN)
6 VAL A 368
ASN A 369
ILE A 372
ALA A 373
LYS A 376
VAL A 137
None
0.80A 5j2tC-3l2eA:
undetectable
5j2tC-3l2eA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm7 PUTATIVE
4-HYDROXY-2-OXOGLUTA
RATE ALDOLASE /
2-DEHYDRO-3-DEOXYPHO
SPHOGLUCONATE
ALDOLASE


(Yersinia
enterocolitica)
PF07071
(KDGP_aldolase)
5 VAL A 144
ILE A 148
ALA A 149
LYS A 152
PHE A 185
None
0.84A 5j2tC-3lm7A:
undetectable
5j2tC-3lm7A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lpp SUCRASE-ISOMALTASE

(Homo sapiens)
PF00088
(Trefoil)
PF01055
(Glyco_hydro_31)
PF16863
(NtCtMGAM_N)
5 LEU A 881
ILE A 827
PHE A 842
VAL A 845
ILE A 847
None
0.78A 5j2tC-3lppA:
undetectable
5j2tC-3lppA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nzr 2-DEHYDRO-3-DEOXYPHO
SPHOGLUCONATE
ALDOLASE


(Aliivibrio
fischeri)
PF07071
(KDGP_aldolase)
5 VAL A 144
ILE A 148
ALA A 149
LYS A 152
PHE A 185
None
0.80A 5j2tC-3nzrA:
undetectable
5j2tC-3nzrA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pqv RCL1 PROTEIN

(Kluyveromyces
lactis)
PF01137
(RTC)
PF05189
(RTC_insert)
5 PRO A 201
VAL A 204
ASN A 205
ILE A 208
LYS A 212
None
0.73A 5j2tC-3pqvA:
undetectable
5j2tC-3pqvA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r4v PUTATIVE
UNCHARACTERIZED
PROTEIN


(Pseudomonas
phage 201phi2-1)
PF00091
(Tubulin)
5 ASN A 165
ILE A 168
ALA A 169
VAL A 118
GLY A 119
GDP  A 400 (-2.9A)
None
None
GDP  A 400 (-4.6A)
None
0.77A 5j2tC-3r4vA:
19.7
5j2tC-3r4vA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r79 UNCHARACTERIZED
PROTEIN


(Agrobacterium
fabrum)
PF01168
(Ala_racemase_N)
6 VAL A  11
ILE A  15
ALA A  16
VAL A 212
GLY A 213
ILE A 216
None
1.48A 5j2tC-3r79A:
undetectable
5j2tC-3r79A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ro8 ENDO-1,4-BETA-XYLANA
SE


(Paenibacillus
sp. JDR-2)
PF00331
(Glyco_hydro_10)
6 VAL A 209
ILE A 205
ALA A 204
LYS A 201
VAL A 229
GLY A 228
None
1.20A 5j2tC-3ro8A:
undetectable
5j2tC-3ro8A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wiq KOJIBIOSE
PHOSPHORYLASE


(Caldicellulosiruptor
saccharolyticus)
PF03632
(Glyco_hydro_65m)
PF03633
(Glyco_hydro_65C)
PF03636
(Glyco_hydro_65N)
5 LEU A 187
PRO A  69
VAL A 198
GLY A 199
ILE A 200
None
0.58A 5j2tC-3wiqA:
undetectable
5j2tC-3wiqA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zt9 SERINE PHOSPHATASE

(Moorella
thermoacetica)
PF07228
(SpoIIE)
5 VAL A  25
ILE A  32
VAL A   6
GLY A   7
ILE A   8
None
0.55A 5j2tC-3zt9A:
undetectable
5j2tC-3zt9A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a3s 6-PHOSPHOFRUCTOKINAS
E


(Bacillus
subtilis)
PF00365
(PFK)
5 VAL A  23
ALA A  18
VAL A   6
GLY A   5
ILE A   4
None
0.80A 5j2tC-4a3sA:
undetectable
5j2tC-4a3sA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ae0 DIPHTHERIA TOXIN

(Corynebacterium
diphtheriae)
PF01324
(Diphtheria_R)
PF02763
(Diphtheria_C)
PF02764
(Diphtheria_T)
5 LEU A 434
ILE A 420
VAL A 511
GLY A 510
ILE A 509
None
0.77A 5j2tC-4ae0A:
undetectable
5j2tC-4ae0A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ci0 F420-REDUCING
HYDROGENASE, SUBUNIT
BETA


(Methanothermobacter
marburgensis)
PF04422
(FrhB_FdhB_N)
PF04432
(FrhB_FdhB_C)
5 VAL C  29
ALA C  34
VAL C 130
GLY C 131
ILE C 132
FAD  C1283 (-4.0A)
None
None
None
FAD  C1283 (-3.6A)
0.79A 5j2tC-4ci0C:
undetectable
5j2tC-4ci0C:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fk9 CELLULOSE-BINDING
FAMILY II


(Streptomyces
sp. SirexAA-E)
PF00150
(Cellulase)
5 PRO A 114
VAL A 117
ILE A 121
ALA A 122
LYS A 125
None
0.50A 5j2tC-4fk9A:
undetectable
5j2tC-4fk9A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fxt UNCHARACTERIZED
PROTEIN


(Bacteroides
ovatus)
PF12866
(DUF3823)
6 LEU A 171
ILE A 140
PHE A 120
VAL A 152
GLY A 153
ILE A 154
None
1.35A 5j2tC-4fxtA:
undetectable
5j2tC-4fxtA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g1k TRIOSEPHOSPHATE
ISOMERASE


(Burkholderia
thailandensis)
PF00121
(TIM)
5 VAL A  29
ALA A  24
VAL A  44
GLY A  43
ILE A  42
None
0.82A 5j2tC-4g1kA:
undetectable
5j2tC-4g1kA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g6j LIGHT CHAIN OF
ANTIBODY BINDING
FRAGMENT OF
CANAKINUMAB


(Homo sapiens)
PF07654
(C1-set)
PF07686
(V-set)
6 LEU L  73
VAL L 104
ILE L 106
ALA L  80
VAL L  19
ILE L  21
None
1.45A 5j2tC-4g6jL:
undetectable
5j2tC-4g6jL:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h16 SHORT CHAIN ALCOHOL
DEHYDROGENASE-RELATE
D DEHYDROGENASE


(Sinorhizobium
meliloti)
PF13561
(adh_short_C2)
5 PRO A 226
VAL A 229
ILE A 233
ALA A 234
ILE A 184
None
0.78A 5j2tC-4h16A:
7.2
5j2tC-4h16A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hwi HEAT SHOCK COGNATE
71 KDA PROTEIN


(Homo sapiens)
PF00012
(HSP70)
6 VAL A 238
ASN A 239
ILE A 242
ALA A 243
LYS A 246
VAL A 260
None
1.11A 5j2tC-4hwiA:
undetectable
5j2tC-4hwiA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i4i 6-PHOSPHOFRUCTOKINAS
E


(Geobacillus
stearothermophilus)
PF00365
(PFK)
6 LEU A 275
VAL A  23
ILE A  20
ALA A  18
VAL A   6
ILE A   4
None
1.32A 5j2tC-4i4iA:
undetectable
5j2tC-4i4iA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i4i 6-PHOSPHOFRUCTOKINAS
E


(Geobacillus
stearothermophilus)
PF00365
(PFK)
6 VAL A  23
ILE A  20
ALA A  18
VAL A   6
GLY A   5
ILE A   4
None
0.97A 5j2tC-4i4iA:
undetectable
5j2tC-4i4iA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i7z APOCYTOCHROME F

(Mastigocladus
laminosus)
PF01333
(Apocytochr_F_C)
PF16639
(Apocytochr_F_N)
5 LEU C  41
PRO C 252
VAL C 255
ILE C 259
ALA C 260
None
None
None
None
OZ2  C 303 ( 4.3A)
0.82A 5j2tC-4i7zC:
undetectable
5j2tC-4i7zC:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iiw LMO1499 PROTEIN

(Listeria
monocytogenes)
PF02618
(YceG)
6 LEU A 179
LYS A 206
ILE A 212
ALA A 213
PHE A 229
GLY A 181
None
0.96A 5j2tC-4iiwA:
undetectable
5j2tC-4iiwA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jqp 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE


(Paraburkholderia
phymatum)
PF04166
(PdxA)
5 LEU A 274
ILE A 240
VAL A 218
GLY A 217
ILE A 216
None
0.80A 5j2tC-4jqpA:
undetectable
5j2tC-4jqpA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ke4 HYDROXYCINNAMOYL-COA
:SHIKIMATE
HYDROXYCINNAMOYL
TRANSFERASE


(Sorghum bicolor)
PF02458
(Transferase)
6 LEU A 252
LYS A 243
VAL A 429
ILE A 431
ALA A 240
VAL A 277
None
1.28A 5j2tC-4ke4A:
undetectable
5j2tC-4ke4A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kg7 PEPTIDASE S8 AND
S53, SUBTILISIN,
KEXIN, SEDOLISIN


(Mycolicibacterium
smegmatis)
PF00082
(Peptidase_S8)
6 LEU A 353
PRO A 392
VAL A 390
ILE A 305
ALA A 387
GLY A 349
None
1.40A 5j2tC-4kg7A:
undetectable
5j2tC-4kg7A:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n77 UNCHARACTERIZED
PROTEIN


(Thermus
thermophilus)
PF09704
(Cas_Cas5d)
5 LEU A   4
VAL A  35
PHE A 126
VAL A 128
GLY A 129
None
0.57A 5j2tC-4n77A:
undetectable
5j2tC-4n77A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p8r GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE,
CYTOSOLIC


(Trypanosoma
brucei)
PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C)
6 LYS A 321
VAL A 322
ILE A 326
ALA A 327
VAL A  94
ILE A  13
None
None
None
None
None
NAD  A 400 (-4.3A)
1.33A 5j2tC-4p8rA:
undetectable
5j2tC-4p8rA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pj1 60 KDA HEAT SHOCK
PROTEIN,
MITOCHONDRIAL


(Homo sapiens)
PF00118
(Cpn60_TCP1)
5 VAL A 124
ILE A 128
ALA A 129
LYS A 132
GLY A 510
None
0.69A 5j2tC-4pj1A:
undetectable
5j2tC-4pj1A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qcc 2-DEHYDRO-3-DEOXY-6-
PHOSPHOGALACTONATE
ALDOLASE,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
CHIMERA


(Escherichia
coli)
PF01081
(Aldolase)
PF01346
(FKBP_N)
6 VAL A  36
ILE A  38
ALA A  64
VAL A  25
GLY A  26
ILE A  29
None
1.30A 5j2tC-4qccA:
undetectable
5j2tC-4qccA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r9v SIALYLTRANSFERASE
0160


(Photobacterium
damselae)
PF11477
(PM0188)
6 VAL A 375
ASN A 379
ILE A 378
ALA A 381
GLY A 413
ILE A 410
None
1.45A 5j2tC-4r9vA:
5.6
5j2tC-4r9vA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ry9 PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR


(Verminephrobacter
eiseniae)
PF13407
(Peripla_BP_4)
5 LEU A  94
ALA A  52
VAL A  40
GLY A  39
ILE A  38
None
0.74A 5j2tC-4ry9A:
4.0
5j2tC-4ry9A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u28 PHOSPHORIBOSYL
ISOMERASE A


(Streptomyces
sviceus)
PF00977
(His_biosynth)
6 LEU A 112
VAL A 118
ILE A 122
ALA A 123
VAL A 131
GLY A 108
None
None
None
None
None
PO4  A 302 (-3.3A)
1.42A 5j2tC-4u28A:
undetectable
5j2tC-4u28A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ymx ABC-TYPE AMINO ACID
TRANSPORT SYSTEM,
PERIPLASMIC
COMPONENT


(Caldanaerobacter
subterraneus)
PF00497
(SBP_bac_3)
5 VAL A 237
ASN A 238
ILE A 241
LYS A 245
VAL A 224
None
0.70A 5j2tC-4ymxA:
undetectable
5j2tC-4ymxA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z42 UREASE SUBUNIT ALPHA

(Yersinia
enterocolitica)
PF00449
(Urease_alpha)
PF01979
(Amidohydro_1)
5 LEU C  70
ILE C  77
VAL C  89
GLY C  90
ILE C  91
None
0.70A 5j2tC-4z42C:
2.3
5j2tC-4z42C:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c5h 2-SUCCINYLBENZOATE--
COA LIGASE


(Escherichia
coli)
PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
5 PRO A 364
VAL A 367
ILE A 371
ALA A 372
ILE A 362
None
0.79A 5j2tC-5c5hA:
undetectable
5j2tC-5c5hA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eaw DNA REPLICATION
ATP-DEPENDENT
HELICASE/NUCLEASE
DNA2


(Mus musculus)
PF08696
(Dna2)
PF13086
(AAA_11)
PF13087
(AAA_12)
5 LEU A 978
ILE A 951
VAL A 940
GLY A 939
ILE A 938
None
0.76A 5j2tC-5eawA:
undetectable
5j2tC-5eawA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5evl BETA-LACTAMASE

(Chromobacterium
violaceum)
PF00144
(Beta-lactamase)
5 LEU A 327
VAL A 360
VAL A 334
GLY A 335
ILE A 336
None
0.79A 5j2tC-5evlA:
undetectable
5j2tC-5evlA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h3h ABHYDROLASE
DOMAIN-CONTAINING
PROTEIN


(Exiguobacterium
antarcticum)
PF00561
(Abhydrolase_1)
PF08386
(Abhydrolase_4)
6 VAL A  81
ILE A  13
ALA A   7
VAL A  54
GLY A  53
ILE A  52
None
1.41A 5j2tC-5h3hA:
4.4
5j2tC-5h3hA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5inw PUTATIVE
ANGIOTENSINOGEN


(Lampetra
fluviatilis)
PF00079
(Serpin)
6 LEU A 239
VAL A 119
ALA A 113
VAL A 413
GLY A 414
ILE A 415
None
1.23A 5j2tC-5inwA:
undetectable
5j2tC-5inwA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m2n ELONGATOR COMPLEX
PROTEIN 2


(Saccharomyces
cerevisiae)
PF00400
(WD40)
6 PRO A 751
VAL A 773
ILE A 391
ALA A 402
GLY A 723
ILE A 729
None
1.38A 5j2tC-5m2nA:
undetectable
5j2tC-5m2nA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mdn DNA POLYMERASE

(Pyrobaculum
calidifontis)
PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1)
6 LEU A 608
VAL A 638
ILE A 758
ALA A 755
GLY A 607
ILE A 614
None
1.28A 5j2tC-5mdnA:
undetectable
5j2tC-5mdnA:
21.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mjs TUBULIN ALPHA-1
CHAIN


(Schizosaccharomyces
pombe)
no annotation 5 PRO E 329
VAL E 332
PHE E 355
GLY E 358
ILE E 359
None
0.78A 5j2tC-5mjsE:
53.3
5j2tC-5mjsE:
68.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n28 METHYL-COENZYME M
REDUCTASE SUBUNIT
ALPHA


(Methanotorris
formicicus)
PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N)
5 PRO A 367
VAL A 371
ILE A 375
ALA A 376
GLY A 364
None
0.82A 5j2tC-5n28A:
undetectable
5j2tC-5n28A:
21.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5nd4 TUBULIN ALPHA CHAIN

(Bos taurus)
PF00091
(Tubulin)
PF03953
(Tubulin_C)
8 PRO A 325
VAL A 328
ASN A 329
ILE A 332
ALA A 333
PHE A 351
GLY A 354
ILE A 355
None
1.01A 5j2tC-5nd4A:
54.1
5j2tC-5nd4A:
92.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5nd4 TUBULIN ALPHA CHAIN

(Bos taurus)
PF00091
(Tubulin)
PF03953
(Tubulin_C)
8 PRO A 325
VAL A 328
ILE A 332
ALA A 333
PHE A 351
VAL A 353
GLY A 354
ILE A 355
None
1.01A 5j2tC-5nd4A:
54.1
5j2tC-5nd4A:
92.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ucy TUBULIN ALPHA CHAIN

(Tetrahymena
thermophila)
PF00091
(Tubulin)
PF03953
(Tubulin_C)
6 LEU A 248
VAL A 328
ASN A 329
ILE A 332
ALA A 333
GLY A 354
None
1.40A 5j2tC-5ucyA:
53.3
5j2tC-5ucyA:
85.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ucy TUBULIN ALPHA CHAIN

(Tetrahymena
thermophila)
PF00091
(Tubulin)
PF03953
(Tubulin_C)
6 LEU A 248
VAL A 328
ILE A 332
ALA A 333
GLY A 354
ILE A 355
None
1.29A 5j2tC-5ucyA:
53.3
5j2tC-5ucyA:
85.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ucy TUBULIN ALPHA CHAIN

(Tetrahymena
thermophila)
PF00091
(Tubulin)
PF03953
(Tubulin_C)
9 PRO A 325
VAL A 328
ASN A 329
ILE A 332
ALA A 333
LYS A 336
PHE A 351
VAL A 353
GLY A 354
None
0.94A 5j2tC-5ucyA:
53.3
5j2tC-5ucyA:
85.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ucy TUBULIN ALPHA CHAIN

(Tetrahymena
thermophila)
PF00091
(Tubulin)
PF03953
(Tubulin_C)
9 PRO A 325
VAL A 328
ILE A 332
ALA A 333
LYS A 336
PHE A 351
VAL A 353
GLY A 354
ILE A 355
None
0.96A 5j2tC-5ucyA:
53.3
5j2tC-5ucyA:
85.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wpk 3-HYDROXY-3-METHYLGL
UTARYL COENZYME A
REDUCTASE


(Streptococcus
pneumoniae)
no annotation 5 PRO A 122
LYS A 123
ILE A 129
ALA A 130
GLY A 203
None
0.76A 5j2tC-5wpkA:
undetectable
5j2tC-5wpkA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x8t PROTEIN L17

(Spinacia
oleracea)
PF01196
(Ribosomal_L17)
5 LYS O  56
VAL O  58
ILE O  62
LYS O  66
ILE O 123
G  W  76 ( 4.0A)
None
None
None
None
0.76A 5j2tC-5x8tO:
undetectable
5j2tC-5x8tO:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xxu RIBOSOMAL PROTEIN
US15


(Toxoplasma
gondii)
PF00312
(Ribosomal_S15)
PF08069
(Ribosomal_S13_N)
5 PRO N  30
VAL N  33
ILE N  37
ALA N  38
VAL N  63
None
0.58A 5j2tC-5xxuN:
undetectable
5j2tC-5xxuN:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6az1 RIBOSOMAL PROTEIN
S10E


(Leishmania
donovani)
no annotation 6 PRO N  76
VAL N  80
ILE N  54
ALA N  55
PHE N  48
VAL N  44
None
1.48A 5j2tC-6az1N:
undetectable
5j2tC-6az1N:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c49 ALCOHOL
DEHYDROGENASE


(Acinetobacter
baumannii)
no annotation 6 VAL A  35
ILE A  71
ALA A  73
VAL A  87
GLY A  88
ILE A  67
None
1.49A 5j2tC-6c49A:
undetectable
5j2tC-6c49A:
9.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c5b METHYLTRANSFERASE

(Lysobacter
antibioticus)
no annotation 5 LYS A  63
VAL A  65
ILE A  69
ALA A  70
VAL A  31
None
0.84A 5j2tC-6c5bA:
undetectable
5j2tC-6c5bA:
10.38