SIMILAR PATTERNS OF AMINO ACIDS FOR 5IZF_E_AZ1E2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aor ALDEHYDE FERREDOXIN
OXIDOREDUCTASE

(Pyrococcus
furiosus) 		PF01314
(AFOR_C)
PF02730
(AFOR_N) 		4 GLY A 164
GLY A 139
LYS A 391
GLU A 339
 None
 0.72A 5izfA-1aorA:
undetectable		 5izfA-1aorA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aql BILE-SALT ACTIVATED
LIPASE

(Bos taurus) 		PF00135
(COesterase) 		5 GLY A 223
GLY A 221
SER A 220
PHE A 393
LEU A 392
 None
 1.17A 5izfA-1aqlA:
undetectable		 5izfA-1aqlA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bhy P64K

(Neisseria
meningitidis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 GLY A 537
GLY A 539
PHE A 523
LYS A 503
 None
 0.69A 5izfA-1bhyA:
undetectable		 5izfA-1bhyA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ccw PROTEIN (GLUTAMATE
MUTASE)

(Clostridium
cochlearium) 		PF06368
(Met_asp_mut_E) 		4 GLY B 165
GLY B 131
LEU B 157
GLU B  34
 None
 0.87A 5izfA-1ccwB:
undetectable		 5izfA-1ccwB:
22.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1fot CAMP-DEPENDENT
PROTEIN KINASE TYPE
1

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		5 GLY A  94
GLY A  96
SER A  97
PHE A  98
LEU A 118
 None
 1.16A 5izfA-1fotA:
38.8		 5izfA-1fotA:
45.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1fot CAMP-DEPENDENT
PROTEIN KINASE TYPE
1

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		4 GLY A  94
SER A  97
LYS A 116
LEU A 118
 None
 0.80A 5izfA-1fotA:
38.8		 5izfA-1fotA:
45.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fwx NITROUS OXIDE
REDUCTASE

(Paracoccus
denitrificans) 		PF13473
(Cupredoxin_1) 		4 GLY A 271
GLY A 285
SER A 288
LEU A 319
 CL  A4901 ( 3.7A)
None
None
None
 0.68A 5izfA-1fwxA:
undetectable		 5izfA-1fwxA:
20.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gzk RAC-BETA
SERINE/THREONINE
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		4 GLY A 159
GLY A 161
LYS A 181
LEU A 183
 None
 0.37A 5izfA-1gzkA:
30.6		 5izfA-1gzkA:
39.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h0n RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE

(Mus musculus) 		PF00268
(Ribonuc_red_sm) 		4 GLY A 234
PHE A 304
LEU A 305
GLU A 267
 None
None
None
CO  A1354 ( 2.3A)
 0.81A 5izfA-1h0nA:
undetectable		 5izfA-1h0nA:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j3b ATP-DEPENDENT
PHOSPHOENOLPYRUVATE
CARBOXYKINASE

(Thermus
thermophilus) 		PF01293
(PEPCK_ATP) 		4 GLY A 232
GLY A 371
SER A 370
PHE A 390
 None
 0.84A 5izfA-1j3bA:
undetectable		 5izfA-1j3bA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kfu M-CALPAIN LARGE
SUBUNIT

(Homo sapiens) 		PF00648
(Peptidase_C2)
PF01067
(Calpain_III)
PF13833
(EF-hand_8) 		4 GLY L 198
GLY L 203
PHE L 204
LEU L 338
 None
 0.81A 5izfA-1kfuL:
undetectable		 5izfA-1kfuL:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kt8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE,
MITOCHONDRIAL

(Homo sapiens) 		PF01063
(Aminotran_4) 		4 GLY A 312
SER A 311
LEU A 349
GLU A  76
 ILP  A 400 (-3.5A)
None
None
None
 0.79A 5izfA-1kt8A:
undetectable		 5izfA-1kt8A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lm7 SUBDOMAIN OF
DESMOPLAKIN
CARBOXY-TERMINAL
DOMAIN (DPCT)

(Homo sapiens) 		PF00681
(Plectin) 		4 GLY A2319
GLY A2322
PHE A2325
LEU A2292
 None
 0.87A 5izfA-1lm7A:
undetectable		 5izfA-1lm7A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ls9 CYTOCHROME C6

(Cladophora
glomerata) 		PF13442
(Cytochrome_CBB3) 		4 GLY A  61
LYS A  32
LEU A  29
GLU A  44
 HEM  A  92 ( 4.6A)
HEM  A  92 (-3.8A)
HEM  A  92 (-4.9A)
None
 0.83A 5izfA-1ls9A:
undetectable		 5izfA-1ls9A:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m2p CASEIN KINASE II,
ALPHA CHAIN

(Zea mays) 		PF00069
(Pkinase) 		4 GLY A  46
GLY A  48
LYS A  68
LEU A  70
 HNA  A 351 (-2.8A)
HNA  A 351 ( 4.6A)
HNA  A 351 (-2.6A)
None
 0.72A 5izfA-1m2pA:
24.5		 5izfA-1m2pA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nfd N15 ALPHA-BETA
T-CELL RECEPTOR

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set)
PF09291
(DUF1968) 		4 GLY B 109
GLY B   3
SER B   2
GLU A  41
 None
 0.76A 5izfA-1nfdB:
undetectable		 5izfA-1nfdB:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o9i MANGANESE CATALASE

(Lactobacillus
plantarum) 		PF05067
(Mn_catalase) 		4 GLY A 222
GLY A 224
PHE A 228
LEU A 216
 None
 0.86A 5izfA-1o9iA:
undetectable		 5izfA-1o9iA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1olp ALPHA-TOXIN

(Clostridium
sardiniense) 		PF00882
(Zn_dep_PLPC)
PF01477
(PLAT) 		4 GLY A 224
SER A 222
LYS A 230
LEU A 164
 None
 0.87A 5izfA-1olpA:
undetectable		 5izfA-1olpA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oy5 TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE

(Aquifex
aeolicus) 		PF01746
(tRNA_m1G_MT) 		4 GLY A 119
GLY A 115
LEU A  43
GLU A 122
 None
 0.71A 5izfA-1oy5A:
undetectable		 5izfA-1oy5A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p33 PTERIDINE REDUCTASE
1

(Leishmania
tarentolae) 		PF13561
(adh_short_C2) 		4 GLY A  13
GLY A  19
SER A  21
LEU A  26
 NDP  A 300 (-3.6A)
None
None
None
 0.86A 5izfA-1p33A:
undetectable		 5izfA-1p33A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q51 MENB

(Mycobacterium
tuberculosis) 		PF00378
(ECH_1) 		4 GLY A 105
GLY A 161
SER A 164
LEU A 137
 CAA  A 501 (-3.9A)
CAA  A 501 (-3.3A)
None
None
 0.81A 5izfA-1q51A:
undetectable		 5izfA-1q51A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qni NITROUS-OXIDE
REDUCTASE

(Marinobacter
hydrocarbonoclasticus) 		no annotation 4 GLY A 271
GLY A 285
SER A 288
LEU A 319
 CL  A 902 (-3.6A)
None
None
None
 0.72A 5izfA-1qniA:
undetectable		 5izfA-1qniA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tg6 PUTATIVE
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT

(Homo sapiens) 		PF00574
(CLP_protease) 		4 GLY A  33
GLY A  67
SER A  97
LEU A 102
 None
 0.83A 5izfA-1tg6A:
undetectable		 5izfA-1tg6A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1umb 2-OXO ACID
DEHYDROGENASE BETA
SUBUNIT

(Thermus
thermophilus) 		PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 GLY B 122
GLY B 120
SER B 119
GLU B 216
 None
 0.86A 5izfA-1umbB:
undetectable		 5izfA-1umbB:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vbg PYRUVATE,ORTHOPHOSPH
ATE DIKINASE

(Zea mays) 		PF00391
(PEP-utilizers)
PF01326
(PPDK_N)
PF02896
(PEP-utilizers_C) 		5 GLY A  38
GLY A  10
PHE A   9
LEU A  31
GLU A 307
 None
 1.25A 5izfA-1vbgA:
undetectable		 5izfA-1vbgA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xss FLUORESCENT PROTEIN

(Favia favus) 		PF01353
(GFP) 		4 GLY A  27
GLY A  29
SER A  30
LYS A 211
 None
 0.84A 5izfA-1xssA:
undetectable		 5izfA-1xssA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ygg PHOSPHOENOLPYRUVATE
CARBOXYKINASE

(Actinobacillus
succinogenes) 		PF01293
(PEPCK_ATP) 		4 GLY A 248
GLY A 386
SER A 385
PHE A 405
 None
 0.88A 5izfA-1yggA:
undetectable		 5izfA-1yggA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yq2 BETA-GALACTOSIDASE

(Arthrobacter
sp. C2-2) 		PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		4 GLY A 444
GLY A 446
SER A 447
LEU A 417
 None
 0.76A 5izfA-1yq2A:
undetectable		 5izfA-1yq2A:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z3v CELLULASE

(Phanerochaete
chrysosporium) 		PF00840
(Glyco_hydro_7) 		4 GLY A 197
GLY A 199
SER A 200
GLU A  55
 None
 0.59A 5izfA-1z3vA:
undetectable		 5izfA-1z3vA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zrt CYTOCHROME B

(Rhodobacter
capsulatus) 		PF00032
(Cytochrom_B_C)
PF00033
(Cytochrome_B) 		4 GLY C 158
PHE C 166
LEU C 180
GLU C 295
 SMA  C 503 (-3.3A)
SMA  C 503 (-4.2A)
SMA  C 503 (-4.1A)
SMA  C 503 (-3.7A)
 0.85A 5izfA-1zrtC:
undetectable		 5izfA-1zrtC:
20.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1zrz PROTEIN KINASE C,
IOTA

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		4 GLY A 252
GLY A 254
SER A 255
LYS A 274
 BI1  A1000 (-3.6A)
None
None
BI1  A1000 (-3.5A)
 0.75A 5izfA-1zrzA:
30.6		 5izfA-1zrzA:
34.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zyo SERINE PROTEASE

(Sesbania mosaic
virus) 		PF02122
(Peptidase_S39) 		4 GLY A 260
GLY A 262
SER A 263
LEU A 288
 None
 0.84A 5izfA-1zyoA:
undetectable		 5izfA-1zyoA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2abj BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE,
CYTOSOLIC

(Homo sapiens) 		PF01063
(Aminotran_4) 		4 GLY A 330
SER A 329
LEU A 367
GLU A  94
 CBC  A1401 ( 3.4A)
None
None
None
 0.75A 5izfA-2abjA:
undetectable		 5izfA-2abjA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ajz ANTIBODY 7A1 FAB'

(Mus musculus) 		no annotation 4 GLY L  64
GLY L  66
SER L  67
LEU L  27
 None
 0.75A 5izfA-2ajzL:
undetectable		 5izfA-2ajzL:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bcc UBIQUINOL CYTOCHROME
C OXIDOREDUCTASE

(Gallus gallus) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		4 GLY A 340
GLY A 440
SER A 439
LEU A 444
 None
 0.82A 5izfA-2bccA:
undetectable		 5izfA-2bccA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2csn CASEIN KINASE-1

(Schizosaccharomyces
pombe) 		PF00069
(Pkinase) 		5 GLY A  19
GLY A  21
SER A  22
PHE A  23
LYS A  41
 CKI  A 300 ( 3.8A)
None
None
None
None
 1.25A 5izfA-2csnA:
23.6		 5izfA-2csnA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eaa 7S GLOBULIN-3

(Vigna angularis) 		PF00190
(Cupin_1) 		5 GLY A  39
SER A  67
PHE A  65
LEU A  41
GLU A 199
 None
 1.35A 5izfA-2eaaA:
undetectable		 5izfA-2eaaA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fex CONSERVED
HYPOTHETICAL PROTEIN

(Agrobacterium
fabrum) 		PF01965
(DJ-1_PfpI) 		4 GLY A  71
GLY A 155
SER A 156
GLU A  76
 None
 0.85A 5izfA-2fexA:
undetectable		 5izfA-2fexA:
21.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2i0e PROTEIN KINASE
C-BETA II

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		4 GLY A 349
GLY A 351
LYS A 371
LEU A 373
 PDS  A 901 ( 3.7A)
None
PDS  A 901 ( 4.5A)
None
 0.87A 5izfA-2i0eA:
37.2		 5izfA-2i0eA:
36.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ilu ALDEHYDE
DEHYDROGENASE A

(Escherichia
coli) 		PF00171
(Aldedh) 		4 GLY A 253
GLY A 229
LEU A 158
GLU A 289
 None
NDP  A 482 (-3.5A)
None
None
 0.84A 5izfA-2iluA:
undetectable		 5izfA-2iluA:
21.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2jam CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1G

(Homo sapiens) 		PF00069
(Pkinase) 		4 GLY A  30
GLY A  32
PHE A  34
LYS A  52
 None
None
None
EDO  A1304 ( 2.9A)
 0.49A 5izfA-2jamA:
19.6		 5izfA-2jamA:
30.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1v ENDOPLASMIN

(Canis lupus) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		4 GLY A 153
SER A 109
PHE A 277
LEU A 132
 ADP  A 301 ( 4.4A)
None
None
None
 0.88A 5izfA-2o1vA:
undetectable		 5izfA-2o1vA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o2z HYPOTHETICAL PROTEIN

(Bacillus
halodurans) 		PF01933
(UPF0052) 		4 GLY A  43
SER A  89
LEU A  95
GLU A 145
 None
 0.88A 5izfA-2o2zA:
undetectable		 5izfA-2o2zA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pcs CONSERVED PROTEIN

(Geobacillus
kaustophilus) 		PF06240
(COXG) 		4 GLY A   3
GLY A   5
SER A   6
LYS A 130
 None
 0.75A 5izfA-2pcsA:
undetectable		 5izfA-2pcsA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2phk PHOSPHORYLASE KINASE

(Oryctolagus
cuniculus) 		PF00069
(Pkinase) 		4 GLY A  26
GLY A  28
LYS A  48
GLU A 110
 ATP  A 381 (-3.5A)
ATP  A 381 (-3.0A)
ATP  A 381 (-3.2A)
ATP  A 381 (-3.3A)
 0.82A 5izfA-2phkA:
23.7		 5izfA-2phkA:
29.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q27 OXALYL-COA
DECARBOXYLASE

(Escherichia
coli) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 GLY A 428
PHE A  66
LEU A  67
GLU A 445
 None
 0.79A 5izfA-2q27A:
undetectable		 5izfA-2q27A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qj8 MLR6093 PROTEIN

(Mesorhizobium
japonicum) 		PF04952
(AstE_AspA) 		4 GLY A 115
GLY A 111
PHE A 109
LEU A 105
 None
 0.72A 5izfA-2qj8A:
undetectable		 5izfA-2qj8A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qjp CYTOCHROME B

(Rhodobacter
sphaeroides) 		PF00032
(Cytochrom_B_C)
PF00033
(Cytochrome_B) 		4 GLY A 158
PHE A 166
LEU A 180
GLU A 295
 SMA  A   1 (-3.1A)
None
SMA  A   1 ( 4.3A)
SMA  A   1 (-2.9A)
 0.79A 5izfA-2qjpA:
undetectable		 5izfA-2qjpA:
19.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qr7 RIBOSOMAL PROTEIN S6
KINASE ALPHA-3

(Mus musculus) 		PF00069
(Pkinase) 		4 GLY A 429
GLY A 431
SER A 432
LYS A 451
 None
 0.72A 5izfA-2qr7A:
22.7		 5izfA-2qr7A:
31.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r14 MORPHINONE REDUCTASE

(Pseudomonas
putida) 		PF00724
(Oxidored_FMN) 		4 GLY A 300
GLY A  18
SER A  19
LEU A  22
 None
 0.72A 5izfA-2r14A:
undetectable		 5izfA-2r14A:
19.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2v55 RHO-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		4 GLY A  83
GLY A  85
LYS A 105
LEU A 107
 ANP  A1480 ( 4.3A)
ANP  A1480 ( 3.8A)
ANP  A1480 (-3.4A)
None
 0.53A 5izfA-2v55A:
35.0		 5izfA-2v55A:
35.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vz9 FATTY ACID SYNTHASE

(Sus scrofa) 		PF00107
(ADH_zinc_N)
PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF08242
(Methyltransf_12)
PF08659
(KR)
PF14765
(PS-DH)
PF16197
(KAsynt_C_assoc) 		4 GLY A1356
GLY A1398
SER A1395
PHE A1396
 None
 0.82A 5izfA-2vz9A:
undetectable		 5izfA-2vz9A:
8.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wnk SPOROZOITE-SPECIFIC
SAG PROTEIN

(Toxoplasma
gondii) 		PF04092
(SAG) 		4 GLY A 201
GLY A 159
SER A 137
LEU A 143
 None
 0.82A 5izfA-2wnkA:
undetectable		 5izfA-2wnkA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtk SERINE/THREONINE-PRO
TEIN KINASE 11

(Homo sapiens) 		PF00069
(Pkinase) 		4 GLY C  56
GLY C  58
SER C  59
GLU C 138
 ANP  C   2 (-3.3A)
ANP  C   2 (-3.0A)
None
ANP  C   2 (-4.1A)
 0.74A 5izfA-2wtkC:
29.7		 5izfA-2wtkC:
28.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtk SERINE/THREONINE-PRO
TEIN KINASE 11

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLY C  56
GLY C  58
SER C  59
LYS C  78
LEU C  80
 ANP  C   2 (-3.3A)
ANP  C   2 (-3.0A)
None
ANP  C   2 (-3.6A)
None
 1.13A 5izfA-2wtkC:
29.7		 5izfA-2wtkC:
28.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xe5 OUTER MEMBRANE PORIN
C

(Escherichia
coli) 		PF00267
(Porin_1) 		4 GLY A  52
GLY A  54
PHE A  40
LEU A  11
 None
 0.88A 5izfA-2xe5A:
undetectable		 5izfA-2xe5A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xly CLOQ

(Streptomyces
roseochromogenus) 		PF11468
(PTase_Orf2) 		4 GLY A 110
SER A 109
PHE A  68
LEU A  52
 None
 0.82A 5izfA-2xlyA:
undetectable		 5izfA-2xlyA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yiu CYTOCHROME B

(Paracoccus
denitrificans) 		PF00032
(Cytochrom_B_C)
PF00033
(Cytochrome_B) 		4 GLY A 158
PHE A 166
LEU A 180
GLU A 295
 SMA  A 502 (-3.5A)
SMA  A 502 ( 4.7A)
SMA  A 502 ( 4.2A)
SMA  A 502 (-2.5A)
 0.84A 5izfA-2yiuA:
undetectable		 5izfA-2yiuA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z8c INSULIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 GLY A1003
GLY A1005
SER A1006
PHE A1007
 S91  A   1 ( 3.9A)
None
None
None
 0.57A 5izfA-2z8cA:
25.1		 5izfA-2z8cA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zqp PREPROTEIN
TRANSLOCASE SECY
SUBUNIT

(Thermus
thermophilus) 		PF00344
(SecY) 		5 GLY Y  57
GLY Y  53
PHE Y 134
LEU Y 130
GLU Y 195
 None
 1.41A 5izfA-2zqpY:
undetectable		 5izfA-2zqpY:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zuy YESX PROTEIN

(Bacillus
subtilis) 		PF01839
(FG-GAP) 		4 GLY A 403
GLY A 381
LEU A 375
GLU A 344
 None
CA  A 625 (-4.3A)
None
CA  A 628 ( 2.1A)
 0.79A 5izfA-2zuyA:
undetectable		 5izfA-2zuyA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zvi 2,3-DIKETO-5-METHYLT
HIOPENTYL-1-PHOSPHAT
E ENOLASE

(Bacillus
subtilis) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 GLY A 272
PHE A 274
LEU A 287
GLU A 179
 None
 0.85A 5izfA-2zviA:
undetectable		 5izfA-2zviA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a71 EXO-ARABINANASE

(Penicillium
chrysogenum) 		no annotation 4 GLY A 182
GLY A 116
SER A 117
PHE A 118
 None
 0.83A 5izfA-3a71A:
undetectable		 5izfA-3a71A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aeu LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT N

(Rhodobacter
capsulatus) 		PF00148
(Oxidored_nitro) 		5 GLY A 145
GLY A  27
SER A  30
LEU A  55
GLU A 115
 SF4  A 425 (-3.7A)
None
None
None
None
 1.04A 5izfA-3aeuA:
undetectable		 5izfA-3aeuA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3afg SUBTILISIN-LIKE
SERINE PROTEASE

(Thermococcus
kodakarensis) 		PF00082
(Peptidase_S8)
PF04151
(PPC) 		4 GLY A 190
GLY A 205
SER A 139
LEU A 371
 None
 0.70A 5izfA-3afgA:
undetectable		 5izfA-3afgA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bqr DEATH-ASSOCIATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		4 GLY A  20
GLY A  22
LYS A  42
GLU A 100
 4RB  A 401 (-3.6A)
None
4RB  A 401 ( 2.8A)
4RB  A 401 (-3.8A)
 0.52A 5izfA-3bqrA:
20.4		 5izfA-3bqrA:
26.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cdi POLYNUCLEOTIDE
PHOSPHORYLASE

(Escherichia
coli) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C)
PF03726
(PNPase) 		4 GLY A 520
GLY A 486
LEU A 429
GLU A 221
 None
 0.85A 5izfA-3cdiA:
undetectable		 5izfA-3cdiA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cs3 SUGAR-BINDING
TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY

(Enterococcus
faecalis) 		PF13377
(Peripla_BP_3) 		4 GLY A  71
SER A  72
PHE A  73
LEU A  77
 None
None
GOL  A 401 (-4.5A)
None
 0.87A 5izfA-3cs3A:
undetectable		 5izfA-3cs3A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cx5 CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF00355
(Rieske)
PF02921
(UCR_TM) 		4 GLY E 175
GLY E 189
LEU E 137
GLU E 125
 None
 0.86A 5izfA-3cx5E:
undetectable		 5izfA-3cx5E:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dqp OXIDOREDUCTASE YLBE

(Lactococcus
lactis) 		PF13460
(NAD_binding_10) 		4 GLY A   7
GLY A  13
SER A  15
LEU A  20
 None
 0.79A 5izfA-3dqpA:
undetectable		 5izfA-3dqpA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g9k CAPSULE BIOSYNTHESIS
PROTEIN CAPD

(Bacillus
anthracis) 		no annotation 4 GLY S 424
GLY S 426
SER S 427
LEU L 273
 None
 0.79A 5izfA-3g9kS:
undetectable		 5izfA-3g9kS:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gc2 O-SUCCINYLBENZOATE
SYNTHASE

(Salmonella
enterica) 		PF13378
(MR_MLE_C) 		4 GLY A  41
GLY A  43
PHE A  85
LEU A 242
 SIN  A 401 ( 4.7A)
None
None
None
 0.80A 5izfA-3gc2A:
undetectable		 5izfA-3gc2A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gg4 GLYCEROL KINASE

(Yersinia
pseudotuberculosis) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		4 GLY A 449
GLY A 285
SER A 287
GLU A 475
 None
 0.69A 5izfA-3gg4A:
undetectable		 5izfA-3gg4A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gqc DNA REPAIR PROTEIN
REV1

(Homo sapiens) 		PF00817
(IMS)
PF11799
(IMS_C) 		4 GLY A 609
GLY A 611
SER A 612
LEU A 615
 None
 0.71A 5izfA-3gqcA:
undetectable		 5izfA-3gqcA:
20.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3hdn SERINE/THREONINE-PRO
TEIN KINASE SGK1

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLY A 105
GLY A 107
SER A 108
PHE A 109
GLU A 183
 None
GMG  A   1 (-3.3A)
None
None
None
 1.00A 5izfA-3hdnA:
24.6		 5izfA-3hdnA:
38.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A'
DNA-DIRECTED RNA
POLYMERASE SUBUNIT B

(Sulfolobus
solfataricus) 		PF00562
(RNA_pol_Rpb2_6)
PF00623
(RNA_pol_Rpb1_2)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5)
PF04983
(RNA_pol_Rpb1_3)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		4 GLY A 817
SER A 816
LEU A 823
GLU B1032
 None
 0.83A 5izfA-3hkzA:
undetectable		 5izfA-3hkzA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hxk SUGAR HYDROLASE

(Lactococcus
lactis) 		PF00326
(Peptidase_S9) 		4 GLY A 130
GLY A  51
SER A  58
LEU A  65
 None
 0.85A 5izfA-3hxkA:
undetectable		 5izfA-3hxkA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ifr CARBOHYDRATE KINASE,
FGGY

(Rhodospirillum
rubrum) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		4 GLY A 410
GLY A 305
SER A 306
LEU A 379
 None
 0.88A 5izfA-3ifrA:
undetectable		 5izfA-3ifrA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3igo CALMODULIN-DOMAIN
PROTEIN KINASE 1

(Cryptosporidium
parvum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		5 GLY A  83
GLY A  85
SER A  86
PHE A  87
GLU A 159
 ANP  A 610 (-3.5A)
ANP  A 610 (-2.9A)
ANP  A 610 (-2.6A)
ANP  A 610 (-4.7A)
None
 1.12A 5izfA-3igoA:
22.7		 5izfA-3igoA:
25.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3igo CALMODULIN-DOMAIN
PROTEIN KINASE 1

(Cryptosporidium
parvum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		5 GLY A  85
SER A  86
PHE A  87
LEU A 222
GLU A 159
 ANP  A 610 (-2.9A)
ANP  A 610 (-2.6A)
ANP  A 610 (-4.7A)
None
None
 1.29A 5izfA-3igoA:
22.7		 5izfA-3igoA:
25.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3im8 MALONYL ACYL CARRIER
PROTEIN TRANSACYLASE

(Streptococcus
pneumoniae) 		PF00698
(Acyl_transf_1) 		4 GLY A  10
GLY A  12
LEU A  55
GLU A 271
 None
 0.84A 5izfA-3im8A:
undetectable		 5izfA-3im8A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3is5 CALCIUM-DEPENDENT
PROTEIN KINASE

(Toxoplasma
gondii) 		PF00069
(Pkinase) 		4 GLY A 142
GLY A 144
PHE A 146
LYS A 164
 ANP  A   1 (-3.5A)
ANP  A   1 (-3.4A)
None
GOL  A 398 ( 3.1A)
 0.71A 5izfA-3is5A:
19.0		 5izfA-3is5A:
25.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3isa PUTATIVE ENOYL-COA
HYDRATASE/ISOMERASE

(Bordetella
parapertussis) 		PF00378
(ECH_1) 		4 GLY A 114
PHE A  64
LEU A  23
GLU A  89
 None
 0.79A 5izfA-3isaA:
undetectable		 5izfA-3isaA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kd6 CARBOHYDRATE KINASE,
PFKB FAMILY

(Chlorobaculum
tepidum) 		PF00294
(PfkB) 		4 GLY A 242
SER A 270
PHE A 271
LEU A 284
 None
 0.83A 5izfA-3kd6A:
undetectable		 5izfA-3kd6A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kx2 PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43

(Saccharomyces
cerevisiae) 		no annotation 4 GLY B 269
GLY B 116
PHE B 114
LEU B 265
 None
 0.84A 5izfA-3kx2B:
undetectable		 5izfA-3kx2B:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ll9 ISOPENTENYL
PHOSPHATE KINASE

(Methanothermobacter
thermautotrophicus) 		PF00696
(AA_kinase) 		4 GLY A   7
GLY A  48
SER A  49
PHE A  50
 ADP  A 267 (-3.1A)
None
None
None
 0.88A 5izfA-3ll9A:
undetectable		 5izfA-3ll9A:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B

(Homo sapiens) 		PF00069
(Pkinase) 		4 GLY A  40
GLY A  42
LEU A  64
GLU A 117
 None
 0.43A 5izfA-3lm5A:
26.2		 5izfA-3lm5A:
27.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lzb EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 GLY A 695
GLY A 697
LYS A 721
LEU A 723
 ITI  A   1 ( 4.8A)
None
ITI  A   1 (-2.6A)
None
 0.77A 5izfA-3lzbA:
20.4		 5izfA-3lzbA:
22.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLY A  50
GLY A  52
SER A  53
LEU A  74
GLU A 127
 XFE  A 351 ( 4.0A)
None
None
None
XFE  A 351 (-4.2A)
 1.12A 5izfA-3mvjA:
52.2		 5izfA-3mvjA:
94.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLY A  50
GLY A  52
SER A  53
PHE A  54
GLU A 127
 XFE  A 351 ( 4.0A)
None
None
None
XFE  A 351 (-4.2A)
 1.19A 5izfA-3mvjA:
52.2		 5izfA-3mvjA:
94.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLY A  50
SER A  53
LYS A  72
LEU A  74
GLU A 127
 XFE  A 351 ( 4.0A)
None
None
None
XFE  A 351 (-4.2A)
 1.13A 5izfA-3mvjA:
52.2		 5izfA-3mvjA:
94.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3na6 SUCCINYLGLUTAMATE
DESUCCINYLASE/ASPART
OACYLASE

(Ruegeria sp.
TM1040) 		PF04952
(AstE_AspA) 		4 GLY A 119
GLY A 115
PHE A 113
LEU A 109
 None
 0.78A 5izfA-3na6A:
undetectable		 5izfA-3na6A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3njr PRECORRIN-6Y
METHYLASE

(Rhodobacter
capsulatus) 		no annotation 4 GLY A 108
GLY A 111
SER A 112
LEU A 119
 SAH  A 300 ( 4.8A)
None
None
None
 0.70A 5izfA-3njrA:
undetectable		 5izfA-3njrA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3njr PRECORRIN-6Y
METHYLASE

(Rhodobacter
capsulatus) 		no annotation 4 GLY A 111
SER A 112
LEU A 119
GLU A  63
 None
None
None
SAH  A 300 (-2.6A)
 0.78A 5izfA-3njrA:
undetectable		 5izfA-3njrA:
19.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3nuu PKB-LIKE

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLY A  89
GLY A  91
SER A  92
LEU A 113
GLU A 166
 JOZ  A 361 ( 4.3A)
SO4  A   5 ( 4.4A)
SO4  A   5 (-4.4A)
None
None
 1.34A 5izfA-3nuuA:
28.9		 5izfA-3nuuA:
37.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3nuu PKB-LIKE

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLY A  89
SER A  92
LYS A 111
LEU A 113
GLU A 166
 JOZ  A 361 ( 4.3A)
SO4  A   5 (-4.4A)
SO4  A   5 (-2.8A)
None
None
 1.30A 5izfA-3nuuA:
28.9		 5izfA-3nuuA:
37.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3o96 RAC-ALPHA
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase)
PF00169
(PH) 		4 GLY A 157
GLY A 159
LYS A 179
LEU A 181
 GLY  A 157 ( 0.0A)
GLY  A 159 ( 0.0A)
LYS  A 179 ( 0.0A)
LEU  A 181 ( 0.6A)
 0.18A 5izfA-3o96A:
29.3		 5izfA-3o96A:
34.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ob8 BETA-GALACTOSIDASE

(Kluyveromyces
lactis) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N) 		4 GLY A 933
SER A 918
LEU A 941
GLU A 967
 None
 0.79A 5izfA-3ob8A:
undetectable		 5izfA-3ob8A:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		4 GLY A 558
GLY A 560
LYS A 578
LEU A 580
 STU  A   1 (-3.2A)
None
STU  A   1 (-3.5A)
None
 0.74A 5izfA-3ppzA:
25.8		 5izfA-3ppzA:
26.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		4 GLY A 558
GLY A 560
SER A 561
LEU A 580
 STU  A   1 (-3.2A)
None
None
None
 0.48A 5izfA-3ppzA:
25.8		 5izfA-3ppzA:
26.70