SIMILAR PATTERNS OF AMINO ACIDS FOR 5IQG_C_51GC600_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcm PHOSPHATIDYLINOSITOL
TRANSFER PROTEIN
ALPHA

(Mus musculus) 		PF02121
(IP_trans) 		5 ASP A 119
TYR A 194
GLU A   6
GLU A 124
TYR A 141
 None
 1.46A 5iqgC-1kcmA:
0.0		 5iqgC-1kcmA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i62 NICOTINAMIDE
N-METHYLTRANSFERASE

(Mus musculus) 		PF01234
(NNMT_PNMT_TEMT) 		5 SER A 248
ASP A 198
TYR A 243
GLU A  35
TYR A  26
 None
None
None
None
SAH  A4001 (-4.4A)
 1.38A 5iqgC-2i62A:
0.0		 5iqgC-2i62A:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a2f DNA POLYMERASE

(Pyrococcus
furiosus) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		5 ASP A 315
TYR A 311
GLU A 288
GLU A 294
TYR A 291
 None
 1.44A 5iqgC-3a2fA:
1.3		 5iqgC-3a2fA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3at7 ALGINATE-BINDING
FLAGELLIN

(Sphingomonas
sp. A1) 		PF09375
(Peptidase_M75) 		5 ASP A 140
TYR A  78
GLU A  82
GLU A 178
GLU A  79
 None
 1.21A 5iqgC-3at7A:
0.0		 5iqgC-3at7A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ckz NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		5 SER A 179
ASP A 198
GLU A 119
GLU A 277
GLU A 227
 ZMR  A 469 ( 4.6A)
None
ZMR  A 469 (-3.5A)
ZMR  A 469 (-3.7A)
ZMR  A 469 (-3.5A)
 1.50A 5iqgC-3ckzA:
1.0		 5iqgC-3ckzA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nrh UNCHARACTERIZED
PROTEIN BF1032

(Bacteroides
fragilis) 		PF16702
(DUF5063) 		5 ASP A 118
ASP A 115
TYR A  76
GLU A  77
GLU A  73
 None
 1.50A 5iqgC-3nrhA:
2.0		 5iqgC-3nrhA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ti8 NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		5 SER A 179
ASP A 198
GLU A 119
GLU A 277
GLU A 227
 LNV  A 901 ( 4.6A)
None
LNV  A 901 (-3.6A)
LNV  A 901 ( 3.8A)
LNV  A 901 (-3.4A)
 1.49A 5iqgC-3ti8A:
1.0		 5iqgC-3ti8A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ayr MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E

(Caulobacter sp.
K31) 		PF01532
(Glyco_hydro_47) 		5 ASP A 245
GLU A 452
GLU A 121
GLU A 427
GLU A 309
 None
IFL  A 503 (-3.1A)
IFL  A 504 ( 4.4A)
IFL  A 503 (-2.9A)
None
 1.46A 5iqgC-4ayrA:
0.0		 5iqgC-4ayrA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ayr MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E

(Caulobacter sp.
K31) 		PF01532
(Glyco_hydro_47) 		5 ASP A 249
ASP A 245
GLU A 452
GLU A 121
GLU A 309
 IFL  A 504 (-2.8A)
None
IFL  A 503 (-3.1A)
IFL  A 504 ( 4.4A)
None
 1.36A 5iqgC-4ayrA:
0.0		 5iqgC-4ayrA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gz4 SNAKE VENOM
PHOSPHODIESTERASE
(PDE)

(Naja atra) 		PF01033
(Somatomedin_B)
PF01223
(Endonuclease_NS)
PF01663
(Phosphodiest) 		5 ASP A 147
SER A 145
ASP A 305
TYR A 300
GLU A 255
 ZN  A 902 (-1.8A)
None
ZN  A 901 (-2.2A)
None
None
 1.10A 5iqgC-5gz4A:
0.0		 5iqgC-5gz4A:
16.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6cey BIFUNCTIONAL AAC/APH

(Staphylococcus
aureus) 		no annotation 5 ASP A 374
SER A 376
ASP A 396
GLU A 411
GLU A 416
 GNP  A 500 (-4.6A)
None
MG  A 702 ( 4.8A)
None
None
 1.39A 5iqgC-6ceyA:
42.8		 5iqgC-6ceyA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6cey BIFUNCTIONAL AAC/APH

(Staphylococcus
aureus) 		no annotation 8 ASP A 374
SER A 376
ASP A 396
TYR A 408
GLU A 411
GLU A 416
TYR A 448
GLU A 451
 GNP  A 500 (-4.6A)
None
MG  A 702 ( 4.8A)
None
None
None
None
None
 0.33A 5iqgC-6ceyA:
42.8		 5iqgC-6ceyA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6cey BIFUNCTIONAL AAC/APH

(Staphylococcus
aureus) 		no annotation 5 ASP A 393
TYR A 408
GLU A 411
GLU A 415
GLU A 416
 MG  A 702 (-1.7A)
None
None
None
None
 1.38A 5iqgC-6ceyA:
42.8		 5iqgC-6ceyA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6cey BIFUNCTIONAL AAC/APH

(Staphylococcus
aureus) 		no annotation 6 TYR A 408
GLU A 411
GLU A 415
GLU A 416
TYR A 448
GLU A 451
 None
 0.75A 5iqgC-6ceyA:
42.8		 5iqgC-6ceyA:
100.00