SIMILAR PATTERNS OF AMINO ACIDS FOR 5IKR_B_ID8B602_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1adr P22 C2 REPRESSOR

(Salmonella
virus P22) 		PF01381
(HTH_3) 		3 SER A  36
LEU A  64
MET A   6
 None
 0.76A 5ikrB-1adrA:
undetectable		 5ikrB-1adrA:
8.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1avm SUPEROXIDE DISMUTASE

(Propionibacterium
freudenreichii) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		3 SER A  76
LEU A  15
MET A  82
 None
 0.82A 5ikrB-1avmA:
0.0		 5ikrB-1avmA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bev BOVINE ENTEROVIRUS
COAT PROTEINS VP1 TO
VP4

(Enterovirus E) 		PF00073
(Rhv) 		3 SER 1 244
LEU 1 105
MET 1 109
 None
None
MYR  1 900 ( 4.9A)
 0.87A 5ikrB-1bev1:
undetectable		 5ikrB-1bev1:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cjy PROTEIN (CYTOSOLIC
PHOSPHOLIPASE A2)

(Homo sapiens) 		PF00168
(C2)
PF01735
(PLA2_B) 		3 SER A 230
LEU A 386
MET A 390
 None
 0.78A 5ikrB-1cjyA:
0.0		 5ikrB-1cjyA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1deu PROCATHEPSIN X

(Homo sapiens) 		PF00112
(Peptidase_C1) 		3 SER A 136
LEU A   1
MET A 142
 None
 0.87A 5ikrB-1deuA:
0.0		 5ikrB-1deuA:
17.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ebv PROSTAGLANDIN H2
SYNTHASE

(Ovis aries) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		3 SER A 353
LEU A 384
MET A 522
 None
 0.35A 5ikrB-1ebvA:
58.5		 5ikrB-1ebvA:
63.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fbw ENDO-1,4-BETA-GLUCAN
ASE F

([Clostridium]
cellulolyticum) 		PF02011
(Glyco_hydro_48) 		3 SER A  37
LEU A  88
MET A  57
 None
 0.83A 5ikrB-1fbwA:
0.0		 5ikrB-1fbwA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h71 SERRALYSIN

(Pseudomonas sp.
'TAC II 18') 		PF00413
(Peptidase_M10)
PF08548
(Peptidase_M10_C) 		3 SER P 229
LEU P 177
MET P 207
 None
 0.87A 5ikrB-1h71P:
0.0		 5ikrB-1h71P:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ikf IGG1-KAPPA R45-45-11
FAB (HEAVY CHAIN)

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER H  88
LEU H  81
MET H  83
 None
 0.88A 5ikrB-1ikfH:
undetectable		 5ikrB-1ikfH:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j32 ASPARTATE
AMINOTRANSFERASE

(Phormidium
lapideum) 		PF00155
(Aminotran_1_2) 		3 SER A  36
LEU A 307
MET A 324
 None
 0.84A 5ikrB-1j32A:
0.0		 5ikrB-1j32A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1php 3-PHOSPHOGLYCERATE
KINASE

(Geobacillus
stearothermophilus) 		PF00162
(PGK) 		3 SER A 370
LEU A 338
MET A 366
 None
 0.76A 5ikrB-1phpA:
undetectable		 5ikrB-1phpA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1poy SPERMIDINE/PUTRESCIN
E-BINDING PROTEIN

(Escherichia
coli) 		PF13416
(SBP_bac_8) 		3 SER 1 150
LEU 1 165
MET 1 227
 None
 0.72A 5ikrB-1poy1:
undetectable		 5ikrB-1poy1:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rh9 ENDO-BETA-MANNANASE

(Solanum
lycopersicum) 		PF00150
(Cellulase) 		3 SER A  91
LEU A 127
MET A 129
 None
 0.85A 5ikrB-1rh9A:
undetectable		 5ikrB-1rh9A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sde D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE

(Streptomyces
sp. R61) 		PF00144
(Beta-lactamase) 		3 SER A  86
LEU A 282
MET A 106
 None
 0.61A 5ikrB-1sdeA:
undetectable		 5ikrB-1sdeA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uhg OVALBUMIN

(Gallus gallus) 		PF00079
(Serpin) 		3 SER A 307
LEU A 105
MET A 172
 None
 0.72A 5ikrB-1uhgA:
undetectable		 5ikrB-1uhgA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1up2 CELA1 PROTEIN

(Mycobacterium
tuberculosis) 		PF01341
(Glyco_hydro_6) 		3 SER A 292
LEU A 208
MET A 256
 None
 0.77A 5ikrB-1up2A:
undetectable		 5ikrB-1up2A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vgp 373AA LONG
HYPOTHETICAL CITRATE
SYNTHASE

(Sulfurisphaera
tokodaii) 		PF00285
(Citrate_synt) 		3 SER A 314
LEU A 154
MET A 170
 None
 0.88A 5ikrB-1vgpA:
undetectable		 5ikrB-1vgpA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xre SUPEROXIDE DISMUTASE

(Bacillus
anthracis) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		3 SER A  84
LEU A  16
MET A  90
 None
 0.82A 5ikrB-1xreA:
undetectable		 5ikrB-1xreA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xss FLUORESCENT PROTEIN

(Favia favus) 		PF01353
(GFP) 		3 SER A 220
LEU A 156
MET A 149
 None
 0.80A 5ikrB-1xssA:
undetectable		 5ikrB-1xssA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xv5 DNA
ALPHA-GLUCOSYLTRANSF
ERASE

(Escherichia
virus T4) 		PF11440
(AGT) 		3 SER A1020
LEU A1310
MET A1178
 None
 0.81A 5ikrB-1xv5A:
undetectable		 5ikrB-1xv5A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zvy IMMUNOGLOBULIN HEAVY
CHAIN ANTIBODY
VARIABLE DOMAIN

(Camelus
dromedarius) 		PF07686
(V-set) 		3 SER A  88
LEU A  81
MET A  83
 None
 0.86A 5ikrB-1zvyA:
undetectable		 5ikrB-1zvyA:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bre ATP-DEPENDENT
MOLECULAR CHAPERONE
HSP82

(Saccharomyces
cerevisiae) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		3 SER A  80
LEU A  89
MET A  84
 None
None
KJ2  A1214 (-4.0A)
 0.85A 5ikrB-2breA:
undetectable		 5ikrB-2breA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dgd 223AA LONG
HYPOTHETICAL
ARYLMALONATE
DECARBOXYLASE

(Sulfurisphaera
tokodaii) 		no annotation 3 SER A  32
LEU A 220
MET A  26
 None
 0.76A 5ikrB-2dgdA:
undetectable		 5ikrB-2dgdA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ec5 DERMONECROTIC TOXIN

(Pasteurella
multocida) 		PF11647
(MLD) 		3 SER A 874
LEU A1016
MET A1056
 None
 0.62A 5ikrB-2ec5A:
undetectable		 5ikrB-2ec5A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i9x PUTATIVE SEPTATION
PROTEIN SPOVG

(Staphylococcus
epidermidis) 		PF04026
(SpoVG) 		3 SER A  66
LEU A  25
MET A   1
 None
 0.86A 5ikrB-2i9xA:
undetectable		 5ikrB-2i9xA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i9z PUTATIVE SEPTATION
PROTEIN SPOVG

(Staphylococcus
epidermidis) 		PF04026
(SpoVG) 		3 SER A  66
LEU A  25
MET A   1
 None
 0.87A 5ikrB-2i9zA:
undetectable		 5ikrB-2i9zA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2idl HYPOTHETICAL PROTEIN

(Streptococcus
pneumoniae) 		PF04327
(Peptidase_Prp) 		3 SER A 103
LEU A  40
MET A  95
 None
 0.75A 5ikrB-2idlA:
undetectable		 5ikrB-2idlA:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iv2 FORMATE
DEHYDROGENASE H

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		3 SER X 445
LEU X  75
MET X  66
 2MD  X 801 (-2.9A)
None
None
 0.70A 5ikrB-2iv2X:
undetectable		 5ikrB-2iv2X:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jjx URIDYLATE KINASE

(Bacillus
anthracis) 		PF00696
(AA_kinase) 		3 SER A 145
LEU A 122
MET A 152
 None
 0.81A 5ikrB-2jjxA:
undetectable		 5ikrB-2jjxA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jv9 SMOOTHELIN-LIKE 1

(Mus musculus) 		PF00307
(CH) 		3 SER A  30
LEU A  81
MET A  86
 None
 0.87A 5ikrB-2jv9A:
undetectable		 5ikrB-2jv9A:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q09 IMIDAZOLONEPROPIONAS
E

(unidentified) 		PF01979
(Amidohydro_1) 		3 SER A 315
LEU A 305
MET A 312
 None
 0.76A 5ikrB-2q09A:
undetectable		 5ikrB-2q09A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r5k MAJOR CAPSID PROTEIN
L1

(Alphapapillomavirus
10) 		PF00500
(Late_protein_L1) 		3 SER A 393
LEU A 379
MET A 384
 None
 0.82A 5ikrB-2r5kA:
undetectable		 5ikrB-2r5kA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yky BETA-TRANSAMINASE

(Mesorhizobium
sp. LUK) 		PF00202
(Aminotran_3) 		3 SER A 383
LEU A 368
MET A 222
 None
SFE  A1447 (-4.9A)
None
 0.58A 5ikrB-2ykyA:
undetectable		 5ikrB-2ykyA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aag GENERAL
GLYCOSYLATION
PATHWAY PROTEIN

(Campylobacter
jejuni) 		PF02516
(STT3) 		3 SER A 536
LEU A 504
MET A 529
 None
 0.60A 5ikrB-3aagA:
undetectable		 5ikrB-3aagA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ce2 PUTATIVE PEPTIDASE

(Chlamydia
abortus) 		PF01432
(Peptidase_M3)
PF08439
(Peptidase_M3_N) 		3 SER A 375
LEU A 350
MET A 406
 None
 0.78A 5ikrB-3ce2A:
1.6		 5ikrB-3ce2A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cky 2-HYDROXYMETHYL
GLUTARATE
DEHYDROGENASE

(Eubacterium
barkeri) 		PF03446
(NAD_binding_2)
PF14833
(NAD_binding_11) 		3 SER A 213
LEU A 200
MET A 205
 None
 0.87A 5ikrB-3ckyA:
undetectable		 5ikrB-3ckyA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dzu RETINOIC ACID
RECEPTOR RXR-ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		3 SER A 355
LEU A 367
MET A 362
 None
 0.80A 5ikrB-3dzuA:
0.9		 5ikrB-3dzuA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e0s UNCHARACTERIZED
PROTEIN

(Chlorobaculum
tepidum) 		PF05235
(CHAD) 		3 SER A 264
LEU A 354
MET A 281
 None
 0.75A 5ikrB-3e0sA:
0.4		 5ikrB-3e0sA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3evk SUPEROXIDE DISMUTASE
[FE]

(Pyrobaculum
aerophilum) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		3 SER A  91
LEU A  30
MET A  97
 None
 0.76A 5ikrB-3evkA:
undetectable		 5ikrB-3evkA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f70 LETHAL(3)MALIGNANT
BRAIN TUMOR-LIKE 2
PROTEIN

(Homo sapiens) 		PF02820
(MBT) 		3 SER A 335
LEU A 442
MET A 548
 None
 0.86A 5ikrB-3f70A:
undetectable		 5ikrB-3f70A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h1l MITOCHONDRIAL
UBIQUINOL-CYTOCHROME
-C REDUCTASE COMPLEX
CORE PROTEIN 2

(Gallus gallus) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		3 SER B 310
LEU B 439
MET B 341
 None
 0.59A 5ikrB-3h1lB:
undetectable		 5ikrB-3h1lB:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3icq EXPORTIN-T

(Schizosaccharomyces
pombe) 		PF08389
(Xpo1) 		3 SER T 825
LEU T 862
MET T 866
 None
 0.77A 5ikrB-3icqT:
1.6		 5ikrB-3icqT:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3in5 DNA POLYMERASE KAPPA

(Homo sapiens) 		PF00817
(IMS)
PF11798
(IMS_HHH)
PF11799
(IMS_C) 		3 SER A 423
LEU A 438
MET A 509
 None
 0.84A 5ikrB-3in5A:
undetectable		 5ikrB-3in5A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j9f POLIOVIRUS RECEPTOR

(Homo sapiens) 		PF07686
(V-set) 		3 SER 7 107
LEU 7 113
MET 7 110
 NAG  7 401 ( 3.7A)
None
None
 0.84A 5ikrB-3j9f7:
undetectable		 5ikrB-3j9f7:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb4 VP1

(Parechovirus B) 		no annotation 3 SER A 165
LEU A 179
MET A 169
 None
 0.85A 5ikrB-3jb4A:
undetectable		 5ikrB-3jb4A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jru PROBABLE CYTOSOL
AMINOPEPTIDASE

(Xanthomonas
oryzae) 		no annotation 3 SER B 332
LEU B 243
MET B 222
 None
 0.83A 5ikrB-3jruB:
undetectable		 5ikrB-3jruB:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3juu PORPHYRANASE B

(Zobellia
galactanivorans) 		PF00722
(Glyco_hydro_16) 		3 SER A 136
LEU A 231
MET A 180
 None
 0.71A 5ikrB-3juuA:
undetectable		 5ikrB-3juuA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k60 HEAT SHOCK PROTEIN
86

(Plasmodium
falciparum) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		3 SER A  80
LEU A  89
MET A  84
 None
None
ADP  A 400 (-3.6A)
 0.87A 5ikrB-3k60A:
undetectable		 5ikrB-3k60A:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kky SUPEROXIDE DISMUTASE
[MN]

(Deinococcus
radiodurans) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		3 SER A  81
LEU A  14
MET A  87
 None
 0.80A 5ikrB-3kkyA:
undetectable		 5ikrB-3kkyA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kx2 PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43

(Saccharomyces
cerevisiae) 		no annotation 3 SER B 247
LEU B 105
MET B 112
 None
 0.83A 5ikrB-3kx2B:
undetectable		 5ikrB-3kx2B:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3led 3-OXOACYL-ACYL
CARRIER PROTEIN
SYNTHASE III

(Rhodopseudomonas
palustris) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		3 SER A 356
LEU A 290
MET A 293
 None
 0.66A 5ikrB-3ledA:
undetectable		 5ikrB-3ledA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm8 THIAMINE
PYROPHOSPHOKINASE

(Bacillus
subtilis) 		PF04263
(TPK_catalytic)
PF04265
(TPK_B1_binding) 		3 SER A 156
LEU A 117
MET A 138
 None
 0.84A 5ikrB-3lm8A:
undetectable		 5ikrB-3lm8A:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nlc UNCHARACTERIZED
PROTEIN VP0956

(Vibrio
parahaemolyticus) 		no annotation 3 SER A 249
LEU A 274
MET A 273
 None
 0.86A 5ikrB-3nlcA:
undetectable		 5ikrB-3nlcA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nxh TRANSCRIPTIONAL
REGULATOR YVHJ

(Bacillus
subtilis) 		PF03816
(LytR_cpsA_psr) 		3 SER A 140
LEU A  80
MET A  82
 None
 0.85A 5ikrB-3nxhA:
undetectable		 5ikrB-3nxhA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p52 NH(3)-DEPENDENT
NAD(+) SYNTHETASE

(Campylobacter
jejuni) 		PF02540
(NAD_synthase) 		3 SER A  87
LEU A  54
MET A  56
 None
None
NO3  A 247 (-4.6A)
 0.76A 5ikrB-3p52A:
undetectable		 5ikrB-3p52A:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pic CIP2

(Trichoderma
reesei) 		no annotation 3 SER A 278
LEU A 357
MET A 285
 None
 0.85A 5ikrB-3picA:
undetectable		 5ikrB-3picA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rp7 FLAVOPROTEIN
MONOOXYGENASE

(Klebsiella
pneumoniae) 		PF01494
(FAD_binding_3) 		3 SER A 146
LEU A  -5
MET A   1
 None
 0.62A 5ikrB-3rp7A:
undetectable		 5ikrB-3rp7A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ru8 EPITOPE SCAFFOLD
2BODX43

(Human
immunodeficiency
virus;
Thermobifida
fusca;
synthetic
construct) 		PF01341
(Glyco_hydro_6) 		3 SER X 148
LEU X 160
MET X 156
 None
None
GOL  X 283 (-4.4A)
 0.77A 5ikrB-3ru8X:
undetectable		 5ikrB-3ru8X:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3smt HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3

(Homo sapiens) 		PF00856
(SET)
PF09273
(Rubis-subs-bind) 		3 SER A 345
LEU A 394
MET A 351
 None
None
UNX  A 509 ( 4.4A)
 0.88A 5ikrB-3smtA:
undetectable		 5ikrB-3smtA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uwd PHOSPHOGLYCERATE
KINASE

(Bacillus
anthracis) 		PF00162
(PGK) 		3 SER A 370
LEU A 338
MET A 366
 None
 0.85A 5ikrB-3uwdA:
undetectable		 5ikrB-3uwdA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bvu PROTEIN KINASE OSPG

(Shigella
flexneri) 		no annotation 3 SER A 152
LEU A 139
MET A 144
 None
 0.72A 5ikrB-4bvuA:
undetectable		 5ikrB-4bvuA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hf5 FAB 8F8 HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER H  21
LEU H  82
MET H  82
 None
 0.86A 5ikrB-4hf5H:
undetectable		 5ikrB-4hf5H:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4js1 BETA-GALACTOSIDE
ALPHA-2,6-SIALYLTRAN
SFERASE 1

(Homo sapiens) 		PF00777
(Glyco_transf_29) 		3 SER A 151
LEU A 209
MET A 331
 None
 0.72A 5ikrB-4js1A:
undetectable		 5ikrB-4js1A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jxu PUTATIVE
AMINOTRANSFERASE

(Sinorhizobium
meliloti) 		PF01063
(Aminotran_4) 		3 SER A 238
LEU A 141
MET A 241
 None
 0.79A 5ikrB-4jxuA:
undetectable		 5ikrB-4jxuA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nxr T-LYMPHOMA INVASION
AND
METASTASIS-INDUCING
PROTEIN 1

(Homo sapiens) 		PF00595
(PDZ) 		3 SER A 919
LEU A 906
MET A 911
 None
 0.77A 5ikrB-4nxrA:
undetectable		 5ikrB-4nxrA:
12.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ph9 PROSTAGLANDIN G/H
SYNTHASE 2

(Mus musculus) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		3 SER A 354
LEU A 385
MET A 523
 None
 0.15A 5ikrB-4ph9A:
62.8		 5ikrB-4ph9A:
88.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uok FAB FRAGMENT HEAVY
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER A 317
LEU A 263
MET A 255
 None
 0.70A 5ikrB-4uokA:
undetectable		 5ikrB-4uokA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w6w NBFEDF6

(Lama glama) 		PF07686
(V-set) 		3 SER B 854
LEU B 878
MET B 834
 None
 0.86A 5ikrB-4w6wB:
undetectable		 5ikrB-4w6wB:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xeb GLUCANASE

(Talaromyces
funiculosus) 		PF00840
(Glyco_hydro_7) 		3 SER A 331
LEU A 210
MET A 356
 None
 0.80A 5ikrB-4xebA:
undetectable		 5ikrB-4xebA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y0i 4-AMINOBUTYRATE
AMINOTRANSFERASE,
MITOCHONDRIAL

(Sus scrofa) 		PF00202
(Aminotran_3) 		3 SER A  73
LEU A 364
MET A 332
 None
 0.86A 5ikrB-4y0iA:
undetectable		 5ikrB-4y0iA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a35 GLYCINE CLEAVAGE
SYSTEM H PROTEIN

(Streptococcus
pyogenes) 		PF01597
(GCV_H) 		3 SER A  63
LEU A  83
MET A  21
 None
 0.76A 5ikrB-5a35A:
undetectable		 5ikrB-5a35A:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a89 RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBF

(Corynebacterium
ammoniagenes) 		PF01687
(Flavokinase) 		3 SER A 269
LEU A 303
MET A 307
 None
FMN  A 339 (-4.9A)
FMN  A 339 (-4.3A)
 0.85A 5ikrB-5a89A:
undetectable		 5ikrB-5a89A:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ahk ACETOLACTATE
SYNTHASE II, LARGE
SUBUNIT

(Pseudomonas
protegens) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		3 SER A 416
LEU A 405
MET A 413
 None
 0.79A 5ikrB-5ahkA:
undetectable		 5ikrB-5ahkA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cs0 ACETYL-COA
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF08326
(ACC_central) 		3 SER A 848
LEU A 881
MET A 862
 None
 0.84A 5ikrB-5cs0A:
undetectable		 5ikrB-5cs0A:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5csl ACETYL-COA
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF01039
(Carboxyl_trans)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2)
PF08326
(ACC_central) 		3 SER A 848
LEU A 881
MET A 862
 None
 0.85A 5ikrB-5cslA:
undetectable		 5ikrB-5cslA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5da0 NANOBODY

(Lama glama) 		PF07686
(V-set) 		3 SER B  24
LEU B  89
MET B  86
 None
 0.84A 5ikrB-5da0B:
undetectable		 5ikrB-5da0B:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dny DNA DOUBLE-STRAND
BREAK REPAIR PROTEIN
MRE11

(Methanocaldococcus
jannaschii) 		PF00149
(Metallophos) 		3 SER A 180
LEU A 107
MET A 156
 None
 0.75A 5ikrB-5dnyA:
undetectable		 5ikrB-5dnyA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e02 FRQ-INTERACTING RNA
HELICASE

(Neurospora
crassa) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF08148
(DSHCT)
PF13234
(rRNA_proc-arch) 		3 SER A 264
LEU A 273
MET A 268
 None
 0.85A 5ikrB-5e02A:
undetectable		 5ikrB-5e02A:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ehk LANTIBIOTIC
DEHYDRATASE

(Microbispora
corallina) 		PF04738
(Lant_dehydr_N)
PF14028
(Lant_dehydr_C) 		3 SER A 231
LEU A 272
MET A 276
 None
 0.80A 5ikrB-5ehkA:
undetectable		 5ikrB-5ehkA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eks 3-DEHYDROQUINATE
SYNTHASE

(Acinetobacter
baumannii) 		PF01761
(DHQ_synthase) 		3 SER A 304
LEU A 189
MET A 271
 None
 0.82A 5ikrB-5eksA:
undetectable		 5ikrB-5eksA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f9w HEAVY CHAIN OF
CH235-LINEAGE
ANTIBODY CH235

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER B  21
LEU B  82
MET B  82
 None
 0.83A 5ikrB-5f9wB:
undetectable		 5ikrB-5f9wB:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gxu NADPH--CYTOCHROME
P450 REDUCTASE 2

(Arabidopsis
thaliana) 		PF00175
(NAD_binding_1)
PF00258
(Flavodoxin_1)
PF00667
(FAD_binding_1) 		3 SER A 416
LEU A 369
MET A 465
 FAD  A 802 (-3.1A)
None
None
 0.83A 5ikrB-5gxuA:
undetectable		 5ikrB-5gxuA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hsb RNA POLYMERASE

(Andes
orthohantavirus) 		no annotation 3 SER A  90
LEU A 138
MET A  74
 None
 0.67A 5ikrB-5hsbA:
undetectable		 5ikrB-5hsbA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ltq GREEN FLUORESCENT
PROTEIN BLFP-Y3

(Branchiostoma
lanceolatum) 		PF01353
(GFP) 		3 SER A  14
LEU A  39
MET A  22
 None
 0.82A 5ikrB-5ltqA:
undetectable		 5ikrB-5ltqA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m38 OMPA FAMILY PROTEIN

(Escherichia
coli) 		no annotation 3 SER A  80
LEU A  30
MET A  71
 None
 0.79A 5ikrB-5m38A:
undetectable		 5ikrB-5m38A:
9.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mrw POTASSIUM-TRANSPORTI
NG ATPASE
POTASSIUM-BINDING
SUBUNIT

(Escherichia
coli) 		PF03814
(KdpA) 		3 SER A 378
LEU A  63
MET A 501
 None
 0.72A 5ikrB-5mrwA:
1.5		 5ikrB-5mrwA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mwc GENETICALLY-ENCODED
GREEN CALCIUM
INDICATOR NTNC

(synthetic
construct) 		no annotation 3 SER D  24
LEU D  49
MET D  32
 None
 0.83A 5ikrB-5mwcD:
undetectable		 5ikrB-5mwcD:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nqa POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 4

(Homo sapiens) 		no annotation 3 SER A 473
LEU A 502
MET A 515
 None
 0.86A 5ikrB-5nqaA:
undetectable		 5ikrB-5nqaA:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nv6 TRANSFORMING GROWTH
FACTOR-BETA-INDUCED
PROTEIN IG-H3

(Homo sapiens) 		PF02469
(Fasciclin) 		3 SER A 516
LEU A 531
MET A 506
 None
 0.81A 5ikrB-5nv6A:
undetectable		 5ikrB-5nv6A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ogl UNDECAPRENYL-DIPHOSP
HOOLIGOSACCHARIDE--P
ROTEIN
GLYCOTRANSFERASE

(Campylobacter
lari) 		no annotation 3 SER A 538
LEU A 510
MET A 530
 None
 0.85A 5ikrB-5oglA:
undetectable		 5ikrB-5oglA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2

(Synechocystis
sp. PCC 6803) 		no annotation 3 SER b   9
LEU b  42
MET b  37
 None
 0.77A 5ikrB-5oy0b:
undetectable		 5ikrB-5oy0b:
8.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tc1 MATURATION PROTEIN

(Escherichia
virus MS2) 		PF03863
(Phage_mat-A) 		3 SER M 376
LEU M 275
MET M 306
 None
 0.87A 5ikrB-5tc1M:
undetectable		 5ikrB-5tc1M:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v72 NADPH-DEPENDENT
GLYOXYLATE/HYDROXYPY
RUVATE REDUCTASE

(Sinorhizobium
meliloti) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		3 SER A  63
LEU A  53
MET A  58
 None
 0.88A 5ikrB-5v72A:
undetectable		 5ikrB-5v72A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w76 ANCESTRAL ELOGATION
FACTOR N153

(synthetic
construct) 		no annotation 3 SER A  64
LEU A 122
MET A  92
 None
 0.76A 5ikrB-5w76A:
undetectable		 5ikrB-5w76A:
8.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y79 PUTATIVE HEXOSE
PHOSPHATE
TRANSLOCATOR

(Galdieria
sulphuraria) 		PF03151
(TPT) 		3 SER A 193
LEU A 325
MET A 133
 None
 0.87A 5ikrB-5y79A:
undetectable		 5ikrB-5y79A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bfu SPIKE PROTEIN

(Coronavirus
HKU15) 		no annotation 3 SER A 383
LEU A 356
MET A 388
 None
 0.79A 5ikrB-6bfuA:
undetectable		 5ikrB-6bfuA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bq1 PHOSPHATIDYLINOSITOL
4-KINASE III ALPHA
(PI4KA)

(Homo sapiens) 		no annotation 3 SER A1622
LEU A1860
MET A2041
 None
 0.68A 5ikrB-6bq1A:
undetectable		 5ikrB-6bq1A:
0.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bsp U4 HEAVY CHAIN

(Mus musculus) 		no annotation 3 SER A  21
LEU A  82
MET A  82
 None
 0.76A 5ikrB-6bspA:
undetectable		 5ikrB-6bspA:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fnu METHYLENETETRAHYDROF
OLATE REDUCTASE 1

(Saccharomyces
cerevisiae) 		no annotation 3 SER A  16
LEU A  31
MET A  35
 None
 0.77A 5ikrB-6fnuA:
undetectable		 5ikrB-6fnuA:
9.44