SIMILAR PATTERNS OF AMINO ACIDS FOR 5IQE_C_NMYC600

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fhu O-SUCCINYLBENZOATE
SYNTHASE

(Escherichia
coli) 		PF13378
(MR_MLE_C) 		5 ASN A 163
GLU A 218
SER A 215
GLU A 191
GLU A 214
 None
 1.38A 5iqeC-1fhuA:
0.0		 5iqeC-1fhuA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ua7 ALPHA-AMYLASE

(Bacillus
subtilis) 		PF00128
(Alpha-amylase) 		5 ASP A 283
SER A 320
GLU A 308
TYR A 271
GLU A 266
 None
 1.35A 5iqeC-1ua7A:
undetectable		 5iqeC-1ua7A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v4a GLUTAMATE-AMMONIA-LI
GASE
ADENYLYLTRANSFERASE

(Escherichia
coli) 		PF03710
(GlnE)
PF08335
(GlnD_UR_UTase) 		5 ASP A 173
SER A 172
ASP A 223
GLU A 381
GLU A 327
 None
 1.35A 5iqeC-1v4aA:
0.9		 5iqeC-1v4aA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xhd PUTATIVE
ACETYLTRANSFERASE/AC
YLTRANSFERASE

(Bacillus cereus) 		PF00132
(Hexapep) 		5 ASP A  76
ASP A  93
SER A  15
GLU A  32
GLU A  33
 None
 1.40A 5iqeC-1xhdA:
0.0		 5iqeC-1xhdA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xrs D-LYSINE
5,6-AMINOMUTASE BETA
SUBUNIT

(Acetoanaerobium
sticklandii) 		PF02310
(B12-binding)
PF16554
(OAM_dimer) 		5 GLU B 108
SER B 105
GLU B 107
GLU B 102
GLU B  46
 None
 1.46A 5iqeC-1xrsB:
2.0		 5iqeC-1xrsB:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ag8 PYRROLINE-5-CARBOXYL
ATE REDUCTASE

(Neisseria
meningitidis) 		PF03807
(F420_oxidored)
PF14748
(P5CR_dimer) 		5 ASP A  59
ASP A  58
TYR A   4
SER A  49
GLU A  47
 None
 1.14A 5iqeC-2ag8A:
1.8		 5iqeC-2ag8A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f2a ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT C
GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A

(Staphylococcus
aureus) 		PF01425
(Amidase)
PF02686
(Glu-tRNAGln) 		5 ASP A 416
GLU C  24
SER C  21
GLU C  23
GLU A 354
 None
 1.47A 5iqeC-2f2aA:
0.0		 5iqeC-2f2aA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fj0 CARBOXYLIC ESTER
HYDROLASE

(Manduca sexta) 		PF00135
(COesterase) 		5 ASP A 560
ASP A 557
TYR A 427
SER A 256
GLU A 336
 None
 1.49A 5iqeC-2fj0A:
0.1		 5iqeC-2fj0A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i5g AMIDOHYDROLASE

(Pseudomonas
aeruginosa) 		PF01244
(Peptidase_M19) 		5 SER A 163
SER A 195
GLU A 197
GLU A 198
GLU A 189
 None
 1.36A 5iqeC-2i5gA:
undetectable		 5iqeC-2i5gA:
21.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3n4t APH(2'')-ID

(Enterococcus
casseliflavus) 		PF01636
(APH) 		5 ASP A 197
SER A 199
ASP A 220
GLU A 235
GLU A 239
 None
 1.48A 5iqeC-3n4tA:
30.8		 5iqeC-3n4tA:
33.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3n4t APH(2'')-ID

(Enterococcus
casseliflavus) 		PF01636
(APH) 		5 ASP A 197
SER A 199
ASP A 220
GLU A 238
GLU A 239
 None
 0.92A 5iqeC-3n4tA:
30.8		 5iqeC-3n4tA:
33.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nrh UNCHARACTERIZED
PROTEIN BF1032

(Bacteroides
fragilis) 		PF16702
(DUF5063) 		5 ASP A 118
ASP A 115
TYR A  76
GLU A  77
GLU A  73
 None
 1.46A 5iqeC-3nrhA:
2.7		 5iqeC-3nrhA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pfo PUTATIVE
ACETYLORNITHINE
DEACETYLASE

(Rhodopseudomonas
palustris) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 SER A 179
ASP A 295
SER A  89
GLU A  44
GLU A 176
 None
 1.31A 5iqeC-3pfoA:
undetectable		 5iqeC-3pfoA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tdw GENTAMICIN
RESISTANCE PROTEIN

(Enterococcus
gallinarum) 		PF01636
(APH) 		5 ASP A 196
SER A 198
ASP A 221
TYR A 233
TYR A 273
 None
None
MG  A 503 ( 4.7A)
None
None
 1.07A 5iqeC-3tdwA:
27.1		 5iqeC-3tdwA:
27.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ved DYPB

(Rhodococcus
jostii) 		PF04261
(Dyp_perox) 		5 ASP A 217
ASP A 219
GLU A 203
GLU A 212
GLU A 200
 None
 1.42A 5iqeC-3vedA:
undetectable		 5iqeC-3vedA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wpe TOLL-LIKE RECEPTOR 9

(Bos taurus) 		PF13516
(LRR_6)
PF13855
(LRR_8) 		5 SER A 130
ASN A 128
ASP A 174
TYR A 131
SER A  71
 None
 1.05A 5iqeC-3wpeA:
undetectable		 5iqeC-3wpeA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bof ARGININE DEIMINASE

(Streptococcus
pyogenes) 		PF02274
(Amidinotransf) 		5 ASP A 241
SER A 244
SER A 176
GLU A 224
GLU A 183
 None
 1.46A 5iqeC-4bofA:
undetectable		 5iqeC-4bofA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dns FAD-LINKED
OXIDOREDUCTASE BG60

(Cynodon
dactylon) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		5 ASP A 485
SER A 454
ASN A 447
ASP A 482
GLU A 490
 None
 1.48A 5iqeC-4dnsA:
undetectable		 5iqeC-4dnsA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hxe PUTATIVE
UNCHARACTERIZED
PROTEIN PH0594

(Pyrococcus
horikoshii) 		PF00326
(Peptidase_S9)
PF07676
(PD40) 		5 SER B 283
ASN B 285
ASP B 364
TYR B 394
GLU B 350
 None
 1.31A 5iqeC-4hxeB:
undetectable		 5iqeC-4hxeB:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pve POLLEN ALLERGEN PHL
P 4.0202

(Phleum pratense) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		5 ASP A 485
ASN A 447
ASP A 482
GLU A  99
GLU A 490
 None
 1.26A 5iqeC-4pveA:
undetectable		 5iqeC-4pveA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pve POLLEN ALLERGEN PHL
P 4.0202

(Phleum pratense) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		5 ASP A 485
SER A 454
ASN A 447
ASP A 482
GLU A 490
 None
 1.41A 5iqeC-4pveA:
undetectable		 5iqeC-4pveA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qfu GLYCOSIDE HYDROLASE
FAMILY 5

(Bacteroides
vulgatus) 		PF12904
(Collagen_bind_2)
PF13204
(DUF4038) 		5 ASP A 391
SER A 408
ASN A 406
TYR A 455
SER A 453
 None
 1.44A 5iqeC-4qfuA:
undetectable		 5iqeC-4qfuA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1

(Homo sapiens;
synthetic
construct) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		5 SER A1536
ASP A1602
SER A1478
GLU A1480
GLU A1482
 None
 1.49A 5iqeC-4rh7A:
undetectable		 5iqeC-4rh7A:
6.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bv5 CYTOCHROME P450 119

(Sulfolobus
solfataricus) 		PF00067
(p450) 		5 ASP A 224
SER A 251
ASN A 355
TYR A 250
GLU A 296
 None
 1.37A 5iqeC-5bv5A:
1.9		 5iqeC-5bv5A:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cxf ENVELOPE
GLYCOPROTEIN B

(Human
betaherpesvirus
5) 		PF00606
(Glycoprotein_B)
PF17416
(Glycoprot_B_PH1)
PF17417
(Glycoprot_B_PH2) 		5 SER A 377
ASP A 362
TYR A 364
SER A 419
GLU A 381
 None
 1.45A 5iqeC-5cxfA:
undetectable		 5iqeC-5cxfA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fhz ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3

(Homo sapiens) 		PF00171
(Aldedh) 		5 ASP A 345
SER A  55
ASN A  53
ASP A 348
GLU A  58
 None
 1.13A 5iqeC-5fhzA:
undetectable		 5iqeC-5fhzA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gz4 SNAKE VENOM
PHOSPHODIESTERASE
(PDE)

(Naja atra) 		PF01033
(Somatomedin_B)
PF01223
(Endonuclease_NS)
PF01663
(Phosphodiest) 		5 ASP A 147
SER A 145
ASP A 305
TYR A 300
GLU A 255
 ZN  A 902 (-1.8A)
None
ZN  A 901 (-2.2A)
None
None
 1.08A 5iqeC-5gz4A:
undetectable		 5iqeC-5gz4A:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lz6 3A
GOLGI RESIDENT
PROTEIN GCP60

(Aichivirus B;
Homo sapiens) 		PF13897
(GOLD_2)
no annotation 		5 SER B  13
ASP B  16
TYR A 525
SER A 393
GLU B  22
 None
 1.37A 5iqeC-5lz6B:
undetectable		 5iqeC-5lz6B:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t58 KLLA0F02343P

(Kluyveromyces
lactis) 		PF05859
(Mis12) 		5 ASN A  40
TYR A  36
GLU A  73
SER A  70
GLU A  69
 None
 1.47A 5iqeC-5t58A:
undetectable		 5iqeC-5t58A:
26.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5udy ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 7

(Homo sapiens) 		PF01663
(Phosphodiest) 		5 ASP A  39
SER A  37
ASP A 199
TYR A 194
SER A 139
 ZN  A 501 (-2.0A)
None
ZN  A 502 (-2.3A)
None
None
 1.18A 5iqeC-5udyA:
0.6		 5iqeC-5udyA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wxi EARP

(Neisseria
meningitidis) 		no annotation 5 SER A 117
ASN A 122
ASP A 297
SER A 145
GLU A 123
 None
 1.10A 5iqeC-5wxiA:
undetectable		 5iqeC-5wxiA:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3j TOLL-LIKE RECEPTOR 9

(Equus caballus) 		no annotation 5 SER A 131
ASN A 129
ASP A 175
TYR A 132
SER A  72
 None
 1.03A 5iqeC-5y3jA:
undetectable		 5iqeC-5y3jA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zln TOLL-LIKE RECEPTOR 9

(Mus musculus) 		no annotation 5 SER A 131
ASN A 129
ASP A 175
TYR A 132
SER A  72
 None
 1.07A 5iqeC-5zlnA:
undetectable		 5iqeC-5zlnA:
17.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6cey BIFUNCTIONAL AAC/APH

(Staphylococcus
aureus) 		no annotation 11 ASP A 374
SER A 376
ASN A 378
ASP A 396
TYR A 408
GLU A 411
SER A 413
GLU A 415
GLU A 416
TYR A 448
GLU A 451
 GNP  A 500 (-4.6A)
None
None
MG  A 702 ( 4.8A)
None
None
None
None
None
None
None
 0.46A 5iqeC-6ceyA:
34.3		 5iqeC-6ceyA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6cey BIFUNCTIONAL AAC/APH

(Staphylococcus
aureus) 		no annotation 7 SER A 376
ASN A 378
GLU A 411
SER A 413
GLU A 415
GLU A 416
GLU A 445
 None
 0.80A 5iqeC-6ceyA:
34.3		 5iqeC-6ceyA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f2t -

(-) 		no annotation 5 ASP A 168
SER A 166
ASP A 326
TYR A 321
SER A 269
 ZN  A1002 (-2.0A)
None
ZN  A1003 ( 2.1A)
None
None
 1.16A 5iqeC-6f2tA:
undetectable		 5iqeC-6f2tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gu8 -

(-) 		no annotation 5 ASN A 301
TYR A 315
SER A 289
GLU A 283
TYR A  64
 None
 1.45A 5iqeC-6gu8A:
undetectable		 5iqeC-6gu8A:
undetectable