SIMILAR PATTERNS OF AMINO ACIDS FOR 5IZJ_F_AZ1F2_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)

Filter list by:

	Hit	Macromolecule/ Organism	Pfam	Res.	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1dqw	OROTIDINE 5'-PHOSPHATE DECARBOXYLASE (Saccharomyces cerevisiae)	PF00215 (OMPdecase)	5	GLY A 203 GLY A 214 GLY A 234 VAL A 204 LEU A 237	None	1.37A	5izjB-1dqwA: undetectable	5izjB-1dqwA: 23.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1fot	CAMP-DEPENDENT PROTEIN KINASE TYPE 1 (Saccharomyces cerevisiae)	PF00069 (Pkinase)	5	GLY A 94 GLY A 96 SER A 97 GLY A 99 LEU A 118	None	0.83A	5izjB-1fotA: 39.6	5izjB-1fotA: 45.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1gng	GLYCOGEN SYNTHASE KINASE-3 BETA (Homo sapiens)	PF00069 (Pkinase)	5	GLY A 63 GLY A 65 SER A 66 GLY A 68 VAL A 70	None	0.64A	5izjB-1gngA: 24.9	5izjB-1gngA: 23.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1gzk	RAC-BETA SERINE/THREONINE PROTEIN KINASE (Homo sapiens)	PF00069 (Pkinase) PF00433 (Pkinase_C)	5	GLY A 159 GLY A 161 GLY A 164 VAL A 166 LEU A 183	None	0.32A	5izjB-1gzkA: 29.8	5izjB-1gzkA: 39.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1kob	TWITCHIN (Aplysia californica)	PF00069 (Pkinase)	4	GLY A 60 GLY A 62 GLY A 65 VAL A 67	None	0.26A	5izjB-1kobA: 25.4	5izjB-1kobA: 26.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1q18	GLUCOKINASE (Escherichia coli)	PF02685 (Glucokinase)	5	GLY A 242 PHE A 244 GLY A 245 VAL A 296 LEU A 248	None	1.34A	5izjB-1q18A: undetectable	5izjB-1q18A: 22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1rjb	FL CYTOKINE RECEPTOR (Homo sapiens)	PF07714 (Pkinase_Tyr)	4	GLY A 617 GLY A 619 GLY A 622 VAL A 624	None	0.30A	5izjB-1rjbA: 20.8	5izjB-1rjbA: 24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1t46	HOMO SAPIENS V-KIT HARDY-ZUCKERMAN 4 FELINE SARCOMA VIRAL ONCOGENE HOMOLOG (Homo sapiens)	PF07714 (Pkinase_Tyr)	4	GLY A 596 GLY A 598 GLY A 601 VAL A 603	None None None STI A 3 ( 4.6A)	0.34A	5izjB-1t46A: 15.7	5izjB-1t46A: 24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1tki	TITIN (Homo sapiens)	PF00069 (Pkinase)	4	GLY A 31 GLY A 33 GLY A 36 VAL A 38	None	0.37A	5izjB-1tkiA: 25.4	5izjB-1tkiA: 25.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1u59	TYROSINE-PROTEIN KINASE ZAP-70 (Homo sapiens)	PF07714 (Pkinase_Tyr)	4	GLY A 345 GLY A 347 GLY A 350 VAL A 352	STU A 100 (-3.3A) None None STU A 100 (-4.8A)	0.27A	5izjB-1u59A: 24.0	5izjB-1u59A: 22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1u5q	SERINE/THREONINE PROTEIN KINASE TAO2 (Rattus norvegicus)	PF00069 (Pkinase)	5	GLY A 35 GLY A 37 SER A 38 GLY A 40 VAL A 42	None	0.64A	5izjB-1u5qA: 27.7	5izjB-1u5qA: 25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1v9t	CYCLOPHILIN B (Escherichia coli)	PF00160 (Pro_isomerase)	5	GLY A 86 PHE A 125 GLY A 126 VAL A 128 LEU A 20	None	0.82A	5izjB-1v9tA: undetectable	5izjB-1v9tA: 18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1zy4	SERINE/THREONINE-PRO TEIN KINASE GCN2 (Saccharomyces cerevisiae)	PF00069 (Pkinase)	4	GLY A 606 GLY A 608 GLY A 611 VAL A 613	None	0.17A	5izjB-1zy4A: 21.0	5izjB-1zy4A: 25.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2c7z	3-KETOACYL-COA THIOLASE 2 (Arabidopsis thaliana)	PF00108 (Thiolase_N) PF02803 (Thiolase_C)	4	GLY A 162 GLY A 164 GLY A 299 VAL A 301	None	0.34A	5izjB-2c7zA: undetectable	5izjB-2c7zA: 22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2cw5	BACTERIAL FLUORINATING ENZYME HOMOLOG (Thermus thermophilus)	PF01887 (SAM_adeno_trans)	5	GLY A 238 GLY A 185 PHE A 181 VAL A 235 LEU A 246	None	1.46A	5izjB-2cw5A: undetectable	5izjB-2cw5A: 20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2eu9	DUAL SPECIFICITY PROTEIN KINASE CLK3 (Homo sapiens)	PF00069 (Pkinase)	4	GLY A 163 GLY A 165 GLY A 168 VAL A 170	None	0.30A	5izjB-2eu9A: 25.6	5izjB-2eu9A: 23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2g04	PROBABLE FATTY-ACID-COA RACEMASE FAR (Mycobacterium tuberculosis)	PF02515 (CoA_transf_3)	5	GLY A 193 GLY A 162 PHE A 159 GLY A 160 VAL A 194	None	0.98A	5izjB-2g04A: undetectable	5izjB-2g04A: 22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2g04	PROBABLE FATTY-ACID-COA RACEMASE FAR (Mycobacterium tuberculosis)	PF02515 (CoA_transf_3)	5	GLY A 193 GLY A 162 SER A 163 GLY A 160 VAL A 194	None	1.13A	5izjB-2g04A: undetectable	5izjB-2g04A: 22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2gcd	SERINE/THREONINE-PRO TEIN KINASE TAO2 (Rattus norvegicus)	PF00069 (Pkinase)	5	GLY A 35 GLY A 37 SER A 38 GLY A 40 VAL A 42	STU A 400 (-3.3A) None None None STU A 400 ( 4.8A)	0.69A	5izjB-2gcdA: 27.7	5izjB-2gcdA: 26.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2h8h	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC (Homo sapiens)	PF00017 (SH2) PF00018 (SH3_1) PF07714 (Pkinase_Tyr)	5	GLY A 274 GLY A 276 GLY A 279 VAL A 281 LEU A 297	H8H A 534 ( 3.8A) None None H8H A 534 (-4.4A) None	0.43A	5izjB-2h8hA: 21.4	5izjB-2h8hA: 22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2hk5	TYROSINE-PROTEIN KINASE HCK (Homo sapiens)	PF07714 (Pkinase_Tyr)	4	GLY A 252 GLY A 254 GLY A 257 VAL A 259	None None None 1BM A 499 ( 4.8A)	0.24A	5izjB-2hk5A: 17.5	5izjB-2hk5A: 23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2hnh	DNA POLYMERASE III ALPHA SUBUNIT (Escherichia coli)	PF02811 (PHP) PF07733 (DNA_pol3_alpha) PF14579 (HHH_6)	5	GLY A 140 GLY A 134 GLY A 133 VAL A 139 LEU A 84	None PO4 A 911 ( 4.1A) None None None	1.34A	5izjB-2hnhA: undetectable	5izjB-2hnhA: 17.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2i0e	PROTEIN KINASE C-BETA II (Homo sapiens)	PF00069 (Pkinase) PF00433 (Pkinase_C)	5	GLY A 349 GLY A 351 SER A 352 GLY A 354 LEU A 373	PDS A 901 ( 3.7A) None None None None	1.32A	5izjB-2i0eA: 37.2	5izjB-2i0eA: 36.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2jam	CALCIUM/CALMODULIN-D EPENDENT PROTEIN KINASE TYPE 1G (Homo sapiens)	PF00069 (Pkinase)	4	GLY A 30 GLY A 32 PHE A 34 VAL A 37	None None None J60 A1305 (-4.8A)	0.26A	5izjB-2jamA: 20.1	5izjB-2jamA: 30.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2og8	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE LCK (Homo sapiens)	PF07714 (Pkinase_Tyr)	4	GLY A 252 GLY A 254 GLY A 257 VAL A 259	None	0.25A	5izjB-2og8A: 22.2	5izjB-2og8A: 23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ogv	MACROPHAGE COLONY-STIMULATING FACTOR 1 RECEPTOR PRECURSOR (Homo sapiens)	PF07714 (Pkinase_Tyr)	4	GLY A 589 GLY A 591 GLY A 594 VAL A 596	None	0.22A	5izjB-2ogvA: 21.1	5izjB-2ogvA: 25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2r4b	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4 (Homo sapiens)	PF07714 (Pkinase_Tyr)	5	GLY A 725 GLY A 727 GLY A 730 VAL A 732 LEU A 753	None None None GW7 A 1 ( 4.8A) None	0.85A	5izjB-2r4bA: 11.1	5izjB-2r4bA: 24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2wtk	SERINE/THREONINE-PRO TEIN KINASE 11 (Homo sapiens)	PF00069 (Pkinase)	5	GLY C 56 GLY C 58 SER C 59 GLY C 61 VAL C 63	ANP C 2 (-3.3A) ANP C 2 (-3.0A) None ANP C 2 (-3.8A) ANP C 2 (-4.2A)	0.69A	5izjB-2wtkC: 29.8	5izjB-2wtkC: 28.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2xk9	CHECKPOINT KINASE 2 (Homo sapiens)	PF00069 (Pkinase)	4	GLY A 227 GLY A 229 GLY A 232 VAL A 234	XK9 A1511 ( 4.5A) None None XK9 A1511 (-4.8A)	0.37A	5izjB-2xk9A: 23.6	5izjB-2xk9A: 34.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2xyu	EPHRIN TYPE-A RECEPTOR 4, (Mus musculus)	PF07714 (Pkinase_Tyr)	4	GLY A 628 GLY A 630 GLY A 633 VAL A 635	None None None Q9G A1898 ( 4.7A)	0.33A	5izjB-2xyuA: 17.5	5izjB-2xyuA: 24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2z8c	INSULIN RECEPTOR (Homo sapiens)	PF07714 (Pkinase_Tyr)	5	GLY A1003 GLY A1005 SER A1006 PHE A1007 GLY A1008	S91 A 1 ( 3.9A) None None None None	0.79A	5izjB-2z8cA: 24.6	5izjB-2z8cA: 23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2zv7	TYROSINE-PROTEIN KINASE LYN (Mus musculus)	PF07714 (Pkinase_Tyr)	4	GLY A 254 GLY A 256 GLY A 259 VAL A 261	None	0.34A	5izjB-2zv7A: 24.1	5izjB-2zv7A: 23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3cea	MYO-INOSITOL 2-DEHYDROGENASE (Lactobacillus plantarum)	PF01408 (GFO_IDH_MocA) PF02894 (GFO_IDH_MocA_C)	4	GLY A 257 SER A 258 GLY A 260 VAL A 262	None	0.36A	5izjB-3ceaA: undetectable	5izjB-3ceaA: 21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3coi	MITOGEN-ACTIVATED PROTEIN KINASE 13 (Homo sapiens)	PF00069 (Pkinase)	5	GLY A 32 GLY A 34 GLY A 37 VAL A 39 LEU A 56	None	0.81A	5izjB-3coiA: 22.6	5izjB-3coiA: 27.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3dm0	MALTOSE-BINDING PERIPLASMIC PROTEIN FUSED WITH RACK1 (Arabidopsis thaliana; Escherichia coli)	PF00400 (WD40) PF01547 (SBP_bac_1)	5	GLY A1213 SER A1198 GLY A1212 VAL A1217 LEU A1241	None	1.44A	5izjB-3dm0A: undetectable	5izjB-3dm0A: 19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3f3z	CALCIUM/CALMODULIN-D EPENDENT PROTEIN KINASE WITH A KINASE DOMAIN AND 4 CALMODULIN LIKE EF HANDS (Cryptosporidium parvum)	PF00069 (Pkinase)	5	GLY A 35 GLY A 37 SER A 38 GLY A 40 VAL A 42	DRK A 1 ( 3.9A) None None None DRK A 1 ( 4.9A)	0.76A	5izjB-3f3zA: 30.0	5izjB-3f3zA: 28.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3fhh	OUTER MEMBRANE HEME RECEPTOR SHUA (Shigella dysenteriae)	PF00593 (TonB_dep_Rec) PF07715 (Plug)	4	GLY A 143 GLY A 145 VAL A 636 LEU A 609	None	0.36A	5izjB-3fhhA: undetectable	5izjB-3fhhA: 19.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3hdn	SERINE/THREONINE-PRO TEIN KINASE SGK1 (Homo sapiens)	PF00069 (Pkinase)	5	GLY A 105 GLY A 107 SER A 108 GLY A 110 LEU A 129	None GMG A 1 (-3.3A) None None None	1.16A	5izjB-3hdnA: 28.5	5izjB-3hdnA: 38.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3hng	VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 1 (Homo sapiens)	PF07714 (Pkinase_Tyr)	4	GLY A 834 GLY A 836 GLY A 839 VAL A 841	None None None 8ST A2001 ( 4.6A)	0.28A	5izjB-3hngA: 22.2	5izjB-3hngA: 23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3igo	CALMODULIN-DOMAIN PROTEIN KINASE 1 (Cryptosporidium parvum)	PF00069 (Pkinase) PF13499 (EF-hand_7)	4	GLY A 83 GLY A 85 SER A 86 GLY A 88	ANP A 610 (-3.5A) ANP A 610 (-2.9A) ANP A 610 (-2.6A) ANP A 610 (-4.5A)	0.28A	5izjB-3igoA: 23.3	5izjB-3igoA: 25.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3is5	CALCIUM-DEPENDENT PROTEIN KINASE (Toxoplasma gondii)	PF00069 (Pkinase)	5	GLY A 142 GLY A 144 PHE A 146 GLY A 147 VAL A 149	ANP A 1 (-3.5A) ANP A 1 (-3.4A) None None ANP A 1 (-4.9A)	0.81A	5izjB-3is5A: 19.5	5izjB-3is5A: 25.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3kex	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-3 (Homo sapiens)	PF07714 (Pkinase_Tyr)	5	GLY A 697 GLY A 699 PHE A 701 GLY A 702 VAL A 704	ANP A 1 (-3.7A) ANP A 1 (-2.8A) None None ANP A 1 (-3.9A)	0.56A	5izjB-3kexA: 19.4	5izjB-3kexA: 25.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3l9y	SUPEROXIDE DISMUTASE [CU-ZN] (Bombyx mori)	PF00080 (Sod_Cu)	5	GLY A 32 GLY A 15 SER A 14 VAL A 97 LEU A 37	None	1.36A	5izjB-3l9yA: undetectable	5izjB-3l9yA: 18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3lzb	EPIDERMAL GROWTH FACTOR RECEPTOR (Homo sapiens)	PF07714 (Pkinase_Tyr)	5	GLY A 695 GLY A 697 GLY A 700 VAL A 702 LEU A 723	ITI A 1 ( 4.8A) None None ITI A 1 (-4.8A) None	0.76A	5izjB-3lzbA: 20.1	5izjB-3lzbA: 22.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3mvj	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA (Homo sapiens)	PF00069 (Pkinase)	5	GLY A 50 GLY A 52 GLY A 55 VAL A 57 LEU A 74	XFE A 351 ( 4.0A) None None XFE A 351 ( 4.5A) None	0.45A	5izjB-3mvjA: 46.1	5izjB-3mvjA: 94.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3mvj	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA (Homo sapiens)	PF00069 (Pkinase)	5	GLY A 50 GLY A 52 SER A 53 GLY A 55 VAL A 57	XFE A 351 ( 4.0A) None None None XFE A 351 ( 4.5A)	0.54A	5izjB-3mvjA: 46.1	5izjB-3mvjA: 94.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3mvj	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA (Homo sapiens)	PF00069 (Pkinase)	5	GLY A 50 GLY A 52 SER A 53 PHE A 54 GLY A 55	XFE A 351 ( 4.0A) None None None None	1.00A	5izjB-3mvjA: 46.1	5izjB-3mvjA: 94.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3my0	SERINE/THREONINE-PRO TEIN KINASE RECEPTOR R3 (Homo sapiens)	PF07714 (Pkinase_Tyr)	4	GLY A 209 GLY A 211 GLY A 214 VAL A 216	None None None LDN A 600 (-4.5A)	0.33A	5izjB-3my0A: 21.1	5izjB-3my0A: 21.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3o96	RAC-ALPHA SERINE/THREONINE-PRO TEIN KINASE (Homo sapiens)	PF00069 (Pkinase) PF00169 (PH)	5	GLY A 157 GLY A 159 GLY A 162 VAL A 164 LEU A 181	GLY A 157 ( 0.0A) GLY A 159 ( 0.0A) GLY A 162 ( 0.0A) VAL A 164 ( 0.6A) LEU A 181 ( 0.6A)	0.19A	5izjB-3o96A: 30.4	5izjB-3o96A: 34.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ppz	SERINE/THREONINE-PRO TEIN KINASE CTR1 (Arabidopsis thaliana)	PF07714 (Pkinase_Tyr)	6	GLY A 558 GLY A 560 SER A 561 GLY A 563 VAL A 565 LEU A 580	STU A 1 (-3.2A) None None None STU A 1 (-4.9A) None	0.65A	5izjB-3ppzA: 26.1	5izjB-3ppzA: 26.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3qfv	CDC42BPB PROTEIN (Homo sapiens)	PF00069 (Pkinase)	4	GLY A 83 GLY A 88 VAL A 90 LEU A 107	NM7 A 416 (-3.0A) None NM7 A 416 (-3.7A) EDO A 417 (-4.6A)	0.33A	5izjB-3qfvA: 30.8	5izjB-3qfvA: 33.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3sv0	CASEIN KINASE I-LIKE (Oryza sativa)	PF00069 (Pkinase)	4	GLY A 16 GLY A 18 SER A 19 GLY A 21	None	0.37A	5izjB-3sv0A: 18.8	5izjB-3sv0A: 22.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3txo	PROTEIN KINASE C ETA TYPE (Homo sapiens)	PF00069 (Pkinase) PF00433 (Pkinase_C)	6	GLY A 362 GLY A 364 SER A 365 GLY A 367 VAL A 369 LEU A 386	07U A 1 ( 4.2A) None None None 07U A 1 (-4.8A) None	0.80A	5izjB-3txoA: 31.6	5izjB-3txoA: 39.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3upg	OUTER MEMBRANE PROTEIN C (Salmonella enterica)	PF00267 (Porin_1)	5	GLY A 52 GLY A 54 PHE A 40 GLY A 42 LEU A 11	None	0.94A	5izjB-3upgA: undetectable	5izjB-3upgA: 20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3uto	TWITCHIN (Caenorhabditis elegans)	PF00041 (fn3) PF00069 (Pkinase) PF07679 (I-set)	4	GLY A 163 GLY A 165 GLY A 168 VAL A 170	None	0.26A	5izjB-3utoA: 25.7	5izjB-3utoA: 22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3vid	VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2 (Homo sapiens)	PF07714 (Pkinase_Tyr)	4	GLY A 841 GLY A 843 GLY A 846 VAL A 848	4TT A2001 ( 4.8A) None None 4TT A2001 ( 4.5A)	0.22A	5izjB-3vidA: 21.1	5izjB-3vidA: 22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3vte	TETRAHYDROCANNABINOL IC ACID SYNTHASE (Cannabis sativa)	PF01565 (FAD_binding_4) PF08031 (BBE)	5	GLY A 183 GLY A 187 PHE A 433 GLY A 188 LEU A 199	FAD A 607 (-3.1A) None None None None	1.27A	5izjB-3vteA: undetectable	5izjB-3vteA: 19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3wz2	UNCHARACTERIZED PROTEIN (Pyrococcus furiosus)	PF09754 (PAC2)	5	GLY A 132 SER A 133 GLY A 131 VAL A 173 LEU A 140	None	1.17A	5izjB-3wz2A: undetectable	5izjB-3wz2A: 22.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3zdu	CYCLIN-DEPENDENT KINASE-LIKE 3 (Homo sapiens)	PF00069 (Pkinase)	4	GLY A 11 GLY A 13 GLY A 16 VAL A 18	38R A 350 ( 3.9A) None None 38R A 350 ( 4.8A)	0.33A	5izjB-3zduA: 24.4	5izjB-3zduA: 31.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4agd	VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2 (Homo sapiens)	PF07714 (Pkinase_Tyr)	4	GLY A 841 GLY A 843 GLY A 846 VAL A 848	B49 A2000 ( 4.6A) None None None	0.29A	5izjB-4agdA: 21.0	5izjB-4agdA: 23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4agu	CYCLIN-DEPENDENT KINASE-LIKE 1 (Homo sapiens)	PF00069 (Pkinase)	4	GLY A 11 GLY A 13 GLY A 16 VAL A 18	D15 A 500 (-3.8A) D15 A 500 (-3.6A) D15 A 500 (-3.7A) D15 A 500 (-4.6A)	0.29A	5izjB-4aguA: 25.9	5izjB-4aguA: 24.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4aw2	SERINE/THREONINE-PRO TEIN KINASE MRCK ALPHA (Rattus norvegicus)	PF00069 (Pkinase) PF00433 (Pkinase_C)	5	GLY A 84 GLY A 86 GLY A 89 VAL A 91 LEU A 108	None None None None EDO A1419 (-4.2A)	0.30A	5izjB-4aw2A: 31.7	5izjB-4aw2A: 31.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4c02	ACTIVIN RECEPTOR TYPE-1 (Homo sapiens)	PF00069 (Pkinase) PF08515 (TGF_beta_GS)	4	GLY A 215 GLY A 217 GLY A 220 VAL A 222	None None None TAK A1507 (-4.7A)	0.29A	5izjB-4c02A: 21.8	5izjB-4c02A: 21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4c0t	LIKELY PROTEIN KINASE (Candida albicans)	PF00069 (Pkinase)	4	GLY A 247 GLY A 249 VAL A 254 LEU A 271	None	0.30A	5izjB-4c0tA: 30.2	5izjB-4c0tA: 18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4d65	PORIN 2 (Providencia stuartii)	PF00267 (Porin_1)	5	GLY A 53 GLY A 55 PHE A 41 GLY A 43 LEU A 11	None	0.86A	5izjB-4d65A: undetectable	5izjB-4d65A: 20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4e7w	GLYCOGEN SYNTHASE KINASE 3 (Ustilago maydis)	PF00069 (Pkinase)	5	GLY A 45 GLY A 47 SER A 48 GLY A 50 VAL A 52	None	1.09A	5izjB-4e7wA: 24.8	5izjB-4e7wA: 27.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4f0i	HIGH AFFINITY NERVE GROWTH FACTOR RECEPTOR (Homo sapiens)	PF07714 (Pkinase_Tyr)	4	GLY A 516 GLY A 518 GLY A 521 VAL A 523	None	0.25A	5izjB-4f0iA: 15.0	5izjB-4f0iA: 23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4fr4	SERINE/THREONINE-PRO TEIN KINASE 32A (Homo sapiens)	PF00069 (Pkinase)	5	GLY A 30 GLY A 32 SER A 33 GLY A 35 VAL A 37	STU A 401 (-3.3A) None None None STU A 401 ( 4.9A)	0.60A	5izjB-4fr4A: 32.3	5izjB-4fr4A: 29.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4g34	EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE 3 (Homo sapiens)	PF00069 (Pkinase)	4	GLY A 599 GLY A 601 GLY A 604 VAL A 606	None None None 924 A1101 ( 4.8A)	0.34A	5izjB-4g34A: 21.7	5izjB-4g34A: 24.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4gv1	RAC-ALPHA SERINE/THREONINE-PRO TEIN KINASE (Homo sapiens)	PF00069 (Pkinase) PF00433 (Pkinase_C)	5	GLY A 157 GLY A 159 GLY A 162 VAL A 164 LEU A 181	GOL A 505 ( 3.4A) 0XZ A 501 (-4.1A) 0XZ A 501 (-3.8A) 0XZ A 501 (-4.5A) GOL A 503 (-4.9A)	0.29A	5izjB-4gv1A: 37.5	5izjB-4gv1A: 38.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4hvi	TYROSINE-PROTEIN KINASE JAK3 (Homo sapiens)	PF07714 (Pkinase_Tyr)	4	GLY A 829 GLY A 831 GLY A 834 VAL A 836	19S A1201 (-3.7A) 19S A1201 ( 4.3A) 19S A1201 ( 4.9A) 19S A1201 (-4.4A)	0.27A	5izjB-4hviA: 23.6	5izjB-4hviA: 24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4idt	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 14 (Homo sapiens)	PF00069 (Pkinase)	4	GLY A 407 GLY A 409 SER A 410 GLY A 412	T28 A 701 ( 3.6A) T28 A 701 ( 3.0A) None None	0.31A	5izjB-4idtA: 23.6	5izjB-4idtA: 24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4k11	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC (Homo sapiens)	PF00017 (SH2) PF00018 (SH3_1) PF07714 (Pkinase_Tyr)	5	GLY A 274 GLY A 276 GLY A 279 VAL A 281 LEU A 297	0J9 A 601 ( 4.0A) None None 0J9 A 601 (-4.4A) None	0.57A	5izjB-4k11A: 20.9	5izjB-4k11A: 22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4k33	FIBROBLAST GROWTH FACTOR RECEPTOR 3 (Homo sapiens)	PF07714 (Pkinase_Tyr)	4	GLY A 479 GLY A 481 GLY A 484 VAL A 486	ACP A 801 (-3.4A) ACP A 801 (-3.6A) ACP A 801 (-3.6A) ACP A 801 (-4.2A)	0.34A	5izjB-4k33A: 18.8	5izjB-4k33A: 25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ks8	SERINE/THREONINE-PRO TEIN KINASE PAK 6 (Homo sapiens)	PF00069 (Pkinase)	5	GLY A 414 GLY A 416 SER A 417 GLY A 419 VAL A 421	B49 A 701 ( 4.3A) None None None None	0.71A	5izjB-4ks8A: 28.1	5izjB-4ks8A: 27.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4l9o	SEC16,PROTEIN TRANSPORT PROTEIN SEC13 (Komagataella pastoris; Komagataella phaffii)	PF00400 (WD40)	4	GLY A1077 SER A1078 GLY A1085 VAL A2013	None	0.32A	5izjB-4l9oA: undetectable	5izjB-4l9oA: 21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4lgg	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC (Gallus gallus)	PF07714 (Pkinase_Tyr)	4	GLY A 274 GLY A 276 GLY A 279 VAL A 281	VGG A 601 ( 3.8A) None None VGG A 601 ( 3.5A)	0.26A	5izjB-4lggA: 20.1	5izjB-4lggA: 23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4mk0	BETA-ADRENERGIC RECEPTOR KINASE 1 (Homo sapiens)	PF00069 (Pkinase) PF00169 (PH) PF00615 (RGS)	5	GLY A 198 GLY A 200 GLY A 203 VAL A 205 LEU A 222	29X A 702 ( 4.1A) 29X A 702 (-3.6A) 29X A 702 (-3.5A) 29X A 702 (-4.7A) None	0.40A	5izjB-4mk0A: 26.8	5izjB-4mk0A: 25.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4otd	SERINE/THREONINE-PRO TEIN KINASE N1 (Homo sapiens)	PF00069 (Pkinase) PF00433 (Pkinase_C)	5	GLY A 628 GLY A 630 GLY A 633 VAL A 635 LEU A 652	None	0.78A	5izjB-4otdA: 36.5	5izjB-4otdA: 37.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4p1e	TRAP DICARBOXYLATE TRANSPORTER, DCTP SUBUNIT (Escherichia fergusonii)	PF03480 (DctP)	5	GLY A 139 SER A 138 PHE A 99 VAL A 243 LEU A 78	IOD A 404 ( 4.1A) IOD A 411 ( 3.1A) None None None	1.41A	5izjB-4p1eA: undetectable	5izjB-4p1eA: 21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4pwn	SERINE/THREONINE-PRO TEIN KINASE WNK1 (Homo sapiens)	PF00069 (Pkinase)	5	GLY A 228 GLY A 230 SER A 231 PHE A 232 LEU A 252	None	0.79A	5izjB-4pwnA: 22.6	5izjB-4pwnA: 25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4pwn	SERINE/THREONINE-PRO TEIN KINASE WNK1 (Homo sapiens)	PF00069 (Pkinase)	5	GLY A 228 GLY A 230 SER A 231 VAL A 235 LEU A 252	None	0.36A	5izjB-4pwnA: 22.6	5izjB-4pwnA: 25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4q38	PUTATIVE UNCHARACTERIZED PROTEIN TCP24 (Actinoplanes teichomyceticus)	no annotation	5	GLY A 234 SER A 235 GLY A 318 VAL A 320 LEU A 262	TEC A 404 ( 3.9A) None None None None	1.28A	5izjB-4q38A: undetectable	5izjB-4q38A: 20.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4q9z	HUMAN PROTEIN KINASE C THETA (Homo sapiens)	PF00069 (Pkinase) PF00433 (Pkinase_C)	5	GLY A 387 GLY A 389 GLY A 392 VAL A 394 LEU A 411	PZW A 801 ( 3.8A) None None PZW A 801 (-4.6A) None	0.77A	5izjB-4q9zA: 35.2	5izjB-4q9zA: 37.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4q9z	HUMAN PROTEIN KINASE C THETA (Homo sapiens)	PF00069 (Pkinase) PF00433 (Pkinase_C)	5	GLY A 387 GLY A 389 SER A 390 GLY A 392 LEU A 411	PZW A 801 ( 3.8A) None None None None	1.06A	5izjB-4q9zA: 35.2	5izjB-4q9zA: 37.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4qny	MITOGEN ACTIVATED PROTEIN KINASE, PUTATIVE (Leishmania donovani)	PF00069 (Pkinase)	4	GLY A 28 GLY A 30 SER A 31 GLY A 33	ANP A 402 ( 3.7A) ANP A 402 (-3.4A) None None	0.21A	5izjB-4qnyA: 25.7	5izjB-4qnyA: 25.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4qtb	MITOGEN-ACTIVATED PROTEIN KINASE 3 (Homo sapiens)	PF00069 (Pkinase)	4	GLY A 49 GLY A 51 GLY A 54 VAL A 56	None	0.37A	5izjB-4qtbA: 19.1	5izjB-4qtbA: 26.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4ra4	PROTEIN KINASE C (Homo sapiens)	PF00069 (Pkinase) PF00433 (Pkinase_C)	6	GLY A 346 GLY A 348 SER A 349 GLY A 351 VAL A 353 LEU A 370	3KZ A 701 (-3.3A) None None None 3KZ A 701 (-3.9A) None	0.71A	5izjB-4ra4A: 37.3	5izjB-4ra4A: 36.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4rew	5'-AMP-ACTIVATED PROTEIN KINASE CATALYTIC SUBUNIT ALPHA-1 (Homo sapiens)	PF00069 (Pkinase) PF16579 (AdenylateSensor)	5	GLY A 25 GLY A 27 PHE A 29 GLY A 30 LEU A 49	STU A 601 (-3.5A) STU A 601 (-3.4A) None None None	1.06A	5izjB-4rewA: 30.8	5izjB-4rewA: 23.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4wb7	DNAJ HOMOLOG SUBFAMILY B MEMBER 1,CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA (Homo sapiens)	PF00069 (Pkinase) PF00226 (DnaJ)	5	GLY A 105 GLY A 107 GLY A 110 VAL A 112 LEU A 129	ATP A 501 (-3.5A) ATP A 501 (-3.2A) ATP A 501 (-3.8A) ATP A 501 (-4.0A) None	0.62A	5izjB-4wb7A: 45.9	5izjB-4wb7A: 84.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4wb7	DNAJ HOMOLOG SUBFAMILY B MEMBER 1,CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA (Homo sapiens)	PF00069 (Pkinase) PF00226 (DnaJ)	5	GLY A 105 GLY A 107 SER A 108 GLY A 110 VAL A 112	ATP A 501 (-3.5A) ATP A 501 (-3.2A) ATP A 501 (-3.7A) ATP A 501 (-3.8A) ATP A 501 (-4.0A)	0.65A	5izjB-4wb7A: 45.9	5izjB-4wb7A: 84.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4wbo	RHODOPSIN KINASE (Bos taurus)	PF00069 (Pkinase) PF00615 (RGS)	5	GLY A 194 GLY A 196 GLY A 199 VAL A 201 LEU A 218	None	0.50A	5izjB-4wboA: 35.6	5izjB-4wboA: 27.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4xk8	PUTATIVE UNCHARACTERIZED PROTEIN (Pisum sativum)	PF02605 (PsaL)	5	GLY L 49 GLY L 142 SER L 145 GLY L 143 VAL L 52	None None BCR L 206 (-3.2A) None CLA L 203 (-3.3A)	1.32A	5izjB-4xk8L: undetectable	5izjB-4xk8L: 18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4xuf	RECEPTOR-TYPE TYROSINE-PROTEIN KINASE FLT3 (Homo sapiens)	PF07714 (Pkinase_Tyr)	4	GLY A 617 GLY A 619 GLY A 622 VAL A 624	None None None P30 A1001 ( 4.8A)	0.17A	5izjB-4xufA: 15.0	5izjB-4xufA: 24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4yff	SERINE/THREONINE-PRO TEIN KINASE TNNI3K (Homo sapiens)	PF07714 (Pkinase_Tyr)	4	GLY A 470 GLY A 472 GLY A 475 VAL A 477	4CV A 801 ( 3.9A) None None None	0.36A	5izjB-4yffA: 15.3	5izjB-4yffA: 24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4yk6	ADENOMATOUS POLYPOSIS COLI PROTEIN (Homo sapiens)	PF00514 (Arm) PF16629 (Arm_APC_u3)	5	GLY A 618 GLY A 635 SER A 634 GLY A 636 VAL A 617	None	1.44A	5izjB-4yk6A: undetectable	5izjB-4yk6A: 21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ylj	DUAL SPECIFICITY TYROSINE-PHOSPHORYLA TION-REGULATED KINASE 1A (Homo sapiens)	PF00069 (Pkinase)	5	GLY A 166 GLY A 168 SER A 169 GLY A 171 VAL A 173	4E1 A 505 (-3.5A) 4E1 A 505 ( 4.9A) None None 4E1 A 505 (-4.5A)	0.61A	5izjB-4yljA: 24.5	5izjB-4yljA: 25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ahk	ACETOLACTATE SYNTHASE II, LARGE SUBUNIT (Pseudomonas protegens)	PF00205 (TPP_enzyme_M) PF02775 (TPP_enzyme_C) PF02776 (TPP_enzyme_N)	5	GLY A 395 GLY A 445 GLY A 448 VAL A 394 LEU A 451	TPP A 700 (-3.4A) TPP A 700 (-3.6A) TPP A 700 (-3.7A) TPP A 700 (-4.9A) None	1.42A	5izjB-5ahkA: undetectable	5izjB-5ahkA: 22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5d4o	NITROGEN REGULATORY PROTEIN P-II (Thiomonas intermedia)	PF00543 (P-II)	4	GLY A 44 GLY A 46 SER A 47 GLY A 49	ADP A 201 (-2.8A) ADP A 201 (-2.9A) ADP A 201 (-2.4A) ADP A 201 (-4.3A)	0.31A	5izjB-5d4oA: undetectable	5izjB-5d4oA: 17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5d79	BERBERINE BRIDGE ENZYME-LIKE PROTEIN (Arabidopsis thaliana)	PF01565 (FAD_binding_4) PF08031 (BBE)	5	GLY A 181 GLY A 185 PHE A 417 GLY A 186 LEU A 197	FAD A 603 (-3.2A) None None None None	1.26A	5izjB-5d79A: undetectable	5izjB-5d79A: 20.30

[["5IZJ_F_AZ1F2_1","1dqw","Saccharomyces cerevisiae","OROTIDINE 5'-PHOSPHATE DECARBOXYLASE","PF00215(OMPdecase)",5,"GLY A 203;GLY A 214;GLY A 234;VAL A 204;LEU A 237","None","1.37A","5izjB-1dqwA:undetectable","5izjB-1dqwA:23.33"],["5IZJ_F_AZ1F2_1","1fot","Saccharomyces cerevisiae","CAMP-DEPENDENT PROTEIN KINASE TYPE 1","PF00069(Pkinase)",5,"GLY A  94;GLY A  96;SER A  97;GLY A  99;LEU A 118","None","0.83A","5izjB-1fotA:39.6","5izjB-1fotA:45.76"],["5IZJ_F_AZ1F2_1","1gng","Homo sapiens","GLYCOGEN SYNTHASE KINASE-3 BETA","PF00069(Pkinase)",5,"GLY A  63;GLY A  65;SER A  66;GLY A  68;VAL A  70","None","0.64A","5izjB-1gngA:24.9","5izjB-1gngA:23.50"],["5IZJ_F_AZ1F2_1","1gzk","Homo sapiens","RAC-BETA SERINE\/THREONINE PROTEIN KINASE","PF00069(Pkinase);PF00433(Pkinase_C)",5,"GLY A 159;GLY A 161;GLY A 164;VAL A 166;LEU A 183","None","0.32A","5izjB-1gzkA:29.8","5izjB-1gzkA:39.60"],["5IZJ_F_AZ1F2_1","1kob","Aplysia californica","TWITCHIN","PF00069(Pkinase)",4,"GLY A  60;GLY A  62;GLY A  65;VAL A  67","None","0.26A","5izjB-1kobA:25.4","5izjB-1kobA:26.72"],["5IZJ_F_AZ1F2_1","1q18","Escherichia coli","GLUCOKINASE","PF02685(Glucokinase)",5,"GLY A 242;PHE A 244;GLY A 245;VAL A 296;LEU A 248","None","1.34A","5izjB-1q18A:undetectable","5izjB-1q18A:22.43"],["5IZJ_F_AZ1F2_1","1rjb","Homo sapiens","FL CYTOKINE RECEPTOR","PF07714(Pkinase_Tyr)",4,"GLY A 617;GLY A 619;GLY A 622;VAL A 624","None","0.30A","5izjB-1rjbA:20.8","5izjB-1rjbA:24.69"],["5IZJ_F_AZ1F2_1","1t46","Homo sapiens","HOMO SAPIENS V-KIT HARDY-ZUCKERMAN 4 FELINE SARCOMA VIRAL ONCOGENE HOMOLOG","PF07714(Pkinase_Tyr)",4,"GLY A 596;GLY A 598;GLY A 601;VAL A 603","None;None;None;STI A   3 ( 4.6A)","0.34A","5izjB-1t46A:15.7","5izjB-1t46A:24.27"],["5IZJ_F_AZ1F2_1","1tki","Homo sapiens","TITIN","PF00069(Pkinase)",4,"GLY A  31;GLY A  33;GLY A  36;VAL A  38","None","0.37A","5izjB-1tkiA:25.4","5izjB-1tkiA:25.69"],["5IZJ_F_AZ1F2_1","1u59","Homo sapiens","TYROSINE-PROTEIN KINASE ZAP-70","PF07714(Pkinase_Tyr)",4,"GLY A 345;GLY A 347;GLY A 350;VAL A 352","STU A 100 (-3.3A);None;None;STU A 100 (-4.8A)","0.27A","5izjB-1u59A:24.0","5izjB-1u59A:22.25"],["5IZJ_F_AZ1F2_1","1u5q","Rattus norvegicus","SERINE\/THREONINE PROTEIN KINASE TAO2","PF00069(Pkinase)",5,"GLY A  35;GLY A  37;SER A  38;GLY A  40;VAL A  42","None","0.64A","5izjB-1u5qA:27.7","5izjB-1u5qA:25.32"],["5IZJ_F_AZ1F2_1","1v9t","Escherichia coli","CYCLOPHILIN B","PF00160(Pro_isomerase)",5,"GLY A  86;PHE A 125;GLY A 126;VAL A 128;LEU A  20","None","0.82A","5izjB-1v9tA:undetectable","5izjB-1v9tA:18.04"],["5IZJ_F_AZ1F2_1","1zy4","Saccharomyces cerevisiae","SERINE\/THREONINE-PROTEIN KINASE GCN2","PF00069(Pkinase)",4,"GLY A 606;GLY A 608;GLY A 611;VAL A 613","None","0.17A","5izjB-1zy4A:21.0","5izjB-1zy4A:25.79"],["5IZJ_F_AZ1F2_1","2c7z","Arabidopsis thaliana","3-KETOACYL-COA THIOLASE 2","PF00108(Thiolase_N);PF02803(Thiolase_C)",4,"GLY A 162;GLY A 164;GLY A 299;VAL A 301","None","0.34A","5izjB-2c7zA:undetectable","5izjB-2c7zA:22.66"],["5IZJ_F_AZ1F2_1","2cw5","Thermus thermophilus","BACTERIAL FLUORINATING ENZYME HOMOLOG","PF01887(SAM_adeno_trans)",5,"GLY A 238;GLY A 185;PHE A 181;VAL A 235;LEU A 246","None","1.46A","5izjB-2cw5A:undetectable","5izjB-2cw5A:20.88"],["5IZJ_F_AZ1F2_1","2eu9","Homo sapiens","DUAL SPECIFICITY PROTEIN KINASE CLK3","PF00069(Pkinase)",4,"GLY A 163;GLY A 165;GLY A 168;VAL A 170","None","0.30A","5izjB-2eu9A:25.6","5izjB-2eu9A:23.70"],["5IZJ_F_AZ1F2_1","2g04","Mycobacterium tuberculosis","PROBABLE FATTY-ACID-COA RACEMASE FAR","PF02515(CoA_transf_3)",5,"GLY A 193;GLY A 162;PHE A 159;GLY A 160;VAL A 194","None","0.98A","5izjB-2g04A:undetectable","5izjB-2g04A:22.17"],["5IZJ_F_AZ1F2_1","2g04","Mycobacterium tuberculosis","PROBABLE FATTY-ACID-COA RACEMASE FAR","PF02515(CoA_transf_3)",5,"GLY A 193;GLY A 162;SER A 163;GLY A 160;VAL A 194","None","1.13A","5izjB-2g04A:undetectable","5izjB-2g04A:22.17"],["5IZJ_F_AZ1F2_1","2gcd","Rattus norvegicus","SERINE\/THREONINE-PROTEIN KINASE TAO2","PF00069(Pkinase)",5,"GLY A  35;GLY A  37;SER A  38;GLY A  40;VAL A  42","STU A 400 (-3.3A);None;None;None;STU A 400 ( 4.8A)","0.69A","5izjB-2gcdA:27.7","5izjB-2gcdA:26.20"],["5IZJ_F_AZ1F2_1","2h8h","Homo sapiens","PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC","PF00017(SH2);PF00018(SH3_1);PF07714(Pkinase_Tyr)",5,"GLY A 274;GLY A 276;GLY A 279;VAL A 281;LEU A 297","H8H A 534 ( 3.8A);None;None;H8H A 534 (-4.4A);None","0.43A","5izjB-2h8hA:21.4","5izjB-2h8hA:22.12"],["5IZJ_F_AZ1F2_1","2hk5","Homo sapiens","TYROSINE-PROTEIN KINASE HCK","PF07714(Pkinase_Tyr)",4,"GLY A 252;GLY A 254;GLY A 257;VAL A 259","None;None;None;1BM A 499 ( 4.8A)","0.24A","5izjB-2hk5A:17.5","5izjB-2hk5A:23.82"],["5IZJ_F_AZ1F2_1","2hnh","Escherichia coli","DNA POLYMERASE III ALPHA SUBUNIT","PF02811(PHP);PF07733(DNA_pol3_alpha);PF14579(HHH_6)",5,"GLY A 140;GLY A 134;GLY A 133;VAL A 139;LEU A  84","None;PO4 A 911 ( 4.1A);None;None;None","1.34A","5izjB-2hnhA:undetectable","5izjB-2hnhA:17.43"],["5IZJ_F_AZ1F2_1","2i0e","Homo sapiens","PROTEIN KINASE C-BETA II","PF00069(Pkinase);PF00433(Pkinase_C)",5,"GLY A 349;GLY A 351;SER A 352;GLY A 354;LEU A 373","PDS A 901 ( 3.7A);None;None;None;None","1.32A","5izjB-2i0eA:37.2","5izjB-2i0eA:36.86"],["5IZJ_F_AZ1F2_1","2jam","Homo sapiens","CALCIUM\/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 1G","PF00069(Pkinase)",4,"GLY A  30;GLY A  32;PHE A  34;VAL A  37","None;None;None;J60 A1305 (-4.8A)","0.26A","5izjB-2jamA:20.1","5izjB-2jamA:30.46"],["5IZJ_F_AZ1F2_1","2og8","Homo sapiens","PROTO-ONCOGENE TYROSINE-PROTEIN KINASE LCK","PF07714(Pkinase_Tyr)",4,"GLY A 252;GLY A 254;GLY A 257;VAL A 259","None","0.25A","5izjB-2og8A:22.2","5izjB-2og8A:23.20"],["5IZJ_F_AZ1F2_1","2ogv","Homo sapiens","MACROPHAGE COLONY-STIMULATING FACTOR 1 RECEPTOR PRECURSOR","PF07714(Pkinase_Tyr)",4,"GLY A 589;GLY A 591;GLY A 594;VAL A 596","None","0.22A","5izjB-2ogvA:21.1","5izjB-2ogvA:25.00"],["5IZJ_F_AZ1F2_1","2r4b","Homo sapiens","RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4","PF07714(Pkinase_Tyr)",5,"GLY A 725;GLY A 727;GLY A 730;VAL A 732;LEU A 753","None;None;None;GW7 A   1 ( 4.8A);None","0.85A","5izjB-2r4bA:11.1","5izjB-2r4bA:24.87"],["5IZJ_F_AZ1F2_1","2wtk","Homo sapiens","SERINE\/THREONINE-PROTEIN KINASE 11","PF00069(Pkinase)",5,"GLY C  56;GLY C  58;SER C  59;GLY C  61;VAL C  63","ANP C   2 (-3.3A);ANP C   2 (-3.0A);None;ANP C   2 (-3.8A);ANP C   2 (-4.2A)","0.69A","5izjB-2wtkC:29.8","5izjB-2wtkC:28.41"],["5IZJ_F_AZ1F2_1","2xk9","Homo sapiens","CHECKPOINT KINASE 2","PF00069(Pkinase)",4,"GLY A 227;GLY A 229;GLY A 232;VAL A 234","XK9 A1511 ( 4.5A);None;None;XK9 A1511 (-4.8A)","0.37A","5izjB-2xk9A:23.6","5izjB-2xk9A:34.26"],["5IZJ_F_AZ1F2_1","2xyu","Mus musculus","EPHRIN TYPE-A RECEPTOR 4,","PF07714(Pkinase_Tyr)",4,"GLY A 628;GLY A 630;GLY A 633;VAL A 635","None;None;None;Q9G A1898 ( 4.7A)","0.33A","5izjB-2xyuA:17.5","5izjB-2xyuA:24.59"],["5IZJ_F_AZ1F2_1","2z8c","Homo sapiens","INSULIN RECEPTOR","PF07714(Pkinase_Tyr)",5,"GLY A1003;GLY A1005;SER A1006;PHE A1007;GLY A1008","S91 A   1 ( 3.9A);None;None;None;None","0.79A","5izjB-2z8cA:24.6","5izjB-2z8cA:23.39"],["5IZJ_F_AZ1F2_1","2zv7","Mus musculus","TYROSINE-PROTEIN KINASE LYN","PF07714(Pkinase_Tyr)",4,"GLY A 254;GLY A 256;GLY A 259;VAL A 261","None","0.34A","5izjB-2zv7A:24.1","5izjB-2zv7A:23.86"],["5IZJ_F_AZ1F2_1","3cea","Lactobacillus plantarum","MYO-INOSITOL 2-DEHYDROGENASE","PF01408(GFO_IDH_MocA);PF02894(GFO_IDH_MocA_C)",4,"GLY A 257;SER A 258;GLY A 260;VAL A 262","None","0.36A","5izjB-3ceaA:undetectable","5izjB-3ceaA:21.88"],["5IZJ_F_AZ1F2_1","3coi","Homo sapiens","MITOGEN-ACTIVATED PROTEIN KINASE 13","PF00069(Pkinase)",5,"GLY A  32;GLY A  34;GLY A  37;VAL A  39;LEU A  56","None","0.81A","5izjB-3coiA:22.6","5izjB-3coiA:27.13"],["5IZJ_F_AZ1F2_1","3dm0","Arabidopsis thaliana;Escherichia coli","MALTOSE-BINDING PERIPLASMIC PROTEIN FUSED WITH RACK1","PF00400(WD40);PF01547(SBP_bac_1)",5,"GLY A1213;SER A1198;GLY A1212;VAL A1217;LEU A1241","None","1.44A","5izjB-3dm0A:undetectable","5izjB-3dm0A:19.41"],["5IZJ_F_AZ1F2_1","3f3z","Cryptosporidium parvum","CALCIUM\/CALMODULIN-DEPENDENT PROTEIN KINASE WITH A KINASE DOMAIN AND 4 CALMODULIN LIKE EF HANDS","PF00069(Pkinase)",5,"GLY A  35;GLY A  37;SER A  38;GLY A  40;VAL A  42","DRK A   1 ( 3.9A);None;None;None;DRK A   1 ( 4.9A)","0.76A","5izjB-3f3zA:30.0","5izjB-3f3zA:28.94"],["5IZJ_F_AZ1F2_1","3fhh","Shigella dysenteriae","OUTER MEMBRANE HEME RECEPTOR SHUA","PF00593(TonB_dep_Rec);PF07715(Plug)",4,"GLY A 143;GLY A 145;VAL A 636;LEU A 609","None","0.36A","5izjB-3fhhA:undetectable","5izjB-3fhhA:19.38"],["5IZJ_F_AZ1F2_1","3hdn","Homo sapiens","SERINE\/THREONINE-PROTEIN KINASE SGK1","PF00069(Pkinase)",5,"GLY A 105;GLY A 107;SER A 108;GLY A 110;LEU A 129","None;GMG A   1 (-3.3A);None;None;None","1.16A","5izjB-3hdnA:28.5","5izjB-3hdnA:38.76"],["5IZJ_F_AZ1F2_1","3hng","Homo sapiens","VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 1","PF07714(Pkinase_Tyr)",4,"GLY A 834;GLY A 836;GLY A 839;VAL A 841","None;None;None;8ST A2001 ( 4.6A)","0.28A","5izjB-3hngA:22.2","5izjB-3hngA:23.02"],["5IZJ_F_AZ1F2_1","3igo","Cryptosporidium parvum","CALMODULIN-DOMAIN PROTEIN KINASE 1","PF00069(Pkinase);PF13499(EF-hand_7)",4,"GLY A  83;GLY A  85;SER A  86;GLY A  88","ANP A 610 (-3.5A);ANP A 610 (-2.9A);ANP A 610 (-2.6A);ANP A 610 (-4.5A)","0.28A","5izjB-3igoA:23.3","5izjB-3igoA:25.39"],["5IZJ_F_AZ1F2_1","3is5","Toxoplasma gondii","CALCIUM-DEPENDENT PROTEIN KINASE","PF00069(Pkinase)",5,"GLY A 142;GLY A 144;PHE A 146;GLY A 147;VAL A 149","ANP A   1 (-3.5A);ANP A   1 (-3.4A);None;None;ANP A   1 (-4.9A)","0.81A","5izjB-3is5A:19.5","5izjB-3is5A:25.41"],["5IZJ_F_AZ1F2_1","3kex","Homo sapiens","RECEPTOR TYROSINE-PROTEIN KINASE ERBB-3","PF07714(Pkinase_Tyr)",5,"GLY A 697;GLY A 699;PHE A 701;GLY A 702;VAL A 704","ANP A   1 (-3.7A);ANP A   1 (-2.8A);None;None;ANP A   1 (-3.9A)","0.56A","5izjB-3kexA:19.4","5izjB-3kexA:25.13"],["5IZJ_F_AZ1F2_1","3l9y","Bombyx mori","SUPEROXIDE DISMUTASE [CU-ZN]","PF00080(Sod_Cu)",5,"GLY A  32;GLY A  15;SER A  14;VAL A  97;LEU A  37","None","1.36A","5izjB-3l9yA:undetectable","5izjB-3l9yA:18.75"],["5IZJ_F_AZ1F2_1","3lzb","Homo sapiens","EPIDERMAL GROWTH FACTOR RECEPTOR","PF07714(Pkinase_Tyr)",5,"GLY A 695;GLY A 697;GLY A 700;VAL A 702;LEU A 723","ITI A   1 ( 4.8A);None;None;ITI A   1 (-4.8A);None","0.76A","5izjB-3lzbA:20.1","5izjB-3lzbA:22.86"],["5IZJ_F_AZ1F2_1","3mvj","Homo sapiens","CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA","PF00069(Pkinase)",5,"GLY A  50;GLY A  52;GLY A  55;VAL A  57;LEU A  74","XFE A 351 ( 4.0A);None;None;XFE A 351 ( 4.5A);None","0.45A","5izjB-3mvjA:46.1","5izjB-3mvjA:94.61"],["5IZJ_F_AZ1F2_1","3mvj","Homo sapiens","CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA","PF00069(Pkinase)",5,"GLY A  50;GLY A  52;SER A  53;GLY A  55;VAL A  57","XFE A 351 ( 4.0A);None;None;None;XFE A 351 ( 4.5A)","0.54A","5izjB-3mvjA:46.1","5izjB-3mvjA:94.61"],["5IZJ_F_AZ1F2_1","3mvj","Homo sapiens","CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA","PF00069(Pkinase)",5,"GLY A  50;GLY A  52;SER A  53;PHE A  54;GLY A  55","XFE A 351 ( 4.0A);None;None;None;None","1.00A","5izjB-3mvjA:46.1","5izjB-3mvjA:94.61"],["5IZJ_F_AZ1F2_1","3my0","Homo sapiens","SERINE\/THREONINE-PROTEIN KINASE RECEPTOR R3","PF07714(Pkinase_Tyr)",4,"GLY A 209;GLY A 211;GLY A 214;VAL A 216","None;None;None;LDN A 600 (-4.5A)","0.33A","5izjB-3my0A:21.1","5izjB-3my0A:21.24"],["5IZJ_F_AZ1F2_1","3o96","Homo sapiens","RAC-ALPHA SERINE\/THREONINE-PROTEIN KINASE","PF00069(Pkinase);PF00169(PH)",5,"GLY A 157;GLY A 159;GLY A 162;VAL A 164;LEU A 181","GLY A 157 ( 0.0A);GLY A 159 ( 0.0A);GLY A 162 ( 0.0A);VAL A 164 ( 0.6A);LEU A 181 ( 0.6A)","0.19A","5izjB-3o96A:30.4","5izjB-3o96A:34.20"],["5IZJ_F_AZ1F2_1","3ppz","Arabidopsis thaliana","SERINE\/THREONINE-PROTEIN KINASE CTR1","PF07714(Pkinase_Tyr)",6,"GLY A 558;GLY A 560;SER A 561;GLY A 563;VAL A 565;LEU A 580","STU A   1 (-3.2A);None;None;None;STU A   1 (-4.9A);None","0.65A","5izjB-3ppzA:26.1","5izjB-3ppzA:26.70"],["5IZJ_F_AZ1F2_1","3qfv","Homo sapiens","CDC42BPB PROTEIN","PF00069(Pkinase)",4,"GLY A  83;GLY A  88;VAL A  90;LEU A 107","NM7 A 416 (-3.0A);None;NM7 A 416 (-3.7A);EDO A 417 (-4.6A)","0.33A","5izjB-3qfvA:30.8","5izjB-3qfvA:33.17"],["5IZJ_F_AZ1F2_1","3sv0","Oryza sativa","CASEIN KINASE I-LIKE","PF00069(Pkinase)",4,"GLY A  16;GLY A  18;SER A  19;GLY A  21","None","0.37A","5izjB-3sv0A:18.8","5izjB-3sv0A:22.49"],["5IZJ_F_AZ1F2_1","3txo","Homo sapiens","PROTEIN KINASE C ETA TYPE","PF00069(Pkinase);PF00433(Pkinase_C)",6,"GLY A 362;GLY A 364;SER A 365;GLY A 367;VAL A 369;LEU A 386","07U A   1 ( 4.2A);None;None;None;07U A   1 (-4.8A);None","0.80A","5izjB-3txoA:31.6","5izjB-3txoA:39.23"],["5IZJ_F_AZ1F2_1","3upg","Salmonella enterica","OUTER MEMBRANE PROTEIN C","PF00267(Porin_1)",5,"GLY A  52;GLY A  54;PHE A  40;GLY A  42;LEU A  11","None","0.94A","5izjB-3upgA:undetectable","5izjB-3upgA:20.54"],["5IZJ_F_AZ1F2_1","3uto","Caenorhabditis elegans","TWITCHIN","PF00041(fn3);PF00069(Pkinase);PF07679(I-set)",4,"GLY A 163;GLY A 165;GLY A 168;VAL A 170","None","0.26A","5izjB-3utoA:25.7","5izjB-3utoA:22.39"],["5IZJ_F_AZ1F2_1","3vid","Homo sapiens","VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2","PF07714(Pkinase_Tyr)",4,"GLY A 841;GLY A 843;GLY A 846;VAL A 848","4TT A2001 ( 4.8A);None;None;4TT A2001 ( 4.5A)","0.22A","5izjB-3vidA:21.1","5izjB-3vidA:22.45"],["5IZJ_F_AZ1F2_1","3vte","Cannabis sativa","TETRAHYDROCANNABINOLIC ACID SYNTHASE","PF01565(FAD_binding_4);PF08031(BBE)",5,"GLY A 183;GLY A 187;PHE A 433;GLY A 188;LEU A 199","FAD A 607 (-3.1A);None;None;None;None","1.27A","5izjB-3vteA:undetectable","5izjB-3vteA:19.77"],["5IZJ_F_AZ1F2_1","3wz2","Pyrococcus furiosus","UNCHARACTERIZED PROTEIN","PF09754(PAC2)",5,"GLY A 132;SER A 133;GLY A 131;VAL A 173;LEU A 140","None","1.17A","5izjB-3wz2A:undetectable","5izjB-3wz2A:22.71"],["5IZJ_F_AZ1F2_1","3zdu","Homo sapiens","CYCLIN-DEPENDENT KINASE-LIKE 3","PF00069(Pkinase)",4,"GLY A  11;GLY A  13;GLY A  16;VAL A  18","38R A 350 ( 3.9A);None;None;38R A 350 ( 4.8A)","0.33A","5izjB-3zduA:24.4","5izjB-3zduA:31.76"],["5IZJ_F_AZ1F2_1","4agd","Homo sapiens","VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2","PF07714(Pkinase_Tyr)",4,"GLY A 841;GLY A 843;GLY A 846;VAL A 848","B49 A2000 ( 4.6A);None;None;None","0.29A","5izjB-4agdA:21.0","5izjB-4agdA:23.21"],["5IZJ_F_AZ1F2_1","4agu","Homo sapiens","CYCLIN-DEPENDENT KINASE-LIKE 1","PF00069(Pkinase)",4,"GLY A  11;GLY A  13;GLY A  16;VAL A  18","D15 A 500 (-3.8A);D15 A 500 (-3.6A);D15 A 500 (-3.7A);D15 A 500 (-4.6A)","0.29A","5izjB-4aguA:25.9","5izjB-4aguA:24.86"],["5IZJ_F_AZ1F2_1","4aw2","Rattus norvegicus","SERINE\/THREONINE-PROTEIN KINASE MRCK ALPHA","PF00069(Pkinase);PF00433(Pkinase_C)",5,"GLY A  84;GLY A  86;GLY A  89;VAL A  91;LEU A 108","None;None;None;None;EDO A1419 (-4.2A)","0.30A","5izjB-4aw2A:31.7","5izjB-4aw2A:31.28"],["5IZJ_F_AZ1F2_1","4c02","Homo sapiens","ACTIVIN RECEPTOR TYPE-1","PF00069(Pkinase);PF08515(TGF_beta_GS)",4,"GLY A 215;GLY A 217;GLY A 220;VAL A 222","None;None;None;TAK A1507 (-4.7A)","0.29A","5izjB-4c02A:21.8","5izjB-4c02A:21.47"],["5IZJ_F_AZ1F2_1","4c0t","Candida albicans","LIKELY PROTEIN KINASE","PF00069(Pkinase)",4,"GLY A 247;GLY A 249;VAL A 254;LEU A 271","None","0.30A","5izjB-4c0tA:30.2","5izjB-4c0tA:18.33"],["5IZJ_F_AZ1F2_1","4d65","Providencia stuartii","PORIN 2","PF00267(Porin_1)",5,"GLY A  53;GLY A  55;PHE A  41;GLY A  43;LEU A  11","None","0.86A","5izjB-4d65A:undetectable","5izjB-4d65A:20.48"],["5IZJ_F_AZ1F2_1","4e7w","Ustilago maydis","GLYCOGEN SYNTHASE KINASE 3","PF00069(Pkinase)",5,"GLY A  45;GLY A  47;SER A  48;GLY A  50;VAL A  52","None","1.09A","5izjB-4e7wA:24.8","5izjB-4e7wA:27.43"],["5IZJ_F_AZ1F2_1","4f0i","Homo sapiens","HIGH AFFINITY NERVE GROWTH FACTOR RECEPTOR","PF07714(Pkinase_Tyr)",4,"GLY A 516;GLY A 518;GLY A 521;VAL A 523","None","0.25A","5izjB-4f0iA:15.0","5izjB-4f0iA:23.62"],["5IZJ_F_AZ1F2_1","4fr4","Homo sapiens","SERINE\/THREONINE-PROTEIN KINASE 32A","PF00069(Pkinase)",5,"GLY A  30;GLY A  32;SER A  33;GLY A  35;VAL A  37","STU A 401 (-3.3A);None;None;None;STU A 401 ( 4.9A)","0.60A","5izjB-4fr4A:32.3","5izjB-4fr4A:29.51"],["5IZJ_F_AZ1F2_1","4g34","Homo sapiens","EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE 3","PF00069(Pkinase)",4,"GLY A 599;GLY A 601;GLY A 604;VAL A 606","None;None;None;924 A1101 ( 4.8A)","0.34A","5izjB-4g34A:21.7","5izjB-4g34A:24.21"],["5IZJ_F_AZ1F2_1","4gv1","Homo sapiens","RAC-ALPHA SERINE\/THREONINE-PROTEIN KINASE","PF00069(Pkinase);PF00433(Pkinase_C)",5,"GLY A 157;GLY A 159;GLY A 162;VAL A 164;LEU A 181","GOL A 505 ( 3.4A);0XZ A 501 (-4.1A);0XZ A 501 (-3.8A);0XZ A 501 (-4.5A);GOL A 503 (-4.9A)","0.29A","5izjB-4gv1A:37.5","5izjB-4gv1A:38.24"],["5IZJ_F_AZ1F2_1","4hvi","Homo sapiens","TYROSINE-PROTEIN KINASE JAK3","PF07714(Pkinase_Tyr)",4,"GLY A 829;GLY A 831;GLY A 834;VAL A 836","19S A1201 (-3.7A);19S A1201 ( 4.3A);19S A1201 ( 4.9A);19S A1201 (-4.4A)","0.27A","5izjB-4hviA:23.6","5izjB-4hviA:24.60"],["5IZJ_F_AZ1F2_1","4idt","Homo sapiens","MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 14","PF00069(Pkinase)",4,"GLY A 407;GLY A 409;SER A 410;GLY A 412","T28 A 701 ( 3.6A);T28 A 701 ( 3.0A);None;None","0.31A","5izjB-4idtA:23.6","5izjB-4idtA:24.62"],["5IZJ_F_AZ1F2_1","4k11","Homo sapiens","PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC","PF00017(SH2);PF00018(SH3_1);PF07714(Pkinase_Tyr)",5,"GLY A 274;GLY A 276;GLY A 279;VAL A 281;LEU A 297","0J9 A 601 ( 4.0A);None;None;0J9 A 601 (-4.4A);None","0.57A","5izjB-4k11A:20.9","5izjB-4k11A:22.17"],["5IZJ_F_AZ1F2_1","4k33","Homo sapiens","FIBROBLAST GROWTH FACTOR RECEPTOR 3","PF07714(Pkinase_Tyr)",4,"GLY A 479;GLY A 481;GLY A 484;VAL A 486","ACP A 801 (-3.4A);ACP A 801 (-3.6A);ACP A 801 (-3.6A);ACP A 801 (-4.2A)","0.34A","5izjB-4k33A:18.8","5izjB-4k33A:25.45"],["5IZJ_F_AZ1F2_1","4ks8","Homo sapiens","SERINE\/THREONINE-PROTEIN KINASE PAK 6","PF00069(Pkinase)",5,"GLY A 414;GLY A 416;SER A 417;GLY A 419;VAL A 421","B49 A 701 ( 4.3A);None;None;None;None","0.71A","5izjB-4ks8A:28.1","5izjB-4ks8A:27.43"],["5IZJ_F_AZ1F2_1","4l9o","Komagataella pastoris;Komagataella phaffii","SEC16,PROTEIN TRANSPORT PROTEIN SEC13","PF00400(WD40)",4,"GLY A1077;SER A1078;GLY A1085;VAL A2013","None","0.32A","5izjB-4l9oA:undetectable","5izjB-4l9oA:21.54"],["5IZJ_F_AZ1F2_1","4lgg","Gallus gallus","PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC","PF07714(Pkinase_Tyr)",4,"GLY A 274;GLY A 276;GLY A 279;VAL A 281","VGG A 601 ( 3.8A);None;None;VGG A 601 ( 3.5A)","0.26A","5izjB-4lggA:20.1","5izjB-4lggA:23.91"],["5IZJ_F_AZ1F2_1","4mk0","Homo sapiens","BETA-ADRENERGIC RECEPTOR KINASE 1","PF00069(Pkinase);PF00169(PH);PF00615(RGS)",5,"GLY A 198;GLY A 200;GLY A 203;VAL A 205;LEU A 222","29X A 702 ( 4.1A);29X A 702 (-3.6A);29X A 702 (-3.5A);29X A 702 (-4.7A);None","0.40A","5izjB-4mk0A:26.8","5izjB-4mk0A:25.17"],["5IZJ_F_AZ1F2_1","4otd","Homo sapiens","SERINE\/THREONINE-PROTEIN KINASE N1","PF00069(Pkinase);PF00433(Pkinase_C)",5,"GLY A 628;GLY A 630;GLY A 633;VAL A 635;LEU A 652","None","0.78A","5izjB-4otdA:36.5","5izjB-4otdA:37.43"],["5IZJ_F_AZ1F2_1","4p1e","Escherichia fergusonii","TRAP DICARBOXYLATE TRANSPORTER, DCTP SUBUNIT","PF03480(DctP)",5,"GLY A 139;SER A 138;PHE A  99;VAL A 243;LEU A  78","IOD A 404 ( 4.1A);IOD A 411 ( 3.1A);None;None;None","1.41A","5izjB-4p1eA:undetectable","5izjB-4p1eA:21.15"],["5IZJ_F_AZ1F2_1","4pwn","Homo sapiens","SERINE\/THREONINE-PROTEIN KINASE WNK1","PF00069(Pkinase)",5,"GLY A 228;GLY A 230;SER A 231;PHE A 232;LEU A 252","None","0.79A","5izjB-4pwnA:22.6","5izjB-4pwnA:25.00"],["5IZJ_F_AZ1F2_1","4pwn","Homo sapiens","SERINE\/THREONINE-PROTEIN KINASE WNK1","PF00069(Pkinase)",5,"GLY A 228;GLY A 230;SER A 231;VAL A 235;LEU A 252","None","0.36A","5izjB-4pwnA:22.6","5izjB-4pwnA:25.00"],["5IZJ_F_AZ1F2_1","4q38","Actinoplanes teichomyceticus","PUTATIVE UNCHARACTERIZED PROTEIN TCP24","no annotation",5,"GLY A 234;SER A 235;GLY A 318;VAL A 320;LEU A 262","TEC A 404 ( 3.9A);None;None;None;None","1.28A","5izjB-4q38A:undetectable","5izjB-4q38A:20.27"],["5IZJ_F_AZ1F2_1","4q9z","Homo sapiens","HUMAN PROTEIN KINASE C THETA","PF00069(Pkinase);PF00433(Pkinase_C)",5,"GLY A 387;GLY A 389;GLY A 392;VAL A 394;LEU A 411","PZW A 801 ( 3.8A);None;None;PZW A 801 (-4.6A);None","0.77A","5izjB-4q9zA:35.2","5izjB-4q9zA:37.43"],["5IZJ_F_AZ1F2_1","4q9z","Homo sapiens","HUMAN PROTEIN KINASE C THETA","PF00069(Pkinase);PF00433(Pkinase_C)",5,"GLY A 387;GLY A 389;SER A 390;GLY A 392;LEU A 411","PZW A 801 ( 3.8A);None;None;None;None","1.06A","5izjB-4q9zA:35.2","5izjB-4q9zA:37.43"],["5IZJ_F_AZ1F2_1","4qny","Leishmania donovani","MITOGEN ACTIVATED PROTEIN KINASE, PUTATIVE","PF00069(Pkinase)",4,"GLY A  28;GLY A  30;SER A  31;GLY A  33","ANP A 402 ( 3.7A);ANP A 402 (-3.4A);None;None","0.21A","5izjB-4qnyA:25.7","5izjB-4qnyA:25.77"],["5IZJ_F_AZ1F2_1","4qtb","Homo sapiens","MITOGEN-ACTIVATED PROTEIN KINASE 3","PF00069(Pkinase)",4,"GLY A  49;GLY A  51;GLY A  54;VAL A  56","None","0.37A","5izjB-4qtbA:19.1","5izjB-4qtbA:26.28"],["5IZJ_F_AZ1F2_1","4ra4","Homo sapiens","PROTEIN KINASE C","PF00069(Pkinase);PF00433(Pkinase_C)",6,"GLY A 346;GLY A 348;SER A 349;GLY A 351;VAL A 353;LEU A 370","3KZ A 701 (-3.3A);None;None;None;3KZ A 701 (-3.9A);None","0.71A","5izjB-4ra4A:37.3","5izjB-4ra4A:36.13"],["5IZJ_F_AZ1F2_1","4rew","Homo sapiens","5'-AMP-ACTIVATED PROTEIN KINASE CATALYTIC SUBUNIT ALPHA-1","PF00069(Pkinase);PF16579(AdenylateSensor)",5,"GLY A  25;GLY A  27;PHE A  29;GLY A  30;LEU A  49","STU A 601 (-3.5A);STU A 601 (-3.4A);None;None;None","1.06A","5izjB-4rewA:30.8","5izjB-4rewA:23.10"],["5IZJ_F_AZ1F2_1","4wb7","Homo sapiens","DNAJ HOMOLOG SUBFAMILY B MEMBER 1,CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA","PF00069(Pkinase);PF00226(DnaJ)",5,"GLY A 105;GLY A 107;GLY A 110;VAL A 112;LEU A 129","ATP A 501 (-3.5A);ATP A 501 (-3.2A);ATP A 501 (-3.8A);ATP A 501 (-4.0A);None","0.62A","5izjB-4wb7A:45.9","5izjB-4wb7A:84.94"],["5IZJ_F_AZ1F2_1","4wb7","Homo sapiens","DNAJ HOMOLOG SUBFAMILY B MEMBER 1,CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA","PF00069(Pkinase);PF00226(DnaJ)",5,"GLY A 105;GLY A 107;SER A 108;GLY A 110;VAL A 112","ATP A 501 (-3.5A);ATP A 501 (-3.2A);ATP A 501 (-3.7A);ATP A 501 (-3.8A);ATP A 501 (-4.0A)","0.65A","5izjB-4wb7A:45.9","5izjB-4wb7A:84.94"],["5IZJ_F_AZ1F2_1","4wbo","Bos taurus","RHODOPSIN KINASE","PF00069(Pkinase);PF00615(RGS)",5,"GLY A 194;GLY A 196;GLY A 199;VAL A 201;LEU A 218","None","0.50A","5izjB-4wboA:35.6","5izjB-4wboA:27.72"],["5IZJ_F_AZ1F2_1","4xk8","Pisum sativum","PUTATIVE UNCHARACTERIZED PROTEIN","PF02605(PsaL)",5,"GLY L  49;GLY L 142;SER L 145;GLY L 143;VAL L  52","None;None;BCR L 206 (-3.2A);None;CLA L 203 (-3.3A)","1.32A","5izjB-4xk8L:undetectable","5izjB-4xk8L:18.97"],["5IZJ_F_AZ1F2_1","4xuf","Homo sapiens","RECEPTOR-TYPE TYROSINE-PROTEIN KINASE FLT3","PF07714(Pkinase_Tyr)",4,"GLY A 617;GLY A 619;GLY A 622;VAL A 624","None;None;None;P30 A1001 ( 4.8A)","0.17A","5izjB-4xufA:15.0","5izjB-4xufA:24.25"],["5IZJ_F_AZ1F2_1","4yff","Homo sapiens","SERINE\/THREONINE-PROTEIN KINASE TNNI3K","PF07714(Pkinase_Tyr)",4,"GLY A 470;GLY A 472;GLY A 475;VAL A 477","4CV A 801 ( 3.9A);None;None;None","0.36A","5izjB-4yffA:15.3","5izjB-4yffA:24.66"],["5IZJ_F_AZ1F2_1","4yk6","Homo sapiens","ADENOMATOUS POLYPOSIS COLI PROTEIN","PF00514(Arm);PF16629(Arm_APC_u3)",5,"GLY A 618;GLY A 635;SER A 634;GLY A 636;VAL A 617","None","1.44A","5izjB-4yk6A:undetectable","5izjB-4yk6A:21.21"],["5IZJ_F_AZ1F2_1","4ylj","Homo sapiens","DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION-REGULATED KINASE 1A","PF00069(Pkinase)",5,"GLY A 166;GLY A 168;SER A 169;GLY A 171;VAL A 173","4E1 A 505 (-3.5A);4E1 A 505 ( 4.9A);None;None;4E1 A 505 (-4.5A)","0.61A","5izjB-4yljA:24.5","5izjB-4yljA:25.07"],["5IZJ_F_AZ1F2_1","5ahk","Pseudomonas protegens","ACETOLACTATE SYNTHASE II, LARGE SUBUNIT","PF00205(TPP_enzyme_M);PF02775(TPP_enzyme_C);PF02776(TPP_enzyme_N)",5,"GLY A 395;GLY A 445;GLY A 448;VAL A 394;LEU A 451","TPP A 700 (-3.4A);TPP A 700 (-3.6A);TPP A 700 (-3.7A);TPP A 700 (-4.9A);None","1.42A","5izjB-5ahkA:undetectable","5izjB-5ahkA:22.72"],["5IZJ_F_AZ1F2_1","5d4o","Thiomonas intermedia","NITROGEN REGULATORY PROTEIN P-II","PF00543(P-II)",4,"GLY A  44;GLY A  46;SER A  47;GLY A  49","ADP A 201 (-2.8A);ADP A 201 (-2.9A);ADP A 201 (-2.4A);ADP A 201 (-4.3A)","0.31A","5izjB-5d4oA:undetectable","5izjB-5d4oA:17.30"],["5IZJ_F_AZ1F2_1","5d79","Arabidopsis thaliana","BERBERINE BRIDGE ENZYME-LIKE PROTEIN","PF01565(FAD_binding_4);PF08031(BBE)",5,"GLY A 181;GLY A 185;PHE A 417;GLY A 186;LEU A 197","FAD A 603 (-3.2A);None;None;None;None","1.26A","5izjB-5d79A:undetectable","5izjB-5d79A:20.30"]]