SIMILAR PATTERNS OF AMINO ACIDS FOR 5IWU_A_ERYA404_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f1u HOMOPROTOCATECHUATE
2,3-DIOXYGENASE

(Arthrobacter
globiformis) 		PF00903
(Glyoxalase) 		4 GLY A 249
ASP A 154
ILE A 268
TYR A 257
 None
 1.02A 5iwuA-1f1uA:
undetectable		 5iwuA-1f1uA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f1x HOMOPROTOCATECHUATE
2,3-DIOXYGENASE

(Brevibacterium
fuscum) 		PF00903
(Glyoxalase) 		4 GLY A 249
ASP A 154
ILE A 268
TYR A 257
 None
None
None
FEL  A 500 (-4.7A)
 0.86A 5iwuA-1f1xA:
undetectable		 5iwuA-1f1xA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fta FRUCTOSE-1,6-BISPHOS
PHATASE

(Homo sapiens) 		PF00316
(FBPase) 		4 GLY A 273
ASP A 251
ILE A 261
TYR A 215
 None
 1.08A 5iwuA-1ftaA:
0.6		 5iwuA-1ftaA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hr7 MITOCHONDRIAL
PROCESSING PEPTIDASE
BETA SUBUNIT

(Saccharomyces
cerevisiae) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		4 GLY B  57
ASP B 164
ARG B 178
TYR B 330
 None
 1.07A 5iwuA-1hr7B:
0.0		 5iwuA-1hr7B:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kfi PHOSPHOGLUCOMUTASE 1

(Paramecium
tetraurelia) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		4 GLY A 115
ASP A 208
ILE A 402
ARG A 108
 None
 0.99A 5iwuA-1kfiA:
undetectable		 5iwuA-1kfiA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kp2 ARGININOSUCCINATE
SYNTHETASE

(Escherichia
coli) 		PF00764
(Arginosuc_synth) 		4 GLY A 327
ASP A 135
ILE A 283
TYR A  98
 None
ATP  A 459 (-3.5A)
None
PO4  A 456 (-4.5A)
 1.13A 5iwuA-1kp2A:
0.0		 5iwuA-1kp2A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1luf MUSCLE-SPECIFIC
TYROSINE KINASE
RECEPTOR MUSK

(Rattus
norvegicus) 		PF07714
(Pkinase_Tyr) 		4 GLY A 798
ASP A 724
ILE A 765
ARG A 766
 None
 1.04A 5iwuA-1lufA:
6.8		 5iwuA-1lufA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mt0 HEMOLYSIN SECRETION
ATP-BINDING PROTEIN

(Escherichia
coli) 		PF00005
(ABC_tran) 		4 GLY A 679
ASP A 630
ILE A 515
TYR A 477
 None
 1.01A 5iwuA-1mt0A:
0.0		 5iwuA-1mt0A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rpw TRANSCRIPTIONAL
REGULATOR QACR

(Staphylococcus
aureus) 		PF00440
(TetR_N)
PF08360
(TetR_C_5) 		4 GLY A 158
ILE A 130
TYR A  82
TYR A  92
 None
 1.08A 5iwuA-1rpwA:
undetectable		 5iwuA-1rpwA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ue8 367AA LONG
HYPOTHETICAL
CYTOCHROME P450

(Sulfurisphaera
tokodaii) 		PF00067
(p450) 		4 ASP A 225
ILE A 299
ARG A 302
TYR A   2
 None
 1.14A 5iwuA-1ue8A:
0.0		 5iwuA-1ue8A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ven BETA-AMYLASE

(Bacillus cereus) 		PF00686
(CBM_20)
PF01373
(Glyco_hydro_14) 		4 GLY A 168
ILE A 353
TYR A 310
TYR A 178
 None
None
None
GLC  A 903 (-4.5A)
 0.98A 5iwuA-1venA:
undetectable		 5iwuA-1venA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ven BETA-AMYLASE

(Bacillus cereus) 		PF00686
(CBM_20)
PF01373
(Glyco_hydro_14) 		4 GLY A 171
ILE A 353
TYR A 310
TYR A 178
 GLC  A 900 ( 4.9A)
None
None
GLC  A 903 (-4.5A)
 0.97A 5iwuA-1venA:
undetectable		 5iwuA-1venA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w5d PENICILLIN-BINDING
PROTEIN

(Bacillus
subtilis) 		PF02113
(Peptidase_S13) 		4 GLY A 219
ASP A 129
ILE A 154
TYR A 194
 None
 1.12A 5iwuA-1w5dA:
undetectable		 5iwuA-1w5dA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xyz 1,4-BETA-D-XYLAN-XYL
ANOHYDROLASE

(Ruminiclostridium
thermocellum) 		PF00331
(Glyco_hydro_10) 		4 GLY A 653
ILE A 658
TYR A 667
TYR A 686
 None
 1.04A 5iwuA-1xyzA:
undetectable		 5iwuA-1xyzA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z6c VITAMIN K-DEPENDENT
PROTEIN S

(Homo sapiens) 		PF07645
(EGF_CA) 		4 GLY A 221
ASP A 182
ILE A 170
ARG A 192
 None
 1.09A 5iwuA-1z6cA:
undetectable		 5iwuA-1z6cA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c4n PROTEIN NAGD

(Escherichia
coli) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		4 GLY A 151
ASP A 201
ILE A  10
TYR A  44
 None
MG  A1251 (-2.6A)
PO4  A1253 ( 4.2A)
PO4  A1253 (-4.2A)
 1.10A 5iwuA-2c4nA:
undetectable		 5iwuA-2c4nA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ghs AGR_C_1268P

(Agrobacterium
fabrum) 		PF08450
(SGL) 		4 GLY A 121
ASP A 165
ILE A 151
TYR A 152
 None
 1.11A 5iwuA-2ghsA:
1.6		 5iwuA-2ghsA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gk1 BETA-HEXOSAMINIDASE
SUBUNIT ALPHA
BETA-HEXOSAMINIDASE
SUBUNIT BETA CHAIN A

(Homo sapiens;
Homo sapiens) 		no annotation
no annotation 		4 ASP I 175
ARG I 424
TYR N 456
TYR N 547
 None
 1.13A 5iwuA-2gk1I:
undetectable		 5iwuA-2gk1I:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h34 SERINE/THREONINE-PRO
TEIN KINASE PKNE

(Mycobacterium
tuberculosis) 		PF00069
(Pkinase) 		4 ILE A 198
ARG A 260
TYR A 199
TYR A 215
 None
 1.13A 5iwuA-2h34A:
6.1		 5iwuA-2h34A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2olw RIBOSOMAL LARGE
SUBUNIT
PSEUDOURIDINE
SYNTHASE E

(Escherichia
coli) 		PF00849
(PseudoU_synth_2) 		4 GLY A  76
ASP A  81
ILE A 195
TYR A 109
 None
 1.14A 5iwuA-2olwA:
undetectable		 5iwuA-2olwA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oml RIBOSOMAL LARGE
SUBUNIT
PSEUDOURIDINE
SYNTHASE E

(Escherichia
coli) 		PF00849
(PseudoU_synth_2) 		4 GLY A  76
ASP A  81
ILE A 195
TYR A 109
 None
SO4  A1428 ( 4.9A)
None
SO4  A1424 (-4.3A)
 1.08A 5iwuA-2omlA:
undetectable		 5iwuA-2omlA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q66 POLY(A) POLYMERASE

(Saccharomyces
cerevisiae) 		PF01909
(NTP_transf_2)
PF04926
(PAP_RNA-bind)
PF04928
(PAP_central) 		4 GLY A  88
ILE A 209
ARG A 212
TYR A 224
 ATP  A 605 (-3.2A)
None
None
ATP  A 605 (-4.5A)
 1.02A 5iwuA-2q66A:
undetectable		 5iwuA-2q66A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q6t DNAB REPLICATION
FORK HELICASE

(Thermus
aquaticus) 		PF00772
(DnaB)
PF03796
(DnaB_C) 		4 ASP A 378
ILE A 414
ARG A 373
TYR A 396
 None
 1.08A 5iwuA-2q6tA:
undetectable		 5iwuA-2q6tA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qob EPHRIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 GLY A 821
ASP A 746
ILE A 788
ARG A 789
 None
 1.10A 5iwuA-2qobA:
7.9		 5iwuA-2qobA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qzu PUTATIVE SULFATASE
YIDJ

(Bacteroides
fragilis) 		PF00884
(Sulfatase) 		4 GLY A  44
ILE A 316
ARG A  39
TYR A 246
 None
 0.88A 5iwuA-2qzuA:
undetectable		 5iwuA-2qzuA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rhq PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN

(Staphylococcus
haemolyticus;
Staphylococcus
haemolyticus) 		PF01409
(tRNA-synt_2d)
PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5) 		4 GLY B 582
ASP A 317
ILE A 215
TYR A 199
 None
 1.02A 5iwuA-2rhqB:
undetectable		 5iwuA-2rhqB:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vsq SURFACTIN SYNTHETASE
SUBUNIT 3

(Bacillus
subtilis) 		PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00668
(Condensation)
PF00975
(Thioesterase)
PF13193
(AMP-binding_C) 		4 GLY A 634
ASP A 664
ILE A 531
TYR A 611
 None
 1.12A 5iwuA-2vsqA:
undetectable		 5iwuA-2vsqA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xts SULFITE
DEHYDROGENASE

(Paracoccus
pantotrophus) 		PF00174
(Oxidored_molyb)
PF03404
(Mo-co_dimer) 		4 GLY A 164
ASP A 396
ILE A 401
ARG A 402
 None
GOL  A1432 (-3.5A)
None
None
 1.07A 5iwuA-2xtsA:
undetectable		 5iwuA-2xtsA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xts SULFITE
DEHYDROGENASE

(Paracoccus
pantotrophus) 		PF00174
(Oxidored_molyb)
PF03404
(Mo-co_dimer) 		4 GLY A 165
ASP A 396
ILE A 401
ARG A 402
 None
GOL  A1432 (-3.5A)
None
None
 1.04A 5iwuA-2xtsA:
undetectable		 5iwuA-2xtsA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yr0 HYPOTHETICAL PROTEIN
TTHA0223

(Thermus
thermophilus) 		PF08241
(Methyltransf_11) 		4 GLY A 140
ASP A  68
ILE A  65
TYR A  64
 None
 1.14A 5iwuA-2yr0A:
undetectable		 5iwuA-2yr0A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aq1 THERMOSOME SUBUNIT

(Methanococcoides
burtonii) 		PF00118
(Cpn60_TCP1) 		4 GLY B 152
ASP B  83
ILE B 484
TYR B 471
 None
 1.11A 5iwuA-3aq1B:
undetectable		 5iwuA-3aq1B:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayf NITRIC OXIDE
REDUCTASE

(Geobacillus
stearothermophilus) 		PF00115
(COX1) 		4 GLY A 652
ASP A 500
ILE A 431
TYR A  93
 HEM  A 802 ( 3.9A)
None
None
HEM  A 801 ( 3.9A)
 1.11A 5iwuA-3ayfA:
undetectable		 5iwuA-3ayfA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bgw DNAB-LIKE
REPLICATIVE HELICASE

(Bacillus phage
SPP1) 		PF00772
(DnaB)
PF03796
(DnaB_C) 		4 ASP A 373
ILE A 409
ARG A 368
TYR A 391
 None
 1.05A 5iwuA-3bgwA:
undetectable		 5iwuA-3bgwA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bh0 DNAB-LIKE
REPLICATIVE HELICASE

(Bacillus phage
SPP1) 		PF03796
(DnaB_C) 		4 ASP A 373
ILE A 409
ARG A 368
TYR A 391
 None
 1.02A 5iwuA-3bh0A:
undetectable		 5iwuA-3bh0A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bv4 FRUCTOSE-BISPHOSPHAT
E ALDOLASE A

(Oryctolagus
cuniculus) 		PF00274
(Glycolytic) 		4 GLY A 273
ASP A  33
ILE A  39
ARG A  42
 None
None
None
SO4  A   1 (-3.2A)
 1.03A 5iwuA-3bv4A:
undetectable		 5iwuA-3bv4A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bwm CATECHOL
O-METHYLTRANSFERASE

(Homo sapiens) 		PF01596
(Methyltransf_3) 		4 GLY A  66
ASP A 205
ILE A  49
TYR A 147
 SAM  A 301 (-3.2A)
None
None
None
 1.07A 5iwuA-3bwmA:
undetectable		 5iwuA-3bwmA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dcd GALACTOSE MUTAROTASE
RELATED ENZYME

(Lactobacillus
acidophilus) 		PF01263
(Aldose_epim) 		4 GLY A 145
ASP A   2
ILE A   5
TYR A 115
 None
 0.83A 5iwuA-3dcdA:
undetectable		 5iwuA-3dcdA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwk PENICILLIN-BINDING
PROTEIN 2

(Staphylococcus
aureus) 		PF00905
(Transpeptidase)
PF00912
(Transgly) 		4 ASP A 241
ARG A 283
TYR A 210
TYR A 196
 None
SO4  A  22 (-2.9A)
None
None
 1.08A 5iwuA-3dwkA:
undetectable		 5iwuA-3dwkA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eck PROTEIN
(HOMOPROTOCATECHUATE
2,3-DIOXYGENASE)

(Brevibacterium
fuscum) 		PF00903
(Glyoxalase) 		4 GLY A 249
ASP A 154
ILE A 268
TYR A 257
 None
 1.09A 5iwuA-3eckA:
undetectable		 5iwuA-3eckA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ecq ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE

(Streptococcus
pneumoniae) 		PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C) 		4 GLY A 619
ASP A 764
ILE A 693
TYR A 701
 None
 1.02A 5iwuA-3ecqA:
undetectable		 5iwuA-3ecqA:
11.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f8r THIOREDOXIN
REDUCTASE (TRXB-3)

(Sulfolobus
solfataricus) 		PF07992
(Pyr_redox_2) 		4 GLY A  50
ASP A 148
ILE A 245
ARG A 125
 NAP  A4005 (-3.5A)
None
None
None
 0.89A 5iwuA-3f8rA:
undetectable		 5iwuA-3f8rA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fii BOTULINUM NEUROTOXIN
TYPE F
FRAGMENT OF
VESICLE-ASSOCIATED
MEMBRANE PROTEIN 2

(Clostridium
botulinum;
Homo sapiens) 		PF01742
(Peptidase_M27)
PF00957
(Synaptobrevin) 		4 GLY A 186
ASP B  57
ILE A 230
TYR A 349
 None
 0.82A 5iwuA-3fiiA:
undetectable		 5iwuA-3fiiA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gr8 NADPH DEHYDROGENASE

(Geobacillus
kaustophilus) 		PF00724
(Oxidored_FMN) 		4 GLY A 187
ASP A 220
ILE A 216
TYR A 234
 None
 1.04A 5iwuA-3gr8A:
undetectable		 5iwuA-3gr8A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ip3 OXIDOREDUCTASE,
PUTATIVE

(Thermotoga
maritima) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 GLY A  11
ASP A 248
ILE A 234
TYR A 236
 None
 0.90A 5iwuA-3ip3A:
undetectable		 5iwuA-3ip3A:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qbo PHOSPHOSERINE
AMINOTRANSFERASE

(Yersinia pestis) 		PF00266
(Aminotran_5) 		4 ASP A 160
ILE A 291
ARG A 294
TYR A 276
 None
 1.02A 5iwuA-3qboA:
undetectable		 5iwuA-3qboA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r1i SHORT-CHAIN TYPE
DEHYDROGENASE/REDUCT
ASE

(Mycobacterium
marinum) 		PF13561
(adh_short_C2) 		4 GLY A  97
ASP A 245
ILE A 248
TYR A 230
 None
 1.00A 5iwuA-3r1iA:
undetectable		 5iwuA-3r1iA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s29 SUCROSE SYNTHASE 1

(Arabidopsis
thaliana) 		PF00534
(Glycos_transf_1)
PF00862
(Sucrose_synth) 		4 GLY A  95
ASP A 138
ILE A 469
TYR A  99
 None
 1.13A 5iwuA-3s29A:
undetectable		 5iwuA-3s29A:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tl2 MALATE DEHYDROGENASE

(Bacillus
anthracis) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 GLY A 223
ASP A 153
ILE A 210
ARG A 213
 None
 1.13A 5iwuA-3tl2A:
undetectable		 5iwuA-3tl2A:
26.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v5q NT-3 GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 GLY A 767
ASP A 679
ILE A 734
ARG A 735
 None
 0.89A 5iwuA-3v5qA:
6.0		 5iwuA-3v5qA:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vsz RICIN B LECTIN

(Ruminiclostridium
thermocellum) 		PF04616
(Glyco_hydro_43)
PF14200
(RicinB_lectin_2) 		4 GLY A 175
ILE A 157
ARG A 158
TYR A 206
 None
 1.05A 5iwuA-3vszA:
undetectable		 5iwuA-3vszA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zzw TYROSINE-PROTEIN
KINASE TRANSMEMBRANE
RECEPTOR ROR2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 GLY A 689
ASP A 615
ILE A 656
ARG A 657
 None
 0.99A 5iwuA-3zzwA:
6.4		 5iwuA-3zzwA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a1f REPLICATIVE DNA
HELICASE

(Helicobacter
pylori) 		PF03796
(DnaB_C) 		4 ASP A 371
ILE A 441
ARG A 366
TYR A 389
 None
 1.04A 5iwuA-4a1fA:
undetectable		 5iwuA-4a1fA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4arx PESTICIDAL CRYSTAL
PROTEIN CRY1AC

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		4 GLY A 425
ASP A  62
ILE A  38
TYR A  33
 None
 1.10A 5iwuA-4arxA:
undetectable		 5iwuA-4arxA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 GLY A 766
ASP A 692
ILE A 733
ARG A 734
 None
 0.94A 5iwuA-4at3A:
6.2		 5iwuA-4at3A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4au0 EXOGLUCANASE 2

(Trichoderma
reesei) 		PF01341
(Glyco_hydro_6) 		4 GLY A 183
ASP A 263
ILE A 246
TYR A 242
 None
 1.11A 5iwuA-4au0A:
undetectable		 5iwuA-4au0A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aw5 EPHRIN TYPE-B
RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 GLY A 293
ASP A 216
ILE A 260
ARG A 261
 None
 1.10A 5iwuA-4aw5A:
7.0		 5iwuA-4aw5A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4awe ENDO-BETA-D-1,4-MANN
ANASE

(Neurospora
sitophila) 		PF00150
(Cellulase) 		4 GLY A  78
ILE A 363
TYR A 364
TYR A 353
 CL  A1394 ( 3.9A)
None
None
None
 1.03A 5iwuA-4aweA:
undetectable		 5iwuA-4aweA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cak INTEGRIN ALPHA-IIB
INTEGRIN BETA-3

(Homo sapiens;
Homo sapiens) 		PF01839
(FG-GAP)
PF08441
(Integrin_alpha2)
PF00362
(Integrin_beta)
PF07965
(Integrin_B_tail)
PF07974
(EGF_2)
PF17205
(PSI_integrin) 		4 GLY A 309
ASP B 288
ILE B 226
TYR B 321
 None
 1.13A 5iwuA-4cakA:
undetectable		 5iwuA-4cakA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e3e MAOC DOMAIN PROTEIN
DEHYDRATASE

(Chloroflexus
aurantiacus) 		PF01575
(MaoC_dehydratas) 		4 GLY A 265
ASP A  65
ILE A 255
TYR A 345
 None
 0.81A 5iwuA-4e3eA:
undetectable		 5iwuA-4e3eA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 GLY A 723
ASP A 649
ILE A 690
ARG A 691
 None
 0.90A 5iwuA-4f0iA:
4.2		 5iwuA-4f0iA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fz4 UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA

(Streptococcus
suis) 		PF16828
(GAGBD) 		4 GLY A  80
ILE A 152
ARG A 143
TYR A 156
 None
 1.13A 5iwuA-4fz4A:
undetectable		 5iwuA-4fz4A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4glf RSFP

(uncultured
bacterium) 		PF01048
(PNP_UDP_1) 		4 GLY A  20
ILE A 174
TYR A 171
TYR A 214
 None
 1.07A 5iwuA-4glfA:
undetectable		 5iwuA-4glfA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gvr METHENYLTETRAHYDROME
THANOPTERIN
CYCLOHYDROLASE

(Archaeoglobus
fulgidus) 		PF02289
(MCH) 		4 GLY A 108
ASP A  37
ILE A  34
TYR A 104
 None
 1.05A 5iwuA-4gvrA:
undetectable		 5iwuA-4gvrA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gzu FERM, RHOGEF AND
PLECKSTRIN
DOMAIN-CONTAINING
PROTEIN 2

(Mus musculus) 		PF00169
(PH)
PF00621
(RhoGEF) 		4 GLY A 617
ASP A 537
ILE A 542
TYR A 702
 None
 1.00A 5iwuA-4gzuA:
undetectable		 5iwuA-4gzuA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i5u CHIMERIC CEL6A

(Humicola
insolens;
Trichoderma
reesei;
Chaetomium
thermophilum) 		PF01341
(Glyco_hydro_6) 		4 GLY A 184
ASP A 264
ILE A 247
TYR A 243
 EDO  A 507 (-3.3A)
None
None
None
 1.09A 5iwuA-4i5uA:
undetectable		 5iwuA-4i5uA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpn NUCLEOSIDE
N-RIBOHYDROLASE 1

(Physcomitrella
patens) 		PF01156
(IU_nuc_hydro) 		4 GLY A 175
ASP A 258
ILE A 254
TYR A 244
 None
CA  A 400 (-2.8A)
None
None
 1.02A 5iwuA-4kpnA:
undetectable		 5iwuA-4kpnA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o0l NADPH-DEPENDENT
3-QUINUCLIDINONE
REDUCTASE

(Rhodotorula
mucilaginosa) 		PF13561
(adh_short_C2) 		4 GLY A 115
ASP A 262
ILE A 265
TYR A 247
 NDP  A 300 (-3.5A)
None
None
None
 0.97A 5iwuA-4o0lA:
undetectable		 5iwuA-4o0lA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p2k EPHRIN TYPE-A
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		4 GLY A 814
ASP A 739
ILE A 781
ARG A 782
 None
 1.04A 5iwuA-4p2kA:
7.8		 5iwuA-4p2kA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q1z PUTATIVE LIPOPROTEIN

(Bacteroides
thetaiotaomicron) 		PF16215
(DUF4876) 		4 GLY A 380
ASP A 329
ILE A 108
TYR A 114
 None
 1.07A 5iwuA-4q1zA:
2.3		 5iwuA-4q1zA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wfn 50S RIBOSOMAL
PROTEIN L19

(Deinococcus
radiodurans) 		PF01245
(Ribosomal_L19) 		4 GLY M  74
ASP M  31
ILE M  55
ARG M  69
 None
 1.11A 5iwuA-4wfnM:
undetectable		 5iwuA-4wfnM:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4whm UDP-GLUCOSE:ANTHOCYA
NIDIN
3-O-GLUCOSYLTRANSFER
ASE

(Clitoria
ternatea) 		PF00201
(UDPGT) 		4 GLY A 369
ASP A 184
ILE A 148
TYR A 145
 GOL  A1003 (-3.7A)
None
None
None
 1.14A 5iwuA-4whmA:
undetectable		 5iwuA-4whmA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4woq N-ACETYLNEURAMINATE
LYASE

(Clostridioides
difficile) 		PF00701
(DHDPS) 		4 GLY A  56
ASP A 201
ILE A  18
TYR A 147
 None
 1.09A 5iwuA-4woqA:
undetectable		 5iwuA-4woqA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ynu GLUCOSE OXIDASE,
PUTATIVE

(Aspergillus
flavus) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		4 GLY A  88
ASP A 315
ILE A 425
TYR A  65
 FAD  A 601 (-3.0A)
None
None
None
 1.14A 5iwuA-4ynuA:
undetectable		 5iwuA-4ynuA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ypv EST8

(Parvibaculum) 		PF07859
(Abhydrolase_3) 		4 GLY A  88
ASP A  42
TYR A  83
TYR A 187
 None
 1.12A 5iwuA-4ypvA:
undetectable		 5iwuA-4ypvA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zc0 REPLICATIVE DNA
HELICASE

(Helicobacter
pylori) 		PF00772
(DnaB)
PF03796
(DnaB_C) 		4 ASP A 371
ILE A 441
ARG A 366
TYR A 389
 None
 1.07A 5iwuA-4zc0A:
undetectable		 5iwuA-4zc0A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a55 ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE

(Streptococcus
pneumoniae) 		PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C) 		4 GLY A 619
ASP A 764
ILE A 693
TYR A 701
 None
 0.96A 5iwuA-5a55A:
undetectable		 5iwuA-5a55A:
14.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c1b TRANSITIONAL
ENDOPLASMIC
RETICULUM ATPASE

(Homo sapiens) 		PF00004
(AAA)
PF02359
(CDC48_N)
PF02933
(CDC48_2)
PF09336
(Vps4_C) 		4 GLY A  97
ASP A 204
ILE A  32
ARG A  83
 None
 1.13A 5iwuA-5c1bA:
undetectable		 5iwuA-5c1bA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5czj DIHYDRODIPICOLINATE
SYNTHASE

(Sinorhizobium
meliloti) 		PF00701
(DHDPS) 		4 GLY A  97
ASP A 275
ILE A 210
TYR A 161
 None
 1.11A 5iwuA-5czjA:
undetectable		 5iwuA-5czjA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5efn HDAC6 PROTEIN

(Danio rerio) 		no annotation 4 GLY B 714
ASP B 610
ILE B 666
TYR B 678
 None
K  B 802 (-3.1A)
None
None
 1.14A 5iwuA-5efnB:
undetectable		 5iwuA-5efnB:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eyf GLUTAMATE ABC
SUPERFAMILY ATP
BINDING CASSETTE
TRANSPORTER, BINDING
PROTEIN

(Enterococcus
faecium) 		PF00497
(SBP_bac_3) 		4 GLY A  55
ILE A  97
ARG A  96
TYR A 128
 None
None
GGL  A 301 (-3.1A)
None
 1.07A 5iwuA-5eyfA:
undetectable		 5iwuA-5eyfA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g0h HDAC6

(Danio rerio) 		PF00850
(Hist_deacetyl) 		4 GLY A 714
ASP A 610
ILE A 666
TYR A 678
 None
K  A1802 (-3.2A)
None
None
 1.13A 5iwuA-5g0hA:
undetectable		 5iwuA-5g0hA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gjw VOLTAGE-DEPENDENT
CALCIUM CHANNEL
SUBUNIT
ALPHA-2/DELTA-1

(Oryctolagus
cuniculus) 		PF00092
(VWA)
PF08399
(VWA_N)
PF08473
(VGCC_alpha2) 		4 ASP F 764
ARG F 769
TYR F 601
TYR F 782
 None
 1.13A 5iwuA-5gjwF:
undetectable		 5iwuA-5gjwF:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h2t TREHALOSE SYNTHASE

(Thermomonospora
curvata) 		no annotation 4 GLY A  35
ASP A  55
ILE A 110
TYR A  29
 None
 1.10A 5iwuA-5h2tA:
3.0		 5iwuA-5h2tA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5htk 6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
SPHOSPHATASE 2

(Homo sapiens) 		PF00300
(His_Phos_1)
PF01591
(6PF2K) 		4 GLY A  75
ASP A 189
ILE A 194
TYR A 197
 FLC  A 601 (-3.0A)
None
None
GOL  A 606 ( 3.4A)
 0.84A 5iwuA-5htkA:
undetectable		 5iwuA-5htkA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6z SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER

(Homo sapiens) 		PF00209
(SNF) 		4 GLY A 129
ASP A  98
ILE A  93
TYR A 121
 None
 0.98A 5iwuA-5i6zA:
undetectable		 5iwuA-5i6zA:
21.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5igu MACROLIDE
2'-PHOSPHOTRANSFERAS
E II

(Escherichia
coli) 		PF01636
(APH) 		4 ASP A 200
ILE A 233
ARG A 237
TYR A 273
 None
 0.42A 5iwuA-5iguA:
31.5		 5iwuA-5iguA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5igu MACROLIDE
2'-PHOSPHOTRANSFERAS
E II

(Escherichia
coli) 		PF01636
(APH) 		4 ILE A 233
ARG A 237
TYR A 273
TYR A 289
 None
 0.88A 5iwuA-5iguA:
31.5		 5iwuA-5iguA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l1b GLUTAMATE RECEPTOR
2,GLUTAMATE RECEPTOR
2

(Rattus
norvegicus) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		4 GLY A 230
ASP A 138
ILE A 193
TYR A 280
 None
 1.10A 5iwuA-5l1bA:
undetectable		 5iwuA-5l1bA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l6o EPHRIN TYPE-B
RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 GLY A 835
ASP A 758
ILE A 802
ARG A 803
 None
 1.08A 5iwuA-5l6oA:
6.6		 5iwuA-5l6oA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ljo OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA

(Escherichia
coli) 		PF01103
(Bac_surface_Ag)
PF07244
(POTRA) 		4 GLY A 407
ASP A 401
ILE A 352
TYR A 319
 None
 0.97A 5iwuA-5ljoA:
undetectable		 5iwuA-5ljoA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m41 NIGRITOXINE

(Vibrio
nigripulchritudo) 		no annotation 4 GLY A 339
ILE A 499
TYR A 498
TYR A 545
 None
 1.14A 5iwuA-5m41A:
undetectable		 5iwuA-5m41A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m41 NIGRITOXINE

(Vibrio
nigripulchritudo) 		no annotation 4 GLY A 433
ASP A 196
ILE A 247
ARG A  28
 None
 1.01A 5iwuA-5m41A:
undetectable		 5iwuA-5m41A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mif 'CARBOXYL ESTERASE 2

(Tuber
melanosporum) 		PF07859
(Abhydrolase_3) 		4 GLY A 119
ILE A 132
TYR A 114
TYR A 218
 None
 1.06A 5iwuA-5mifA:
undetectable		 5iwuA-5mifA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nmi CYTOCHROME B
CYTOCHROME C1, HEME
PROTEIN,
MITOCHONDRIAL

(Bos taurus;
Bos taurus) 		PF00032
(Cytochrom_B_C)
PF00033
(Cytochrome_B)
PF02167
(Cytochrom_C1) 		4 GLY D 155
ASP C 254
ILE D 116
TYR D 126
 None
None
HEC  D 501 (-4.3A)
HEC  D 501 (-4.2A)
 1.09A 5iwuA-5nmiD:
undetectable		 5iwuA-5nmiD:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5or7 CAPSID PROTEIN

(Norwalk virus) 		no annotation 5 GLY A 327
ASP A 403
ILE A 420
ARG A 268
TYR A 408
 None
None
None
None
NA  A 600 (-4.5A)
 1.40A 5iwuA-5or7A:
undetectable		 5iwuA-5or7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tu0 LMO2125 PROTEIN

(Listeria
monocytogenes) 		PF13416
(SBP_bac_8) 		4 GLY A 304
ILE A 362
ARG A 347
TYR A 365
 None
 1.10A 5iwuA-5tu0A:
undetectable		 5iwuA-5tu0A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5us8 ARGININOSUCCINATE
SYNTHASE

(Bordetella
pertussis) 		PF00764
(Arginosuc_synth) 		4 GLY A 328
ASP A 136
ILE A 284
TYR A  99
 None
 1.06A 5iwuA-5us8A:
undetectable		 5iwuA-5us8A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ux1 TRNA-(MS(2)IO(6)A)-H
YDROXYLASE-LIKE

(Synechococcus
sp. CC9605) 		no annotation 4 GLY A 121
ILE A 187
TYR A 182
TYR A  67
 None
 1.03A 5iwuA-5ux1A:
undetectable		 5iwuA-5ux1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6exs PEPTIDE ABC
TRANSPORTER PERMEASE

(Staphylococcus
hominis) 		no annotation 4 GLY A 396
ASP A 326
ARG A 324
TYR A 320
 OLC  A 505 (-3.4A)
None
None
None
 1.08A 5iwuA-6exsA:
undetectable		 5iwuA-6exsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fn1 HUMAN-MOUSE CHIMERIC
ABCB1 (ABCBHM)

(Homo sapiens) 		no annotation 4 GLY A1072
ASP A1199
ILE A1227
TYR A1043
 None
 1.13A 5iwuA-6fn1A:
undetectable		 5iwuA-6fn1A:
undetectable