SIMILAR PATTERNS OF AMINO ACIDS FOR 5IZJ_G_AZ1G2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gng GLYCOGEN SYNTHASE
KINASE-3 BETA

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLY A  63
GLY A  65
SER A  66
VAL A  70
LYS A  85
 None
 0.72A 5izjA-1gngA:
24.9		 5izjA-1gngA:
23.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gzk RAC-BETA
SERINE/THREONINE
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		5 GLY A 159
GLY A 161
VAL A 166
LYS A 181
LEU A 183
 None
 0.32A 5izjA-1gzkA:
30.1		 5izjA-1gzkA:
39.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1koa TWITCHIN

(Caenorhabditis
elegans) 		PF00069
(Pkinase)
PF07679
(I-set) 		5 GLY A5949
GLY A5951
PHE A5953
VAL A5956
LYS A5971
 None
 0.92A 5izjA-1koaA:
19.2		 5izjA-1koaA:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kob TWITCHIN

(Aplysia
californica) 		PF00069
(Pkinase) 		4 GLY A  60
GLY A  62
VAL A  67
LYS A  82
 None
 0.43A 5izjA-1kobA:
25.5		 5izjA-1kobA:
26.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m2p CASEIN KINASE II,
ALPHA CHAIN

(Zea mays) 		PF00069
(Pkinase) 		4 GLY A  46
GLY A  48
VAL A  53
LYS A  68
 HNA  A 351 (-2.8A)
HNA  A 351 ( 4.6A)
HNA  A 351 (-4.5A)
HNA  A 351 (-2.6A)
 0.44A 5izjA-1m2pA:
24.6		 5izjA-1m2pA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tki TITIN

(Homo sapiens) 		PF00069
(Pkinase) 		4 GLY A  31
GLY A  33
VAL A  38
LYS A  53
 None
 0.46A 5izjA-1tkiA:
19.6		 5izjA-1tkiA:
25.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5q SERINE/THREONINE
PROTEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		5 GLY A  35
GLY A  37
SER A  38
VAL A  42
LYS A  57
 None
 0.68A 5izjA-1u5qA:
28.0		 5izjA-1u5qA:
25.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1zrz PROTEIN KINASE C,
IOTA

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		4 GLY A 252
GLY A 254
VAL A 259
LYS A 274
 BI1  A1000 (-3.6A)
None
BI1  A1000 (-4.2A)
BI1  A1000 (-3.5A)
 0.37A 5izjA-1zrzA:
36.8		 5izjA-1zrzA:
34.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		4 GLY A  20
GLY A  22
VAL A  27
LYS A  42
 None
 0.33A 5izjA-2a2aA:
28.2		 5izjA-2a2aA:
27.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eu9 DUAL SPECIFICITY
PROTEIN KINASE CLK3

(Homo sapiens) 		PF00069
(Pkinase) 		4 GLY A 163
GLY A 165
VAL A 170
LYS A 186
 None
 0.43A 5izjA-2eu9A:
25.8		 5izjA-2eu9A:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		4 GLY A  20
GLY A  22
VAL A  27
LYS A  42
 ADP  A 500 ( 4.1A)
ADP  A 500 ( 4.6A)
ADP  A 500 (-4.3A)
ADP  A 500 (-2.9A)
 0.32A 5izjA-2f9gA:
16.2		 5izjA-2f9gA:
26.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		4 GLY A 274
GLY A 276
VAL A 281
LEU A 297
 H8H  A 534 ( 3.8A)
None
H8H  A 534 (-4.4A)
None
 0.49A 5izjA-2h8hA:
21.7		 5izjA-2h8hA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 GLY A 252
GLY A 254
VAL A 259
LYS A 273
 None
None
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.8A)
 0.46A 5izjA-2hk5A:
18.9		 5izjA-2hk5A:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hw6 MAP
KINASE-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		4 GLY A  56
GLY A  58
VAL A  63
LYS A  78
 None
 0.29A 5izjA-2hw6A:
22.0		 5izjA-2hw6A:
28.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 GLY A 249
GLY A 251
VAL A 256
LYS A 271
 None
None
GIN  A 600 ( 4.7A)
GIN  A 600 (-3.6A)
 0.43A 5izjA-2hz0A:
22.8		 5izjA-2hz0A:
24.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2i0e PROTEIN KINASE
C-BETA II

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		5 GLY A 349
GLY A 351
VAL A 356
LYS A 371
LEU A 373
 PDS  A 901 ( 3.7A)
None
PDS  A 901 (-4.2A)
PDS  A 901 ( 4.5A)
None
 0.75A 5izjA-2i0eA:
25.5		 5izjA-2i0eA:
36.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2jam CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1G

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLY A  30
GLY A  32
PHE A  34
VAL A  37
LYS A  52
 None
None
None
J60  A1305 (-4.8A)
EDO  A1304 ( 2.9A)
 0.33A 5izjA-2jamA:
20.0		 5izjA-2jamA:
30.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2jc6 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1D

(Homo sapiens) 		PF00069
(Pkinase) 		4 GLY A  30
GLY A  32
VAL A  37
LYS A  52
 QPP  A1314 ( 3.7A)
None
QPP  A1314 ( 4.6A)
None
 0.20A 5izjA-2jc6A:
17.7		 5izjA-2jc6A:
31.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2v55 RHO-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLY A  83
GLY A  85
VAL A  90
LYS A 105
LEU A 107
 ANP  A1480 ( 4.3A)
ANP  A1480 ( 3.8A)
None
ANP  A1480 (-3.4A)
None
 0.47A 5izjA-2v55A:
27.0		 5izjA-2v55A:
35.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vuw SERINE/THREONINE-PRO
TEIN KINASE HASPIN

(Homo sapiens) 		PF12330
(Haspin_kinase) 		4 GLY A 491
GLY A 493
VAL A 498
LYS A 511
 5ID  A1800 (-3.5A)
None
5ID  A1800 ( 4.5A)
IOD  A1799 (-3.2A)
 0.45A 5izjA-2vuwA:
15.7		 5izjA-2vuwA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV

(Homo sapiens) 		PF00069
(Pkinase) 		4 GLY A  53
GLY A  55
VAL A  60
LYS A  75
 DKI  A1338 (-3.3A)
None
DKI  A1338 (-4.2A)
None
 0.31A 5izjA-2w4oA:
22.0		 5izjA-2w4oA:
29.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtk SERINE/THREONINE-PRO
TEIN KINASE 11

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLY C  56
GLY C  58
SER C  59
VAL C  63
LYS C  78
 ANP  C   2 (-3.3A)
ANP  C   2 (-3.0A)
None
ANP  C   2 (-4.2A)
ANP  C   2 (-3.6A)
 0.89A 5izjA-2wtkC:
30.0		 5izjA-2wtkC:
28.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyu EPHRIN TYPE-A
RECEPTOR 4,

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		4 GLY A 628
GLY A 630
VAL A 635
LYS A 653
 None
None
Q9G  A1898 ( 4.7A)
Q9G  A1898 (-4.8A)
 0.42A 5izjA-2xyuA:
22.5		 5izjA-2xyuA:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yab DEATH-ASSOCIATED
PROTEIN KINASE 2

(Mus musculus) 		PF00069
(Pkinase) 		4 GLY A  20
GLY A  22
VAL A  27
LYS A  42
 AMP  A1302 (-3.5A)
AMP  A1302 ( 4.6A)
AMP  A1302 (-4.2A)
AMP  A1302 (-2.8A)
 0.47A 5izjA-2yabA:
28.0		 5izjA-2yabA:
26.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bqr DEATH-ASSOCIATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		4 GLY A  20
GLY A  22
VAL A  27
LYS A  42
 4RB  A 401 (-3.6A)
None
4RB  A 401 ( 4.4A)
4RB  A 401 ( 2.8A)
 0.37A 5izjA-3bqrA:
19.3		 5izjA-3bqrA:
26.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c0i PERIPHERAL PLASMA
MEMBRANE PROTEIN
CASK

(Homo sapiens) 		PF00069
(Pkinase) 		4 GLY A  19
GLY A  21
VAL A  26
LYS A  41
 None
None
3AM  A 338 ( 4.1A)
3AM  A 338 (-2.9A)
 0.22A 5izjA-3c0iA:
21.8		 5izjA-3c0iA:
28.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e7o MITOGEN-ACTIVATED
PROTEIN KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		4 GLY A  33
GLY A  35
VAL A  40
LYS A  55
 35F  A   1 ( 4.8A)
None
35F  A   1 ( 4.8A)
35F  A   1 ( 4.6A)
 0.32A 5izjA-3e7oA:
23.5		 5izjA-3e7oA:
26.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fhh OUTER MEMBRANE HEME
RECEPTOR SHUA

(Shigella
dysenteriae) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 GLY A 143
GLY A 145
VAL A 636
LEU A 609
 None
 0.36A 5izjA-3fhhA:
undetectable		 5izjA-3fhhA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 GLY A 834
GLY A 836
VAL A 841
LYS A 861
 None
None
8ST  A2001 ( 4.6A)
8ST  A2001 (-4.0A)
 0.48A 5izjA-3hngA:
22.2		 5izjA-3hngA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l9y SUPEROXIDE DISMUTASE
[CU-ZN]

(Bombyx mori) 		PF00080
(Sod_Cu) 		5 GLY A  32
GLY A  15
SER A  14
VAL A  97
LEU A  37
 None
 1.37A 5izjA-3l9yA:
undetectable		 5izjA-3l9yA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lzb EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 GLY A 695
GLY A 697
VAL A 702
LYS A 721
 ITI  A   1 ( 4.8A)
None
ITI  A   1 (-4.8A)
ITI  A   1 (-2.6A)
 0.44A 5izjA-3lzbA:
20.2		 5izjA-3lzbA:
22.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLY A  50
GLY A  52
SER A  53
VAL A  57
LYS A  72
 XFE  A 351 ( 4.0A)
None
None
XFE  A 351 ( 4.5A)
None
 0.69A 5izjA-3mvjA:
47.9		 5izjA-3mvjA:
94.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLY A  50
GLY A  52
VAL A  57
LYS A  72
LEU A  74
 XFE  A 351 ( 4.0A)
None
XFE  A 351 ( 4.5A)
None
None
 0.48A 5izjA-3mvjA:
47.9		 5izjA-3mvjA:
94.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 GLY A 209
GLY A 211
VAL A 216
LYS A 229
 None
None
LDN  A 600 (-4.5A)
LDN  A 600 (-4.0A)
 0.35A 5izjA-3my0A:
21.4		 5izjA-3my0A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		4 GLY A 193
VAL A 200
LYS A 215
LEU A 217
 AMP  A 577 ( 3.7A)
AMP  A 577 (-4.3A)
AMP  A 577 (-2.8A)
None
 0.44A 5izjA-3nyoA:
36.3		 5izjA-3nyoA:
26.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3o96 RAC-ALPHA
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase)
PF00169
(PH) 		5 GLY A 157
GLY A 159
VAL A 164
LYS A 179
LEU A 181
 GLY  A 157 ( 0.0A)
GLY  A 159 ( 0.0A)
VAL  A 164 ( 0.6A)
LYS  A 179 ( 0.0A)
LEU  A 181 ( 0.6A)
 0.38A 5izjA-3o96A:
30.3		 5izjA-3o96A:
34.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		5 GLY A 558
GLY A 560
SER A 561
VAL A 565
LEU A 580
 STU  A   1 (-3.2A)
None
None
STU  A   1 (-4.9A)
None
 0.66A 5izjA-3ppzA:
26.3		 5izjA-3ppzA:
26.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		5 GLY A 558
GLY A 560
VAL A 565
LYS A 578
LEU A 580
 STU  A   1 (-3.2A)
None
STU  A   1 (-4.9A)
STU  A   1 (-3.5A)
None
 0.81A 5izjA-3ppzA:
26.3		 5izjA-3ppzA:
26.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3qfv CDC42BPB PROTEIN

(Homo sapiens) 		PF00069
(Pkinase) 		4 GLY A  83
VAL A  90
LYS A 105
LEU A 107
 NM7  A 416 (-3.0A)
NM7  A 416 (-3.7A)
EDO  A 417 (-3.5A)
EDO  A 417 (-4.6A)
 0.45A 5izjA-3qfvA:
26.9		 5izjA-3qfvA:
33.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3txo PROTEIN KINASE C ETA
TYPE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		5 GLY A 362
GLY A 364
SER A 365
VAL A 369
LYS A 384
 07U  A   1 ( 4.2A)
None
None
07U  A   1 (-4.8A)
07U  A   1 (-3.0A)
 0.83A 5izjA-3txoA:
33.3		 5izjA-3txoA:
39.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3txo PROTEIN KINASE C ETA
TYPE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		5 GLY A 362
GLY A 364
VAL A 369
LYS A 384
LEU A 386
 07U  A   1 ( 4.2A)
None
07U  A   1 (-4.8A)
07U  A   1 (-3.0A)
None
 0.46A 5izjA-3txoA:
33.3		 5izjA-3txoA:
39.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uto TWITCHIN

(Caenorhabditis
elegans) 		PF00041
(fn3)
PF00069
(Pkinase)
PF07679
(I-set) 		4 GLY A 163
GLY A 165
VAL A 170
LYS A 185
 None
 0.41A 5izjA-3utoA:
25.6		 5izjA-3utoA:
22.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3

(Homo sapiens) 		PF00069
(Pkinase) 		4 GLY A  11
GLY A  13
VAL A  18
LYS A  33
 38R  A 350 ( 3.9A)
None
38R  A 350 ( 4.8A)
38R  A 350 (-2.9A)
 0.29A 5izjA-3zduA:
24.9		 5izjA-3zduA:
31.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4agu CYCLIN-DEPENDENT
KINASE-LIKE 1

(Homo sapiens) 		PF00069
(Pkinase) 		4 GLY A  11
GLY A  13
VAL A  18
LYS A  33
 D15  A 500 (-3.8A)
D15  A 500 (-3.6A)
D15  A 500 (-4.6A)
D15  A 500 ( 4.1A)
 0.30A 5izjA-4aguA:
26.4		 5izjA-4aguA:
24.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		5 GLY A  84
GLY A  86
VAL A  91
LYS A 106
LEU A 108
 None
None
None
EDO  A1419 (-3.3A)
EDO  A1419 (-4.2A)
 0.32A 5izjA-4aw2A:
32.9		 5izjA-4aw2A:
31.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bvu PROTEIN KINASE OSPG

(Shigella
flexneri) 		no annotation 4 GLY A  34
GLY A  36
SER A  37
LYS A  53
 None
 0.38A 5izjA-4bvuA:
8.3		 5izjA-4bvuA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c02 ACTIVIN RECEPTOR
TYPE-1

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		4 GLY A 215
GLY A 217
VAL A 222
LYS A 235
 None
None
TAK  A1507 (-4.7A)
TAK  A1507 ( 4.5A)
 0.34A 5izjA-4c02A:
16.8		 5izjA-4c02A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0t LIKELY PROTEIN
KINASE

(Candida
albicans) 		PF00069
(Pkinase) 		5 GLY A 247
GLY A 249
VAL A 254
LYS A 269
LEU A 271
 None
 0.35A 5izjA-4c0tA:
30.7		 5izjA-4c0tA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 GLY A 617
GLY A 619
VAL A 624
LYS A 655
 None
None
DI1  A1000 (-4.8A)
DI1  A1000 (-3.9A)
 0.31A 5izjA-4ckrA:
21.9		 5izjA-4ckrA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4czt CBL-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 23

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		4 GLY A  38
GLY A  40
VAL A  45
LYS A  60
 None
None
None
CPS  A1316 ( 4.8A)
 0.48A 5izjA-4cztA:
19.6		 5izjA-4cztA:
27.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e7w GLYCOGEN SYNTHASE
KINASE 3

(Ustilago maydis) 		PF00069
(Pkinase) 		4 GLY A  45
GLY A  47
VAL A  52
LYS A  66
 None
 0.35A 5izjA-4e7wA:
24.8		 5izjA-4e7wA:
27.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		4 GLY A  16
GLY A  18
VAL A  23
LYS A  38
 BX7  A 401 ( 3.7A)
BX7  A 401 (-3.5A)
BX7  A 401 (-4.4A)
BX7  A 401 ( 4.0A)
 0.38A 5izjA-4eutA:
12.7		 5izjA-4eutA:
26.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		4 GLY A  16
GLY A  18
VAL A  23
LYS A  38
 BX7  A 401 ( 3.8A)
BX7  A 401 (-3.7A)
BX7  A 401 ( 4.6A)
BX7  A 401 (-3.5A)
 0.32A 5izjA-4euuA:
18.7		 5izjA-4euuA:
26.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f99 CELL DIVISION CYCLE
7-RELATED PROTEIN
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		4 GLY A  65
GLY A  67
VAL A  72
LYS A  90
 ADP  A 601 ( 3.8A)
ADP  A 601 (-3.7A)
ADP  A 601 (-4.0A)
ADP  A 601 (-2.6A)
 0.35A 5izjA-4f99A:
22.1		 5izjA-4f99A:
26.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gv1 RAC-ALPHA
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		5 GLY A 157
GLY A 159
VAL A 164
LYS A 179
LEU A 181
 GOL  A 505 ( 3.4A)
0XZ  A 501 (-4.1A)
0XZ  A 501 (-4.5A)
GOL  A 503 ( 2.8A)
GOL  A 503 (-4.9A)
 0.39A 5izjA-4gv1A:
39.3		 5izjA-4gv1A:
38.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jrn RHOPTRY KINASE
FAMILY PROTEIN

(Toxoplasma
gondii) 		PF14531
(Kinase-like) 		4 GLY A 259
GLY A 261
VAL A 266
LYS A 281
 ANP  A 601 (-3.4A)
ANP  A 601 ( 3.3A)
ANP  A 601 (-4.1A)
ANP  A 601 (-3.2A)
 0.45A 5izjA-4jrnA:
19.3		 5izjA-4jrnA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 GLY A 479
GLY A 481
VAL A 486
LYS A 508
 ACP  A 801 (-3.4A)
ACP  A 801 (-3.6A)
ACP  A 801 (-4.2A)
ACP  A 801 (-2.7A)
 0.31A 5izjA-4k33A:
14.3		 5izjA-4k33A:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		4 GLY A 274
GLY A 276
VAL A 281
LYS A 295
 VGG  A 601 ( 3.8A)
None
VGG  A 601 ( 3.5A)
VGG  A 601 (-3.8A)
 0.46A 5izjA-4lggA:
20.4		 5izjA-4lggA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1

(Homo sapiens) 		PF00069
(Pkinase)
PF00169
(PH)
PF00615
(RGS) 		5 GLY A 198
GLY A 200
VAL A 205
LYS A 220
LEU A 222
 29X  A 702 ( 4.1A)
29X  A 702 (-3.6A)
29X  A 702 (-4.7A)
29X  A 702 (-3.6A)
None
 0.52A 5izjA-4mk0A:
36.2		 5izjA-4mk0A:
25.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4otd SERINE/THREONINE-PRO
TEIN KINASE N1

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		4 GLY A 628
GLY A 630
VAL A 635
LEU A 652
 None
 0.42A 5izjA-4otdA:
38.1		 5izjA-4otdA:
37.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p1e TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Escherichia
fergusonii) 		PF03480
(DctP) 		5 GLY A 139
SER A 138
PHE A  99
VAL A 243
LEU A  78
 IOD  A 404 ( 4.1A)
IOD  A 411 ( 3.1A)
None
None
None
 1.42A 5izjA-4p1eA:
undetectable		 5izjA-4p1eA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pwn SERINE/THREONINE-PRO
TEIN KINASE WNK1

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLY A 228
GLY A 230
SER A 231
VAL A 235
LEU A 252
 None
 0.41A 5izjA-4pwnA:
22.3		 5izjA-4pwnA:
25.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4q9z HUMAN PROTEIN KINASE
C THETA

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		5 GLY A 387
GLY A 389
SER A 390
LYS A 409
LEU A 411
 PZW  A 801 ( 3.8A)
None
None
None
None
 1.10A 5izjA-4q9zA:
28.5		 5izjA-4q9zA:
37.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4q9z HUMAN PROTEIN KINASE
C THETA

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		5 GLY A 387
GLY A 389
VAL A 394
LYS A 409
LEU A 411
 PZW  A 801 ( 3.8A)
None
PZW  A 801 (-4.6A)
None
None
 0.54A 5izjA-4q9zA:
28.5		 5izjA-4q9zA:
37.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qny MITOGEN ACTIVATED
PROTEIN KINASE,
PUTATIVE

(Leishmania
donovani) 		PF00069
(Pkinase) 		4 GLY A  28
GLY A  30
SER A  31
LYS A  51
 ANP  A 402 ( 3.7A)
ANP  A 402 (-3.4A)
None
ANP  A 402 (-2.8A)
 0.45A 5izjA-4qnyA:
26.3		 5izjA-4qnyA:
25.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ra4 PROTEIN KINASE C

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		5 GLY A 346
GLY A 348
SER A 349
VAL A 353
LEU A 370
 3KZ  A 701 (-3.3A)
None
None
3KZ  A 701 (-3.9A)
None
 0.71A 5izjA-4ra4A:
37.5		 5izjA-4ra4A:
36.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ra4 PROTEIN KINASE C

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		5 GLY A 346
SER A 349
VAL A 353
LYS A 368
LEU A 370
 3KZ  A 701 (-3.3A)
None
3KZ  A 701 (-3.9A)
3KZ  A 701 ( 4.7A)
None
 0.70A 5izjA-4ra4A:
37.5		 5izjA-4ra4A:
36.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		5 GLY A  25
PHE A  29
VAL A  32
LYS A  47
LEU A  49
 STU  A 601 (-3.5A)
None
STU  A 601 ( 4.8A)
STU  A 601 ( 3.7A)
None
 1.13A 5izjA-4rewA:
30.9		 5izjA-4rewA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		4 GLY A 193
VAL A 200
LYS A 215
LEU A 217
 SGV  A 601 (-3.4A)
SGV  A 601 ( 4.6A)
SGV  A 601 ( 4.2A)
None
 0.48A 5izjA-4tnbA:
30.1		 5izjA-4tnbA:
26.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase)
PF00226
(DnaJ) 		4 GLY A 105
GLY A 107
VAL A 112
LEU A 129
 ATP  A 501 (-3.5A)
ATP  A 501 (-3.2A)
ATP  A 501 (-4.0A)
None
 0.47A 5izjA-4wb7A:
47.7		 5izjA-4wb7A:
84.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase)
PF00226
(DnaJ) 		4 GLY A 105
VAL A 112
LYS A 127
LEU A 129
 ATP  A 501 (-3.5A)
ATP  A 501 (-4.0A)
ATP  A 501 (-2.6A)
None
 0.27A 5izjA-4wb7A:
47.7		 5izjA-4wb7A:
84.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wbo RHODOPSIN KINASE

(Bos taurus) 		PF00069
(Pkinase)
PF00615
(RGS) 		5 GLY A 194
GLY A 196
VAL A 201
LYS A 216
LEU A 218
 None
 0.54A 5izjA-4wboA:
27.9		 5izjA-4wboA:
27.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 GLY A 617
GLY A 619
VAL A 624
LYS A 644
 None
None
P30  A1001 ( 4.8A)
P30  A1001 ( 4.0A)
 0.48A 5izjA-4xufA:
13.2		 5izjA-4xufA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yff SERINE/THREONINE-PRO
TEIN KINASE TNNI3K

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 GLY A 470
GLY A 472
VAL A 477
LYS A 490
 4CV  A 801 ( 3.9A)
None
None
4CV  A 801 (-3.9A)
 0.36A 5izjA-4yffA:
22.0		 5izjA-4yffA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ylj DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 1A

(Homo sapiens) 		PF00069
(Pkinase) 		4 GLY A 166
GLY A 168
SER A 169
VAL A 173
 4E1  A 505 (-3.5A)
4E1  A 505 ( 4.9A)
None
4E1  A 505 (-4.5A)
 0.41A 5izjA-4yljA:
24.9		 5izjA-4yljA:
25.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		4 GLY A  63
GLY A  65
VAL A  70
LYS A  85
 5RC  A4000 ( 4.3A)
5RC  A4000 ( 3.9A)
5RC  A4000 (-4.6A)
5RC  A4000 (-2.8A)
 0.34A 5izjA-5es1A:
17.7		 5izjA-5es1A:
32.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fd2 SERINE/THREONINE-PRO
TEIN KINASE B-RAF

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 GLY A 464
GLY A 466
VAL A 471
LYS A 483
 None
None
5XJ  A 801 (-4.6A)
5XJ  A 801 (-3.8A)
 0.27A 5izjA-5fd2A:
7.3		 5izjA-5fd2A:
25.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 GLY A 731
GLY A 733
VAL A 738
LYS A 758
 PP1  A2012 ( 3.9A)
None
PP1  A2012 (-4.4A)
PP1  A2012 (-4.1A)
 0.47A 5izjA-5fm2A:
24.1		 5izjA-5fm2A:
26.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5idn CYCLIN-DEPENDENT
KINASE 8

(Homo sapiens) 		PF00069
(Pkinase) 		4 GLY A  28
GLY A  30
VAL A  35
LYS A  52
 6A7  A 401 (-3.6A)
None
6A7  A 401 ( 4.5A)
6A7  A 401 ( 2.9A)
 0.48A 5izjA-5idnA:
14.9		 5izjA-5idnA:
25.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ig1 CAMK/CAMK2 PROTEIN
KINASE

(Salpingoeca
rosetta) 		PF00069
(Pkinase) 		4 GLY A  25
GLY A  27
VAL A  32
LYS A  47
 None
 0.33A 5izjA-5ig1A:
22.1		 5izjA-5ig1A:
28.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 GLY A 719
GLY A 721
VAL A 726
LYS A 745
 6HJ  A1101 ( 4.2A)
None
6HJ  A1101 ( 4.7A)
6HJ  A1101 (-4.2A)
 0.48A 5izjA-5j9zA:
22.8		 5izjA-5j9zA:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		4 GLY A 890
VAL A 897
LYS A 911
LEU A 913
 ATP  A1200 ( 4.6A)
ATP  A1200 ( 4.5A)
ATP  A1200 (-3.8A)
None
 0.38A 5izjA-5lpyA:
21.1		 5izjA-5lpyA:
26.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lxd DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLY A 156
GLY A 158
SER A 159
VAL A 163
LYS A 178
 7A7  A 501 (-3.2A)
None
None
7A7  A 501 (-4.4A)
7A7  A 501 (-3.5A)
 0.68A 5izjA-5lxdA:
24.8		 5izjA-5lxdA:
26.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ncl SERINE/THREONINE-PRO
TEIN KINASE CBK1

(Saccharomyces
cerevisiae) 		no annotation 5 GLY A 359
GLY A 361
VAL A 366
LYS A 381
LEU A 383
 ANP  A 801 ( 4.1A)
ANP  A 801 (-3.1A)
ANP  A 801 (-4.7A)
ANP  A 801 (-2.6A)
None
 0.53A 5izjA-5nclA:
28.1		 5izjA-5nclA:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o2c SERINE/THREONINE-PRO
TEIN KINASE WNK3

(Homo sapiens) 		PF00069
(Pkinase)
PF12202
(OSR1_C) 		4 GLY A 154
GLY A 156
VAL A 161
LEU A 178
 None
 0.45A 5izjA-5o2cA:
21.8		 5izjA-5o2cA:
26.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tur SERINE/THREONINE-PRO
TEIN KINASE PIM-1

(Homo sapiens) 		no annotation 4 GLY A  45
GLY A  47
VAL A  52
LYS A  67
 None
None
7LK  A 401 (-4.9A)
None
 0.46A 5izjA-5turA:
28.0		 5izjA-5turA:
23.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5u7q RHO-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLY A  99
GLY A 101
VAL A 106
LYS A 121
LEU A 123
 None
 0.41A 5izjA-5u7qA:
34.6		 5izjA-5u7qA:
34.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB

(Mycobacterium
tuberculosis) 		no annotation 4 GLY A  18
GLY A  20
VAL A  25
LYS A  40
 G93  A 301 ( 3.2A)
None
G93  A 301 (-3.4A)
G93  A 301 (-3.0A)
 0.22A 5izjA-5u94A:
27.5		 5izjA-5u94A:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uuu BETA-ADRENERGIC
RECEPTOR KINASE 1

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		5 GLY A 198
GLY A 200
VAL A 205
LYS A 220
LEU A 222
 QRW  A 601 ( 4.5A)
QRW  A 601 (-3.6A)
QRW  A 601 (-4.7A)
QRW  A 601 (-3.0A)
QRW  A 601 (-4.3A)
 0.63A 5izjA-5uuuA:
29.8		 5izjA-5uuuA:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLY A 117
GLY A 119
SER A 120
VAL A 124
LYS A 139
 H8H  A 401 ( 3.7A)
None
None
H8H  A 401 (-4.7A)
H8H  A 401 (-4.9A)
 0.80A 5izjA-5vcxA:
24.3		 5izjA-5vcxA:
26.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xvu CASEIN KINASE 2,
ALPHA SUBUNIT

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		5 GLY A  50
GLY A  52
VAL A  57
LYS A  72
LEU A  74
 ATP  A 403 (-3.4A)
ATP  A 403 ( 3.9A)
ATP  A 403 (-3.9A)
ATP  A 403 (-3.2A)
None
 0.74A 5izjA-5xvuA:
24.7		 5izjA-5xvuA:
26.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y86 DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 3

(Homo sapiens) 		no annotation 5 GLY A 216
GLY A 218
SER A 219
VAL A 223
LYS A 238
 None
PO4  A 602 (-3.5A)
PO4  A 602 (-2.7A)
HRM  A 601 ( 4.9A)
HRM  A 601 (-3.3A)
 0.65A 5izjA-5y86A:
24.1		 5izjA-5y86A:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b4w DUAL SPECIFICITY
PROTEIN KINASE TTK

(Homo sapiens) 		no annotation 4 GLY A 532
GLY A 534
VAL A 539
LYS A 553
 CQ7  A 801 ( 4.0A)
None
CQ7  A 801 ( 4.8A)
CQ7  A 801 (-3.2A)
 0.39A 5izjA-6b4wA:
24.1		 5izjA-6b4wA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bfn INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 1

(Homo sapiens) 		no annotation 5 GLY A 219
GLY A 221
VAL A 226
LYS A 239
LEU A 241
 DL1  A 601 ( 4.1A)
None
None
DL1  A 601 ( 4.1A)
None
 0.69A 5izjA-6bfnA:
20.4		 5izjA-6bfnA:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bql CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 2

(Homo sapiens) 		no annotation 6 GLY A 172
GLY A 174
SER A 175
VAL A 179
LYS A 194
LEU A 196
 BI9  A 501 (-3.6A)
None
ACT  A 504 (-3.3A)
BI9  A 501 ( 4.8A)
NH4  A 506 ( 4.4A)
None
 0.60A 5izjA-6bqlA:
29.2		 5izjA-6bqlA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c0t CGMP-DEPENDENT
PROTEIN KINASE 1

(Homo sapiens) 		no annotation 6 GLY A 367
GLY A 369
PHE A 371
VAL A 374
LYS A 390
LEU A 392
 EE4  A 701 (-3.9A)
EE4  A 701 (-3.4A)
EE4  A 701 (-3.0A)
EE4  A 701 (-4.4A)
DMS  A 702 (-3.5A)
EE4  A 701 ( 4.6A)
 0.51A 5izjA-6c0tA:
31.6		 5izjA-6c0tA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo sapiens) 		no annotation 5 GLY A  67
GLY A  69
PHE A  71
VAL A  74
LYS A  89
 None
 0.71A 5izjA-6c9dA:
29.1		 5izjA-6c9dA:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ccf CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 1

(Homo sapiens) 		no annotation 5 GLY A 135
GLY A 137
VAL A 142
LYS A 157
LEU A 159
 H1N  A 501 ( 3.8A)
None
H1N  A 501 (-4.4A)
H1N  A 501 (-2.8A)
None
 0.44A 5izjA-6ccfA:
28.2		 5izjA-6ccfA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyl DUAL SPECIFICITY
PROTEIN KINASE CLK2

(Homo sapiens) 		no annotation 4 GLY A 170
GLY A 172
VAL A 177
LYS A 193
 3NG  A 501 (-3.5A)
3NG  A 501 ( 4.5A)
3NG  A 501 ( 4.4A)
3NG  A 501 (-3.0A)
 0.46A 5izjA-6fylA:
25.1		 5izjA-6fylA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4

(Homo sapiens) 		no annotation 4 GLY A 168
GLY A 170
VAL A 175
LYS A 191
 3NG  A 501 (-3.5A)
3NG  A 501 ( 4.9A)
3NG  A 501 ( 4.3A)
3NG  A 501 (-2.7A)
 0.34A 5izjA-6fyvA:
25.6		 5izjA-6fyvA:
undetectable