SIMILAR PATTERNS OF AMINO ACIDS FOR 5IKT_B_TLFB601

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a59 CITRATE SYNTHASE

(Antarctic
bacterium
DS2-3R) 		PF00285
(Citrate_synt) 		5 SER A 102
VAL A  80
GLY A  82
ALA A  83
LEU A  87
 None
 1.29A 5iktB-1a59A:
0.0		 5iktB-1a59A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b3b PROTEIN (GLUTAMATE
DEHYDROGENASE)

(Thermotoga
maritima) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		5 VAL A  95
LEU A 370
VAL A 345
GLY A 343
ALA A 342
 None
 1.01A 5iktB-1b3bA:
0.0		 5iktB-1b3bA:
21.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ebv PROSTAGLANDIN H2
SYNTHASE

(Ovis aries) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		11 VAL A 116
ARG A 120
VAL A 349
LEU A 352
SER A 353
LEU A 384
TRP A 387
MET A 522
GLY A 526
ALA A 527
LEU A 531
 None
SCL  A 700 (-3.9A)
SCL  A 700 ( 4.6A)
SCL  A 700 ( 4.8A)
None
None
None
None
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
OAS  A 530 (-4.1A)
 0.44A 5iktB-1ebvA:
58.8		 5iktB-1ebvA:
63.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ia5 POLYGALACTURONASE

(Aspergillus
aculeatus) 		PF00295
(Glyco_hydro_28) 		5 VAL A  26
SER A  28
LEU A 120
GLY A  78
ALA A  79
 None
 1.14A 5iktB-1ia5A:
undetectable		 5iktB-1ia5A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1itu RENAL DIPEPTIDASE

(Homo sapiens) 		PF01244
(Peptidase_M19) 		5 VAL A 247
LEU A 246
GLY A 279
ALA A 278
LEU A 237
 None
 1.30A 5iktB-1ituA:
0.0		 5iktB-1ituA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l1f GLUTAMATE
DEHYDROGENASE 1

(Homo sapiens) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		5 VAL A 121
LEU A 457
VAL A 382
GLY A 380
ALA A 379
 None
 1.05A 5iktB-1l1fA:
0.0		 5iktB-1l1fA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m0s RIBOSE-5-PHOSPHATE
ISOMERASE A

(Haemophilus
influenzae) 		PF06026
(Rib_5-P_isom_A) 		5 VAL A 106
SER A  56
VAL A  67
GLY A  48
ALA A  49
 None
 1.08A 5iktB-1m0sA:
undetectable		 5iktB-1m0sA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n97 CYP175A1

(Thermus
thermophilus) 		PF00067
(p450) 		5 LEU A 149
SER A 150
LEU A 203
ALA A 194
LEU A 190
 None
 1.31A 5iktB-1n97A:
0.0		 5iktB-1n97A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nj8 PROLINE-TRNA
SYNTHETASE

(Methanocaldococcus
jannaschii) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09181
(ProRS-C_2) 		5 VAL A 433
VAL A 418
LEU A 417
GLY A 439
LEU A 429
 None
 1.12A 5iktB-1nj8A:
0.0		 5iktB-1nj8A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1no7 MAJOR CAPSID PROTEIN

(Human
alphaherpesvirus
1) 		PF03122
(Herpes_MCP) 		5 VAL A1010
LEU A 700
GLY A 596
ALA A1023
LEU A1020
 None
 1.25A 5iktB-1no7A:
undetectable		 5iktB-1no7A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nty TRIPLE FUNCTIONAL
DOMAIN PROTEIN

(Homo sapiens) 		PF00169
(PH)
PF00621
(RhoGEF) 		5 VAL A1458
LEU A1457
SER A1456
TRP A1523
LEU A1411
 None
 1.22A 5iktB-1ntyA:
undetectable		 5iktB-1ntyA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nty TRIPLE FUNCTIONAL
DOMAIN PROTEIN

(Homo sapiens) 		PF00169
(PH)
PF00621
(RhoGEF) 		5 VAL A1458
LEU A1457
SER A1456
TRP A1523
LEU A1414
 None
 1.23A 5iktB-1ntyA:
undetectable		 5iktB-1ntyA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tt7 YHFP

(Bacillus
subtilis) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 VAL A 205
LEU A 147
GLY A 220
ALA A 221
LEU A 233
 None
 1.31A 5iktB-1tt7A:
undetectable		 5iktB-1tt7A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ued P450 MONOOXYGENASE

(Amycolatopsis
orientalis) 		PF00067
(p450) 		5 VAL A 404
LEU A 289
MET A 253
GLY A 257
LEU A 262
 None
None
HEM  A1430 (-4.6A)
None
None
 1.31A 5iktB-1uedA:
undetectable		 5iktB-1uedA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1umf CHORISMATE SYNTHASE

(Helicobacter
pylori) 		PF01264
(Chorismate_synt) 		5 LEU A 341
VAL A 133
GLY A 136
ALA A 137
LEU A  38
 None
 1.19A 5iktB-1umfA:
undetectable		 5iktB-1umfA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vbr ENDO-1,4-BETA-XYLANA
SE B

(Thermotoga
maritima) 		PF00331
(Glyco_hydro_10) 		5 LEU A 768
LEU A 760
GLY A 811
ALA A 813
LEU A 814
 None
 1.22A 5iktB-1vbrA:
1.1		 5iktB-1vbrA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xez HEMOLYSIN

(Vibrio cholerae) 		PF07968
(Leukocidin)
PF12563
(Hemolysin_N)
PF16458
(Beta-prism_lec) 		5 VAL A 610
VAL A 711
LEU A 590
LEU A 690
LEU A 608
 None
 1.09A 5iktB-1xezA:
undetectable		 5iktB-1xezA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a35 HYPOTHETICAL PROTEIN
PA4017

(Pseudomonas
aeruginosa) 		PF08732
(HIM1) 		5 LEU A   9
LEU A  73
GLY A  12
ALA A  13
LEU A  22
 None
 1.17A 5iktB-2a35A:
undetectable		 5iktB-2a35A:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2abq FRUCTOSE 1-PHOSPHATE
KINASE

(Bacillus
halodurans) 		PF00294
(PfkB) 		5 VAL A 234
SER A 277
VAL A 251
GLY A 254
ALA A 272
 None
 1.30A 5iktB-2abqA:
undetectable		 5iktB-2abqA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3y URACIL-DNA
GLYCOSYLASE

(Thermus
thermophilus) 		PF03167
(UDG) 		5 LEU A  55
LEU A 219
GLY A 106
ALA A  51
LEU A 141
 None
 1.23A 5iktB-2d3yA:
undetectable		 5iktB-2d3yA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2elc ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N) 		5 VAL A 245
LEU A  74
GLY A 290
ALA A 289
LEU A 285
 None
 1.17A 5iktB-2elcA:
undetectable		 5iktB-2elcA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g5d GNA33

(Neisseria
gonorrhoeae) 		PF03562
(MltA)
PF06725
(3D) 		5 VAL A 404
LEU A  91
GLY A 369
ALA A 391
LEU A 372
 None
 1.28A 5iktB-2g5dA:
undetectable		 5iktB-2g5dA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hr3 PROBABLE
TRANSCRIPTIONAL
REGULATOR

(Pseudomonas
aeruginosa) 		PF13463
(HTH_27) 		5 LEU A 104
VAL A  39
GLY A  42
ALA A  43
LEU A  47
 None
 0.92A 5iktB-2hr3A:
undetectable		 5iktB-2hr3A:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iag PROSTACYCLIN
SYNTHASE

(Homo sapiens) 		PF00067
(p450) 		5 VAL A 458
LEU A 345
LEU A 485
ALA A 292
LEU A 296
 None
 1.25A 5iktB-2iagA:
undetectable		 5iktB-2iagA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o0r RV0858C
(N-SUCCINYLDIAMINOPI
MELATE
AMINOTRANSFERASE)

(Mycobacterium
tuberculosis) 		PF00155
(Aminotran_1_2) 		5 VAL A 194
LEU A  89
LEU A 261
ALA A 101
LEU A 105
 None
 1.35A 5iktB-2o0rA:
undetectable		 5iktB-2o0rA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pzi PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNG

(Mycobacterium
tuberculosis) 		PF00069
(Pkinase)
PF16918
(PknG_TPR)
PF16919
(PknG_rubred) 		5 VAL A 400
LEU A 248
LEU A 289
ALA A 255
LEU A 396
 None
 1.32A 5iktB-2pziA:
undetectable		 5iktB-2pziA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w9z G1/S-SPECIFIC
CYCLIN-D1

(Homo sapiens) 		PF00134
(Cyclin_N)
PF02984
(Cyclin_C) 		5 VAL A  67
LEU A  85
GLY A 103
ALA A 104
LEU A 124
 None
 1.35A 5iktB-2w9zA:
undetectable		 5iktB-2w9zA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3buj CALO2

(Micromonospora
echinospora) 		PF00067
(p450) 		5 VAL A 190
LEU A 106
VAL A 142
GLY A 144
LEU A 206
 None
 0.90A 5iktB-3bujA:
undetectable		 5iktB-3bujA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h09 IMMUNOGLOBULIN A1
PROTEASE

(Haemophilus
influenzae) 		PF02395
(Peptidase_S6)
PF03212
(Pertactin) 		5 VAL A 138
ARG A 169
LEU A 371
LEU A 410
GLY A 409
 None
 1.35A 5iktB-3h09A:
undetectable		 5iktB-3h09A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hv1 POLAR AMINO ACID ABC
UPTAKE TRANSPORTER
SUBSTRATE BINDING
PROTEIN

(Streptococcus
thermophilus) 		PF00497
(SBP_bac_3) 		5 VAL A 175
SER A 144
LEU A 194
GLY A 201
LEU A 172
 None
 1.14A 5iktB-3hv1A:
undetectable		 5iktB-3hv1A:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6t MUCONATE
CYCLOISOMERASE

(Jannaschia sp.
CCS1) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 LEU A 276
LEU A 303
GLY A  52
ALA A 111
LEU A 108
 None
 1.25A 5iktB-3i6tA:
undetectable		 5iktB-3i6tA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i7a PUTATIVE
METAL-DEPENDENT
PHOSPHOHYDROLASE

(Shewanella
amazonensis) 		PF08668
(HDOD) 		5 VAL A 113
LEU A  11
GLY A 159
ALA A 160
LEU A 164
 None
 1.27A 5iktB-3i7aA:
undetectable		 5iktB-3i7aA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ipo PUTATIVE THIOSULFATE
SULFURTRANSFERASE
YNJE

(Escherichia
coli) 		PF00581
(Rhodanese) 		5 VAL A 197
LEU A 292
GLY A 247
ALA A 246
LEU A 211
 None
 1.27A 5iktB-3ipoA:
undetectable		 5iktB-3ipoA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3khn MOTB PROTEIN,
PUTATIVE

(Desulfovibrio
vulgaris) 		PF00691
(OmpA) 		5 VAL A 116
SER A  51
GLY A  65
ALA A  66
LEU A  70
 None
 0.79A 5iktB-3khnA:
undetectable		 5iktB-3khnA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3khn MOTB PROTEIN,
PUTATIVE

(Desulfovibrio
vulgaris) 		PF00691
(OmpA) 		5 VAL A 116
VAL A  49
GLY A  65
ALA A  66
LEU A  70
 None
 0.83A 5iktB-3khnA:
undetectable		 5iktB-3khnA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kw2 PROBABLE R-RNA
METHYLTRANSFERASE

(Porphyromonas
gingivalis) 		PF04452
(Methyltrans_RNA) 		5 VAL A 166
LEU A  97
VAL A 232
GLY A 230
ALA A 229
 ADN  A 300 (-4.1A)
None
None
None
ADN  A 300 (-3.4A)
 1.29A 5iktB-3kw2A:
undetectable		 5iktB-3kw2A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l2z BIRA BIFUNCTIONAL
PROTEIN

(Mycobacterium
tuberculosis) 		PF02237
(BPL_C)
PF03099
(BPL_LplA_LipB) 		5 LEU A 208
LEU A 126
GLY A 106
ALA A 105
LEU A 194
 None
 1.04A 5iktB-3l2zA:
undetectable		 5iktB-3l2zA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l2z BIRA BIFUNCTIONAL
PROTEIN

(Mycobacterium
tuberculosis) 		PF02237
(BPL_C)
PF03099
(BPL_LplA_LipB) 		5 VAL A  86
LEU A 126
GLY A 106
ALA A 105
LEU A 194
 None
 0.94A 5iktB-3l2zA:
undetectable		 5iktB-3l2zA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lu2 LMO2462 PROTEIN

(Listeria
monocytogenes) 		PF01244
(Peptidase_M19) 		5 VAL A  31
LEU A  75
LEU A  93
GLY A  99
LEU A  36
 None
 1.32A 5iktB-3lu2A:
undetectable		 5iktB-3lu2A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lu2 LMO2462 PROTEIN

(Listeria
monocytogenes) 		PF01244
(Peptidase_M19) 		5 VAL A  74
LEU A  75
LEU A  93
GLY A  99
LEU A  36
 None
 1.32A 5iktB-3lu2A:
undetectable		 5iktB-3lu2A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3naf CALCIUM-ACTIVATED
POTASSIUM CHANNEL
SUBUNIT
ALPHA-1,CALCIUM-ACTI
VATED POTASSIUM
CHANNEL SUBUNIT
ALPHA-1,CALCIUM-ACTI
VATED POTASSIUM
CHANNEL SUBUNIT
ALPHA-1

(Homo sapiens) 		PF03493
(BK_channel_a) 		5 VAL A 719
LEU A 503
GLY A 492
ALA A 495
LEU A 741
 None
 1.17A 5iktB-3nafA:
undetectable		 5iktB-3nafA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o44 HEMOLYSIN

(Vibrio cholerae) 		PF07968
(Leukocidin)
PF12563
(Hemolysin_N)
PF16458
(Beta-prism_lec) 		5 VAL A 610
VAL A 711
LEU A 590
LEU A 690
LEU A 608
 None
 1.09A 5iktB-3o44A:
undetectable		 5iktB-3o44A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o85 RIBOSOMAL PROTEIN
L7AE

(Giardia
intestinalis) 		PF01248
(Ribosomal_L7Ae) 		5 VAL A  92
LEU A 107
VAL A  23
GLY A  26
ALA A  27
 None
 0.90A 5iktB-3o85A:
undetectable		 5iktB-3o85A:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s3t NUCLEOTIDE-BINDING
PROTEIN, UNIVERSAL
STRESS PROTEIN USPA
FAMILY

(Lactobacillus
plantarum) 		PF00582
(Usp) 		5 VAL A 125
SER A 132
VAL A 144
GLY A 115
ALA A 116
 None
None
None
ATP  A 501 (-3.2A)
None
 1.35A 5iktB-3s3tA:
undetectable		 5iktB-3s3tA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tpa HEME-BINDING PROTEIN
A

(Glaesserella
parasuis) 		PF00496
(SBP_bac_5) 		5 VAL A 142
VAL A  44
GLY A  56
ALA A  58
LEU A  74
 None
 1.21A 5iktB-3tpaA:
undetectable		 5iktB-3tpaA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u4j NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF00171
(Aldedh) 		5 VAL A 191
LEU A 254
VAL A 232
GLY A 230
ALA A 229
 None
 1.15A 5iktB-3u4jA:
undetectable		 5iktB-3u4jA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u6n HIGH-CONDUCTANCE
CA2+-ACTIVATED K+
CHANNEL PROTEIN

(Danio rerio) 		PF02254
(TrkA_N)
PF03493
(BK_channel_a) 		5 VAL A 723
LEU A 503
GLY A 492
ALA A 495
LEU A 745
 None
 1.09A 5iktB-3u6nA:
0.3		 5iktB-3u6nA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ua4 PROTEIN ARGININE
N-METHYLTRANSFERASE
5

(Caenorhabditis
elegans) 		PF05185
(PRMT5)
PF17285
(PRMT5_TIM)
PF17286
(PRMT5_C) 		5 VAL A 408
VAL A 393
GLY A 395
ALA A 396
LEU A 400
 None
 1.28A 5iktB-3ua4A:
undetectable		 5iktB-3ua4A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ubc HEMOGLOBIN-LIKE
FLAVOPROTEIN

(Methylacidiphilum
infernorum) 		PF00042
(Globin) 		5 VAL A  57
LEU A  58
TRP A 119
ALA A 126
LEU A  75
 HEM  A 201 (-4.6A)
None
None
HEM  A 201 ( 3.9A)
None
 1.26A 5iktB-3ubcA:
undetectable		 5iktB-3ubcA:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wai MALTOSE-BINDING
PERIPLASMIC PROTEIN,
TRANSMEMBRANE
OLIGOSACCHARYL
TRANSFERASE

(Escherichia
coli;
Archaeoglobus
fulgidus) 		PF13416
(SBP_bac_8) 		5 VAL A 343
LEU A 160
GLY A 187
ALA A 188
LEU A 361
 None
 1.26A 5iktB-3waiA:
undetectable		 5iktB-3waiA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x0y DSZC

(Rhodococcus
erythropolis) 		PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N)
PF08028
(Acyl-CoA_dh_2) 		5 SER A 217
LEU A  93
GLY A 164
ALA A 165
LEU A 171
 None
 1.22A 5iktB-3x0yA:
undetectable		 5iktB-3x0yA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x0y DSZC

(Rhodococcus
erythropolis) 		PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N)
PF08028
(Acyl-CoA_dh_2) 		5 VAL A 199
LEU A  93
GLY A 164
ALA A 165
LEU A 171
 None
 1.14A 5iktB-3x0yA:
undetectable		 5iktB-3x0yA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4akk NITRATE REGULATORY
PROTEIN

(Klebsiella
oxytoca) 		PF03861
(ANTAR)
PF08376
(NIT) 		5 ARG A 115
MET A  45
VAL A  75
GLY A  71
ALA A  72
 EDO  A1394 (-4.0A)
None
None
None
None
 1.14A 5iktB-4akkA:
undetectable		 5iktB-4akkA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dwq TRNA-SPLICING LIGASE
RTCB

(Pyrococcus
horikoshii) 		PF01139
(RtcB) 		5 VAL A 147
LEU A 148
GLY A 191
ALA A 192
LEU A 139
 None
 1.08A 5iktB-4dwqA:
undetectable		 5iktB-4dwqA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4efc ADENYLOSUCCINATE
LYASE

(Trypanosoma
brucei) 		PF00206
(Lyase_1)
PF08328
(ASL_C) 		5 LEU A 379
SER A 376
LEU A 173
TRP A 176
LEU A 205
 None
 1.15A 5iktB-4efcA:
undetectable		 5iktB-4efcA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gew 5'-TYROSYL-DNA
PHOSPHODIESTERASE

(Caenorhabditis
elegans) 		PF03372
(Exo_endo_phos)
PF14555
(UBA_4) 		5 VAL A 226
VAL A 122
LEU A 272
GLY A 269
LEU A 228
 None
 1.06A 5iktB-4gewA:
undetectable		 5iktB-4gewA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ifp MALTOSE-BINDING
PERIPLASMIC
PROTEIN,NACHT, LRR
AND PYD
DOMAINS-CONTAINING
PROTEIN 1

(Escherichia
coli;
Homo sapiens) 		PF00619
(CARD)
PF13416
(SBP_bac_8) 		5 VAL A 344
LEU A 161
GLY A 188
ALA A 189
LEU A 362
 None
 1.18A 5iktB-4ifpA:
undetectable		 5iktB-4ifpA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k2x POLYKETIDE
OXYGENASE/HYDROXYLAS
E

(Streptomyces
rimosus) 		PF01494
(FAD_binding_3) 		5 VAL A 135
LEU A 126
LEU A 285
GLY A 153
ALA A   8
 None
None
None
None
FAD  A 601 ( 4.3A)
 1.24A 5iktB-4k2xA:
undetectable		 5iktB-4k2xA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l35 CRUXRHODOPSIN-3

(Haloarcula
vallismortis) 		PF01036
(Bac_rhodopsin) 		5 VAL A 185
LEU A 228
VAL A 221
GLY A 224
LEU A 181
 None
 1.36A 5iktB-4l35A:
undetectable		 5iktB-4l35A:
18.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ph9 PROSTAGLANDIN G/H
SYNTHASE 2

(Mus musculus) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		10 VAL A 117
ARG A 121
VAL A 350
LEU A 385
TRP A 388
MET A 523
VAL A 524
GLY A 527
ALA A 528
LEU A 532
 BOG  A 604 (-3.9A)
BOG  A 604 ( 3.7A)
IBP  A 601 (-4.3A)
None
None
None
IBP  A 601 ( 4.0A)
IBP  A 601 (-3.9A)
IBP  A 601 (-3.4A)
IBP  A 601 ( 4.9A)
 0.39A 5iktB-4ph9A:
63.1		 5iktB-4ph9A:
88.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ph9 PROSTAGLANDIN G/H
SYNTHASE 2

(Mus musculus) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		11 VAL A 117
VAL A 350
LEU A 353
SER A 354
LEU A 385
TRP A 388
MET A 523
VAL A 524
GLY A 527
ALA A 528
LEU A 532
 BOG  A 604 (-3.9A)
IBP  A 601 (-4.3A)
IBP  A 601 ( 4.7A)
None
None
None
None
IBP  A 601 ( 4.0A)
IBP  A 601 (-3.9A)
IBP  A 601 (-3.4A)
IBP  A 601 ( 4.9A)
 0.33A 5iktB-4ph9A:
63.1		 5iktB-4ph9A:
88.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4phz PARTICULATE METHANE
MONOOXYGENASE
SUBUNIT C

(Methylocystis
sp. ATCC 49242) 		no annotation 5 VAL K 234
LEU K  80
GLY K 163
ALA K 164
LEU K 111
 None
PGT  K 302 (-4.6A)
PGT  K 302 (-3.7A)
None
None
 1.14A 5iktB-4phzK:
undetectable		 5iktB-4phzK:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tx2 NON-RIBOSOMAL
PEPTIDE SYNTHETASE

(Actinoplanes
teichomyceticus) 		PF00668
(Condensation) 		5 VAL B  61
VAL B 139
LEU B  39
GLY B 300
LEU B  68
 None
 0.94A 5iktB-4tx2B:
undetectable		 5iktB-4tx2B:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ubs PENTALENIC ACID
SYNTHASE

(Streptomyces
avermitilis) 		PF00067
(p450) 		5 VAL A 400
LEU A 285
MET A 249
GLY A 253
LEU A 258
 None
None
HEM  A 501 (-4.4A)
None
None
 1.28A 5iktB-4ubsA:
undetectable		 5iktB-4ubsA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4umv ZINC-TRANSPORTING
ATPASE

(Shigella sonnei) 		PF00122
(E1-E2_ATPase)
PF00702
(Hydrolase) 		5 VAL A 228
MET A 625
GLY A 627
ALA A 644
LEU A 653
 None
 1.34A 5iktB-4umvA:
undetectable		 5iktB-4umvA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yk6 ADENOMATOUS
POLYPOSIS COLI
PROTEIN

(Homo sapiens) 		PF00514
(Arm)
PF16629
(Arm_APC_u3) 		5 VAL A 642
VAL A 609
GLY A 611
ALA A 612
LEU A 616
 None
 1.00A 5iktB-4yk6A:
0.0		 5iktB-4yk6A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z8z UNCHARACTERIZED
PROTEIN

(Ruminiclostridium
thermocellum) 		no annotation 5 VAL A 237
VAL A 219
LEU A 225
ALA A 150
LEU A 152
 None
 1.10A 5iktB-4z8zA:
undetectable		 5iktB-4z8zA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zoy SQT1

(Chaetomium
thermophilum) 		PF00400
(WD40) 		5 LEU A 289
SER A 288
LEU A 371
GLY A 327
ALA A 367
 None
 1.22A 5iktB-4zoyA:
undetectable		 5iktB-4zoyA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dgq PUTATIVE
ENDOGLUCANASE-RELATE
D PROTEIN

(Photobacterium
profundum) 		PF00759
(Glyco_hydro_9) 		5 VAL A 320
LEU A 399
MET A 460
ALA A 378
LEU A 316
 None
 1.23A 5iktB-5dgqA:
undetectable		 5iktB-5dgqA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ex6 CYTOCHROME P450

(Streptomyces
toyocaensis) 		no annotation 5 VAL C 396
LEU C 280
MET C 244
GLY C 248
LEU C 253
 None
 1.18A 5iktB-5ex6C:
undetectable		 5iktB-5ex6C:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fif CARBOXYLASE

(Deinococcus
radiodurans) 		PF01039
(Carboxyl_trans) 		5 VAL A 102
LEU A 191
GLY A 146
ALA A 145
LEU A 141
 None
 1.35A 5iktB-5fifA:
undetectable		 5iktB-5fifA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikl GERANYL-COA
CARBOXYLASE,
BETA-SUBUNIT

(Pseudomonas
aeruginosa) 		PF01039
(Carboxyl_trans) 		5 VAL B 444
VAL B 453
GLY B 451
ALA B 450
LEU B 485
 None
 1.02A 5iktB-5iklB:
undetectable		 5iktB-5iklB:
22.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ikr PROSTAGLANDIN G/H
SYNTHASE 2

(Homo sapiens) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		12 VAL A 116
ARG A 120
VAL A 349
LEU A 352
SER A 353
LEU A 384
TRP A 387
MET A 522
VAL A 523
GLY A 526
ALA A 527
LEU A 531
 None
ID8  A 601 ( 4.4A)
ID8  A 601 (-3.9A)
ID8  A 601 (-4.1A)
ID8  A 601 ( 4.7A)
ID8  A 601 ( 4.8A)
COH  A 602 (-4.5A)
ID8  A 601 (-4.2A)
ID8  A 601 (-3.6A)
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
 0.20A 5iktB-5ikrA:
64.8		 5iktB-5ikrA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5in8 ARISTOLOCHENE
SYNTHASE

(Aspergillus
terreus) 		no annotation 5 VAL A 272
LEU A 275
SER A 276
LEU A 190
ALA A 286
 None
 0.75A 5iktB-5in8A:
undetectable		 5iktB-5in8A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5it1 PUTATIVE CYTOCHROME
P450

(Streptomyces
peucetius) 		PF00067
(p450) 		5 VAL A 397
LEU A 281
MET A 245
GLY A 249
LEU A 254
 None
None
HEM  A 401 ( 4.4A)
None
None
 1.20A 5iktB-5it1A:
undetectable		 5iktB-5it1A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iva LPS-ASSEMBLY PROTEIN
LPTD

(Pseudomonas
aeruginosa) 		PF04453
(OstA_C) 		5 SER A 408
LEU A 384
VAL A 406
GLY A 424
ALA A 423
 None
 1.03A 5iktB-5ivaA:
undetectable		 5iktB-5ivaA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5khn RND TRANSPORTER

(Burkholderia
multivorans) 		no annotation 5 VAL B 765
VAL B 464
GLY B 467
ALA B 468
LEU B 471
 None
 0.94A 5iktB-5khnB:
undetectable		 5iktB-5khnB:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kk5 CRISPR-ASSOCIATED
ENDONUCLEASE CPF1

(Acidaminococcus
sp. BV3L6) 		no annotation 5 LEU A 310
SER A 311
LEU A 132
ALA A  62
LEU A  66
 None
 1.31A 5iktB-5kk5A:
undetectable		 5iktB-5kk5A:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lae PEROXISOMAL
N(1)-ACETYL-SPERMINE
/SPERMIDINE
OXIDASE,PEROXISOMAL
N(1)-ACETYL-SPERMINE
/SPERMIDINE OXIDASE

(Mus musculus) 		PF01593
(Amino_oxidase) 		5 VAL A   8
LEU A 479
GLY A  19
ALA A  20
LEU A  24
 None
 0.95A 5iktB-5laeA:
undetectable		 5iktB-5laeA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mek CYTOSOLIC
SULFOTRANSFERASE 18

(Arabidopsis
thaliana) 		PF00685
(Sulfotransfer_1) 		5 VAL A 274
ARG A 109
VAL A 254
LEU A 257
LEU A 151
 None
EDO  A 415 ( 3.7A)
None
None
None
 1.20A 5iktB-5mekA:
undetectable		 5iktB-5mekA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mzo UDP-GLUCOSE-GLYCOPRO
TEIN
GLUCOSYLTRANSFERASE-
LIKE PROTEIN

(Chaetomium
thermophilum) 		PF06427
(UDP-g_GGTase) 		5 VAL A 865
LEU A 849
GLY A 391
ALA A 394
LEU A 398
 None
 1.26A 5iktB-5mzoA:
undetectable		 5iktB-5mzoA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nsq AMINOPEPTIDASE,
PUTATIVE

(Trypanosoma
brucei) 		PF00883
(Peptidase_M17) 		5 LEU A 378
LEU A 496
GLY A 315
ALA A 316
LEU A 339
 None
 1.22A 5iktB-5nsqA:
undetectable		 5iktB-5nsqA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nsq AMINOPEPTIDASE,
PUTATIVE

(Trypanosoma
brucei) 		PF00883
(Peptidase_M17) 		5 VAL A 270
LEU A 378
LEU A 496
GLY A 315
ALA A 316
 None
 1.29A 5iktB-5nsqA:
undetectable		 5iktB-5nsqA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uld TRANSPORTER, NADC
FAMILY

(Vibrio cholerae) 		PF00939
(Na_sulph_symp) 		5 LEU A 270
VAL A 295
GLY A 298
ALA A 299
LEU A 106
 None
 1.27A 5iktB-5uldA:
0.0		 5iktB-5uldA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uvd NUCLEOTIDYLTRANSFERA
SE-LIKE PROTEIN

(Paracoccidioides
brasiliensis) 		no annotation 5 VAL A 135
LEU A   4
GLY A  32
ALA A  33
LEU A  37
 None
None
MG  A 302 ( 4.7A)
None
None
 1.03A 5iktB-5uvdA:
undetectable		 5iktB-5uvdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w7q CONSENSUS ELONGATION
FACTOR

(synthetic
construct) 		no annotation 5 VAL A 243
VAL A 259
GLY A 275
ALA A 276
LEU A 278
 None
 1.26A 5iktB-5w7qA:
undetectable		 5iktB-5w7qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wq6 MBP TAGGED HMNDA-PYD

(Homo sapiens) 		PF02758
(PYRIN)
PF13416
(SBP_bac_8) 		5 VAL A 344
LEU A 161
GLY A 188
ALA A 189
LEU A 362
 None
 1.23A 5iktB-5wq6A:
undetectable		 5iktB-5wq6A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xjy ATP-BINDING CASSETTE
SUB-FAMILY A MEMBER
1

(Homo sapiens) 		PF00005
(ABC_tran)
PF12698
(ABC2_membrane_3) 		5 VAL A1769
VAL A1673
LEU A1676
TRP A1699
ALA A1756
 None
 1.19A 5iktB-5xjyA:
undetectable		 5iktB-5xjyA:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yem CATALASE

(Mycothermus
thermophilus) 		no annotation 5 LEU A 564
VAL A 610
GLY A 612
ALA A 613
LEU A 616
 None
 1.30A 5iktB-5yemA:
undetectable		 5iktB-5yemA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z96 SHORT TRANSIENT
RECEPTOR POTENTIAL
CHANNEL 4

(Mus musculus) 		no annotation 5 LEU A  83
VAL A 109
GLY A 110
ALA A 111
LEU A 100
 None
 1.08A 5iktB-5z96A:
undetectable		 5iktB-5z96A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zt3 WA352

(Oryza sativa) 		no annotation 5 ARG A  82
SER A  26
MET A  77
GLY A  80
ALA A  81
 None
 1.35A 5iktB-5zt3A:
undetectable		 5iktB-5zt3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zvt C-TERMINUS OF OUTER
CAPSID PROTEIN VP5

(Aquareovirus C) 		no annotation 5 VAL B 353
LEU B 444
GLY B 401
ALA B 400
LEU B 422
 None
 1.08A 5iktB-5zvtB:
undetectable		 5iktB-5zvtB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bar ROD SHAPE
DETERMINING PROTEIN
RODA

(Thermus
thermophilus) 		no annotation 5 LEU A 181
LEU A 327
GLY A 154
ALA A 156
LEU A 148
 None
 1.30A 5iktB-6barA:
undetectable		 5iktB-6barA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bar ROD SHAPE
DETERMINING PROTEIN
RODA

(Thermus
thermophilus) 		no annotation 5 LEU A 181
LEU A 327
GLY A 155
ALA A 156
LEU A 148
 None
 1.10A 5iktB-6barA:
undetectable		 5iktB-6barA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c5c 3-DEHYDROQUINATE
SYNTHASE

(Candida
albicans) 		no annotation 5 VAL A 170
LEU A   9
VAL A 247
GLY A 245
ALA A 244
 None
 1.32A 5iktB-6c5cA:
undetectable		 5iktB-6c5cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c8z ADP-DEPENDENT
PHOSPHOFRUCTOKINASE

(Methanosarcinales) 		no annotation 5 VAL A 266
LEU A 482
GLY A 237
ALA A 238
LEU A 240
 None
 1.16A 5iktB-6c8zA:
undetectable		 5iktB-6c8zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ch3 FLAGELLAR SECRETION
CHAPERONE
FLIS,FLAGELLIN

(Salmonella
enterica) 		no annotation 5 VAL B 111
LEU B 197
GLY B  34
ALA B  35
LEU B  39
 None
 1.09A 5iktB-6ch3B:
1.2		 5iktB-6ch3B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dm8 -

(-) 		no annotation 5 VAL A 128
LEU A -55
GLY A -28
ALA A -27
LEU A 146
 None
 1.25A 5iktB-6dm8A:
undetectable		 5iktB-6dm8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fn1 HUMAN-MOUSE CHIMERIC
ABCB1 (ABCBHM)

(Homo sapiens) 		no annotation 5 VAL A1059
VAL A1078
LEU A1081
VAL A1093
LEU A1057
 None
 1.00A 5iktB-6fn1A:
undetectable		 5iktB-6fn1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fsh OXYB PROTEIN

(Actinoplanes
teichomyceticus) 		no annotation 5 VAL A 396
LEU A 280
MET A 244
GLY A 248
LEU A 253
 None
 1.28A 5iktB-6fshA:
undetectable		 5iktB-6fshA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1adq IGM-LAMBDA RF-AN FAB
(HEAVY CHAIN)

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 TYR H  90
TYR H 185
SER H 112
 None
 1.00A 5iktB-1adqH:
0.0		 5iktB-1adqH:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bou 4,5-DIOXYGENASE
ALPHA CHAIN
4,5-DIOXYGENASE BETA
CHAIN

(Sphingomonas
paucimobilis;
Sphingomonas
paucimobilis) 		PF07746
(LigA)
PF02900
(LigB) 		3 TYR A 118
TYR B 264
SER B 194
 None
 1.00A 5iktB-1bouA:
undetectable		 5iktB-1bouA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c4p PROTEIN
(STREPTOKINASE)

(Streptococcus
dysgalactiae) 		PF02821
(Staphylokinase) 		3 TYR A 275
TYR A 162
SER A 222
 None
 0.97A 5iktB-1c4pA:
undetectable		 5iktB-1c4pA:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fcd FLAVOCYTOCHROME C
SULFIDE
DEHYDROGENASE
(FLAVIN-BINDING
SUBUNIT)

(Allochromatium
vinosum) 		PF07992
(Pyr_redox_2)
PF09242
(FCSD-flav_bind) 		3 TYR A 338
TYR A 353
SER A 307
 None
 0.85A 5iktB-1fcdA:
0.0		 5iktB-1fcdA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fcp PROTEIN (FERRIC
HYDROXAMATE UPTAKE
RECEPTOR)

(Escherichia
coli) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		3 TYR A 243
TYR A 664
SER A 700
 None
 0.83A 5iktB-1fcpA:
0.0		 5iktB-1fcpA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hxj BETA-GLUCOSIDASE

(Zea mays) 		PF00232
(Glyco_hydro_1) 		3 TYR A 163
TYR A 117
SER A  93
 None
 0.98A 5iktB-1hxjA:
0.0		 5iktB-1hxjA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l5j ACONITATE HYDRATASE
2

(Escherichia
coli) 		PF00330
(Aconitase)
PF06434
(Aconitase_2_N)
PF11791
(Aconitase_B_N) 		3 TYR A 754
TYR A 448
SER A 770
 None
 0.76A 5iktB-1l5jA:
0.0		 5iktB-1l5jA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l9y FEZ-1 B-LACTAMASE

(Fluoribacter
gormanii) 		PF00753
(Lactamase_B) 		3 TYR A  36
TYR A 293
SER A 221
 None
 0.95A 5iktB-1l9yA:
0.0		 5iktB-1l9yA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r1n FERRIC-IRON BINDING
PROTEIN

(Neisseria
gonorrhoeae) 		PF01547
(SBP_bac_1) 		3 TYR A 196
TYR A  55
SER A 228
 CNB  A 400 (-3.7A)
None
None
 0.90A 5iktB-1r1nA:
0.0		 5iktB-1r1nA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rpt PROSTATIC ACID
PHOSPHATASE

(Rattus
norvegicus) 		PF00328
(His_Phos_2) 		3 TYR A 182
TYR A 299
SER A 280
 None
 0.96A 5iktB-1rptA:
undetectable		 5iktB-1rptA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sde D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE

(Streptomyces
sp. R61) 		PF00144
(Beta-lactamase) 		3 TYR A 159
TYR A 198
SER A  68
 2PB  A 400 (-4.2A)
None
None
 1.00A 5iktB-1sdeA:
undetectable		 5iktB-1sdeA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1txk GLUCANS BIOSYNTHESIS
PROTEIN G

(Escherichia
coli) 		PF04349
(MdoG) 		3 TYR A  40
TYR A 218
SER A 155
 None
 0.90A 5iktB-1txkA:
undetectable		 5iktB-1txkA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tzq EQUINATOXIN II

(Actinia equina) 		PF06369
(Anemone_cytotox) 		3 TYR A 110
TYR A 133
SER A  54
 None
 0.61A 5iktB-1tzqA:
undetectable		 5iktB-1tzqA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v02 DHURRINASE

(Sorghum bicolor) 		PF00232
(Glyco_hydro_1) 		3 TYR A 166
TYR A 123
SER A  99
 None
 0.99A 5iktB-1v02A:
0.0		 5iktB-1v02A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE

(Thermotoga
maritima) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		3 TYR A  12
TYR A 199
SER A 174
 None
 0.70A 5iktB-1vknA:
undetectable		 5iktB-1vknA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xoc OLIGOPEPTIDE-BINDING
PROTEIN APPA

(Bacillus
subtilis) 		PF00496
(SBP_bac_5) 		3 TYR A 135
TYR A 207
SER A 185
 None
 0.77A 5iktB-1xocA:
undetectable		 5iktB-1xocA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xss FLUORESCENT PROTEIN

(Favia favus) 		PF01353
(GFP) 		3 TYR A 119
TYR A  78
SER A  82
 DYG  A  64 ( 4.8A)
None
None
 0.99A 5iktB-1xssA:
undetectable		 5iktB-1xssA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zcz BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH

(Thermotoga
maritima) 		PF01808
(AICARFT_IMPCHas)
PF02142
(MGS) 		3 TYR A 273
TYR A 171
SER A 197
 None
 0.99A 5iktB-1zczA:
undetectable		 5iktB-1zczA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cvo PUTATIVE
SEMIALDEHYDE
DEHYDROGENASE

(Oryza sativa) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		3 TYR A  83
TYR A 273
SER A 248
 None
 0.70A 5iktB-2cvoA:
undetectable		 5iktB-2cvoA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2egu CYSTEINE SYNTHASE

(Geobacillus
kaustophilus) 		PF00291
(PALP) 		3 TYR A 110
TYR A 298
SER A  43
 None
 0.98A 5iktB-2eguA:
undetectable		 5iktB-2eguA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g17 N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE

(Salmonella
enterica) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		3 TYR A  12
TYR A 207
SER A 184
 SO4  A 405 (-4.6A)
SO4  A 410 ( 4.7A)
None
 0.82A 5iktB-2g17A:
undetectable		 5iktB-2g17A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gas ISOFLAVONE REDUCTASE

(Medicago sativa) 		PF05368
(NmrA) 		3 TYR A 288
TYR A 307
SER A 299
 None
 0.90A 5iktB-2gasA:
undetectable		 5iktB-2gasA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gfi PHYTASE

(Debaryomyces
castellii) 		PF00328
(His_Phos_2) 		3 TYR A  77
TYR A 111
SER A 272
 None
 0.91A 5iktB-2gfiA:
undetectable		 5iktB-2gfiA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gsk VITAMIN B12
TRANSPORTER BTUB

(Escherichia
coli) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		3 TYR A 296
TYR A 221
SER A 247
 None
 0.96A 5iktB-2gskA:
undetectable		 5iktB-2gskA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i3a N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE

(Mycobacterium
tuberculosis) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		3 TYR A  20
TYR A 211
SER A 186
 None
 0.77A 5iktB-2i3aA:
undetectable		 5iktB-2i3aA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i7t CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
73 KDA SUBUNIT

(Homo sapiens) 		PF00753
(Lactamase_B)
PF07521
(RMMBL)
PF10996
(Beta-Casp) 		3 TYR A 357
TYR A 176
SER A  26
 None
 0.95A 5iktB-2i7tA:
undetectable		 5iktB-2i7tA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jvu DISPERSIN

(Escherichia
coli) 		no annotation 3 TYR A  23
TYR A  52
SER A  58
 None
 0.92A 5iktB-2jvuA:
undetectable		 5iktB-2jvuA:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jyz CG7054-PA

(Drosophila
melanogaster) 		PF01161
(PBP) 		3 TYR A  73
TYR A 166
SER A 103
 None
 0.81A 5iktB-2jyzA:
undetectable		 5iktB-2jyzA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o8r POLYPHOSPHATE KINASE

(Porphyromonas
gingivalis) 		PF02503
(PP_kinase)
PF13089
(PP_kinase_N)
PF13090
(PP_kinase_C) 		3 TYR A  51
TYR A  97
SER A 295
 None
SO4  A 705 (-4.5A)
None
 0.96A 5iktB-2o8rA:
undetectable		 5iktB-2o8rA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2otb GFP-LIKE FLUORESCENT
CHROMOPROTEIN CFP484

(Clavularia sp.) 		PF01353
(GFP) 		3 TYR A 120
TYR A  82
SER A  86
 PIA  A  66 ( 4.7A)
None
None
 0.98A 5iktB-2otbA:
undetectable		 5iktB-2otbA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pbg 6-PHOSPHO-BETA-D-GAL
ACTOSIDASE

(Lactococcus
lactis) 		PF00232
(Glyco_hydro_1) 		3 TYR A  53
TYR A 141
SER A  78
 None
 0.87A 5iktB-2pbgA:
0.1		 5iktB-2pbgA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q49 PROBABLE
N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE

(Arabidopsis
thaliana) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		3 TYR A  27
TYR A 217
SER A 192
 None
 0.77A 5iktB-2q49A:
undetectable		 5iktB-2q49A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q6z UROPORPHYRINOGEN
DECARBOXYLASE

(Homo sapiens) 		PF01208
(URO-D) 		3 TYR A 342
TYR A 164
SER A 219
 None
 0.75A 5iktB-2q6zA:
undetectable		 5iktB-2q6zA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yhg CELLULOSE-BINDING
PROTEIN

(Saccharophagus
degradans) 		PF07632
(DUF1593) 		3 TYR A 707
TYR A 730
SER A 542
 None
 0.98A 5iktB-2yhgA:
0.5		 5iktB-2yhgA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zyv TYROSINE-ESTER
SULFOTRANSFERASE

(Mus musculus) 		PF00685
(Sulfotransfer_1) 		3 TYR X 280
TYR X 127
SER X  49
 None
 1.00A 5iktB-2zyvX:
undetectable		 5iktB-2zyvX:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aiv BETA-GLUCOSIDASE

(Secale cereale) 		PF00232
(Glyco_hydro_1) 		3 TYR A 168
TYR A 125
SER A 103
 None
 0.98A 5iktB-3aivA:
0.0		 5iktB-3aivA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b1e BETAC-S LYASE

(Streptococcus
anginosus) 		PF00155
(Aminotran_1_2) 		3 TYR A 322
TYR A 281
SER A 230
 None
 0.99A 5iktB-3b1eA:
undetectable		 5iktB-3b1eA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c5h GLUCOCORTICOID
RECEPTOR DNA-BINDING
FACTOR 1

(Homo sapiens) 		PF00071
(Ras) 		3 TYR A 116
TYR A 133
SER A  36
 None
None
MG  A 302 ( 2.1A)
 0.94A 5iktB-3c5hA:
undetectable		 5iktB-3c5hA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gdn R-OXYNITRILE LYASE
ISOENZYME 1

(Prunus dulcis) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		3 TYR A  11
TYR A 147
SER A   5
 None
 0.80A 5iktB-3gdnA:
undetectable		 5iktB-3gdnA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9v NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 3
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 4
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 5

(Thermus
thermophilus;
Thermus
thermophilus;
Thermus
thermophilus) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4)
PF10588
(NADH-G_4Fe-4S_3)
PF13510
(Fer2_4)
PF00346
(Complex1_49kDa)
PF00329
(Complex1_30kDa) 		3 TYR 4 326
TYR 3 143
SER 5 194
 None
 0.79A 5iktB-3i9v4:
undetectable		 5iktB-3i9v4:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3juj UDP-GLUCOSE
PYROPHOSPHORYLASE
(GALU)

(Helicobacter
pylori) 		PF00483
(NTP_transferase) 		3 TYR A 268
TYR A  65
SER A  87
 None
 0.98A 5iktB-3jujA:
undetectable		 5iktB-3jujA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ke7 PUTATIVE KETOSTEROID
ISOMERASE

(Parabacteroides
distasonis) 		PF13474
(SnoaL_3) 		3 TYR A  84
TYR A 149
SER A  69
 BCN  A   2 (-4.7A)
None
None
 0.95A 5iktB-3ke7A:
undetectable		 5iktB-3ke7A:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lim FRAGACEATOXIN C

(Actinia
fragacea) 		PF06369
(Anemone_cytotox) 		3 TYR A 110
TYR A 133
SER A  54
 None
LDA  A 201 (-4.4A)
LDA  A 201 ( 4.9A)
 0.50A 5iktB-3limA:
undetectable		 5iktB-3limA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qvu SULFOTRANSFERASE 1A1

(Homo sapiens) 		PF00685
(Sulfotransfer_1) 		3 TYR A 280
TYR A 127
SER A  49
 None
 0.98A 5iktB-3qvuA:
undetectable		 5iktB-3qvuA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r5x D-ALANINE--D-ALANINE
LIGASE

(Bacillus
anthracis) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		3 TYR A  33
TYR A 244
SER A  82
 None
 0.90A 5iktB-3r5xA:
undetectable		 5iktB-3r5xA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r5x D-ALANINE--D-ALANINE
LIGASE

(Bacillus
anthracis) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		3 TYR A  33
TYR A 244
SER A 295
 None
 0.90A 5iktB-3r5xA:
undetectable		 5iktB-3r5xA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3red HYDROXYNITRILE LYASE

(Prunus mume) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		3 TYR A  11
TYR A 147
SER A   5
 None
 0.87A 5iktB-3redA:
undetectable		 5iktB-3redA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u9p NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN

(Mus musculus) 		PF00061
(Lipocalin) 		3 TYR C  96
TYR C  50
SER C  62
 None
 0.73A 5iktB-3u9pC:
undetectable		 5iktB-3u9pC:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uca GERANYLTRANSTRANSFER
ASE

(Clostridium
perfringens) 		PF00348
(polyprenyl_synt) 		3 TYR A  66
TYR A 135
SER A 142
 None
 0.98A 5iktB-3ucaA:
undetectable		 5iktB-3ucaA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3va6 TWO-COMPONENT SYSTEM
SENSOR HISTIDINE
KINASE

(Bacteroides
thetaiotaomicron) 		PF07494
(Reg_prop)
PF07495
(Y_Y_Y) 		3 TYR A 669
TYR A 114
SER A  72
 None
 0.97A 5iktB-3va6A:
undetectable		 5iktB-3va6A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vrd FLAVOCYTOCHROME C
FLAVIN SUBUNIT

(Thermochromatium
tepidum) 		PF07992
(Pyr_redox_2)
PF09242
(FCSD-flav_bind) 		3 TYR B 338
TYR B 353
SER B 307
 HEC  A 201 ( 4.8A)
None
None
 0.94A 5iktB-3vrdB:
undetectable		 5iktB-3vrdB:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zul FLUORESCENT PROTEIN
DRONPA

(Echinophyllia
sp. SC22) 		PF01353
(GFP) 		3 TYR A 116
TYR A  78
SER A  82
 GYC  A  63 ( 4.8A)
None
None
 0.96A 5iktB-3zulA:
undetectable		 5iktB-3zulA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d7w SORTASE FAMILY
PROTEIN

(Streptococcus
agalactiae) 		PF04203
(Sortase) 		3 TYR A 181
TYR A  88
SER A 133
 None
 0.80A 5iktB-4d7wA:
undetectable		 5iktB-4d7wA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ddd IMMUNOGENIC PROTEIN

(Ehrlichia
chaffeensis) 		PF16868
(NMT1_3) 		3 TYR A 237
TYR A  43
SER A  74
 None
GOL  A 405 (-3.8A)
CL  A 401 (-3.2A)
 0.95A 5iktB-4dddA:
undetectable		 5iktB-4dddA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dn7 ABC TRANSPORTER,
ATP-BINDING PROTEIN

(Methanosarcina
mazei) 		PF01458
(UPF0051) 		3 TYR A 234
TYR A 130
SER A 192
 None
 0.99A 5iktB-4dn7A:
undetectable		 5iktB-4dn7A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ghb HYPOTHETICAL PROTEIN

(Bacteroides
uniformis) 		PF15283
(DUF4595) 		3 TYR A 236
TYR A 135
SER A 148
 None
None
GOL  A 414 ( 4.0A)
 0.99A 5iktB-4ghbA:
undetectable		 5iktB-4ghbA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hxe PUTATIVE
UNCHARACTERIZED
PROTEIN PH0594

(Pyrococcus
horikoshii) 		PF00326
(Peptidase_S9)
PF07676
(PD40) 		3 TYR B 392
TYR B 593
SER B 581
 None
 0.96A 5iktB-4hxeB:
undetectable		 5iktB-4hxeB:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kf5 FLUORESCENT PROTEIN
SFCHERRY+GFP10-11

(synthetic
construct) 		PF01353
(GFP) 		3 TYR C 120
TYR C  82
SER C  86
 CH6  C  66 ( 4.3A)
None
None
 1.01A 5iktB-4kf5C:
undetectable		 5iktB-4kf5C:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4knk BIFUNCTIONAL
AUTOLYSIN

(Staphylococcus
aureus) 		PF01510
(Amidase_2) 		3 TYR A 341
TYR A 252
SER A 309
 None
 0.97A 5iktB-4knkA:
undetectable		 5iktB-4knkA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l22 PHOSPHORYLASE

(Streptococcus
mutans) 		PF00343
(Phosphorylase) 		3 TYR A 228
TYR A 314
SER A 283
 None
 0.98A 5iktB-4l22A:
undetectable		 5iktB-4l22A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l37 ARYLPHORIN

(Bombyx mori) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		3 TYR B  85
TYR B 415
SER B 405
 None
 0.58A 5iktB-4l37B:
undetectable		 5iktB-4l37B:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l37 SILKWORM STORAGE
PROTEIN

(Bombyx mori) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		3 TYR A  82
TYR A 412
SER A 402
 None
 0.60A 5iktB-4l37A:
undetectable		 5iktB-4l37A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n78 CYTOPLASMIC
FMR1-INTERACTING
PROTEIN 1

(Homo sapiens) 		PF05994
(FragX_IP)
PF07159
(DUF1394) 		3 TYR A 443
TYR A 671
SER A 667
 None
 0.96A 5iktB-4n78A:
undetectable		 5iktB-4n78A:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o9g QDTA

(Thermoanaerobacterium
thermosaccharolyticum) 		PF05523
(FdtA) 		3 TYR A 121
TYR A  90
SER A 113
 T46  A 201 (-4.3A)
None
None
 0.96A 5iktB-4o9gA:
undetectable		 5iktB-4o9gA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4odh CAP256-VRC26.UCA
HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 TYR H  90
TYR H 176
SER H 112
 None
 0.83A 5iktB-4odhH:
undetectable		 5iktB-4odhH:
17.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ph9 PROSTAGLANDIN G/H
SYNTHASE 2

(Mus musculus) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		3 TYR A 356
TYR A 386
SER A 531
 IBP  A 601 (-4.5A)
IBP  A 601 (-4.8A)
IBP  A 601 ( 3.3A)
 0.83A 5iktB-4ph9A:
63.1		 5iktB-4ph9A:
88.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qlj BETA-GLUCOSIDASE 7

(Oryza sativa) 		PF00232
(Glyco_hydro_1) 		3 TYR A 131
TYR A  85
SER A 434
 None
 0.88A 5iktB-4qljA:
undetectable		 5iktB-4qljA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4re2 BETA-MANNOSIDASE/BET
A-GLUCOSIDASE

(Oryza sativa) 		PF00232
(Glyco_hydro_1) 		3 TYR A 134
TYR A  88
SER A 437
 MVL  A 501 (-4.7A)
None
None
 0.73A 5iktB-4re2A:
0.0		 5iktB-4re2A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rwf MALTOSE TRANSPORTER
SUBUNIT, RECEPTOR
ACTIVITY-MODIFYING
PROTEIN 2,
CALCITONIN
GENE-RELATED PEPTIDE
TYPE 1 RECEPTOR
FUSION PROTEIN
ADRENOMEDULLIN

(Escherichia
coli;
Homo sapiens;
Homo sapiens) 		PF02793
(HRM)
PF04901
(RAMP)
PF13416
(SBP_bac_8)
PF00214
(Calc_CGRP_IAPP) 		3 TYR A 343
TYR B  52
SER B  45
 None
 0.85A 5iktB-4rwfA:
undetectable		 5iktB-4rwfA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s0v HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE

(Homo sapiens;
Pyrococcus
abyssi) 		PF00001
(7tm_1)
PF00534
(Glycos_transf_1) 		3 TYR A 364
TYR A 317
SER A 141
 None
 0.92A 5iktB-4s0vA:
undetectable		 5iktB-4s0vA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uf7 GLYCOPROTEIN

(Ghanaian bat
henipavirus) 		PF00423
(HN) 		3 TYR A 464
TYR A 409
SER A 469
 None
 0.97A 5iktB-4uf7A:
undetectable		 5iktB-4uf7A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ufc GH95

(Bacteroides
ovatus) 		PF14498
(Glyco_hyd_65N_2) 		3 TYR A 113
TYR A  49
SER A 118
 None
 0.77A 5iktB-4ufcA:
undetectable		 5iktB-4ufcA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x1z VP1

(Rabbit
hemorrhagic
disease virus) 		PF00915
(Calici_coat) 		3 TYR A 436
TYR A 567
SER A 541
 None
 0.79A 5iktB-4x1zA:
undetectable		 5iktB-4x1zA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yhc STEROL REGULATORY
ELEMENT-BINDING
PROTEIN
CLEAVAGE-ACTIVATING
PROTEIN

(Schizosaccharomyces
pombe) 		no annotation 3 TYR A 607
TYR A 866
SER A 834
 None
 0.95A 5iktB-4yhcA:
undetectable		 5iktB-4yhcA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z0t OXIDOREDUCTASE,
SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY

(Brucella ovis) 		PF00106
(adh_short) 		3 TYR A 157
TYR A 242
SER A 184
 None
 0.93A 5iktB-4z0tA:
undetectable		 5iktB-4z0tA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ze8 ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN
(AGROCINOPINES A AND
B)

(Agrobacterium
fabrum) 		PF00496
(SBP_bac_5) 		3 TYR A 145
TYR A 375
SER A 419
 None
 0.99A 5iktB-4ze8A:
undetectable		 5iktB-4ze8A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zu4 WXCM-LIKE PROTEIN

(Shewanella
denitrificans) 		PF05523
(FdtA) 		3 TYR A 291
TYR A 260
SER A 283
 4TG  A 401 (-4.5A)
None
None
 0.85A 5iktB-4zu4A:
undetectable		 5iktB-4zu4A:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bql FLUORESCENT PROTEIN
CYOFP

(Escherichia
coli) 		PF01353
(GFP) 		3 TYR A 121
TYR A  83
SER A  87
 NRQ  A  67 ( 4.5A)
None
None
 1.00A 5iktB-5bqlA:
undetectable		 5iktB-5bqlA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d28 GM-CSF/IL-2
INHIBITION FACTOR
GRANULOCYTE-MACROPHA
GE
COLONY-STIMULATING
FACTOR

(Orf virus;
Ovis aries) 		no annotation
PF01109
(GM_CSF) 		3 TYR A 228
TYR A 112
SER B  24
 None
 0.98A 5iktB-5d28A:
undetectable		 5iktB-5d28A:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5djq CBB3-TYPE CYTOCHROME
C OXIDASE SUBUNIT
CCON1

(Pseudomonas
stutzeri) 		PF00115
(COX1) 		3 TYR A 317
TYR A 158
SER A 240
 None
 0.87A 5iktB-5djqA:
undetectable		 5iktB-5djqA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ffj ENDONUCLEASE AND
METHYLASE LLAGI

(Lactococcus
lactis) 		PF00271
(Helicase_C)
PF02384
(N6_Mtase)
PF04851
(ResIII) 		3 TYR A1204
TYR A1437
SER A1410
 None
 0.70A 5iktB-5ffjA:
undetectable		 5iktB-5ffjA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g10 HDAH

(Pseudomonas
aeruginosa) 		PF00850
(Hist_deacetyl) 		3 TYR A 313
TYR A 135
SER A 266
 6DK  A1375 (-4.4A)
None
None
 0.84A 5iktB-5g10A:
undetectable		 5iktB-5g10A:
19.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ikr PROSTAGLANDIN G/H
SYNTHASE 2

(Homo sapiens) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		3 TYR A 355
TYR A 385
SER A 530
 ID8  A 601 (-3.8A)
ID8  A 601 ( 3.5A)
ID8  A 601 (-2.7A)
 0.13A 5iktB-5ikrA:
64.8		 5iktB-5ikrA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jen ANTI-SIGMA-V FACTOR
RSIV

(Bacillus
subtilis) 		PF11738
(DUF3298)
PF13739
(DUF4163) 		3 TYR A 170
TYR A 175
SER A 251
 None
 0.80A 5iktB-5jenA:
undetectable		 5iktB-5jenA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k3h ACYL-COENZYME A
OXIDASE

(Caenorhabditis
elegans) 		PF01756
(ACOX)
PF02770
(Acyl-CoA_dh_M)
PF14749
(Acyl-CoA_ox_N) 		3 TYR A  99
TYR A 352
SER A 307
 None
 0.95A 5iktB-5k3hA:
undetectable		 5iktB-5k3hA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kdj F5/8 TYPE C DOMAIN
PROTEIN

(Clostridium
perfringens) 		no annotation 3 TYR B 691
TYR B 834
SER B 783
 None
 0.89A 5iktB-5kdjB:
undetectable		 5iktB-5kdjB:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kds F5/8 TYPE C DOMAIN
PROTEIN

(Clostridium
perfringens) 		PF13402
(Peptidase_M60) 		3 TYR A 691
TYR A 834
SER A 783
 None
 0.80A 5iktB-5kdsA:
undetectable		 5iktB-5kdsA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5khp NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN

(Homo sapiens) 		PF00061
(Lipocalin) 		3 TYR A 100
TYR A  56
SER A  68
 None
 0.78A 5iktB-5khpA:
undetectable		 5iktB-5khpA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lk4 MSCARLET

(Discosoma sp.) 		PF01353
(GFP) 		3 TYR A 121
TYR A  83
SER A  87
 NRQ  A  67 ( 4.5A)
None
None
 0.99A 5iktB-5lk4A:
undetectable		 5iktB-5lk4A:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5me3 SISTER CHROMATID
COHESION PROTEIN 2

(Eremothecium
gossypii) 		PF12765
(Cohesin_HEAT)
PF12830
(Nipped-B_C) 		3 TYR A 438
TYR A 601
SER A 605
 None
 0.92A 5iktB-5me3A:
0.9		 5iktB-5me3A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mpd 26S PROTEASOME
REGULATORY SUBUNIT
RPN7

(Saccharomyces
cerevisiae) 		PF01399
(PCI)
PF10602
(RPN7) 		3 TYR R 213
TYR R  62
SER R  27
 None
 0.93A 5iktB-5mpdR:
undetectable		 5iktB-5mpdR:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nvm EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E
TYPE 2

(Homo sapiens) 		PF01652
(IF4E) 		3 TYR A  78
TYR A  64
SER A 111
 None
 0.98A 5iktB-5nvmA:
undetectable		 5iktB-5nvmA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1

(Synechocystis
sp. PCC 6803) 		no annotation 3 TYR 1 145
TYR 1 668
SER 1 747
 None
CLA  1 808 (-4.0A)
None
 0.95A 5iktB-5oy01:
undetectable		 5iktB-5oy01:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t9g GLYCOSIDE HYDROLASE

(Bacteroides
uniformis) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		3 TYR A 119
TYR A 403
SER A 134
 None
 0.99A 5iktB-5t9gA:
undetectable		 5iktB-5t9gA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ujc MMACHC-LIKE PROTEIN

(Caenorhabditis
elegans) 		PF16690
(MMACHC) 		3 TYR A 122
TYR A 241
SER A  60
 None
TLA  A 301 (-4.5A)
None
 0.99A 5iktB-5ujcA:
undetectable		 5iktB-5ujcA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wlh LBACAS13A H328A
(C2C2)

(Lachnospiraceae
bacterium
NK4A179) 		no annotation 3 TYR A 928
TYR A 477
SER A 482
 A  B  -6 (-3.4A)
None
None
 0.72A 5iktB-5wlhA:
undetectable		 5iktB-5wlhA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6avy ACYL-PROTEIN
THIOESTERASE 2

(Zea mays) 		no annotation 3 TYR A  19
TYR A 150
SER A 135
 None
 0.99A 5iktB-6avyA:
undetectable		 5iktB-6avyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bwe PUTATIVE FIMBRIAL
ASSOCIATED
SORTASE-LIKE PROTEIN

(Corynebacterium
diphtheriae) 		no annotation 3 TYR A 192
TYR A  97
SER A 144
 None
 0.96A 5iktB-6bweA:
undetectable		 5iktB-6bweA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c6l V-TYPE PROTON ATPASE
SUBUNIT A, VACUOLAR
ISOFORM

(Saccharomyces
cerevisiae) 		no annotation 3 TYR A 733
TYR A 397
SER A 807
 None
 0.92A 5iktB-6c6lA:
undetectable		 5iktB-6c6lA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6em0 2-HYDROXYBIPHENYL-3-
MONOOXYGENASE

(Pseudomonas
nitroreducens) 		no annotation 3 TYR A 356
TYR A 144
SER A 182
 None
 1.00A 5iktB-6em0A:
undetectable		 5iktB-6em0A:
undetectable