SIMILAR PATTERNS OF AMINO ACIDS FOR 5IKT_A_TLFA601_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a4s BETAINE ALDEHYDE
DEHYDROGENASE

(Gadus morhua) 		PF00171
(Aldedh) 		5 VAL A 386
VAL A 305
VAL A 282
GLY A 284
ALA A 285
 None
 1.12A 5iktA-1a4sA:
0.0		 5iktA-1a4sA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b3b PROTEIN (GLUTAMATE
DEHYDROGENASE)

(Thermotoga
maritima) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		5 VAL A  95
LEU A 370
VAL A 345
GLY A 343
ALA A 342
 None
 1.03A 5iktA-1b3bA:
0.0		 5iktA-1b3bA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bvu PROTEIN (GLUTAMATE
DEHYDROGENASE)

(Thermococcus
litoralis) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		5 VAL A  95
LEU A 372
VAL A 347
GLY A 345
ALA A 344
 None
 0.98A 5iktA-1bvuA:
0.0		 5iktA-1bvuA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dle COMPLEMENT FACTOR B

(Homo sapiens) 		PF00089
(Trypsin) 		5 VAL A  47
LEU A 181
VAL A 212
GLY A 211
LEU A 123
 None
 0.96A 5iktA-1dleA:
0.0		 5iktA-1dleA:
19.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ebv PROSTAGLANDIN H2
SYNTHASE

(Ovis aries) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		11 VAL A 116
ARG A 120
VAL A 349
SER A 353
TYR A 355
LEU A 384
TRP A 387
MET A 522
GLY A 526
ALA A 527
LEU A 531
 None
SCL  A 700 (-3.9A)
SCL  A 700 ( 4.6A)
None
SCL  A 700 (-4.3A)
None
None
None
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
OAS  A 530 (-4.1A)
 0.45A 5iktA-1ebvA:
35.0		 5iktA-1ebvA:
63.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1elt ELASTASE

(Salmo salar) 		PF00089
(Trypsin) 		5 VAL A  59
VAL A  52
VAL A 212
GLY A 197
LEU A  33
 None
 0.84A 5iktA-1eltA:
undetectable		 5iktA-1eltA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1euz GLUTAMATE
DEHYDROGENASE

(Thermococcus
profundus) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		5 VAL A  96
LEU A 373
VAL A 348
GLY A 346
ALA A 345
 None
None
SO4  A 601 (-3.8A)
None
None
 1.13A 5iktA-1euzA:
undetectable		 5iktA-1euzA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gtm GLUTAMATE
DEHYDROGENASE

(Pyrococcus
furiosus) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		5 VAL A  95
LEU A 373
VAL A 348
GLY A 346
ALA A 345
 None
 1.03A 5iktA-1gtmA:
0.0		 5iktA-1gtmA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hrd GLUTAMATE
DEHYDROGENASE

([Clostridium]
symbiosum) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		5 VAL A 233
VAL A 241
GLY A 244
ALA A 245
LEU A 249
 None
 0.91A 5iktA-1hrdA:
0.0		 5iktA-1hrdA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ia5 POLYGALACTURONASE

(Aspergillus
aculeatus) 		PF00295
(Glyco_hydro_28) 		5 VAL A  26
SER A  28
LEU A 120
GLY A  78
ALA A  79
 None
 1.13A 5iktA-1ia5A:
undetectable		 5iktA-1ia5A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l1f GLUTAMATE
DEHYDROGENASE 1

(Homo sapiens) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		5 VAL A 121
LEU A 457
VAL A 382
GLY A 380
ALA A 379
 None
 1.07A 5iktA-1l1fA:
undetectable		 5iktA-1l1fA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l7v VITAMIN B12
TRANSPORT
ATP-BINDING PROTEIN
BTUD

(Escherichia
coli) 		PF00005
(ABC_tran) 		5 VAL C 135
VAL C 110
GLY C 112
ALA C 111
LEU C 120
 None
 1.10A 5iktA-1l7vC:
undetectable		 5iktA-1l7vC:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lpf DIHYDROLIPOAMIDE
DEHYDROGENASE

(Pseudomonas
fluorescens) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		6 SER A 354
LEU A 457
VAL A 427
GLY A 430
ALA A 431
LEU A 351
 None
 1.49A 5iktA-1lpfA:
undetectable		 5iktA-1lpfA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m0s RIBOSE-5-PHOSPHATE
ISOMERASE A

(Haemophilus
influenzae) 		PF06026
(Rib_5-P_isom_A) 		5 VAL A 106
SER A  56
VAL A  67
GLY A  48
ALA A  49
 None
 1.12A 5iktA-1m0sA:
undetectable		 5iktA-1m0sA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m2w MANNITOL
DEHYDROGENASE

(Pseudomonas
fluorescens) 		PF01232
(Mannitol_dh)
PF08125
(Mannitol_dh_C) 		5 VAL A 186
VAL A 165
VAL A  63
GLY A  33
LEU A 129
 None
None
None
NAD  A5500 (-3.2A)
None
 1.07A 5iktA-1m2wA:
undetectable		 5iktA-1m2wA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mgt PROTEIN
(O6-METHYLGUANINE-DN
A METHYLTRANSFERASE)

(Thermococcus
kodakarensis) 		PF01035
(DNA_binding_1)
PF09153
(DUF1938) 		5 VAL A 138
LEU A  43
VAL A  18
GLY A  26
LEU A  84
 None
 1.03A 5iktA-1mgtA:
undetectable		 5iktA-1mgtA:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ng6 HYPOTHETICAL PROTEIN
YQEY

(Bacillus
subtilis) 		PF09424
(YqeY) 		5 VAL A 143
VAL A 111
GLY A 112
ALA A 113
LEU A 147
 None
 1.08A 5iktA-1ng6A:
undetectable		 5iktA-1ng6A:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nl3 PREPROTEIN
TRANSLOCASE SECA 1
SUBUNIT

(Mycobacterium
tuberculosis) 		PF01043
(SecA_PP_bind)
PF07516
(SecA_SW)
PF07517
(SecA_DEAD) 		5 VAL A  -7
VAL A  87
GLY A  89
ALA A  91
LEU A  95
 None
 1.04A 5iktA-1nl3A:
undetectable		 5iktA-1nl3A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pc3 PHOSPHATE-BINDING
PROTEIN 1

(Mycobacterium
tuberculosis) 		PF12849
(PBP_like_2) 		6 ARG A 236
LEU A 160
MET A 211
VAL A 212
GLY A 214
ALA A 216
 None
 1.44A 5iktA-1pc3A:
undetectable		 5iktA-1pc3A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rtk COMPLEMENT FACTOR B

(Homo sapiens) 		PF00089
(Trypsin)
PF00092
(VWA) 		5 VAL A 491
LEU A 656
VAL A 691
GLY A 690
LEU A 572
 None
 0.90A 5iktA-1rtkA:
undetectable		 5iktA-1rtkA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c1l RESTRICTION
ENDONUCLEASE

(Bacillus firmus) 		PF13091
(PLDc_2) 		5 VAL A  84
TRP A 153
VAL A  67
ALA A  69
LEU A  71
 None
 1.05A 5iktA-2c1lA:
undetectable		 5iktA-2c1lA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dst HYPOTHETICAL PROTEIN
TTHA1544

(Thermus
thermophilus) 		no annotation 6 LEU A   9
MET A  76
VAL A  75
GLY A  72
ALA A  71
LEU A 100
 None
 1.30A 5iktA-2dstA:
undetectable		 5iktA-2dstA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ejb PROBABLE AROMATIC
ACID DECARBOXYLASE

(Aquifex
aeolicus) 		PF02441
(Flavoprotein) 		5 SER A  75
LEU A 121
VAL A 113
GLY A 111
LEU A 106
 None
 1.12A 5iktA-2ejbA:
undetectable		 5iktA-2ejbA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2elc ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N) 		5 TYR A 238
LEU A  74
GLY A 290
ALA A 289
LEU A 223
 None
 1.06A 5iktA-2elcA:
undetectable		 5iktA-2elcA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2elc ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N) 		6 VAL A 215
TYR A 238
LEU A  74
GLY A 290
ALA A 289
LEU A 285
 None
 0.90A 5iktA-2elcA:
undetectable		 5iktA-2elcA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h4t CARNITINE
O-PALMITOYLTRANSFERA
SE II, MITOCHONDRIAL

(Rattus
norvegicus) 		PF00755
(Carn_acyltransf) 		5 VAL A 360
VAL A 387
SER A 391
VAL A 157
LEU A 358
 None
 1.11A 5iktA-2h4tA:
undetectable		 5iktA-2h4tA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h88 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT

(Gallus gallus) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		6 ARG A 484
SER A 545
LEU A 596
GLY A 538
ALA A 539
LEU A 489
 None
 1.30A 5iktA-2h88A:
undetectable		 5iktA-2h88A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hr3 PROBABLE
TRANSCRIPTIONAL
REGULATOR

(Pseudomonas
aeruginosa) 		PF13463
(HTH_27) 		5 LEU A 104
VAL A  39
GLY A  42
ALA A  43
LEU A  47
 None
 0.94A 5iktA-2hr3A:
undetectable		 5iktA-2hr3A:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iuy GLYCOSYLTRANSFERASE

(Streptomyces
viridochromogenes) 		PF00534
(Glycos_transf_1) 		5 VAL A 267
SER A 269
LEU A 315
VAL A 293
LEU A 286
 None
 1.13A 5iktA-2iuyA:
undetectable		 5iktA-2iuyA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pfe ALKALINE SERINE
PROTEASE

(Thermobifida
fusca) 		PF00089
(Trypsin) 		5 VAL A 212
VAL A  47
VAL A 106
GLY A  89
LEU A 234
 None
 1.12A 5iktA-2pfeA:
undetectable		 5iktA-2pfeA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2po4 VIRION RNA
POLYMERASE

(Escherichia
virus N4) 		no annotation 5 SER A 680
LEU A 816
VAL A 917
GLY A 919
ALA A 918
 None
 1.03A 5iktA-2po4A:
0.7		 5iktA-2po4A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ru4 ARMADILLO REPEAT
PROTEIN, N-TERMINAL
FRAGMENT, YIIM2
ARMADILLO REPEAT
PROTEIN, C-TERMINAL
FRAGMENT, MAII

(synthetic
construct;
synthetic
construct) 		PF00514
(Arm)
PF00514
(Arm)
PF16186
(Arm_3) 		5 SER A 110
VAL B 123
GLY B 127
ALA B 128
LEU B 132
 None
 1.07A 5iktA-2ru4A:
undetectable		 5iktA-2ru4A:
12.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v35 ELASTASE-1

(Sus scrofa) 		PF00089
(Trypsin) 		5 VAL A  59
VAL A  52
VAL A 212
GLY A 197
LEU A  33
 None
 0.78A 5iktA-2v35A:
undetectable		 5iktA-2v35A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w21 GLUTAMATE 5-KINASE

(Escherichia
coli) 		PF00696
(AA_kinase) 		6 VAL A   9
LEU A 187
VAL A 251
GLY A 252
ALA A 234
LEU A 168
 None
 1.45A 5iktA-2w21A:
undetectable		 5iktA-2w21A:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wsk GLYCOGEN DEBRANCHING
ENZYME

(Escherichia
coli) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		5 SER A 421
TRP A 579
GLY A 412
ALA A 413
LEU A 409
 None
 0.84A 5iktA-2wskA:
undetectable		 5iktA-2wskA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yzk OROTATE
PHOSPHORIBOSYLTRANSF
ERASE

(Aeropyrum
pernix) 		PF00156
(Pribosyltran) 		5 VAL A 141
SER A 121
GLY A 148
ALA A 149
LEU A 160
 None
 1.09A 5iktA-2yzkA:
undetectable		 5iktA-2yzkA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zec TRYPTASE BETA 2

(Homo sapiens) 		PF00089
(Trypsin) 		5 VAL A  61
VAL A  54
VAL A 226
GLY A 211
LEU A  33
 None
 0.90A 5iktA-2zecA:
undetectable		 5iktA-2zecA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3buj CALO2

(Micromonospora
echinospora) 		PF00067
(p450) 		5 VAL A 190
LEU A 106
VAL A 142
GLY A 144
LEU A 206
 None
 0.89A 5iktA-3bujA:
1.0		 5iktA-3bujA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dah RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE

(Burkholderia
pseudomallei) 		PF13793
(Pribosyltran_N)
PF14572
(Pribosyl_synth) 		5 VAL A 225
SER A 266
GLY A 258
ALA A 259
LEU A 255
 PO4  A 320 ( 4.4A)
None
None
None
None
 1.11A 5iktA-3dahA:
undetectable		 5iktA-3dahA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3esm UNCHARACTERIZED
PROTEIN

(Nocardia
farcinica) 		PF07987
(DUF1775) 		5 VAL A 126
VAL A  45
GLY A  36
ALA A  37
LEU A 120
 None
 1.08A 5iktA-3esmA:
undetectable		 5iktA-3esmA:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f7o SERINE PROTEASE

(Purpureocillium
lilacinum) 		PF00082
(Peptidase_S8) 		5 VAL A 160
VAL A 144
GLY A 147
ALA A 148
LEU A 158
 None
 1.13A 5iktA-3f7oA:
undetectable		 5iktA-3f7oA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fk5 3-OXOACYL-SYNTHASE
III

(Xanthomonas
oryzae) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		6 VAL A 198
LEU A  11
MET A 190
VAL A 191
GLY A  10
ALA A  76
 None
 1.48A 5iktA-3fk5A:
undetectable		 5iktA-3fk5A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h4i GLYCOSYLTRANSFERASE
GTFA,
GLYCOSYLTRANSFERASE

(Actinoplanes
teichomyceticus;
Amycolatopsis
orientalis) 		PF03033
(Glyco_transf_28)
PF04101
(Glyco_tran_28_C) 		5 VAL A  78
VAL A  57
LEU A  17
GLY A   7
LEU A 101
 None
 1.09A 5iktA-3h4iA:
undetectable		 5iktA-3h4iA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hrd NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT

(Eubacterium
barkeri) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		5 VAL A 247
LEU A 117
VAL A 104
GLY A  40
ALA A  39
 None
 1.13A 5iktA-3hrdA:
undetectable		 5iktA-3hrdA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iic CHEC DOMAIN PROTEIN

(Shewanella
loihica) 		PF13690
(CheX) 		5 MET A  95
VAL A  96
GLY A  98
ALA A 100
LEU A 104
 None
 0.95A 5iktA-3iicA:
undetectable		 5iktA-3iicA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ikf 2-C-METHYL-D-ERYTHRI
TOL
2,4-CYCLODIPHOSPHATE
SYNTHASE

(Burkholderia
pseudomallei) 		PF02542
(YgbB) 		5 VAL A  96
SER A  98
GLY A   6
ALA A  49
LEU A  50
 None
 1.10A 5iktA-3ikfA:
undetectable		 5iktA-3ikfA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jsa HOMOSERINE
DEHYDROGENASE

(Thermoplasma
volcanium) 		PF00742
(Homoserine_dh)
PF03447
(NAD_binding_3) 		5 VAL A 115
VAL A  14
LEU A 288
GLY A 148
ALA A 144
 None
NAD  A 501 (-3.8A)
None
NAD  A 501 ( 4.7A)
NAD  A 501 (-4.9A)
 1.04A 5iktA-3jsaA:
undetectable		 5iktA-3jsaA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k31 ENOYL-(ACYL-CARRIER-
PROTEIN) REDUCTASE

(Anaplasma
phagocytophilum) 		PF13561
(adh_short_C2) 		5 VAL A  92
VAL A 227
GLY A 229
ALA A 231
LEU A 235
 None
 1.04A 5iktA-3k31A:
undetectable		 5iktA-3k31A:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3khn MOTB PROTEIN,
PUTATIVE

(Desulfovibrio
vulgaris) 		PF00691
(OmpA) 		6 VAL A 116
VAL A  49
SER A  51
GLY A  65
ALA A  66
LEU A  70
 None
 0.98A 5iktA-3khnA:
undetectable		 5iktA-3khnA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l2z BIRA BIFUNCTIONAL
PROTEIN

(Mycobacterium
tuberculosis) 		PF02237
(BPL_C)
PF03099
(BPL_LplA_LipB) 		5 VAL A  86
LEU A 126
GLY A 106
ALA A 105
LEU A 194
 None
 0.95A 5iktA-3l2zA:
undetectable		 5iktA-3l2zA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nip 3-GUANIDINOPROPIONAS
E

(Pseudomonas
aeruginosa) 		PF00491
(Arginase) 		5 VAL A 282
MET A 144
VAL A 237
ALA A 280
LEU A 120
 None
 1.12A 5iktA-3nipA:
undetectable		 5iktA-3nipA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nmz APC VARIANT PROTEIN

(Homo sapiens) 		PF00514
(Arm) 		5 VAL A 642
VAL A 609
GLY A 611
ALA A 612
LEU A 616
 None
 1.09A 5iktA-3nmzA:
undetectable		 5iktA-3nmzA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o85 RIBOSOMAL PROTEIN
L7AE

(Giardia
intestinalis) 		PF01248
(Ribosomal_L7Ae) 		5 VAL A  92
LEU A 107
VAL A  23
GLY A  26
ALA A  27
 None
 0.87A 5iktA-3o85A:
undetectable		 5iktA-3o85A:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oth CALG1

(Micromonospora
echinospora) 		PF00201
(UDPGT)
PF03033
(Glyco_transf_28) 		6 VAL A 380
VAL A 115
LEU A  43
VAL A  31
ALA A  21
LEU A  20
 None
 1.46A 5iktA-3othA:
undetectable		 5iktA-3othA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qp9 TYPE I POLYKETIDE
SYNTHASE PIKAII

(Streptomyces
venezuelae) 		PF08659
(KR) 		5 VAL A  62
LEU A 345
GLY A 112
ALA A 113
LEU A  93
 None
 1.12A 5iktA-3qp9A:
undetectable		 5iktA-3qp9A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s52 PUTATIVE
FUMARYLACETOACETATE
HYDROLASE FAMILY
PROTEIN

(Yersinia pestis) 		PF01557
(FAA_hydrolase) 		6 VAL A  19
TYR A   2
LEU A 208
GLY A  97
ALA A  74
LEU A 188
 None
 1.40A 5iktA-3s52A:
undetectable		 5iktA-3s52A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w0l GLUCOKINASE
REGULATORY PROTEIN

(Xenopus laevis) 		no annotation 6 VAL B 359
LEU B  49
VAL B 488
GLY B 491
ALA B 492
LEU B 323
 None
 1.48A 5iktA-3w0lB:
0.0		 5iktA-3w0lB:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zw6 RIBULOSE
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E ACTIVASE 1,
CHLOROPLASTIC

(Nicotiana
tabacum) 		PF00004
(AAA) 		5 VAL A 227
VAL A 195
GLY A 137
ALA A 136
LEU A 175
 None
 1.13A 5iktA-3zw6A:
undetectable		 5iktA-3zw6A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a56 PULLULANASE
SECRETION PROTEIN
PULS

(Klebsiella
oxytoca) 		PF09691
(T2SS_PulS_OutS) 		5 LEU A  96
VAL A  42
GLY A  45
ALA A  46
LEU A  58
 None
 1.06A 5iktA-4a56A:
undetectable		 5iktA-4a56A:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4akk NITRATE REGULATORY
PROTEIN

(Klebsiella
oxytoca) 		PF03861
(ANTAR)
PF08376
(NIT) 		5 ARG A 115
MET A  45
VAL A  75
GLY A  71
ALA A  72
 EDO  A1394 (-4.0A)
None
None
None
None
 1.12A 5iktA-4akkA:
undetectable		 5iktA-4akkA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4av6 K(+)-STIMULATED
PYROPHOSPHATE-ENERGI
ZED SODIUM PUMP

(Thermotoga
maritima) 		PF03030
(H_PPase) 		5 LEU A  15
VAL A 133
GLY A 135
ALA A 137
LEU A 141
 None
 1.08A 5iktA-4av6A:
undetectable		 5iktA-4av6A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4czp EXTRALONG MANGANESE
PEROXIDASE

(Gelatoporia
subvermispora) 		PF00141
(peroxidase)
PF11895
(Peroxidase_ext) 		5 VAL A  28
VAL A 112
GLY A 110
ALA A 109
LEU A  90
 None
 1.09A 5iktA-4czpA:
undetectable		 5iktA-4czpA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4di4 TATP(T) (TP0957)

(Treponema
pallidum) 		PF03480
(DctP) 		5 VAL B 111
VAL B 227
MET B 310
GLY B  92
LEU B 119
 None
 1.07A 5iktA-4di4B:
undetectable		 5iktA-4di4B:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4doe 1,4-BETA-GLUCANASE

(Caldicellulosiruptor
bescii) 		PF00759
(Glyco_hydro_9) 		5 LEU A 346
VAL A 284
GLY A 287
ALA A 288
LEU A 292
 None
 1.04A 5iktA-4doeA:
undetectable		 5iktA-4doeA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dz4 AGMATINASE

(Burkholderia
thailandensis) 		PF00491
(Arginase) 		5 VAL A  47
VAL A  69
SER A  73
LEU A 268
ALA A 305
 None
 1.05A 5iktA-4dz4A:
undetectable		 5iktA-4dz4A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ecl SERINE RACEMASE

(Enterococcus
faecalis) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		5 VAL A  20
LEU A  84
VAL A  37
ALA A  35
LEU A  33
 None
 1.12A 5iktA-4eclA:
undetectable		 5iktA-4eclA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fva 5'-TYROSYL-DNA
PHOSPHODIESTERASE

(Caenorhabditis
elegans) 		PF03372
(Exo_endo_phos) 		5 VAL A 226
VAL A 122
LEU A 272
GLY A 269
LEU A 228
 None
 1.09A 5iktA-4fvaA:
undetectable		 5iktA-4fvaA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gew 5'-TYROSYL-DNA
PHOSPHODIESTERASE

(Caenorhabditis
elegans) 		PF03372
(Exo_endo_phos)
PF14555
(UBA_4) 		5 VAL A 226
VAL A 122
LEU A 272
GLY A 269
LEU A 228
 None
 1.08A 5iktA-4gewA:
undetectable		 5iktA-4gewA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gfi MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN

(Agrobacterium
fabrum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 VAL A  70
LEU A 280
GLY A  44
ALA A  95
LEU A  96
 None
 1.13A 5iktA-4gfiA:
undetectable		 5iktA-4gfiA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hka TRYPTOPHAN
2,3-DIOXYGENASE

(Drosophila
melanogaster) 		PF03301
(Trp_dioxygenase) 		5 VAL A 189
LEU A 199
GLY A 275
ALA A 276
LEU A 295
 None
 1.01A 5iktA-4hkaA:
undetectable		 5iktA-4hkaA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4id9 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE

(Agrobacterium
fabrum) 		PF01370
(Epimerase) 		5 LEU A 252
MET A 232
VAL A 233
GLY A 235
LEU A 240
 None
 1.08A 5iktA-4id9A:
undetectable		 5iktA-4id9A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4imp POLYKETIDE SYNTHASE
EXTENDER MODULES 3-4

(Saccharopolyspora
spinosa) 		PF08659
(KR) 		6 VAL A  73
LEU A 106
TRP A  85
GLY A 241
ALA A 243
LEU A 253
 None
 1.32A 5iktA-4impA:
undetectable		 5iktA-4impA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iws PA0254

(Pseudomonas
aeruginosa) 		PF01977
(UbiD) 		5 VAL A 155
VAL A 243
VAL A 233
GLY A 231
ALA A 230
 None
 0.96A 5iktA-4iwsA:
undetectable		 5iktA-4iwsA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m2g L-ARGININE
BETA-HYDROXYLASE

(Streptomyces
lavendulae) 		PF02668
(TauD) 		5 ARG A 270
VAL A 261
LEU A 243
VAL A 197
ALA A 271
 None
 1.05A 5iktA-4m2gA:
undetectable		 5iktA-4m2gA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mrq PHOSPHOMANNOMUTASE/P
HOSPHOGLUCOMUTASE

(Pseudomonas
aeruginosa) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		5 VAL A 153
TRP A 336
VAL A  89
ALA A  93
LEU A  97
 None
 1.04A 5iktA-4mrqA:
undetectable		 5iktA-4mrqA:
21.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ph9 PROSTAGLANDIN G/H
SYNTHASE 2

(Mus musculus) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		12 VAL A 117
ARG A 121
VAL A 350
SER A 354
TYR A 356
LEU A 385
TRP A 388
MET A 523
VAL A 524
GLY A 527
ALA A 528
LEU A 532
 BOG  A 604 (-3.9A)
BOG  A 604 ( 3.7A)
IBP  A 601 (-4.3A)
None
IBP  A 601 (-4.5A)
None
None
None
IBP  A 601 ( 4.0A)
IBP  A 601 (-3.9A)
IBP  A 601 (-3.4A)
IBP  A 601 ( 4.9A)
 0.49A 5iktA-4ph9A:
63.1		 5iktA-4ph9A:
88.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4phz PARTICULATE METHANE
MONOOXYGENASE
SUBUNIT C

(Methylocystis
sp. ATCC 49242) 		no annotation 5 VAL K 234
LEU K  80
GLY K 163
ALA K 164
LEU K 111
 None
PGT  K 302 (-4.6A)
PGT  K 302 (-3.7A)
None
None
 1.13A 5iktA-4phzK:
0.8		 5iktA-4phzK:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ru5 TAILSPIKE GP27

(Pseudomonas
phage phi297) 		no annotation 5 VAL A 389
VAL A 400
VAL A 437
GLY A 414
LEU A 387
 None
 1.08A 5iktA-4ru5A:
undetectable		 5iktA-4ru5A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xf7 CARBOHYDRATE/PYRIMID
INE KINASE, PFKB
FAMILY

(Thermococcus
kodakarensis) 		no annotation 5 VAL A 261
LEU A 108
VAL A 220
GLY A 223
ALA A 224
 None
 1.10A 5iktA-4xf7A:
undetectable		 5iktA-4xf7A:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xij SHIKIMATE
5-DEHYDROGENASE

(Mycolicibacterium
fortuitum) 		PF08501
(Shikimate_dh_N) 		5 VAL A 190
VAL A 142
GLY A 118
ALA A 117
LEU A 114
 None
 1.13A 5iktA-4xijA:
undetectable		 5iktA-4xijA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yk6 ADENOMATOUS
POLYPOSIS COLI
PROTEIN

(Homo sapiens) 		PF00514
(Arm)
PF16629
(Arm_APC_u3) 		5 VAL A 642
VAL A 609
GLY A 611
ALA A 612
LEU A 616
 None
 1.01A 5iktA-4yk6A:
0.2		 5iktA-4yk6A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zqb NADP-DEPENDENT
DEHYDROGENASE

(Rhodobacter
sphaeroides) 		PF02826
(2-Hacid_dh_C) 		5 VAL A 176
LEU A 198
GLY A 149
ALA A 150
LEU A 154
 None
 1.01A 5iktA-4zqbA:
undetectable		 5iktA-4zqbA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ztu DNA POLYMERASE
SUBUNIT GAMMA-2,
MITOCHONDRIAL

(Homo sapiens) 		PF03129
(HGTP_anticodon) 		5 VAL B 104
ARG B 107
LEU B 185
VAL B 213
GLY B 212
 None
 1.13A 5iktA-4ztuB:
undetectable		 5iktA-4ztuB:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cee NAD-DEPENDENT MALIC
ENZYME

(Aster yellows
witches'-broom
phytoplasma) 		PF00390
(malic)
PF03949
(Malic_M) 		5 VAL A 266
VAL A 188
VAL A 260
GLY A 191
LEU A 247
 None
None
NAD  A 401 (-3.5A)
NAD  A 401 (-3.0A)
None
 1.12A 5iktA-5ceeA:
undetectable		 5iktA-5ceeA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gnw BLR0248 PROTEIN

(Bradyrhizobium
diazoefficiens) 		no annotation 5 VAL C 100
TYR C  27
LEU C  69
GLY C  55
LEU C 141
 None
None
URA  C 301 (-3.9A)
URA  C 301 ( 3.9A)
None
 1.04A 5iktA-5gnwC:
undetectable		 5iktA-5gnwC:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikl GERANYL-COA
CARBOXYLASE,
BETA-SUBUNIT

(Pseudomonas
aeruginosa) 		PF01039
(Carboxyl_trans) 		5 VAL B 444
VAL B 453
GLY B 451
ALA B 450
LEU B 485
 None
 0.99A 5iktA-5iklB:
undetectable		 5iktA-5iklB:
22.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ikr PROSTAGLANDIN G/H
SYNTHASE 2

(Homo sapiens) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		12 VAL A 116
ARG A 120
VAL A 349
SER A 353
TYR A 355
LEU A 384
TRP A 387
MET A 522
VAL A 523
GLY A 526
ALA A 527
LEU A 531
 None
ID8  A 601 ( 4.4A)
ID8  A 601 (-3.9A)
ID8  A 601 ( 4.7A)
ID8  A 601 (-3.8A)
ID8  A 601 ( 4.8A)
COH  A 602 (-4.5A)
ID8  A 601 (-4.2A)
ID8  A 601 (-3.6A)
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
 0.32A 5iktA-5ikrA:
64.6		 5iktA-5ikrA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ipx ORF49 PROTEIN

(Human
gammaherpesvirus
8) 		PF04793
(Herpes_BBRF1) 		5 VAL A 163
VAL A 153
GLY A 154
ALA A 155
LEU A 159
 None
 1.10A 5iktA-5ipxA:
undetectable		 5iktA-5ipxA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iva LPS-ASSEMBLY PROTEIN
LPTD

(Pseudomonas
aeruginosa) 		PF04453
(OstA_C) 		5 SER A 408
LEU A 384
VAL A 406
GLY A 424
ALA A 423
 None
 1.06A 5iktA-5ivaA:
undetectable		 5iktA-5ivaA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jfm ALDEHYDE
DEHYDROGENASE

(Rhodopseudomonas
palustris) 		PF00171
(Aldedh) 		5 ARG A 124
LEU A 244
VAL A 120
GLY A 122
LEU A 128
 None
 1.12A 5iktA-5jfmA:
undetectable		 5iktA-5jfmA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jfm ALDEHYDE
DEHYDROGENASE

(Rhodopseudomonas
palustris) 		PF00171
(Aldedh) 		5 ARG A 124
VAL A 205
VAL A 120
GLY A 122
LEU A 128
 None
 1.01A 5iktA-5jfmA:
undetectable		 5iktA-5jfmA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5khn RND TRANSPORTER

(Burkholderia
multivorans) 		no annotation 5 VAL B 765
VAL B 464
GLY B 467
ALA B 468
LEU B 471
 None
 0.93A 5iktA-5khnB:
undetectable		 5iktA-5khnB:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kte DIVALENT METAL
CATION TRANSPORTER
MNTH

(Deinococcus
radiodurans) 		PF01566
(Nramp) 		5 SER A 328
LEU A 374
GLY A 137
ALA A 138
LEU A 321
 None
 0.95A 5iktA-5kteA:
undetectable		 5iktA-5kteA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lae PEROXISOMAL
N(1)-ACETYL-SPERMINE
/SPERMIDINE
OXIDASE,PEROXISOMAL
N(1)-ACETYL-SPERMINE
/SPERMIDINE OXIDASE

(Mus musculus) 		PF01593
(Amino_oxidase) 		5 VAL A   8
LEU A 479
GLY A  19
ALA A  20
LEU A  24
 None
 0.99A 5iktA-5laeA:
undetectable		 5iktA-5laeA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tr1 CHLORIDE CHANNEL
PROTEIN

(Bos taurus) 		PF00654
(Voltage_CLC) 		5 VAL A 226
LEU A  56
VAL A 174
GLY A 204
ALA A 205
 None
 0.85A 5iktA-5tr1A:
undetectable		 5iktA-5tr1A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xmj FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT

(Desulfovibrio
gigas) 		no annotation 5 SER A 545
LEU A 579
GLY A 538
ALA A 539
LEU A 489
 None
 1.12A 5iktA-5xmjA:
undetectable		 5iktA-5xmjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ysm CYTOCHROME P450

(Amycolatopsis
mediterranei) 		no annotation 5 VAL A 390
LEU A 300
MET A 264
GLY A 268
LEU A 279
 None
None
HEM  A 501 (-4.8A)
None
None
 1.08A 5iktA-5ysmA:
undetectable		 5iktA-5ysmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z96 SHORT TRANSIENT
RECEPTOR POTENTIAL
CHANNEL 4

(Mus musculus) 		no annotation 5 LEU A  83
VAL A 109
GLY A 110
ALA A 111
LEU A 100
 None
 1.06A 5iktA-5z96A:
1.7		 5iktA-5z96A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zvt C-TERMINUS OF OUTER
CAPSID PROTEIN VP5

(Aquareovirus C) 		no annotation 5 VAL B 353
SER B 369
GLY B 401
ALA B 400
LEU B 422
 None
 1.07A 5iktA-5zvtB:
undetectable		 5iktA-5zvtB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ch3 FLAGELLAR SECRETION
CHAPERONE
FLIS,FLAGELLIN

(Salmonella
enterica) 		no annotation 5 VAL B 111
LEU B 197
GLY B  34
ALA B  35
LEU B  39
 None
 1.10A 5iktA-6ch3B:
undetectable		 5iktA-6ch3B:
undetectable