SIMILAR PATTERNS OF AMINO ACIDS FOR 5ITZ_B_LOCB502

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d2r PROTEIN
(TRYPTOPHANYL TRNA
SYNTHETASE)


(Geobacillus
stearothermophilus)
PF00579
(tRNA-synt_1b)
5 LEU A 272
ALA A 220
MET A 193
ILE A 213
ILE A  16
None
1.11A 5itzB-1d2rA:
undetectable
5itzB-1d2rA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dt2 EXFOLIATIVE TOXIN B

(Staphylococcus
aureus)
PF13365
(Trypsin_2)
5 LEU A 234
LEU A 115
ASN A  63
ILE A  55
ILE A 117
None
1.06A 5itzB-1dt2A:
0.0
5itzB-1dt2A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ej6 LAMBDA1

(Reovirus sp.)
no annotation 5 LEU B 595
ALA B 815
LEU B 549
ALA B 885
ILE B 551
None
1.07A 5itzB-1ej6B:
0.0
5itzB-1ej6B:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g61 TRANSLATION
INITIATION FACTOR 6


(Methanocaldococcus
jannaschii)
PF01912
(eIF-6)
5 LEU A2020
LEU A2107
LEU A2070
ILE A2053
ILE A2084
None
0.93A 5itzB-1g61A:
undetectable
5itzB-1g61A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gyt CYTOSOL
AMINOPEPTIDASE


(Escherichia
coli)
PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N)
5 LEU A 488
LEU A 493
ASN A 495
ILE A 375
ILE A 265
None
1.06A 5itzB-1gytA:
2.0
5itzB-1gytA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h6u INTERNALIN H

(Listeria
monocytogenes)
PF08191
(LRR_adjacent)
PF12354
(Internalin_N)
PF12799
(LRR_4)
PF13516
(LRR_6)
5 LEU A 103
ALA A  83
LEU A  53
ILE A  78
LYS A  58
None
0.97A 5itzB-1h6uA:
0.3
5itzB-1h6uA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1htd ATROLYSIN C

(Crotalus atrox)
PF01421
(Reprolysin)
5 LEU A  47
LEU A 148
ASN A 147
MET A 116
ILE A 198
None
1.01A 5itzB-1htdA:
1.0
5itzB-1htdA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1izo CYTOCHROME P450
152A1


(Bacillus
subtilis)
PF00067
(p450)
5 LEU A 241
LEU A 102
LEU A 214
ALA A 218
ILE A 198
None
1.06A 5itzB-1izoA:
undetectable
5itzB-1izoA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ko0 DIAMINOPIMELATE
DECARBOXYLASE


(Escherichia
coli)
PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N)
5 LEU A 175
LEU A 127
LEU A 185
ILE A 166
ILE A 188
None
1.02A 5itzB-1ko0A:
1.2
5itzB-1ko0A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lvl DIHYDROLIPOAMIDE
DEHYDROGENASE


(Pseudomonas
putida)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
5 LEU A   8
LEU A  33
ALA A  21
ALA A 141
ILE A  11
None
None
None
FAD  A 459 (-4.5A)
FAD  A 459 (-4.5A)
1.06A 5itzB-1lvlA:
undetectable
5itzB-1lvlA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6z CHIMERA OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND ARGONAUTE 2


(Drosophila
melanogaster;
Escherichia
coli)
no annotation 5 LEU P 659
ASN P 622
THR P 620
ILE P 710
ILE P 617
None
1.05A 5itzB-1r6zP:
undetectable
5itzB-1r6zP:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1soj CGMP-INHIBITED
3',5'-CYCLIC
PHOSPHODIESTERASE B


(Homo sapiens)
PF00233
(PDEase_I)
5 CYH A 929
LEU A 926
ALA A 889
LEU A 885
ILE A 806
None
1.08A 5itzB-1sojA:
undetectable
5itzB-1sojA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v9k RIBOSOMAL LARGE
SUBUNIT
PSEUDOURIDINE
SYNTHASE C


(Escherichia
coli)
PF00849
(PseudoU_synth_2)
5 LEU A 137
LEU A 139
LEU A 127
LYS A 107
ILE A  95
None
1.04A 5itzB-1v9kA:
undetectable
5itzB-1v9kA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w99 PESTICIDIAL CRYSTAL
PROTEIN CRY4BA


(Bacillus
thuringiensis)
PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N)
5 LEU A 517
LEU A 511
ALA A 495
THR A 609
ALA A 611
None
0.93A 5itzB-1w99A:
undetectable
5itzB-1w99A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wni TRIMERELYSIN II

(Protobothrops
flavoviridis)
PF01421
(Reprolysin)
5 LEU A  47
LEU A 148
ASN A 147
MET A 116
ILE A 197
None
1.06A 5itzB-1wniA:
undetectable
5itzB-1wniA:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yp1 FII

(Deinagkistrodon
acutus)
PF01421
(Reprolysin)
5 LEU A  47
LEU A 148
ASN A 147
MET A 116
ILE A 197
None
0.98A 5itzB-1yp1A:
undetectable
5itzB-1yp1A:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2buc DIPEPTIDYL PEPTIDASE
IV


(Sus scrofa)
PF00326
(Peptidase_S9)
PF00930
(DPPIV_N)
5 LEU A 410
LEU A 436
ASN A 437
LYS A 441
ILE A 397
None
0.99A 5itzB-2bucA:
undetectable
5itzB-2bucA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fur HYPOTHETICAL PROTEIN

(Thermoplasma
acidophilum)
PF12900
(Pyridox_ox_2)
5 ALA A  26
LEU A  28
ASN A  31
ALA A 104
ILE A 106
None
1.09A 5itzB-2furA:
undetectable
5itzB-2furA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gu0 NONSTRUCTURAL
PROTEIN 2


(Rotavirus C)
PF02509
(Rota_NS35)
5 LEU A  83
LEU A 142
ASN A 141
LYS A   2
ILE A 101
None
1.08A 5itzB-2gu0A:
undetectable
5itzB-2gu0A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h3l LAP2 PROTEIN

(Homo sapiens)
PF00595
(PDZ)
5 LEU A1369
LEU A1332
LEU A1404
ASN A1379
ILE A1336
None
1.00A 5itzB-2h3lA:
undetectable
5itzB-2h3lA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hyj PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR


(Streptomyces
coelicolor)
PF00440
(TetR_N)
5 LEU A  86
ALA A 147
LEU A 144
ALA A 196
ILE A 166
None
1.11A 5itzB-2hyjA:
undetectable
5itzB-2hyjA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j8k NP275-NP276

(Nostoc
punctiforme)
PF00805
(Pentapeptide)
5 LEU A  92
LEU A 132
ALA A 130
LEU A 107
ILE A 117
None
0.98A 5itzB-2j8kA:
undetectable
5itzB-2j8kA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j8k NP275-NP276

(Nostoc
punctiforme)
PF00805
(Pentapeptide)
5 LEU A 112
LEU A 152
ALA A 150
LEU A 127
ASN A 146
None
1.10A 5itzB-2j8kA:
undetectable
5itzB-2j8kA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jjy ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE


(Francisella
tularensis)
PF13561
(adh_short_C2)
5 LEU A 144
THR A  12
ALA A  21
ILE A 222
ILE A  24
None
0.99A 5itzB-2jjyA:
7.4
5itzB-2jjyA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2krs PROBABLE ENTEROTOXIN

(Clostridium
perfringens)
PF08239
(SH3_3)
5 LEU A  27
ASN A  12
ALA A  54
ILE A  59
ILE A  45
None
1.06A 5itzB-2krsA:
undetectable
5itzB-2krsA:
10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1s 1-DEOXY-D-XYLULOSE-5
-PHOSPHATE SYNTHASE


(Escherichia
coli)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C)
PF13292
(DXP_synthase_N)
5 LEU A 242
ASN A 165
ALA A 160
ILE A 155
ILE A 127
None
0.97A 5itzB-2o1sA:
undetectable
5itzB-2o1sA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p91 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]


(Aquifex
aeolicus)
PF13561
(adh_short_C2)
5 LEU A 159
THR A  27
ALA A  36
ILE A 237
ILE A  39
None
0.90A 5itzB-2p91A:
7.4
5itzB-2p91A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pnn TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 1


(Rattus
norvegicus)
PF12796
(Ank_2)
5 LEU A 268
ALA A 275
THR A 258
ALA A 256
ILE A 312
LEU  A 268 ( 0.6A)
ALA  A 275 ( 0.0A)
THR  A 258 ( 0.8A)
ALA  A 256 ( 0.0A)
ILE  A 312 ( 0.7A)
1.03A 5itzB-2pnnA:
1.5
5itzB-2pnnA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v7b BENZOATE-COENZYME A
LIGASE


(Paraburkholderia
xenovorans)
PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
5 LEU A 167
ALA A  64
LEU A  65
ALA A 123
ILE A 125
None
1.04A 5itzB-2v7bA:
undetectable
5itzB-2v7bA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vbi PYRUVATE
DECARBOXYLASE


(Acetobacter
pasteurianus)
PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
5 LEU A 206
ALA A 335
LEU A 232
ILE A 305
ILE A 283
None
0.90A 5itzB-2vbiA:
undetectable
5itzB-2vbiA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vz9 FATTY ACID SYNTHASE

(Sus scrofa)
PF00107
(ADH_zinc_N)
PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF08242
(Methyltransf_12)
PF08659
(KR)
PF14765
(PS-DH)
PF16197
(KAsynt_C_assoc)
5 LEU A1022
ALA A1034
LEU A1032
ALA A1094
ILE A1059
None
1.05A 5itzB-2vz9A:
undetectable
5itzB-2vz9A:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w2k D-MANDELATE
DEHYDROGENASE


(Rhodotorula
graminis)
PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C)
5 CYH B 223
THR B 117
ALA B 121
ILE B 125
ILE B 178
None
1.02A 5itzB-2w2kB:
undetectable
5itzB-2w2kB:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w3p BENZOYL-COA-DIHYDROD
IOL LYASE


(Paraburkholderia
xenovorans)
PF00378
(ECH_1)
5 LEU A 368
ALA A 398
LEU A 395
THR A 280
ILE A 317
None
1.07A 5itzB-2w3pA:
undetectable
5itzB-2w3pA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b59 GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE


(Novosphingobium
aromaticivorans)
PF00903
(Glyoxalase)
5 ALA A 188
LEU A 147
ASN A 197
ILE A   9
ILE A  68
None
1.01A 5itzB-3b59A:
undetectable
5itzB-3b59A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cgi PROPANEDIOL
UTILIZATION PROTEIN
PDUU


(Salmonella
enterica)
PF00936
(BMC)
5 LEU A  84
ALA A  64
THR A 110
ALA A  23
ILE A 113
None
1.08A 5itzB-3cgiA:
undetectable
5itzB-3cgiA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmv PROTEIN RECA

(Escherichia
coli)
PF00154
(RecA)
5 LEU A 178
ALA A 131
THR A  89
ALA A  91
ILE A  93
None
1.12A 5itzB-3cmvA:
undetectable
5itzB-3cmvA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cz8 PUTATIVE
SPORULATION-SPECIFIC
GLYCOSYLASE YDHD


(Bacillus
subtilis)
PF00704
(Glyco_hydro_18)
5 LEU A 182
ALA A 187
LEU A 191
ASN A 194
ILE A 177
None
1.11A 5itzB-3cz8A:
undetectable
5itzB-3cz8A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d8h GLYCOLYTIC
PHOSPHOGLYCERATE
MUTASE


(Cryptosporidium
parvum)
PF00300
(His_Phos_1)
5 LEU A 197
LEU A 104
ALA A 200
LEU A  25
ILE A 186
None
1.08A 5itzB-3d8hA:
undetectable
5itzB-3d8hA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fxi TOLL-LIKE RECEPTOR 4

(Homo sapiens)
PF13516
(LRR_6)
PF13855
(LRR_8)
5 LEU A 231
LEU A 180
LEU A 210
ASN A 185
ILE A 190
None
1.11A 5itzB-3fxiA:
undetectable
5itzB-3fxiA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fxi TOLL-LIKE RECEPTOR 4

(Homo sapiens)
PF13516
(LRR_6)
PF13855
(LRR_8)
5 LEU A 258
LEU A 208
ASN A 213
MET A 215
ILE A 218
None
1.01A 5itzB-3fxiA:
undetectable
5itzB-3fxiA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g2e OORC SUBUNIT OF
2-OXOGLUTARATE:ACCEP
TOR OXIDOREDUCTASE


(Campylobacter
jejuni)
PF01558
(POR)
5 LEU A  73
ALA A  18
ALA A 121
ILE A 118
ILE A 120
None
1.10A 5itzB-3g2eA:
3.1
5itzB-3g2eA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g85 TRANSCRIPTIONAL
REGULATOR (LACI
FAMILY)


(Clostridium
acetobutylicum)
PF13377
(Peripla_BP_3)
5 CYH A 248
LEU A 246
ALA A 185
ALA A 232
ILE A 253
None
1.10A 5itzB-3g85A:
4.0
5itzB-3g85A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3goz LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN


(Legionella
pneumophila)
no annotation 5 LEU A  71
LEU A  58
ASN A  57
ILE A 107
ILE A  78
None
1.08A 5itzB-3gozA:
undetectable
5itzB-3gozA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oc4 OXIDOREDUCTASE,
PYRIDINE
NUCLEOTIDE-DISULFIDE
FAMILY


(Enterococcus
faecalis)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
6 LEU A  -1
LEU A 309
ASN A 307
ALA A  15
ILE A  28
ILE A 106
None
1.32A 5itzB-3oc4A:
undetectable
5itzB-3oc4A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pr2 TRYPTOPHAN SYNTHASE
BETA CHAIN


(Salmonella
enterica)
PF00291
(PALP)
5 LEU B 271
ALA B 284
THR B 199
ALA B 191
ILE B 238
None
0.98A 5itzB-3pr2B:
undetectable
5itzB-3pr2B:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rg1 CD180 MOLECULE

(Bos taurus)
PF00560
(LRR_1)
PF13855
(LRR_8)
5 LEU A 525
LEU A 498
LEU A 503
THR A 459
ILE A 486
None
1.10A 5itzB-3rg1A:
undetectable
5itzB-3rg1A:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3si9 DIHYDRODIPICOLINATE
SYNTHASE


(Bartonella
henselae)
PF00701
(DHDPS)
5 ALA A 293
LEU A 244
ALA A 260
LYS A 263
ILE A 257
None
0.99A 5itzB-3si9A:
undetectable
5itzB-3si9A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sz3 TRYPTOPHANYL-TRNA
SYNTHETASE


(Vibrio cholerae)
PF00579
(tRNA-synt_1b)
5 ALA A 226
ASN A 208
MET A 199
ILE A 219
ILE A  18
None
1.08A 5itzB-3sz3A:
undetectable
5itzB-3sz3A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6q CD180 ANTIGEN

(Mus musculus)
PF13855
(LRR_8)
5 LEU A 377
LEU A 395
LEU A 350
ALA A 341
ILE A 339
None
1.03A 5itzB-3t6qA:
undetectable
5itzB-3t6qA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3twk FORMAMIDOPYRIMIDINE-
DNA GLYCOSYLASE 1


(Arabidopsis
thaliana)
PF01149
(Fapy_DNA_glyco)
PF06831
(H2TH)
5 CYH A  18
LEU A  19
LEU A 114
LEU A  64
ILE A  84
None
1.07A 5itzB-3twkA:
undetectable
5itzB-3twkA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v2h D-BETA-HYDROXYBUTYRA
TE DEHYDROGENASE


(Sinorhizobium
meliloti)
PF13561
(adh_short_C2)
5 LEU A  22
MET A   0
ALA A 237
ILE A 136
ILE A  84
None
0.99A 5itzB-3v2hA:
7.2
5itzB-3v2hA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w4k D-AMINO-ACID OXIDASE

(Homo sapiens)
PF01266
(DAO)
5 LEU A 291
ALA A 327
ILE A 306
LYS A 328
ILE A  19
None
1.09A 5itzB-3w4kA:
3.6
5itzB-3w4kA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyn LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4B


(Mus musculus)
PF00560
(LRR_1)
PF13855
(LRR_8)
5 LEU A 284
LEU A 236
LEU A 262
ASN A 241
ILE A 246
None
1.06A 5itzB-3zynA:
undetectable
5itzB-3zynA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bla MALTOSE-BINDING
PERIPLASMIC PROTEIN,
SUPPRESSOR OF FUSED
HOMOLOG


(Escherichia
coli;
Homo sapiens)
PF05076
(SUFU)
PF12470
(SUFU_C)
PF13416
(SBP_bac_8)
5 LEU A 116
LEU A 123
ASN A 119
ALA A 147
ILE A 133
None
1.05A 5itzB-4blaA:
undetectable
5itzB-4blaA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ecd CHORISMATE SYNTHASE

(Bifidobacterium
longum)
PF01264
(Chorismate_synt)
5 LEU A 361
ALA A 357
ALA A  17
ILE A  19
ILE A  75
None
0.80A 5itzB-4ecdA:
undetectable
5itzB-4ecdA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ew6 D-GALACTOSE-1-DEHYDR
OGENASE PROTEIN


(Rhizobium etli)
PF01408
(GFO_IDH_MocA)
5 LEU A  65
ALA A  75
MET A  53
ALA A   7
ILE A  60
None
1.12A 5itzB-4ew6A:
3.7
5itzB-4ew6A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fho INTERNALIN C2

(Listeria
monocytogenes)
PF12354
(Internalin_N)
PF12799
(LRR_4)
PF13516
(LRR_6)
5 LEU A 103
ALA A  83
LEU A  53
ILE A  78
LYS A  58
None
1.01A 5itzB-4fhoA:
undetectable
5itzB-4fhoA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gyi RIO2 KINASE

(Chaetomium
thermophilum)
PF01163
(RIO1)
PF09202
(Rio2_N)
5 LEU A  76
LEU A  57
ALA A  41
ILE A  37
ILE A  40
None
1.06A 5itzB-4gyiA:
undetectable
5itzB-4gyiA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i2w PROTEIN UNC-45

(Caenorhabditis
elegans)
PF11701
(UNC45-central)
5 LEU A 753
LEU A 799
THR A 812
ILE A 770
ILE A 776
None
1.10A 5itzB-4i2wA:
undetectable
5itzB-4i2wA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4itu SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR


(Xanthobacter
autotrophicus)
PF13561
(adh_short_C2)
5 LEU A  88
ALA A 126
ALA A  35
ILE A  10
ILE A  82
None
1.09A 5itzB-4ituA:
6.7
5itzB-4ituA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j4m ZINC-DEPENDENT
METALLOPROTEINASE


(Protobothrops
mucrosquamatus)
PF01421
(Reprolysin)
5 LEU A  49
LEU A 150
ASN A 149
MET A 118
ILE A 199
None
1.06A 5itzB-4j4mA:
undetectable
5itzB-4j4mA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jej GERANYLGERANYLGLYCER
YL PHOSPHATE
SYNTHASE


(Flavobacterium
johnsoniae)
PF01884
(PcrB)
5 ALA A  96
LEU A  98
ILE A  13
LYS A 175
ILE A 206
None
1.12A 5itzB-4jejA:
undetectable
5itzB-4jejA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jx8 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH] FABI


(Escherichia
coli)
PF13561
(adh_short_C2)
5 LEU A 144
THR A  12
ALA A  21
ILE A 222
ILE A  24
NAD  A 302 (-3.9A)
None
None
None
None
0.88A 5itzB-4jx8A:
7.0
5itzB-4jx8A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lix ENT-COPALYL
DIPHOSPHATE
SYNTHASE,
CHLOROPLASTIC


(Arabidopsis
thaliana)
PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C)
5 LEU A 125
ALA A 121
ALA A 221
ILE A 224
ILE A 226
None
0.98A 5itzB-4lixA:
undetectable
5itzB-4lixA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q6j LMO0131 PROTEIN

(Listeria
monocytogenes)
PF00563
(EAL)
5 LEU A  60
ALA A  62
ASN A  15
ALA A  11
ILE A   8
None
1.12A 5itzB-4q6jA:
undetectable
5itzB-4q6jA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qjy GH127
BETA-L-ARABINOFURANO
SIDASE


(Geobacillus
stearothermophilus)
PF07944
(Glyco_hydro_127)
5 LEU A 207
ASN A 203
ALA A 165
ILE A 142
ILE A 168
None
1.05A 5itzB-4qjyA:
undetectable
5itzB-4qjyA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r7z CELL DIVISION
CONTROL PROTEIN 21


(Pyrococcus
furiosus)
PF00493
(MCM)
5 LEU A 757
ALA A 348
LEU A 344
ASN A 343
ILE A 300
None
1.10A 5itzB-4r7zA:
undetectable
5itzB-4r7zA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u06 LIC10831

(Leptospira
interrogans)
PF12799
(LRR_4)
PF13855
(LRR_8)
5 LEU A 350
LEU A 304
LEU A 329
ASN A 309
ILE A 318
None
1.07A 5itzB-4u06A:
undetectable
5itzB-4u06A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u3t PENICILLIN-BINDING
PROTEIN 2


(Neisseria
gonorrhoeae)
PF00905
(Transpeptidase)
5 LEU A 447
THR A 534
ALA A 532
ILE A 530
ILE A 519
None
0.86A 5itzB-4u3tA:
undetectable
5itzB-4u3tA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wpg DTDP-4-DEHYDRORHAMNO
SE REDUCTASE


(Streptococcus
pyogenes)
PF04321
(RmlD_sub_bind)
5 LEU A  18
LEU A  11
THR A  95
ILE A   4
ILE A   2
None
None
MRD  A 302 (-2.9A)
None
None
1.09A 5itzB-4wpgA:
6.4
5itzB-4wpgA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wrn MALTOSE-BINDING
PERIPLASMIC
PROTEIN,UROMODULIN


(Escherichia
coli;
Homo sapiens)
PF00100
(Zona_pellucida)
PF13416
(SBP_bac_8)
5 LEU A 139
LEU A 146
ASN A 142
ALA A 170
ILE A 156
None
1.08A 5itzB-4wrnA:
undetectable
5itzB-4wrnA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wrn MALTOSE-BINDING
PERIPLASMIC
PROTEIN,UROMODULIN


(Escherichia
coli;
Homo sapiens)
PF00100
(Zona_pellucida)
PF13416
(SBP_bac_8)
5 LEU A 163
LEU A 146
ASN A 148
ILE A 156
LYS A 151
None
1.11A 5itzB-4wrnA:
undetectable
5itzB-4wrnA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x8i LYSYL AMINOPEPTIDASE

(Pyrococcus
furiosus)
PF05343
(Peptidase_M42)
5 LEU A 278
ALA A 271
LEU A 335
ALA A 304
ILE A 227
None
1.10A 5itzB-4x8iA:
3.7
5itzB-4x8iA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yei BETA1MUT

(synthetic
construct)
PF00805
(Pentapeptide)
5 LEU A  97
LEU A 137
ALA A 135
LEU A 112
ASN A 131
None
1.12A 5itzB-4yeiA:
undetectable
5itzB-4yeiA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yei BETA1MUT

(synthetic
construct)
PF00805
(Pentapeptide)
5 LEU A 127
LEU A 167
ALA A 165
LEU A 142
ASN A 161
None
1.08A 5itzB-4yeiA:
undetectable
5itzB-4yeiA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a9b POLYHEDRIN

(Cypovirus 1)
PF05865
(Cypo_polyhedrin)
5 LEU A 168
LEU A 177
MET A 124
THR A 146
ILE A 111
None
1.09A 5itzB-5a9bA:
undetectable
5itzB-5a9bA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a9p POLYHEDRIN

(Operophtera
brumata
cypovirus 18)
PF05865
(Cypo_polyhedrin)
5 LEU A 168
LEU A 177
MET A 124
THR A 146
ILE A 111
None
1.06A 5itzB-5a9pA:
undetectable
5itzB-5a9pA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c2z EXFOLIATIVE TOXIN D2

(Staphylococcus
aureus)
PF00089
(Trypsin)
5 LEU A 266
LEU A 146
ASN A  94
ILE A  86
ILE A 148
None
1.01A 5itzB-5c2zA:
undetectable
5itzB-5c2zA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c77 PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1


(Saccharomyces
cerevisiae)
PF04252
(RNA_Me_trans)
5 LEU A 128
ALA A 123
LEU A  62
THR A  58
ILE A   4
None
1.11A 5itzB-5c77A:
undetectable
5itzB-5c77A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cyr RNA-DEPENDENT RNA
POLYMERASE


(Thosea asigna
virus)
no annotation 5 LEU B 517
LEU B 513
LEU B 329
MET B 307
ALA B 347
None
1.10A 5itzB-5cyrB:
undetectable
5itzB-5cyrB:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fmg PROTEASOME SUBUNIT
ALPHA TYPE


(Plasmodium
falciparum)
PF00227
(Proteasome)
PF10584
(Proteasome_A_N)
5 LEU C 212
LEU C  37
THR C 170
ALA C 163
ILE C  33
None
1.08A 5itzB-5fmgC:
undetectable
5itzB-5fmgC:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gmh TOLL-LIKE RECEPTOR 7

(Macaca mulatta)
PF00560
(LRR_1)
PF13306
(LRR_5)
PF13855
(LRR_8)
5 LEU A 547
LEU A 498
LEU A 524
ASN A 503
ILE A 508
None
1.12A 5itzB-5gmhA:
undetectable
5itzB-5gmhA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gr8 LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE PEPR1


(Arabidopsis
thaliana)
PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8)
5 CYH A 338
LEU A 362
LEU A 317
LEU A 344
ILE A 331
None
0.98A 5itzB-5gr8A:
undetectable
5itzB-5gr8A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hz1 PROBABLE LRR
RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE
AT4G26540


(Arabidopsis
thaliana)
PF13855
(LRR_8)
5 CYH B 357
LEU B 381
LEU B 336
LEU B 363
ILE B 350
None
1.09A 5itzB-5hz1B:
undetectable
5itzB-5hz1B:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jqe SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN,CASPASE-8
CHIMERA


(Escherichia
coli)
PF01335
(DED)
PF13416
(SBP_bac_8)
5 LEU A 151
LEU A 134
THR A 257
ILE A 144
LYS A 139
None
1.07A 5itzB-5jqeA:
undetectable
5itzB-5jqeA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ksh PENICILLIN-BINDING
PROTEIN 2


(Neisseria
gonorrhoeae)
PF00905
(Transpeptidase)
PF03717
(PBP_dimer)
5 LEU A 447
THR A 534
ALA A 532
ILE A 530
ILE A 519
None
0.82A 5itzB-5kshA:
undetectable
5itzB-5kshA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kzm TRYPTOPHAN SYNTHASE
BETA CHAIN


(Francisella
tularensis)
PF00291
(PALP)
5 LEU B 270
ALA B 283
THR B 198
ALA B 190
ILE B 237
None
1.03A 5itzB-5kzmB:
undetectable
5itzB-5kzmB:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5la0 CARBOHYDRATE BINDING
FAMILY 6


(Ruminiclostridium
thermocellum)
PF00150
(Cellulase)
PF03422
(CBM_6)
5 LEU A 490
LEU A 445
ASN A 444
ILE A 435
ILE A 511
None
1.09A 5itzB-5la0A:
undetectable
5itzB-5la0A:
22.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mjs TUBULIN BETA CHAIN

(Schizosaccharomyces
pombe)
no annotation 5 LEU A 253
MET A 257
THR A 311
ALA A 313
ILE A 367
None
1.03A 5itzB-5mjsA:
53.3
5itzB-5mjsA:
58.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mp7 RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE


(Mycolicibacterium
smegmatis)
PF13793
(Pribosyltran_N)
PF14572
(Pribosyl_synth)
5 LEU A 192
THR A 259
ALA A 257
ILE A 255
ILE A 280
None
1.06A 5itzB-5mp7A:
undetectable
5itzB-5mp7A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n3u PHYCOCYANOBILIN
LYASE SUBUNIT ALPHA


(Nostoc sp. PCC
7120)
no annotation 5 LEU A  81
ALA A  80
LEU A  41
ALA A  54
ILE A  23
None
1.08A 5itzB-5n3uA:
undetectable
5itzB-5n3uA:
11.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n5n TUBULIN BETA CHAIN

(Homo sapiens)
no annotation 5 LEU B 255
ASN B 258
MET B 259
THR B 314
ILE B 378
None
0.88A 5itzB-5n5nB:
53.4
5itzB-5n5nB:
97.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n5n TUBULIN BETA CHAIN

(Homo sapiens)
no annotation 5 LEU B 255
MET B 259
THR B 314
ALA B 316
ILE B 378
None
0.99A 5itzB-5n5nB:
53.4
5itzB-5n5nB:
97.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oak BAZOOKA, ISOFORM
C,LD29223P


(Drosophila
melanogaster)
no annotation 5 LEU A  84
LEU A  49
ALA A  44
ALA A  23
ILE A  55
None
1.07A 5itzB-5oakA:
undetectable
5itzB-5oakA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t0v IRON SULFUR CLUSTER
ASSEMBLY PROTEIN 1,
MITOCHONDRIAL


(Saccharomyces
cerevisiae)
PF01491
(Frataxin_Cyay)
5 ALA a 150
LEU a  75
MET a  73
ALA a 143
ILE a 121
None
1.09A 5itzB-5t0va:
undetectable
5itzB-5t0va:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vkq NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L


(Drosophila
melanogaster)
PF00023
(Ank)
PF00520
(Ion_trans)
PF12796
(Ank_2)
PF13637
(Ank_4)
5 LEU A 981
LEU A 979
ALA A 983
LEU A1016
ILE A1007
None
1.11A 5itzB-5vkqA:
undetectable
5itzB-5vkqA:
13.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5w3j TUBULIN BETA CHAIN

(Saccharomyces
cerevisiae)
PF00091
(Tubulin)
PF03953
(Tubulin_C)
5 LEU B 253
ASN B 256
THR B 312
ALA B 314
ILE B 368
None
0.81A 5itzB-5w3jB:
53.4
5itzB-5w3jB:
75.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z67 DNA REPLICATION AND
REPAIR PROTEIN RECF


(Caldanaerobacter
subterraneus)
no annotation 5 LEU A 137
LEU A 204
MET A 208
ILE A 125
ILE A 271
None
1.12A 5itzB-5z67A:
undetectable
5itzB-5z67A:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c1d UNCONVENTIONAL
MYOSIN-IB


(Rattus
norvegicus)
no annotation 6 LEU P 352
ALA P 323
LEU P 320
ILE P 284
LYS P 303
ILE P 309
None
1.38A 5itzB-6c1dP:
undetectable
5itzB-6c1dP:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9m N-ALPHA-ACETYLTRANSF
ERASE 10
N-ALPHA-ACETYLTRANSF
ERASE 15, NATA
AUXILIARY SUBUNIT


(Homo sapiens)
no annotation 5 LEU A 541
LEU B  11
ASN B  13
MET B  14
ALA B   6
None
1.03A 5itzB-6c9mA:
undetectable
5itzB-6c9mA:
10.21