SIMILAR PATTERNS OF AMINO ACIDS FOR 5IZJ_F_AZ1F2_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dqw OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE


(Saccharomyces
cerevisiae)
PF00215
(OMPdecase)
5 GLY A 203
GLY A 214
GLY A 234
VAL A 204
LEU A 237
None
1.37A 5izjB-1dqwA:
undetectable
5izjB-1dqwA:
23.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1fot CAMP-DEPENDENT
PROTEIN KINASE TYPE
1


(Saccharomyces
cerevisiae)
PF00069
(Pkinase)
5 GLY A  94
GLY A  96
SER A  97
GLY A  99
LEU A 118
None
0.83A 5izjB-1fotA:
39.6
5izjB-1fotA:
45.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gng GLYCOGEN SYNTHASE
KINASE-3 BETA


(Homo sapiens)
PF00069
(Pkinase)
5 GLY A  63
GLY A  65
SER A  66
GLY A  68
VAL A  70
None
0.64A 5izjB-1gngA:
24.9
5izjB-1gngA:
23.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gzk RAC-BETA
SERINE/THREONINE
PROTEIN KINASE


(Homo sapiens)
PF00069
(Pkinase)
PF00433
(Pkinase_C)
5 GLY A 159
GLY A 161
GLY A 164
VAL A 166
LEU A 183
None
0.32A 5izjB-1gzkA:
29.8
5izjB-1gzkA:
39.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kob TWITCHIN

(Aplysia
californica)
PF00069
(Pkinase)
4 GLY A  60
GLY A  62
GLY A  65
VAL A  67
None
0.26A 5izjB-1kobA:
25.4
5izjB-1kobA:
26.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q18 GLUCOKINASE

(Escherichia
coli)
PF02685
(Glucokinase)
5 GLY A 242
PHE A 244
GLY A 245
VAL A 296
LEU A 248
None
1.34A 5izjB-1q18A:
undetectable
5izjB-1q18A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rjb FL CYTOKINE RECEPTOR

(Homo sapiens)
PF07714
(Pkinase_Tyr)
4 GLY A 617
GLY A 619
GLY A 622
VAL A 624
None
0.30A 5izjB-1rjbA:
20.8
5izjB-1rjbA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG


(Homo sapiens)
PF07714
(Pkinase_Tyr)
4 GLY A 596
GLY A 598
GLY A 601
VAL A 603
None
None
None
STI  A   3 ( 4.6A)
0.34A 5izjB-1t46A:
15.7
5izjB-1t46A:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tki TITIN

(Homo sapiens)
PF00069
(Pkinase)
4 GLY A  31
GLY A  33
GLY A  36
VAL A  38
None
0.37A 5izjB-1tkiA:
25.4
5izjB-1tkiA:
25.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u59 TYROSINE-PROTEIN
KINASE ZAP-70


(Homo sapiens)
PF07714
(Pkinase_Tyr)
4 GLY A 345
GLY A 347
GLY A 350
VAL A 352
STU  A 100 (-3.3A)
None
None
STU  A 100 (-4.8A)
0.27A 5izjB-1u59A:
24.0
5izjB-1u59A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5q SERINE/THREONINE
PROTEIN KINASE TAO2


(Rattus
norvegicus)
PF00069
(Pkinase)
5 GLY A  35
GLY A  37
SER A  38
GLY A  40
VAL A  42
None
0.64A 5izjB-1u5qA:
27.7
5izjB-1u5qA:
25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v9t CYCLOPHILIN B

(Escherichia
coli)
PF00160
(Pro_isomerase)
5 GLY A  86
PHE A 125
GLY A 126
VAL A 128
LEU A  20
None
0.82A 5izjB-1v9tA:
undetectable
5izjB-1v9tA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zy4 SERINE/THREONINE-PRO
TEIN KINASE GCN2


(Saccharomyces
cerevisiae)
PF00069
(Pkinase)
4 GLY A 606
GLY A 608
GLY A 611
VAL A 613
None
0.17A 5izjB-1zy4A:
21.0
5izjB-1zy4A:
25.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c7z 3-KETOACYL-COA
THIOLASE 2


(Arabidopsis
thaliana)
PF00108
(Thiolase_N)
PF02803
(Thiolase_C)
4 GLY A 162
GLY A 164
GLY A 299
VAL A 301
None
0.34A 5izjB-2c7zA:
undetectable
5izjB-2c7zA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cw5 BACTERIAL
FLUORINATING ENZYME
HOMOLOG


(Thermus
thermophilus)
PF01887
(SAM_adeno_trans)
5 GLY A 238
GLY A 185
PHE A 181
VAL A 235
LEU A 246
None
1.46A 5izjB-2cw5A:
undetectable
5izjB-2cw5A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eu9 DUAL SPECIFICITY
PROTEIN KINASE CLK3


(Homo sapiens)
PF00069
(Pkinase)
4 GLY A 163
GLY A 165
GLY A 168
VAL A 170
None
0.30A 5izjB-2eu9A:
25.6
5izjB-2eu9A:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g04 PROBABLE
FATTY-ACID-COA
RACEMASE FAR


(Mycobacterium
tuberculosis)
PF02515
(CoA_transf_3)
5 GLY A 193
GLY A 162
PHE A 159
GLY A 160
VAL A 194
None
0.98A 5izjB-2g04A:
undetectable
5izjB-2g04A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g04 PROBABLE
FATTY-ACID-COA
RACEMASE FAR


(Mycobacterium
tuberculosis)
PF02515
(CoA_transf_3)
5 GLY A 193
GLY A 162
SER A 163
GLY A 160
VAL A 194
None
1.13A 5izjB-2g04A:
undetectable
5izjB-2g04A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gcd SERINE/THREONINE-PRO
TEIN KINASE TAO2


(Rattus
norvegicus)
PF00069
(Pkinase)
5 GLY A  35
GLY A  37
SER A  38
GLY A  40
VAL A  42
STU  A 400 (-3.3A)
None
None
None
STU  A 400 ( 4.8A)
0.69A 5izjB-2gcdA:
27.7
5izjB-2gcdA:
26.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC


(Homo sapiens)
PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr)
5 GLY A 274
GLY A 276
GLY A 279
VAL A 281
LEU A 297
H8H  A 534 ( 3.8A)
None
None
H8H  A 534 (-4.4A)
None
0.43A 5izjB-2h8hA:
21.4
5izjB-2h8hA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hk5 TYROSINE-PROTEIN
KINASE HCK


(Homo sapiens)
PF07714
(Pkinase_Tyr)
4 GLY A 252
GLY A 254
GLY A 257
VAL A 259
None
None
None
1BM  A 499 ( 4.8A)
0.24A 5izjB-2hk5A:
17.5
5izjB-2hk5A:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hnh DNA POLYMERASE III
ALPHA SUBUNIT


(Escherichia
coli)
PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6)
5 GLY A 140
GLY A 134
GLY A 133
VAL A 139
LEU A  84
None
PO4  A 911 ( 4.1A)
None
None
None
1.34A 5izjB-2hnhA:
undetectable
5izjB-2hnhA:
17.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2i0e PROTEIN KINASE
C-BETA II


(Homo sapiens)
PF00069
(Pkinase)
PF00433
(Pkinase_C)
5 GLY A 349
GLY A 351
SER A 352
GLY A 354
LEU A 373
PDS  A 901 ( 3.7A)
None
None
None
None
1.32A 5izjB-2i0eA:
37.2
5izjB-2i0eA:
36.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2jam CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1G


(Homo sapiens)
PF00069
(Pkinase)
4 GLY A  30
GLY A  32
PHE A  34
VAL A  37
None
None
None
J60  A1305 (-4.8A)
0.26A 5izjB-2jamA:
20.1
5izjB-2jamA:
30.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK


(Homo sapiens)
PF07714
(Pkinase_Tyr)
4 GLY A 252
GLY A 254
GLY A 257
VAL A 259
None
0.25A 5izjB-2og8A:
22.2
5izjB-2og8A:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR


(Homo sapiens)
PF07714
(Pkinase_Tyr)
4 GLY A 589
GLY A 591
GLY A 594
VAL A 596
None
0.22A 5izjB-2ogvA:
21.1
5izjB-2ogvA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4


(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 GLY A 725
GLY A 727
GLY A 730
VAL A 732
LEU A 753
None
None
None
GW7  A   1 ( 4.8A)
None
0.85A 5izjB-2r4bA:
11.1
5izjB-2r4bA:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtk SERINE/THREONINE-PRO
TEIN KINASE 11


(Homo sapiens)
PF00069
(Pkinase)
5 GLY C  56
GLY C  58
SER C  59
GLY C  61
VAL C  63
ANP  C   2 (-3.3A)
ANP  C   2 (-3.0A)
None
ANP  C   2 (-3.8A)
ANP  C   2 (-4.2A)
0.69A 5izjB-2wtkC:
29.8
5izjB-2wtkC:
28.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xk9 CHECKPOINT KINASE 2

(Homo sapiens)
PF00069
(Pkinase)
4 GLY A 227
GLY A 229
GLY A 232
VAL A 234
XK9  A1511 ( 4.5A)
None
None
XK9  A1511 (-4.8A)
0.37A 5izjB-2xk9A:
23.6
5izjB-2xk9A:
34.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyu EPHRIN TYPE-A
RECEPTOR 4,


(Mus musculus)
PF07714
(Pkinase_Tyr)
4 GLY A 628
GLY A 630
GLY A 633
VAL A 635
None
None
None
Q9G  A1898 ( 4.7A)
0.33A 5izjB-2xyuA:
17.5
5izjB-2xyuA:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z8c INSULIN RECEPTOR

(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 GLY A1003
GLY A1005
SER A1006
PHE A1007
GLY A1008
S91  A   1 ( 3.9A)
None
None
None
None
0.79A 5izjB-2z8cA:
24.6
5izjB-2z8cA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zv7 TYROSINE-PROTEIN
KINASE LYN


(Mus musculus)
PF07714
(Pkinase_Tyr)
4 GLY A 254
GLY A 256
GLY A 259
VAL A 261
None
0.34A 5izjB-2zv7A:
24.1
5izjB-2zv7A:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cea MYO-INOSITOL
2-DEHYDROGENASE


(Lactobacillus
plantarum)
PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C)
4 GLY A 257
SER A 258
GLY A 260
VAL A 262
None
0.36A 5izjB-3ceaA:
undetectable
5izjB-3ceaA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3coi MITOGEN-ACTIVATED
PROTEIN KINASE 13


(Homo sapiens)
PF00069
(Pkinase)
5 GLY A  32
GLY A  34
GLY A  37
VAL A  39
LEU A  56
None
0.81A 5izjB-3coiA:
22.6
5izjB-3coiA:
27.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dm0 MALTOSE-BINDING
PERIPLASMIC PROTEIN
FUSED WITH RACK1


(Arabidopsis
thaliana;
Escherichia
coli)
PF00400
(WD40)
PF01547
(SBP_bac_1)
5 GLY A1213
SER A1198
GLY A1212
VAL A1217
LEU A1241
None
1.44A 5izjB-3dm0A:
undetectable
5izjB-3dm0A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f3z CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS


(Cryptosporidium
parvum)
PF00069
(Pkinase)
5 GLY A  35
GLY A  37
SER A  38
GLY A  40
VAL A  42
DRK  A   1 ( 3.9A)
None
None
None
DRK  A   1 ( 4.9A)
0.76A 5izjB-3f3zA:
30.0
5izjB-3f3zA:
28.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fhh OUTER MEMBRANE HEME
RECEPTOR SHUA


(Shigella
dysenteriae)
PF00593
(TonB_dep_Rec)
PF07715
(Plug)
4 GLY A 143
GLY A 145
VAL A 636
LEU A 609
None
0.36A 5izjB-3fhhA:
undetectable
5izjB-3fhhA:
19.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3hdn SERINE/THREONINE-PRO
TEIN KINASE SGK1


(Homo sapiens)
PF00069
(Pkinase)
5 GLY A 105
GLY A 107
SER A 108
GLY A 110
LEU A 129
None
GMG  A   1 (-3.3A)
None
None
None
1.16A 5izjB-3hdnA:
28.5
5izjB-3hdnA:
38.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1


(Homo sapiens)
PF07714
(Pkinase_Tyr)
4 GLY A 834
GLY A 836
GLY A 839
VAL A 841
None
None
None
8ST  A2001 ( 4.6A)
0.28A 5izjB-3hngA:
22.2
5izjB-3hngA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3igo CALMODULIN-DOMAIN
PROTEIN KINASE 1


(Cryptosporidium
parvum)
PF00069
(Pkinase)
PF13499
(EF-hand_7)
4 GLY A  83
GLY A  85
SER A  86
GLY A  88
ANP  A 610 (-3.5A)
ANP  A 610 (-2.9A)
ANP  A 610 (-2.6A)
ANP  A 610 (-4.5A)
0.28A 5izjB-3igoA:
23.3
5izjB-3igoA:
25.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3is5 CALCIUM-DEPENDENT
PROTEIN KINASE


(Toxoplasma
gondii)
PF00069
(Pkinase)
5 GLY A 142
GLY A 144
PHE A 146
GLY A 147
VAL A 149
ANP  A   1 (-3.5A)
ANP  A   1 (-3.4A)
None
None
ANP  A   1 (-4.9A)
0.81A 5izjB-3is5A:
19.5
5izjB-3is5A:
25.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kex RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3


(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 GLY A 697
GLY A 699
PHE A 701
GLY A 702
VAL A 704
ANP  A   1 (-3.7A)
ANP  A   1 (-2.8A)
None
None
ANP  A   1 (-3.9A)
0.56A 5izjB-3kexA:
19.4
5izjB-3kexA:
25.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l9y SUPEROXIDE DISMUTASE
[CU-ZN]


(Bombyx mori)
PF00080
(Sod_Cu)
5 GLY A  32
GLY A  15
SER A  14
VAL A  97
LEU A  37
None
1.36A 5izjB-3l9yA:
undetectable
5izjB-3l9yA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lzb EPIDERMAL GROWTH
FACTOR RECEPTOR


(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 GLY A 695
GLY A 697
GLY A 700
VAL A 702
LEU A 723
ITI  A   1 ( 4.8A)
None
None
ITI  A   1 (-4.8A)
None
0.76A 5izjB-3lzbA:
20.1
5izjB-3lzbA:
22.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA


(Homo sapiens)
PF00069
(Pkinase)
5 GLY A  50
GLY A  52
GLY A  55
VAL A  57
LEU A  74
XFE  A 351 ( 4.0A)
None
None
XFE  A 351 ( 4.5A)
None
0.45A 5izjB-3mvjA:
46.1
5izjB-3mvjA:
94.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA


(Homo sapiens)
PF00069
(Pkinase)
5 GLY A  50
GLY A  52
SER A  53
GLY A  55
VAL A  57
XFE  A 351 ( 4.0A)
None
None
None
XFE  A 351 ( 4.5A)
0.54A 5izjB-3mvjA:
46.1
5izjB-3mvjA:
94.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA


(Homo sapiens)
PF00069
(Pkinase)
5 GLY A  50
GLY A  52
SER A  53
PHE A  54
GLY A  55
XFE  A 351 ( 4.0A)
None
None
None
None
1.00A 5izjB-3mvjA:
46.1
5izjB-3mvjA:
94.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3


(Homo sapiens)
PF07714
(Pkinase_Tyr)
4 GLY A 209
GLY A 211
GLY A 214
VAL A 216
None
None
None
LDN  A 600 (-4.5A)
0.33A 5izjB-3my0A:
21.1
5izjB-3my0A:
21.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3o96 RAC-ALPHA
SERINE/THREONINE-PRO
TEIN KINASE


(Homo sapiens)
PF00069
(Pkinase)
PF00169
(PH)
5 GLY A 157
GLY A 159
GLY A 162
VAL A 164
LEU A 181
GLY  A 157 ( 0.0A)
GLY  A 159 ( 0.0A)
GLY  A 162 ( 0.0A)
VAL  A 164 ( 0.6A)
LEU  A 181 ( 0.6A)
0.19A 5izjB-3o96A:
30.4
5izjB-3o96A:
34.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1


(Arabidopsis
thaliana)
PF07714
(Pkinase_Tyr)
6 GLY A 558
GLY A 560
SER A 561
GLY A 563
VAL A 565
LEU A 580
STU  A   1 (-3.2A)
None
None
None
STU  A   1 (-4.9A)
None
0.65A 5izjB-3ppzA:
26.1
5izjB-3ppzA:
26.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3qfv CDC42BPB PROTEIN

(Homo sapiens)
PF00069
(Pkinase)
4 GLY A  83
GLY A  88
VAL A  90
LEU A 107
NM7  A 416 (-3.0A)
None
NM7  A 416 (-3.7A)
EDO  A 417 (-4.6A)
0.33A 5izjB-3qfvA:
30.8
5izjB-3qfvA:
33.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sv0 CASEIN KINASE I-LIKE

(Oryza sativa)
PF00069
(Pkinase)
4 GLY A  16
GLY A  18
SER A  19
GLY A  21
None
0.37A 5izjB-3sv0A:
18.8
5izjB-3sv0A:
22.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3txo PROTEIN KINASE C ETA
TYPE


(Homo sapiens)
PF00069
(Pkinase)
PF00433
(Pkinase_C)
6 GLY A 362
GLY A 364
SER A 365
GLY A 367
VAL A 369
LEU A 386
07U  A   1 ( 4.2A)
None
None
None
07U  A   1 (-4.8A)
None
0.80A 5izjB-3txoA:
31.6
5izjB-3txoA:
39.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3upg OUTER MEMBRANE
PROTEIN C


(Salmonella
enterica)
PF00267
(Porin_1)
5 GLY A  52
GLY A  54
PHE A  40
GLY A  42
LEU A  11
None
0.94A 5izjB-3upgA:
undetectable
5izjB-3upgA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uto TWITCHIN

(Caenorhabditis
elegans)
PF00041
(fn3)
PF00069
(Pkinase)
PF07679
(I-set)
4 GLY A 163
GLY A 165
GLY A 168
VAL A 170
None
0.26A 5izjB-3utoA:
25.7
5izjB-3utoA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2


(Homo sapiens)
PF07714
(Pkinase_Tyr)
4 GLY A 841
GLY A 843
GLY A 846
VAL A 848
4TT  A2001 ( 4.8A)
None
None
4TT  A2001 ( 4.5A)
0.22A 5izjB-3vidA:
21.1
5izjB-3vidA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vte TETRAHYDROCANNABINOL
IC ACID SYNTHASE


(Cannabis sativa)
PF01565
(FAD_binding_4)
PF08031
(BBE)
5 GLY A 183
GLY A 187
PHE A 433
GLY A 188
LEU A 199
FAD  A 607 (-3.1A)
None
None
None
None
1.27A 5izjB-3vteA:
undetectable
5izjB-3vteA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wz2 UNCHARACTERIZED
PROTEIN


(Pyrococcus
furiosus)
PF09754
(PAC2)
5 GLY A 132
SER A 133
GLY A 131
VAL A 173
LEU A 140
None
1.17A 5izjB-3wz2A:
undetectable
5izjB-3wz2A:
22.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3


(Homo sapiens)
PF00069
(Pkinase)
4 GLY A  11
GLY A  13
GLY A  16
VAL A  18
38R  A 350 ( 3.9A)
None
None
38R  A 350 ( 4.8A)
0.33A 5izjB-3zduA:
24.4
5izjB-3zduA:
31.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2


(Homo sapiens)
PF07714
(Pkinase_Tyr)
4 GLY A 841
GLY A 843
GLY A 846
VAL A 848
B49  A2000 ( 4.6A)
None
None
None
0.29A 5izjB-4agdA:
21.0
5izjB-4agdA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4agu CYCLIN-DEPENDENT
KINASE-LIKE 1


(Homo sapiens)
PF00069
(Pkinase)
4 GLY A  11
GLY A  13
GLY A  16
VAL A  18
D15  A 500 (-3.8A)
D15  A 500 (-3.6A)
D15  A 500 (-3.7A)
D15  A 500 (-4.6A)
0.29A 5izjB-4aguA:
25.9
5izjB-4aguA:
24.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA


(Rattus
norvegicus)
PF00069
(Pkinase)
PF00433
(Pkinase_C)
5 GLY A  84
GLY A  86
GLY A  89
VAL A  91
LEU A 108
None
None
None
None
EDO  A1419 (-4.2A)
0.30A 5izjB-4aw2A:
31.7
5izjB-4aw2A:
31.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c02 ACTIVIN RECEPTOR
TYPE-1


(Homo sapiens)
PF00069
(Pkinase)
PF08515
(TGF_beta_GS)
4 GLY A 215
GLY A 217
GLY A 220
VAL A 222
None
None
None
TAK  A1507 (-4.7A)
0.29A 5izjB-4c02A:
21.8
5izjB-4c02A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0t LIKELY PROTEIN
KINASE


(Candida
albicans)
PF00069
(Pkinase)
4 GLY A 247
GLY A 249
VAL A 254
LEU A 271
None
0.30A 5izjB-4c0tA:
30.2
5izjB-4c0tA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d65 PORIN 2

(Providencia
stuartii)
PF00267
(Porin_1)
5 GLY A  53
GLY A  55
PHE A  41
GLY A  43
LEU A  11
None
0.86A 5izjB-4d65A:
undetectable
5izjB-4d65A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e7w GLYCOGEN SYNTHASE
KINASE 3


(Ustilago maydis)
PF00069
(Pkinase)
5 GLY A  45
GLY A  47
SER A  48
GLY A  50
VAL A  52
None
1.09A 5izjB-4e7wA:
24.8
5izjB-4e7wA:
27.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR


(Homo sapiens)
PF07714
(Pkinase_Tyr)
4 GLY A 516
GLY A 518
GLY A 521
VAL A 523
None
0.25A 5izjB-4f0iA:
15.0
5izjB-4f0iA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fr4 SERINE/THREONINE-PRO
TEIN KINASE 32A


(Homo sapiens)
PF00069
(Pkinase)
5 GLY A  30
GLY A  32
SER A  33
GLY A  35
VAL A  37
STU  A 401 (-3.3A)
None
None
None
STU  A 401 ( 4.9A)
0.60A 5izjB-4fr4A:
32.3
5izjB-4fr4A:
29.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3


(Homo sapiens)
PF00069
(Pkinase)
4 GLY A 599
GLY A 601
GLY A 604
VAL A 606
None
None
None
924  A1101 ( 4.8A)
0.34A 5izjB-4g34A:
21.7
5izjB-4g34A:
24.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gv1 RAC-ALPHA
SERINE/THREONINE-PRO
TEIN KINASE


(Homo sapiens)
PF00069
(Pkinase)
PF00433
(Pkinase_C)
5 GLY A 157
GLY A 159
GLY A 162
VAL A 164
LEU A 181
GOL  A 505 ( 3.4A)
0XZ  A 501 (-4.1A)
0XZ  A 501 (-3.8A)
0XZ  A 501 (-4.5A)
GOL  A 503 (-4.9A)
0.29A 5izjB-4gv1A:
37.5
5izjB-4gv1A:
38.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hvi TYROSINE-PROTEIN
KINASE JAK3


(Homo sapiens)
PF07714
(Pkinase_Tyr)
4 GLY A 829
GLY A 831
GLY A 834
VAL A 836
19S  A1201 (-3.7A)
19S  A1201 ( 4.3A)
19S  A1201 ( 4.9A)
19S  A1201 (-4.4A)
0.27A 5izjB-4hviA:
23.6
5izjB-4hviA:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14


(Homo sapiens)
PF00069
(Pkinase)
4 GLY A 407
GLY A 409
SER A 410
GLY A 412
T28  A 701 ( 3.6A)
T28  A 701 ( 3.0A)
None
None
0.31A 5izjB-4idtA:
23.6
5izjB-4idtA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC


(Homo sapiens)
PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr)
5 GLY A 274
GLY A 276
GLY A 279
VAL A 281
LEU A 297
0J9  A 601 ( 4.0A)
None
None
0J9  A 601 (-4.4A)
None
0.57A 5izjB-4k11A:
20.9
5izjB-4k11A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3


(Homo sapiens)
PF07714
(Pkinase_Tyr)
4 GLY A 479
GLY A 481
GLY A 484
VAL A 486
ACP  A 801 (-3.4A)
ACP  A 801 (-3.6A)
ACP  A 801 (-3.6A)
ACP  A 801 (-4.2A)
0.34A 5izjB-4k33A:
18.8
5izjB-4k33A:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ks8 SERINE/THREONINE-PRO
TEIN KINASE PAK 6


(Homo sapiens)
PF00069
(Pkinase)
5 GLY A 414
GLY A 416
SER A 417
GLY A 419
VAL A 421
B49  A 701 ( 4.3A)
None
None
None
None
0.71A 5izjB-4ks8A:
28.1
5izjB-4ks8A:
27.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l9o SEC16,PROTEIN
TRANSPORT PROTEIN
SEC13


(Komagataella
pastoris;
Komagataella
phaffii)
PF00400
(WD40)
4 GLY A1077
SER A1078
GLY A1085
VAL A2013
None
0.32A 5izjB-4l9oA:
undetectable
5izjB-4l9oA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC


(Gallus gallus)
PF07714
(Pkinase_Tyr)
4 GLY A 274
GLY A 276
GLY A 279
VAL A 281
VGG  A 601 ( 3.8A)
None
None
VGG  A 601 ( 3.5A)
0.26A 5izjB-4lggA:
20.1
5izjB-4lggA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1


(Homo sapiens)
PF00069
(Pkinase)
PF00169
(PH)
PF00615
(RGS)
5 GLY A 198
GLY A 200
GLY A 203
VAL A 205
LEU A 222
29X  A 702 ( 4.1A)
29X  A 702 (-3.6A)
29X  A 702 (-3.5A)
29X  A 702 (-4.7A)
None
0.40A 5izjB-4mk0A:
26.8
5izjB-4mk0A:
25.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4otd SERINE/THREONINE-PRO
TEIN KINASE N1


(Homo sapiens)
PF00069
(Pkinase)
PF00433
(Pkinase_C)
5 GLY A 628
GLY A 630
GLY A 633
VAL A 635
LEU A 652
None
0.78A 5izjB-4otdA:
36.5
5izjB-4otdA:
37.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p1e TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT


(Escherichia
fergusonii)
PF03480
(DctP)
5 GLY A 139
SER A 138
PHE A  99
VAL A 243
LEU A  78
IOD  A 404 ( 4.1A)
IOD  A 411 ( 3.1A)
None
None
None
1.41A 5izjB-4p1eA:
undetectable
5izjB-4p1eA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pwn SERINE/THREONINE-PRO
TEIN KINASE WNK1


(Homo sapiens)
PF00069
(Pkinase)
5 GLY A 228
GLY A 230
SER A 231
PHE A 232
LEU A 252
None
0.79A 5izjB-4pwnA:
22.6
5izjB-4pwnA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pwn SERINE/THREONINE-PRO
TEIN KINASE WNK1


(Homo sapiens)
PF00069
(Pkinase)
5 GLY A 228
GLY A 230
SER A 231
VAL A 235
LEU A 252
None
0.36A 5izjB-4pwnA:
22.6
5izjB-4pwnA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q38 PUTATIVE
UNCHARACTERIZED
PROTEIN TCP24


(Actinoplanes
teichomyceticus)
no annotation 5 GLY A 234
SER A 235
GLY A 318
VAL A 320
LEU A 262
TEC  A 404 ( 3.9A)
None
None
None
None
1.28A 5izjB-4q38A:
undetectable
5izjB-4q38A:
20.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4q9z HUMAN PROTEIN KINASE
C THETA


(Homo sapiens)
PF00069
(Pkinase)
PF00433
(Pkinase_C)
5 GLY A 387
GLY A 389
GLY A 392
VAL A 394
LEU A 411
PZW  A 801 ( 3.8A)
None
None
PZW  A 801 (-4.6A)
None
0.77A 5izjB-4q9zA:
35.2
5izjB-4q9zA:
37.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4q9z HUMAN PROTEIN KINASE
C THETA


(Homo sapiens)
PF00069
(Pkinase)
PF00433
(Pkinase_C)
5 GLY A 387
GLY A 389
SER A 390
GLY A 392
LEU A 411
PZW  A 801 ( 3.8A)
None
None
None
None
1.06A 5izjB-4q9zA:
35.2
5izjB-4q9zA:
37.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qny MITOGEN ACTIVATED
PROTEIN KINASE,
PUTATIVE


(Leishmania
donovani)
PF00069
(Pkinase)
4 GLY A  28
GLY A  30
SER A  31
GLY A  33
ANP  A 402 ( 3.7A)
ANP  A 402 (-3.4A)
None
None
0.21A 5izjB-4qnyA:
25.7
5izjB-4qnyA:
25.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qtb MITOGEN-ACTIVATED
PROTEIN KINASE 3


(Homo sapiens)
PF00069
(Pkinase)
4 GLY A  49
GLY A  51
GLY A  54
VAL A  56
None
0.37A 5izjB-4qtbA:
19.1
5izjB-4qtbA:
26.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ra4 PROTEIN KINASE C

(Homo sapiens)
PF00069
(Pkinase)
PF00433
(Pkinase_C)
6 GLY A 346
GLY A 348
SER A 349
GLY A 351
VAL A 353
LEU A 370
3KZ  A 701 (-3.3A)
None
None
None
3KZ  A 701 (-3.9A)
None
0.71A 5izjB-4ra4A:
37.3
5izjB-4ra4A:
36.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1


(Homo sapiens)
PF00069
(Pkinase)
PF16579
(AdenylateSensor)
5 GLY A  25
GLY A  27
PHE A  29
GLY A  30
LEU A  49
STU  A 601 (-3.5A)
STU  A 601 (-3.4A)
None
None
None
1.06A 5izjB-4rewA:
30.8
5izjB-4rewA:
23.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA


(Homo sapiens)
PF00069
(Pkinase)
PF00226
(DnaJ)
5 GLY A 105
GLY A 107
GLY A 110
VAL A 112
LEU A 129
ATP  A 501 (-3.5A)
ATP  A 501 (-3.2A)
ATP  A 501 (-3.8A)
ATP  A 501 (-4.0A)
None
0.62A 5izjB-4wb7A:
45.9
5izjB-4wb7A:
84.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA


(Homo sapiens)
PF00069
(Pkinase)
PF00226
(DnaJ)
5 GLY A 105
GLY A 107
SER A 108
GLY A 110
VAL A 112
ATP  A 501 (-3.5A)
ATP  A 501 (-3.2A)
ATP  A 501 (-3.7A)
ATP  A 501 (-3.8A)
ATP  A 501 (-4.0A)
0.65A 5izjB-4wb7A:
45.9
5izjB-4wb7A:
84.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wbo RHODOPSIN KINASE

(Bos taurus)
PF00069
(Pkinase)
PF00615
(RGS)
5 GLY A 194
GLY A 196
GLY A 199
VAL A 201
LEU A 218
None
0.50A 5izjB-4wboA:
35.6
5izjB-4wboA:
27.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xk8 PUTATIVE
UNCHARACTERIZED
PROTEIN


(Pisum sativum)
PF02605
(PsaL)
5 GLY L  49
GLY L 142
SER L 145
GLY L 143
VAL L  52
None
None
BCR  L 206 (-3.2A)
None
CLA  L 203 (-3.3A)
1.32A 5izjB-4xk8L:
undetectable
5izjB-4xk8L:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3


(Homo sapiens)
PF07714
(Pkinase_Tyr)
4 GLY A 617
GLY A 619
GLY A 622
VAL A 624
None
None
None
P30  A1001 ( 4.8A)
0.17A 5izjB-4xufA:
15.0
5izjB-4xufA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yff SERINE/THREONINE-PRO
TEIN KINASE TNNI3K


(Homo sapiens)
PF07714
(Pkinase_Tyr)
4 GLY A 470
GLY A 472
GLY A 475
VAL A 477
4CV  A 801 ( 3.9A)
None
None
None
0.36A 5izjB-4yffA:
15.3
5izjB-4yffA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yk6 ADENOMATOUS
POLYPOSIS COLI
PROTEIN


(Homo sapiens)
PF00514
(Arm)
PF16629
(Arm_APC_u3)
5 GLY A 618
GLY A 635
SER A 634
GLY A 636
VAL A 617
None
1.44A 5izjB-4yk6A:
undetectable
5izjB-4yk6A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ylj DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 1A


(Homo sapiens)
PF00069
(Pkinase)
5 GLY A 166
GLY A 168
SER A 169
GLY A 171
VAL A 173
4E1  A 505 (-3.5A)
4E1  A 505 ( 4.9A)
None
None
4E1  A 505 (-4.5A)
0.61A 5izjB-4yljA:
24.5
5izjB-4yljA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ahk ACETOLACTATE
SYNTHASE II, LARGE
SUBUNIT


(Pseudomonas
protegens)
PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
5 GLY A 395
GLY A 445
GLY A 448
VAL A 394
LEU A 451
TPP  A 700 (-3.4A)
TPP  A 700 (-3.6A)
TPP  A 700 (-3.7A)
TPP  A 700 (-4.9A)
None
1.42A 5izjB-5ahkA:
undetectable
5izjB-5ahkA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d4o NITROGEN REGULATORY
PROTEIN P-II


(Thiomonas
intermedia)
PF00543
(P-II)
4 GLY A  44
GLY A  46
SER A  47
GLY A  49
ADP  A 201 (-2.8A)
ADP  A 201 (-2.9A)
ADP  A 201 (-2.4A)
ADP  A 201 (-4.3A)
0.31A 5izjB-5d4oA:
undetectable
5izjB-5d4oA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d79 BERBERINE BRIDGE
ENZYME-LIKE PROTEIN


(Arabidopsis
thaliana)
PF01565
(FAD_binding_4)
PF08031
(BBE)
5 GLY A 181
GLY A 185
PHE A 417
GLY A 186
LEU A 197
FAD  A 603 (-3.2A)
None
None
None
None
1.26A 5izjB-5d79A:
undetectable
5izjB-5d79A:
20.30