SIMILAR PATTERNS OF AMINO ACIDS FOR 5INZ_D_DVAD15_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cl4 PROTEIN (GAG
POLYPROTEIN)

(Mason-Pfizer
monkey virus) 		PF14787
(zf-CCHC_5) 		3 GLY A  59
CYH A  56
CYH A  53
 None
ZN  A  81 (-2.3A)
ZN  A  81 (-2.2A)
 0.91A 5inzB-1cl4A:
undetectable		 5inzB-1cl4A:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dbh PROTEIN (HUMAN SOS
1)

(Homo sapiens) 		PF00169
(PH)
PF00621
(RhoGEF) 		3 GLY A 438
CYH A 441
CYH A 440
 None
 0.93A 5inzB-1dbhA:
undetectable		 5inzB-1dbhA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dsv NUCLEIC ACID BINDING
PROTEIN P14

(Mouse mammary
tumor virus) 		PF14787
(zf-CCHC_5) 		3 GLY A  64
CYH A  61
CYH A  58
 None
ZN  A 171 (-2.3A)
ZN  A 171 (-2.3A)
 0.94A 5inzB-1dsvA:
undetectable		 5inzB-1dsvA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eb3 5-AMINOLAEVULINIC
ACID DEHYDRATASE

(Saccharomyces
cerevisiae) 		PF00490
(ALAD) 		3 GLY A 144
CYH A 133
CYH A 135
 None
ZN  A1342 (-2.2A)
ZN  A1342 (-2.2A)
 0.97A 5inzB-1eb3A:
undetectable		 5inzB-1eb3A:
8.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ee2 ALCOHOL
DEHYDROGENASE

(Equus caballus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 GLY A  98
CYH A 103
CYH A 100
 None
ZN  A1301 (-2.3A)
ZN  A1301 (-2.3A)
 0.96A 5inzB-1ee2A:
undetectable		 5inzB-1ee2A:
5.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1flc HAEMAGGLUTININ-ESTER
ASE-FUSION
GLYCOPROTEIN

(Influenza C
virus) 		PF02710
(Hema_HEFG)
PF03996
(Hema_esterase) 		3 GLY A 397
CYH A 399
CYH A 373
 None
 0.97A 5inzB-1flcA:
undetectable		 5inzB-1flcA:
3.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1geg ACETOIN REDUCTASE

(Klebsiella
pneumoniae) 		PF00106
(adh_short) 		3 GLY A 179
CYH A 181
CYH A 138
 None
 0.76A 5inzB-1gegA:
undetectable		 5inzB-1gegA:
5.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h21 SPLIT-SORET
CYTOCHROME C

(Desulfovibrio
desulfuricans) 		PF09719
(C_GCAxxG_C_C) 		3 GLY A  77
CYH A 147
CYH A  86
 None
 0.77A 5inzB-1h21A:
undetectable		 5inzB-1h21A:
5.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h21 SPLIT-SORET
CYTOCHROME C

(Desulfovibrio
desulfuricans) 		PF09719
(C_GCAxxG_C_C) 		3 GLY A  78
CYH A 147
CYH A  86
 None
 0.80A 5inzB-1h21A:
undetectable		 5inzB-1h21A:
5.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mda METHYLAMINE
DEHYDROGENASE (HEAVY
SUBUNIT)

(Paracoccus
denitrificans) 		PF06433
(Me-amine-dh_H) 		3 GLY H 181
CYH H 183
CYH H 167
 None
 0.63A 5inzB-1mdaH:
undetectable		 5inzB-1mdaH:
5.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2

(Synechocystis
sp. PCC 6803) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		3 GLY A1421
CYH A1402
CYH A1401
 None
 0.83A 5inzB-1ofeA:
undetectable		 5inzB-1ofeA:
1.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ozb PREPROTEIN
TRANSLOCASE SECA
SUBUNIT

(Haemophilus
influenzae) 		PF02810
(SEC-C) 		3 GLY I  13
CYH I  10
CYH I   8
 None
ZN  I  50 (-2.3A)
ZN  I  50 (-2.3A)
 0.96A 5inzB-1ozbI:
undetectable		 5inzB-1ozbI:
25.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qbh INHIBITOR OF
APOPTOSIS PROTEIN
(2MIHB/C-IAP-1)

(Homo sapiens) 		PF00653
(BIR) 		3 GLY A 312
CYH A 309
CYH A 306
 None
ZN  A 364 (-2.2A)
ZN  A 364 (-2.2A)
 0.82A 5inzB-1qbhA:
undetectable		 5inzB-1qbhA:
13.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1sx1 SECA

(-) 		PF02810
(SEC-C) 		3 GLY A  13
CYH A  10
CYH A   8
 None
ZN  A  23 (-2.3A)
ZN  A  23 (-2.3A)
 0.87A 5inzB-1sx1A:
undetectable		 5inzB-1sx1A:
31.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u3t ALCOHOL
DEHYDROGENASE ALPHA
CHAIN

(Homo sapiens) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 GLY A  98
CYH A 103
CYH A 100
 ZN  A 375 ( 4.8A)
ZN  A 375 (-2.2A)
ZN  A 375 (-2.2A)
 0.96A 5inzB-1u3tA:
undetectable		 5inzB-1u3tA:
5.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vj0 ALCOHOL
DEHYDROGENASE,
ZINC-CONTAINING

(Thermotoga
maritima) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 GLY A 101
CYH A 106
CYH A 103
 ZN  A 400 ( 4.9A)
ZN  A 400 (-2.3A)
ZN  A 400 (-2.3A)
 0.93A 5inzB-1vj0A:
undetectable		 5inzB-1vj0A:
7.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xdv SON OF SEVENLESS
PROTEIN HOMOLOG 1

(Homo sapiens) 		PF00169
(PH)
PF00617
(RasGEF)
PF00618
(RasGEF_N)
PF00621
(RhoGEF) 		3 GLY A 438
CYH A 441
CYH A 440
 None
 0.92A 5inzB-1xdvA:
undetectable		 5inzB-1xdvA:
2.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cda GLUCOSE
DEHYDROGENASE

(Sulfolobus
solfataricus) 		PF08240
(ADH_N)
PF16912
(Glu_dehyd_C) 		3 GLY A  94
CYH A  99
CYH A  96
 None
ZN  A1369 (-2.3A)
ZN  A1369 (-2.4A)
 0.80A 5inzB-2cdaA:
undetectable		 5inzB-2cdaA:
6.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dul N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE

(Pyrococcus
horikoshii) 		PF02005
(TRM) 		3 GLY A 189
CYH A 192
CYH A 171
 None
 0.92A 5inzB-2dulA:
undetectable		 5inzB-2dulA:
3.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dul N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE

(Pyrococcus
horikoshii) 		PF02005
(TRM) 		3 GLY A 196
CYH A 171
CYH A 192
 None
 0.79A 5inzB-2dulA:
undetectable		 5inzB-2dulA:
3.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ewl PROTEIN E7

(Alphapapillomavirus
7) 		PF00527
(E7) 		3 GLY A  21
CYH A  19
CYH A  16
 None
ZN  A  57 (-2.4A)
ZN  A  57 (-1.3A)
 0.95A 5inzB-2ewlA:
undetectable		 5inzB-2ewlA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fea 2-HYDROXY-3-KETO-5-M
ETHYLTHIOPENTENYL-1-
PHOSPHATE
PHOSPHATASE

(Bacillus
subtilis) 		PF12710
(HAD) 		3 GLY A 148
CYH A 139
CYH A 150
 None
ZN  A1302 (-2.2A)
ZN  A1302 (-2.3A)
 0.85A 5inzB-2feaA:
undetectable		 5inzB-2feaA:
6.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j2s ZINC FINGER PROTEIN
HRX

(Homo sapiens) 		PF02008
(zf-CXXC) 		3 GLY A1168
CYH A1173
CYH A1170
 None
ZN  A2215 (-2.2A)
ZN  A2215 (-2.2A)
 0.94A 5inzB-2j2sA:
undetectable		 5inzB-2j2sA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jrr UNCHARACTERIZED
PROTEIN

(Ruegeria
pomeroyi) 		PF10276
(zf-CHCC) 		3 GLY A  20
CYH A  48
CYH A  46
 None
 0.93A 5inzB-2jrrA:
undetectable		 5inzB-2jrrA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jyi ZINC FINGER PROTEIN
HRX

(Homo sapiens) 		PF02008
(zf-CXXC) 		3 GLY A1168
CYH A1173
CYH A1170
 ZN  A2002 (-4.5A)
ZN  A2002 (-2.3A)
ZN  A2002 (-2.3A)
 0.93A 5inzB-2jyiA:
undetectable		 5inzB-2jyiA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kgq BRAZZEIN

(Pentadiplandra
brazzeana) 		no annotation 3 GLY A  35
CYH A  37
CYH A  47
 None
 0.84A 5inzB-2kgqA:
undetectable		 5inzB-2kgqA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l6l DNAJ HOMOLOG
SUBFAMILY C MEMBER
24

(Homo sapiens) 		PF00226
(DnaJ)
PF05207
(zf-CSL) 		3 GLY A 119
CYH A 117
CYH A 115
 None
ZN  A 201 (-2.2A)
ZN  A 201 (-2.2A)
 0.83A 5inzB-2l6lA:
undetectable		 5inzB-2l6lA:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m48 E3 UBIQUITIN-PROTEIN
LIGASE PARKIN

(Drosophila
melanogaster) 		PF01485
(IBR) 		3 GLY A 388
CYH A 385
CYH A 382
 None
ZN  A 502 (-2.1A)
ZN  A 502 (-2.1A)
 0.95A 5inzB-2m48A:
undetectable		 5inzB-2m48A:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n95 PROTEIN HIT1

(Saccharomyces
cerevisiae) 		PF04438
(zf-HIT) 		3 GLY A  13
CYH A  11
CYH A   8
 None
ZN  A 101 (-2.3A)
ZN  A 101 (-2.2A)
 0.96A 5inzB-2n95A:
undetectable		 5inzB-2n95A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pg3 QUEUOSINE
BIOSYNTHESIS PROTEIN
QUEC

(Pectobacterium
atrosepticum) 		PF06508
(QueC) 		3 GLY A 198
CYH A 203
CYH A 200
 ZN  A 300 ( 4.9A)
ZN  A 300 (-2.3A)
ZN  A 300 (-2.3A)
 0.91A 5inzB-2pg3A:
undetectable		 5inzB-2pg3A:
5.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rem DISULFIDE
OXIDOREDUCTASE

(Xylella
fastidiosa) 		PF13462
(Thioredoxin_4) 		3 GLY A  35
CYH A  41
CYH A  38
 None
 0.88A 5inzB-2remA:
undetectable		 5inzB-2remA:
8.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v2t TRANSCRIPTION FACTOR
RELB

(Mus musculus) 		PF00554
(RHD_DNA_bind)
PF16179
(RHD_dimer) 		3 GLY A 184
CYH A 186
CYH A 181
 None
 0.55A 5inzB-2v2tA:
undetectable		 5inzB-2v2tA:
4.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yn9 POTASSIUM-TRANSPORTI
NG ATPASE ALPHA
CHAIN 1

(Sus scrofa) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF09040
(H-K_ATPase_N)
PF13246
(Cation_ATPase) 		3 GLY A1018
CYH A1022
CYH A1021
 None
 0.92A 5inzB-2yn9A:
undetectable		 5inzB-2yn9A:
1.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ask E3 UBIQUITIN-PROTEIN
LIGASE UHRF1

(Homo sapiens) 		PF00628
(PHD)
PF12148
(TTD) 		3 GLY A 323
CYH A 321
CYH A 318
 None
ZN  A 502 (-2.3A)
ZN  A 502 (-2.3A)
 0.75A 5inzB-3askA:
undetectable		 5inzB-3askA:
8.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3av6 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus musculus) 		PF00145
(DNA_methylase)
PF01426
(BAH)
PF02008
(zf-CXXC)
PF12047
(DNMT1-RFD) 		3 GLY A 657
CYH A 662
CYH A 659
 None
ZN  A2002 (-2.1A)
ZN  A2002 (-2.3A)
 0.92A 5inzB-3av6A:
undetectable		 5inzB-3av6A:
1.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bl5 QUEUOSINE
BIOSYNTHESIS PROTEIN
QUEC

(Bacillus
subtilis) 		PF06508
(QueC) 		3 GLY A 196
CYH A 201
CYH A 198
 None
ZN  A 300 (-2.3A)
ZN  A 300 (-2.2A)
 0.92A 5inzB-3bl5A:
undetectable		 5inzB-3bl5A:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR

(Homo sapiens) 		PF00856
(SET)
PF05033
(Pre-SET) 		3 GLY A 276
CYH A 280
CYH A 212
 None
ZN  A 304 (-2.3A)
ZN  A 304 (-2.4A)
 0.97A 5inzB-3bo5A:
undetectable		 5inzB-3bo5A:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c10 HISTONE DEACETYLASE
7A

(Homo sapiens) 		PF00850
(Hist_deacetyl) 		3 GLY A 620
CYH A 533
CYH A 535
 ZN  A 102 ( 4.8A)
ZN  A 102 (-2.4A)
ZN  A 102 (-2.3A)
 0.97A 5inzB-3c10A:
undetectable		 5inzB-3c10A:
3.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ip1 ALCOHOL
DEHYDROGENASE,
ZINC-CONTAINING

(Thermotoga
maritima) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 GLY A 132
CYH A 137
CYH A 134
 CD  A 500 ( 4.7A)
CD  A 500 (-2.4A)
CD  A 500 (-2.4A)
 0.97A 5inzB-3ip1A:
undetectable		 5inzB-3ip1A:
5.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j7y BS18A

(Homo sapiens) 		PF00453
(Ribosomal_L20) 		3 GLY r  68
CYH r  73
CYH r  70
 None
ZN  r 200 (-3.1A)
ZN  r 200 (-2.0A)
 0.91A 5inzB-3j7yr:
undetectable		 5inzB-3j7yr:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jv7 ADH-A

(Rhodococcus
ruber) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 GLY A  93
CYH A  98
CYH A  95
 ZN  A 501 ( 4.8A)
ZN  A 501 (-2.3A)
ZN  A 501 (-2.3A)
 0.96A 5inzB-3jv7A:
undetectable		 5inzB-3jv7A:
4.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ksy SON OF SEVENLESS
HOMOLOG 1

(Homo sapiens) 		PF00125
(Histone)
PF00169
(PH)
PF00617
(RasGEF)
PF00618
(RasGEF_N)
PF00621
(RhoGEF) 		3 GLY A 438
CYH A 441
CYH A 440
 None
 0.94A 5inzB-3ksyA:
undetectable		 5inzB-3ksyA:
1.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lwa SECRETED
THIOL-DISULFIDE
ISOMERASE

(Corynebacterium
glutamicum) 		PF00578
(AhpC-TSA) 		3 GLY A  92
CYH A  98
CYH A  95
 None
 0.73A 5inzB-3lwaA:
undetectable		 5inzB-3lwaA:
9.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3meq ALCOHOL
DEHYDROGENASE,
ZINC-CONTAINING

(Brucella suis) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 GLY A  97
CYH A 102
CYH A  99
 ZN  A 501 ( 4.9A)
ZN  A 501 (-2.4A)
ZN  A 501 (-2.3A)
 0.97A 5inzB-3meqA:
undetectable		 5inzB-3meqA:
4.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o0m HIT FAMILY PROTEIN

(Mycolicibacterium
smegmatis) 		PF01230
(HIT) 		3 GLY A  -1
CYH A   6
CYH A   3
 None
ZN  A 151 (-2.3A)
ZN  A 151 (-2.2A)
 0.77A 5inzB-3o0mA:
undetectable		 5inzB-3o0mA:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pta DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Homo sapiens) 		PF00145
(DNA_methylase)
PF01426
(BAH)
PF02008
(zf-CXXC) 		3 GLY A 654
CYH A 659
CYH A 656
 None
ZN  A   2 (-2.4A)
ZN  A   2 (-2.2A)
 0.86A 5inzB-3ptaA:
undetectable		 5inzB-3ptaA:
1.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qmh CPG-BINDING PROTEIN

(Homo sapiens) 		PF02008
(zf-CXXC) 		3 GLY A 170
CYH A 175
CYH A 172
 ZN  A 300 ( 4.8A)
ZN  A 300 (-2.4A)
ZN  A 300 (-2.1A)
 0.94A 5inzB-3qmhA:
undetectable		 5inzB-3qmhA:
28.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3riq TAILSPIKE PROTEIN

(Salmonella
virus 9NA) 		PF09251
(PhageP22-tail) 		3 GLY A 452
CYH A 405
CYH A 450
 None
 0.86A 5inzB-3riqA:
undetectable		 5inzB-3riqA:
2.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ro2 G-PROTEIN-SIGNALING
MODULATOR 2

(Mus musculus) 		PF13176
(TPR_7)
PF13424
(TPR_12) 		3 GLY A  31
CYH A  33
CYH A  28
 None
 0.97A 5inzB-3ro2A:
undetectable		 5inzB-3ro2A:
4.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ro2 G-PROTEIN-SIGNALING
MODULATOR 2

(Mus musculus) 		PF13176
(TPR_7)
PF13424
(TPR_12) 		3 GLY A  36
CYH A  28
CYH A  33
 None
 0.90A 5inzB-3ro2A:
undetectable		 5inzB-3ro2A:
4.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3se7 VANA

(-) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		3 GLY A 284
CYH A 119
CYH A 282
 None
 0.93A 5inzB-3se7A:
undetectable		 5inzB-3se7A:
4.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u50 TELOMERASE-ASSOCIATE
D PROTEIN 82

(Tetrahymena
thermophila) 		PF08646
(Rep_fac-A_C) 		3 GLY C 559
CYH C 557
CYH C 555
 None
ZN  C 684 (-1.3A)
ZN  C 684 (-2.6A)
 0.84A 5inzB-3u50C:
undetectable		 5inzB-3u50C:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wic GLUCOSE
1-DEHYDROGENASE

(Thermoplasma
volcanium) 		PF08240
(ADH_N)
PF16912
(Glu_dehyd_C) 		3 GLY A  97
CYH A 102
CYH A  99
 ZN  A1002 ( 4.9A)
ZN  A1002 (-2.2A)
ZN  A1002 (-2.5A)
 0.88A 5inzB-3wicA:
undetectable		 5inzB-3wicA:
4.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a11 DNA EXCISION REPAIR
PROTEIN ERCC-8

(Homo sapiens) 		PF00400
(WD40) 		3 GLY B 176
CYH B 178
CYH B 171
 None
 0.67A 5inzB-4a11B:
undetectable		 5inzB-4a11B:
4.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a1s PARTNER OF
INSCUTEABLE

(Drosophila
melanogaster) 		PF13176
(TPR_7)
PF13424
(TPR_12) 		3 GLY A  57
CYH A  59
CYH A  54
 None
 0.92A 5inzB-4a1sA:
undetectable		 5inzB-4a1sA:
5.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a1s PARTNER OF
INSCUTEABLE

(Drosophila
melanogaster) 		PF13176
(TPR_7)
PF13424
(TPR_12) 		3 GLY A  62
CYH A  54
CYH A  59
 None
 0.93A 5inzB-4a1sA:
undetectable		 5inzB-4a1sA:
5.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bom ENVELOPE
GLYCOPROTEIN B

(Human
alphaherpesvirus
1) 		PF00606
(Glycoprotein_B)
PF17416
(Glycoprot_B_PH1)
PF17417
(Glycoprot_B_PH2) 		3 GLY A 594
CYH A 633
CYH A 596
 None
 0.74A 5inzB-4bomA:
undetectable		 5inzB-4bomA:
3.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d4w METHYL-CPG-BINDING
DOMAIN PROTEIN 1

(Homo sapiens) 		PF02008
(zf-CXXC) 		3 GLY A  16
CYH A  21
CYH A  18
 None
 0.87A 5inzB-4d4wA:
undetectable		 5inzB-4d4wA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eex ALCOHOL
DEHYDROGENASE 1

(Lactococcus
lactis) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 GLY A  92
CYH A  97
CYH A  94
 ZN  A 401 ( 4.8A)
ZN  A 401 (-2.3A)
ZN  A 401 (-2.2A)
 0.94A 5inzB-4eexA:
undetectable		 5inzB-4eexA:
5.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ej6 PUTATIVE
ZINC-BINDING
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 GLY A  89
CYH A  94
CYH A  91
 ZN  A 418 ( 4.8A)
ZN  A 418 (-2.3A)
ZN  A 418 (-2.3A)
 0.96A 5inzB-4ej6A:
undetectable		 5inzB-4ej6A:
5.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hp1 LOC100036628 PROTEIN

(Xenopus
tropicalis) 		PF02008
(zf-CXXC) 		3 GLY C  66
CYH C  71
CYH C  68
 ZN  C 201 ( 4.8A)
ZN  C 201 (-2.3A)
ZN  C 201 (-2.3A)
 0.97A 5inzB-4hp1C:
undetectable		 5inzB-4hp1C:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i1f E3 UBIQUITIN-PROTEIN
LIGASE PARKIN

(Homo sapiens) 		PF01485
(IBR) 		3 GLY A 152
CYH A 150
CYH A 154
 None
ZN  A 501 (-2.2A)
ZN  A 501 (-2.3A)
 0.92A 5inzB-4i1fA:
undetectable		 5inzB-4i1fA:
5.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ium PAPAIN-LIKE PROTEASE
2

(Equine
arteritis virus) 		PF05412
(Peptidase_C33)
PF14755
(ER-remodelling) 		3 GLY A 352
CYH A 354
CYH A 349
 None
ZN  A 501 (-2.3A)
ZN  A 501 (-2.3A)
 0.96A 5inzB-4iumA:
undetectable		 5inzB-4iumA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jbh ALCOHOL
DEHYDROGENASE (ZINC)

(Pyrobaculum
aerophilum) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 GLY A  92
CYH A  97
CYH A  94
 ZN  A 401 ( 4.8A)
ZN  A 401 ( 2.2A)
ZN  A 401 ( 2.2A)
 0.96A 5inzB-4jbhA:
undetectable		 5inzB-4jbhA:
6.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jlw GLUTATHIONE-INDEPEND
ENT FORMALDEHYDE
DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 GLY A  99
CYH A 104
CYH A 101
 ZN  A 401 ( 4.9A)
ZN  A 401 (-2.2A)
ZN  A 401 (-2.3A)
 0.97A 5inzB-4jlwA:
undetectable		 5inzB-4jlwA:
5.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nen INTEGRIN ALPHA-X

(Homo sapiens) 		PF00092
(VWA)
PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		3 GLY A  55
CYH A  57
CYH A  50
 None
 0.75A 5inzB-4nenA:
undetectable		 5inzB-4nenA:
1.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nw3 HISTONE-LYSINE
N-METHYLTRANSFERASE
2A

(Homo sapiens) 		PF02008
(zf-CXXC) 		3 GLY A1156
CYH A1161
CYH A1158
 ZN  A1302 (-4.5A)
ZN  A1302 (-2.3A)
ZN  A1302 (-2.3A)
 0.97A 5inzB-4nw3A:
undetectable		 5inzB-4nw3A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oh1 L-IDITOL
2-DEHYDROGENASE

([Clostridium]
scindens) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 GLY A 106
CYH A 111
CYH A 108
 ZN  A 402 ( 4.8A)
ZN  A 402 (-2.4A)
ZN  A 402 (-2.3A)
 0.97A 5inzB-4oh1A:
undetectable		 5inzB-4oh1A:
4.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4plf LACTATE
DEHYDROGENASE

(Apicomplexa) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		3 GLY A 153
CYH A 266
CYH A 268
 None
 0.96A 5inzB-4plfA:
undetectable		 5inzB-4plfA:
3.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ruv THIOREDOXIN

(Staphylococcus
aureus) 		PF00085
(Thioredoxin) 		3 GLY A  27
CYH A  32
CYH A  29
 None
 0.95A 5inzB-4ruvA:
undetectable		 5inzB-4ruvA:
7.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tmu RECQ

(Cronobacter
sakazakii) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF09382
(RQC)
PF16124
(RecQ_Zn_bind) 		3 GLY A 398
CYH A 403
CYH A 400
 ZN  A 601 ( 4.9A)
ZN  A 601 (-2.3A)
ZN  A 601 (-2.3A)
 0.96A 5inzB-4tmuA:
undetectable		 5inzB-4tmuA:
3.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tvr E3 UBIQUITIN-PROTEIN
LIGASE UHRF2

(Homo sapiens) 		PF00628
(PHD)
PF12148
(TTD) 		3 GLY A 352
CYH A 350
CYH A 347
 None
ZN  A 402 (-2.3A)
ZN  A 402 (-2.3A)
 0.96A 5inzB-4tvrA:
undetectable		 5inzB-4tvrA:
5.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4txd CSC2

(Thermofilum
pendens) 		no annotation 3 GLY A 150
CYH A 155
CYH A 152
 ZN  A 401 ( 4.9A)
ZN  A 401 (-2.3A)
ZN  A 401 (-2.2A)
 0.94A 5inzB-4txdA:
undetectable		 5inzB-4txdA:
6.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4z3c METHYLCYTOSINE
DIOXYGENASE

(Homo sapiens) 		PF02008
(zf-CXXC) 		3 GLY C  58
CYH C  63
CYH C  60
 ZN  C 101 ( 4.7A)
ZN  C 101 (-2.3A)
ZN  C 101 (-2.3A)
 0.95A 5inzB-4z3cC:
undetectable		 5inzB-4z3cC:
33.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z6k ALCOHOL
DEHYDROGENASE

(Moraxella sp.
TAE123) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 GLY A  93
CYH A  98
CYH A  95
 ZN  A 402 ( 4.7A)
ZN  A 402 (-2.3A)
ZN  A 402 (-2.3A)
 0.96A 5inzB-4z6kA:
undetectable		 5inzB-4z6kA:
5.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a6c G-PROTEIN-SIGNALING
MODULATOR 2, AFADIN

(Homo sapiens) 		PF13176
(TPR_7)
PF13181
(TPR_8)
PF13424
(TPR_12) 		3 GLY A  31
CYH A  33
CYH A  28
 None
 0.97A 5inzB-5a6cA:
undetectable		 5inzB-5a6cA:
5.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cjs DESIGNED INFLUENZA
HEMAGGLUTININ STEM
#4454, HA1
DESIGNED INFLUENZA
HEMAGGLUTININ STEM
#4454, HA2

(synthetic
construct;
synthetic
construct) 		PF00509
(Hemagglutinin)
PF00509
(Hemagglutinin) 		3 GLY D   8
CYH D 137
CYH C  14
 None
 0.80A 5inzB-5cjsD:
undetectable		 5inzB-5cjsD:
4.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5exh METHYLCYTOSINE
DIOXYGENASE TET3

(Mus musculus) 		PF02008
(zf-CXXC) 		3 GLY C  58
CYH C  63
CYH C  60
 ZN  C 201 ( 4.7A)
ZN  C 201 (-2.3A)
ZN  C 201 (-2.3A)
 0.97A 5inzB-5exhC:
undetectable		 5inzB-5exhC:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5exh METHYLCYTOSINE
DIOXYGENASE TET3

(Mus musculus) 		PF02008
(zf-CXXC) 		3 GLY C  70
CYH C  75
CYH C  72
 ZN  C 202 ( 4.8A)
ZN  C 202 (-2.3A)
ZN  C 202 (-2.3A)
 0.96A 5inzB-5exhC:
undetectable		 5inzB-5exhC:
33.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C

(Homo sapiens) 		PF00856
(SET) 		3 GLY A4902
CYH A4906
CYH A4851
 None
ZN  A5001 (-2.4A)
ZN  A5001 (-2.1A)
 0.94A 5inzB-5f59A:
undetectable		 5inzB-5f59A:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fi5 TETRAHYDROALSTONINE
SYNTHASE

(Catharanthus
roseus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 GLY A 108
CYH A 113
CYH A 110
 ZN  A 401 ( 4.8A)
ZN  A 401 (-2.3A)
ZN  A 401 (-2.3A)
 0.94A 5inzB-5fi5A:
undetectable		 5inzB-5fi5A:
5.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h82 HETEROYOHIMBINE
SYNTHASE THAS2

(Catharanthus
roseus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 GLY A 102
CYH A 107
CYH A 104
 ZN  A1002 ( 4.9A)
ZN  A1002 (-2.3A)
ZN  A1002 (-2.3A)
 0.90A 5inzB-5h82A:
undetectable		 5inzB-5h82A:
6.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5it5 ATP BINDING
MOTIF-CONTAINING
PROTEIN PILF

(Thermus
thermophilus) 		no annotation 3 GLY F 814
CYH F 785
CYH F 782
 None
ZN  F 901 (-2.3A)
ZN  F 901 (-2.4A)
 0.98A 5inzB-5it5F:
undetectable		 5inzB-5it5F:
5.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5itw DIHYDROANTICAPSIN
7-DEHYDROGENASE

(Bacillus
subtilis) 		PF13561
(adh_short_C2) 		3 GLY A 143
CYH A 140
CYH A 183
 None
 0.86A 5inzB-5itwA:
undetectable		 5inzB-5itwA:
5.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l7l ELP3 FAMILY, ELP3
FAMILY

(Dehalococcoides
mccartyi) 		PF04055
(Radical_SAM)
PF16199
(Radical_SAM_C) 		3 GLY A  25
CYH A  30
CYH A  27
 None
FES  A 502 (-2.3A)
FES  A 502 (-2.3A)
 0.85A 5inzB-5l7lA:
undetectable		 5inzB-5l7lA:
5.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lkz HISTONE
ACETYLTRANSFERASE
P300,HISTONE
ACETYLTRANSFERASE
P300

(Homo sapiens) 		PF00439
(Bromodomain)
PF06001
(DUF902)
PF08214
(HAT_KAT11) 		3 GLY A1179
CYH A1177
CYH A1183
 None
ZN  A1701 (-2.3A)
ZN  A1701 (-2.3A)
 0.84A 5inzB-5lkzA:
undetectable		 5inzB-5lkzA:
3.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ng6 CRISPR-ASSOCIATED
ENDONUCLEASE CPF1

(Francisella
tularensis) 		no annotation 3 GLY A1188
CYH A1190
CYH A1116
 None
 0.92A 5inzB-5ng6A:
undetectable		 5inzB-5ng6A:
1.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tnx ALCOHOL
DEHYDROGENASE
ZINC-BINDING DOMAIN
PROTEIN

(Burkholderia
ambifaria) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 GLY A  98
CYH A 103
CYH A 100
 ZN  A 400 ( 4.6A)
ZN  A 400 (-2.3A)
ZN  A 400 (-2.3A)
 0.95A 5inzB-5tnxA:
undetectable		 5inzB-5tnxA:
3.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vbn DNA POLYMERASE
EPSILON CATALYTIC
SUBUNIT A

(Homo sapiens) 		no annotation 3 GLY B2240
CYH B2238
CYH B2236
 None
ZN  B2302 (-2.3A)
ZN  B2302 (-2.3A)
 0.86A 5inzB-5vbnB:
undetectable		 5inzB-5vbnB:
9.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vc9 CXXC-TYPE ZINC
FINGER PROTEIN 4

(Homo sapiens) 		PF02008
(zf-CXXC) 		3 GLY C 140
CYH C 145
CYH C 142
 ZN  C1001 ( 4.7A)
ZN  C1001 (-2.3A)
ZN  C1001 (-2.2A)
 0.97A 5inzB-5vc9C:
undetectable		 5inzB-5vc9C:
30.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vm2 ALCOHOL
DEHYDROGENASE

(Escherichia
coli) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 GLY A  96
CYH A 101
CYH A  98
 ZN  A 402 ( 4.7A)
ZN  A 402 (-2.4A)
ZN  A 402 (-2.3A)
 0.96A 5inzB-5vm2A:
undetectable		 5inzB-5vm2A:
6.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w8u ORF1AB PROTEIN

(Middle East
respiratory
syndrome-related
coronavirus) 		PF08715
(Viral_protease) 		3 GLY A 230
CYH A 228
CYH A 226
 None
ZN  A 401 (-2.2A)
ZN  A 401 (-2.3A)
 0.98A 5inzB-5w8uA:
undetectable		 5inzB-5w8uA:
5.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xfo PHD FINGER PROTEIN 1

(Homo sapiens) 		PF00628
(PHD) 		3 GLY A 193
CYH A 191
CYH A 189
 None
ZN  A 403 (-2.3A)
ZN  A 403 (-2.3A)
 0.91A 5inzB-5xfoA:
undetectable		 5inzB-5xfoA:
7.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xfr METAL-RESPONSE
ELEMENT-BINDING
TRANSCRIPTION FACTOR
2

(Homo sapiens) 		PF00628
(PHD) 		3 GLY A 208
CYH A 206
CYH A 204
 None
ZN  A 404 (-2.4A)
ZN  A 404 (-2.4A)
 0.92A 5inzB-5xfrA:
undetectable		 5inzB-5xfrA:
6.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyi 40S RIBOSOMAL
PROTEIN S27

(Trichomonas
vaginalis) 		PF01015
(Ribosomal_S3Ae) 		3 GLY b  43
CYH b  41
CYH b  38
 None
 0.95A 5inzB-5xyib:
undetectable		 5inzB-5xyib:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6asd METHYLCYTOSINE
DIOXYGENASE TET1

(Homo sapiens) 		no annotation 3 GLY C 592
CYH C 597
CYH C 594
 ZN  C 701 (-4.6A)
ZN  C 701 (-2.2A)
ZN  C 701 (-2.1A)
 0.92A 5inzB-6asdC:
undetectable		 5inzB-6asdC:
26.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6asd METHYLCYTOSINE
DIOXYGENASE TET1

(Homo sapiens) 		no annotation 3 GLY C 604
CYH C 609
CYH C 606
 ZN  C 702 ( 4.8A)
ZN  C 702 (-2.3A)
ZN  C 702 (-2.3A)
 0.94A 5inzB-6asdC:
undetectable		 5inzB-6asdC:
26.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cen HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD3

(Homo sapiens) 		no annotation 3 GLY A1276
CYH A1280
CYH A1226
 None
ZN  A1304 (-2.3A)
ZN  A1304 (-2.3A)
 0.93A 5inzB-6cenA:
undetectable		 5inzB-6cenA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dkh L-IDONATE
5-DEHYDROGENASE
(NAD(P)(+))

(Escherichia
coli) 		no annotation 3 GLY A  94
CYH A  99
CYH A  96
 None
ZN  A 401 (-2.3A)
ZN  A 401 (-2.4A)
 0.81A 5inzB-6dkhA:
undetectable		 5inzB-6dkhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6esq PFAM DUF35

(Methanothermococcus
thermolithotrophicus) 		no annotation 3 GLY E  41
CYH E  37
CYH E  34
 None
ZN  E 201 (-2.5A)
ZN  E 201 (-2.2A)
 0.89A 5inzB-6esqE:
undetectable		 5inzB-6esqE:
undetectable