SIMILAR PATTERNS OF AMINO ACIDS FOR 5IL1_A_SAMA601_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ong 4S-LIMONENE SYNTHASE

(Mentha spicata) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		4 ASP A 353
HIS A 579
ASN A  64
GLN A 582
 None
FPG  A 600 (-3.3A)
None
None
 1.35A 5il1A-2ongA:
undetectable		 5il1A-2ongA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qf5 CELL SHAPE
DETERMINING PROTEIN
MREC

(Streptococcus
pneumoniae) 		PF04085
(MreC) 		4 ASP A 201
HIS A 261
ASN A 171
GLN A 128
 None
 1.26A 5il1A-2qf5A:
0.0		 5il1A-2qf5A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kl0 GLUCURONOXYLANASE
XYNC

(Bacillus
subtilis) 		PF17189
(Glyco_hydro_30C) 		4 ASP A  57
HIS A 117
ASN A 139
GLN A 138
 None
 1.28A 5il1A-3kl0A:
0.7		 5il1A-3kl0A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t5o COMPLEMENT COMPONENT
C6

(Homo sapiens) 		PF00057
(Ldl_recept_a)
PF00084
(Sushi)
PF00090
(TSP_1)
PF01823
(MACPF) 		4 ASP A 315
HIS A 312
ASN A 174
GLN A 170
 None
 1.44A 5il1A-3t5oA:
0.0		 5il1A-3t5oA:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g76 PHOSPHODIESTERASE

(Pseudomonas
aeruginosa) 		PF14859
(Colicin_M) 		4 ASP A 135
HIS A 150
ASN A  98
GLN A  94
 None
 1.42A 5il1A-4g76A:
0.0		 5il1A-4g76A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h41 PUTATIVE
ALPHA-L-FUCOSIDASE

(Bacteroides
thetaiotaomicron) 		PF14488
(DUF4434)
PF17134
(DUF5109) 		4 ASP A  66
HIS A  70
ASN A 299
GLN A 269
 None
1PE  A 406 ( 2.7A)
UNL  A 401 ( 3.6A)
UNL  A 401 ( 3.7A)
 1.48A 5il1A-4h41A:
0.0		 5il1A-4h41A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qaw XYN30D

(Paenibacillus
barcinonensis) 		PF03422
(CBM_6)
PF17189
(Glyco_hydro_30C) 		4 ASP A  56
HIS A 115
ASN A 137
GLN A 136
 None
 1.29A 5il1A-4qawA:
0.9		 5il1A-4qawA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uq9 CARBOHYDRATE BINDING
FAMILY 6

(Ruminiclostridium
thermocellum) 		PF17189
(Glyco_hydro_30C) 		4 ASP A  53
HIS A 113
ASN A 135
GLN A 134
 None
 1.27A 5il1A-4uq9A:
1.0		 5il1A-4uq9A:
17.71