SIMILAR PATTERNS OF AMINO ACIDS FOR 5J2T_C_VLBC503
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1a0i | DNA LIGASE (Escherichiavirus T7) |
PF01068(DNA_ligase_A_M) | 5 | LYS A 97VAL A 96ASP A 100THR A 115LEU A 139 | None | 1.38A | 5j2tB-1a0iA:undetectable | 5j2tB-1a0iA:23.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1t61 | TYPE IV COLLAGEN (Bos taurus) |
PF01413(C4) | 5 | VAL A 36ASP A 78TYR A 35PHE A 173LEU A 33 | None CL A 810 (-4.9A)NoneNoneNone | 1.45A | 5j2tB-1t61A:undetectable | 5j2tB-1t61A:19.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2b39 | C3 (Bos taurus) |
PF00207(A2M)PF01759(NTR)PF01821(ANATO)PF01835(A2M_N)PF07677(A2M_recep)PF07678(A2M_comp)PF07703(A2M_N_2)PF10569(Thiol-ester_cl) | 5 | LYS A1083VAL A1081TYR A1080TYR A1065LEU A1077 | None | 1.36A | 5j2tB-2b39A:0.0 | 5j2tB-2b39A:14.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zab | ALGINATE LYASE (Sphingomonassp. A1) |
PF08787(Alginate_lyase2) | 5 | PHE A 89THR A 122PRO A 85TYR A 115LEU A 111 | GOL A 601 ( 4.6A)NoneNoneNoneNone | 1.49A | 5j2tB-2zabA:0.0 | 5j2tB-2zabA:18.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gmt | ADENYLATE KINASE (Burkholderiapseudomallei) |
PF00406(ADK)PF05191(ADK_lid) | 5 | VAL A 106ASP A 104TYR A 182PRO A 87LEU A 6 | None | 1.27A | 5j2tB-3gmtA:1.9 | 5j2tB-3gmtA:21.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kx6 | FRUCTOSE-BISPHOSPHATE ALDOLASE (Babesia bovis) |
PF00274(Glycolytic) | 5 | VAL A 105ASP A 31THR A 122TYR A 172LEU A 127 | None | 1.31A | 5j2tB-3kx6A:0.0 | 5j2tB-3kx6A:22.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3oc5 | TOXIN COREGULATEDPILUS BIOSYNTHESISPROTEIN F (Vibrio cholerae) |
PF06340(TcpF) | 5 | ASP A 97THR A 111PRO A 110TYR A 148LEU A 141 | None | 1.45A | 5j2tB-3oc5A:0.0 | 5j2tB-3oc5A:19.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vss | BETA-FRUCTOFURANOSIDASE (Microbacteriumsaccharophilum) |
PF02435(Glyco_hydro_68) | 5 | VAL A 136ASP A 138PHE A 470THR A 485TYR A 174 | None | 1.05A | 5j2tB-3vssA:0.0 | 5j2tB-3vssA:21.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4myr | CPAE2 PILUS ASSEMBLYPROTEIN (Sinorhizobiummeliloti) |
no annotation | 5 | VAL A 83ASP A 32THR A 107TYR A 74LEU A 101 | None | 1.28A | 5j2tB-4myrA:2.3 | 5j2tB-4myrA:16.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4n3n | EUKARYOTICTRANSLATIONINITIATION FACTOR5B-LIKE PROTEIN,EIF5B(517-C) (Chaetomiumthermophilum) |
PF00009(GTP_EFTU)PF03144(GTP_EFTU_D2)PF11987(IF-2) | 5 | VAL A 875ASP A 909PHE A 929THR A 879LEU A 887 | None | 1.31A | 5j2tB-4n3nA:2.0 | 5j2tB-4n3nA:22.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4np6 | ADENYLATE KINASE (Vibrio cholerae) |
PF00406(ADK)PF05191(ADK_lid) | 5 | VAL A 106ASP A 104TYR A 182PRO A 87LEU A 6 | None | 1.12A | 5j2tB-4np6A:3.0 | 5j2tB-4np6A:19.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bv9 | CELLULOSE1,4-BETA-CELLOBIOSIDASE (Bacilluspumilus) |
PF02011(Glyco_hydro_48) | 5 | LYS A 431VAL A 430ASP A 434TYR A 427PHE A 547 | ACT A 810 (-4.9A)NoneNoneNoneNone | 1.48A | 5j2tB-5bv9A:undetectable | 5j2tB-5bv9A:19.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kdj | F5/8 TYPE C DOMAINPROTEIN (Clostridiumperfringens) |
no annotation | 5 | VAL B 964PHE B 966THR B 988TYR B 985LEU B 940 | None | 1.44A | 5j2tB-5kdjB:undetectable | 5j2tB-5kdjB:20.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kds | F5/8 TYPE C DOMAINPROTEIN (Clostridiumperfringens) |
PF13402(Peptidase_M60) | 5 | VAL A 964PHE A 966THR A 988TYR A 985LEU A 940 | None | 1.44A | 5j2tB-5kdsA:undetectable | 5j2tB-5kdsA:20.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ae1 | TROPINONEREDUCTASE-I (Daturastramonium) |
PF13561(adh_short_C2) | 5 | PRO A 238VAL A 241ILE A 245ALA A 246ILE A 204 | NoneNoneNoneNoneNAP A 274 (-4.4A) | 0.82A | 5j2tC-1ae1A:7.3 | 5j2tC-1ae1A:21.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bu8 | PROTEIN (PANCREATICLIPASE RELATEDPROTEIN 2) (Rattusnorvegicus) |
PF00151(Lipase)PF01477(PLAT) | 6 | LEU A 153VAL A 124ILE A 128ALA A 129PHE A 72VAL A 74 | None | 0.93A | 5j2tC-1bu8A:4.5 | 5j2tC-1bu8A:20.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1czf | POLYGALACTURONASE II (Aspergillusniger) |
PF00295(Glyco_hydro_28) | 5 | VAL A 190ILE A 192PHE A 182VAL A 184GLY A 185 | None | 0.77A | 5j2tC-1czfA:undetectable | 5j2tC-1czfA:21.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dhs | DEOXYHYPUSINESYNTHASE (Homo sapiens) |
PF01916(DS) | 5 | LEU A 107VAL A 286ILE A 290ALA A 291PHE A 100 | NAD A 700 (-4.6A)NoneNoneNoneNone | 0.80A | 5j2tC-1dhsA:4.7 | 5j2tC-1dhsA:21.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gae | D-GLYCERALDEHYDE-3-PHOSPHATEDEHYDROGENASE (Escherichiacoli) |
PF00044(Gp_dh_N)PF02800(Gp_dh_C) | 6 | VAL O 321ILE O 325ALA O 326VAL O 15GLY O 12ILE O 11 | NoneNoneNoneNoneNoneNAD O 336 (-3.9A) | 1.36A | 5j2tC-1gaeO:2.4 | 5j2tC-1gaeO:21.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1iwl | OUTER-MEMBRANELIPOPROTEINS CARRIERPROTEIN (Escherichiacoli) |
PF03548(LolA) | 6 | ASN A 96ILE A 93ALA A 94PHE A 140VAL A 131GLY A 132 | NoneNoneNoneNoneNone ZN A 193 ( 4.6A) | 1.10A | 5j2tC-1iwlA:undetectable | 5j2tC-1iwlA:19.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jhs | MOG1 PROTEIN (Saccharomycescerevisiae) |
PF04603(Mog1) | 6 | VAL A 108ALA A 103PHE A 134VAL A 158GLY A 157ILE A 156 | None | 1.46A | 5j2tC-1jhsA:undetectable | 5j2tC-1jhsA:18.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1js1 | TRANSCARBAMYLASE (Bacteroidesfragilis) |
PF00185(OTCace)PF02729(OTCace_N) | 5 | LEU X 40ILE X 126VAL X 109GLY X 108ILE X 107 | None | 0.79A | 5j2tC-1js1X:undetectable | 5j2tC-1js1X:21.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jwq | N-ACETYLMURAMOYL-L-ALANINE AMIDASE CWLV (Paenibacilluspolymyxa) |
PF01520(Amidase_3) | 6 | LYS A 27ASN A 30ILE A 79ALA A 34VAL A 143GLY A 144 | None | 1.46A | 5j2tC-1jwqA:4.1 | 5j2tC-1jwqA:20.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1k5c | ENDOPOLYGALACTURONASE (Chondrostereumpurpureum) |
PF00295(Glyco_hydro_28) | 5 | VAL A 162ILE A 164PHE A 155VAL A 124GLY A 125 | None | 0.82A | 5j2tC-1k5cA:undetectable | 5j2tC-1k5cA:20.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kv9 | TYPE IIQUINOHEMOPROTEINALCOHOLDEHYDROGENASE (Pseudomonasputida) |
PF13360(PQQ_2)PF13442(Cytochrome_CBB3) | 6 | VAL A 246ILE A 275ALA A 274PHE A 194VAL A 180GLY A 168 | None | 1.41A | 5j2tC-1kv9A:undetectable | 5j2tC-1kv9A:21.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1n21 | (+)-BORNYLDIPHOSPHATE SYNTHASE (Salviaofficinalis) |
PF01397(Terpene_synth)PF03936(Terpene_synth_C) | 5 | LYS A 541ASN A 544ILE A 547ALA A 548ILE A 491 | None | 0.72A | 5j2tC-1n21A:undetectable | 5j2tC-1n21A:21.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1q18 | GLUCOKINASE (Escherichiacoli) |
PF02685(Glucokinase) | 5 | PRO A 193VAL A 196ASN A 197ALA A 201LYS A 204 | None | 0.52A | 5j2tC-1q18A:undetectable | 5j2tC-1q18A:21.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qn2 | CYTOCHROME CH (Methylobacteriumextorquens) |
PF00034(Cytochrom_C) | 5 | PRO A 86VAL A 89ILE A 93ALA A 94LYS A 97 | None | 0.36A | 5j2tC-1qn2A:undetectable | 5j2tC-1qn2A:14.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tc1 | PROTEIN(HYPOXANTHINEPHOSPHORIBOSYLTRANSFERASE) (Trypanosomacruzi) |
PF00156(Pribosyltran) | 5 | LEU A 140VAL A 25ILE A 29ALA A 30VAL A 138 | None | 0.79A | 5j2tC-1tc1A:3.4 | 5j2tC-1tc1A:21.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ulv | GLUCODEXTRANASE (Arthrobacterglobiformis) |
PF00723(Glyco_hydro_15)PF09136(Glucodextran_B)PF09137(Glucodextran_N)PF09985(Glucodextran_C) | 5 | VAL A 928ILE A 846PHE A 822VAL A 811GLY A 810 | None | 0.83A | 5j2tC-1ulvA:undetectable | 5j2tC-1ulvA:18.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vjn | ZN-DEPENDENTHYDROLASE OFMETALLO-BETA-LACTAMASE SUPERFAMILYTM0207 (Thermotogamaritima) |
PF13483(Lactamase_B_3) | 5 | ILE A 20ALA A 12PHE A 99VAL A 74GLY A 73 | None | 0.79A | 5j2tC-1vjnA:undetectable | 5j2tC-1vjnA:18.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vk1 | CONSERVEDHYPOTHETICAL PROTEIN (Pyrococcusfuriosus) |
PF02195(ParBc) | 5 | VAL A 110ASN A 111ILE A 114LYS A 118GLY A 145 | None | 0.82A | 5j2tC-1vk1A:undetectable | 5j2tC-1vk1A:17.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vlu | GAMMA-GLUTAMYLPHOSPHATE REDUCTASE (Saccharomycescerevisiae) |
PF00171(Aldedh) | 5 | VAL A 162ASN A 163ILE A 166ALA A 167ILE A 129 | None | 0.56A | 5j2tC-1vluA:undetectable | 5j2tC-1vluA:22.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vpe | PHOSPHOGLYCERATEKINASE (Thermotogamaritima) |
PF00162(PGK) | 5 | LYS A 333VAL A 335ILE A 339ALA A 340ILE A 296 | None | 0.82A | 5j2tC-1vpeA:undetectable | 5j2tC-1vpeA:23.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vpe | PHOSPHOGLYCERATEKINASE (Thermotogamaritima) |
PF00162(PGK) | 5 | LYS A 333VAL A 335ILE A 339ALA A 340VAL A 192 | None | 0.66A | 5j2tC-1vpeA:undetectable | 5j2tC-1vpeA:23.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1y1p | ALDEHYDE REDUCTASEII (Sporidiobolussalmonicolor) |
PF01370(Epimerase) | 5 | LEU A 33VAL A 17ILE A 91ALA A 92VAL A 28 | NoneNoneNMN A1001 (-4.9A)AMP A1002 (-3.7A)None | 0.77A | 5j2tC-1y1pA:5.2 | 5j2tC-1y1pA:21.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ytu | HYPOTHETICAL PROTEINAF1318 (Archaeoglobusfulgidus) |
PF02171(Piwi) | 5 | PRO A 394LYS A 395VAL A 397ILE A 401ALA A 402 | None | 0.57A | 5j2tC-1ytuA:undetectable | 5j2tC-1ytuA:20.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1z1w | TRICORN PROTEASEINTERACTING FACTORF3 (Thermoplasmaacidophilum) |
PF01433(Peptidase_M1)PF11838(ERAP1_C) | 6 | VAL A 125ILE A 123ALA A 122VAL A 165GLY A 166ILE A 167 | None | 1.42A | 5j2tC-1z1wA:undetectable | 5j2tC-1z1wA:19.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zpv | ACT DOMAIN PROTEIN (Streptococcuspneumoniae) |
PF13740(ACT_6) | 6 | LEU A 70VAL A 7ILE A 5VAL A 19GLY A 18ILE A 15 | None | 1.33A | 5j2tC-1zpvA:undetectable | 5j2tC-1zpvA:12.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2b67 | COG0778:NITROREDUCTASE (Streptococcuspneumoniae) |
PF00881(Nitroreductase) | 5 | PRO A 23VAL A 26ILE A 30PHE A 47VAL A 49 | None | 0.51A | 5j2tC-2b67A:undetectable | 5j2tC-2b67A:20.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bp5 | CLATHRIN COATASSEMBLY PROTEINAP50 (Rattusnorvegicus) |
PF00928(Adap_comp_sub) | 6 | LYS M 354VAL M 322ILE M 324ALA M 350VAL M 305ILE M 307 | None | 1.27A | 5j2tC-2bp5M:undetectable | 5j2tC-2bp5M:21.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2buf | ACETYLGLUTAMATEKINASE (Pseudomonasaeruginosa) |
PF00696(AA_kinase) | 5 | VAL A 239ASN A 240ILE A 243ALA A 244ILE A 295 | None | 0.83A | 5j2tC-2bufA:2.6 | 5j2tC-2bufA:20.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ilu | ALDEHYDEDEHYDROGENASE A (Escherichiacoli) |
PF00171(Aldedh) | 5 | ASN A 183ILE A 186ALA A 187LYS A 190ILE A 24 | None | 0.66A | 5j2tC-2iluA:undetectable | 5j2tC-2iluA:22.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2iq7 | ENDOPOLYGALACTURONASE (Colletotrichumlupini) |
PF00295(Glyco_hydro_28) | 5 | VAL A 188ILE A 190PHE A 180VAL A 182GLY A 183 | None | 0.69A | 5j2tC-2iq7A:undetectable | 5j2tC-2iq7A:20.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jk0 | L-ASPARAGINASE (Pectobacteriumcarotovorum) |
PF00710(Asparaginase) | 6 | LYS A 75VAL A 77ASN A 78ALA A 82VAL A 115ILE A 91 | None | 1.46A | 5j2tC-2jk0A:undetectable | 5j2tC-2jk0A:21.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pfk | 6-PHOSPHOFRUCTOKINASE ISOZYME I (Escherichiacoli) |
PF00365(PFK) | 5 | VAL A 23ALA A 18VAL A 6GLY A 5ILE A 4 | None | 0.81A | 5j2tC-2pfkA:undetectable | 5j2tC-2pfkA:21.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qo3 | ERYAII ERYTHROMYCINPOLYKETIDE SYNTHASEMODULES 3 AND 4 (Saccharopolysporaerythraea) |
PF00109(ketoacyl-synt)PF00698(Acyl_transf_1)PF02801(Ketoacyl-synt_C)PF16197(KAsynt_C_assoc) | 6 | LEU A 887PRO A 473ILE A 491ALA A 488VAL A 505GLY A 504 | None | 1.43A | 5j2tC-2qo3A:undetectable | 5j2tC-2qo3A:19.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2v7z | HEAT SHOCK COGNATE71 KDA PROTEIN (Rattusnorvegicus) |
PF00012(HSP70) | 5 | VAL A 238ASN A 239ILE A 242ALA A 243LYS A 246 | None | 0.72A | 5j2tC-2v7zA:undetectable | 5j2tC-2v7zA:22.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2v82 | 2-DEHYDRO-3-DEOXY-6-PHOSPHOGALACTONATEALDOLASE (Escherichiacoli) |
PF01081(Aldolase) | 6 | VAL A 36ILE A 38ALA A 64VAL A 25GLY A 26ILE A 29 | None | 1.30A | 5j2tC-2v82A:undetectable | 5j2tC-2v82A:19.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vbi | PYRUVATEDECARBOXYLASE (Acetobacterpasteurianus) |
PF00205(TPP_enzyme_M)PF02775(TPP_enzyme_C)PF02776(TPP_enzyme_N) | 5 | PRO A 507LYS A 508ILE A 514ALA A 515LYS A 518 | None | 0.68A | 5j2tC-2vbiA:2.3 | 5j2tC-2vbiA:22.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vj5 | PROTEIN MXIC (Shigellaflexneri) |
PF07201(HrpJ) | 5 | LYS A 155VAL A 157ASN A 158ILE A 161VAL A 122 | None | 0.82A | 5j2tC-2vj5A:undetectable | 5j2tC-2vj5A:20.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2x30 | PHOSPHORIBOSYLISOMERASE A (Streptomycescoelicolor) |
PF00977(His_biosynth) | 6 | LEU A 108VAL A 114ILE A 118ALA A 119VAL A 127GLY A 104 | NoneNoneNoneNoneNoneSO4 A1241 (-3.3A) | 1.39A | 5j2tC-2x30A:undetectable | 5j2tC-2x30A:19.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2x7x | SENSOR PROTEIN (Bacteroidesthetaiotaomicron) |
PF13407(Peripla_BP_4) | 6 | VAL A 143ILE A 147ALA A 148VAL A 245GLY A 246ILE A 247 | None | 1.17A | 5j2tC-2x7xA:undetectable | 5j2tC-2x7xA:22.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yjp | PUTATIVE ABCTRANSPORTER,PERIPLASMIC BINDINGPROTEIN, AMINO ACID (Neisseriagonorrhoeae) |
PF00497(SBP_bac_3) | 5 | VAL A 247ASN A 248ILE A 251ALA A 252LYS A 255 | None | 0.48A | 5j2tC-2yjpA:undetectable | 5j2tC-2yjpA:21.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zj4 | GLUCOSAMINE--FRUCTOSE-6-PHOSPHATEAMINOTRANSFERASE[ISOMERIZING] 1 (Homo sapiens) |
PF01380(SIS) | 5 | LEU A 419ILE A 362VAL A 443GLY A 444ILE A 445 | None | 0.73A | 5j2tC-2zj4A:3.9 | 5j2tC-2zj4A:21.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dnf | 4-HYDROXY-3-METHYLBUT-2-ENYL DIPHOSPHATEREDUCTASE (Aquifexaeolicus) |
PF02401(LYTB) | 5 | LYS A 173VAL A 175ILE A 179ALA A 180VAL A 144 | None | 0.83A | 5j2tC-3dnfA:undetectable | 5j2tC-3dnfA:20.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hvy | CYSTATHIONINEBETA-LYASE FAMILYPROTEIN, YNBBB.SUBTILIS ORTHOLOG (Clostridiumacetobutylicum) |
PF06838(Met_gamma_lyase) | 6 | VAL A 216ILE A 237ALA A 238PHE A 86GLY A 233ILE A 202 | None | 1.24A | 5j2tC-3hvyA:2.7 | 5j2tC-3hvyA:21.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jzl | PUTATIVECYSTATHIONINEBETA-LYASE INVOLVEDIN ALUMINUMRESISTANCE (Listeriamonocytogenes) |
PF06838(Met_gamma_lyase) | 6 | VAL A 199ILE A 220ALA A 221PHE A 71GLY A 216ILE A 185 | None | 1.31A | 5j2tC-3jzlA:4.0 | 5j2tC-3jzlA:21.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l2e | GLYCOCYAMINE KINASEALPHA CHAIN (Namalycastissp. ST01) |
PF00217(ATP-gua_Ptrans)PF02807(ATP-gua_PtransN) | 6 | VAL A 368ASN A 369ILE A 372ALA A 373LYS A 376VAL A 137 | None | 0.80A | 5j2tC-3l2eA:undetectable | 5j2tC-3l2eA:22.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lm7 | PUTATIVE4-HYDROXY-2-OXOGLUTARATE ALDOLASE /2-DEHYDRO-3-DEOXYPHOSPHOGLUCONATEALDOLASE (Yersiniaenterocolitica) |
PF07071(KDGP_aldolase) | 5 | VAL A 144ILE A 148ALA A 149LYS A 152PHE A 185 | None | 0.84A | 5j2tC-3lm7A:undetectable | 5j2tC-3lm7A:19.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lpp | SUCRASE-ISOMALTASE (Homo sapiens) |
PF00088(Trefoil)PF01055(Glyco_hydro_31)PF16863(NtCtMGAM_N) | 5 | LEU A 881ILE A 827PHE A 842VAL A 845ILE A 847 | None | 0.78A | 5j2tC-3lppA:undetectable | 5j2tC-3lppA:18.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nzr | 2-DEHYDRO-3-DEOXYPHOSPHOGLUCONATEALDOLASE (Aliivibriofischeri) |
PF07071(KDGP_aldolase) | 5 | VAL A 144ILE A 148ALA A 149LYS A 152PHE A 185 | None | 0.80A | 5j2tC-3nzrA:undetectable | 5j2tC-3nzrA:17.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pqv | RCL1 PROTEIN (Kluyveromyceslactis) |
PF01137(RTC)PF05189(RTC_insert) | 5 | PRO A 201VAL A 204ASN A 205ILE A 208LYS A 212 | None | 0.73A | 5j2tC-3pqvA:undetectable | 5j2tC-3pqvA:21.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3r4v | PUTATIVEUNCHARACTERIZEDPROTEIN (Pseudomonasphage 201phi2-1) |
PF00091(Tubulin) | 5 | ASN A 165ILE A 168ALA A 169VAL A 118GLY A 119 | GDP A 400 (-2.9A)NoneNoneGDP A 400 (-4.6A)None | 0.77A | 5j2tC-3r4vA:19.7 | 5j2tC-3r4vA:21.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3r79 | UNCHARACTERIZEDPROTEIN (Agrobacteriumfabrum) |
PF01168(Ala_racemase_N) | 6 | VAL A 11ILE A 15ALA A 16VAL A 212GLY A 213ILE A 216 | None | 1.48A | 5j2tC-3r79A:undetectable | 5j2tC-3r79A:20.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ro8 | ENDO-1,4-BETA-XYLANASE (Paenibacillussp. JDR-2) |
PF00331(Glyco_hydro_10) | 6 | VAL A 209ILE A 205ALA A 204LYS A 201VAL A 229GLY A 228 | None | 1.20A | 5j2tC-3ro8A:undetectable | 5j2tC-3ro8A:20.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wiq | KOJIBIOSEPHOSPHORYLASE (Caldicellulosiruptorsaccharolyticus) |
PF03632(Glyco_hydro_65m)PF03633(Glyco_hydro_65C)PF03636(Glyco_hydro_65N) | 5 | LEU A 187PRO A 69VAL A 198GLY A 199ILE A 200 | None | 0.58A | 5j2tC-3wiqA:undetectable | 5j2tC-3wiqA:19.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zt9 | SERINE PHOSPHATASE (Moorellathermoacetica) |
PF07228(SpoIIE) | 5 | VAL A 25ILE A 32VAL A 6GLY A 7ILE A 8 | None | 0.55A | 5j2tC-3zt9A:undetectable | 5j2tC-3zt9A:17.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a3s | 6-PHOSPHOFRUCTOKINASE (Bacillussubtilis) |
PF00365(PFK) | 5 | VAL A 23ALA A 18VAL A 6GLY A 5ILE A 4 | None | 0.80A | 5j2tC-4a3sA:undetectable | 5j2tC-4a3sA:21.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ae0 | DIPHTHERIA TOXIN (Corynebacteriumdiphtheriae) |
PF01324(Diphtheria_R)PF02763(Diphtheria_C)PF02764(Diphtheria_T) | 5 | LEU A 434ILE A 420VAL A 511GLY A 510ILE A 509 | None | 0.77A | 5j2tC-4ae0A:undetectable | 5j2tC-4ae0A:21.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ci0 | F420-REDUCINGHYDROGENASE, SUBUNITBETA (Methanothermobactermarburgensis) |
PF04422(FrhB_FdhB_N)PF04432(FrhB_FdhB_C) | 5 | VAL C 29ALA C 34VAL C 130GLY C 131ILE C 132 | FAD C1283 (-4.0A)NoneNoneNoneFAD C1283 (-3.6A) | 0.79A | 5j2tC-4ci0C:undetectable | 5j2tC-4ci0C:20.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fk9 | CELLULOSE-BINDINGFAMILY II (Streptomycessp. SirexAA-E) |
PF00150(Cellulase) | 5 | PRO A 114VAL A 117ILE A 121ALA A 122LYS A 125 | None | 0.50A | 5j2tC-4fk9A:undetectable | 5j2tC-4fk9A:21.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fxt | UNCHARACTERIZEDPROTEIN (Bacteroidesovatus) |
PF12866(DUF3823) | 6 | LEU A 171ILE A 140PHE A 120VAL A 152GLY A 153ILE A 154 | None | 1.35A | 5j2tC-4fxtA:undetectable | 5j2tC-4fxtA:18.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4g1k | TRIOSEPHOSPHATEISOMERASE (Burkholderiathailandensis) |
PF00121(TIM) | 5 | VAL A 29ALA A 24VAL A 44GLY A 43ILE A 42 | None | 0.82A | 5j2tC-4g1kA:undetectable | 5j2tC-4g1kA:19.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4g6j | LIGHT CHAIN OFANTIBODY BINDINGFRAGMENT OFCANAKINUMAB (Homo sapiens) |
PF07654(C1-set)PF07686(V-set) | 6 | LEU L 73VAL L 104ILE L 106ALA L 80VAL L 19ILE L 21 | None | 1.45A | 5j2tC-4g6jL:undetectable | 5j2tC-4g6jL:20.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4h16 | SHORT CHAIN ALCOHOLDEHYDROGENASE-RELATED DEHYDROGENASE (Sinorhizobiummeliloti) |
PF13561(adh_short_C2) | 5 | PRO A 226VAL A 229ILE A 233ALA A 234ILE A 184 | None | 0.78A | 5j2tC-4h16A:7.2 | 5j2tC-4h16A:21.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hwi | HEAT SHOCK COGNATE71 KDA PROTEIN (Homo sapiens) |
PF00012(HSP70) | 6 | VAL A 238ASN A 239ILE A 242ALA A 243LYS A 246VAL A 260 | None | 1.11A | 5j2tC-4hwiA:undetectable | 5j2tC-4hwiA:22.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4i4i | 6-PHOSPHOFRUCTOKINASE (Geobacillusstearothermophilus) |
PF00365(PFK) | 6 | LEU A 275VAL A 23ILE A 20ALA A 18VAL A 6ILE A 4 | None | 1.32A | 5j2tC-4i4iA:undetectable | 5j2tC-4i4iA:22.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4i4i | 6-PHOSPHOFRUCTOKINASE (Geobacillusstearothermophilus) |
PF00365(PFK) | 6 | VAL A 23ILE A 20ALA A 18VAL A 6GLY A 5ILE A 4 | None | 0.97A | 5j2tC-4i4iA:undetectable | 5j2tC-4i4iA:22.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4i7z | APOCYTOCHROME F (Mastigocladuslaminosus) |
PF01333(Apocytochr_F_C)PF16639(Apocytochr_F_N) | 5 | LEU C 41PRO C 252VAL C 255ILE C 259ALA C 260 | NoneNoneNoneNoneOZ2 C 303 ( 4.3A) | 0.82A | 5j2tC-4i7zC:undetectable | 5j2tC-4i7zC:18.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4iiw | LMO1499 PROTEIN (Listeriamonocytogenes) |
PF02618(YceG) | 6 | LEU A 179LYS A 206ILE A 212ALA A 213PHE A 229GLY A 181 | None | 0.96A | 5j2tC-4iiwA:undetectable | 5j2tC-4iiwA:22.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jqp | 4-HYDROXYTHREONINE-4-PHOSPHATEDEHYDROGENASE (Paraburkholderiaphymatum) |
PF04166(PdxA) | 5 | LEU A 274ILE A 240VAL A 218GLY A 217ILE A 216 | None | 0.80A | 5j2tC-4jqpA:undetectable | 5j2tC-4jqpA:21.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ke4 | HYDROXYCINNAMOYL-COA:SHIKIMATEHYDROXYCINNAMOYLTRANSFERASE (Sorghum bicolor) |
PF02458(Transferase) | 6 | LEU A 252LYS A 243VAL A 429ILE A 431ALA A 240VAL A 277 | None | 1.28A | 5j2tC-4ke4A:undetectable | 5j2tC-4ke4A:23.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kg7 | PEPTIDASE S8 ANDS53, SUBTILISIN,KEXIN, SEDOLISIN (Mycolicibacteriumsmegmatis) |
PF00082(Peptidase_S8) | 6 | LEU A 353PRO A 392VAL A 390ILE A 305ALA A 387GLY A 349 | None | 1.40A | 5j2tC-4kg7A:undetectable | 5j2tC-4kg7A:24.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4n77 | UNCHARACTERIZEDPROTEIN (Thermusthermophilus) |
PF09704(Cas_Cas5d) | 5 | LEU A 4VAL A 35PHE A 126VAL A 128GLY A 129 | None | 0.57A | 5j2tC-4n77A:undetectable | 5j2tC-4n77A:20.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4p8r | GLYCERALDEHYDE3-PHOSPHATEDEHYDROGENASE,CYTOSOLIC (Trypanosomabrucei) |
PF00044(Gp_dh_N)PF02800(Gp_dh_C) | 6 | LYS A 321VAL A 322ILE A 326ALA A 327VAL A 94ILE A 13 | NoneNoneNoneNoneNoneNAD A 400 (-4.3A) | 1.33A | 5j2tC-4p8rA:undetectable | 5j2tC-4p8rA:20.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pj1 | 60 KDA HEAT SHOCKPROTEIN,MITOCHONDRIAL (Homo sapiens) |
PF00118(Cpn60_TCP1) | 5 | VAL A 124ILE A 128ALA A 129LYS A 132GLY A 510 | None | 0.69A | 5j2tC-4pj1A:undetectable | 5j2tC-4pj1A:23.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qcc | 2-DEHYDRO-3-DEOXY-6-PHOSPHOGALACTONATEALDOLASE,PEPTIDYL-PROLYLCIS-TRANS ISOMERASECHIMERA (Escherichiacoli) |
PF01081(Aldolase)PF01346(FKBP_N) | 6 | VAL A 36ILE A 38ALA A 64VAL A 25GLY A 26ILE A 29 | None | 1.30A | 5j2tC-4qccA:undetectable | 5j2tC-4qccA:19.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r9v | SIALYLTRANSFERASE0160 (Photobacteriumdamselae) |
PF11477(PM0188) | 6 | VAL A 375ASN A 379ILE A 378ALA A 381GLY A 413ILE A 410 | None | 1.45A | 5j2tC-4r9vA:5.6 | 5j2tC-4r9vA:22.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ry9 | PERIPLASMIC BINDINGPROTEIN/LACITRANSCRIPTIONALREGULATOR (Verminephrobactereiseniae) |
PF13407(Peripla_BP_4) | 5 | LEU A 94ALA A 52VAL A 40GLY A 39ILE A 38 | None | 0.74A | 5j2tC-4ry9A:4.0 | 5j2tC-4ry9A:21.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4u28 | PHOSPHORIBOSYLISOMERASE A (Streptomycessviceus) |
PF00977(His_biosynth) | 6 | LEU A 112VAL A 118ILE A 122ALA A 123VAL A 131GLY A 108 | NoneNoneNoneNoneNonePO4 A 302 (-3.3A) | 1.42A | 5j2tC-4u28A:undetectable | 5j2tC-4u28A:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ymx | ABC-TYPE AMINO ACIDTRANSPORT SYSTEM,PERIPLASMICCOMPONENT (Caldanaerobactersubterraneus) |
PF00497(SBP_bac_3) | 5 | VAL A 237ASN A 238ILE A 241LYS A 245VAL A 224 | None | 0.70A | 5j2tC-4ymxA:undetectable | 5j2tC-4ymxA:21.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z42 | UREASE SUBUNIT ALPHA (Yersiniaenterocolitica) |
PF00449(Urease_alpha)PF01979(Amidohydro_1) | 5 | LEU C 70ILE C 77VAL C 89GLY C 90ILE C 91 | None | 0.70A | 5j2tC-4z42C:2.3 | 5j2tC-4z42C:22.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5c5h | 2-SUCCINYLBENZOATE--COA LIGASE (Escherichiacoli) |
PF00501(AMP-binding)PF13193(AMP-binding_C) | 5 | PRO A 364VAL A 367ILE A 371ALA A 372ILE A 362 | None | 0.79A | 5j2tC-5c5hA:undetectable | 5j2tC-5c5hA:21.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5eaw | DNA REPLICATIONATP-DEPENDENTHELICASE/NUCLEASEDNA2 (Mus musculus) |
PF08696(Dna2)PF13086(AAA_11)PF13087(AAA_12) | 5 | LEU A 978ILE A 951VAL A 940GLY A 939ILE A 938 | None | 0.76A | 5j2tC-5eawA:undetectable | 5j2tC-5eawA:17.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5evl | BETA-LACTAMASE (Chromobacteriumviolaceum) |
PF00144(Beta-lactamase) | 5 | LEU A 327VAL A 360VAL A 334GLY A 335ILE A 336 | None | 0.79A | 5j2tC-5evlA:undetectable | 5j2tC-5evlA:22.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h3h | ABHYDROLASEDOMAIN-CONTAININGPROTEIN (Exiguobacteriumantarcticum) |
PF00561(Abhydrolase_1)PF08386(Abhydrolase_4) | 6 | VAL A 81ILE A 13ALA A 7VAL A 54GLY A 53ILE A 52 | None | 1.41A | 5j2tC-5h3hA:4.4 | 5j2tC-5h3hA:21.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5inw | PUTATIVEANGIOTENSINOGEN (Lampetrafluviatilis) |
PF00079(Serpin) | 6 | LEU A 239VAL A 119ALA A 113VAL A 413GLY A 414ILE A 415 | None | 1.23A | 5j2tC-5inwA:undetectable | 5j2tC-5inwA:18.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m2n | ELONGATOR COMPLEXPROTEIN 2 (Saccharomycescerevisiae) |
PF00400(WD40) | 6 | PRO A 751VAL A 773ILE A 391ALA A 402GLY A 723ILE A 729 | None | 1.38A | 5j2tC-5m2nA:undetectable | 5j2tC-5m2nA:19.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mdn | DNA POLYMERASE (Pyrobaculumcalidifontis) |
PF00136(DNA_pol_B)PF03104(DNA_pol_B_exo1) | 6 | LEU A 608VAL A 638ILE A 758ALA A 755GLY A 607ILE A 614 | None | 1.28A | 5j2tC-5mdnA:undetectable | 5j2tC-5mdnA:21.38 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5mjs | TUBULIN ALPHA-1CHAIN (Schizosaccharomycespombe) |
no annotation | 5 | PRO E 329VAL E 332PHE E 355GLY E 358ILE E 359 | None | 0.78A | 5j2tC-5mjsE:53.3 | 5j2tC-5mjsE:68.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5n28 | METHYL-COENZYME MREDUCTASE SUBUNITALPHA (Methanotorrisformicicus) |
PF02249(MCR_alpha)PF02745(MCR_alpha_N) | 5 | PRO A 367VAL A 371ILE A 375ALA A 376GLY A 364 | None | 0.82A | 5j2tC-5n28A:undetectable | 5j2tC-5n28A:21.72 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5nd4 | TUBULIN ALPHA CHAIN (Bos taurus) |
PF00091(Tubulin)PF03953(Tubulin_C) | 8 | PRO A 325VAL A 328ASN A 329ILE A 332ALA A 333PHE A 351GLY A 354ILE A 355 | None | 1.01A | 5j2tC-5nd4A:54.1 | 5j2tC-5nd4A:92.92 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5nd4 | TUBULIN ALPHA CHAIN (Bos taurus) |
PF00091(Tubulin)PF03953(Tubulin_C) | 8 | PRO A 325VAL A 328ILE A 332ALA A 333PHE A 351VAL A 353GLY A 354ILE A 355 | None | 1.01A | 5j2tC-5nd4A:54.1 | 5j2tC-5nd4A:92.92 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5ucy | TUBULIN ALPHA CHAIN (Tetrahymenathermophila) |
PF00091(Tubulin)PF03953(Tubulin_C) | 6 | LEU A 248VAL A 328ASN A 329ILE A 332ALA A 333GLY A 354 | None | 1.40A | 5j2tC-5ucyA:53.3 | 5j2tC-5ucyA:85.97 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5ucy | TUBULIN ALPHA CHAIN (Tetrahymenathermophila) |
PF00091(Tubulin)PF03953(Tubulin_C) | 6 | LEU A 248VAL A 328ILE A 332ALA A 333GLY A 354ILE A 355 | None | 1.29A | 5j2tC-5ucyA:53.3 | 5j2tC-5ucyA:85.97 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5ucy | TUBULIN ALPHA CHAIN (Tetrahymenathermophila) |
PF00091(Tubulin)PF03953(Tubulin_C) | 9 | PRO A 325VAL A 328ASN A 329ILE A 332ALA A 333LYS A 336PHE A 351VAL A 353GLY A 354 | None | 0.94A | 5j2tC-5ucyA:53.3 | 5j2tC-5ucyA:85.97 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5ucy | TUBULIN ALPHA CHAIN (Tetrahymenathermophila) |
PF00091(Tubulin)PF03953(Tubulin_C) | 9 | PRO A 325VAL A 328ILE A 332ALA A 333LYS A 336PHE A 351VAL A 353GLY A 354ILE A 355 | None | 0.96A | 5j2tC-5ucyA:53.3 | 5j2tC-5ucyA:85.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wpk | 3-HYDROXY-3-METHYLGLUTARYL COENZYME AREDUCTASE (Streptococcuspneumoniae) |
no annotation | 5 | PRO A 122LYS A 123ILE A 129ALA A 130GLY A 203 | None | 0.76A | 5j2tC-5wpkA:undetectable | 5j2tC-5wpkA:11.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x8t | PROTEIN L17 (Spinaciaoleracea) |
PF01196(Ribosomal_L17) | 5 | LYS O 56VAL O 58ILE O 62LYS O 66ILE O 123 | G W 76 ( 4.0A)NoneNoneNoneNone | 0.76A | 5j2tC-5x8tO:undetectable | 5j2tC-5x8tO:11.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xxu | RIBOSOMAL PROTEINUS15 (Toxoplasmagondii) |
PF00312(Ribosomal_S15)PF08069(Ribosomal_S13_N) | 5 | PRO N 30VAL N 33ILE N 37ALA N 38VAL N 63 | None | 0.58A | 5j2tC-5xxuN:undetectable | 5j2tC-5xxuN:15.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6az1 | RIBOSOMAL PROTEINS10E (Leishmaniadonovani) |
no annotation | 6 | PRO N 76VAL N 80ILE N 54ALA N 55PHE N 48VAL N 44 | None | 1.48A | 5j2tC-6az1N:undetectable | 5j2tC-6az1N:10.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6c49 | ALCOHOLDEHYDROGENASE (Acinetobacterbaumannii) |
no annotation | 6 | VAL A 35ILE A 71ALA A 73VAL A 87GLY A 88ILE A 67 | None | 1.49A | 5j2tC-6c49A:undetectable | 5j2tC-6c49A:9.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6c5b | METHYLTRANSFERASE (Lysobacterantibioticus) |
no annotation | 5 | LYS A 63VAL A 65ILE A 69ALA A 70VAL A 31 | None | 0.84A | 5j2tC-6c5bA:undetectable | 5j2tC-6c5bA:10.38 |