SIMILAR PATTERNS OF AMINO ACIDS FOR 5IWU_A_ACTA402

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1amu GRAMICIDIN
SYNTHETASE 1

(Brevibacillus
brevis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 PHE A  81
VAL A 109
MET A  96
ILE A  94
 None
 1.15A 5iwuA-1amuA:
0.0		 5iwuA-1amuA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bxt PROTEIN
(STREPTOCOCCAL
SUPERANTIGEN)

(Streptococcus
pyogenes) 		PF01123
(Stap_Strp_toxin)
PF02876
(Stap_Strp_tox_C) 		4 PHE A 142
VAL A 130
ILE A 183
ASP A 157
 None
 1.30A 5iwuA-1bxtA:
undetectable		 5iwuA-1bxtA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ezf FARNESYL-DIPHOSPHATE
FARNESYLTRANSFERASE

(Homo sapiens) 		PF00494
(SQS_PSY) 		4 PHE A 210
VAL A 273
MET A 342
ILE A 338
 None
 1.20A 5iwuA-1ezfA:
undetectable		 5iwuA-1ezfA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1izo CYTOCHROME P450
152A1

(Bacillus
subtilis) 		PF00067
(p450) 		4 PHE A 301
VAL A 297
MET A  49
ILE A  47
 None
 1.05A 5iwuA-1izoA:
0.0		 5iwuA-1izoA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jny ELONGATION FACTOR
1-ALPHA

(Sulfolobus
solfataricus) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2) 		4 PHE A 189
VAL A 149
MET A 126
ILE A 136
 None
 1.05A 5iwuA-1jnyA:
0.0		 5iwuA-1jnyA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kbv MAJOR OUTER MEMBRANE
PROTEIN PAN 1

(Neisseria
gonorrhoeae) 		PF00394
(Cu-oxidase)
PF07732
(Cu-oxidase_3) 		4 PHE A 123
VAL A  80
MET A  43
ILE A  72
 None
 1.31A 5iwuA-1kbvA:
undetectable		 5iwuA-1kbvA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1li7 CYSTEINYL-TRNA
SYNTHETASE

(Escherichia
coli) 		PF01406
(tRNA-synt_1e)
PF09190
(DALR_2) 		4 PHE A  47
VAL A  50
ILE A   4
ASP A 349
 None
 0.97A 5iwuA-1li7A:
undetectable		 5iwuA-1li7A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mz5 SIALIDASE

(Trypanosoma
rangeli) 		PF13385
(Laminin_G_3)
PF13859
(BNR_3) 		4 PHE A  35
VAL A  32
TYR A  55
ILE A  82
 None
 1.30A 5iwuA-1mz5A:
1.1		 5iwuA-1mz5A:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nfp LUXF GENE PRODUCT

(Photobacterium
leiognathi) 		PF00296
(Bac_luciferase) 		4 PHE A  10
VAL A  45
MET A 211
ILE A  35
 None
 1.20A 5iwuA-1nfpA:
undetectable		 5iwuA-1nfpA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1now BETA-HEXOSAMINIDASE
BETA CHAIN

(Homo sapiens) 		PF00728
(Glyco_hydro_20)
PF14845
(Glycohydro_20b2) 		4 PHE A 337
VAL A 391
TYR A 387
ILE A 322
 None
 1.27A 5iwuA-1nowA:
0.0		 5iwuA-1nowA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ose PORCINE
ALPHA-AMYLASE

(Sus scrofa) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C) 		4 PHE A 429
MET A 394
ILE A 453
ASP A 451
 None
 1.26A 5iwuA-1oseA:
undetectable		 5iwuA-1oseA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE

(Escherichia
coli) 		PF01156
(IU_nuc_hydro) 		4 PHE A 298
VAL A 302
MET A 220
ILE A  18
 None
 1.31A 5iwuA-1q8fA:
undetectable		 5iwuA-1q8fA:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qd1 FORMIMINOTRANSFERASE
-CYCLODEAMINASE

(Sus scrofa) 		PF02971
(FTCD)
PF07837
(FTCD_N) 		4 VAL A  38
TYR A  49
ILE A  20
ASP A  21
 None
 1.21A 5iwuA-1qd1A:
undetectable		 5iwuA-1qd1A:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tmo TRIMETHYLAMINE
N-OXIDE REDUCTASE

(Shewanella
massilia) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		4 VAL A  51
TYR A  52
MET A  21
ILE A  28
 None
 1.20A 5iwuA-1tmoA:
undetectable		 5iwuA-1tmoA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vkh PUTATIVE SERINE
HYDROLASE

(Saccharomyces
cerevisiae) 		PF07859
(Abhydrolase_3) 		4 PHE A 148
VAL A 107
TYR A  34
ILE A  57
 None
 0.97A 5iwuA-1vkhA:
undetectable		 5iwuA-1vkhA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w5t ORC2

(Aeropyrum
pernix) 		PF09079
(Cdc6_C)
PF13401
(AAA_22) 		4 PHE A 182
VAL A 142
MET A 150
ILE A 103
 None
 0.99A 5iwuA-1w5tA:
undetectable		 5iwuA-1w5tA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xxg ENTEROTOXIN

(Staphylococcus
aureus) 		PF01123
(Stap_Strp_toxin)
PF02876
(Stap_Strp_tox_C) 		4 PHE A 140
VAL A 128
ILE A 181
ASP A 155
 None
 1.25A 5iwuA-1xxgA:
undetectable		 5iwuA-1xxgA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yq9 PERIPLASMIC [NIFE]
HYDROGENASE SMALL
SUBUNIT

(Desulfovibrio
gigas) 		PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		4 PHE A 155
VAL A 156
MET A  42
ILE A  40
 None
 1.13A 5iwuA-1yq9A:
undetectable		 5iwuA-1yq9A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gah HETEROTETRAMERIC
SARCOSINE OXIDASE
ALPHA-SUBUNIT

(Stenotrophomonas
maltophilia) 		PF01571
(GCV_T)
PF07992
(Pyr_redox_2)
PF08669
(GCV_T_C)
PF13510
(Fer2_4) 		4 PHE A 777
MET A 843
ILE A 826
ASP A 831
 None
 1.30A 5iwuA-2gahA:
undetectable		 5iwuA-2gahA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ocz 3-DEHYDROQUINATE
DEHYDRATASE

(Streptococcus
pyogenes) 		PF01487
(DHquinase_I) 		4 VAL A   4
TYR A 198
ILE A 114
ASP A  94
 None
 1.26A 5iwuA-2oczA:
undetectable		 5iwuA-2oczA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2odp COMPLEMENT C2

(Homo sapiens) 		PF00089
(Trypsin)
PF00092
(VWA) 		4 PHE A 527
VAL A 526
TYR A 538
MET A 628
 None
 1.14A 5iwuA-2odpA:
undetectable		 5iwuA-2odpA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ox1 3-DEHYDROQUINATE
DEHYDRATASE

(Archaeoglobus
fulgidus) 		PF01487
(DHquinase_I) 		4 VAL A   4
TYR A 171
ILE A  94
ASP A  77
 None
GOL  A 201 ( 4.5A)
None
None
 1.27A 5iwuA-2ox1A:
undetectable		 5iwuA-2ox1A:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p6p GLYCOSYL TRANSFERASE

(Streptomyces
fradiae) 		PF06722
(DUF1205) 		4 PHE A   5
VAL A 112
MET A 189
ILE A 171
 None
 1.29A 5iwuA-2p6pA:
undetectable		 5iwuA-2p6pA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qri H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN K-B ALPHA
CHAIN, BETA-2
MICROGLOBULIN,
OVALBUMIN-DERIVED
PEPTIDE

(Mus musculus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		4 PHE A  33
VAL A  34
TYR A  45
ILE A   2
 None
 1.27A 5iwuA-2qriA:
undetectable		 5iwuA-2qriA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rck JUVENILE HORMONE
BINDING PROTEIN

(Galleria
mellonella) 		PF06585
(JHBP) 		4 PHE A  78
VAL A  87
TYR A 128
ILE A 209
 None
 1.15A 5iwuA-2rckA:
2.0		 5iwuA-2rckA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE

(Paraburkholderia
xenovorans) 		PF12697
(Abhydrolase_6) 		4 PHE A  59
VAL A  36
MET A 135
ILE A 133
 None
 1.05A 5iwuA-2ri6A:
undetectable		 5iwuA-2ri6A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2u1a U1 SMALL NUCLEAR
RIBONUCLEOPROTEIN A

(Homo sapiens) 		PF00076
(RRM_1) 		4 PHE A  34
VAL A  55
MET A  81
ILE A  83
 None
 1.13A 5iwuA-2u1aA:
undetectable		 5iwuA-2u1aA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x0s PYRUVATE PHOSPHATE
DIKINASE

(Trypanosoma
brucei) 		PF00391
(PEP-utilizers)
PF01326
(PPDK_N)
PF02896
(PEP-utilizers_C) 		4 PHE A 436
VAL A 434
TYR A 520
MET A 501
 None
 1.24A 5iwuA-2x0sA:
undetectable		 5iwuA-2x0sA:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xs5 DELETED IN
AZOOSPERMIA-LIKE

(Mus musculus) 		PF00076
(RRM_1) 		4 PHE A  60
VAL A  85
MET A  51
ILE A  47
 None
 1.22A 5iwuA-2xs5A:
undetectable		 5iwuA-2xs5A:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yww ASPARTATE
CARBAMOYLTRANSFERASE
REGULATORY CHAIN

(Methanocaldococcus
jannaschii) 		PF01948
(PyrI)
PF02748
(PyrI_C) 		4 VAL A  47
MET A  42
ILE A  57
ASP A  19
 ATP  A 402 (-4.4A)
ATP  A 402 ( 3.3A)
None
ATP  A 403 (-3.4A)
 1.09A 5iwuA-2ywwA:
undetectable		 5iwuA-2ywwA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a1z HEMOLYMPH JUVENILE
HORMONE BINDING
PROTEIN

(Bombyx mori) 		PF06585
(JHBP) 		4 PHE A  78
VAL A  87
TYR A 128
ILE A 208
 None
 1.18A 5iwuA-3a1zA:
undetectable		 5iwuA-3a1zA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3abg BILIRUBIN OXIDASE

(Albifimbria
verrucaria) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 VAL A 216
TYR A 221
MET A 176
ILE A 174
 None
 1.05A 5iwuA-3abgA:
undetectable		 5iwuA-3abgA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aut GLUCOSE
1-DEHYDROGENASE 4

(Bacillus
megaterium) 		PF13561
(adh_short_C2) 		4 PHE A  27
VAL A  10
MET A 143
ILE A 141
 None
 1.26A 5iwuA-3autA:
undetectable		 5iwuA-3autA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b2d CD180 ANTIGEN

(Homo sapiens) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		4 PHE A 229
VAL A 211
MET A 193
ILE A 164
 None
 1.05A 5iwuA-3b2dA:
undetectable		 5iwuA-3b2dA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c5o UPF0311 PROTEIN
RPA1785

(Rhodopseudomonas
palustris) 		PF11578
(DUF3237) 		4 PHE A 119
VAL A  84
TYR A  72
ILE A  13
 None
 0.90A 5iwuA-3c5oA:
1.5		 5iwuA-3c5oA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c5o UPF0311 PROTEIN
RPA1785

(Rhodopseudomonas
palustris) 		PF11578
(DUF3237) 		4 PHE A 119
VAL A  84
TYR A  72
ILE A 147
 None
 0.83A 5iwuA-3c5oA:
1.5		 5iwuA-3c5oA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d3u 4-HYDROXYBUTYRATE
COA-TRANSFERASE

(Porphyromonas
gingivalis) 		PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C) 		4 PHE A  62
VAL A 187
MET A 240
ILE A 217
 None
 0.97A 5iwuA-3d3uA:
undetectable		 5iwuA-3d3uA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e1k GALACTOSE/LACTOSE
METABOLISM
REGULATORY PROTEIN
GAL80

(Kluyveromyces
lactis) 		PF01408
(GFO_IDH_MocA) 		4 PHE A  22
VAL A  91
TYR A 120
ILE A 381
 None
 1.10A 5iwuA-3e1kA:
0.9		 5iwuA-3e1kA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3efy CIF (CELL CYCLE
INHIBITING FACTOR)

(Escherichia
coli) 		PF16374
(CIF) 		4 PHE A 260
VAL A 158
TYR A 167
ILE A 215
 None
 0.94A 5iwuA-3efyA:
undetectable		 5iwuA-3efyA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g8y SUSD/RAGB-ASSOCIATED
ESTERASE-LIKE
PROTEIN

(Bacteroides
vulgatus) 		PF12715
(Abhydrolase_7) 		4 PHE A 388
VAL A 393
TYR A 363
ASP A 279
 EDO  A   2 (-4.6A)
None
None
EDO  A   2 (-3.6A)
 0.99A 5iwuA-3g8yA:
undetectable		 5iwuA-3g8yA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hpe CONSERVED
HYPOTHETICAL
SECRETED PROTEIN

(Helicobacter
pylori) 		PF04264
(YceI) 		4 PHE A  64
TYR A 105
MET A 143
ILE A 129
 ERU  A 301 ( 4.5A)
None
None
None
 1.25A 5iwuA-3hpeA:
undetectable		 5iwuA-3hpeA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kkj AMINE OXIDASE,
FLAVIN-CONTAINING

(Pseudomonas
syringae group
genomosp. 3) 		PF01593
(Amino_oxidase)
PF13450
(NAD_binding_8) 		4 PHE A  65
VAL A 309
MET A 116
ILE A 112
 None
FAD  A 401 (-3.9A)
None
None
 1.22A 5iwuA-3kkjA:
undetectable		 5iwuA-3kkjA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ll8 CALCINEURIN SUBUNIT
B TYPE 1

(Homo sapiens) 		PF13499
(EF-hand_7) 		4 PHE B 152
VAL B 156
MET B 165
ILE B 161
 None
 1.15A 5iwuA-3ll8B:
undetectable		 5iwuA-3ll8B:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B

(Homo sapiens) 		PF00069
(Pkinase) 		4 PHE A 235
VAL A 252
TYR A 254
ILE A 270
 None
 1.24A 5iwuA-3lm5A:
5.3		 5iwuA-3lm5A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mjd OROTATE
PHOSPHORIBOSYLTRANSF
ERASE

(Francisella
tularensis) 		PF00156
(Pribosyltran) 		4 PHE A   2
VAL A 177
TYR A  47
ASP A 120
 None
 1.16A 5iwuA-3mjdA:
undetectable		 5iwuA-3mjdA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nuz PUTATIVE ACETYL
XYLAN ESTERASE

(Bacteroides
fragilis) 		PF12715
(Abhydrolase_7) 		4 PHE A 388
VAL A 393
TYR A 363
ASP A 279
 None
 1.08A 5iwuA-3nuzA:
undetectable		 5iwuA-3nuzA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o53 PROTEIN LRIM1

(Anopheles
gambiae) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		4 PHE A  79
VAL A  58
TYR A  34
ILE A  27
 None
 1.29A 5iwuA-3o53A:
undetectable		 5iwuA-3o53A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o65 PUTATIVE
ATAXIN-3-LIKE
PROTEIN

(Homo sapiens) 		PF02099
(Josephin) 		4 PHE A 113
VAL A 165
TYR A 100
ILE A 105
 None
 1.30A 5iwuA-3o65A:
undetectable		 5iwuA-3o65A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oja LEUCINE-RICH IMMUNE
MOLECULE 1

(Anopheles
gambiae) 		PF00560
(LRR_1) 		4 PHE A  79
VAL A  58
TYR A  34
ILE A  27
 None
 1.23A 5iwuA-3ojaA:
undetectable		 5iwuA-3ojaA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s30 HYPOTHETICAL
GLYCOSIDE HYDROLASE

(Bacteroides
vulgatus) 		PF13201
(PCMD) 		4 VAL A 350
TYR A 277
MET A 304
ILE A 294
 None
 1.20A 5iwuA-3s30A:
undetectable		 5iwuA-3s30A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tig TTL PROTEIN

(Xenopus
tropicalis) 		PF03133
(TTL) 		4 PHE A 315
VAL A 207
TYR A 211
ILE A 302
 None
 1.29A 5iwuA-3tigA:
undetectable		 5iwuA-3tigA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqo CYSTEINYL-TRNA
SYNTHETASE

(Coxiella
burnetii) 		PF01406
(tRNA-synt_1e)
PF09190
(DALR_2) 		4 PHE A  48
VAL A  51
ILE A   5
ASP A 349
 None
 0.97A 5iwuA-3tqoA:
undetectable		 5iwuA-3tqoA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vm5 ALPHA-AMYLASE

(Oryzias latipes) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C) 		4 PHE A 430
MET A 395
ILE A 454
ASP A 452
 None
 1.30A 5iwuA-3vm5A:
undetectable		 5iwuA-3vm5A:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a0k CULLIN-4A

(Homo sapiens) 		PF00888
(Cullin)
PF10557
(Cullin_Nedd8) 		4 TYR A 103
MET A 146
ILE A 170
ASP A 157
 None
 1.21A 5iwuA-4a0kA:
undetectable		 5iwuA-4a0kA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a64 CULLIN-4B

(Homo sapiens) 		PF00888
(Cullin) 		4 TYR A 239
MET A 282
ILE A 306
ASP A 293
 None
EDO  A1537 (-4.2A)
None
None
 1.26A 5iwuA-4a64A:
undetectable		 5iwuA-4a64A:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4as3 PHOSPHORYLCHOLINE
PHOSPHATASE

(Pseudomonas
aeruginosa) 		no annotation 4 PHE A 102
VAL A  98
TYR A  83
ASP A  40
 None
None
None
BTB  A1330 (-2.9A)
 1.31A 5iwuA-4as3A:
undetectable		 5iwuA-4as3A:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4azv WBDD

(Escherichia
coli) 		PF00069
(Pkinase)
PF13847
(Methyltransf_31) 		4 PHE A 245
VAL A 250
MET A 358
ILE A 368
 None
 0.93A 5iwuA-4azvA:
7.9		 5iwuA-4azvA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4azw WBDD

(Escherichia
coli) 		PF00069
(Pkinase)
PF13847
(Methyltransf_31) 		4 PHE A 245
VAL A 250
MET A 358
ILE A 368
 ATP  A1450 ( 4.9A)
ATP  A1450 ( 4.8A)
ATP  A1450 ( 4.2A)
ATP  A1450 (-4.2A)
 0.73A 5iwuA-4azwA:
7.8		 5iwuA-4azwA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b2o YMDB
PHOSPHODIESTERASE

(Bacillus
subtilis) 		PF13277
(YmdB) 		4 PHE A  78
VAL A  82
MET A  65
ILE A  63
 None
 0.90A 5iwuA-4b2oA:
undetectable		 5iwuA-4b2oA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c13 UDP-N-ACETYLMURAMOYL
-L-ALANYL-D-GLUTAMAT
E--L-LYSINE LIGASE

(Staphylococcus
aureus) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		4 PHE A 300
TYR A 259
MET A 120
ILE A 117
 None
 1.20A 5iwuA-4c13A:
undetectable		 5iwuA-4c13A:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d7e L-LYS MONOOXYGENASE

(Nocardia
farcinica) 		PF13434
(K_oxygenase) 		4 PHE A 194
VAL A 332
MET A 230
ILE A 233
 None
 1.15A 5iwuA-4d7eA:
undetectable		 5iwuA-4d7eA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4efi 3-OXOACYL-(ACYL-CARR
IER PROTEIN)
SYNTHASE

(Paraburkholderia
xenovorans) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		4 VAL A 336
MET A 164
ILE A 161
ASP A 159
 UNL  A 401 ( 4.9A)
None
None
None
 1.18A 5iwuA-4efiA:
undetectable		 5iwuA-4efiA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f67 UPF0176 PROTEIN
LPG2838

(Legionella
pneumophila) 		PF00581
(Rhodanese) 		4 PHE A   9
VAL A  45
MET A  29
ILE A  25
 None
 1.30A 5iwuA-4f67A:
undetectable		 5iwuA-4f67A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g09 HISTIDINOL
DEHYDROGENASE

(Brucella suis) 		PF00815
(Histidinol_dh) 		4 PHE A 277
VAL A 281
ILE A 241
ASP A 255
 None
 1.19A 5iwuA-4g09A:
undetectable		 5iwuA-4g09A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gqo LMO0859 PROTEIN

(Listeria
monocytogenes) 		PF13416
(SBP_bac_8) 		4 VAL A 322
TYR A 324
MET A  73
ILE A  83
 None
 1.11A 5iwuA-4gqoA:
undetectable		 5iwuA-4gqoA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gt6 CELL SURFACE PROTEIN

(Faecalibacterium
prausnitzii) 		PF13306
(LRR_5) 		4 PHE A 333
VAL A 332
MET A 298
ILE A 325
 None
 1.17A 5iwuA-4gt6A:
undetectable		 5iwuA-4gt6A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hjh PHOSPHOMANNOMUTASE

(Brucella
melitensis) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		4 PHE A 427
VAL A 433
TYR A 435
ILE A 466
 EDO  A 550 (-3.2A)
None
None
None
 1.13A 5iwuA-4hjhA:
undetectable		 5iwuA-4hjhA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hwt THREONINE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon) 		4 PHE A 523
VAL A 519
ILE A 393
ASP A 494
 None
 1.00A 5iwuA-4hwtA:
undetectable		 5iwuA-4hwtA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jjm PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Citrus sinensis) 		PF00160
(Pro_isomerase) 		4 PHE A 119
VAL A 121
MET A  10
ILE A  20
 None
 0.87A 5iwuA-4jjmA:
undetectable		 5iwuA-4jjmA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k29 ENOYL-COA
HYDRATASE/ISOMERASE

(Xanthobacter
autotrophicus) 		PF00378
(ECH_1) 		4 PHE A  61
VAL A  54
MET A  32
ILE A  36
 None
 1.14A 5iwuA-4k29A:
undetectable		 5iwuA-4k29A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nfu SENESCENCE-ASSOCIATE
D CARBOXYLESTERASE
101

(Arabidopsis
thaliana) 		PF01764
(Lipase_3) 		4 PHE B 219
VAL B 202
MET B 210
ILE B 208
 None
 1.25A 5iwuA-4nfuB:
undetectable		 5iwuA-4nfuB:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nmy ABC-TYPE TRANSPORT
SYSTEM,
EXTRACELLULAR
SOLUTE-BINDING
PROTEIN

(Clostridioides
difficile) 		PF09084
(NMT1) 		4 VAL A  84
MET A   8
ILE A  60
ASP A  11
 None
 0.89A 5iwuA-4nmyA:
undetectable		 5iwuA-4nmyA:
24.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oxp RIBONUCLEASE E

(Caulobacter
vibrioides) 		PF10150
(RNase_E_G) 		4 VAL A 150
TYR A  79
MET A 157
ILE A  74
 None
 1.28A 5iwuA-4oxpA:
undetectable		 5iwuA-4oxpA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rth MEMBRANE-EXTRINSIC
PROTEIN OF
PHOTOSYSTEM II PSBP

(Zea mays) 		PF01789
(PsbP) 		4 PHE A  80
VAL A  84
TYR A  86
ILE A  62
 None
 0.81A 5iwuA-4rthA:
2.1		 5iwuA-4rthA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uft NUCLEOPROTEIN

(Measles
morbillivirus) 		PF00973
(Paramyxo_ncap) 		4 PHE B  80
VAL B  81
ILE B  91
ASP B 239
 None
 1.12A 5iwuA-4uftB:
undetectable		 5iwuA-4uftB:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wb0 BROAD SPECIFICITY
AMINOTRANSFERASE

(Leishmania
mexicana) 		PF00155
(Aminotran_1_2) 		4 PHE A 242
VAL A 218
MET A 172
ILE A 176
 None
 1.19A 5iwuA-4wb0A:
undetectable		 5iwuA-4wb0A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x9t UNCHARACTERIZED
PROTEIN UPF0065

(Polaromonas sp.
JS666) 		PF03401
(TctC) 		4 PHE A 176
VAL A 152
MET A 221
ILE A 127
 None
 1.19A 5iwuA-4x9tA:
undetectable		 5iwuA-4x9tA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b2o CRISPR-ASSOCIATED
ENDONUCLEASE CAS9

(Francisella
tularensis) 		no annotation 4 PHE A 607
VAL A 611
TYR A 615
ASP A 549
 None
 1.15A 5iwuA-5b2oA:
2.1		 5iwuA-5b2oA:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c93 HISTIDINE KINASE

(Lactobacillus
plantarum) 		PF00512
(HisKA)
PF02518
(HATPase_c) 		4 PHE A 490
MET A 512
ILE A 486
ASP A 471
 None
 1.04A 5iwuA-5c93A:
undetectable		 5iwuA-5c93A:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ck0 SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 PHE A 249
TYR A 185
ILE A 163
ASP A 165
 None
 1.27A 5iwuA-5ck0A:
undetectable		 5iwuA-5ck0A:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dis SNURPORTIN-1

(Homo sapiens) 		PF11538
(Snurportin1) 		4 VAL C 122
TYR C 260
MET C 208
ASP C 173
 None
 1.05A 5iwuA-5disC:
undetectable		 5iwuA-5disC:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eh1 INTERFERON GAMMA
RECEPTOR 2

(Homo sapiens) 		PF01108
(Tissue_fac)
PF09294
(Interfer-bind) 		4 PHE A 132
VAL A 111
TYR A  69
ILE A  82
 None
 1.06A 5iwuA-5eh1A:
undetectable		 5iwuA-5eh1A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5esx PURINE/PYRIMIDINE
PHOSPHORIBOSYLTRANSF
ERASE

(Legionella
pneumophila) 		PF00156
(Pribosyltran) 		4 VAL A 156
MET A 166
ILE A 107
ASP A 109
 None
None
5GP  A 600 (-4.2A)
5GP  A 600 (-4.0A)
 1.15A 5iwuA-5esxA:
undetectable		 5iwuA-5esxA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fta BTB/POZ
DOMAIN-CONTAINING
ADAPTER FOR
CUL3-MEDIATED RHOA
DEGRADATION PROTEIN
3

(Homo sapiens) 		PF02214
(BTB_2) 		4 PHE A  84
VAL A  38
MET A  60
ILE A  75
 None
 1.00A 5iwuA-5ftaA:
undetectable		 5iwuA-5ftaA:
16.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5igu MACROLIDE
2'-PHOSPHOTRANSFERAS
E II

(Escherichia
coli) 		PF01636
(APH) 		5 PHE A  37
VAL A  47
TYR A  92
MET A 207
ILE A 218
 None
 0.60A 5iwuA-5iguA:
31.5		 5iwuA-5iguA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5koh NITROGENASE FEMO
BETA SUBUNIT PROTEIN
NIFK

(Gluconacetobacter
diazotrophicus) 		PF00148
(Oxidored_nitro)
PF11844
(DUF3364) 		4 PHE B  81
VAL B  77
TYR B 196
ILE B 222
 None
 1.20A 5iwuA-5kohB:
undetectable		 5iwuA-5kohB:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m5x DNA-DIRECTED RNA
POLYMERASE I SUBUNIT
RPA135

(Saccharomyces
cerevisiae) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF06883
(RNA_pol_Rpa2_4) 		4 VAL B1031
MET B 787
ILE B 947
ASP B 946
 None
 0.96A 5iwuA-5m5xB:
undetectable		 5iwuA-5m5xB:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mju EXCITATORY AMINO
ACID TRANSPORTER
1,NEUTRAL AMINO ACID
TRANSPORTER
B(0),EXCITATORY
AMINO ACID
TRANSPORTER 1

(Homo sapiens) 		PF00375
(SDF) 		4 VAL A 301
TYR A 297
MET A 431
ASP A 452
 None
 1.26A 5iwuA-5mjuA:
undetectable		 5iwuA-5mjuA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5pep PEPSIN

(Sus scrofa) 		PF00026
(Asp) 		4 PHE A 314
VAL A 153
ILE A 307
ASP A 304
 None
 1.29A 5iwuA-5pepA:
undetectable		 5iwuA-5pepA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sva MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 4
MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 9

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF10018
(Med4)
PF07544
(Med9) 		4 PHE T  81
TYR T  49
ILE V  76
ASP V  79
 None
 1.26A 5iwuA-5svaT:
undetectable		 5iwuA-5svaT:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tj5 V-TYPE PROTON ATPASE
SUBUNIT C'
V-TYPE PROTON ATPASE
SUBUNIT C

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF00137
(ATP-synt_C)
PF00137
(ATP-synt_C) 		4 PHE D 143
VAL D 146
TYR D 150
ILE E  65
 None
 1.22A 5iwuA-5tj5D:
undetectable		 5iwuA-5tj5D:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tum TETRACYCLINE
DESTRUCTASE TET(56)

(Legionella
longbeachae) 		PF01494
(FAD_binding_3) 		4 VAL A 152
MET A 165
ILE A 162
ASP A 156
 None
None
None
FAD  A 401 (-3.8A)
 1.19A 5iwuA-5tumA:
undetectable		 5iwuA-5tumA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w1a MYOSIN HEAVY CHAIN,
MUSCLE

(Drosophila
melanogaster) 		no annotation 4 PHE A 609
VAL A 605
MET A 361
ILE A 423
 None
 0.94A 5iwuA-5w1aA:
undetectable		 5iwuA-5w1aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wgx FLAVIN-DEPENDENT
HALOGENASE

(Malbranchea
aurantiaca) 		PF04820
(Trp_halogenase) 		4 VAL A 500
TYR A 508
MET A 416
ILE A  86
 None
 1.29A 5iwuA-5wgxA:
undetectable		 5iwuA-5wgxA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xag TUBULIN TYROSINE
LIGASE

(Gallus gallus) 		no annotation 4 PHE F 315
VAL F 207
TYR F 211
ILE F 302
 None
 1.30A 5iwuA-5xagF:
undetectable		 5iwuA-5xagF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xog SPT4/5 COMPLEX
COMPONENT

(Komagataella
phaffii) 		PF00467
(KOW) 		4 PHE W 778
VAL W 770
ILE W 798
ASP W 809
 None
 1.20A 5iwuA-5xogW:
undetectable		 5iwuA-5xogW:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xon PROTEIN THAT FORMS A
COMPLEX WITH SPT4P

(Komagataella
phaffii) 		PF00467
(KOW)
PF03439
(Spt5-NGN) 		4 PHE W 778
VAL W 770
ILE W 798
ASP W 809
 None
 1.20A 5iwuA-5xonW:
undetectable		 5iwuA-5xonW:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zya SPLICING FACTOR 3B
SUBUNIT 1

(Homo sapiens) 		no annotation 4 PHE C 647
VAL C 651
ILE C 617
ASP C 618
 None
 1.17A 5iwuA-5zyaC:
undetectable		 5iwuA-5zyaC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b4c -

(-) 		no annotation 4 VAL A 194
TYR A 292
ILE A 137
ASP A 127
 None
 1.27A 5iwuA-6b4cA:
undetectable		 5iwuA-6b4cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE

(Medicago
truncatula) 		no annotation 4 PHE A 329
VAL A 312
ILE A 297
ASP A 304
 None
 1.08A 5iwuA-6cczA:
undetectable		 5iwuA-6cczA:
undetectable