SIMILAR PATTERNS OF AMINO ACIDS FOR 5IWU_A_ERYA404_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b74 GLUTAMATE RACEMASE

(Aquifex
pyrophilus)
PF01177
(Asp_Glu_race)
5 ILE A 175
TYR A 123
THR A  14
ALA A 122
SER A 207
None
1.09A 5iwuA-1b74A:
undetectable
5iwuA-1b74A:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ebv PROSTAGLANDIN H2
SYNTHASE


(Ovis aries)
PF00008
(EGF)
PF03098
(An_peroxidase)
5 ILE A 233
HIS A 232
TYR A 234
ALA A 332
ILE A 343
None
1.42A 5iwuA-1ebvA:
undetectable
5iwuA-1ebvA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gzv GLUCOSE-6-PHOSPHATE
ISOMERASE


(Sus scrofa)
PF00342
(PGI)
5 THR A 167
PHE A 205
ALA A 224
SER A 159
ILE A 156
None
None
None
PA5  A 600 (-3.4A)
None
1.35A 5iwuA-1gzvA:
0.0
5iwuA-1gzvA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jed SULFATE
ADENYLYLTRANSFERASE


(Saccharomyces
cerevisiae)
PF01747
(ATP-sulfurylase)
PF14306
(PUA_2)
5 ILE A  82
THR A  38
ALA A 293
SER A 143
ILE A 142
None
None
ADP  A 635 (-4.4A)
None
None
1.06A 5iwuA-1jedA:
0.0
5iwuA-1jedA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2


(Synechocystis
sp. PCC 6803)
PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central)
5 ILE A 965
HIS A1006
THR A1363
ALA A 968
ILE A1012
None
1.32A 5iwuA-1ofeA:
0.0
5iwuA-1ofeA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t90 PROBABLE
METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE


(Bacillus
subtilis)
PF00171
(Aldedh)
5 ILE A  46
THR A 185
ALA A  54
SER A 225
ILE A 224
None
1.15A 5iwuA-1t90A:
0.0
5iwuA-1t90A:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tmo TRIMETHYLAMINE
N-OXIDE REDUCTASE


(Shewanella
massilia)
PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
5 ILE A 422
TYR A 431
THR A 155
SER A 769
ILE A 759
None
1.43A 5iwuA-1tmoA:
0.0
5iwuA-1tmoA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1to6 GLYCERATE KINASE

(Neisseria
meningitidis)
PF02595
(Gly_kinase)
5 ILE A 247
GLU A 114
PHE A 254
ALA A 253
ILE A 127
None
1.31A 5iwuA-1to6A:
0.0
5iwuA-1to6A:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1to6 GLYCERATE KINASE

(Neisseria
meningitidis)
PF02595
(Gly_kinase)
5 THR A  66
GLU A 114
PHE A 254
ALA A 253
ILE A 127
None
1.44A 5iwuA-1to6A:
0.0
5iwuA-1to6A:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vbl PECTATE LYASE 47

(Bacillus sp.
TS-47)
PF00544
(Pec_lyase_C)
5 THR A  66
ALA A 410
SER A 191
ILE A 192
PHE A 150
None
1.33A 5iwuA-1vblA:
undetectable
5iwuA-1vblA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ve1 O-ACETYLSERINE
SULFHYDRYLASE


(Thermus
thermophilus)
PF00291
(PALP)
5 ILE A 167
THR A  10
GLU A  31
ALA A 275
ILE A 180
None
1.25A 5iwuA-1ve1A:
undetectable
5iwuA-1ve1A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wl4 ACETYL-COENZYME A
ACETYLTRANSFERASE 2


(Homo sapiens)
PF00108
(Thiolase_N)
PF02803
(Thiolase_C)
5 ILE A 280
THR A 365
GLU A 319
ALA A 308
ILE A 390
None
1.41A 5iwuA-1wl4A:
undetectable
5iwuA-1wl4A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x9s DNA POLYMERASE

(Escherichia
virus T7)
PF00476
(DNA_pol_A)
5 ILE A 562
GLU A 480
PHE A 524
ALA A 513
ILE A 500
None
1.17A 5iwuA-1x9sA:
undetectable
5iwuA-1x9sA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xx6 THYMIDINE KINASE

(Clostridium
acetobutylicum)
PF00265
(TK)
5 ILE A 141
GLU A  89
ALA A 152
ILE A 128
MET A 132
None
1.41A 5iwuA-1xx6A:
undetectable
5iwuA-1xx6A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7a CONSERVED
HYPOTHETICAL PROTEIN


(Pseudomonas
aeruginosa)
PF01522
(Polysacc_deac_1)
5 HIS A 259
HIS A 126
THR A 168
ALA A 106
PHE A  53
None
1.26A 5iwuA-1z7aA:
undetectable
5iwuA-1z7aA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c4k PHOSPHORIBOSYL
PYROPHOSPHATE
SYNTHETASE-ASSOCIATE
D PROTEIN 1


(Homo sapiens)
PF13793
(Pribosyltran_N)
PF14572
(Pribosyl_synth)
5 ILE A  92
THR A  47
GLU A  76
PHE A  11
ILE A  96
None
1.42A 5iwuA-2c4kA:
undetectable
5iwuA-2c4kA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cun PHOSPHOGLYCERATE
KINASE


(Pyrococcus
horikoshii)
PF00162
(PGK)
5 HIS A  72
ALA A 148
SER A 116
ILE A  90
PHE A 115
None
None
None
MPD  A 509 (-3.9A)
None
1.16A 5iwuA-2cunA:
undetectable
5iwuA-2cunA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cxn GLUCOSE-6-PHOSPHATE
ISOMERASE


(Mus musculus)
PF00342
(PGI)
5 THR A 168
PHE A 206
ALA A 225
SER A 160
ILE A 157
None
None
None
PO4  A1601 (-2.7A)
None
1.32A 5iwuA-2cxnA:
undetectable
5iwuA-2cxnA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f3o PYRUVATE
FORMATE-LYASE 2


(Archaeoglobus
fulgidus)
PF01228
(Gly_radical)
PF02901
(PFL-like)
5 ILE A 314
HIS A 265
THR A 511
GLU A 267
ILE A  54
None
1.44A 5iwuA-2f3oA:
undetectable
5iwuA-2f3oA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g7g RHA04620, PUTATIVE
TRANSCRIPTIONAL
REGULATOR


(Rhodococcus
jostii)
PF02909
(TetR_C)
5 ILE A 132
GLU A  72
PHE A  80
ALA A 139
SER A 113
None
1.23A 5iwuA-2g7gA:
undetectable
5iwuA-2g7gA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gfp MULTIDRUG RESISTANCE
PROTEIN D


(Escherichia
coli)
PF07690
(MFS_1)
5 ILE A 217
GLU A 326
ALA A 337
SER A 207
MET A 372
None
1.18A 5iwuA-2gfpA:
undetectable
5iwuA-2gfpA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gx8 NIF3-RELATED PROTEIN

(Bacillus cereus)
PF01784
(NIF3)
5 ILE A  99
THR A  81
GLU A  90
ALA A  35
ILE A  58
None
1.39A 5iwuA-2gx8A:
undetectable
5iwuA-2gx8A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h12 CITRATE SYNTHASE

(Acetobacter
aceti)
PF00285
(Citrate_synt)
5 ILE A  81
HIS A  76
THR A 243
ALA A  88
PHE A 392
None
None
None
None
CMX  A5001 (-4.9A)
1.39A 5iwuA-2h12A:
undetectable
5iwuA-2h12A:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nwb CONSERVED DOMAIN
PROTEIN


(Shewanella
oneidensis)
PF08933
(DUF1864)
5 ILE A 245
TYR A 163
GLU A 315
ALA A 162
PHE A 310
None
HEM  A 401 ( 4.8A)
None
None
None
1.30A 5iwuA-2nwbA:
undetectable
5iwuA-2nwbA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1s 1-DEOXY-D-XYLULOSE-5
-PHOSPHATE SYNTHASE


(Escherichia
coli)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C)
PF13292
(DXP_synthase_N)
5 THR A  56
ALA A 367
SER A 126
ILE A 127
MET A 164
None
1.39A 5iwuA-2o1sA:
undetectable
5iwuA-2o1sA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o2c GLUCOSE-6-PHOSPHATE
ISOMERASE,
GLYCOSOMAL


(Trypanosoma
brucei)
PF00342
(PGI)
5 THR A 216
PHE A 254
ALA A 273
SER A 208
ILE A 205
None
None
None
G6Q  A5001 (-2.7A)
None
1.35A 5iwuA-2o2cA:
undetectable
5iwuA-2o2cA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2odp COMPLEMENT C2

(Homo sapiens)
PF00089
(Trypsin)
PF00092
(VWA)
5 THR A 640
ALA A 475
SER A 521
ILE A 520
PHE A 524
None
1.36A 5iwuA-2odpA:
undetectable
5iwuA-2odpA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q3o 12-OXOPHYTODIENOATE
REDUCTASE 3


(Arabidopsis
thaliana)
PF00724
(Oxidored_FMN)
5 ILE A 185
THR A  33
PHE A 104
ALA A 276
SER A 320
None
FMN  A7401 (-3.8A)
None
None
FMN  A7401 ( 4.2A)
1.29A 5iwuA-2q3oA:
undetectable
5iwuA-2q3oA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qt3 N-ISOPROPYLAMMELIDE
ISOPROPYL
AMIDOHYDROLASE


(Pseudomonas sp.
ADP)
PF01979
(Amidohydro_1)
5 GLU A 197
PHE A 163
ALA A 159
SER A 228
ILE A 229
None
1.25A 5iwuA-2qt3A:
undetectable
5iwuA-2qt3A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qt3 N-ISOPROPYLAMMELIDE
ISOPROPYL
AMIDOHYDROLASE


(Pseudomonas sp.
ADP)
PF01979
(Amidohydro_1)
5 ILE A 214
GLU A 197
PHE A 163
ALA A 159
ILE A 229
None
1.35A 5iwuA-2qt3A:
undetectable
5iwuA-2qt3A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r9h H(+)/CL(-) EXCHANGE
TRANSPORTER CLCA


(Escherichia
coli)
PF00654
(Voltage_CLC)
5 ILE A 410
THR A 226
ALA A 404
ILE A 215
PHE A 219
None
1.13A 5iwuA-2r9hA:
undetectable
5iwuA-2r9hA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w7y PROBABLE SUGAR ABC
TRANSPORTER,
SUGAR-BINDING
PROTEIN


(Streptococcus
pneumoniae)
PF13416
(SBP_bac_8)
5 HIS A 395
THR A 149
SER A 303
ILE A 302
PHE A 155
None
None
None
None
GAL  A1429 ( 4.5A)
1.43A 5iwuA-2w7yA:
undetectable
5iwuA-2w7yA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ww2 ALPHA-1,2-MANNOSIDAS
E


(Bacteroides
thetaiotaomicron)
PF07971
(Glyco_hydro_92)
5 HIS A  89
PHE A  61
ALA A  54
SER A 102
ILE A 103
None
1.40A 5iwuA-2ww2A:
undetectable
5iwuA-2ww2A:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wzs PUTATIVE
ALPHA-1,2-MANNOSIDAS
E


(Bacteroides
thetaiotaomicron)
PF07971
(Glyco_hydro_92)
5 HIS A  83
PHE A  55
ALA A  48
SER A  96
ILE A  97
None
1.42A 5iwuA-2wzsA:
1.1
5iwuA-2wzsA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yg6 PUTRESCINE OXIDASE

(Rhodococcus
erythropolis)
PF01593
(Amino_oxidase)
5 ILE A 272
ALA A  36
SER A 421
ILE A 261
PHE A 420
None
FAD  A 600 (-3.5A)
None
None
None
1.36A 5iwuA-2yg6A:
undetectable
5iwuA-2yg6A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yky BETA-TRANSAMINASE

(Mesorhizobium
sp. LUK)
PF00202
(Aminotran_3)
5 ILE A 217
THR A 257
GLU A 254
ALA A 156
SER A 135
None
1.15A 5iwuA-2ykyA:
undetectable
5iwuA-2ykyA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zxq ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE


(Bifidobacterium
longum)
PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C)
5 ILE A 620
HIS A 435
PHE A 516
ALA A 614
MET A 350
None
1.24A 5iwuA-2zxqA:
0.5
5iwuA-2zxqA:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a2f DNA POLYMERASE

(Pyrococcus
furiosus)
PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1)
5 ILE A 663
TYR A 702
GLU A 735
ALA A 715
ILE A 656
None
1.43A 5iwuA-3a2fA:
undetectable
5iwuA-3a2fA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b57 LIN1889 PROTEIN

(Listeria
innocua)
PF01966
(HD)
5 ILE A  85
THR A 113
GLU A 115
PHE A  57
ALA A  10
None
1.37A 5iwuA-3b57A:
undetectable
5iwuA-3b57A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cl6 PUUE ALLANTOINASE

(Pseudomonas
fluorescens)
PF01522
(Polysacc_deac_1)
5 HIS A 259
HIS A 126
THR A 168
ALA A 106
PHE A  53
None
1.22A 5iwuA-3cl6A:
undetectable
5iwuA-3cl6A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cq5 HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE


(Corynebacterium
glutamicum)
PF00155
(Aminotran_1_2)
5 ILE A 247
THR A 210
PHE A 109
ALA A 108
SER A  98
None
None
None
None
PMP  A 401 (-3.3A)
1.31A 5iwuA-3cq5A:
undetectable
5iwuA-3cq5A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dh4 SODIUM/GLUCOSE
COTRANSPORTER


(Vibrio
parahaemolyticus)
PF00474
(SSF)
5 ILE A  97
THR A 514
ALA A 528
ILE A 271
PHE A 106
None
1.37A 5iwuA-3dh4A:
undetectable
5iwuA-3dh4A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjb GLUCOSE-6-PHOSPHATE
ISOMERASE


(Vibrio cholerae)
PF00342
(PGI)
5 THR A 167
PHE A 204
ALA A 223
SER A 159
ILE A 156
None
1.35A 5iwuA-3hjbA:
undetectable
5iwuA-3hjbA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjw PSEUDOURIDINE
SYNTHASE CBF5


(Pyrococcus
furiosus)
PF01472
(PUA)
PF01509
(TruB_N)
PF08068
(DKCLD)
PF16198
(TruB_C_2)
5 ILE A 187
GLU A 162
PHE A 135
ALA A 193
ILE A 166
None
1.34A 5iwuA-3hjwA:
undetectable
5iwuA-3hjwA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3my9 MUCONATE
CYCLOISOMERASE


(Azorhizobium
caulinodans)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
5 ILE A 209
HIS A 173
PHE A 236
PHE A 216
MET A 166
None
1.36A 5iwuA-3my9A:
undetectable
5iwuA-3my9A:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nbu GLUCOSE-6-PHOSPHATE
ISOMERASE


(Escherichia
coli)
PF00342
(PGI)
5 THR A 166
PHE A 203
ALA A 222
SER A 158
ILE A 155
None
1.26A 5iwuA-3nbuA:
undetectable
5iwuA-3nbuA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o6b DEFECTIVE IN CULLIN
NEDDYLATION PROTEIN
1
CELL DIVISION
CONTROL PROTEIN 53


(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae)
PF03556
(Cullin_binding)
PF10557
(Cullin_Nedd8)
5 ILE B 793
TYR B 811
HIS B 767
GLU A 250
ILE A 257
None
0.98A 5iwuA-3o6bB:
undetectable
5iwuA-3o6bB:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3prl NADP-DEPENDENT
GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE


(Bacillus
halodurans)
PF00171
(Aldedh)
5 ILE A 117
THR A 238
ALA A 124
ILE A 212
PHE A 185
None
1.40A 5iwuA-3prlA:
undetectable
5iwuA-3prlA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qgu LL-DIAMINOPIMELATE
AMINOTRANSFERASE


(Chlamydomonas
reinhardtii)
PF00155
(Aminotran_1_2)
5 ILE A 244
THR A 263
GLU A 276
ALA A 159
SER A 141
None
None
None
None
SO4  A 451 (-4.8A)
1.44A 5iwuA-3qguA:
undetectable
5iwuA-3qguA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3thw DNA MISMATCH REPAIR
PROTEIN MSH3


(Homo sapiens)
PF00488
(MutS_V)
PF01624
(MutS_I)
PF05188
(MutS_II)
PF05192
(MutS_III)
5 ILE B 666
HIS B 818
ALA B 820
SER B 656
ILE B 654
None
1.13A 5iwuA-3thwB:
undetectable
5iwuA-3thwB:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tzw POLYKETIDE SYNTHASE
PKS13


(Mycobacterium
tuberculosis)
PF00698
(Acyl_transf_1)
5 ILE A1041
TYR A1033
HIS A 670
ALA A 675
ILE A 661
None
1.41A 5iwuA-3tzwA:
undetectable
5iwuA-3tzwA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wrf NON-REDUCING END
BETA-L-ARABINOFURANO
SIDASE


(Bifidobacterium
longum)
PF07944
(Glyco_hydro_127)
5 ILE A 138
TYR A 231
GLU A 196
ALA A 257
SER A 217
None
1.39A 5iwuA-3wrfA:
undetectable
5iwuA-3wrfA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x3y PHENYLETHYLAMINE
OXIDASE


(Arthrobacter
globiformis)
PF01179
(Cu_amine_oxid)
PF02728
(Cu_amine_oxidN3)
5 THR A 377
PHE A 297
ALA A 534
SER A 276
PHE A 398
None
1.42A 5iwuA-3x3yA:
3.4
5iwuA-3x3yA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bg2 PATF

(Prochloron
didemni)
no annotation 5 HIS A 140
GLU A 180
ALA A 108
SER A 236
PHE A 234
None
1.34A 5iwuA-4bg2A:
undetectable
5iwuA-4bg2A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ff5 GLYCOSYL HYDROLASE
25


(Streptococcus
pneumoniae)
PF01183
(Glyco_hydro_25)
5 ILE A  77
HIS A  60
GLU A 108
PHE A 116
ALA A 120
None
1.43A 5iwuA-4ff5A:
undetectable
5iwuA-4ff5A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fwb HALOALKANE
DEHALOGENASE


(Rhodococcus
rhodochrous)
PF00561
(Abhydrolase_1)
5 HIS A 272
GLU A 276
PHE A 245
ALA A 145
ILE A 169
CL  A2003 ( 3.7A)
None
CL  A2003 ( 4.7A)
None
None
1.31A 5iwuA-4fwbA:
undetectable
5iwuA-4fwbA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kc3 INTERLEUKIN-33
INTERLEUKIN-1
RECEPTOR-LIKE 1


(Homo sapiens;
Homo sapiens)
PF15095
(IL33)
PF07679
(I-set)
5 ILE B 214
HIS B 314
PHE B 239
ALA B 248
SER A 170
None
1.28A 5iwuA-4kc3B:
undetectable
5iwuA-4kc3B:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l95 GAMMA-GLUTAMYL
HYDROLASE


(Danio rerio)
no annotation 5 ILE E 238
THR E 227
GLU E 285
PHE E  37
ALA E 245
None
1.41A 5iwuA-4l95E:
undetectable
5iwuA-4l95E:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lyp EXO-BETA-1,4-MANNOSI
DASE


(Rhizomucor
miehei)
no annotation 5 TYR A 156
THR A 253
PHE A 116
ALA A 152
ILE A 173
None
1.32A 5iwuA-4lypA:
undetectable
5iwuA-4lypA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m64 MELIBIOSE CARRIER
PROTEIN


(Salmonella
enterica)
PF13347
(MFS_2)
5 ILE A 415
THR A 425
ALA A 254
SER A 380
PHE A 386
None
1.23A 5iwuA-4m64A:
undetectable
5iwuA-4m64A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mll BETA-LACTAMASE OXA-1

(Escherichia
coli)
PF00905
(Transpeptidase)
5 ILE A 167
TYR A 141
THR A 219
ALA A  72
SER A 258
None
None
None
None
1S6  A 301 (-2.4A)
1.16A 5iwuA-4mllA:
undetectable
5iwuA-4mllA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mll BETA-LACTAMASE OXA-1

(Escherichia
coli)
PF00905
(Transpeptidase)
5 TYR A 141
THR A 219
PHE A  69
ALA A  72
SER A 258
None
None
None
None
1S6  A 301 (-2.4A)
0.94A 5iwuA-4mllA:
undetectable
5iwuA-4mllA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nwz FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE


(Caldalkalibacillus
thermarum)
PF07992
(Pyr_redox_2)
5 ILE A 387
TYR A 383
HIS A  42
ALA A 316
ILE A   8
None
None
None
FAD  A 601 (-3.6A)
None
1.26A 5iwuA-4nwzA:
undetectable
5iwuA-4nwzA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o6d NS1

(West Nile virus)
PF00948
(Flavi_NS1)
5 ILE B 275
TYR B 323
GLU B 219
ALA B 297
SER B 222
None
1.36A 5iwuA-4o6dB:
undetectable
5iwuA-4o6dB:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4omg GERANYLGERANYL
DIPHOSPHATE CYCLASE


(Streptomyces
melanosporofaciens)
no annotation 5 THR A  47
GLU A  50
ALA A  60
PHE A  96
MET A 189
None
1.44A 5iwuA-4omgA:
undetectable
5iwuA-4omgA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4opu CONSERVED ARCHAEAL
PROTEIN


(Sulfolobus
acidocaldarius)
PF01266
(DAO)
5 ILE A  10
THR A 292
PHE A 163
ALA A 122
ILE A  42
None
None
None
FDA  A 501 (-4.0A)
None
1.44A 5iwuA-4opuA:
undetectable
5iwuA-4opuA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oqz PUTATIVE
OXIDOREDUCTASE YFJR


(Streptomyces
aurantiacus)
PF03446
(NAD_binding_2)
5 TYR A  69
HIS A 113
ALA A 166
ILE A 151
MET A  17
None
1.36A 5iwuA-4oqzA:
undetectable
5iwuA-4oqzA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pj3 INTRON-BINDING
PROTEIN AQUARIUS


(Homo sapiens)
PF13086
(AAA_11)
PF13087
(AAA_12)
PF16399
(Aquarius_N)
5 THR A1229
ALA A1139
SER A1225
ILE A1224
MET A1214
None
1.35A 5iwuA-4pj3A:
undetectable
5iwuA-4pj3A:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v1y ATRAZINE
CHLOROHYDROLASE


(Pseudomonas sp.
ADP)
PF01979
(Amidohydro_1)
5 TYR A 111
THR A 241
ALA A 115
SER A 210
ILE A 209
None
1.17A 5iwuA-4v1yA:
undetectable
5iwuA-4v1yA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v39 SIALYLTRANSFERASE

(Pasteurella
dagmatis)
PF11477
(PM0188)
5 ILE A 150
TYR A 144
HIS A  91
GLU A  62
PHE A  90
None
1.36A 5iwuA-4v39A:
undetectable
5iwuA-4v39A:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wmj GLUCOSE-6-PHOSPHATE
ISOMERASE


(Colias
eurytheme)
PF00342
(PGI)
5 THR A 172
PHE A 209
ALA A 228
SER A 164
ILE A 161
None
1.34A 5iwuA-4wmjA:
undetectable
5iwuA-4wmjA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wso PROBABLE
NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE


(Burkholderia
thailandensis)
PF01467
(CTP_transf_like)
5 ILE A 135
THR A 202
ALA A 156
ILE A 179
PHE A 168
NAD  A 301 (-4.1A)
None
None
None
None
1.38A 5iwuA-4wsoA:
undetectable
5iwuA-4wsoA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wxx DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1


(Homo sapiens)
PF00145
(DNA_methylase)
PF01426
(BAH)
PF02008
(zf-CXXC)
PF12047
(DNMT1-RFD)
5 ILE A1314
PHE A1263
ALA A1317
SER A1161
ILE A1160
None
1.36A 5iwuA-4wxxA:
undetectable
5iwuA-4wxxA:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ygu PUTATIVE ADHESIN

(Bacteroides
eggerthii)
PF10988
(DUF2807)
5 ILE A  49
GLU A 112
PHE A  38
ALA A 105
SER A 131
None
1.32A 5iwuA-4yguA:
undetectable
5iwuA-4yguA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yue S4B6 FAB HEAVY CHAIN
S4B6 FAB LIGHT CHAIN


(Mus musculus;
Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
PF07654
(C1-set)
PF07686
(V-set)
5 TYR L  99
HIS L  94
THR L  55
PHE H 113
SER H 107
None
1.37A 5iwuA-4yueL:
undetectable
5iwuA-4yueL:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b2d HN PROTEIN

(Mumps
rubulavirus)
PF00423
(HN)
5 ILE A 387
THR A 295
GLU A 393
PHE A 320
ALA A 247
None
1.13A 5iwuA-5b2dA:
0.6
5iwuA-5b2dA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bnn CAPSID PROTEIN VP2

(Enterovirus D)
PF00073
(Rhv)
5 ILE B 108
GLU B 150
PHE B  63
SER B  68
ILE B 228
None
1.22A 5iwuA-5bnnB:
undetectable
5iwuA-5bnnB:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c1b TRANSITIONAL
ENDOPLASMIC
RETICULUM ATPASE


(Homo sapiens)
PF00004
(AAA)
PF02359
(CDC48_N)
PF02933
(CDC48_2)
PF09336
(Vps4_C)
5 ILE A 371
HIS A 404
ALA A 374
SER A 541
ILE A 540
None
1.44A 5iwuA-5c1bA:
undetectable
5iwuA-5c1bA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c9l PLL LECTIN

(Photorhabdus
luminescens)
PF03984
(DUF346)
5 ILE A 265
PHE A 234
ALA A 271
SER A 171
ILE A  22
None
1.36A 5iwuA-5c9lA:
4.0
5iwuA-5c9lA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gut DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1


(Mus musculus)
PF00145
(DNA_methylase)
PF01426
(BAH)
5 ILE A1317
PHE A1266
ALA A1320
SER A1164
ILE A1163
None
1.44A 5iwuA-5gutA:
undetectable
5iwuA-5gutA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h2v IMPORTIN SUBUNIT
BETA-3


(Saccharomyces
cerevisiae)
PF13513
(HEAT_EZ)
5 GLU A 396
ALA A 473
SER A 440
ILE A 443
PHE A 439
None
1.17A 5iwuA-5h2vA:
undetectable
5iwuA-5h2vA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hab RIBONUCLEASE J

(Methanolobus
psychrophilus)
PF07521
(RMMBL)
PF12706
(Lactamase_B_2)
5 ILE A 154
HIS A  82
THR A 208
GLU A 206
ALA A 104
None
None
A  C   1 ( 4.4A)
None
None
1.19A 5iwuA-5habA:
undetectable
5iwuA-5habA:
23.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5igu MACROLIDE
2'-PHOSPHOTRANSFERAS
E II


(Escherichia
coli)
PF01636
(APH)
5 HIS A 202
PHE A 234
ALA A 238
ILE A 277
PHE A 280
None
1.29A 5iwuA-5iguA:
31.5
5iwuA-5iguA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5igu MACROLIDE
2'-PHOSPHOTRANSFERAS
E II


(Escherichia
coli)
PF01636
(APH)
5 HIS A 202
THR A 221
GLU A 222
PHE A 234
ALA A 238
None
1.08A 5iwuA-5iguA:
31.5
5iwuA-5iguA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5igu MACROLIDE
2'-PHOSPHOTRANSFERAS
E II


(Escherichia
coli)
PF01636
(APH)
5 PHE A 234
ALA A 238
SER A 276
ILE A 277
PHE A 280
None
0.76A 5iwuA-5iguA:
31.5
5iwuA-5iguA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5igu MACROLIDE
2'-PHOSPHOTRANSFERAS
E II


(Escherichia
coli)
PF01636
(APH)
5 THR A 221
GLU A 222
PHE A 234
ALA A 238
SER A 276
None
0.39A 5iwuA-5iguA:
31.5
5iwuA-5iguA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k04 UNCHARACTERIZED
PROTEIN


(Candida
albicans)
PF09797
(NatB_MDM20)
5 ILE A 432
TYR A 427
HIS A 437
THR A 466
SER A 500
None
1.41A 5iwuA-5k04A:
undetectable
5iwuA-5k04A:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lki TCDA1

(Photorhabdus
luminescens)
PF03538
(VRP1)
5 THR A1054
GLU A1143
PHE A1110
ALA A1096
ILE A1203
None
1.21A 5iwuA-5lkiA:
3.1
5iwuA-5lkiA:
8.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ng6 CRISPR-ASSOCIATED
ENDONUCLEASE CPF1


(Francisella
tularensis)
no annotation 5 ILE A1085
HIS A1261
ALA A1138
ILE A1286
MET A1268
None
1.13A 5iwuA-5ng6A:
undetectable
5iwuA-5ng6A:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u4n FRUCTOSE-1

(Neisseria
gonorrhoeae)
PF01116
(F_bP_aldolase)
5 HIS A  84
THR A 196
ALA A  51
ILE A  46
MET A   6
PO4  A 402 (-3.6A)
None
None
None
None
1.24A 5iwuA-5u4nA:
undetectable
5iwuA-5u4nA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zhg OUTER CAPSID PROTEIN
VP8*


(Rotavirus C)
no annotation 5 ILE A 150
HIS A  37
PHE A 141
SER A 114
ILE A  17
None
1.35A 5iwuA-5zhgA:
1.4
5iwuA-5zhgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ax8 METHIONINE-TRNA
LIGASE


(Mycobacterium
tuberculosis)
no annotation 5 ILE A 260
HIS A 268
PHE A 332
ALA A  27
PHE A 183
None
ME8  A 801 (-4.6A)
None
None
None
1.44A 5iwuA-6ax8A:
undetectable
5iwuA-6ax8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6brd RIFAMPIN
MONOOXYGENASE


(Streptomyces
venezuelae)
no annotation 5 TYR A 403
HIS A  90
THR A  68
ILE A 294
MET A  15
None
1.26A 5iwuA-6brdA:
undetectable
5iwuA-6brdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7y TYROSINE-PROTEIN
KINASE JAK1
SUPPRESSOR OF
CYTOKINE SIGNALING 1


(Homo sapiens;
Gallus gallus)
no annotation
no annotation
5 ALA B  76
SER B  66
ILE B  67
PHE B  64
MET A1099
None
1.39A 5iwuA-6c7yB:
undetectable
5iwuA-6c7yB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2


(Saccharomyces
cerevisiae)
no annotation 5 HIS A 946
GLU A1208
ALA A 940
SER A 990
ILE A 991
None
1.35A 5iwuA-6emkA:
1.6
5iwuA-6emkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f4f GLUTATHIONE
TRANSFERASE


(Trametes
versicolor)
no annotation 5 ILE A 166
TYR A 206
PHE A 111
ALA A 154
SER A  81
None
None
None
None
GDN  A 301 (-2.6A)
1.44A 5iwuA-6f4fA:
undetectable
5iwuA-6f4fA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5o POLYMERASE ACIDIC
PROTEIN


(Influenza B
virus)
no annotation 5 ILE A 269
HIS A 268
TYR A 270
SER A 658
ILE A 686
None
1.42A 5iwuA-6f5oA:
undetectable
5iwuA-6f5oA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fm9 UDP-N-ACETYLGLUCOSAM
INE--DOLICHYL-PHOSPH
ATE
N-ACETYLGLUCOSAMINEP
HOSPHOTRANSFERASE


(Homo sapiens)
no annotation 5 ALA A 183
SER A 204
ILE A 205
PHE A 208
MET A 228
None
P6L  A 501 (-3.4A)
None
None
None
1.39A 5iwuA-6fm9A:
undetectable
5iwuA-6fm9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g2j NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
5


(Mus musculus)
no annotation 5 ILE L 302
PHE L 335
SER L  99
ILE L 100
PHE L 103
None
1.32A 5iwuA-6g2jL:
undetectable
5iwuA-6g2jL:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g2j NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
5


(Mus musculus)
no annotation 5 THR L 369
PHE L 335
SER L  99
ILE L 100
PHE L 103
None
1.36A 5iwuA-6g2jL:
undetectable
5iwuA-6g2jL:
undetectable