SIMILAR PATTERNS OF AMINO ACIDS FOR 5IM2_A_BEZA401_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)

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	Hit	Macromolecule/ Organism	Pfam	Res.	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4p56	PUTATIVE EXTRACELLULAR SOLUTE-BINDING PROTEIN (Bordetella bronchiseptica)	PF03480 (DctP)	4	TYR A 94 ARG A 170 PRO A 210 GLU A 212	RMN A 401 (-4.6A) RMN A 401 (-2.8A) RMN A 401 ( 4.4A) RMN A 401 ( 4.4A)	0.95A	5im2A-4p56A: 40.9	5im2A-4p56A: 32.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5i5p	TRAP TRANSPORTER SOLUTE BINDING PROTEIN (uncultured marine bacterium)	PF03480 (DctP)	4	TYR A 95 ARG A 169 PRO A 209 GLU A 211	PHB A 401 (-4.5A) PHB A 401 (-3.0A) PHB A 401 ( 4.0A) PHB A 401 (-3.1A)	0.28A	5im2A-5i5pA: 49.0	5im2A-5i5pA: 50.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5im2	TWIN-ARGININE TRANSLOCATION PATHWAY SIGNAL (Rhodoferax ferrireducens)	PF03480 (DctP)	4	TYR A 96 ARG A 170 PRO A 210 GLU A 212	BEZ A 401 (-4.8A) BEZ A 401 (-2.8A) BEZ A 401 (-3.8A) BEZ A 401 (-3.6A)	0.03A	5im2A-5im2A: 59.8	5im2A-5im2A: 100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5lcw	CELL DIVISION CYCLE PROTEIN 20 HOMOLOG MITOTIC CHECKPOINT SERINE/THREONINE-PRO TEIN KINASE BUB1 BETA,MITOTIC CHECKPOINT SERINE/THREONINE-PRO TEIN KINASE BUB1 BETA (Homo sapiens; Homo sapiens)	PF00400 (WD40) PF12894 (ANAPC4_WD40) PF08311 (Mad3_BUB1_I)	4	TYR R 228 ARG R 286 PRO S 135 GLU S 161	None	1.47A	5im2A-5lcwR: 0.0	5im2A-5lcwR: 21.78

[["5IM2_A_BEZA401_1","4p56","Bordetella bronchiseptica","PUTATIVE EXTRACELLULAR SOLUTE-BINDING PROTEIN","PF03480(DctP)",4,"TYR A  94;ARG A 170;PRO A 210;GLU A 212","RMN A 401 (-4.6A);RMN A 401 (-2.8A);RMN A 401 ( 4.4A);RMN A 401 ( 4.4A)","0.95A","5im2A-4p56A:40.9","5im2A-4p56A:32.14"],["5IM2_A_BEZA401_1","5i5p","uncultured marine bacterium","TRAP TRANSPORTER SOLUTE BINDING PROTEIN","PF03480(DctP)",4,"TYR A  95;ARG A 169;PRO A 209;GLU A 211","PHB A 401 (-4.5A);PHB A 401 (-3.0A);PHB A 401 ( 4.0A);PHB A 401 (-3.1A)","0.28A","5im2A-5i5pA:49.0","5im2A-5i5pA:50.00"],["5IM2_A_BEZA401_1","5im2","Rhodoferax ferrireducens","TWIN-ARGININE TRANSLOCATION PATHWAY SIGNAL","PF03480(DctP)",4,"TYR A  96;ARG A 170;PRO A 210;GLU A 212","BEZ A 401 (-4.8A);BEZ A 401 (-2.8A);BEZ A 401 (-3.8A);BEZ A 401 (-3.6A)","0.03A","5im2A-5im2A:59.8","5im2A-5im2A:100.00"],["5IM2_A_BEZA401_1","5lcw","Homo sapiens;Homo sapiens","CELL DIVISION CYCLE PROTEIN 20 HOMOLOG;MITOTIC CHECKPOINT SERINE\/THREONINE-PROTEIN KINASE BUB1 BETA,MITOTIC CHECKPOINT SERINE\/THREONINE-PROTEIN KINASE BUB1 BETA","PF00400(WD40);PF12894(ANAPC4_WD40);PF08311(Mad3_BUB1_I)",4,"TYR R 228;ARG R 286;PRO S 135;GLU S 161","None","1.47A","5im2A-5lcwR:0.0","5im2A-5lcwR:21.78"]]